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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:LAMB1-PARP14 (FusionGDB2 ID:43930)

Fusion Gene Summary for LAMB1-PARP14

check button Fusion gene summary
Fusion gene informationFusion gene name: LAMB1-PARP14
Fusion gene ID: 43930
HgeneTgene
Gene symbol

LAMB1

PARP14

Gene ID

3912

54625

Gene namelaminin subunit beta 1poly(ADP-ribose) polymerase family member 14
SynonymsCLM|LIS5ARTD8|BAL2|PARP-14|pART8
Cytomap

7q31.1

3q21.1

Type of geneprotein-codingprotein-coding
Descriptionlaminin subunit beta-1laminin B1 chainlaminin, beta 1protein mono-ADP-ribosyltransferase PARP14ADP-ribosyltransferase diphtheria toxin-like 8B-aggressive lymphoma 2b aggressive lymphoma protein 2collaborator of STAT6poly [ADP-ribose] polymerase 14
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000222399, ENST00000393560, 
ENST00000393561, ENST00000474380, 
ENST00000475640, ENST00000474629, 
Fusion gene scores* DoF score11 X 11 X 5=60512 X 9 X 6=648
# samples 1315
** MAII scorelog2(13/605*10)=-2.2184235191335
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/648*10)=-2.11103131238874
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: LAMB1 [Title/Abstract] AND PARP14 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointLAMB1(107635332)-PARP14(122446659), # samples:1
LAMB1(107591670)-PARP14(122446658), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneLAMB1

GO:0030335

positive regulation of cell migration

16289578

HgeneLAMB1

GO:0031175

neuron projection development

15894315

HgeneLAMB1

GO:0034446

substrate adhesion-dependent cell spreading

16236823

HgeneLAMB1

GO:0042476

odontogenesis

15894315

TgenePARP14

GO:0006471

protein ADP-ribosylation

27796300


check buttonFusion gene breakpoints across LAMB1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PARP14 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-C8-A134-01ALAMB1chr7

107635332

-PARP14chr3

122446659

+
ChimerDB4UCECTCGA-DI-A1C3LAMB1chr7

107591670

-PARP14chr3

122446658

+


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Fusion Gene ORF analysis for LAMB1-PARP14

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000222399ENST00000475640LAMB1chr7

107635332

-PARP14chr3

122446659

+
5CDS-intronENST00000222399ENST00000475640LAMB1chr7

107591670

-PARP14chr3

122446658

+
5CDS-intronENST00000393560ENST00000475640LAMB1chr7

107635332

-PARP14chr3

122446659

+
5CDS-intronENST00000393561ENST00000475640LAMB1chr7

107635332

-PARP14chr3

122446659

+
5CDS-intronENST00000393561ENST00000475640LAMB1chr7

107591670

-PARP14chr3

122446658

+
Frame-shiftENST00000222399ENST00000474629LAMB1chr7

107635332

-PARP14chr3

122446659

+
Frame-shiftENST00000393560ENST00000474629LAMB1chr7

107635332

-PARP14chr3

122446659

+
Frame-shiftENST00000393561ENST00000474629LAMB1chr7

107591670

-PARP14chr3

122446658

+
In-frameENST00000222399ENST00000474629LAMB1chr7

107591670

-PARP14chr3

122446658

+
In-frameENST00000393561ENST00000474629LAMB1chr7

107635332

-PARP14chr3

122446659

+
intron-3CDSENST00000393560ENST00000474629LAMB1chr7

107591670

-PARP14chr3

122446658

+
intron-3CDSENST00000474380ENST00000474629LAMB1chr7

107635332

-PARP14chr3

122446659

+
intron-3CDSENST00000474380ENST00000474629LAMB1chr7

107591670

-PARP14chr3

122446658

+
intron-intronENST00000393560ENST00000475640LAMB1chr7

107591670

-PARP14chr3

122446658

+
intron-intronENST00000474380ENST00000475640LAMB1chr7

107635332

-PARP14chr3

122446659

+
intron-intronENST00000474380ENST00000475640LAMB1chr7

107591670

-PARP14chr3

122446658

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000393561LAMB1chr7107635332-ENST00000474629PARP14chr3122446659+3388680561144362
ENST00000222399LAMB1chr7107591670-ENST00000474629PARP14chr3122446658+633036229936261175

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000393561ENST00000474629LAMB1chr7107635332-PARP14chr3122446659+0.0006748690.99932516
ENST00000222399ENST00000474629LAMB1chr7107591670-PARP14chr3122446658+0.0001887540.99981123

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Fusion Genomic Features for LAMB1-PARP14


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
LAMB1chr7107591670-PARP14chr3122446658+4.11E-050.999959
LAMB1chr7107635331-PARP14chr3122446658+2.50E-091
LAMB1chr7107591670-PARP14chr3122446658+4.11E-050.999959
LAMB1chr7107635331-PARP14chr3122446658+2.50E-091

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for LAMB1-PARP14


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:107635332/chr3:122446659)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLAMB1chr7:107591670chr3:122446658ENST00000222399-24341028_108311301787.0DomainLaminin EGF-like 11
HgeneLAMB1chr7:107591670chr3:122446658ENST00000222399-24341084_113111301787.0DomainLaminin EGF-like 12
HgeneLAMB1chr7:107591670chr3:122446658ENST00000222399-2434271_33411301787.0DomainLaminin EGF-like 1
HgeneLAMB1chr7:107591670chr3:122446658ENST00000222399-243431_27011301787.0DomainLaminin N-terminal
HgeneLAMB1chr7:107591670chr3:122446658ENST00000222399-2434335_39711301787.0DomainLaminin EGF-like 2
HgeneLAMB1chr7:107591670chr3:122446658ENST00000222399-2434398_45711301787.0DomainLaminin EGF-like 3
HgeneLAMB1chr7:107591670chr3:122446658ENST00000222399-2434458_50911301787.0DomainLaminin EGF-like 4
HgeneLAMB1chr7:107591670chr3:122446658ENST00000222399-2434510_54011301787.0DomainLaminin EGF-like 5%3B truncated
HgeneLAMB1chr7:107591670chr3:122446658ENST00000222399-2434549_76711301787.0DomainLaminin IV type B
HgeneLAMB1chr7:107591670chr3:122446658ENST00000222399-2434773_82011301787.0DomainLaminin EGF-like 6
HgeneLAMB1chr7:107591670chr3:122446658ENST00000222399-2434821_86611301787.0DomainLaminin EGF-like 7
HgeneLAMB1chr7:107591670chr3:122446658ENST00000222399-2434867_91611301787.0DomainLaminin EGF-like 8
HgeneLAMB1chr7:107591670chr3:122446658ENST00000222399-2434917_97511301787.0DomainLaminin EGF-like 9
HgeneLAMB1chr7:107591670chr3:122446658ENST00000222399-2434976_102711301787.0DomainLaminin EGF-like 10

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLAMB1chr7:107591670chr3:122446658ENST00000222399-24341216_131511301787.0Coiled coilOntology_term=ECO:0000255
HgeneLAMB1chr7:107591670chr3:122446658ENST00000222399-24341353_138811301787.0Coiled coilOntology_term=ECO:0000255
HgeneLAMB1chr7:107591670chr3:122446658ENST00000222399-24341442_178111301787.0Coiled coilOntology_term=ECO:0000255
HgeneLAMB1chr7:107635332chr3:122446659ENST00000222399-5341216_13151411787.0Coiled coilOntology_term=ECO:0000255
HgeneLAMB1chr7:107635332chr3:122446659ENST00000222399-5341353_13881411787.0Coiled coilOntology_term=ECO:0000255
HgeneLAMB1chr7:107635332chr3:122446659ENST00000222399-5341442_17811411787.0Coiled coilOntology_term=ECO:0000255
HgeneLAMB1chr7:107591670chr3:122446658ENST00000222399-24341132_117811301787.0DomainLaminin EGF-like 13
HgeneLAMB1chr7:107635332chr3:122446659ENST00000222399-5341028_10831411787.0DomainLaminin EGF-like 11
HgeneLAMB1chr7:107635332chr3:122446659ENST00000222399-5341084_11311411787.0DomainLaminin EGF-like 12
HgeneLAMB1chr7:107635332chr3:122446659ENST00000222399-5341132_11781411787.0DomainLaminin EGF-like 13
HgeneLAMB1chr7:107635332chr3:122446659ENST00000222399-534271_3341411787.0DomainLaminin EGF-like 1
HgeneLAMB1chr7:107635332chr3:122446659ENST00000222399-53431_2701411787.0DomainLaminin N-terminal
HgeneLAMB1chr7:107635332chr3:122446659ENST00000222399-534335_3971411787.0DomainLaminin EGF-like 2
HgeneLAMB1chr7:107635332chr3:122446659ENST00000222399-534398_4571411787.0DomainLaminin EGF-like 3
HgeneLAMB1chr7:107635332chr3:122446659ENST00000222399-534458_5091411787.0DomainLaminin EGF-like 4
HgeneLAMB1chr7:107635332chr3:122446659ENST00000222399-534510_5401411787.0DomainLaminin EGF-like 5%3B truncated
HgeneLAMB1chr7:107635332chr3:122446659ENST00000222399-534549_7671411787.0DomainLaminin IV type B
HgeneLAMB1chr7:107635332chr3:122446659ENST00000222399-534773_8201411787.0DomainLaminin EGF-like 6
HgeneLAMB1chr7:107635332chr3:122446659ENST00000222399-534821_8661411787.0DomainLaminin EGF-like 7
HgeneLAMB1chr7:107635332chr3:122446659ENST00000222399-534867_9161411787.0DomainLaminin EGF-like 8
HgeneLAMB1chr7:107635332chr3:122446659ENST00000222399-534917_9751411787.0DomainLaminin EGF-like 9
HgeneLAMB1chr7:107635332chr3:122446659ENST00000222399-534976_10271411787.0DomainLaminin EGF-like 10
HgeneLAMB1chr7:107591670chr3:122446658ENST00000222399-24341179_139711301787.0RegionNote=Domain II
HgeneLAMB1chr7:107591670chr3:122446658ENST00000222399-24341398_143011301787.0RegionNote=Domain alpha
HgeneLAMB1chr7:107591670chr3:122446658ENST00000222399-24341431_178611301787.0RegionNote=Domain I
HgeneLAMB1chr7:107635332chr3:122446659ENST00000222399-5341179_13971411787.0RegionNote=Domain II
HgeneLAMB1chr7:107635332chr3:122446659ENST00000222399-5341398_14301411787.0RegionNote=Domain alpha
HgeneLAMB1chr7:107635332chr3:122446659ENST00000222399-5341431_17861411787.0RegionNote=Domain I
TgenePARP14chr7:107591670chr3:122446658ENST0000047462914171003_119016471802.0DomainMacro 2
TgenePARP14chr7:107591670chr3:122446658ENST0000047462914171216_138716471802.0DomainMacro 3
TgenePARP14chr7:107591670chr3:122446658ENST0000047462914171523_160116471802.0DomainWWE
TgenePARP14chr7:107591670chr3:122446658ENST0000047462914171605_180116471802.0DomainPARP catalytic
TgenePARP14chr7:107591670chr3:122446658ENST000004746291417791_97816471802.0DomainMacro 1
TgenePARP14chr7:107635332chr3:122446659ENST0000047462914171003_119016471802.0DomainMacro 2
TgenePARP14chr7:107635332chr3:122446659ENST0000047462914171216_138716471802.0DomainMacro 3
TgenePARP14chr7:107635332chr3:122446659ENST0000047462914171523_160116471802.0DomainWWE
TgenePARP14chr7:107635332chr3:122446659ENST0000047462914171605_180116471802.0DomainPARP catalytic
TgenePARP14chr7:107635332chr3:122446659ENST000004746291417791_97816471802.0DomainMacro 1
TgenePARP14chr7:107591670chr3:122446658ENST0000047462914171023_102416471802.0RegionSubstrate 2 binding
TgenePARP14chr7:107591670chr3:122446658ENST0000047462914171046_104916471802.0RegionSubstrate 2 binding
TgenePARP14chr7:107591670chr3:122446658ENST0000047462914171133_113716471802.0RegionSubstrate 2 binding
TgenePARP14chr7:107591670chr3:122446658ENST0000047462914171175_117816471802.0RegionSubstrate 2 binding
TgenePARP14chr7:107591670chr3:122446658ENST0000047462914171235_123616471802.0RegionSubstrate 3 binding
TgenePARP14chr7:107591670chr3:122446658ENST0000047462914171332_133616471802.0RegionSubstrate 3 binding
TgenePARP14chr7:107591670chr3:122446658ENST000004746291417922_92616471802.0RegionSubstrate 1 binding
TgenePARP14chr7:107635332chr3:122446659ENST0000047462914171023_102416471802.0RegionSubstrate 2 binding
TgenePARP14chr7:107635332chr3:122446659ENST0000047462914171046_104916471802.0RegionSubstrate 2 binding
TgenePARP14chr7:107635332chr3:122446659ENST0000047462914171133_113716471802.0RegionSubstrate 2 binding
TgenePARP14chr7:107635332chr3:122446659ENST0000047462914171175_117816471802.0RegionSubstrate 2 binding
TgenePARP14chr7:107635332chr3:122446659ENST0000047462914171235_123616471802.0RegionSubstrate 3 binding
TgenePARP14chr7:107635332chr3:122446659ENST0000047462914171332_133616471802.0RegionSubstrate 3 binding
TgenePARP14chr7:107635332chr3:122446659ENST000004746291417922_92616471802.0RegionSubstrate 1 binding


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Fusion Gene Sequence for LAMB1-PARP14


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>43930_43930_1_LAMB1-PARP14_LAMB1_chr7_107591670_ENST00000222399_PARP14_chr3_122446658_ENST00000474629_length(transcript)=6330nt_BP=3622nt
TTGCGGCCGCCCGCCCCTTCAGCCCCGGCTCTCCGTATGCGCATGAGCAGAGGCGCCTCCCTCTGTTCCTCCCAAGGCTAAACTTTCTAA
TTCCCTTCTTTGGGCTCGGGGGCTCCCGGAGCAGGGCGAGAGCTCGCGTCGCCGGAAAGGAAGACGGGAAGAAAGGGCAGGCGGCTCGGC
GGGCGTCTTCTCCACTCCTCTGCCGCGTCCCCGTGGCTGCAGGGAGCCGGCATGGGGCTTCTCCAGTTGCTAGCTTTCAGTTTCTTAGCC
CTGTGCAGAGCCCGAGTGCGCGCTCAGGAACCCGAGTTCAGCTACGGCTGCGCAGAAGGCAGCTGCTATCCCGCCACGGGCGACCTTCTC
ATCGGCCGAGCACAGAAGCTTTCGGTGACCTCGACGTGCGGGCTGCACAAGCCCGAACCCTACTGTATCGTCAGCCACTTGCAGGAGGAC
AAAAAATGCTTCATATGCAATTCCCAAGATCCTTATCATGAGACCCTGAATCCTGACAGCCATCTCATTGAAAATGTGGTCACTACATTT
GCTCCAAACCGCCTTAAGATTTGGTGGCAATCTGAAAATGGTGTGGAAAATGTAACTATCCAACTGGATTTGGAAGCAGAATTCCATTTT
ACTCATCTCATAATGACTTTCAAGACATTCCGTCCAGCTGCTATGCTGATAGAACGATCGTCCGACTTTGGGAAAACCTGGGGTGTGTAT
AGATACTTCGCCTATGACTGTGAGGCCTCGTTTCCAGGCATTTCAACTGGCCCCATGAAAAAAGTCGATGACATAATTTGTGATTCTCGA
TATTCTGACATTGAACCCTCAACTGAAGGAGAGGTGATATTTCGTGCTTTAGATCCTGCTTTCAAAATAGAAGATCCTTATAGCCCAAGG
ATACAGAATTTATTAAAAATTACCAACTTGAGAATCAAGTTTGTGAAACTGCATACTTTGGGAGATAACCTTCTGGATTCCAGGATGGAA
ATCAGAGAAAAGTATTATTATGCAGTTTATGATATGGTGGTTCGAGGAAATTGCTTCTGCTATGGTCATGCCAGCGAATGTGCCCCTGTG
GATGGATTCAATGAAGAAGTGGAAGGAATGGTTCACGGACACTGCATGTGCAGGCATAACACCAAGGGCTTAAACTGTGAACTCTGCATG
GATTTCTACCATGATTTACCTTGGAGACCTGCTGAAGGCCGAAACAGCAACGCCTGTAAAAAATGTAACTGCAATGAACATTCCATCTCT
TGTCACTTTGACATGGCTGTTTACCTGGCCACGGGGAACGTCAGCGGAGGCGTGTGTGATGACTGTCAGCACAACACCATGGGGCGCAAC
TGTGAGCAGTGCAAGCCGTTTTACTACCAGCACCCAGAGAGGGACATCCGAGATCCTAATTTCTGTGAACGATGTACGTGTGACCCAGCT
GGCTCTCAAAATGAGGGAATTTGTGACAGCTATACTGATTTTTCTACTGGTCTCATTGCTGGCCAGTGTCGGTGTAAATTAAATGTGGAA
GGAGAACATTGTGATGTTTGCAAAGAAGGCTTCTATGATTTAAGCAGTGAAGATCCATTTGGTTGTAAATCTTGTGCTTGCAATCCTCTG
GGAACAATTCCTGGAGGGAATCCTTGTGATTCCGAGACAGGTCACTGCTACTGCAAGCGTCTGGTGACAGGACAGCATTGTGACCAGTGC
CTGCCAGAGCACTGGGGCTTAAGCAATGATTTGGATGGATGTCGACCATGTGACTGTGACCTTGGGGGAGCCTTAAACAACAGTTGCTTT
GCGGAGTCAGGCCAGTGCTCATGCCGGCCTCACATGATTGGACGTCAGTGCAACGAAGTGGAACCTGGTTACTACTTTGCCACCCTGGAT
CACTACCTCTATGAAGCGGAGGAAGCCAACTTGGGGCCTGGGGTTAGCATAGTGGAGCGGCAATATATCCAGGACCGGATTCCCTCCTGG
ACTGGAGCCGGCTTCGTCCGAGTGCCTGAAGGGGCTTATTTGGAGTTTTTCATTGACAACATACCATATTCCATGGAGTACGACATCCTA
ATTCGCTACGAGCCACAGCTACCCGACCACTGGGAAAAAGCTGTCATCACAGTGCAGCGACCTGGAAGGATTCCAACCAGCAGCCGATGT
GGTAATACCATCCCCGATGATGACAACCAGGTGGTGTCATTATCACCAGGCTCAAGATATGTCGTCCTTCCTCGGCCGGTGTGCTTTGAG
AAGGGAACAAACTACACGGTGAGGTTGGAGCTGCCTCAGTACACCTCCTCTGATAGCGACGTGGAGAGCCCCTACACGCTGATCGATTCT
CTTGTTCTCATGCCATACTGTAAATCACTGGACATCTTCACCGTGGGAGGTTCAGGAGATGGGGTGGTCACCAACAGTGCCTGGGAAACC
TTTCAGAGATACCGATGTCTAGAGAACAGCAGAAGCGTTGTGAAAACACCGATGACAGATGTTTGCAGAAACATCATCTTTAGCATTTCT
GCCCTGTTACACCAGACAGGCCTGGCTTGTGAATGCGACCCTCAGGGTTCGTTAAGTTCCGTGTGTGATCCCAACGGAGGCCAGTGCCAG
TGCCGGCCCAACGTGGTTGGAAGAACCTGCAACAGATGTGCACCTGGAACTTTTGGCTTTGGCCCCAGTGGATGCAAACCTTGTGAGTGC
CATCTGCAAGGATCTGTCAATGCCTTCTGCAATCCCGTCACTGGCCAGTGCCACTGTTTCCAGGGAGTGTATGCTCGGCAGTGTGATCGG
TGCTTACCTGGGCACTGGGGCTTTCCAAGTTGCCAGCCCTGCCAGTGCAATGGCCACGCCGATGACTGCGACCCAGTGACTGGGGAGTGC
TTGAACTGCCAGGACTACACCATGGGTCATAACTGTGAAAGGTGCTTGGCTGGTTACTATGGCGACCCCATCATTGGGTCAGGAGATCAC
TGCCGCCCTTGCCCTTGCCCAGATGGTCCCGACAGTGGACGCCAGTTTGCCAGGAGCTGCTACCAAGATCCTGTTACTTTACAGCTTGCC
TGTGTTTGTGATCCTGGATACATTGGTTCCAGATGTGACGACTGTGCCTCAGGATACTTTGGCAATCCATCAGAAGTTGGGGGGTCGTGT
CAGCCTTGCCAGTGTCACAACAACATTGACACGACAGACCCAGAAGCCTGTGACAAGGAGACTGGGAGGTGTCTCAAGTGCCTGTACCAC
ACGGAAGGGGAACACTGTCAGTTCTGCCGGTTTGGATACTATGGTGATGCCCTCCAGCAGGACTGTCGAAAGTGTGTCTGTAATTACCTG
GGCACCGTGCAAGAGCACTGTAACGGCTCTGACTGCCAGTGCGACAAAGCCACTGGTCAGTGCTTGTGTCTTCCTAATGTGATCGGGCAG
AACTGTGACCGCTGTGCGCCCAATACCTGGCAGCTGGCCAGTGGCACTGGCTGTGACCCATGCAACTGCAATGCTGCTCATTCCTTCGGG
CCATCTTGCAATGAGTTCACGGGGCAGTGCCAGTGCATGCCTGGGTTTGGAGGCCGCACCTGCAGCGAGTGCCAGGAACTCTTCTGGGGA
GACCCCGACGTGGAGTGCCGAGATTGAGAGGATCCAGAATCCAGATCTCTGGAATAGCTACCAGGCAAAGAAAAAAACTATGGATGCCAA
GAATGGCCAGACAATGAATGAGAAGCAACTCTTCCATGGGACAGATGCCGGCTCCGTGCCACACGTCAATCGAAATGGCTTTAACCGCAG
CTATGCCGGAAAGAATGCTGTGGCATATGGAAAGGGAACCTATTTTGCTGTCAATGCCAATTATTCTGCCAATGATACGTACTCCAGACC
AGATGCAAATGGGAGAAAGCATGTGTATTATGTGCGAGTACTTACTGGAATCTATACACATGGAAATCATTCATTAATTGTGCCTCCTTC
AAAGAACCCTCAAAATCCTACTGACCTGTATGACACTGTCACAGATAATGTGCACCATCCAAGTTTATTTGTGGCATTTTATGACTACCA
AGCATACCCAGAGTACCTTATTACGTTTAGAAAATAACACTTTGGTATCCTTCCCACAAAATTATTCTCCATTTGTACATATCTAGTTGT
AAAACAAGTTTTAGCTTTTTTTTTTAATTCCTCTTAACAGATTTTTCTAATATCCAAGGATCATTCTTTGTCGCTGAAGTCAGTCTTTCT
TCAGCTTCCCTTTCATAATGGAAATGAACTTATTATCTTGAGAGCAAATAACTTGGAAAATTTAAATGAGATAATGCAGTTGCAACTGTG
TGTCCACAAGTATGGACATCAAATCTGTGGGAAAAGAACAGGTTTGTATTTTCAGGAAGGAGAGAATAACAGTCTTATAGACAGAGGGCA
CAGCTAAGCACAGCTGCCACTGCAGGAGACAGGCCCCATGTCAGGATGCCATAGTGCTGTGGGGAGCACAGTATTACCCAGTGGGTAGGG
CTTCTGTCTTCCCTGGGAGCAGGGATGGTATCTTAGTCAATTTTTTTCCCTTGAGATGAGGTCTGTGCCTGATGTACAACGGATACTCCA
TAAATGTTTGACAAACCAACGAAGAATGAAAAAAAGCCTAGTCAGACTCCCATCCAAAGTAGGAACTATCTCTTTAACATTCTTGACTCA
CTATCACTTTACCTCAAATTGAACAGATTCCATGACGGAACTTCATTCTTCACAAACTAGCCAGTGACATGTGGGACAGCTCTGGCCAGG
GCTCTGGGACTGCAGTGTACTTGCGCTCTGCACGGTCCAGGAGCTGTGATGTGGCTGTGGTCTAGGGGAATCCTGCCTGCCCCATGGAGT
TGCGCAGCACAACCCTGGCTCCAATTGCCAGAAGGCTCTTTTTAATGCTGAACCAAAATGTGCCTTTTTTTTTTTTTTTTTGAGATGGAG
TTTCACTCTTGTTGCCCAGGCTGGAGTGCAATGGCGCGATCTCAGCTCACTGCAGCCACTGCCTCCCAGGTTCAAGTGATTCTCCTGCCT
CAGCCTCCCGAGTAGCTGGGATTACAGGCATGCGCTAACACACCCAGCTAATTTTGTATTTTTAGTAGAGACGAGGTTTCTCCATGTTCG
ACAGGCTGGTCTCGAACTCCCACCTCAGCCTCCCAAACTGCTGGGATTACAGGTGTGAGCCACCGTGACCAGCCAATGTGCCTTCTTATA
GTGTCTACTCATTGGTCTTTGTTCTGCCCAGTGATAACAATGGGATAACGCCTGCTACACATCTTCATTGTGAAACCCTTCCCCTGTGCT
GAGATTAAATGAACTCTAAGATTATTAAATAGTATATTTTCCTTGACAGCCTAGCGTTTGATGATTTTAAAGCCTTATGTATAAATAAAC
CAAAGGAAGTAAGCAGTCATATTGCTAATTTGCTAACTCCTATCTATTGAATGGTGAAGTTTTAAAAATTTCCCCAGGTAAGTTTAAGAT
TCAAACACCATCTATTGAGCACCTACATTGTGTGCCAGGTAGTAAAATAGGTGCTTTCATACACATTGTCTCAATTCCTGTGAGGTCAGA
ATTATCTCTGCATTTGAAACTTGAGGAAACATGCTCAGAGTGCAAGAAGCTTCCTTGCCTGAGATCACCTAGAAAGGAACCCTCAGAGCC
GGCAACTGAATCTTGGTCCCTGTGATGTCAAGCCCATTGCTCTCCCACTGCAGAACATGGCCTCTAGATTAATGCCACCGATTCAGGAAC
ACCTCCGACAGTCTTGAAATACCCCCATGTTGCCTTGTTTGTTTTTTCCTTCTGGCTTCTTCTATTACAGTCTCTTCATTGGAAGCTCTG
TAGGCCAAGGCCAGAGCTGATACTGACACGGAGCCAATGCAGATAGCACATCAGATGCTAGGGGTCGCTGGGAGGATTAAGGGACTTAAT
CTGCTAGGAACACCTGTACTTGAAGTGGAGGAGGCTAGGGGGCCACAGTTGCTGCTTCATTAACATAGAGGTTTTGGATTTTTTTCTCTT
GTGGTTTGTTTTTTAAGTGGATTGGCAGACTCCTTGTTGCTTAAGAGTGGCTTTCTAGGCAGGCCACTGGCATCTGAATTCATCATTGAC
AATAAATGTAAGAAATTGGAATAAAAAAGAGAGACCTGCTGTTATTCGCTTTTGTTCTCCAGTGATTTGATTAACTCAGGGCAAGGCTGA
ATATCAGAGTGTATCGCACTGAAGAATAATAATCCATTCAGTAATGTTATAGTTATCCTCAATCTAAATATGTCAACTGTCATTTTGCTA

>43930_43930_1_LAMB1-PARP14_LAMB1_chr7_107591670_ENST00000222399_PARP14_chr3_122446658_ENST00000474629_length(amino acids)=1175AA_BP=
MGSGAPGAGRELASPERKTGRKGRRLGGRLLHSSAASPWLQGAGMGLLQLLAFSFLALCRARVRAQEPEFSYGCAEGSCYPATGDLLIGR
AQKLSVTSTCGLHKPEPYCIVSHLQEDKKCFICNSQDPYHETLNPDSHLIENVVTTFAPNRLKIWWQSENGVENVTIQLDLEAEFHFTHL
IMTFKTFRPAAMLIERSSDFGKTWGVYRYFAYDCEASFPGISTGPMKKVDDIICDSRYSDIEPSTEGEVIFRALDPAFKIEDPYSPRIQN
LLKITNLRIKFVKLHTLGDNLLDSRMEIREKYYYAVYDMVVRGNCFCYGHASECAPVDGFNEEVEGMVHGHCMCRHNTKGLNCELCMDFY
HDLPWRPAEGRNSNACKKCNCNEHSISCHFDMAVYLATGNVSGGVCDDCQHNTMGRNCEQCKPFYYQHPERDIRDPNFCERCTCDPAGSQ
NEGICDSYTDFSTGLIAGQCRCKLNVEGEHCDVCKEGFYDLSSEDPFGCKSCACNPLGTIPGGNPCDSETGHCYCKRLVTGQHCDQCLPE
HWGLSNDLDGCRPCDCDLGGALNNSCFAESGQCSCRPHMIGRQCNEVEPGYYFATLDHYLYEAEEANLGPGVSIVERQYIQDRIPSWTGA
GFVRVPEGAYLEFFIDNIPYSMEYDILIRYEPQLPDHWEKAVITVQRPGRIPTSSRCGNTIPDDDNQVVSLSPGSRYVVLPRPVCFEKGT
NYTVRLELPQYTSSDSDVESPYTLIDSLVLMPYCKSLDIFTVGGSGDGVVTNSAWETFQRYRCLENSRSVVKTPMTDVCRNIIFSISALL
HQTGLACECDPQGSLSSVCDPNGGQCQCRPNVVGRTCNRCAPGTFGFGPSGCKPCECHLQGSVNAFCNPVTGQCHCFQGVYARQCDRCLP
GHWGFPSCQPCQCNGHADDCDPVTGECLNCQDYTMGHNCERCLAGYYGDPIIGSGDHCRPCPCPDGPDSGRQFARSCYQDPVTLQLACVC
DPGYIGSRCDDCASGYFGNPSEVGGSCQPCQCHNNIDTTDPEACDKETGRCLKCLYHTEGEHCQFCRFGYYGDALQQDCRKCVCNYLGTV
QEHCNGSDCQCDKATGQCLCLPNVIGQNCDRCAPNTWQLASGTGCDPCNCNAAHSFGPSCNEFTGQCQCMPGFGGRTCSECQELFWGDPD

--------------------------------------------------------------
>43930_43930_2_LAMB1-PARP14_LAMB1_chr7_107635332_ENST00000393561_PARP14_chr3_122446659_ENST00000474629_length(transcript)=3388nt_BP=680nt
GGGGCTGATCAGGGTGGGCGCGAGCGTCGGTGGGTTTCCCGGGAGGGAGGCTCTCGCTGCTGGACAGACCTGATGACGTGTGTGGGTTTC
TTTCCGTGTCCTTCTCCTTTCGGAGTCCCTGCCTTCCCAGCCTCTCCTGCGCTCATCTCTCCATTGTCTTTTCTGTGCATTTTGCTTTCT
TCCGAATGGACTGTCCTCTCTCCGCACCCACTCCCCCGCCCCCGCTTGTTCGTTTTTTTCGGGCTCCACTCCCTGCTTGTGTCCCCCCAA
CTCTGTTGCCTGTCCTTCCCGCAGCCCTGTGCAGAGCCCGAGTGCGCGCTCAGGAACCCGAGTTCAGCTACGGCTGCGCAGAAGGCAGCT
GCTATCCCGCCACGGGCGACCTTCTCATCGGCCGAGCACAGAAGCTTTCGGTGACCTCGACGTGCGGGCTGCACAAGCCCGAACCCTACT
GTATCGTCAGCCACTTGCAGGAGGACAAAAAATGCTTCATATGCAATTCCCAAGATCCTTATCATGAGACCCTGAATCCTGACAGCCATC
TCATTGAAAATGTGGTCACTACATTTGCTCCAAACCGCCTTAAGATTTGGTGGCAATCTGAAAATGGTGTGGAAAATGTAACTATCCAAC
TGGATTTGGAAGCAGAATTCCATTTTACTCATCTCATAATGACTTTCAAGATTGAGAGGATCCAGAATCCAGATCTCTGGAATAGCTACC
AGGCAAAGAAAAAAACTATGGATGCCAAGAATGGCCAGACAATGAATGAGAAGCAACTCTTCCATGGGACAGATGCCGGCTCCGTGCCAC
ACGTCAATCGAAATGGCTTTAACCGCAGCTATGCCGGAAAGAATGCTGTGGCATATGGAAAGGGAACCTATTTTGCTGTCAATGCCAATT
ATTCTGCCAATGATACGTACTCCAGACCAGATGCAAATGGGAGAAAGCATGTGTATTATGTGCGAGTACTTACTGGAATCTATACACATG
GAAATCATTCATTAATTGTGCCTCCTTCAAAGAACCCTCAAAATCCTACTGACCTGTATGACACTGTCACAGATAATGTGCACCATCCAA
GTTTATTTGTGGCATTTTATGACTACCAAGCATACCCAGAGTACCTTATTACGTTTAGAAAATAACACTTTGGTATCCTTCCCACAAAAT
TATTCTCCATTTGTACATATCTAGTTGTAAAACAAGTTTTAGCTTTTTTTTTTAATTCCTCTTAACAGATTTTTCTAATATCCAAGGATC
ATTCTTTGTCGCTGAAGTCAGTCTTTCTTCAGCTTCCCTTTCATAATGGAAATGAACTTATTATCTTGAGAGCAAATAACTTGGAAAATT
TAAATGAGATAATGCAGTTGCAACTGTGTGTCCACAAGTATGGACATCAAATCTGTGGGAAAAGAACAGGTTTGTATTTTCAGGAAGGAG
AGAATAACAGTCTTATAGACAGAGGGCACAGCTAAGCACAGCTGCCACTGCAGGAGACAGGCCCCATGTCAGGATGCCATAGTGCTGTGG
GGAGCACAGTATTACCCAGTGGGTAGGGCTTCTGTCTTCCCTGGGAGCAGGGATGGTATCTTAGTCAATTTTTTTCCCTTGAGATGAGGT
CTGTGCCTGATGTACAACGGATACTCCATAAATGTTTGACAAACCAACGAAGAATGAAAAAAAGCCTAGTCAGACTCCCATCCAAAGTAG
GAACTATCTCTTTAACATTCTTGACTCACTATCACTTTACCTCAAATTGAACAGATTCCATGACGGAACTTCATTCTTCACAAACTAGCC
AGTGACATGTGGGACAGCTCTGGCCAGGGCTCTGGGACTGCAGTGTACTTGCGCTCTGCACGGTCCAGGAGCTGTGATGTGGCTGTGGTC
TAGGGGAATCCTGCCTGCCCCATGGAGTTGCGCAGCACAACCCTGGCTCCAATTGCCAGAAGGCTCTTTTTAATGCTGAACCAAAATGTG
CCTTTTTTTTTTTTTTTTTGAGATGGAGTTTCACTCTTGTTGCCCAGGCTGGAGTGCAATGGCGCGATCTCAGCTCACTGCAGCCACTGC
CTCCCAGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGCATGCGCTAACACACCCAGCTAATTTTGTATTTT
TAGTAGAGACGAGGTTTCTCCATGTTCGACAGGCTGGTCTCGAACTCCCACCTCAGCCTCCCAAACTGCTGGGATTACAGGTGTGAGCCA
CCGTGACCAGCCAATGTGCCTTCTTATAGTGTCTACTCATTGGTCTTTGTTCTGCCCAGTGATAACAATGGGATAACGCCTGCTACACAT
CTTCATTGTGAAACCCTTCCCCTGTGCTGAGATTAAATGAACTCTAAGATTATTAAATAGTATATTTTCCTTGACAGCCTAGCGTTTGAT
GATTTTAAAGCCTTATGTATAAATAAACCAAAGGAAGTAAGCAGTCATATTGCTAATTTGCTAACTCCTATCTATTGAATGGTGAAGTTT
TAAAAATTTCCCCAGGTAAGTTTAAGATTCAAACACCATCTATTGAGCACCTACATTGTGTGCCAGGTAGTAAAATAGGTGCTTTCATAC
ACATTGTCTCAATTCCTGTGAGGTCAGAATTATCTCTGCATTTGAAACTTGAGGAAACATGCTCAGAGTGCAAGAAGCTTCCTTGCCTGA
GATCACCTAGAAAGGAACCCTCAGAGCCGGCAACTGAATCTTGGTCCCTGTGATGTCAAGCCCATTGCTCTCCCACTGCAGAACATGGCC
TCTAGATTAATGCCACCGATTCAGGAACACCTCCGACAGTCTTGAAATACCCCCATGTTGCCTTGTTTGTTTTTTCCTTCTGGCTTCTTC
TATTACAGTCTCTTCATTGGAAGCTCTGTAGGCCAAGGCCAGAGCTGATACTGACACGGAGCCAATGCAGATAGCACATCAGATGCTAGG
GGTCGCTGGGAGGATTAAGGGACTTAATCTGCTAGGAACACCTGTACTTGAAGTGGAGGAGGCTAGGGGGCCACAGTTGCTGCTTCATTA
ACATAGAGGTTTTGGATTTTTTTCTCTTGTGGTTTGTTTTTTAAGTGGATTGGCAGACTCCTTGTTGCTTAAGAGTGGCTTTCTAGGCAG
GCCACTGGCATCTGAATTCATCATTGACAATAAATGTAAGAAATTGGAATAAAAAAGAGAGACCTGCTGTTATTCGCTTTTGTTCTCCAG
TGATTTGATTAACTCAGGGCAAGGCTGAATATCAGAGTGTATCGCACTGAAGAATAATAATCCATTCAGTAATGTTATAGTTATCCTCAA

>43930_43930_2_LAMB1-PARP14_LAMB1_chr7_107635332_ENST00000393561_PARP14_chr3_122446659_ENST00000474629_length(amino acids)=362AA_BP=208
MLDRPDDVCGFLSVSFSFRSPCLPSLSCAHLSIVFSVHFAFFRMDCPLSAPTPPPPLVRFFRAPLPACVPPTLLPVLPAALCRARVRAQE
PEFSYGCAEGSCYPATGDLLIGRAQKLSVTSTCGLHKPEPYCIVSHLQEDKKCFICNSQDPYHETLNPDSHLIENVVTTFAPNRLKIWWQ
SENGVENVTIQLDLEAEFHFTHLIMTFKIERIQNPDLWNSYQAKKKTMDAKNGQTMNEKQLFHGTDAGSVPHVNRNGFNRSYAGKNAVAY
GKGTYFAVNANYSANDTYSRPDANGRKHVYYVRVLTGIYTHGNHSLIVPPSKNPQNPTDLYDTVTDNVHHPSLFVAFYDYQAYPEYLITF

--------------------------------------------------------------

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Fusion Gene PPI Analysis for LAMB1-PARP14


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for LAMB1-PARP14


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for LAMB1-PARP14


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource