Home

Download

Statistics

Examples

Help

Contact

	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:LACTB2-ITPR2 (FusionGDB2 ID:43825)

Fusion Gene Summary for LACTB2-ITPR2

Fusion gene summary

Fusion gene information	Fusion gene name: LACTB2-ITPR2
	Fusion gene ID: 43825
		Hgene	Tgene
	Gene symbol	LACTB2	ITPR2
	Gene ID	51110	3709
	Gene name	lactamase beta 2	inositol 1,4,5-trisphosphate receptor type 2
	Synonyms	CGI-83	ANHD\|CFAP48\|INSP3R2\|IP3R2
	Cytomap	8q13.3	12p11.23
	Type of gene	protein-coding	protein-coding
	Description	endoribonuclease LACTB2beta-lactamase-like protein 2testicular secretory protein Li 23	inositol 1,4,5-trisphosphate receptor type 2IP3 receptorIP3R 2cilia and flagella associated protein 48type 2 InsP3 receptor
	Modification date	20200313	20200313
	UniProtAcc	Q53H82	Q14571
	Ensembl transtripts involved in fusion gene	ENST00000276590, ENST00000517601, ENST00000522447,	ENST00000242737, ENST00000545902, ENST00000381340,
Fusion gene scores	* DoF score	3 X 3 X 3=27	27 X 21 X 12=6804
	# samples	3	27
	** MAII score	log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(27/6804*10)=-4.65535182861255 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: LACTB2 [Title/Abstract] AND ITPR2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	LACTB2(71550783)-ITPR2(26636831), # samples:1
Anticipated loss of major functional domain due to fusion event.	LACTB2-ITPR2 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF. LACTB2-ITPR2 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	LACTB2	GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic	26826708
Tgene	ITPR2	GO:0001666	response to hypoxia	19120137

Fusion gene breakpoints across LACTB2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ITPR2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LUAD	TCGA-91-6828-01A	LACTB2	chr8	71550783	-	ITPR2	chr12	26636831	-

Top

Fusion Gene ORF analysis for LACTB2-ITPR2

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000276590	ENST00000242737	LACTB2	chr8	71550783	-	ITPR2	chr12	26636831	-
5CDS-intron	ENST00000276590	ENST00000545902	LACTB2	chr8	71550783	-	ITPR2	chr12	26636831	-
5CDS-intron	ENST00000517601	ENST00000242737	LACTB2	chr8	71550783	-	ITPR2	chr12	26636831	-
5CDS-intron	ENST00000517601	ENST00000545902	LACTB2	chr8	71550783	-	ITPR2	chr12	26636831	-
5CDS-intron	ENST00000522447	ENST00000242737	LACTB2	chr8	71550783	-	ITPR2	chr12	26636831	-
5CDS-intron	ENST00000522447	ENST00000545902	LACTB2	chr8	71550783	-	ITPR2	chr12	26636831	-
Frame-shift	ENST00000276590	ENST00000381340	LACTB2	chr8	71550783	-	ITPR2	chr12	26636831	-
Frame-shift	ENST00000517601	ENST00000381340	LACTB2	chr8	71550783	-	ITPR2	chr12	26636831	-
In-frame	ENST00000522447	ENST00000381340	LACTB2	chr8	71550783	-	ITPR2	chr12	26636831	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000522447

LACTB2

chr8

71550783

ENST00000381340

ITPR2

chr12

26636831

5160

877

883

3171

762

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000522447	ENST00000381340	LACTB2	chr8	71550783	-	ITPR2	chr12	26636831	-	0.000174654	0.9998254

Top

Fusion Genomic Features for LACTB2-ITPR2

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for LACTB2-ITPR2

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:71550783/chr12:26636831)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
LACTB2 Q53H82	ITPR2 Q14571
FUNCTION: Endoribonuclease; cleaves preferentially 3' to purine-pyrimidine dinucleotide motifs in single-stranded RNA. The cleavage product contains a free 3' -OH group. Has no activity with double-stranded RNA or DNA. Required for normal mitochondrial function and cell viability. {ECO:0000269\|PubMed:26826708}.	FUNCTION: Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. This release is regulated by cAMP both dependently and independently of PKA (By similarity). {ECO:0000250\|UniProtKB:Q9Z329}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

ITPR2

chr8:71550783

chr12:26636831

ENST00000242737

112_166

182.0

Domain

MIR 1

Tgene

ITPR2

chr8:71550783

chr12:26636831

ENST00000242737

173_223

182.0

Domain

MIR 2

Tgene

ITPR2

chr8:71550783

chr12:26636831

ENST00000242737

231_287

182.0

Domain

MIR 3

Tgene

ITPR2

chr8:71550783

chr12:26636831

ENST00000242737

294_372

182.0

Domain

MIR 4

Tgene

ITPR2

chr8:71550783

chr12:26636831

ENST00000242737

378_434

182.0

Domain

MIR 5

Tgene

ITPR2

chr8:71550783

chr12:26636831

ENST00000242737

265_269

182.0

Region

Inositol 1%2C4%2C5-trisphosphate binding

Tgene

ITPR2

chr8:71550783

chr12:26636831

ENST00000242737

507_510

182.0

Region

Inositol 1%2C4%2C5-trisphosphate binding

Tgene

ITPR2

chr8:71550783

chr12:26636831

ENST00000242737

567_569

182.0

Region

Inositol 1%2C4%2C5-trisphosphate binding

Tgene

ITPR2

chr8:71550783

chr12:26636831

ENST00000242737

1_2227

182.0

Topological domain

Cytoplasmic

Tgene

ITPR2

chr8:71550783

chr12:26636831

ENST00000242737

2249_2260

182.0

Topological domain

Extracellular

Tgene

ITPR2

chr8:71550783

chr12:26636831

ENST00000242737

2282_2307

182.0

Topological domain

Cytoplasmic

Tgene

ITPR2

chr8:71550783

chr12:26636831

ENST00000242737

2329_2351

182.0

Topological domain

Extracellular

Tgene

ITPR2

chr8:71550783

chr12:26636831

ENST00000242737

2373_2394

182.0

Topological domain

Cytoplasmic

Tgene

ITPR2

chr8:71550783

chr12:26636831

ENST00000242737

2416_2521

182.0

Topological domain

Extracellular

Tgene

ITPR2

chr8:71550783

chr12:26636831

ENST00000242737

2543_2701

182.0

Topological domain

Cytoplasmic

Tgene

ITPR2

chr8:71550783

chr12:26636831

ENST00000381340

2249_2260

1937

2702.0

Topological domain

Extracellular

Tgene

ITPR2

chr8:71550783

chr12:26636831

ENST00000381340

2282_2307

1937

2702.0

Topological domain

Cytoplasmic

Tgene

ITPR2

chr8:71550783

chr12:26636831

ENST00000381340

2329_2351

1937

2702.0

Topological domain

Extracellular

Tgene

ITPR2

chr8:71550783

chr12:26636831

ENST00000381340

2373_2394

1937

2702.0

Topological domain

Cytoplasmic

Tgene

ITPR2

chr8:71550783

chr12:26636831

ENST00000381340

2416_2521

1937

2702.0

Topological domain

Extracellular

Tgene

ITPR2

chr8:71550783

chr12:26636831

ENST00000381340

2543_2701

1937

2702.0

Topological domain

Cytoplasmic

Tgene

ITPR2

chr8:71550783

chr12:26636831

ENST00000242737

2228_2248

182.0

Transmembrane

Helical

Tgene

ITPR2

chr8:71550783

chr12:26636831

ENST00000242737

2261_2281

182.0

Transmembrane

Helical

Tgene

ITPR2

chr8:71550783

chr12:26636831

ENST00000242737

2308_2328

182.0

Transmembrane

Helical

Tgene

ITPR2

chr8:71550783

chr12:26636831

ENST00000242737

2352_2372

182.0

Transmembrane

Helical

Tgene

ITPR2

chr8:71550783

chr12:26636831

ENST00000242737

2395_2415

182.0

Transmembrane

Helical

Tgene

ITPR2

chr8:71550783

chr12:26636831

ENST00000242737

2522_2542

182.0

Transmembrane

Helical

Tgene

ITPR2

chr8:71550783

chr12:26636831

ENST00000381340

2228_2248

1937

2702.0

Transmembrane

Helical

Tgene

ITPR2

chr8:71550783

chr12:26636831

ENST00000381340

2261_2281

1937

2702.0

Transmembrane

Helical

Tgene

ITPR2

chr8:71550783

chr12:26636831

ENST00000381340

2308_2328

1937

2702.0

Transmembrane

Helical

Tgene

ITPR2

chr8:71550783

chr12:26636831

ENST00000381340

2352_2372

1937

2702.0

Transmembrane

Helical

Tgene

ITPR2

chr8:71550783

chr12:26636831

ENST00000381340

2395_2415

1937

2702.0

Transmembrane

Helical

Tgene

ITPR2

chr8:71550783

chr12:26636831

ENST00000381340

2522_2542

1937

2702.0

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

ITPR2

chr8:71550783

chr12:26636831

ENST00000381340

112_166

1937

2702.0

Domain

MIR 1

Tgene

ITPR2

chr8:71550783

chr12:26636831

ENST00000381340

173_223

1937

2702.0

Domain

MIR 2

Tgene

ITPR2

chr8:71550783

chr12:26636831

ENST00000381340

231_287

1937

2702.0

Domain

MIR 3

Tgene

ITPR2

chr8:71550783

chr12:26636831

ENST00000381340

294_372

1937

2702.0

Domain

MIR 4

Tgene

ITPR2

chr8:71550783

chr12:26636831

ENST00000381340

378_434

1937

2702.0

Domain

MIR 5

Tgene

ITPR2

chr8:71550783

chr12:26636831

ENST00000381340

265_269

1937

2702.0

Region

Inositol 1%2C4%2C5-trisphosphate binding

Tgene

ITPR2

chr8:71550783

chr12:26636831

ENST00000381340

507_510

1937

2702.0

Region

Inositol 1%2C4%2C5-trisphosphate binding

Tgene

ITPR2

chr8:71550783

chr12:26636831

ENST00000381340

567_569

1937

2702.0

Region

Inositol 1%2C4%2C5-trisphosphate binding

Tgene

ITPR2

chr8:71550783

chr12:26636831

ENST00000381340

1_2227

1937

2702.0

Topological domain

Cytoplasmic

Top

Fusion Gene Sequence for LACTB2-ITPR2

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>43825_43825_1_LACTB2-ITPR2_LACTB2_chr8_71550783_ENST00000522447_ITPR2_chr12_26636831_ENST00000381340_length(transcript)=5160nt_BP=877nt
TTCCGCGCTGGAGTATCCAGATAGGCGACACGCCGGCGGGCGGCTGAGGCGGGAATGGCTGCTGTACTGCAGCGCGTCGAGCGGCTGTCC
AATCGAGTCGTGCGTGTGTTGGGCTGTAACCCGGGTCCCATGACCCTCCAAGGCACCAACACCTACCTAGTGGGGACCGGCCCCAGGAGA
ATCCTCATTGACACTGGAGAACCAGCAATTCCAGAATACATCAGCTGTTTAAAGCAGGCTCTAACTGAATTTAACACAGCAATCCAGGAA
ATTGTAGTGACTCACTGGCACCGAGATCATTCTGGAGGCATAGGAGATATTTGTAAAAGCATCAATAATGACACTACCTATTGCATTAAA
AAACTCCCACGGAATCCTCAGAGAGAAGAAATTATAGGAAATGGAGAGCAACAATATGTTTATCTGAAAGATGGAGATGTGATTAAGACT
GAGGGAGCCACTCTAAGAGTTCTATATACCCCTGGCCACACTGATGATCACATGGCTCTACTCTTAGAAGAGGAAAATGCTATCTTTTCT
GGAGATTGCATCCTAGGGGAAGGAACAACGGTATTTGAAGACCTCTATGATTATATGAACTCTTTAAAAGAGTTATTGAAAATCAAAGCT
GATATTATATATCCAGGACATGGCCCAGTAATTCATAATGCTGAAGCTAAAATTCAACAATACATTTCTCACAGAAATATTCGAGAGCAG
CAAATTCTTACATTATTTCGTGAGAACTTTGAGAAATCATTTACAGTAATGGAGCTTGTAAAAATTATTTACAAGAATACTCCTGAGAAT
TTACATGAAATGGCTAAACATAATCTCTTACTTCATTTGAAAAAACTAGAAAAAGAAGGAAAAATATAACTTCTTGAGGAATCAAAACAA
CAAAACAAATTACAACCTAGTCTGTGAGACCCTTCAGTTTCTGGACTGCATTTGTGGAAGTACAACCGGTGGCCTGGGCCTGTTGGGTCT
CTACATCAATGAGAAGAATGTAGCGCTGGTCAACCAGAACCTGGAGAGCTTGACTGAGTATTGCCAGGGCCCTTGCCATGAAAATCAGAC
CTGTATCGCTACACATGAGTCTAATGGGATTGATATCATCATTGCTTTGATTCTGAATGACATAAACCCTCTTGGTAAATACCGAATGGA
CCTGGTGCTCCAGCTAAAGAACAATGCATCTAAACTTTTGCTGGCCATTATGGAAAGCAGACATGACAGTGAGAATGCAGAAAGAATTCT
TTTTAACATGAGACCCAGAGAACTGGTGGATGTGATGAAGAATGCCTATAACCAAGGATTGGAATGTGACCATGGGGATGATGAGGGTGG
AGATGATGGTGTTTCTCCAAAAGATGTTGGACACAATATCTATATTCTGGCCCATCAGTTGGCCCGCCACAATAAACTGTTGCAGCAGAT
GCTCAAACCAGGATCGGATCCAGATGAAGGAGATGAAGCCTTAAAGTATTATGCCAACCACACTGCACAGATTGAGATTGTCCGGCATGA
TAGGACCATGGAACAAATAGTTTTTCCTGTCCCCAATATATGTGAATACCTCACTCGAGAATCCAAGTGCCGTGTGTTCAATACAACTGA
AAGGGATGAACAAGGAAGTAAAGTGAATGACTTTTTCCAGCAAACAGAAGATCTCTACAATGAAATGAAGTGGCAGAAGAAAATCAGGAA
TAACCCTGCACTGTTCTGGTTCTCGAGGCACATCTCTCTCTGGGGGAGCATTTCCTTCAACCTGGCTGTGTTCATCAATTTAGCTGTTGC
TCTCTTCTACCCATTTGGGGATGATGGAGATGAAGGTACACTTTCTCCATTGTTCTCGGTTCTTCTTTGGATAGCAGTTGCGATCTGCAC
ATCTATGCTGTTTTTCTTCTCCAAGCCTGTGGGTATTCGGCCGTTTCTTGTATCAATAATGCTCAGATCAATATATACAATAGGTCTTGG
GCCTACATTAATACTTCTTGGTGCAGCTAATCTTTGTAATAAAATTGTTTTTCTGGTGAGTTTTGTTGGAAATCGTGGCACGTTCACCCG
TGGGTACCGAGCAGTCATCCTGGATATGGCCTTTCTCTATCACGTGGCGTATGTCCTGGTTTGCATGCTGGGCCTTTTTGTCCATGAATT
CTTCTATAGCTTCCTGCTTTTTGATTTGGTGTACAGGGAAGAGACTTTGCTGAATGTCATAAAAAGTGTCACACGAAATGGCCGCTCTAT
TATTCTAACTGCAGTCCTGGCTCTCATCCTCGTCTACCTGTTTTCCATTATTGGGTTCCTTTTTTTGAAGGATGACTTCACTATGGAAGT
TGATAGGCTGAAAAACCGAACTCCTGTTACAGGCAGTCATCAAGTGCCTACTATGACTTTAACTACCATGATGGAAGCATGTGCCAAGGA
GAACTGTTCACCCACAATTCCAGCTTCAAATACAGCTGATGAAGAGTATGAAGATGGAATTGAAAGGACGTGTGACACTCTCCTTATGTG
CATTGTCACCGTGCTGAACCAGGGCCTCAGGAATGGCGGTGGTGTGGGGGATGTGCTAAGAAGGCCATCGAAAGATGAGCCCTTGTTTGC
TGCCCGAGTGGTTTATGACCTTCTTTTTTATTTCATTGTTATCATTATTGTTCTGAACTTGATTTTTGGTGTTATCATCGATACTTTTGC
TGATCTCAGAAGCGAAAAACAGAAAAAAGAAGAAATTCTAAAGACAACTTGTTTCATCTGTGGACTTGAGAGAGACAAGTTTGATAATAA
AACGGTTTCATTTGAGGAGCACATTAAGTCAGAACACAATATGTGGCATTATTTGTACTTCATAGTCCTGGTGAAAGTTAAAGACCCAAC
AGAATACACTGGACCTGAAAGTTATGTGGCTCAAATGATTGTGGAGAAGAATTTGGATTGGTTTCCTCGGATGCGAGCCATGTCCCTCGT
TAGCAATGAAGGCGACAGTGAGCAAAATGAAATTCGGAGCCTTCAGGAGAAGTTGGAATCGACCATGAGTCTGGTCAAACAGCTGTCGGG
TCAGCTGGCGGAGCTCAAGGAGCAGATGACAGAACAAAGGAAGAATAAGCAGAGACTGGGCTTCCTCGGATCAAACACACCCCATGTGAA
TCATCACATGCCACCACACTGATACCATGGGGGGAAGCCGTGACTAGCCTTTCATCAGTGTCCTGCCTGATCACTGAATAAAGAACTGAG
ATGGAGGGGAGTGAACAGTGCCTATTGTTGAAAAGTTAAAAACAACCAAGTGCCAAGATGTTGAGTGGGTTAGCTCCGAGAACAATTTAT
AACTGTGTTTTCATGGTTGCGAAGACCTAACCTCAAATGCATCTGCTAGAAAGCGTACATCACACATTCGCAATGCATCAGGAAGAAAAG
GCTTGCCCAAAAGGCTGGAGAGGGCAGGGAGCGGCAGGATGGAAGGAGACACGGGGCAGGGAGAACTCTCTTCTGCTAAATCGATAGGAG
TCAGTTTTGTCTTAAATGCTGACTACAGCCACTGACATGGTTGGCTGGAATTTCTTTCTTTTAATTGTGGCATATAGGTTTGTGACACAA
GAAGTCATACTTTGGTGGCTAAGTTTTACTAAGGAAAATAACTGAAAAGATTAAAAGTGAGAGCTGAAAAGAGAAATGATAATGCTTCCA
AACTGTAGCTGTCACAGGGCAATTTCTTTATTTATAACATGAAGCACAATGGATTTACAGCTCTAGGAACTTAGTACTTTGGAGCTTTTG
CCTCTCACACTGACAACATAACAGGATGTGATTGCCTTCTCTGGGATTCAGACAGGCTCTGTCAATGTGGAGCACAAAAGGAGATTTTCA
TATAACTTGTTAAAAACATGTTCTAAGTCATGTATAGGCTAAGATTTTAAGAAGATCTGGGGGAATAAAAAGCCAACAGTAAGCCCCAGG
AAAGGGTTTTTTGAGACCATATGTATGCTATTAAAATATATTGAGATTAATACATGAAAATGCTTAAAAGTGATAGGAATTATTGAGAAA
CTTATGATGGTGGCATTGCCTTTTATAAACATGGAGTGAAAGCCATTTGACTCAACGTTTGCTGTGCTTAAAGAATTGCTTCAGGACCCG
AGCGTTTTTATGTATGCTGTTCCTGCAGTTAGGAAAAAAAAATCCAAGAAATGTATTGAATACTCAAGAAAATGCCACATTTCAATTACA
TATTTAAAACTGTATCTGTAAGGGCTTTTCAAAATGTAGCAAGATAAAAATCTCTTATTCAAATTGTTTTTGTATTAAATCATGCACTCA
GAATTTGTCGAGGGAGAGAATAACCTGGTGTGTTCAGGTTATTCTTAGAGACTACACATTTGGAATAGCAGAGCAAAATATGGATAATGA
AAGTGTTGGGAAAAAAGTGATGTGACAGGGAGTGAAGACACTTGATACCAGACTCTGGGAGATACTCTGCAAGTTGACCTGGCCTCTCCC
CCACAGGAACAAAACACTGCCTCCAGAGTCTTTAAATTCTCAGTTATCAACGCCAAGGTTTAAGGTCTAGATAGGGTTTGCTATAGGGTT
TGCTCTGACAATTTTTAAAGCTTTTGGATTGTTCTAACATAGCTTAAGCTATTGGTTCCTAAAAATCCCAAATCAAGATCTATGTAGAAT
ATAAAGGAAGCCTGAACCAATCCTTCCACATACTGTTAAGATGTAGACTTGGAACAAAGCTGTTGGGACCCAGAGCAATGAATTTTTGAA
CTGAAGCTACTGGTACTCCCCAGCACCACCTCATACTAAGAATTCCTCACTCTGACATGACAGTATTTTTTCTGACCAGGAGCTGAAAGA
CCCTGACATTCATGATCCAAAGATATAAGAAATTTTGATATGTCTGCATGCAGCACAGAACTTTGAACCTAGGAGGCAGTCAATAAATAC
ATGAGAAATTCAGCTGTCATTCAGTTACTCTTAATTCTTTATAAAACTTTAAATGATACCACATATTTGTTTGTTTAAAATGGCTTTCCC
AAAATCAAAGTAGACTAAAGCAGCCATCTTTAAAATCCAGGATCATCAATGCTATTAACAGTATCAGGTAAAAAGTACACTTTAAAATAT

>43825_43825_1_LACTB2-ITPR2_LACTB2_chr8_71550783_ENST00000522447_ITPR2_chr12_26636831_ENST00000381340_length(amino acids)=762AA_BP=
MRNQNNKTNYNLVCETLQFLDCICGSTTGGLGLLGLYINEKNVALVNQNLESLTEYCQGPCHENQTCIATHESNGIDIIIALILNDINPL
GKYRMDLVLQLKNNASKLLLAIMESRHDSENAERILFNMRPRELVDVMKNAYNQGLECDHGDDEGGDDGVSPKDVGHNIYILAHQLARHN
KLLQQMLKPGSDPDEGDEALKYYANHTAQIEIVRHDRTMEQIVFPVPNICEYLTRESKCRVFNTTERDEQGSKVNDFFQQTEDLYNEMKW
QKKIRNNPALFWFSRHISLWGSISFNLAVFINLAVALFYPFGDDGDEGTLSPLFSVLLWIAVAICTSMLFFFSKPVGIRPFLVSIMLRSI
YTIGLGPTLILLGAANLCNKIVFLVSFVGNRGTFTRGYRAVILDMAFLYHVAYVLVCMLGLFVHEFFYSFLLFDLVYREETLLNVIKSVT
RNGRSIILTAVLALILVYLFSIIGFLFLKDDFTMEVDRLKNRTPVTGSHQVPTMTLTTMMEACAKENCSPTIPASNTADEEYEDGIERTC
DTLLMCIVTVLNQGLRNGGGVGDVLRRPSKDEPLFAARVVYDLLFYFIVIIIVLNLIFGVIIDTFADLRSEKQKKEEILKTTCFICGLER
DKFDNKTVSFEEHIKSEHNMWHYLYFIVLVKVKDPTEYTGPESYVAQMIVEKNLDWFPRMRAMSLVSNEGDSEQNEIRSLQEKLESTMSL

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for LACTB2-ITPR2

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for LACTB2-ITPR2

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for LACTB2-ITPR2

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source