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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:LACTB-RAB8B (FusionGDB2 ID:43828)

Fusion Gene Summary for LACTB-RAB8B

Fusion gene summary

Fusion gene information	Fusion gene name: LACTB-RAB8B
	Fusion gene ID: 43828
		Hgene	Tgene
	Gene symbol	LACTB	RAB8B
	Gene ID	114294	51762
	Gene name	lactamase beta	RAB8B, member RAS oncogene family
	Synonyms	G24\|MRPL56	-
	Cytomap	15q22.2	15q22.2
	Type of gene	protein-coding	protein-coding
	Description	serine beta-lactamase-like protein LACTB, mitochondrialmitochondrial 39S ribosomal protein L56serine beta-lactamase-like protein, mitochondrial	ras-related protein Rab-8BRAB-8b protein
	Modification date	20200313	20200313
	UniProtAcc	P83111	.
	Ensembl transtripts involved in fusion gene	ENST00000261893, ENST00000413507,	ENST00000321437, ENST00000448330,
Fusion gene scores	* DoF score	2 X 2 X 2=8	5 X 3 X 5=75
	# samples	2	6
	** MAII score	log2(2/8*10)=1.32192809488736	log2(6/75*10)=-0.321928094887362 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: LACTB [Title/Abstract] AND RAB8B [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	LACTB(63421849)-RAB8B(63536955), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	LACTB	GO:0006508	proteolysis	28329758
Hgene	LACTB	GO:0019216	regulation of lipid metabolic process	28329758
Tgene	RAB8B	GO:0045046	protein import into peroxisome membrane	18346465

Fusion gene breakpoints across LACTB (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across RAB8B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	SARC	TCGA-QC-A6FX-01A	LACTB	chr15	63421849	+	RAB8B	chr15	63536955	+

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Fusion Gene ORF analysis for LACTB-RAB8B

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
Frame-shift	ENST00000261893	ENST00000321437	LACTB	chr15	63421849	+	RAB8B	chr15	63536955	+
Frame-shift	ENST00000261893	ENST00000448330	LACTB	chr15	63421849	+	RAB8B	chr15	63536955	+
In-frame	ENST00000413507	ENST00000321437	LACTB	chr15	63421849	+	RAB8B	chr15	63536955	+
In-frame	ENST00000413507	ENST00000448330	LACTB	chr15	63421849	+	RAB8B	chr15	63536955	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000413507

LACTB

chr15

63421849

ENST00000321437

RAB8B

chr15

63536955

6520

1857

998

324

ENST00000413507

LACTB

chr15

63421849

ENST00000448330

RAB8B

chr15

63536955

3075

1857

998

324

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000413507	ENST00000321437	LACTB	chr15	63421849	+	RAB8B	chr15	63536955	+	0.000200413	0.99979955
ENST00000413507	ENST00000448330	LACTB	chr15	63421849	+	RAB8B	chr15	63536955	+	0.000556636	0.99944335

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Fusion Genomic Features for LACTB-RAB8B

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
LACTB	chr15	63421849	+	RAB8B	chr15	63536954	+	4.99E-07	0.9999995
LACTB	chr15	63421849	+	RAB8B	chr15	63536954	+	4.99E-07	0.9999995

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for LACTB-RAB8B

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr15:63421849/chr15:63536955)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
LACTB P83111	.
FUNCTION: Mitochondrial serine protease that acts as a regulator of mitochondrial lipid metabolism (PubMed:28329758). Acts by decreasing protein levels of PISD, a mitochondrial enzyme that converts phosphatidylserine (PtdSer) to phosphatidylethanolamine (PtdEtn), thereby affecting mitochondrial lipid metabolism (PubMed:28329758). It is unclear whether it acts directly by mediating proteolysis of PISD or by mediating proteolysis of another lipid metabolism protein (PubMed:28329758). Acts as a tumor suppressor that has the ability to inhibit proliferation of multiple types of breast cancer cells: probably by promoting decreased levels of PISD, thereby affecting mitochondrial lipid metabolism (PubMed:28329758). {ECO:0000269\|PubMed:28329758}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

RAB8B

chr15:63421849

chr15:63536955

ENST00000321437

121_124

208.0

Nucleotide binding

GTP

Tgene

RAB8B

chr15:63421849

chr15:63536955

ENST00000321437

63_67

208.0

Nucleotide binding

GTP

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

RAB8B

chr15:63421849

chr15:63536955

ENST00000321437

37_45

208.0

Motif

Effector region

Tgene

RAB8B

chr15:63421849

chr15:63536955

ENST00000321437

15_22

208.0

Nucleotide binding

GTP

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Fusion Gene Sequence for LACTB-RAB8B

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>43828_43828_1_LACTB-RAB8B_LACTB_chr15_63421849_ENST00000413507_RAB8B_chr15_63536955_ENST00000321437_length(transcript)=6520nt_BP=1857nt
GTGCGTGAGTTTGGTGGCGGCCGGCTGTGCAGAGACGCCATGTACCGGCTCATGTCAGCAGTGACTGCCCGGGCTGCCGCCCCCGGGGGC
TTGGCCTCAAGCTGCGGACGACGCGGGGTCCATCAGCGCGCCGGGCTGCCGCCTCTCGGCCACGGCTGGGTCGGGGGCCTCGGGCTGGGG
CTGGGGCTGGCGCTCGGGGTGAAGCTGGCAGGTGGGCTGAGGGGCGCGGCCCCGGCGCAGTCCCCCGCGGCCCCCGACCCTGAGGCGTCG
CCTCTGGCCGAGCCGCCACAGGAGCAGTCCCTCGCCCCGTGGTCTCCGCAGACCCCGGCGCCGCCCTGCTCCAGGTGCTTCGCCAGAGCC
ATCGAGAGCAGCCGCGACCTGCTGCACAGGATCAAGGATGAGGTGGGCGCACCGGGCATAGTGGTTGGAGTTTCTGTAGATGGAAAAGAA
GTCTGGTCAGAAGGTTTAGGTTATGCTGATGTTGAGAACCGTGTACCATGTAAACCAGAGACAGTTATGCGAATTGCTAGCATCAGCAAA
AGTCTCACCATGGTTGCTCTTGCCAAATTGTGGGAAGCAGGGAAACTGGATCTTGATATTCCAGTACAACATTATGTTCCCGAATTCCCA
GAAAAAGAATATGAAGGTGAAAAGGTTTCTGTCACAACAAGATTACTGATTTCCCATTTAAGTGGAATTCGTCATTATGAAAAGGACATA
AAAAAGGTGAAAGAAGAGAAAGCTTATAAAGCCTTGAAGATGATGAAAGAGAATGTTGCATTTGAGCAAGAAAAAGAAGGCAAAAGTAAT
GAAAAGAATGATTTTACTAAATTTAAAACAGAGCAGGAGAATGAAGCCAAATGCCGGAATTCAAAACCTGGCAAGAAAAAGAATGATTTT
GAACAAGGCGAATTATATTTGAGAGAAAAGTTTGAAAATTCAATTGAATCCCTAAGATTATTTAAAAATGATCCTTTGTTCTTCAAACCT
GGTAAATGAATACCTTCTGCTGTGTCTAGCTATATCGCATCTTAACACTATTTTATTAATTAAAAGTCAAATTTTCTTTGTTTCCATTCC
AAAATCAACCTGCCACATTTTGGGAGCTTTTCTACATGTCTGTTTTCTCATCTGTAAAGTGAAGGAAGTAAAACATGTTTATAAAGTACA
CTAAGACCCTTTGATGAAAGATAGCAATAATATTAATAATTCAAACATGAATAACTAAACCAAAATTGCACCCACCATGAGCATCTGTAA
TTTGCTCTTTAACCATTCCTTTTTTAGGTTTTAACTAATACTTTGTTTACGTGTTATTAGTTTTTAATTGTTTTCATACTGTTTTGAAAT
AATTTTATACTTATAGAAAAGTTGCAAGAGTAGTACAAAGGATTCACATATCCTCTTTACTCAGATTCCCTTAATGTTAGTTTACCGCAT
TTGCATTACCTTTCTGTCTACATATGTGTTTGTTTCTGAACCATTTGGAAATAAGTTGTAGACGTGATACCCCTTTACCTATAAATATTT
ACATGTGTATTTTCTAAAAACAAGGACATTCAGGGCCGGGTGCAGTGGCTCACGCCTGTAATCCCAACACTTTGGAAGGCCGAGGTGGGT
GGATCACCTGAGGTCAGGAGTTCAAGACCAGCCTGGCCAATGTGGTGAAATCAACCCTCTCTCTACTAAAAATGCAAAAATTAGCCAGGT
GTGGTGGCGGGTGCCTATAATCCCAGCCACGCGGGAGGCTGAGGCAGGAGAATCGCTTGAACCCAGGAGGTGGAGTTGCAGTAAGCCAAG
ATCGTGCCCCTGCACTTCAGGCTGGGCGAAAGAGTGAGACTCCATGTCAAAAAAGGAGAATTGATTTTAAAATTAGAACGATAGAACTAG
ATGGAAAGAAAATTAAGCTTCAGATATGGGACACAGCGGGTCAGGAAAGATTCCGAACAATCACGACAGCGTACTACAGAGGAGCCATGG
GCATTATGCTGGTCTATGACATCACAAATGAAAAATCCTTTGACAATATTAAAAATTGGATCAGAAACATTGAAGAGCATGCCTCTTCCG
ATGTCGAAAGAATGATCCTGGGTAACAAATGTGATATGAATGACAAAAGACAAGTGTCAAAAGAAAGAGGGGAGAAGCTAGCAATTGACT
ATGGGATTAAATTCTTGGAGACAAGCGCAAAATCCAGTGCAAATGTAGAAGAGGCATTTTTTACACTTGCACGAGATATAATGACAAAAC
TCAACAGAAAAATGAATGACAGCAATTCAGCAGGAGCAGGTGGACCAGTGAAAATAACAGAAAACCGATCAAAGAAGACCAGTTTCTTTC
GTTGCTCGCTACTTTGATGAACTCTTTCTGAGAGACTGCAGCACACCTAGAGGGCCCTTTCCTGCTTCTCTGAAAGCACAGGTCACCCAG
CCTCAGAATCACACCTCCCGGCTGCTGCTGAGAGCACCACTGAACTTAGACCTCTCAACACAGTATGCCAAGTGGATTCCAGCCTCATGG
CCTAGCAAAAGAACAGACTCCCTTTTTCAAACATGGAAGCAATGAAGTGGAGACACATGCAGGACCTAACTCGTTTTTTCCTTGTTTTAT
TACCTGTTGCAGAAGCGGTTATCTTTCTTTTTTACTTTGCACATCAGTGTTAGCCTTTCCCTATTTCAGCACAATCTTAGACTCATATTT
GCACACTTTTGTGTCGTGAAGTTCTAGACAAATTTGTACATGTGGCAATGTTAAAAGAGCATTTACAGCAGAGGTTAATATACTAAAATT
AAAGGGTATTTGGTCTGGTTCATATGGTCAAATATTACTGCCTTGGTAGCATTTATTTAAGGGCTTTTTCTTAAATAAGAATCATTAAAG
TCATTAAAAAAATTTACTGAAATGCCCATCTTGTCATCAAAGGCCACAATTTCTTTATTTCTTCAGATTAAGAGCTTTGCCTCATCCCCG
ACCTGTTTTCCAGAGTCTGGGTAGCTGAATGAATCACTTTAAAATGATTACCTCTGCCTAATCTATAGAAACTGCATTTGGAAATCACCA
TAATCTCATTTTTCCCTGGGGTTTGTATTTGCTATTCTTTCCCATGTTTGACTTAAGTGTAATCACTCTTAAGTAATATTTGAACATTAT
TATCTGTTTCTATTTGTGAACTTCTTGAGCTGAAATTTTACGTGGGCTGAGAGATATACCATTTAGGGTTTTAGTGCAGCATCTAACTGT
GATTCTGTCAATAAGGATATGTAATATATTTTTTCTTAGGTTCACTCCTTAGCTGGCTGGTTTAGTTGTAATACCAAATTCCTACCATAA
TCCCTGTCTACAAAAGTTAGGTTTAGATTTTAGTTTGCGGAAACCTTCCCTATATAGAGACAGATTAACTTGTTGATATAAATTTAATAG
AGCTAGCTCTTGGTAATGGTGAAAATAATGAGTTTTGGTTGGTTTTATTTGGCAGATGTTTTTAGAAATAAAAGTACTTAGACCTAGTGC
AGCCTCTAGGAAAAGTCTTGCCTTTTCATTAGAGAAAACAGGACCAAGGTTTCAGTTTTCAAACAGCTGTTGTTGATTGTGTAGAACCCA
GTTCCATCTGTTTTGGTTCATTGTTACAGAACTTAGTCCAGTCATTTGGGCTAAAGCCAACCAAAAGCTTAGTTGCCTTTCTCAACAAAC
ACTGGTACTGGTATACTTTTGTAGATGAAACCATCACAAGGTATTTAGTGTTAACTTGTGTGCCAAATTCAGATCACTATGTCGTTGTTG
CTCTAGCCTTCAGTGTCATAACACAGGGGGGATAAAACAGAGGGGATGAGGGAAATGAATTCTGTTAATAATTATTCTTCCTGGTATGCC
TGTTTTGCTTCACAAAGGCTACTATCATGCTGGATAGATAAGAACAGGAGATGGCAGTGGAAAGGGATTGCTTGTTACCACAGAGAATTC
TCTTCAAATTAAGATATGTCATTAGAATGCTTGGACCAGTCAATCTTTTGTACTTATTTGAAAATATAGGAACAATTTAGCAGCTGCAAA
TATGCCCAAGCTATTTTTAATAGATATACTAAACTTATTGTTGACAAATTTCAGCCTCCTTAATTTTTTTTTTTTTGGTAATTACCTATA
GGCTTAAAAGTCATTCGTTGCTGTTCTAGTATAATTAGTAGTTCCGTGATTGAAAGTTTATTGTAATTCTACTATCTTCAAATTAGATAC
ATTTTCAAAAGGAAAAGATAATTTTTTAGAAACATCTTAATATTCACTATTTCCTGAAAAAATCCAAGCAGTTAACGCTTTCTGGATGGT
AACAAAGTACCTTCTAAAAGATAAGTGCTATGACACCATGTATGAATGTAATTCTCTTAGTAATTTACCTCTGACTATTTGGTGTCTTAA
CGCTTTGGTTTATATAATCTCAGGGGTTGTCTGCAAACCAAAACTGACATATTCTGTGGTTAGCTTTTATTACTTTTTTTTTTAACAGAA
TGCTTTGCTTTGGTTATATTTCTTCTTTCTTCTTTTGTCTTATATGGATTAATAACTAGTCTCCATGAACTTCACTTGAAAGAGCCTGTA
AAAGTTAGATGAGTCTAAAAGTGCTCTTTGAAGTAGCAGCAAATTGGGAGTATATGCTCTGTTATATAGAAATAAATTGTCCTTGCTATT
TTCTTACATTTAGCTTTGCTAGATTGTATATACATTGAGCTAAGACCTTAGGAAATTCACTTTCTGCATGATAAAATGACCCAATAAATA
TTCCACTTTGCTTAATAATGTACATACAGTGCATTATTTTTTCTATTTGTAGATGAATTTAATGACAGATAATTGTCTGTTCCCCGCTGA
AACTGAAGAAATCTAGTTTTTTTGTGAACATTTTTGTGGTCTTATGGATAAGGTACATGAAGATTTTTGCAGCAGTATTAGTGGTTCAGT
GGCTGCACTTTATTAATCAGTGTGTTAATTTTTGACAGTGATTGGACTAGACCTTTTCAAATAGAGTCTGAGGGTATCAGACAGTGAAAA
TGTGCTGTAACTAAGTAGCATGTAAATCAGTTGATTGTAAAACGTTTCGCTGGGAACTTATTTTAGCTATATTTTACTTCAGACAGATTA
TGATACAATAATCTACCTGTGCATCAGTTAGTAGGTGCTGCAGGGTTTCTTACTATTTACAGAAACATTTTGTGCAGTCTTTGTTATAAA
TTTTCAGAAGACTATACTCTTTACTTTGAAGGTCTATTTTTTAATTATACCTCATTTAGCTAACTAGTATTCTAATACCTGGTAGAAAAA
CAGTGAGCCAGCCTTTAAGCATCTAACAAAATTTAGACTCTTTGTTTTGTTTTGAACTGAAGACATCATTGGGAAAGGTAGGAAATATTA
GTTTAGGATAGAGCATACATGTCATATCCAGTAGCATAAAAAAAGTATTATCTCCCTGTCTCCATTAATAAATTTAGCTGTGCAATATAG
GTGCGTTTTTGCAGAAGTTTCTAGTAAGAGATTATAACTCCATTTTACAGGTTCTGAATGCTCAGAGTCTATATTAAGGCTTATAAAGTT
TTTCCTGTGATCAGTAAGTGACACATTTAAGCAGACATTCTTTTCAAGTTCATGACTTAGATTCCTTTACAAATTTAGTTCTCAATCTTT
AAAAACCACATTTCATTATGTTGGTTAATTATTATAAATTTTAAGCACTCATTTCTGCAATCAGGTTTCTCAGAATTTTTTTTTTTTAAA
CAGAAGAGACATTCCTTTTTCCTTGTTACATCCAAGGGGGGCACAGGGGTGGGTGGAAAGGAATGTCTAAAAATGAAATCCCTTGATATA
GAGGGACCTAGACGGACAGGATATGCTAAAATAATTTCAAATTCTAGCACAATTTTAGAGTAGAATAAGTCATTTTTTTAGACTAATAAA
ATTAATGGCTGTCATGTTCACTCTGAAAAAAATCTAAATGACTGAAATGTACAGAAATAAAAATTAGCAAACAATTATTCTAGGGATATT
TTCAGATTTTACTTCATTTCTTGAAATGCGTGTGCCATATGCAATTGCATTTCTTGTGCCAAGAAACTAATAGAACTTATTTCACTTTAC
CTTTTTTTAAAATGTGAATTTAGTTATTATAGTTCAATTTTATGGCCTTACAGATGGCTTTTATTTTGTTTGCAGCTGACACTGCAGTTC
CTTTCATGCAAAATACCATAAACTGTTTGATGAAAATCATGCCCCTAATGGAAACTCTCTAGTTTTTCCATATAACTATCCTACTGTACA
TGTTTAAACATATTTTATTTTTGCTCCAATGGCTTAATGTGAAAAGCTCCTGCAGATAAGTGGACCTGTCATGTGGTTAATCTTGTTTAA
GCCAATTCATTAACTGTGTACTGATACTGATGCTATGTTTTTTTTAAATGGATTTTATTCCAGGTGAACTTTTTTTTTATAATAATGTTC

>43828_43828_1_LACTB-RAB8B_LACTB_chr15_63421849_ENST00000413507_RAB8B_chr15_63536955_ENST00000321437_length(amino acids)=324AA_BP=
MCRDAMYRLMSAVTARAAAPGGLASSCGRRGVHQRAGLPPLGHGWVGGLGLGLGLALGVKLAGGLRGAAPAQSPAAPDPEASPLAEPPQE
QSLAPWSPQTPAPPCSRCFARAIESSRDLLHRIKDEVGAPGIVVGVSVDGKEVWSEGLGYADVENRVPCKPETVMRIASISKSLTMVALA
KLWEAGKLDLDIPVQHYVPEFPEKEYEGEKVSVTTRLLISHLSGIRHYEKDIKKVKEEKAYKALKMMKENVAFEQEKEGKSNEKNDFTKF

--------------------------------------------------------------
>43828_43828_2_LACTB-RAB8B_LACTB_chr15_63421849_ENST00000413507_RAB8B_chr15_63536955_ENST00000448330_length(transcript)=3075nt_BP=1857nt
GTGCGTGAGTTTGGTGGCGGCCGGCTGTGCAGAGACGCCATGTACCGGCTCATGTCAGCAGTGACTGCCCGGGCTGCCGCCCCCGGGGGC
TTGGCCTCAAGCTGCGGACGACGCGGGGTCCATCAGCGCGCCGGGCTGCCGCCTCTCGGCCACGGCTGGGTCGGGGGCCTCGGGCTGGGG
CTGGGGCTGGCGCTCGGGGTGAAGCTGGCAGGTGGGCTGAGGGGCGCGGCCCCGGCGCAGTCCCCCGCGGCCCCCGACCCTGAGGCGTCG
CCTCTGGCCGAGCCGCCACAGGAGCAGTCCCTCGCCCCGTGGTCTCCGCAGACCCCGGCGCCGCCCTGCTCCAGGTGCTTCGCCAGAGCC
ATCGAGAGCAGCCGCGACCTGCTGCACAGGATCAAGGATGAGGTGGGCGCACCGGGCATAGTGGTTGGAGTTTCTGTAGATGGAAAAGAA
GTCTGGTCAGAAGGTTTAGGTTATGCTGATGTTGAGAACCGTGTACCATGTAAACCAGAGACAGTTATGCGAATTGCTAGCATCAGCAAA
AGTCTCACCATGGTTGCTCTTGCCAAATTGTGGGAAGCAGGGAAACTGGATCTTGATATTCCAGTACAACATTATGTTCCCGAATTCCCA
GAAAAAGAATATGAAGGTGAAAAGGTTTCTGTCACAACAAGATTACTGATTTCCCATTTAAGTGGAATTCGTCATTATGAAAAGGACATA
AAAAAGGTGAAAGAAGAGAAAGCTTATAAAGCCTTGAAGATGATGAAAGAGAATGTTGCATTTGAGCAAGAAAAAGAAGGCAAAAGTAAT
GAAAAGAATGATTTTACTAAATTTAAAACAGAGCAGGAGAATGAAGCCAAATGCCGGAATTCAAAACCTGGCAAGAAAAAGAATGATTTT
GAACAAGGCGAATTATATTTGAGAGAAAAGTTTGAAAATTCAATTGAATCCCTAAGATTATTTAAAAATGATCCTTTGTTCTTCAAACCT
GGTAAATGAATACCTTCTGCTGTGTCTAGCTATATCGCATCTTAACACTATTTTATTAATTAAAAGTCAAATTTTCTTTGTTTCCATTCC
AAAATCAACCTGCCACATTTTGGGAGCTTTTCTACATGTCTGTTTTCTCATCTGTAAAGTGAAGGAAGTAAAACATGTTTATAAAGTACA
CTAAGACCCTTTGATGAAAGATAGCAATAATATTAATAATTCAAACATGAATAACTAAACCAAAATTGCACCCACCATGAGCATCTGTAA
TTTGCTCTTTAACCATTCCTTTTTTAGGTTTTAACTAATACTTTGTTTACGTGTTATTAGTTTTTAATTGTTTTCATACTGTTTTGAAAT
AATTTTATACTTATAGAAAAGTTGCAAGAGTAGTACAAAGGATTCACATATCCTCTTTACTCAGATTCCCTTAATGTTAGTTTACCGCAT
TTGCATTACCTTTCTGTCTACATATGTGTTTGTTTCTGAACCATTTGGAAATAAGTTGTAGACGTGATACCCCTTTACCTATAAATATTT
ACATGTGTATTTTCTAAAAACAAGGACATTCAGGGCCGGGTGCAGTGGCTCACGCCTGTAATCCCAACACTTTGGAAGGCCGAGGTGGGT
GGATCACCTGAGGTCAGGAGTTCAAGACCAGCCTGGCCAATGTGGTGAAATCAACCCTCTCTCTACTAAAAATGCAAAAATTAGCCAGGT
GTGGTGGCGGGTGCCTATAATCCCAGCCACGCGGGAGGCTGAGGCAGGAGAATCGCTTGAACCCAGGAGGTGGAGTTGCAGTAAGCCAAG
ATCGTGCCCCTGCACTTCAGGCTGGGCGAAAGAGTGAGACTCCATGTCAAAAAAGGAGAATTGATTTTAAAATTAGAACGATAGAACTAG
ATGGAAAGAAAATTAAGCTTCAGATATGGGACACAGCGGGTCAGGAAAGATTCCGAACAATCACGACAGCGTACTACAGAGGAGCCATGG
GCATTATGCTGGTCTATGACATCACAAATGAAAAATCCTTTGACAATATTAAAAATTGGATCAGAAACATTGAAGAGCATGCCTCTTCCG
ATGTCGAAAGAATGATCCTGGGTAACAAATGTGATATGAATGACAAAAGACAAGTGTCAAAAGAAAGAGGGGAGAAGCTAGCAATTGACT
ATGGGATTAAATTCTTGGAGACAAGCGCAAAATCCAGTGCAAATGTAGAAGAGAATGACAGCAATTCAGCAGGAGCAGGTGGACCAGTGA
AAATAACAGAAAACCGATCAAAGAAGACCAGTTTCTTTCGTTGCTCGCTACTTTGATGAACTCTTTCTGAGAGACTGCAGCACACCTAGA
GGGCCCTTTCCTGCTTCTCTGAAAGCACAGGTCACCCAGCCTCAGAATCACACCTCCCGGCTGCTGCTGAGAGCACCACTGAACTTAGAC
CTCTCAACACAGTATGCCAAGTGGATTCCAGCCTCATGGCCTAGCAAAAGAACAGACTCCCTTTTTCAAACATGGAAGCAATGAAGTGGA
GACACATGCAGGACCTAACTCGTTTTTTCCTTGTTTTATTACCTGTTGCAGAAGCGGTTATCTTTCTTTTTTACTTTGCACATCAGTGTT
AGCCTTTCCCTATTTCAGCACAATCTTAGACTCATATTTGCACACTTTTGTGTCGTGAAGTTCTAGACAAATTTGTACATGTGGCAATGT
TAAAAGAGCATTTACAGCAGAGGTTAATATACTAAAATTAAAGGGTATTTGGTCTGGTTCATATGGTCAAATATTACTGCCTTGGTAGCA
TTTATTTAAGGGCTTTTTCTTAAATAAGAATCATTAAAGTCATTAAAAAAATTTACTGAAATGCCCATCTTGTCATCAAAGGCCACAATT
TCTTTATTTCTTCAGATTAAGAGCTTTGCCTCATCCCCGACCTGTTTTCCAGAGTCTGGGTAGCTGAATGAATCACTTTAAAATGATTAC
CTCTGCCTAATCTATAGAAACTGCATTTGGAAATCACCATAATCTCATTTTTCCCTGGGGTTTGTATTTGCTATTCTTTCCCATGTTTGA

>43828_43828_2_LACTB-RAB8B_LACTB_chr15_63421849_ENST00000413507_RAB8B_chr15_63536955_ENST00000448330_length(amino acids)=324AA_BP=
MCRDAMYRLMSAVTARAAAPGGLASSCGRRGVHQRAGLPPLGHGWVGGLGLGLGLALGVKLAGGLRGAAPAQSPAAPDPEASPLAEPPQE
QSLAPWSPQTPAPPCSRCFARAIESSRDLLHRIKDEVGAPGIVVGVSVDGKEVWSEGLGYADVENRVPCKPETVMRIASISKSLTMVALA
KLWEAGKLDLDIPVQHYVPEFPEKEYEGEKVSVTTRLLISHLSGIRHYEKDIKKVKEEKAYKALKMMKENVAFEQEKEGKSNEKNDFTKF

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Fusion Gene PPI Analysis for LACTB-RAB8B

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for LACTB-RAB8B

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for LACTB-RAB8B

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source