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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:LAMB1-NRCAM (FusionGDB2 ID:43929)

Fusion Gene Summary for LAMB1-NRCAM

check button Fusion gene summary
Fusion gene informationFusion gene name: LAMB1-NRCAM
Fusion gene ID: 43929
HgeneTgene
Gene symbol

LAMB1

NRCAM

Gene ID

3912

4897

Gene namelaminin subunit beta 1neuronal cell adhesion molecule
SynonymsCLM|LIS5-
Cytomap

7q31.1

7q31.1

Type of geneprotein-codingprotein-coding
Descriptionlaminin subunit beta-1laminin B1 chainlaminin, beta 1neuronal cell adhesion moleculeNgCAM-related cell adhesion moleculeneuronal surface protein Bravo
Modification date2020031320200313
UniProtAcc.

Q92823

Ensembl transtripts involved in fusion geneENST00000222399, ENST00000393560, 
ENST00000393561, ENST00000474380, 
ENST00000522550, ENST00000351718, 
ENST00000379022, ENST00000379024, 
ENST00000379028, ENST00000413765, 
ENST00000425651, 
Fusion gene scores* DoF score11 X 11 X 5=6057 X 5 X 5=175
# samples 137
** MAII scorelog2(13/605*10)=-2.2184235191335
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/175*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: LAMB1 [Title/Abstract] AND NRCAM [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointLAMB1(107626467)-NRCAM(107800937), # samples:3
Anticipated loss of major functional domain due to fusion event.LAMB1-NRCAM seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneLAMB1

GO:0030335

positive regulation of cell migration

16289578

HgeneLAMB1

GO:0031175

neuron projection development

15894315

HgeneLAMB1

GO:0034446

substrate adhesion-dependent cell spreading

16236823

HgeneLAMB1

GO:0042476

odontogenesis

15894315

TgeneNRCAM

GO:0045162

clustering of voltage-gated sodium channels

14602817


check buttonFusion gene breakpoints across LAMB1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across NRCAM (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-X6-A8C6-01ALAMB1chr7

107626467

-NRCAMchr7

107800937

-


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Fusion Gene ORF analysis for LAMB1-NRCAM

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000222399ENST00000522550LAMB1chr7

107626467

-NRCAMchr7

107800937

-
5CDS-intronENST00000393560ENST00000522550LAMB1chr7

107626467

-NRCAMchr7

107800937

-
5CDS-intronENST00000393561ENST00000522550LAMB1chr7

107626467

-NRCAMchr7

107800937

-
Frame-shiftENST00000222399ENST00000351718LAMB1chr7

107626467

-NRCAMchr7

107800937

-
Frame-shiftENST00000222399ENST00000379022LAMB1chr7

107626467

-NRCAMchr7

107800937

-
Frame-shiftENST00000222399ENST00000379024LAMB1chr7

107626467

-NRCAMchr7

107800937

-
Frame-shiftENST00000222399ENST00000379028LAMB1chr7

107626467

-NRCAMchr7

107800937

-
Frame-shiftENST00000222399ENST00000413765LAMB1chr7

107626467

-NRCAMchr7

107800937

-
Frame-shiftENST00000222399ENST00000425651LAMB1chr7

107626467

-NRCAMchr7

107800937

-
Frame-shiftENST00000393560ENST00000351718LAMB1chr7

107626467

-NRCAMchr7

107800937

-
Frame-shiftENST00000393560ENST00000379022LAMB1chr7

107626467

-NRCAMchr7

107800937

-
Frame-shiftENST00000393560ENST00000379024LAMB1chr7

107626467

-NRCAMchr7

107800937

-
Frame-shiftENST00000393560ENST00000379028LAMB1chr7

107626467

-NRCAMchr7

107800937

-
Frame-shiftENST00000393560ENST00000413765LAMB1chr7

107626467

-NRCAMchr7

107800937

-
Frame-shiftENST00000393560ENST00000425651LAMB1chr7

107626467

-NRCAMchr7

107800937

-
In-frameENST00000393561ENST00000351718LAMB1chr7

107626467

-NRCAMchr7

107800937

-
In-frameENST00000393561ENST00000379022LAMB1chr7

107626467

-NRCAMchr7

107800937

-
In-frameENST00000393561ENST00000379024LAMB1chr7

107626467

-NRCAMchr7

107800937

-
In-frameENST00000393561ENST00000379028LAMB1chr7

107626467

-NRCAMchr7

107800937

-
In-frameENST00000393561ENST00000413765LAMB1chr7

107626467

-NRCAMchr7

107800937

-
In-frameENST00000393561ENST00000425651LAMB1chr7

107626467

-NRCAMchr7

107800937

-
intron-3CDSENST00000474380ENST00000351718LAMB1chr7

107626467

-NRCAMchr7

107800937

-
intron-3CDSENST00000474380ENST00000379022LAMB1chr7

107626467

-NRCAMchr7

107800937

-
intron-3CDSENST00000474380ENST00000379024LAMB1chr7

107626467

-NRCAMchr7

107800937

-
intron-3CDSENST00000474380ENST00000379028LAMB1chr7

107626467

-NRCAMchr7

107800937

-
intron-3CDSENST00000474380ENST00000413765LAMB1chr7

107626467

-NRCAMchr7

107800937

-
intron-3CDSENST00000474380ENST00000425651LAMB1chr7

107626467

-NRCAMchr7

107800937

-
intron-intronENST00000474380ENST00000522550LAMB1chr7

107626467

-NRCAMchr7

107800937

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000393561LAMB1chr7107626467-ENST00000379028NRCAMchr7107800937-3655933561381441
ENST00000393561LAMB1chr7107626467-ENST00000413765NRCAMchr7107800937-3655933561381441
ENST00000393561LAMB1chr7107626467-ENST00000351718NRCAMchr7107800937-3630933561381441
ENST00000393561LAMB1chr7107626467-ENST00000379024NRCAMchr7107800937-3175933561381441
ENST00000393561LAMB1chr7107626467-ENST00000379022NRCAMchr7107800937-1178933561177374
ENST00000393561LAMB1chr7107626467-ENST00000425651NRCAMchr7107800937-1382933561381442

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000393561ENST00000379028LAMB1chr7107626467-NRCAMchr7107800937-0.0001067740.9998932
ENST00000393561ENST00000413765LAMB1chr7107626467-NRCAMchr7107800937-0.0001067740.9998932
ENST00000393561ENST00000351718LAMB1chr7107626467-NRCAMchr7107800937-0.000109850.9998901
ENST00000393561ENST00000379024LAMB1chr7107626467-NRCAMchr7107800937-0.0001339850.999866
ENST00000393561ENST00000379022LAMB1chr7107626467-NRCAMchr7107800937-0.0018198540.99818015
ENST00000393561ENST00000425651LAMB1chr7107626467-NRCAMchr7107800937-0.0008847280.9991153

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Fusion Genomic Features for LAMB1-NRCAM


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for LAMB1-NRCAM


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:107626467/chr7:107800937)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.NRCAM

Q92823

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Cell adhesion protein that is required for normal responses to cell-cell contacts in brain and in the peripheral nervous system. Plays a role in neurite outgrowth in response to contactin binding. Plays a role in mediating cell-cell contacts between Schwann cells and axons. Plays a role in the formation and maintenance of the nodes of Ranvier on myelinated axons. Nodes of Ranvier contain clustered sodium channels that are crucial for the saltatory propagation of action potentials along myelinated axons. During development, nodes of Ranvier are formed by the fusion of two heminodes. Required for normal clustering of sodium channels at heminodes; not required for the formation of mature nodes with normal sodium channel clusters. Required, together with GLDN, for maintaining NFASC and sodium channel clusters at mature nodes of Ranvier. {ECO:0000250|UniProtKB:Q810U4}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneNRCAMchr7:107626467chr7:107800937ENST0000035171824281064_115610341184.0DomainFibronectin type-III 5
TgeneNRCAMchr7:107626467chr7:107800937ENST0000037902426301064_115610431193.0DomainFibronectin type-III 5
TgeneNRCAMchr7:107626467chr7:107800937ENST0000035171824281191_130410341184.0Topological domainCytoplasmic
TgeneNRCAMchr7:107626467chr7:107800937ENST0000037902426301191_130410431193.0Topological domainCytoplasmic
TgeneNRCAMchr7:107626467chr7:107800937ENST0000037902829331191_130411551305.0Topological domainCytoplasmic
TgeneNRCAMchr7:107626467chr7:107800937ENST0000042565126301191_130411551305.0Topological domainCytoplasmic
TgeneNRCAMchr7:107626467chr7:107800937ENST0000035171824281168_119010341184.0TransmembraneHelical
TgeneNRCAMchr7:107626467chr7:107800937ENST0000037902426301168_119010431193.0TransmembraneHelical
TgeneNRCAMchr7:107626467chr7:107800937ENST0000037902829331168_119011551305.0TransmembraneHelical
TgeneNRCAMchr7:107626467chr7:107800937ENST0000042565126301168_119011551305.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLAMB1chr7:107626467chr7:107800937ENST00000222399-7341216_13152251787.0Coiled coilOntology_term=ECO:0000255
HgeneLAMB1chr7:107626467chr7:107800937ENST00000222399-7341353_13882251787.0Coiled coilOntology_term=ECO:0000255
HgeneLAMB1chr7:107626467chr7:107800937ENST00000222399-7341442_17812251787.0Coiled coilOntology_term=ECO:0000255
HgeneLAMB1chr7:107626467chr7:107800937ENST00000222399-7341028_10832251787.0DomainLaminin EGF-like 11
HgeneLAMB1chr7:107626467chr7:107800937ENST00000222399-7341084_11312251787.0DomainLaminin EGF-like 12
HgeneLAMB1chr7:107626467chr7:107800937ENST00000222399-7341132_11782251787.0DomainLaminin EGF-like 13
HgeneLAMB1chr7:107626467chr7:107800937ENST00000222399-734271_3342251787.0DomainLaminin EGF-like 1
HgeneLAMB1chr7:107626467chr7:107800937ENST00000222399-73431_2702251787.0DomainLaminin N-terminal
HgeneLAMB1chr7:107626467chr7:107800937ENST00000222399-734335_3972251787.0DomainLaminin EGF-like 2
HgeneLAMB1chr7:107626467chr7:107800937ENST00000222399-734398_4572251787.0DomainLaminin EGF-like 3
HgeneLAMB1chr7:107626467chr7:107800937ENST00000222399-734458_5092251787.0DomainLaminin EGF-like 4
HgeneLAMB1chr7:107626467chr7:107800937ENST00000222399-734510_5402251787.0DomainLaminin EGF-like 5%3B truncated
HgeneLAMB1chr7:107626467chr7:107800937ENST00000222399-734549_7672251787.0DomainLaminin IV type B
HgeneLAMB1chr7:107626467chr7:107800937ENST00000222399-734773_8202251787.0DomainLaminin EGF-like 6
HgeneLAMB1chr7:107626467chr7:107800937ENST00000222399-734821_8662251787.0DomainLaminin EGF-like 7
HgeneLAMB1chr7:107626467chr7:107800937ENST00000222399-734867_9162251787.0DomainLaminin EGF-like 8
HgeneLAMB1chr7:107626467chr7:107800937ENST00000222399-734917_9752251787.0DomainLaminin EGF-like 9
HgeneLAMB1chr7:107626467chr7:107800937ENST00000222399-734976_10272251787.0DomainLaminin EGF-like 10
HgeneLAMB1chr7:107626467chr7:107800937ENST00000222399-7341179_13972251787.0RegionNote=Domain II
HgeneLAMB1chr7:107626467chr7:107800937ENST00000222399-7341398_14302251787.0RegionNote=Domain alpha
HgeneLAMB1chr7:107626467chr7:107800937ENST00000222399-7341431_17862251787.0RegionNote=Domain I
TgeneNRCAMchr7:107626467chr7:107800937ENST000003517182428141_23510341184.0DomainNote=Ig-like 2
TgeneNRCAMchr7:107626467chr7:107800937ENST000003517182428267_35610341184.0DomainNote=Ig-like 3
TgeneNRCAMchr7:107626467chr7:107800937ENST000003517182428361_44810341184.0DomainNote=Ig-like 4
TgeneNRCAMchr7:107626467chr7:107800937ENST000003517182428454_54110341184.0DomainNote=Ig-like 5
TgeneNRCAMchr7:107626467chr7:107800937ENST00000351718242846_13410341184.0DomainNote=Ig-like 1
TgeneNRCAMchr7:107626467chr7:107800937ENST000003517182428545_63210341184.0DomainNote=Ig-like 6
TgeneNRCAMchr7:107626467chr7:107800937ENST000003517182428649_74410341184.0DomainFibronectin type-III 1
TgeneNRCAMchr7:107626467chr7:107800937ENST000003517182428746_84310341184.0DomainFibronectin type-III 2
TgeneNRCAMchr7:107626467chr7:107800937ENST000003517182428848_95010341184.0DomainFibronectin type-III 3
TgeneNRCAMchr7:107626467chr7:107800937ENST000003517182428954_105110341184.0DomainFibronectin type-III 4
TgeneNRCAMchr7:107626467chr7:107800937ENST000003790242630141_23510431193.0DomainNote=Ig-like 2
TgeneNRCAMchr7:107626467chr7:107800937ENST000003790242630267_35610431193.0DomainNote=Ig-like 3
TgeneNRCAMchr7:107626467chr7:107800937ENST000003790242630361_44810431193.0DomainNote=Ig-like 4
TgeneNRCAMchr7:107626467chr7:107800937ENST000003790242630454_54110431193.0DomainNote=Ig-like 5
TgeneNRCAMchr7:107626467chr7:107800937ENST00000379024263046_13410431193.0DomainNote=Ig-like 1
TgeneNRCAMchr7:107626467chr7:107800937ENST000003790242630545_63210431193.0DomainNote=Ig-like 6
TgeneNRCAMchr7:107626467chr7:107800937ENST000003790242630649_74410431193.0DomainFibronectin type-III 1
TgeneNRCAMchr7:107626467chr7:107800937ENST000003790242630746_84310431193.0DomainFibronectin type-III 2
TgeneNRCAMchr7:107626467chr7:107800937ENST000003790242630848_95010431193.0DomainFibronectin type-III 3
TgeneNRCAMchr7:107626467chr7:107800937ENST000003790242630954_105110431193.0DomainFibronectin type-III 4
TgeneNRCAMchr7:107626467chr7:107800937ENST0000037902829331064_115611551305.0DomainFibronectin type-III 5
TgeneNRCAMchr7:107626467chr7:107800937ENST000003790282933141_23511551305.0DomainNote=Ig-like 2
TgeneNRCAMchr7:107626467chr7:107800937ENST000003790282933267_35611551305.0DomainNote=Ig-like 3
TgeneNRCAMchr7:107626467chr7:107800937ENST000003790282933361_44811551305.0DomainNote=Ig-like 4
TgeneNRCAMchr7:107626467chr7:107800937ENST000003790282933454_54111551305.0DomainNote=Ig-like 5
TgeneNRCAMchr7:107626467chr7:107800937ENST00000379028293346_13411551305.0DomainNote=Ig-like 1
TgeneNRCAMchr7:107626467chr7:107800937ENST000003790282933545_63211551305.0DomainNote=Ig-like 6
TgeneNRCAMchr7:107626467chr7:107800937ENST000003790282933649_74411551305.0DomainFibronectin type-III 1
TgeneNRCAMchr7:107626467chr7:107800937ENST000003790282933746_84311551305.0DomainFibronectin type-III 2
TgeneNRCAMchr7:107626467chr7:107800937ENST000003790282933848_95011551305.0DomainFibronectin type-III 3
TgeneNRCAMchr7:107626467chr7:107800937ENST000003790282933954_105111551305.0DomainFibronectin type-III 4
TgeneNRCAMchr7:107626467chr7:107800937ENST0000042565126301064_115611551305.0DomainFibronectin type-III 5
TgeneNRCAMchr7:107626467chr7:107800937ENST000004256512630141_23511551305.0DomainNote=Ig-like 2
TgeneNRCAMchr7:107626467chr7:107800937ENST000004256512630267_35611551305.0DomainNote=Ig-like 3
TgeneNRCAMchr7:107626467chr7:107800937ENST000004256512630361_44811551305.0DomainNote=Ig-like 4
TgeneNRCAMchr7:107626467chr7:107800937ENST000004256512630454_54111551305.0DomainNote=Ig-like 5
TgeneNRCAMchr7:107626467chr7:107800937ENST00000425651263046_13411551305.0DomainNote=Ig-like 1
TgeneNRCAMchr7:107626467chr7:107800937ENST000004256512630545_63211551305.0DomainNote=Ig-like 6
TgeneNRCAMchr7:107626467chr7:107800937ENST000004256512630649_74411551305.0DomainFibronectin type-III 1
TgeneNRCAMchr7:107626467chr7:107800937ENST000004256512630746_84311551305.0DomainFibronectin type-III 2
TgeneNRCAMchr7:107626467chr7:107800937ENST000004256512630848_95011551305.0DomainFibronectin type-III 3
TgeneNRCAMchr7:107626467chr7:107800937ENST000004256512630954_105111551305.0DomainFibronectin type-III 4
TgeneNRCAMchr7:107626467chr7:107800937ENST00000351718242825_116710341184.0Topological domainExtracellular
TgeneNRCAMchr7:107626467chr7:107800937ENST00000379024263025_116710431193.0Topological domainExtracellular
TgeneNRCAMchr7:107626467chr7:107800937ENST00000379028293325_116711551305.0Topological domainExtracellular
TgeneNRCAMchr7:107626467chr7:107800937ENST00000425651263025_116711551305.0Topological domainExtracellular


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Fusion Gene Sequence for LAMB1-NRCAM


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>43929_43929_1_LAMB1-NRCAM_LAMB1_chr7_107626467_ENST00000393561_NRCAM_chr7_107800937_ENST00000351718_length(transcript)=3630nt_BP=933nt
GGGGCTGATCAGGGTGGGCGCGAGCGTCGGTGGGTTTCCCGGGAGGGAGGCTCTCGCTGCTGGACAGACCTGATGACGTGTGTGGGTTTC
TTTCCGTGTCCTTCTCCTTTCGGAGTCCCTGCCTTCCCAGCCTCTCCTGCGCTCATCTCTCCATTGTCTTTTCTGTGCATTTTGCTTTCT
TCCGAATGGACTGTCCTCTCTCCGCACCCACTCCCCCGCCCCCGCTTGTTCGTTTTTTTCGGGCTCCACTCCCTGCTTGTGTCCCCCCAA
CTCTGTTGCCTGTCCTTCCCGCAGCCCTGTGCAGAGCCCGAGTGCGCGCTCAGGAACCCGAGTTCAGCTACGGCTGCGCAGAAGGCAGCT
GCTATCCCGCCACGGGCGACCTTCTCATCGGCCGAGCACAGAAGCTTTCGGTGACCTCGACGTGCGGGCTGCACAAGCCCGAACCCTACT
GTATCGTCAGCCACTTGCAGGAGGACAAAAAATGCTTCATATGCAATTCCCAAGATCCTTATCATGAGACCCTGAATCCTGACAGCCATC
TCATTGAAAATGTGGTCACTACATTTGCTCCAAACCGCCTTAAGATTTGGTGGCAATCTGAAAATGGTGTGGAAAATGTAACTATCCAAC
TGGATTTGGAAGCAGAATTCCATTTTACTCATCTCATAATGACTTTCAAGACATTCCGTCCAGCTGCTATGCTGATAGAACGATCGTCCG
ACTTTGGGAAAACCTGGGGTGTGTATAGATACTTCGCCTATGACTGTGAGGCCTCGTTTCCAGGCATTTCAACTGGCCCCATGAAAAAAG
TCGATGACATAATTTGTGATTCTCGATATTCTGACATTGAACCCTCAACTGAAGGAGAGGTGATATTTCGTGCTTTAGATCCTGCTTTCA
AAATAGAAGATCCTTATAGCCCAAGGATACAGACGATGGCAAGCCGGCAGGTGGATATTGCAACTCAGGGCTGGTTCATTGGTCTGATGT
GTGCTGTTGCTCTCCTTATCTTAATTTTGCTGATTGTTTGCTTCATCAGAAGAAACAAGGGTGGTAAATATCCAGTTAAAGAAAAGGAAG
ATGCCCATGCTGACCCTGAAATCCAGCCTATGAAGGAAGATGATGGGACATTTGGAGAATACAGTGATGCAGAAGACCACAAGCCTTTGA
AAAAAGGAAGTCGAACTCCTTCAGACAGGACTGTGAAAAAAGAAGATAGTGACGACAGCCTAGTTGACTATGGAGAAGGGGTTAATGGCC
AGTTCAATGAGGATGGCTCCTTTATTGGACAATACAGTGGTAAGAAAGAGAAAGAGCCGGCTGAAGGAAACGAAAGCTCAGAGGCACCTT
CTCCTGTCAACGCCATGAATTCCTTTGTTTAATTTTTAAGCTCTTTGCCAATATTCCATTTCTCTAGAATGTTTATCCTAAGCACTTGTT
TGTCAGCCCTCTCATACTATGAACATATGGGTAGAGAGTATATTTTCTGCTGTATGTTAGTATTATGAGAATAGTTACAGCAAAAACATA
ACTCAGTCAAATGATATGTTAATATGAACTGGAATGCAAAGTGCATACTTTTTCATTCAAAATGGGTATTCTTGATTTCCTCAGAACTGA
TAAAAAATAATGCAACATCACCAACAGATCCTGTTATTTCCTCTGCAGGATACAGTTCAATATGATGCATGAAAAATGCTCCACATTTAA
AGGACATACCCGTGTATGTTATGAAAACATGGTTTGATACTTTGTTTATACTACCCTCAGCTGAACCCCTATATATGAATTCCGTTTTCA
TTGTCAAGAATGTTACTGTAGTATTCTCTAGAACTTCAATGTCTTTGTGGACATTGTTGTGAAATTGGTGACTATGTATAGCTGTCGTTA
GTCTTTTTGGGAGACTGTTAGGAACAGTTTGTACAGTATATACTTGCTAAATGAGTTCATTATGACAGTCACATTGCTGATGCTTACTGA
GAACTATTACCTACTCTTGGCTCCTGTTACTCCGTAGGCTTCTTAATCTTCCAGGCATTACAGCAGCACAGTGTTCTACTTTTTACATCA
TTTCTATGTTCGGTTGTTTTTAGGCATAAACAATGTGTATTGCAGTGCATTTCGGCATTTGTGCCATACTGAAAGAATCAAAAACAAATC
ATCCAAATTAAATTTCAAACATTATTTCAGAGAACACAGGGCAAGACACATACAGTGCCTTCAGATATTAAGCATTCCACAACATCGTGC
ATTCTGTATCAGCTGGTCCAGTCCATTCTGGGTCCTAGATTACTGTCATTGTCTAAAAGTAACTTTTAAAAAGCAGAGTTCATGAAAACT
GCAATGCTGGGAAAAGAAGGAAACATGAAAATAAAAATAAGACAGTTTATTAGAAATAGCATTTCCTCATAAGCATAAAAAGAAAATCTT
TGTTGCCAACTGAAGCACATGATGATTTTGTGGTCCTTTATGGTTTCTATTACATTCAGTAAGAAAGATGTCAACATGCTAGAAAATTAA
TTTTAAAACTAAGTTATTCCAACACTAAAAGCATACAACAGCATGCCAACAGTAATATATTATTCTCCAAGACTTTACCTATGTAAGTGT
TCAAAACTCTGCAGCATTAAACAACGTGTATGCAAATTGTTATGGATACATTTCAGAATCTAAGAAATCAGGCAAGTGCTTAAAAGGCCA
ACGGTCCAAGGGATTACATCTGCAGTTTAAAAAGTAAATATATATTCTATCGTATTCATAAACAATATCTATCAAATGGGTTACCTCCAA
ATATGAAAATCTATAACAACCTATGGTTGAAGGAATGCTCAGTTTCATTTGCCAATAAATTGGTTTCTCATAACTTGCATCAAGTTTAAT
TTTAAGTAAAGCTTTTTATATGTAGATATTTTGTTGAATTTGTAAATACACTTAAAATGTAGATGCTATATGCTTATAGGTGTTACATAC
AAATAAACATGCAATGTTTATGTTGTACTGTATAAGAGGTAAGCTAATTAATGCAGTGAATGGGATTGGAAAGCATCTACTTAAATATCT
ATTGGGTTCCCCCCTCCCCCCACCTTTTTTGCTGTGAAACTGAAATAGTGAACTTTTCTACGTATTGACAGCAGATTTTTCGATGAAATC
TTCAGAGCTTTGCCTATGGGGCACAGTAGGCCTAGTAACCTGGCATGTTTGATATATGTAGGTAAAGCATAATTTAAAGTAATCCCAGGT
AAAGATGGCCCTAAATACTTTCATGTCTCTATATTCATTTTTCACAGATCCACCTGTCTCTTGAAAATATAAAAAGACAAAACAGGTTTG
CCTTGGCATCAGAGAGCACAAAGATTAAAAGTTACTTTAAATTTGCCAATATTTTGGGAGAACAATAAAACTACATTTTTTCCTCTTCCA
TACTGGTAGATGCGAAATTTATCTGTGCATGAAAGGGTCACTTCTGTAATAGTGCAACAGATTTGGTATTAAAAATTAAATGTGGTTTTA
AAAGTTCCTCTCTCTTTTGTAATTTATGTTCCCAATTGAGTGTGAATGTCCAAGTAATGGTGTATGTAATGGTACAGGCAAATGTGACTG

>43929_43929_1_LAMB1-NRCAM_LAMB1_chr7_107626467_ENST00000393561_NRCAM_chr7_107800937_ENST00000351718_length(amino acids)=441AA_BP=293
MLDRPDDVCGFLSVSFSFRSPCLPSLSCAHLSIVFSVHFAFFRMDCPLSAPTPPPPLVRFFRAPLPACVPPTLLPVLPAALCRARVRAQE
PEFSYGCAEGSCYPATGDLLIGRAQKLSVTSTCGLHKPEPYCIVSHLQEDKKCFICNSQDPYHETLNPDSHLIENVVTTFAPNRLKIWWQ
SENGVENVTIQLDLEAEFHFTHLIMTFKTFRPAAMLIERSSDFGKTWGVYRYFAYDCEASFPGISTGPMKKVDDIICDSRYSDIEPSTEG
EVIFRALDPAFKIEDPYSPRIQTMASRQVDIATQGWFIGLMCAVALLILILLIVCFIRRNKGGKYPVKEKEDAHADPEIQPMKEDDGTFG

--------------------------------------------------------------
>43929_43929_2_LAMB1-NRCAM_LAMB1_chr7_107626467_ENST00000393561_NRCAM_chr7_107800937_ENST00000379022_length(transcript)=1178nt_BP=933nt
GGGGCTGATCAGGGTGGGCGCGAGCGTCGGTGGGTTTCCCGGGAGGGAGGCTCTCGCTGCTGGACAGACCTGATGACGTGTGTGGGTTTC
TTTCCGTGTCCTTCTCCTTTCGGAGTCCCTGCCTTCCCAGCCTCTCCTGCGCTCATCTCTCCATTGTCTTTTCTGTGCATTTTGCTTTCT
TCCGAATGGACTGTCCTCTCTCCGCACCCACTCCCCCGCCCCCGCTTGTTCGTTTTTTTCGGGCTCCACTCCCTGCTTGTGTCCCCCCAA
CTCTGTTGCCTGTCCTTCCCGCAGCCCTGTGCAGAGCCCGAGTGCGCGCTCAGGAACCCGAGTTCAGCTACGGCTGCGCAGAAGGCAGCT
GCTATCCCGCCACGGGCGACCTTCTCATCGGCCGAGCACAGAAGCTTTCGGTGACCTCGACGTGCGGGCTGCACAAGCCCGAACCCTACT
GTATCGTCAGCCACTTGCAGGAGGACAAAAAATGCTTCATATGCAATTCCCAAGATCCTTATCATGAGACCCTGAATCCTGACAGCCATC
TCATTGAAAATGTGGTCACTACATTTGCTCCAAACCGCCTTAAGATTTGGTGGCAATCTGAAAATGGTGTGGAAAATGTAACTATCCAAC
TGGATTTGGAAGCAGAATTCCATTTTACTCATCTCATAATGACTTTCAAGACATTCCGTCCAGCTGCTATGCTGATAGAACGATCGTCCG
ACTTTGGGAAAACCTGGGGTGTGTATAGATACTTCGCCTATGACTGTGAGGCCTCGTTTCCAGGCATTTCAACTGGCCCCATGAAAAAAG
TCGATGACATAATTTGTGATTCTCGATATTCTGACATTGAACCCTCAACTGAAGGAGAGGTGATATTTCGTGCTTTAGATCCTGCTTTCA
AAATAGAAGATCCTTATAGCCCAAGGATACAGACGATGGCAAGCCGGCAGGTGGATATTGCAACTCAGGGCTGGTTCATTGGTCTGATGT
GTGCTGTTGCTCTCCTTATCTTAATTTTGCTGATTGTTTGCTTCATCAGAAGAAACAAGGGTGGTAAATATCCAGTTAAAGAAAAGGAAG
ATGCCCATGCTGACCCTGAAATCCAGCCTATGAAGGAAGATGATGGGACATTTGGAGAATACAGGCTGTTTTCATTTGTTTCTTCTGCAT

>43929_43929_2_LAMB1-NRCAM_LAMB1_chr7_107626467_ENST00000393561_NRCAM_chr7_107800937_ENST00000379022_length(amino acids)=374AA_BP=293
MLDRPDDVCGFLSVSFSFRSPCLPSLSCAHLSIVFSVHFAFFRMDCPLSAPTPPPPLVRFFRAPLPACVPPTLLPVLPAALCRARVRAQE
PEFSYGCAEGSCYPATGDLLIGRAQKLSVTSTCGLHKPEPYCIVSHLQEDKKCFICNSQDPYHETLNPDSHLIENVVTTFAPNRLKIWWQ
SENGVENVTIQLDLEAEFHFTHLIMTFKTFRPAAMLIERSSDFGKTWGVYRYFAYDCEASFPGISTGPMKKVDDIICDSRYSDIEPSTEG
EVIFRALDPAFKIEDPYSPRIQTMASRQVDIATQGWFIGLMCAVALLILILLIVCFIRRNKGGKYPVKEKEDAHADPEIQPMKEDDGTFG

--------------------------------------------------------------
>43929_43929_3_LAMB1-NRCAM_LAMB1_chr7_107626467_ENST00000393561_NRCAM_chr7_107800937_ENST00000379024_length(transcript)=3175nt_BP=933nt
GGGGCTGATCAGGGTGGGCGCGAGCGTCGGTGGGTTTCCCGGGAGGGAGGCTCTCGCTGCTGGACAGACCTGATGACGTGTGTGGGTTTC
TTTCCGTGTCCTTCTCCTTTCGGAGTCCCTGCCTTCCCAGCCTCTCCTGCGCTCATCTCTCCATTGTCTTTTCTGTGCATTTTGCTTTCT
TCCGAATGGACTGTCCTCTCTCCGCACCCACTCCCCCGCCCCCGCTTGTTCGTTTTTTTCGGGCTCCACTCCCTGCTTGTGTCCCCCCAA
CTCTGTTGCCTGTCCTTCCCGCAGCCCTGTGCAGAGCCCGAGTGCGCGCTCAGGAACCCGAGTTCAGCTACGGCTGCGCAGAAGGCAGCT
GCTATCCCGCCACGGGCGACCTTCTCATCGGCCGAGCACAGAAGCTTTCGGTGACCTCGACGTGCGGGCTGCACAAGCCCGAACCCTACT
GTATCGTCAGCCACTTGCAGGAGGACAAAAAATGCTTCATATGCAATTCCCAAGATCCTTATCATGAGACCCTGAATCCTGACAGCCATC
TCATTGAAAATGTGGTCACTACATTTGCTCCAAACCGCCTTAAGATTTGGTGGCAATCTGAAAATGGTGTGGAAAATGTAACTATCCAAC
TGGATTTGGAAGCAGAATTCCATTTTACTCATCTCATAATGACTTTCAAGACATTCCGTCCAGCTGCTATGCTGATAGAACGATCGTCCG
ACTTTGGGAAAACCTGGGGTGTGTATAGATACTTCGCCTATGACTGTGAGGCCTCGTTTCCAGGCATTTCAACTGGCCCCATGAAAAAAG
TCGATGACATAATTTGTGATTCTCGATATTCTGACATTGAACCCTCAACTGAAGGAGAGGTGATATTTCGTGCTTTAGATCCTGCTTTCA
AAATAGAAGATCCTTATAGCCCAAGGATACAGACGATGGCAAGCCGGCAGGTGGATATTGCAACTCAGGGCTGGTTCATTGGTCTGATGT
GTGCTGTTGCTCTCCTTATCTTAATTTTGCTGATTGTTTGCTTCATCAGAAGAAACAAGGGTGGTAAATATCCAGTTAAAGAAAAGGAAG
ATGCCCATGCTGACCCTGAAATCCAGCCTATGAAGGAAGATGATGGGACATTTGGAGAATACAGTGATGCAGAAGACCACAAGCCTTTGA
AAAAAGGAAGTCGAACTCCTTCAGACAGGACTGTGAAAAAAGAAGATAGTGACGACAGCCTAGTTGACTATGGAGAAGGGGTTAATGGCC
AGTTCAATGAGGATGGCTCCTTTATTGGACAATACAGTGGTAAGAAAGAGAAAGAGCCGGCTGAAGGAAACGAAAGCTCAGAGGCACCTT
CTCCTGTCAACGCCATGAATTCCTTTGTTTAATTTTTAAGCTCTTTGCCAATATTCCATTTCTCTAGAATGTTTATCCTAAGCACTTGTT
TGTCAGCCCTCTCATACTATGAACATATGGGTAGAGAGTATATTTTCTGCTGTATGTTAGTATTATGAGAATAGTTACAGCAAAAACATA
ACTCAGTCAAATGATATGTTAATATGAACTGGAATGCAAAGTGCATACTTTTTCATTCAAAATGGGTATTCTTGATTTCCTCAGAACTGA
TAAAAAATAATGCAACATCACCAACAGATCCTGTTATTTCCTCTGCAGGATACAGTTCAATATGATGCATGAAAAATGCTCCACATTTAA
AGGACATACCCGTGTATGTTATGAAAACATGGTTTGATACTTTGTTTATACTACCCTCAGCTGAACCCCTATATATGAATTCCGTTTTCA
TTGTCAAGAATGTTACTGTAGTATTCTCTAGAACTTCAATGTCTTTGTGGACATTGTTGTGAAATTGGTGACTATGTATAGCTGTCGTTA
GTCTTTTTGGGAGACTGTTAGGAACAGTTTGTACAGTATATACTTGCTAAATGAGTTCATTATGACAGTCACATTGCTGATGCTTACTGA
GAACTATTACCTACTCTTGGCTCCTGTTACTCCGTAGGCTTCTTAATCTTCCAGGCATTACAGCAGCACAGTGTTCTACTTTTTACATCA
TTTCTATGTTCGGTTGTTTTTAGGCATAAACAATGTGTATTGCAGTGCATTTCGGCATTTGTGCCATACTGAAAGAATCAAAAACAAATC
ATCCAAATTAAATTTCAAACATTATTTCAGAGAACACAGGGCAAGACACATACAGTGCCTTCAGATATTAAGCATTCCACAACATCGTGC
ATTCTGTATCAGCTGGTCCAGTCCATTCTGGGTCCTAGATTACTGTCATTGTCTAAAAGTAACTTTTAAAAAGCAGAGTTCATGAAAACT
GCAATGCTGGGAAAAGAAGGAAACATGAAAATAAAAATAAGACAGTTTATTAGAAATAGCATTTCCTCATAAGCATAAAAAGAAAATCTT
TGTTGCCAACTGAAGCACATGATGATTTTGTGGTCCTTTATGGTTTCTATTACATTCAGTAAGAAAGATGTCAACATGCTAGAAAATTAA
TTTTAAAACTAAGTTATTCCAACACTAAAAGCATACAACAGCATGCCAACAGTAATATATTATTCTCCAAGACTTTACCTATGTAAGTGT
TCAAAACTCTGCAGCATTAAACAACGTGTATGCAAATTGTTATGGATACATTTCAGAATCTAAGAAATCAGGCAAGTGCTTAAAAGGCCA
ACGGTCCAAGGGATTACATCTGCAGTTTAAAAAGTAAATATATATTCTATCGTATTCATAAACAATATCTATCAAATGGGTTACCTCCAA
ATATGAAAATCTATAACAACCTATGGTTGAAGGAATGCTCAGTTTCATTTGCCAATAAATTGGTTTCTCATAACTTGCATCAAGTTTAAT
TTTAAGTAAAGCTTTTTATATGTAGATATTTTGTTGAATTTGTAAATACACTTAAAATGTAGATGCTATATGCTTATAGGTGTTACATAC
AAATAAACATGCAATGTTTATGTTGTACTGTATAAGAGGTAAGCTAATTAATGCAGTGAATGGGATTGGAAAGCATCTACTTAAATATCT
ATTGGGTTCCCCCCTCCCCCCACCTTTTTTGCTGTGAAACTGAAATAGTGAACTTTTCTACGTATTGACAGCAGATTTTTCGATGAAATC

>43929_43929_3_LAMB1-NRCAM_LAMB1_chr7_107626467_ENST00000393561_NRCAM_chr7_107800937_ENST00000379024_length(amino acids)=441AA_BP=293
MLDRPDDVCGFLSVSFSFRSPCLPSLSCAHLSIVFSVHFAFFRMDCPLSAPTPPPPLVRFFRAPLPACVPPTLLPVLPAALCRARVRAQE
PEFSYGCAEGSCYPATGDLLIGRAQKLSVTSTCGLHKPEPYCIVSHLQEDKKCFICNSQDPYHETLNPDSHLIENVVTTFAPNRLKIWWQ
SENGVENVTIQLDLEAEFHFTHLIMTFKTFRPAAMLIERSSDFGKTWGVYRYFAYDCEASFPGISTGPMKKVDDIICDSRYSDIEPSTEG
EVIFRALDPAFKIEDPYSPRIQTMASRQVDIATQGWFIGLMCAVALLILILLIVCFIRRNKGGKYPVKEKEDAHADPEIQPMKEDDGTFG

--------------------------------------------------------------
>43929_43929_4_LAMB1-NRCAM_LAMB1_chr7_107626467_ENST00000393561_NRCAM_chr7_107800937_ENST00000379028_length(transcript)=3655nt_BP=933nt
GGGGCTGATCAGGGTGGGCGCGAGCGTCGGTGGGTTTCCCGGGAGGGAGGCTCTCGCTGCTGGACAGACCTGATGACGTGTGTGGGTTTC
TTTCCGTGTCCTTCTCCTTTCGGAGTCCCTGCCTTCCCAGCCTCTCCTGCGCTCATCTCTCCATTGTCTTTTCTGTGCATTTTGCTTTCT
TCCGAATGGACTGTCCTCTCTCCGCACCCACTCCCCCGCCCCCGCTTGTTCGTTTTTTTCGGGCTCCACTCCCTGCTTGTGTCCCCCCAA
CTCTGTTGCCTGTCCTTCCCGCAGCCCTGTGCAGAGCCCGAGTGCGCGCTCAGGAACCCGAGTTCAGCTACGGCTGCGCAGAAGGCAGCT
GCTATCCCGCCACGGGCGACCTTCTCATCGGCCGAGCACAGAAGCTTTCGGTGACCTCGACGTGCGGGCTGCACAAGCCCGAACCCTACT
GTATCGTCAGCCACTTGCAGGAGGACAAAAAATGCTTCATATGCAATTCCCAAGATCCTTATCATGAGACCCTGAATCCTGACAGCCATC
TCATTGAAAATGTGGTCACTACATTTGCTCCAAACCGCCTTAAGATTTGGTGGCAATCTGAAAATGGTGTGGAAAATGTAACTATCCAAC
TGGATTTGGAAGCAGAATTCCATTTTACTCATCTCATAATGACTTTCAAGACATTCCGTCCAGCTGCTATGCTGATAGAACGATCGTCCG
ACTTTGGGAAAACCTGGGGTGTGTATAGATACTTCGCCTATGACTGTGAGGCCTCGTTTCCAGGCATTTCAACTGGCCCCATGAAAAAAG
TCGATGACATAATTTGTGATTCTCGATATTCTGACATTGAACCCTCAACTGAAGGAGAGGTGATATTTCGTGCTTTAGATCCTGCTTTCA
AAATAGAAGATCCTTATAGCCCAAGGATACAGACGATGGCAAGCCGGCAGGTGGATATTGCAACTCAGGGCTGGTTCATTGGTCTGATGT
GTGCTGTTGCTCTCCTTATCTTAATTTTGCTGATTGTTTGCTTCATCAGAAGAAACAAGGGTGGTAAATATCCAGTTAAAGAAAAGGAAG
ATGCCCATGCTGACCCTGAAATCCAGCCTATGAAGGAAGATGATGGGACATTTGGAGAATACAGTGATGCAGAAGACCACAAGCCTTTGA
AAAAAGGAAGTCGAACTCCTTCAGACAGGACTGTGAAAAAAGAAGATAGTGACGACAGCCTAGTTGACTATGGAGAAGGGGTTAATGGCC
AGTTCAATGAGGATGGCTCCTTTATTGGACAATACAGTGGTAAGAAAGAGAAAGAGCCGGCTGAAGGAAACGAAAGCTCAGAGGCACCTT
CTCCTGTCAACGCCATGAATTCCTTTGTTTAATTTTTAAGCTCTTTGCCAATATTCCATTTCTCTAGAATGTTTATCCTAAGCACTTGTT
TGTCAGCCCTCTCATACTATGAACATATGGGTAGAGAGTATATTTTCTGCTGTATGTTAGTATTATGAGAATAGTTACAGCAAAAACATA
ACTCAGTCAAATGATATGTTAATATGAACTGGAATGCAAAGTGCATACTTTTTCATTCAAAATGGGTATTCTTGATTTCCTCAGAACTGA
TAAAAAATAATGCAACATCACCAACAGATCCTGTTATTTCCTCTGCAGGATACAGTTCAATATGATGCATGAAAAATGCTCCACATTTAA
AGGACATACCCGTGTATGTTATGAAAACATGGTTTGATACTTTGTTTATACTACCCTCAGCTGAACCCCTATATATGAATTCCGTTTTCA
TTGTCAAGAATGTTACTGTAGTATTCTCTAGAACTTCAATGTCTTTGTGGACATTGTTGTGAAATTGGTGACTATGTATAGCTGTCGTTA
GTCTTTTTGGGAGACTGTTAGGAACAGTTTGTACAGTATATACTTGCTAAATGAGTTCATTATGACAGTCACATTGCTGATGCTTACTGA
GAACTATTACCTACTCTTGGCTCCTGTTACTCCGTAGGCTTCTTAATCTTCCAGGCATTACAGCAGCACAGTGTTCTACTTTTTACATCA
TTTCTATGTTCGGTTGTTTTTAGGCATAAACAATGTGTATTGCAGTGCATTTCGGCATTTGTGCCATACTGAAAGAATCAAAAACAAATC
ATCCAAATTAAATTTCAAACATTATTTCAGAGAACACAGGGCAAGACACATACAGTGCCTTCAGATATTAAGCATTCCACAACATCGTGC
ATTCTGTATCAGCTGGTCCAGTCCATTCTGGGTCCTAGATTACTGTCATTGTCTAAAAGTAACTTTTAAAAAGCAGAGTTCATGAAAACT
GCAATGCTGGGAAAAGAAGGAAACATGAAAATAAAAATAAGACAGTTTATTAGAAATAGCATTTCCTCATAAGCATAAAAAGAAAATCTT
TGTTGCCAACTGAAGCACATGATGATTTTGTGGTCCTTTATGGTTTCTATTACATTCAGTAAGAAAGATGTCAACATGCTAGAAAATTAA
TTTTAAAACTAAGTTATTCCAACACTAAAAGCATACAACAGCATGCCAACAGTAATATATTATTCTCCAAGACTTTACCTATGTAAGTGT
TCAAAACTCTGCAGCATTAAACAACGTGTATGCAAATTGTTATGGATACATTTCAGAATCTAAGAAATCAGGCAAGTGCTTAAAAGGCCA
ACGGTCCAAGGGATTACATCTGCAGTTTAAAAAGTAAATATATATTCTATCGTATTCATAAACAATATCTATCAAATGGGTTACCTCCAA
ATATGAAAATCTATAACAACCTATGGTTGAAGGAATGCTCAGTTTCATTTGCCAATAAATTGGTTTCTCATAACTTGCATCAAGTTTAAT
TTTAAGTAAAGCTTTTTATATGTAGATATTTTGTTGAATTTGTAAATACACTTAAAATGTAGATGCTATATGCTTATAGGTGTTACATAC
AAATAAACATGCAATGTTTATGTTGTACTGTATAAGAGGTAAGCTAATTAATGCAGTGAATGGGATTGGAAAGCATCTACTTAAATATCT
ATTGGGTTCCCCCCTCCCCCCACCTTTTTTGCTGTGAAACTGAAATAGTGAACTTTTCTACGTATTGACAGCAGATTTTTCGATGAAATC
TTCAGAGCTTTGCCTATGGGGCACAGTAGGCCTAGTAACCTGGCATGTTTGATATATGTAGGTAAAGCATAATTTAAAGTAATCCCAGGT
AAAGATGGCCCTAAATACTTTCATGTCTCTATATTCATTTTTCACAGATCCACCTGTCTCTTGAAAATATAAAAAGACAAAACAGGTTTG
CCTTGGCATCAGAGAGCACAAAGATTAAAAGTTACTTTAAATTTGCCAATATTTTGGGAGAACAATAAAACTACATTTTTTCCTCTTCCA
TACTGGTAGATGCGAAATTTATCTGTGCATGAAAGGGTCACTTCTGTAATAGTGCAACAGATTTGGTATTAAAAATTAAATGTGGTTTTA
AAAGTTCCTCTCTCTTTTGTAATTTATGTTCCCAATTGAGTGTGAATGTCCAAGTAATGGTGTATGTAATGGTACAGGCAAATGTGACTG

>43929_43929_4_LAMB1-NRCAM_LAMB1_chr7_107626467_ENST00000393561_NRCAM_chr7_107800937_ENST00000379028_length(amino acids)=441AA_BP=293
MLDRPDDVCGFLSVSFSFRSPCLPSLSCAHLSIVFSVHFAFFRMDCPLSAPTPPPPLVRFFRAPLPACVPPTLLPVLPAALCRARVRAQE
PEFSYGCAEGSCYPATGDLLIGRAQKLSVTSTCGLHKPEPYCIVSHLQEDKKCFICNSQDPYHETLNPDSHLIENVVTTFAPNRLKIWWQ
SENGVENVTIQLDLEAEFHFTHLIMTFKTFRPAAMLIERSSDFGKTWGVYRYFAYDCEASFPGISTGPMKKVDDIICDSRYSDIEPSTEG
EVIFRALDPAFKIEDPYSPRIQTMASRQVDIATQGWFIGLMCAVALLILILLIVCFIRRNKGGKYPVKEKEDAHADPEIQPMKEDDGTFG

--------------------------------------------------------------
>43929_43929_5_LAMB1-NRCAM_LAMB1_chr7_107626467_ENST00000393561_NRCAM_chr7_107800937_ENST00000413765_length(transcript)=3655nt_BP=933nt
GGGGCTGATCAGGGTGGGCGCGAGCGTCGGTGGGTTTCCCGGGAGGGAGGCTCTCGCTGCTGGACAGACCTGATGACGTGTGTGGGTTTC
TTTCCGTGTCCTTCTCCTTTCGGAGTCCCTGCCTTCCCAGCCTCTCCTGCGCTCATCTCTCCATTGTCTTTTCTGTGCATTTTGCTTTCT
TCCGAATGGACTGTCCTCTCTCCGCACCCACTCCCCCGCCCCCGCTTGTTCGTTTTTTTCGGGCTCCACTCCCTGCTTGTGTCCCCCCAA
CTCTGTTGCCTGTCCTTCCCGCAGCCCTGTGCAGAGCCCGAGTGCGCGCTCAGGAACCCGAGTTCAGCTACGGCTGCGCAGAAGGCAGCT
GCTATCCCGCCACGGGCGACCTTCTCATCGGCCGAGCACAGAAGCTTTCGGTGACCTCGACGTGCGGGCTGCACAAGCCCGAACCCTACT
GTATCGTCAGCCACTTGCAGGAGGACAAAAAATGCTTCATATGCAATTCCCAAGATCCTTATCATGAGACCCTGAATCCTGACAGCCATC
TCATTGAAAATGTGGTCACTACATTTGCTCCAAACCGCCTTAAGATTTGGTGGCAATCTGAAAATGGTGTGGAAAATGTAACTATCCAAC
TGGATTTGGAAGCAGAATTCCATTTTACTCATCTCATAATGACTTTCAAGACATTCCGTCCAGCTGCTATGCTGATAGAACGATCGTCCG
ACTTTGGGAAAACCTGGGGTGTGTATAGATACTTCGCCTATGACTGTGAGGCCTCGTTTCCAGGCATTTCAACTGGCCCCATGAAAAAAG
TCGATGACATAATTTGTGATTCTCGATATTCTGACATTGAACCCTCAACTGAAGGAGAGGTGATATTTCGTGCTTTAGATCCTGCTTTCA
AAATAGAAGATCCTTATAGCCCAAGGATACAGACGATGGCAAGCCGGCAGGTGGATATTGCAACTCAGGGCTGGTTCATTGGTCTGATGT
GTGCTGTTGCTCTCCTTATCTTAATTTTGCTGATTGTTTGCTTCATCAGAAGAAACAAGGGTGGTAAATATCCAGTTAAAGAAAAGGAAG
ATGCCCATGCTGACCCTGAAATCCAGCCTATGAAGGAAGATGATGGGACATTTGGAGAATACAGTGATGCAGAAGACCACAAGCCTTTGA
AAAAAGGAAGTCGAACTCCTTCAGACAGGACTGTGAAAAAAGAAGATAGTGACGACAGCCTAGTTGACTATGGAGAAGGGGTTAATGGCC
AGTTCAATGAGGATGGCTCCTTTATTGGACAATACAGTGGTAAGAAAGAGAAAGAGCCGGCTGAAGGAAACGAAAGCTCAGAGGCACCTT
CTCCTGTCAACGCCATGAATTCCTTTGTTTAATTTTTAAGCTCTTTGCCAATATTCCATTTCTCTAGAATGTTTATCCTAAGCACTTGTT
TGTCAGCCCTCTCATACTATGAACATATGGGTAGAGAGTATATTTTCTGCTGTATGTTAGTATTATGAGAATAGTTACAGCAAAAACATA
ACTCAGTCAAATGATATGTTAATATGAACTGGAATGCAAAGTGCATACTTTTTCATTCAAAATGGGTATTCTTGATTTCCTCAGAACTGA
TAAAAAATAATGCAACATCACCAACAGATCCTGTTATTTCCTCTGCAGGATACAGTTCAATATGATGCATGAAAAATGCTCCACATTTAA
AGGACATACCCGTGTATGTTATGAAAACATGGTTTGATACTTTGTTTATACTACCCTCAGCTGAACCCCTATATATGAATTCCGTTTTCA
TTGTCAAGAATGTTACTGTAGTATTCTCTAGAACTTCAATGTCTTTGTGGACATTGTTGTGAAATTGGTGACTATGTATAGCTGTCGTTA
GTCTTTTTGGGAGACTGTTAGGAACAGTTTGTACAGTATATACTTGCTAAATGAGTTCATTATGACAGTCACATTGCTGATGCTTACTGA
GAACTATTACCTACTCTTGGCTCCTGTTACTCCGTAGGCTTCTTAATCTTCCAGGCATTACAGCAGCACAGTGTTCTACTTTTTACATCA
TTTCTATGTTCGGTTGTTTTTAGGCATAAACAATGTGTATTGCAGTGCATTTCGGCATTTGTGCCATACTGAAAGAATCAAAAACAAATC
ATCCAAATTAAATTTCAAACATTATTTCAGAGAACACAGGGCAAGACACATACAGTGCCTTCAGATATTAAGCATTCCACAACATCGTGC
ATTCTGTATCAGCTGGTCCAGTCCATTCTGGGTCCTAGATTACTGTCATTGTCTAAAAGTAACTTTTAAAAAGCAGAGTTCATGAAAACT
GCAATGCTGGGAAAAGAAGGAAACATGAAAATAAAAATAAGACAGTTTATTAGAAATAGCATTTCCTCATAAGCATAAAAAGAAAATCTT
TGTTGCCAACTGAAGCACATGATGATTTTGTGGTCCTTTATGGTTTCTATTACATTCAGTAAGAAAGATGTCAACATGCTAGAAAATTAA
TTTTAAAACTAAGTTATTCCAACACTAAAAGCATACAACAGCATGCCAACAGTAATATATTATTCTCCAAGACTTTACCTATGTAAGTGT
TCAAAACTCTGCAGCATTAAACAACGTGTATGCAAATTGTTATGGATACATTTCAGAATCTAAGAAATCAGGCAAGTGCTTAAAAGGCCA
ACGGTCCAAGGGATTACATCTGCAGTTTAAAAAGTAAATATATATTCTATCGTATTCATAAACAATATCTATCAAATGGGTTACCTCCAA
ATATGAAAATCTATAACAACCTATGGTTGAAGGAATGCTCAGTTTCATTTGCCAATAAATTGGTTTCTCATAACTTGCATCAAGTTTAAT
TTTAAGTAAAGCTTTTTATATGTAGATATTTTGTTGAATTTGTAAATACACTTAAAATGTAGATGCTATATGCTTATAGGTGTTACATAC
AAATAAACATGCAATGTTTATGTTGTACTGTATAAGAGGTAAGCTAATTAATGCAGTGAATGGGATTGGAAAGCATCTACTTAAATATCT
ATTGGGTTCCCCCCTCCCCCCACCTTTTTTGCTGTGAAACTGAAATAGTGAACTTTTCTACGTATTGACAGCAGATTTTTCGATGAAATC
TTCAGAGCTTTGCCTATGGGGCACAGTAGGCCTAGTAACCTGGCATGTTTGATATATGTAGGTAAAGCATAATTTAAAGTAATCCCAGGT
AAAGATGGCCCTAAATACTTTCATGTCTCTATATTCATTTTTCACAGATCCACCTGTCTCTTGAAAATATAAAAAGACAAAACAGGTTTG
CCTTGGCATCAGAGAGCACAAAGATTAAAAGTTACTTTAAATTTGCCAATATTTTGGGAGAACAATAAAACTACATTTTTTCCTCTTCCA
TACTGGTAGATGCGAAATTTATCTGTGCATGAAAGGGTCACTTCTGTAATAGTGCAACAGATTTGGTATTAAAAATTAAATGTGGTTTTA
AAAGTTCCTCTCTCTTTTGTAATTTATGTTCCCAATTGAGTGTGAATGTCCAAGTAATGGTGTATGTAATGGTACAGGCAAATGTGACTG

>43929_43929_5_LAMB1-NRCAM_LAMB1_chr7_107626467_ENST00000393561_NRCAM_chr7_107800937_ENST00000413765_length(amino acids)=441AA_BP=293
MLDRPDDVCGFLSVSFSFRSPCLPSLSCAHLSIVFSVHFAFFRMDCPLSAPTPPPPLVRFFRAPLPACVPPTLLPVLPAALCRARVRAQE
PEFSYGCAEGSCYPATGDLLIGRAQKLSVTSTCGLHKPEPYCIVSHLQEDKKCFICNSQDPYHETLNPDSHLIENVVTTFAPNRLKIWWQ
SENGVENVTIQLDLEAEFHFTHLIMTFKTFRPAAMLIERSSDFGKTWGVYRYFAYDCEASFPGISTGPMKKVDDIICDSRYSDIEPSTEG
EVIFRALDPAFKIEDPYSPRIQTMASRQVDIATQGWFIGLMCAVALLILILLIVCFIRRNKGGKYPVKEKEDAHADPEIQPMKEDDGTFG

--------------------------------------------------------------
>43929_43929_6_LAMB1-NRCAM_LAMB1_chr7_107626467_ENST00000393561_NRCAM_chr7_107800937_ENST00000425651_length(transcript)=1382nt_BP=933nt
GGGGCTGATCAGGGTGGGCGCGAGCGTCGGTGGGTTTCCCGGGAGGGAGGCTCTCGCTGCTGGACAGACCTGATGACGTGTGTGGGTTTC
TTTCCGTGTCCTTCTCCTTTCGGAGTCCCTGCCTTCCCAGCCTCTCCTGCGCTCATCTCTCCATTGTCTTTTCTGTGCATTTTGCTTTCT
TCCGAATGGACTGTCCTCTCTCCGCACCCACTCCCCCGCCCCCGCTTGTTCGTTTTTTTCGGGCTCCACTCCCTGCTTGTGTCCCCCCAA
CTCTGTTGCCTGTCCTTCCCGCAGCCCTGTGCAGAGCCCGAGTGCGCGCTCAGGAACCCGAGTTCAGCTACGGCTGCGCAGAAGGCAGCT
GCTATCCCGCCACGGGCGACCTTCTCATCGGCCGAGCACAGAAGCTTTCGGTGACCTCGACGTGCGGGCTGCACAAGCCCGAACCCTACT
GTATCGTCAGCCACTTGCAGGAGGACAAAAAATGCTTCATATGCAATTCCCAAGATCCTTATCATGAGACCCTGAATCCTGACAGCCATC
TCATTGAAAATGTGGTCACTACATTTGCTCCAAACCGCCTTAAGATTTGGTGGCAATCTGAAAATGGTGTGGAAAATGTAACTATCCAAC
TGGATTTGGAAGCAGAATTCCATTTTACTCATCTCATAATGACTTTCAAGACATTCCGTCCAGCTGCTATGCTGATAGAACGATCGTCCG
ACTTTGGGAAAACCTGGGGTGTGTATAGATACTTCGCCTATGACTGTGAGGCCTCGTTTCCAGGCATTTCAACTGGCCCCATGAAAAAAG
TCGATGACATAATTTGTGATTCTCGATATTCTGACATTGAACCCTCAACTGAAGGAGAGGTGATATTTCGTGCTTTAGATCCTGCTTTCA
AAATAGAAGATCCTTATAGCCCAAGGATACAGACGATGGCAAGCCGGCAGGTGGATATTGCAACTCAGGGCTGGTTCATTGGTCTGATGT
GTGCTGTTGCTCTCCTTATCTTAATTTTGCTGATTGTTTGCTTCATCAGAAGAAACAAGGGTGGTAAATATCCAGTTAAAGAAAAGGAAG
ATGCCCATGCTGACCCTGAAATCCAGCCTATGAAGGAAGATGATGGGACATTTGGAGAATACAGTGATGCAGAAGACCACAAGCCTTTGA
AAAAAGGAAGTCGAACTCCTTCAGACAGGACTGTGAAAAAAGAAGATAGTGACGACAGCCTAGTTGACTATGGAGAAGGGGTTAATGGCC
AGTTCAATGAGGATGGCTCCTTTATTGGACAATACAGTGGTAAGAAAGAGAAAGAGCCGGCTGAAGGAAACGAAAGCTCAGAGGCACCTT

>43929_43929_6_LAMB1-NRCAM_LAMB1_chr7_107626467_ENST00000393561_NRCAM_chr7_107800937_ENST00000425651_length(amino acids)=442AA_BP=293
MLDRPDDVCGFLSVSFSFRSPCLPSLSCAHLSIVFSVHFAFFRMDCPLSAPTPPPPLVRFFRAPLPACVPPTLLPVLPAALCRARVRAQE
PEFSYGCAEGSCYPATGDLLIGRAQKLSVTSTCGLHKPEPYCIVSHLQEDKKCFICNSQDPYHETLNPDSHLIENVVTTFAPNRLKIWWQ
SENGVENVTIQLDLEAEFHFTHLIMTFKTFRPAAMLIERSSDFGKTWGVYRYFAYDCEASFPGISTGPMKKVDDIICDSRYSDIEPSTEG
EVIFRALDPAFKIEDPYSPRIQTMASRQVDIATQGWFIGLMCAVALLILILLIVCFIRRNKGGKYPVKEKEDAHADPEIQPMKEDDGTFG

--------------------------------------------------------------

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Fusion Gene PPI Analysis for LAMB1-NRCAM


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for LAMB1-NRCAM


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for LAMB1-NRCAM


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource