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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ANK3-RPS3 (FusionGDB2 ID:4383)

Fusion Gene Summary for ANK3-RPS3

check button Fusion gene summary
Fusion gene informationFusion gene name: ANK3-RPS3
Fusion gene ID: 4383
HgeneTgene
Gene symbol

ANK3

RPS3

Gene ID

288

6188

Gene nameankyrin 3ribosomal protein S3
SynonymsANKYRIN-G|MRT37S3
Cytomap

10q21.2

11q13.4

Type of geneprotein-codingprotein-coding
Descriptionankyrin-3ankyrin 3, node of Ranvier (ankyrin G)40S ribosomal protein S3IMR-90 ribosomal protein S3small ribosomal subunit protein uS3
Modification date2020031320200327
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000510382, ENST00000280772, 
ENST00000355288, ENST00000373827, 
ENST00000460468, ENST00000503366, 
ENST00000529285, ENST00000278572, 
ENST00000524851, ENST00000526608, 
ENST00000527446, ENST00000530164, 
ENST00000534440, ENST00000531188, 
Fusion gene scores* DoF score28 X 22 X 9=554417 X 19 X 5=1615
# samples 2922
** MAII scorelog2(29/5544*10)=-4.25680245212228
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(22/1615*10)=-2.87595873605663
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ANK3 [Title/Abstract] AND RPS3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointANK3(62267257)-RPS3(75115767), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneRPS3

GO:0006979

response to oxidative stress

23911537

TgeneRPS3

GO:0017148

negative regulation of translation

20217897

TgeneRPS3

GO:0031397

negative regulation of protein ubiquitination

19656744

TgeneRPS3

GO:0032079

positive regulation of endodeoxyribonuclease activity

18973764

TgeneRPS3

GO:0042769

DNA damage response, detection of DNA damage

23911537

TgeneRPS3

GO:0045739

positive regulation of DNA repair

23911537

TgeneRPS3

GO:0061481

response to TNF agonist

20041225

TgeneRPS3

GO:0070301

cellular response to hydrogen peroxide

23911537

TgeneRPS3

GO:1901224

positive regulation of NIK/NF-kappaB signaling

20041225

TgeneRPS3

GO:1902546

positive regulation of DNA N-glycosylase activity

15518571

TgeneRPS3

GO:1905053

positive regulation of base-excision repair

18973764

TgeneRPS3

GO:2001235

positive regulation of apoptotic signaling pathway

14988002


check buttonFusion gene breakpoints across ANK3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across RPS3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/AAK172736ANK3chr10

62267257

-RPS3chr11

75115767

+


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Fusion Gene ORF analysis for ANK3-RPS3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000510382ENST00000529285ANK3chr10

62267257

-RPS3chr11

75115767

+
5CDS-intronENST00000510382ENST00000278572ANK3chr10

62267257

-RPS3chr11

75115767

+
5CDS-intronENST00000510382ENST00000524851ANK3chr10

62267257

-RPS3chr11

75115767

+
5CDS-intronENST00000510382ENST00000526608ANK3chr10

62267257

-RPS3chr11

75115767

+
5CDS-intronENST00000510382ENST00000527446ANK3chr10

62267257

-RPS3chr11

75115767

+
5CDS-intronENST00000510382ENST00000530164ANK3chr10

62267257

-RPS3chr11

75115767

+
5CDS-intronENST00000510382ENST00000534440ANK3chr10

62267257

-RPS3chr11

75115767

+
In-frameENST00000510382ENST00000531188ANK3chr10

62267257

-RPS3chr11

75115767

+
intron-3CDSENST00000280772ENST00000531188ANK3chr10

62267257

-RPS3chr11

75115767

+
intron-3CDSENST00000355288ENST00000531188ANK3chr10

62267257

-RPS3chr11

75115767

+
intron-3CDSENST00000373827ENST00000531188ANK3chr10

62267257

-RPS3chr11

75115767

+
intron-3CDSENST00000460468ENST00000531188ANK3chr10

62267257

-RPS3chr11

75115767

+
intron-3CDSENST00000503366ENST00000531188ANK3chr10

62267257

-RPS3chr11

75115767

+
intron-3UTRENST00000280772ENST00000529285ANK3chr10

62267257

-RPS3chr11

75115767

+
intron-3UTRENST00000355288ENST00000529285ANK3chr10

62267257

-RPS3chr11

75115767

+
intron-3UTRENST00000373827ENST00000529285ANK3chr10

62267257

-RPS3chr11

75115767

+
intron-3UTRENST00000460468ENST00000529285ANK3chr10

62267257

-RPS3chr11

75115767

+
intron-3UTRENST00000503366ENST00000529285ANK3chr10

62267257

-RPS3chr11

75115767

+
intron-intronENST00000280772ENST00000278572ANK3chr10

62267257

-RPS3chr11

75115767

+
intron-intronENST00000280772ENST00000524851ANK3chr10

62267257

-RPS3chr11

75115767

+
intron-intronENST00000280772ENST00000526608ANK3chr10

62267257

-RPS3chr11

75115767

+
intron-intronENST00000280772ENST00000527446ANK3chr10

62267257

-RPS3chr11

75115767

+
intron-intronENST00000280772ENST00000530164ANK3chr10

62267257

-RPS3chr11

75115767

+
intron-intronENST00000280772ENST00000534440ANK3chr10

62267257

-RPS3chr11

75115767

+
intron-intronENST00000355288ENST00000278572ANK3chr10

62267257

-RPS3chr11

75115767

+
intron-intronENST00000355288ENST00000524851ANK3chr10

62267257

-RPS3chr11

75115767

+
intron-intronENST00000355288ENST00000526608ANK3chr10

62267257

-RPS3chr11

75115767

+
intron-intronENST00000355288ENST00000527446ANK3chr10

62267257

-RPS3chr11

75115767

+
intron-intronENST00000355288ENST00000530164ANK3chr10

62267257

-RPS3chr11

75115767

+
intron-intronENST00000355288ENST00000534440ANK3chr10

62267257

-RPS3chr11

75115767

+
intron-intronENST00000373827ENST00000278572ANK3chr10

62267257

-RPS3chr11

75115767

+
intron-intronENST00000373827ENST00000524851ANK3chr10

62267257

-RPS3chr11

75115767

+
intron-intronENST00000373827ENST00000526608ANK3chr10

62267257

-RPS3chr11

75115767

+
intron-intronENST00000373827ENST00000527446ANK3chr10

62267257

-RPS3chr11

75115767

+
intron-intronENST00000373827ENST00000530164ANK3chr10

62267257

-RPS3chr11

75115767

+
intron-intronENST00000373827ENST00000534440ANK3chr10

62267257

-RPS3chr11

75115767

+
intron-intronENST00000460468ENST00000278572ANK3chr10

62267257

-RPS3chr11

75115767

+
intron-intronENST00000460468ENST00000524851ANK3chr10

62267257

-RPS3chr11

75115767

+
intron-intronENST00000460468ENST00000526608ANK3chr10

62267257

-RPS3chr11

75115767

+
intron-intronENST00000460468ENST00000527446ANK3chr10

62267257

-RPS3chr11

75115767

+
intron-intronENST00000460468ENST00000530164ANK3chr10

62267257

-RPS3chr11

75115767

+
intron-intronENST00000460468ENST00000534440ANK3chr10

62267257

-RPS3chr11

75115767

+
intron-intronENST00000503366ENST00000278572ANK3chr10

62267257

-RPS3chr11

75115767

+
intron-intronENST00000503366ENST00000524851ANK3chr10

62267257

-RPS3chr11

75115767

+
intron-intronENST00000503366ENST00000526608ANK3chr10

62267257

-RPS3chr11

75115767

+
intron-intronENST00000503366ENST00000527446ANK3chr10

62267257

-RPS3chr11

75115767

+
intron-intronENST00000503366ENST00000530164ANK3chr10

62267257

-RPS3chr11

75115767

+
intron-intronENST00000503366ENST00000534440ANK3chr10

62267257

-RPS3chr11

75115767

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000510382ANK3chr1062267257-ENST00000531188RPS3chr1175115767+2671122619911473172

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000510382ENST00000531188ANK3chr1062267257-RPS3chr1175115767+0.80699430.19300573

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Fusion Genomic Features for ANK3-RPS3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ANK3-RPS3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:62267257/chr11:75115767)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneRPS3chr10:62267257chr11:75115767ENST000002785720721_920279.3333333333333DomainKH type-2
TgeneRPS3chr10:62267257chr11:75115767ENST000005248510621_920244.0DomainKH type-2
TgeneRPS3chr10:62267257chr11:75115767ENST000005274460721_920413.0DomainKH type-2
TgeneRPS3chr10:62267257chr11:75115767ENST000005311880721_920646.6666666666666DomainKH type-2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneANK3chr10:62267257chr11:75115767ENST00000280772-1441519_189805447.666666666667Compositional biasNote=Ser-rich
HgeneANK3chr10:62267257chr11:75115767ENST00000280772-1442247_225005447.666666666667Compositional biasNote=Poly-Thr
HgeneANK3chr10:62267257chr11:75115767ENST00000280772-1442393_239605447.666666666667Compositional biasNote=Poly-Glu
HgeneANK3chr10:62267257chr11:75115767ENST00000280772-1443205_321105447.666666666667Compositional biasNote=Poly-Glu
HgeneANK3chr10:62267257chr11:75115767ENST00000280772-1443255_325905447.666666666667Compositional biasNote=Poly-Pro
HgeneANK3chr10:62267257chr11:75115767ENST00000280772-1443482_348705447.666666666667Compositional biasNote=Poly-Ser
HgeneANK3chr10:62267257chr11:75115767ENST00000280772-1443785_379105447.666666666667Compositional biasNote=Poly-Asn
HgeneANK3chr10:62267257chr11:75115767ENST00000280772-1443957_398105447.666666666667Compositional biasNote=Thr-rich
HgeneANK3chr10:62267257chr11:75115767ENST00000355288-1211519_18980814.0Compositional biasNote=Ser-rich
HgeneANK3chr10:62267257chr11:75115767ENST00000355288-1212247_22500814.0Compositional biasNote=Poly-Thr
HgeneANK3chr10:62267257chr11:75115767ENST00000355288-1212393_23960814.0Compositional biasNote=Poly-Glu
HgeneANK3chr10:62267257chr11:75115767ENST00000355288-1213205_32110814.0Compositional biasNote=Poly-Glu
HgeneANK3chr10:62267257chr11:75115767ENST00000355288-1213255_32590814.0Compositional biasNote=Poly-Pro
HgeneANK3chr10:62267257chr11:75115767ENST00000355288-1213482_34870814.0Compositional biasNote=Poly-Ser
HgeneANK3chr10:62267257chr11:75115767ENST00000355288-1213785_37910814.0Compositional biasNote=Poly-Asn
HgeneANK3chr10:62267257chr11:75115767ENST00000355288-1213957_39810814.0Compositional biasNote=Thr-rich
HgeneANK3chr10:62267257chr11:75115767ENST00000373827-1441519_189802277.6666666666665Compositional biasNote=Ser-rich
HgeneANK3chr10:62267257chr11:75115767ENST00000373827-1442247_225002277.6666666666665Compositional biasNote=Poly-Thr
HgeneANK3chr10:62267257chr11:75115767ENST00000373827-1442393_239602277.6666666666665Compositional biasNote=Poly-Glu
HgeneANK3chr10:62267257chr11:75115767ENST00000373827-1443205_321102277.6666666666665Compositional biasNote=Poly-Glu
HgeneANK3chr10:62267257chr11:75115767ENST00000373827-1443255_325902277.6666666666665Compositional biasNote=Poly-Pro
HgeneANK3chr10:62267257chr11:75115767ENST00000373827-1443482_348702277.6666666666665Compositional biasNote=Poly-Ser
HgeneANK3chr10:62267257chr11:75115767ENST00000373827-1443785_379102277.6666666666665Compositional biasNote=Poly-Asn
HgeneANK3chr10:62267257chr11:75115767ENST00000373827-1443957_398102277.6666666666665Compositional biasNote=Thr-rich
HgeneANK3chr10:62267257chr11:75115767ENST00000503366-1441519_189801808.0Compositional biasNote=Ser-rich
HgeneANK3chr10:62267257chr11:75115767ENST00000503366-1442247_225001808.0Compositional biasNote=Poly-Thr
HgeneANK3chr10:62267257chr11:75115767ENST00000503366-1442393_239601808.0Compositional biasNote=Poly-Glu
HgeneANK3chr10:62267257chr11:75115767ENST00000503366-1443205_321101808.0Compositional biasNote=Poly-Glu
HgeneANK3chr10:62267257chr11:75115767ENST00000503366-1443255_325901808.0Compositional biasNote=Poly-Pro
HgeneANK3chr10:62267257chr11:75115767ENST00000503366-1443482_348701808.0Compositional biasNote=Poly-Ser
HgeneANK3chr10:62267257chr11:75115767ENST00000503366-1443785_379101808.0Compositional biasNote=Poly-Asn
HgeneANK3chr10:62267257chr11:75115767ENST00000503366-1443957_398101808.0Compositional biasNote=Thr-rich
HgeneANK3chr10:62267257chr11:75115767ENST00000280772-1441141_128805447.666666666667DomainZU5 2
HgeneANK3chr10:62267257chr11:75115767ENST00000280772-1444090_417405447.666666666667DomainDeath
HgeneANK3chr10:62267257chr11:75115767ENST00000280772-144984_113905447.666666666667DomainZU5 1
HgeneANK3chr10:62267257chr11:75115767ENST00000355288-1211141_12880814.0DomainZU5 2
HgeneANK3chr10:62267257chr11:75115767ENST00000355288-1214090_41740814.0DomainDeath
HgeneANK3chr10:62267257chr11:75115767ENST00000355288-121984_11390814.0DomainZU5 1
HgeneANK3chr10:62267257chr11:75115767ENST00000373827-1441141_128802277.6666666666665DomainZU5 2
HgeneANK3chr10:62267257chr11:75115767ENST00000373827-1444090_417402277.6666666666665DomainDeath
HgeneANK3chr10:62267257chr11:75115767ENST00000373827-144984_113902277.6666666666665DomainZU5 1
HgeneANK3chr10:62267257chr11:75115767ENST00000503366-1441141_128801808.0DomainZU5 2
HgeneANK3chr10:62267257chr11:75115767ENST00000503366-1444090_417401808.0DomainDeath
HgeneANK3chr10:62267257chr11:75115767ENST00000503366-144984_113901808.0DomainZU5 1
HgeneANK3chr10:62267257chr11:75115767ENST00000280772-1441273_140705447.666666666667RegionUPA domain
HgeneANK3chr10:62267257chr11:75115767ENST00000355288-1211273_14070814.0RegionUPA domain
HgeneANK3chr10:62267257chr11:75115767ENST00000373827-1441273_140702277.6666666666665RegionUPA domain
HgeneANK3chr10:62267257chr11:75115767ENST00000503366-1441273_140701808.0RegionUPA domain
HgeneANK3chr10:62267257chr11:75115767ENST00000280772-144106_13505447.666666666667RepeatNote=ANK 2
HgeneANK3chr10:62267257chr11:75115767ENST00000280772-144139_16805447.666666666667RepeatNote=ANK 3
HgeneANK3chr10:62267257chr11:75115767ENST00000280772-144172_20105447.666666666667RepeatNote=ANK 4
HgeneANK3chr10:62267257chr11:75115767ENST00000280772-144203_23005447.666666666667RepeatNote=ANK 5
HgeneANK3chr10:62267257chr11:75115767ENST00000280772-144234_26305447.666666666667RepeatNote=ANK 6
HgeneANK3chr10:62267257chr11:75115767ENST00000280772-144267_29605447.666666666667RepeatNote=ANK 7
HgeneANK3chr10:62267257chr11:75115767ENST00000280772-144300_32905447.666666666667RepeatNote=ANK 8
HgeneANK3chr10:62267257chr11:75115767ENST00000280772-144333_36205447.666666666667RepeatNote=ANK 9
HgeneANK3chr10:62267257chr11:75115767ENST00000280772-144366_39505447.666666666667RepeatNote=ANK 10
HgeneANK3chr10:62267257chr11:75115767ENST00000280772-144399_42805447.666666666667RepeatNote=ANK 11
HgeneANK3chr10:62267257chr11:75115767ENST00000280772-144432_46105447.666666666667RepeatNote=ANK 12
HgeneANK3chr10:62267257chr11:75115767ENST00000280772-144465_49405447.666666666667RepeatNote=ANK 13
HgeneANK3chr10:62267257chr11:75115767ENST00000280772-144498_52705447.666666666667RepeatNote=ANK 14
HgeneANK3chr10:62267257chr11:75115767ENST00000280772-144531_56005447.666666666667RepeatNote=ANK 15
HgeneANK3chr10:62267257chr11:75115767ENST00000280772-144564_59305447.666666666667RepeatNote=ANK 16
HgeneANK3chr10:62267257chr11:75115767ENST00000280772-144597_62605447.666666666667RepeatNote=ANK 17
HgeneANK3chr10:62267257chr11:75115767ENST00000280772-144630_65905447.666666666667RepeatNote=ANK 18
HgeneANK3chr10:62267257chr11:75115767ENST00000280772-144663_69205447.666666666667RepeatNote=ANK 19
HgeneANK3chr10:62267257chr11:75115767ENST00000280772-144696_72505447.666666666667RepeatNote=ANK 20
HgeneANK3chr10:62267257chr11:75115767ENST00000280772-144729_75805447.666666666667RepeatNote=ANK 21
HgeneANK3chr10:62267257chr11:75115767ENST00000280772-14473_10205447.666666666667RepeatNote=ANK 1
HgeneANK3chr10:62267257chr11:75115767ENST00000280772-144762_79105447.666666666667RepeatNote=ANK 22
HgeneANK3chr10:62267257chr11:75115767ENST00000280772-144795_82505447.666666666667RepeatNote=ANK 23
HgeneANK3chr10:62267257chr11:75115767ENST00000355288-121106_1350814.0RepeatNote=ANK 2
HgeneANK3chr10:62267257chr11:75115767ENST00000355288-121139_1680814.0RepeatNote=ANK 3
HgeneANK3chr10:62267257chr11:75115767ENST00000355288-121172_2010814.0RepeatNote=ANK 4
HgeneANK3chr10:62267257chr11:75115767ENST00000355288-121203_2300814.0RepeatNote=ANK 5
HgeneANK3chr10:62267257chr11:75115767ENST00000355288-121234_2630814.0RepeatNote=ANK 6
HgeneANK3chr10:62267257chr11:75115767ENST00000355288-121267_2960814.0RepeatNote=ANK 7
HgeneANK3chr10:62267257chr11:75115767ENST00000355288-121300_3290814.0RepeatNote=ANK 8
HgeneANK3chr10:62267257chr11:75115767ENST00000355288-121333_3620814.0RepeatNote=ANK 9
HgeneANK3chr10:62267257chr11:75115767ENST00000355288-121366_3950814.0RepeatNote=ANK 10
HgeneANK3chr10:62267257chr11:75115767ENST00000355288-121399_4280814.0RepeatNote=ANK 11
HgeneANK3chr10:62267257chr11:75115767ENST00000355288-121432_4610814.0RepeatNote=ANK 12
HgeneANK3chr10:62267257chr11:75115767ENST00000355288-121465_4940814.0RepeatNote=ANK 13
HgeneANK3chr10:62267257chr11:75115767ENST00000355288-121498_5270814.0RepeatNote=ANK 14
HgeneANK3chr10:62267257chr11:75115767ENST00000355288-121531_5600814.0RepeatNote=ANK 15
HgeneANK3chr10:62267257chr11:75115767ENST00000355288-121564_5930814.0RepeatNote=ANK 16
HgeneANK3chr10:62267257chr11:75115767ENST00000355288-121597_6260814.0RepeatNote=ANK 17
HgeneANK3chr10:62267257chr11:75115767ENST00000355288-121630_6590814.0RepeatNote=ANK 18
HgeneANK3chr10:62267257chr11:75115767ENST00000355288-121663_6920814.0RepeatNote=ANK 19
HgeneANK3chr10:62267257chr11:75115767ENST00000355288-121696_7250814.0RepeatNote=ANK 20
HgeneANK3chr10:62267257chr11:75115767ENST00000355288-121729_7580814.0RepeatNote=ANK 21
HgeneANK3chr10:62267257chr11:75115767ENST00000355288-12173_1020814.0RepeatNote=ANK 1
HgeneANK3chr10:62267257chr11:75115767ENST00000355288-121762_7910814.0RepeatNote=ANK 22
HgeneANK3chr10:62267257chr11:75115767ENST00000355288-121795_8250814.0RepeatNote=ANK 23
HgeneANK3chr10:62267257chr11:75115767ENST00000373827-144106_13502277.6666666666665RepeatNote=ANK 2
HgeneANK3chr10:62267257chr11:75115767ENST00000373827-144139_16802277.6666666666665RepeatNote=ANK 3
HgeneANK3chr10:62267257chr11:75115767ENST00000373827-144172_20102277.6666666666665RepeatNote=ANK 4
HgeneANK3chr10:62267257chr11:75115767ENST00000373827-144203_23002277.6666666666665RepeatNote=ANK 5
HgeneANK3chr10:62267257chr11:75115767ENST00000373827-144234_26302277.6666666666665RepeatNote=ANK 6
HgeneANK3chr10:62267257chr11:75115767ENST00000373827-144267_29602277.6666666666665RepeatNote=ANK 7
HgeneANK3chr10:62267257chr11:75115767ENST00000373827-144300_32902277.6666666666665RepeatNote=ANK 8
HgeneANK3chr10:62267257chr11:75115767ENST00000373827-144333_36202277.6666666666665RepeatNote=ANK 9
