|
||||||
|
 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:LAMA5-RNF114 (FusionGDB2 ID:43916) |
Fusion Gene Summary for LAMA5-RNF114 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: LAMA5-RNF114 | Fusion gene ID: 43916 | Hgene | Tgene | Gene symbol | LAMA5 | RNF114 | Gene ID | 3911 | 55905 |
| Gene name | laminin subunit alpha 5 | ring finger protein 114 | |
| Synonyms | - | PSORS12|ZNF313 | |
| Cytomap | 20q13.33 | 20q13.13 | |
| Type of gene | protein-coding | protein-coding | |
| Description | laminin subunit alpha-5laminin alpha-5 chainlaminin-10 subunit alphalaminin-11 subunit alphalaminin-15 subunit alpha | E3 ubiquitin-protein ligase RNF114RING-type E3 ubiquitin transferase RNF114zinc finger protein 228zinc finger protein 313 | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | O15230 | . | |
| Ensembl transtripts involved in fusion gene | ENST00000252999, ENST00000370677, ENST00000370692, ENST00000492698, | ENST00000244061, | |
| Fusion gene scores | * DoF score | 20 X 20 X 14=5600 | 9 X 9 X 5=405 |
| # samples | 28 | 10 | |
| ** MAII score | log2(28/5600*10)=-4.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(10/405*10)=-2.01792190799726 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: LAMA5 [Title/Abstract] AND RNF114 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | LAMA5(60937456)-RNF114(48558098), # samples:2 | ||
| Anticipated loss of major functional domain due to fusion event. | LAMA5-RNF114 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | LAMA5 | GO:0016477 | cell migration | 11821406 |
| Hgene | LAMA5 | GO:0034446 | substrate adhesion-dependent cell spreading | 16236823 |
| Fusion gene breakpoints across LAMA5 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
 |
| Fusion gene breakpoints across RNF114 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
 |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | COAD | TCGA-A6-5660-01A | LAMA5 | chr20 | 60937456 | - | RNF114 | chr20 | 48558098 | + |
| ChimerDB4 | COAD | TCGA-A6-5660-01A | LAMA5 | chr20 | 60937456 | - | RNF114 | chr20 | 48561919 | + |
Top |
Fusion Gene ORF analysis for LAMA5-RNF114 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000252999 | ENST00000244061 | LAMA5 | chr20 | 60937456 | - | RNF114 | chr20 | 48558098 | + |
| Frame-shift | ENST00000370677 | ENST00000244061 | LAMA5 | chr20 | 60937456 | - | RNF114 | chr20 | 48558098 | + |
| Frame-shift | ENST00000370692 | ENST00000244061 | LAMA5 | chr20 | 60937456 | - | RNF114 | chr20 | 48558098 | + |
| In-frame | ENST00000252999 | ENST00000244061 | LAMA5 | chr20 | 60937456 | - | RNF114 | chr20 | 48561919 | + |
| In-frame | ENST00000370677 | ENST00000244061 | LAMA5 | chr20 | 60937456 | - | RNF114 | chr20 | 48561919 | + |
| In-frame | ENST00000370692 | ENST00000244061 | LAMA5 | chr20 | 60937456 | - | RNF114 | chr20 | 48561919 | + |
| intron-3CDS | ENST00000492698 | ENST00000244061 | LAMA5 | chr20 | 60937456 | - | RNF114 | chr20 | 48558098 | + |
| intron-3CDS | ENST00000492698 | ENST00000244061 | LAMA5 | chr20 | 60937456 | - | RNF114 | chr20 | 48561919 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000252999 | LAMA5 | chr20 | 60937456 | - | ENST00000244061 | RNF114 | chr20 | 48561919 | + | 2664 | 517 | 67 | 912 | 281 |
| ENST00000370692 | LAMA5 | chr20 | 60937456 | - | ENST00000244061 | RNF114 | chr20 | 48561919 | + | 2649 | 502 | 52 | 897 | 281 |
| ENST00000370677 | LAMA5 | chr20 | 60937456 | - | ENST00000244061 | RNF114 | chr20 | 48561919 | + | 2622 | 475 | 25 | 870 | 281 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000252999 | ENST00000244061 | LAMA5 | chr20 | 60937456 | - | RNF114 | chr20 | 48561919 | + | 0.000559793 | 0.99944013 |
| ENST00000370692 | ENST00000244061 | LAMA5 | chr20 | 60937456 | - | RNF114 | chr20 | 48561919 | + | 0.000565324 | 0.99943465 |
| ENST00000370677 | ENST00000244061 | LAMA5 | chr20 | 60937456 | - | RNF114 | chr20 | 48561919 | + | 0.0005896 | 0.9994104 |
Top |
Fusion Genomic Features for LAMA5-RNF114 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| LAMA5 | chr20 | 60937455 | - | RNF114 | chr20 | 48558097 | + | 9.89E-06 | 0.9999901 |
| LAMA5 | chr20 | 60937455 | - | RNF114 | chr20 | 48561918 | + | 7.04E-08 | 0.9999999 |
| LAMA5 | chr20 | 60937455 | - | RNF114 | chr20 | 48558097 | + | 9.89E-06 | 0.9999901 |
| LAMA5 | chr20 | 60937455 | - | RNF114 | chr20 | 48561918 | + | 7.04E-08 | 0.9999999 |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
 |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
 |
Top |
Fusion Protein Features for LAMA5-RNF114 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr20:60937456/chr20:48558098) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| LAMA5 | . |
| FUNCTION: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | LAMA5 | chr20:60937456 | chr20:48561919 | ENST00000252999 | - | 2 | 80 | 2203_2221 | 150 | 3696.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | LAMA5 | chr20:60937456 | chr20:48561919 | ENST00000252999 | - | 2 | 80 | 2335_2466 | 150 | 3696.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | LAMA5 | chr20:60937456 | chr20:48561919 | ENST00000252999 | - | 2 | 80 | 2510_2670 | 150 | 3696.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | LAMA5 | chr20:60937456 | chr20:48561919 | ENST00000252999 | - | 2 | 80 | 1438_1483 | 150 | 3696.0 | Domain | Laminin EGF-like 12 |
| Hgene | LAMA5 | chr20:60937456 | chr20:48561919 | ENST00000252999 | - | 2 | 80 | 1484_1527 | 150 | 3696.0 | Domain | Laminin EGF-like 13 |
| Hgene | LAMA5 | chr20:60937456 | chr20:48561919 | ENST00000252999 | - | 2 | 80 | 1528_1576 | 150 | 3696.0 | Domain | Laminin EGF-like 14 |
| Hgene | LAMA5 | chr20:60937456 | chr20:48561919 | ENST00000252999 | - | 2 | 80 | 1577_1627 | 150 | 3696.0 | Domain | Laminin EGF-like 15 |
| Hgene | LAMA5 | chr20:60937456 | chr20:48561919 | ENST00000252999 | - | 2 | 80 | 1628_1637 | 150 | 3696.0 | Domain | Laminin EGF-like 16%3B first part |
| Hgene | LAMA5 | chr20:60937456 | chr20:48561919 | ENST00000252999 | - | 2 | 80 | 1641_1830 | 150 | 3696.0 | Domain | Laminin IV type A |
| Hgene | LAMA5 | chr20:60937456 | chr20:48561919 | ENST00000252999 | - | 2 | 80 | 1831_1863 | 150 | 3696.0 | Domain | Laminin EGF-like 16%3B second part |
| Hgene | LAMA5 | chr20:60937456 | chr20:48561919 | ENST00000252999 | - | 2 | 80 | 1864_1912 | 150 | 3696.0 | Domain | Laminin EGF-like 17 |
| Hgene | LAMA5 | chr20:60937456 | chr20:48561919 | ENST00000252999 | - | 2 | 80 | 1913_1968 | 150 | 3696.0 | Domain | Laminin EGF-like 18 |
| Hgene | LAMA5 | chr20:60937456 | chr20:48561919 | ENST00000252999 | - | 2 | 80 | 1969_2022 | 150 | 3696.0 | Domain | Laminin EGF-like 19 |
| Hgene | LAMA5 | chr20:60937456 | chr20:48561919 | ENST00000252999 | - | 2 | 80 | 2023_2069 | 150 | 3696.0 | Domain | Laminin EGF-like 20 |
| Hgene | LAMA5 | chr20:60937456 | chr20:48561919 | ENST00000252999 | - | 2 | 80 | 2070_2116 | 150 | 3696.0 | Domain | Laminin EGF-like 21 |
| Hgene | LAMA5 | chr20:60937456 | chr20:48561919 | ENST00000252999 | - | 2 | 80 | 2117_2166 | 150 | 3696.0 | Domain | Laminin EGF-like 22 |
| Hgene | LAMA5 | chr20:60937456 | chr20:48561919 | ENST00000252999 | - | 2 | 80 | 2736_2929 | 150 | 3696.0 | Domain | Laminin G-like 1 |
| Hgene | LAMA5 | chr20:60937456 | chr20:48561919 | ENST00000252999 | - | 2 | 80 | 2941_3115 | 150 | 3696.0 | Domain | Laminin G-like 2 |
| Hgene | LAMA5 | chr20:60937456 | chr20:48561919 | ENST00000252999 | - | 2 | 80 | 300_358 | 150 | 3696.0 | Domain | Laminin EGF-like 1 |
| Hgene | LAMA5 | chr20:60937456 | chr20:48561919 | ENST00000252999 | - | 2 | 80 | 3124_3292 | 150 | 3696.0 | Domain | Laminin G-like 3 |
| Hgene | LAMA5 | chr20:60937456 | chr20:48561919 | ENST00000252999 | - | 2 | 80 | 3340_3513 | 150 | 3696.0 | Domain | Laminin G-like 4 |
| Hgene | LAMA5 | chr20:60937456 | chr20:48561919 | ENST00000252999 | - | 2 | 80 | 3520_3692 | 150 | 3696.0 | Domain | Laminin G-like 5 |
| Hgene | LAMA5 | chr20:60937456 | chr20:48561919 | ENST00000252999 | - | 2 | 80 | 359_428 | 150 | 3696.0 | Domain | Laminin EGF-like 2 |
| Hgene | LAMA5 | chr20:60937456 | chr20:48561919 | ENST00000252999 | - | 2 | 80 | 41_299 | 150 | 3696.0 | Domain | Laminin N-terminal |
| Hgene | LAMA5 | chr20:60937456 | chr20:48561919 | ENST00000252999 | - | 2 | 80 | 429_474 | 150 | 3696.0 | Domain | Laminin EGF-like 3 |
| Hgene | LAMA5 | chr20:60937456 | chr20:48561919 | ENST00000252999 | - | 2 | 80 | 494_540 | 150 | 3696.0 | Domain | Laminin EGF-like 4 |
| Hgene | LAMA5 | chr20:60937456 | chr20:48561919 | ENST00000252999 | - | 2 | 80 | 541_586 | 150 | 3696.0 | Domain | Laminin EGF-like 5 |
| Hgene | LAMA5 | chr20:60937456 | chr20:48561919 | ENST00000252999 | - | 2 | 80 | 587_631 | 150 | 3696.0 | Domain | Laminin EGF-like 6 |
| Hgene | LAMA5 | chr20:60937456 | chr20:48561919 | ENST00000252999 | - | 2 | 80 | 632_676 | 150 | 3696.0 | Domain | Laminin EGF-like 7 |
| Hgene | LAMA5 | chr20:60937456 | chr20:48561919 | ENST00000252999 | - | 2 | 80 | 677_722 | 150 | 3696.0 | Domain | Laminin EGF-like 8 |
| Hgene | LAMA5 | chr20:60937456 | chr20:48561919 | ENST00000252999 | - | 2 | 80 | 723_775 | 150 | 3696.0 | Domain | Laminin EGF-like 9 |
| Hgene | LAMA5 | chr20:60937456 | chr20:48561919 | ENST00000252999 | - | 2 | 80 | 776_828 | 150 | 3696.0 | Domain | Laminin EGF-like 10 |
| Hgene | LAMA5 | chr20:60937456 | chr20:48561919 | ENST00000252999 | - | 2 | 80 | 829_850 | 150 | 3696.0 | Domain | Laminin EGF-like 11%3B truncated |
| Hgene | LAMA5 | chr20:60937456 | chr20:48561919 | ENST00000252999 | - | 2 | 80 | 1722_1724 | 150 | 3696.0 | Motif | Cell attachment site |
| Hgene | LAMA5 | chr20:60937456 | chr20:48561919 | ENST00000252999 | - | 2 | 80 | 1838_1840 | 150 | 3696.0 | Motif | Cell attachment site |
| Hgene | LAMA5 | chr20:60937456 | chr20:48561919 | ENST00000252999 | - | 2 | 80 | 2167_2735 | 150 | 3696.0 | Region | Note=Domain II and I |
| Hgene | LAMA5 | chr20:60937456 | chr20:48561919 | ENST00000252999 | - | 2 | 80 | 851_1437 | 150 | 3696.0 | Region | Note=Domain IV 1 (domain IV B) |
| Tgene | RNF114 | chr20:60937456 | chr20:48561919 | ENST00000244061 | 1 | 6 | 29_68 | 97 | 229.0 | Zinc finger | RING-type | |
| Tgene | RNF114 | chr20:60937456 | chr20:48561919 | ENST00000244061 | 1 | 6 | 91_110 | 97 | 229.0 | Zinc finger | C2HC RNF-type |
Top |
Fusion Gene Sequence for LAMA5-RNF114 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >43916_43916_1_LAMA5-RNF114_LAMA5_chr20_60937456_ENST00000252999_RNF114_chr20_48561919_ENST00000244061_length(transcript)=2664nt_BP=517nt AGACCCGCCGGGCTCCCGCCGCGCGCGCTGTCCCTGGAGCTCGGGGACGCGGCCCGGAGCCGGGAAGATGGCGAAGCGGCTCTGCGCGGG GAGCGCACTGTGTGTTCGCGGCCCCCGGGGCCCCGCGCCGCTGCTGCTGGTCGGGCTGGCGCTGCTGGGCGCGGCGCGGGCGCGGGAGGA GGCGGGCGGCGGCTTCAGCCTGCACCCGCCCTACTTCAACCTGGCCGAGGGCGCCCGCATCGCCGCCTCCGCGACCTGCGGAGAGGAGGC CCCGGCGCGCGGCTCCCCGCGCCCCACCGAGGACCTTTACTGCAAGCTGGTAGGGGGCCCCGTGGCCGGCGGCGACCCCAACCAGACCAT CCGGGGCCAGTACTGTGACATCTGCACGGCTGCCAACAGCAACAAGGCACACCCCGCGAGCAATGCCATCGATGGCACGGAGCGCTGGTG GCAGAGTCCACCGCTGTCCCGCGGCCTGGAGTACAACGAGGTCAACGTCACCCTGGACCTGGGCCAGTTCTTCCTGTCCAAGATCCGGTC CCACGTGGCTACTTGTTCCAAATACCAGAATTACATCATGGAAGGTGTGAAGGCCACCATTAAGGATGCATCTCTTCAGCCAAGGAATGT TCCAAACCGTTACACCTTTCCTTGTCCTTACTGTCCTGAGAAGAACTTTGATCAGGAAGGACTTGTGGAACACTGCAAATTATTCCATAG CACGGATACCAAATCTGTGGTTTGTCCGATATGTGCCTCGATGCCCTGGGGAGACCCCAACTACCGCAGCGCCAACTTCAGAGAGCACAT CCAGCGCCGGCACCGGTTTTCTTATGACACTTTTGTGGATTATGATGTTGATGAAGAGGACATGATGAATCAGGTGTTGCAGCGCTCCAT CATCGACCAGTGAGCAGAGTCCGTGCTTGCTATCTGTCTCATGTTACAGAGCTTCCATTACATATTAAACGTGAAATCTATGACTCCTGT ACCTTACCTGTTCAACAGACCTGAAAATGAGCCATGGCATTGGGACAGGGTCACTTCTGACAGGGGAAGTGGGTCCCCAGGTCAGCCCTT CTCTTCCCTTTGGGCTCTTGCCAAAGCTGTCTTCCCCTACTGTTAACCTTGTTTGTCACACGGTCGAGTTCGTATTGGTTCTCGGCTACT TCCTGGAGCTTCTGCCGCCTCCTGTGGAAGATAATCTAGCTTCTCCACCTCTTGTTTCACACTCATTCCTCCCATCCAGTGTTTGTCTCT CGGGTCCTTCAAGCCAGCCAGGACCTTTTCTGGGTCATGAATAGCACAATGAAGCAAGTGTCTCCTTTCCTTGTCCCCAAGGTGTGCAGA CTTTGGCAGCCGTGCACCTGACCAGAGCTGAAGCTCCCGCTGGGCTGTGGGGTTGCCAGAAGCTGGGGTTGCCATCCCGGGGTACATGTC ACCAGTCCTCTTGGGGTTTTGTACCATCTGATGCTGGAAGTTTTGATTAGTGATATTTTCTACTACTACATATTTAGAGTTCACTGGTTC AGTCTTAAATGCCTGCATGGTGCCTTTTTAGGATAAGGTATAACCATACATTTTTGGTGGAAGTGTTTCTGGGTTAGGGAAGTTAAAGTC TGTTTATCCGTAAGTGGGGAGGAGGGTCAGCTAAGAGAAGTGGGAGGGCCAGAGCTTTTTGGTTCTGATTTACAAATTAATGAAGTAGTT TCAAACAACGCGGTCATGTTTACCTCTCCATTTGGGAGCCTGCCTACATTCTTGTTCTAGAAGCACAAAAAATCCTCAGATGAATTAGAA GAAAGAGGTTTGGGGACTCAGCGGATACTAGTTCTTTTACCTTCTGCTTGGTAACTTAGATTAAACTGAGCATTGTTTTTCTGTCACAAA TGTTTTCCTTATGACACTGGTTTCGACATGTAAAATGTGTTTGAAAACCTGCTTTGTAGATGCAGAGAGAAGCTATAGGAAACCCAGTAC CACCCCTGGTCTGTTCTGACGAGACATCGTTCATAAGGCACAGCACATCGCAAGATGAACAGTTGTTAATAAAAGCTGTTGCTGGAAACT TGCTTTAGGAACAGCTCAAGAACCTTGGAGTTCATATTTCACAAATATTAATAAATATAAGTCCAAGAGCTGTCAGCCTAATCTGTAGGA GCAGAACCTCTGATTGACCAAAAGGCATATGGGTTTAGGTTGGTTTTTTGATGTCATATGTCTCTGATGGGGCTGCAAGTGCTACCTCGC GCTTGTACACTGCTGCTGTGGGGCTCCGCGCCTGCCGGTGAAGAGCTGCAGATGCCGAGAAGCCAGCAAACACAGGGCCCACTGGAAAAA AATAGTTTTTTCATTAGTATTTCTCGGGAGGACCCAAAAGTTAAGGTCAGCTTGTTCACTGTAATTTCTGGAAGAAGTTCACTCAGACCT TCCTGAATTCAGATCATCTCAGAAGTCTGGAGGGAAATCTGGCGAAACCTTCGTTTGAGGGACTGATGTGAGTGTATGTCCACCTCACTG GTGGCACCGAGAAACTTACTTCCTTGTATTAAGTGCACTTCTTGTATTTCTAATAAGATGACTTTCCAGAAAGTGAGATTTGTTATGTTC >43916_43916_1_LAMA5-RNF114_LAMA5_chr20_60937456_ENST00000252999_RNF114_chr20_48561919_ENST00000244061_length(amino acids)=281AA_BP=150 MAKRLCAGSALCVRGPRGPAPLLLVGLALLGAARAREEAGGGFSLHPPYFNLAEGARIAASATCGEEAPARGSPRPTEDLYCKLVGGPVA GGDPNQTIRGQYCDICTAANSNKAHPASNAIDGTERWWQSPPLSRGLEYNEVNVTLDLGQFFLSKIRSHVATCSKYQNYIMEGVKATIKD ASLQPRNVPNRYTFPCPYCPEKNFDQEGLVEHCKLFHSTDTKSVVCPICASMPWGDPNYRSANFREHIQRRHRFSYDTFVDYDVDEEDMM -------------------------------------------------------------- >43916_43916_2_LAMA5-RNF114_LAMA5_chr20_60937456_ENST00000370677_RNF114_chr20_48561919_ENST00000244061_length(transcript)=2622nt_BP=475nt GGGGACGCGGCCCGGAGCCGGGAAGATGGCGAAGCGGCTCTGCGCGGGGAGCGCACTGTGTGTTCGCGGCCCCCGGGGCCCCGCGCCGCT GCTGCTGGTCGGGCTGGCGCTGCTGGGCGCGGCGCGGGCGCGGGAGGAGGCGGGCGGCGGCTTCAGCCTGCACCCGCCCTACTTCAACCT GGCCGAGGGCGCCCGCATCGCCGCCTCCGCGACCTGCGGAGAGGAGGCCCCGGCGCGCGGCTCCCCGCGCCCCACCGAGGACCTTTACTG CAAGCTGGTAGGGGGCCCCGTGGCCGGCGGCGACCCCAACCAGACCATCCGGGGCCAGTACTGTGACATCTGCACGGCTGCCAACAGCAA CAAGGCACACCCCGCGAGCAATGCCATCGATGGCACGGAGCGCTGGTGGCAGAGTCCACCGCTGTCCCGCGGCCTGGAGTACAACGAGGT CAACGTCACCCTGGACCTGGGCCAGTTCTTCCTGTCCAAGATCCGGTCCCACGTGGCTACTTGTTCCAAATACCAGAATTACATCATGGA AGGTGTGAAGGCCACCATTAAGGATGCATCTCTTCAGCCAAGGAATGTTCCAAACCGTTACACCTTTCCTTGTCCTTACTGTCCTGAGAA GAACTTTGATCAGGAAGGACTTGTGGAACACTGCAAATTATTCCATAGCACGGATACCAAATCTGTGGTTTGTCCGATATGTGCCTCGAT GCCCTGGGGAGACCCCAACTACCGCAGCGCCAACTTCAGAGAGCACATCCAGCGCCGGCACCGGTTTTCTTATGACACTTTTGTGGATTA TGATGTTGATGAAGAGGACATGATGAATCAGGTGTTGCAGCGCTCCATCATCGACCAGTGAGCAGAGTCCGTGCTTGCTATCTGTCTCAT GTTACAGAGCTTCCATTACATATTAAACGTGAAATCTATGACTCCTGTACCTTACCTGTTCAACAGACCTGAAAATGAGCCATGGCATTG GGACAGGGTCACTTCTGACAGGGGAAGTGGGTCCCCAGGTCAGCCCTTCTCTTCCCTTTGGGCTCTTGCCAAAGCTGTCTTCCCCTACTG TTAACCTTGTTTGTCACACGGTCGAGTTCGTATTGGTTCTCGGCTACTTCCTGGAGCTTCTGCCGCCTCCTGTGGAAGATAATCTAGCTT CTCCACCTCTTGTTTCACACTCATTCCTCCCATCCAGTGTTTGTCTCTCGGGTCCTTCAAGCCAGCCAGGACCTTTTCTGGGTCATGAAT AGCACAATGAAGCAAGTGTCTCCTTTCCTTGTCCCCAAGGTGTGCAGACTTTGGCAGCCGTGCACCTGACCAGAGCTGAAGCTCCCGCTG GGCTGTGGGGTTGCCAGAAGCTGGGGTTGCCATCCCGGGGTACATGTCACCAGTCCTCTTGGGGTTTTGTACCATCTGATGCTGGAAGTT TTGATTAGTGATATTTTCTACTACTACATATTTAGAGTTCACTGGTTCAGTCTTAAATGCCTGCATGGTGCCTTTTTAGGATAAGGTATA ACCATACATTTTTGGTGGAAGTGTTTCTGGGTTAGGGAAGTTAAAGTCTGTTTATCCGTAAGTGGGGAGGAGGGTCAGCTAAGAGAAGTG GGAGGGCCAGAGCTTTTTGGTTCTGATTTACAAATTAATGAAGTAGTTTCAAACAACGCGGTCATGTTTACCTCTCCATTTGGGAGCCTG CCTACATTCTTGTTCTAGAAGCACAAAAAATCCTCAGATGAATTAGAAGAAAGAGGTTTGGGGACTCAGCGGATACTAGTTCTTTTACCT TCTGCTTGGTAACTTAGATTAAACTGAGCATTGTTTTTCTGTCACAAATGTTTTCCTTATGACACTGGTTTCGACATGTAAAATGTGTTT GAAAACCTGCTTTGTAGATGCAGAGAGAAGCTATAGGAAACCCAGTACCACCCCTGGTCTGTTCTGACGAGACATCGTTCATAAGGCACA GCACATCGCAAGATGAACAGTTGTTAATAAAAGCTGTTGCTGGAAACTTGCTTTAGGAACAGCTCAAGAACCTTGGAGTTCATATTTCAC AAATATTAATAAATATAAGTCCAAGAGCTGTCAGCCTAATCTGTAGGAGCAGAACCTCTGATTGACCAAAAGGCATATGGGTTTAGGTTG GTTTTTTGATGTCATATGTCTCTGATGGGGCTGCAAGTGCTACCTCGCGCTTGTACACTGCTGCTGTGGGGCTCCGCGCCTGCCGGTGAA GAGCTGCAGATGCCGAGAAGCCAGCAAACACAGGGCCCACTGGAAAAAAATAGTTTTTTCATTAGTATTTCTCGGGAGGACCCAAAAGTT AAGGTCAGCTTGTTCACTGTAATTTCTGGAAGAAGTTCACTCAGACCTTCCTGAATTCAGATCATCTCAGAAGTCTGGAGGGAAATCTGG CGAAACCTTCGTTTGAGGGACTGATGTGAGTGTATGTCCACCTCACTGGTGGCACCGAGAAACTTACTTCCTTGTATTAAGTGCACTTCT TGTATTTCTAATAAGATGACTTTCCAGAAAGTGAGATTTGTTATGTTCTGGCTTTTAAAAGGTAAAATATAAATAAATTTCATAACTTAA >43916_43916_2_LAMA5-RNF114_LAMA5_chr20_60937456_ENST00000370677_RNF114_chr20_48561919_ENST00000244061_length(amino acids)=281AA_BP=150 MAKRLCAGSALCVRGPRGPAPLLLVGLALLGAARAREEAGGGFSLHPPYFNLAEGARIAASATCGEEAPARGSPRPTEDLYCKLVGGPVA GGDPNQTIRGQYCDICTAANSNKAHPASNAIDGTERWWQSPPLSRGLEYNEVNVTLDLGQFFLSKIRSHVATCSKYQNYIMEGVKATIKD ASLQPRNVPNRYTFPCPYCPEKNFDQEGLVEHCKLFHSTDTKSVVCPICASMPWGDPNYRSANFREHIQRRHRFSYDTFVDYDVDEEDMM -------------------------------------------------------------- >43916_43916_3_LAMA5-RNF114_LAMA5_chr20_60937456_ENST00000370692_RNF114_chr20_48561919_ENST00000244061_length(transcript)=2649nt_BP=502nt CCGCCGCGCGCGCTGTCCCTGGAGCTCGGGGACGCGGCCCGGAGCCGGGAAGATGGCGAAGCGGCTCTGCGCGGGGAGCGCACTGTGTGT TCGCGGCCCCCGGGGCCCCGCGCCGCTGCTGCTGGTCGGGCTGGCGCTGCTGGGCGCGGCGCGGGCGCGGGAGGAGGCGGGCGGCGGCTT CAGCCTGCACCCGCCCTACTTCAACCTGGCCGAGGGCGCCCGCATCGCCGCCTCCGCGACCTGCGGAGAGGAGGCCCCGGCGCGCGGCTC CCCGCGCCCCACCGAGGACCTTTACTGCAAGCTGGTAGGGGGCCCCGTGGCCGGCGGCGACCCCAACCAGACCATCCGGGGCCAGTACTG TGACATCTGCACGGCTGCCAACAGCAACAAGGCACACCCCGCGAGCAATGCCATCGATGGCACGGAGCGCTGGTGGCAGAGTCCACCGCT GTCCCGCGGCCTGGAGTACAACGAGGTCAACGTCACCCTGGACCTGGGCCAGTTCTTCCTGTCCAAGATCCGGTCCCACGTGGCTACTTG TTCCAAATACCAGAATTACATCATGGAAGGTGTGAAGGCCACCATTAAGGATGCATCTCTTCAGCCAAGGAATGTTCCAAACCGTTACAC CTTTCCTTGTCCTTACTGTCCTGAGAAGAACTTTGATCAGGAAGGACTTGTGGAACACTGCAAATTATTCCATAGCACGGATACCAAATC TGTGGTTTGTCCGATATGTGCCTCGATGCCCTGGGGAGACCCCAACTACCGCAGCGCCAACTTCAGAGAGCACATCCAGCGCCGGCACCG GTTTTCTTATGACACTTTTGTGGATTATGATGTTGATGAAGAGGACATGATGAATCAGGTGTTGCAGCGCTCCATCATCGACCAGTGAGC AGAGTCCGTGCTTGCTATCTGTCTCATGTTACAGAGCTTCCATTACATATTAAACGTGAAATCTATGACTCCTGTACCTTACCTGTTCAA CAGACCTGAAAATGAGCCATGGCATTGGGACAGGGTCACTTCTGACAGGGGAAGTGGGTCCCCAGGTCAGCCCTTCTCTTCCCTTTGGGC TCTTGCCAAAGCTGTCTTCCCCTACTGTTAACCTTGTTTGTCACACGGTCGAGTTCGTATTGGTTCTCGGCTACTTCCTGGAGCTTCTGC CGCCTCCTGTGGAAGATAATCTAGCTTCTCCACCTCTTGTTTCACACTCATTCCTCCCATCCAGTGTTTGTCTCTCGGGTCCTTCAAGCC AGCCAGGACCTTTTCTGGGTCATGAATAGCACAATGAAGCAAGTGTCTCCTTTCCTTGTCCCCAAGGTGTGCAGACTTTGGCAGCCGTGC ACCTGACCAGAGCTGAAGCTCCCGCTGGGCTGTGGGGTTGCCAGAAGCTGGGGTTGCCATCCCGGGGTACATGTCACCAGTCCTCTTGGG GTTTTGTACCATCTGATGCTGGAAGTTTTGATTAGTGATATTTTCTACTACTACATATTTAGAGTTCACTGGTTCAGTCTTAAATGCCTG CATGGTGCCTTTTTAGGATAAGGTATAACCATACATTTTTGGTGGAAGTGTTTCTGGGTTAGGGAAGTTAAAGTCTGTTTATCCGTAAGT GGGGAGGAGGGTCAGCTAAGAGAAGTGGGAGGGCCAGAGCTTTTTGGTTCTGATTTACAAATTAATGAAGTAGTTTCAAACAACGCGGTC ATGTTTACCTCTCCATTTGGGAGCCTGCCTACATTCTTGTTCTAGAAGCACAAAAAATCCTCAGATGAATTAGAAGAAAGAGGTTTGGGG ACTCAGCGGATACTAGTTCTTTTACCTTCTGCTTGGTAACTTAGATTAAACTGAGCATTGTTTTTCTGTCACAAATGTTTTCCTTATGAC ACTGGTTTCGACATGTAAAATGTGTTTGAAAACCTGCTTTGTAGATGCAGAGAGAAGCTATAGGAAACCCAGTACCACCCCTGGTCTGTT CTGACGAGACATCGTTCATAAGGCACAGCACATCGCAAGATGAACAGTTGTTAATAAAAGCTGTTGCTGGAAACTTGCTTTAGGAACAGC TCAAGAACCTTGGAGTTCATATTTCACAAATATTAATAAATATAAGTCCAAGAGCTGTCAGCCTAATCTGTAGGAGCAGAACCTCTGATT GACCAAAAGGCATATGGGTTTAGGTTGGTTTTTTGATGTCATATGTCTCTGATGGGGCTGCAAGTGCTACCTCGCGCTTGTACACTGCTG CTGTGGGGCTCCGCGCCTGCCGGTGAAGAGCTGCAGATGCCGAGAAGCCAGCAAACACAGGGCCCACTGGAAAAAAATAGTTTTTTCATT AGTATTTCTCGGGAGGACCCAAAAGTTAAGGTCAGCTTGTTCACTGTAATTTCTGGAAGAAGTTCACTCAGACCTTCCTGAATTCAGATC ATCTCAGAAGTCTGGAGGGAAATCTGGCGAAACCTTCGTTTGAGGGACTGATGTGAGTGTATGTCCACCTCACTGGTGGCACCGAGAAAC TTACTTCCTTGTATTAAGTGCACTTCTTGTATTTCTAATAAGATGACTTTCCAGAAAGTGAGATTTGTTATGTTCTGGCTTTTAAAAGGT >43916_43916_3_LAMA5-RNF114_LAMA5_chr20_60937456_ENST00000370692_RNF114_chr20_48561919_ENST00000244061_length(amino acids)=281AA_BP=150 MAKRLCAGSALCVRGPRGPAPLLLVGLALLGAARAREEAGGGFSLHPPYFNLAEGARIAASATCGEEAPARGSPRPTEDLYCKLVGGPVA GGDPNQTIRGQYCDICTAANSNKAHPASNAIDGTERWWQSPPLSRGLEYNEVNVTLDLGQFFLSKIRSHVATCSKYQNYIMEGVKATIKD ASLQPRNVPNRYTFPCPYCPEKNFDQEGLVEHCKLFHSTDTKSVVCPICASMPWGDPNYRSANFREHIQRRHRFSYDTFVDYDVDEEDMM -------------------------------------------------------------- |
Top |
Fusion Gene PPI Analysis for LAMA5-RNF114 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
Related Drugs for LAMA5-RNF114 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
Related Diseases for LAMA5-RNF114 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2021-Present -The University of Texas Health Science Center at Houston (UTHealth)
Web File Viewing | Emergency Information |Campus Carry|Site Policies