HgeneANK3chr10:62267257chr11:75115767ENST00000373827-144366_39502277.6666666666665RepeatNote=ANK 10
HgeneANK3chr10:62267257chr11:75115767ENST00000373827-144399_42802277.6666666666665RepeatNote=ANK 11
HgeneANK3chr10:62267257chr11:75115767ENST00000373827-144432_46102277.6666666666665RepeatNote=ANK 12
HgeneANK3chr10:62267257chr11:75115767ENST00000373827-144465_49402277.6666666666665RepeatNote=ANK 13
HgeneANK3chr10:62267257chr11:75115767ENST00000373827-144498_52702277.6666666666665RepeatNote=ANK 14
HgeneANK3chr10:62267257chr11:75115767ENST00000373827-144531_56002277.6666666666665RepeatNote=ANK 15
HgeneANK3chr10:62267257chr11:75115767ENST00000373827-144564_59302277.6666666666665RepeatNote=ANK 16
HgeneANK3chr10:62267257chr11:75115767ENST00000373827-144597_62602277.6666666666665RepeatNote=ANK 17
HgeneANK3chr10:62267257chr11:75115767ENST00000373827-144630_65902277.6666666666665RepeatNote=ANK 18
HgeneANK3chr10:62267257chr11:75115767ENST00000373827-144663_69202277.6666666666665RepeatNote=ANK 19
HgeneANK3chr10:62267257chr11:75115767ENST00000373827-144696_72502277.6666666666665RepeatNote=ANK 20
HgeneANK3chr10:62267257chr11:75115767ENST00000373827-144729_75802277.6666666666665RepeatNote=ANK 21
HgeneANK3chr10:62267257chr11:75115767ENST00000373827-14473_10202277.6666666666665RepeatNote=ANK 1
HgeneANK3chr10:62267257chr11:75115767ENST00000373827-144762_79102277.6666666666665RepeatNote=ANK 22
HgeneANK3chr10:62267257chr11:75115767ENST00000373827-144795_82502277.6666666666665RepeatNote=ANK 23
HgeneANK3chr10:62267257chr11:75115767ENST00000503366-144106_13501808.0RepeatNote=ANK 2
HgeneANK3chr10:62267257chr11:75115767ENST00000503366-144139_16801808.0RepeatNote=ANK 3
HgeneANK3chr10:62267257chr11:75115767ENST00000503366-144172_20101808.0RepeatNote=ANK 4
HgeneANK3chr10:62267257chr11:75115767ENST00000503366-144203_23001808.0RepeatNote=ANK 5
HgeneANK3chr10:62267257chr11:75115767ENST00000503366-144234_26301808.0RepeatNote=ANK 6
HgeneANK3chr10:62267257chr11:75115767ENST00000503366-144267_29601808.0RepeatNote=ANK 7
HgeneANK3chr10:62267257chr11:75115767ENST00000503366-144300_32901808.0RepeatNote=ANK 8
HgeneANK3chr10:62267257chr11:75115767ENST00000503366-144333_36201808.0RepeatNote=ANK 9
HgeneANK3chr10:62267257chr11:75115767ENST00000503366-144366_39501808.0RepeatNote=ANK 10
HgeneANK3chr10:62267257chr11:75115767ENST00000503366-144399_42801808.0RepeatNote=ANK 11
HgeneANK3chr10:62267257chr11:75115767ENST00000503366-144432_46101808.0RepeatNote=ANK 12
HgeneANK3chr10:62267257chr11:75115767ENST00000503366-144465_49401808.0RepeatNote=ANK 13
HgeneANK3chr10:62267257chr11:75115767ENST00000503366-144498_52701808.0RepeatNote=ANK 14
HgeneANK3chr10:62267257chr11:75115767ENST00000503366-144531_56001808.0RepeatNote=ANK 15
HgeneANK3chr10:62267257chr11:75115767ENST00000503366-144564_59301808.0RepeatNote=ANK 16
HgeneANK3chr10:62267257chr11:75115767ENST00000503366-144597_62601808.0RepeatNote=ANK 17
HgeneANK3chr10:62267257chr11:75115767ENST00000503366-144630_65901808.0RepeatNote=ANK 18
HgeneANK3chr10:62267257chr11:75115767ENST00000503366-144663_69201808.0RepeatNote=ANK 19
HgeneANK3chr10:62267257chr11:75115767ENST00000503366-144696_72501808.0RepeatNote=ANK 20
HgeneANK3chr10:62267257chr11:75115767ENST00000503366-144729_75801808.0RepeatNote=ANK 21
HgeneANK3chr10:62267257chr11:75115767ENST00000503366-14473_10201808.0RepeatNote=ANK 1
HgeneANK3chr10:62267257chr11:75115767ENST00000503366-144762_79101808.0RepeatNote=ANK 22
HgeneANK3chr10:62267257chr11:75115767ENST00000503366-144795_82501808.0RepeatNote=ANK 23


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Fusion Gene Sequence for ANK3-RPS3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>4383_4383_1_ANK3-RPS3_ANK3_chr10_62267257_ENST00000510382_RPS3_chr11_75115767_ENST00000531188_length(transcript)=2671nt_BP=1226nt
ACAACATGGCCTCCTCCGCCTCCTCCTCTCCCGCGGGCACCGAGGACTCCGCTCCTGCCCAGGGTGGCTTTGGATCAGATTATTCACGAA
GCTCTAGAAAGGTAAGTGAACTTGGCATTGGCCATTGCTTATTATGCTTCCTGTCTGGCTCTTACTCATGTTGCCATTTTGTGGACTAAA
ACTCAAGGCAGTTCAAAAATACTGATATGCAGGTGCCATGGATGCTGTTGGAGTGTGTGTCCTAAGAGAGAGGGTAAGTGCTGGTTTTCC
ATTTTAAACATAGCTCGTGATATCAAGTTGCCCCCTCCCTTCATTCCCTGACTCCCGTCTTCCTCCAAAAGCGGCTCTCTTGGTTTAGTA
AGCATCTCTACCCTGCAAAGCGGAAATAATGAAAAATGAGATTCACTTTGCAAGCTTGTTGGGTGAGCTTCTGGAGAATAATTTTTACCA
AAAGCCTGAAATCATTTGGCATTGTTGGTGTTTTCAATGCATCTGCATCACAGCACATTGCATTTCACATCTGGCCAGTTTGGAATGAAA
CTTAGAAAATCACCAGACTATAGTGATGTAATTGTCATGAAGTGGTTTTTGTAGCTTAGAGAAAAGAAAAACACTTGGCTGAAAGAATGG
TCTGAAGTCCCACCCAAAGTAAAACATTCTAAATTAATAGTTGCCTAAAGACTACAGTATTATTAGACTTCTATTTAAAAAAATTCACAG
TTCTAATCAAAGAAGTGTAATTGGAGTTTCCTTTTTAAATATTTGAAGACTGTATTTACTATTTTGATGTTCAAATATTAGATCTATATT
TAGAAGGAAGTCCAGAGGCATTTTAAGCTAAATAGGAATGTGGATTCCTATTCAACTTACTATTGGAAAAATACATTGTCATTATAGACT
TTTTAAAGTATTAAGTAGCTTTTAAAAAACATTATAGGACTGTTATAGCTAAATCCTTTTAATATCTTCATTACTCTTAATTCTCTAGGA
GTTTAGTAACATTTTGCTTTTTTTGGTAAAATTTGAAGTCTAATTTACTAGTTGGCTATTTCTTTACATTGAGAATGGTTATTACTTTTT
CACTCTGAACAATTGAAAATTAAGAAAAATTACACTTAAATATAAATTCTTGATGGTTTTCTTTGCTGTTCTTTTCATTTATTATTGGAA
AACAGATACTGCATTAAAGTATTTGTTGAAATATGCCTAAGTGTGTTTTCAGATTGGATTGGCCCTAAGAAGCCCCTGCCTGACCACGTG
AGCATTGTGGAACCCAAAGATGAGATACTGCCCACCACCCCCATCTCAGAACAGAAGGGTGGGAAGCCAGAGCCGCCTGCCATGCCCCAG
CCAGTCCCCACAGCATAACAGGGTCTCCTTGGCAGCTGTATTCTGGAGTCTGGATGTTGCTCTCTAAAGACCTTTAATAAAATTTTGTAC
AAAGACACAAGGTCTGACTAGACTGTTCAGTATTCAGACTGAGGGGCATGTTGGCCTCTGGAGCATTACATATCTTCTTGGTTTTAACCA
TACTTGTGGTATTTGCAAGGGCCAGAACAGTAAGACCCAAGCAGAGCCAACCAGAGAAATAATATTTGTGTGATAGAGAAGGCTGATAGC
AAGCAAGGCAGCACCTTGATTCGTTGTCCTGTAGTTCAGGATTGTAGGTTTAGAAGAGGGATATGTTTGAGTTTTTCCTATGCATAAGGC
GATCCACGTTGCACATAGAAAGTGAATATAAATGGCCATTATATTTTGTGTCATGCTGTGCTCTAAGTGTTCTTTACATATGTACTCGTT
AATCAACCTCTCTAAAGTGTAAAGGAAATTTGCTTGCACCACTGAAGGCACATAAGGCTCAGAAGTAAATTTGCCTAAGCAGTATAAAGC
TATCATTAGAATCCACATTCCTAAGTTGTGTTCTCTTAGGGGATCATGGAACCAGTCATTGGTACTACAGGCTATTATGTTCTGGAGAAC
TGTGAAGAACATTTAAATTGTCTCTGATTTTATCTATCAATGTTTTGAAGTATTTTCTACCAGTGTCTGTACTTCACAAGAAATTCGGCA
CTATTTTTTCAGGCAAAACTAGTGAGGGACAGGTTGGCTTGAAAATCATGAGACTGTTGTTAAATCAGATGCTGGTTGATCACAGAGGGG
ACTTCCAGGGAAAGCTGTTATCAGGTGGCTGCTTCCTGGTGATGCAGCCTGGCTGATGAGATAACCCTGGCTCCACAGATGGCTTAGCAG
GTGCTGTGATGATTTGGTTTTCTTCTCAATTAGACTGAGCTGCACATGGTGTTTATATTGCTTGGCACATGGTAAGGGCTTAATATTTGA
GGTAATTATGTAGGGCGTACACTGACAAGTATCTGACCCCCCCTTCCTTTTTGACTCATAAATTGGTCATCTTAACCATTTAAGTGTACA
CTTCTATAGTGACAGAGTTAGCCCTCTGTCCAAGGGATTTGCATCTGTGGATTCAACCAACTTTGGGTCAAAAATAATCAAAAAGGATGG
TTGTGTGTGTATTGAACATGTAGACTTATTTTTCTTATTTTCAAAATACTATATTTTCTTGTCACTTATTTTCTTGTACACTGCAGTTGT

>4383_4383_1_ANK3-RPS3_ANK3_chr10_62267257_ENST00000510382_RPS3_chr11_75115767_ENST00000531188_length(amino acids)=172AA_BP=
MFFTVLQNIIACSTNDWFHDPLREHNLGMWILMIALYCLGKFTSEPYVPSVVQANFLYTLERLINEYICKEHLEHSMTQNIMAIYIHFLC

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ANK3-RPS3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ANK3-RPS3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ANK3-RPS3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource