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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:LAMB3-ASPM (FusionGDB2 ID:43942)

Fusion Gene Summary for LAMB3-ASPM

check button Fusion gene summary
Fusion gene informationFusion gene name: LAMB3-ASPM
Fusion gene ID: 43942
HgeneTgene
Gene symbol

LAMB3

ASPM

Gene ID

3914

259266

Gene namelaminin subunit beta 3assembly factor for spindle microtubules
SynonymsAI1A|BM600-125KDA|LAM5|LAMNB1ASP|Calmbp1|MCPH5
Cytomap

1q32.2

1q31.3

Type of geneprotein-codingprotein-coding
Descriptionlaminin subunit beta-3epiligrin subunit batakalinin B1 chainkalinin subunit betakalinin-140kDalaminin B1k chainlaminin S B3 chainlaminin beta 3laminin, beta 3 (nicein (125kD), kalinin (140kD), BM600 (125kD))laminin-5 subunit betanicein subunit babnormal spindle-like microcephaly-associated proteinabnormal spindle microtubule assemblyasp (abnormal spindle) homolog, microcephaly associated
Modification date2020031320200328
UniProtAcc

Q13751

Q8IZT6

Ensembl transtripts involved in fusion geneENST00000356082, ENST00000367030, 
ENST00000391911, 		ENST00000294732, 
ENST00000367408, ENST00000367409, 
Fusion gene scores* DoF score10 X 10 X 3=3006 X 6 X 3=108
# samples 116
** MAII scorelog2(11/300*10)=-1.44745897697122
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/108*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: LAMB3 [Title/Abstract] AND ASPM [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointLAMB3(209811253)-ASPM(197056102), # samples:1
Anticipated loss of major functional domain due to fusion event.LAMB3-ASPM seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
LAMB3-ASPM seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across LAMB3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ASPM (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-HU-A4GN-01ALAMB3chr1

209811253

-ASPMchr1

197056102

-


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Fusion Gene ORF analysis for LAMB3-ASPM

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000356082ENST00000294732LAMB3chr1

209811253

-ASPMchr1

197056102

-
Frame-shiftENST00000356082ENST00000367408LAMB3chr1

209811253

-ASPMchr1

197056102

-
Frame-shiftENST00000356082ENST00000367409LAMB3chr1

209811253

-ASPMchr1

197056102

-
Frame-shiftENST00000367030ENST00000294732LAMB3chr1

209811253

-ASPMchr1

197056102

-
Frame-shiftENST00000367030ENST00000367408LAMB3chr1

209811253

-ASPMchr1

197056102

-
Frame-shiftENST00000367030ENST00000367409LAMB3chr1

209811253

-ASPMchr1

197056102

-
In-frameENST00000391911ENST00000294732LAMB3chr1

209811253

-ASPMchr1

197056102

-
In-frameENST00000391911ENST00000367408LAMB3chr1

209811253

-ASPMchr1

197056102

-
In-frameENST00000391911ENST00000367409LAMB3chr1

209811253

-ASPMchr1

197056102

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000391911LAMB3chr1209811253-ENST00000294732ASPMchr1197056102-12317623151034239
ENST00000391911LAMB3chr1209811253-ENST00000367409ASPMchr1197056102-12317623151034239
ENST00000391911LAMB3chr1209811253-ENST00000367408ASPMchr1197056102-12277623151034239

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000391911ENST00000294732LAMB3chr1209811253-ASPMchr1197056102-0.0014982930.9985018
ENST00000391911ENST00000367409LAMB3chr1209811253-ASPMchr1197056102-0.0014982930.9985018
ENST00000391911ENST00000367408LAMB3chr1209811253-ASPMchr1197056102-0.0015077880.99849224

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Fusion Genomic Features for LAMB3-ASPM


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for LAMB3-ASPM


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:209811253/chr1:197056102)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LAMB3

Q13751

ASPM

Q8IZT6

FUNCTION: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.FUNCTION: Involved in mitotic spindle regulation and coordination of mitotic processes. The function in regulating microtubule dynamics at spindle poles including spindle orientation, astral microtubule density and poleward microtubule flux seems to depend on the association with the katanin complex formed by KATNA1 and KATNB1. Enhances the microtubule lattice severing activity of KATNA1 by recruiting the katanin complex to microtubules. Can block microtubule minus-end growth and reversely this function can be enhanced by the katanin complex (PubMed:28436967). May have a preferential role in regulating neurogenesis. {ECO:0000269|PubMed:12355089, ECO:0000269|PubMed:15972725, ECO:0000269|PubMed:28436967}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneASPMchr1:209811253chr1:197056102ENST0000029473224271801_183018021893.0DomainIQ 8
TgeneASPMchr1:209811253chr1:197056102ENST0000029473224271824_185318021893.0DomainIQ 9
TgeneASPMchr1:209811253chr1:197056102ENST0000029473224271874_190318021893.0DomainIQ 10
TgeneASPMchr1:209811253chr1:197056102ENST0000029473224271897_192818021893.0DomainIQ 11
TgeneASPMchr1:209811253chr1:197056102ENST0000029473224271947_197818021893.0DomainIQ 12
TgeneASPMchr1:209811253chr1:197056102ENST0000029473224271970_200118021893.0DomainIQ 13
TgeneASPMchr1:209811253chr1:197056102ENST0000029473224272020_204918021893.0DomainIQ 14
TgeneASPMchr1:209811253chr1:197056102ENST0000029473224272043_207418021893.0DomainIQ 15
TgeneASPMchr1:209811253chr1:197056102ENST0000029473224272093_212418021893.0DomainIQ 16
TgeneASPMchr1:209811253chr1:197056102ENST0000029473224272116_214718021893.0DomainIQ 17
TgeneASPMchr1:209811253chr1:197056102ENST0000029473224272166_219718021893.0DomainIQ 18
TgeneASPMchr1:209811253chr1:197056102ENST0000029473224272189_221818021893.0DomainIQ 19
TgeneASPMchr1:209811253chr1:197056102ENST0000029473224272239_227018021893.0DomainIQ 20
TgeneASPMchr1:209811253chr1:197056102ENST0000029473224272262_229318021893.0DomainIQ 21
TgeneASPMchr1:209811253chr1:197056102ENST0000029473224272311_234218021893.0DomainIQ 22
TgeneASPMchr1:209811253chr1:197056102ENST0000029473224272334_236518021893.0DomainIQ 23
TgeneASPMchr1:209811253chr1:197056102ENST0000029473224272384_241518021893.0DomainIQ 24
TgeneASPMchr1:209811253chr1:197056102ENST0000029473224272407_243818021893.0DomainIQ 25
TgeneASPMchr1:209811253chr1:197056102ENST0000029473224272457_248818021893.0DomainIQ 26
TgeneASPMchr1:209811253chr1:197056102ENST0000029473224272530_256118021893.0DomainIQ 27
TgeneASPMchr1:209811253chr1:197056102ENST0000029473224272624_265318021893.0DomainIQ 28
TgeneASPMchr1:209811253chr1:197056102ENST0000029473224272665_269618021893.0DomainIQ 29
TgeneASPMchr1:209811253chr1:197056102ENST0000029473224272688_271918021893.0DomainIQ 30
TgeneASPMchr1:209811253chr1:197056102ENST0000029473224272738_276718021893.0DomainIQ 31
TgeneASPMchr1:209811253chr1:197056102ENST0000029473224272859_289018021893.0DomainIQ 32
TgeneASPMchr1:209811253chr1:197056102ENST0000029473224272909_293818021893.0DomainIQ 33
TgeneASPMchr1:209811253chr1:197056102ENST0000029473224272932_296318021893.0DomainIQ 34
TgeneASPMchr1:209811253chr1:197056102ENST0000029473224272954_298518021893.0DomainIQ 35
TgeneASPMchr1:209811253chr1:197056102ENST0000029473224273029_306018021893.0DomainIQ 36
TgeneASPMchr1:209811253chr1:197056102ENST0000029473224273079_311018021893.0DomainIQ 37
TgeneASPMchr1:209811253chr1:197056102ENST0000029473224273181_321018021893.0DomainIQ 38
TgeneASPMchr1:209811253chr1:197056102ENST0000029473224273204_323518021893.0DomainIQ 39

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLAMB3chr1:209811253chr1:197056102ENST00000356082-523723_7571241173.0Coiled coilOntology_term=ECO:0000255
HgeneLAMB3chr1:209811253chr1:197056102ENST00000356082-523831_8841241173.0Coiled coilOntology_term=ECO:0000255
HgeneLAMB3chr1:209811253chr1:197056102ENST00000356082-523948_11331241173.0Coiled coilOntology_term=ECO:0000255
HgeneLAMB3chr1:209811253chr1:197056102ENST00000367030-523723_7571241173.0Coiled coilOntology_term=ECO:0000255
HgeneLAMB3chr1:209811253chr1:197056102ENST00000367030-523831_8841241173.0Coiled coilOntology_term=ECO:0000255
HgeneLAMB3chr1:209811253chr1:197056102ENST00000367030-523948_11331241173.0Coiled coilOntology_term=ECO:0000255
HgeneLAMB3chr1:209811253chr1:197056102ENST00000391911-422723_7571241173.0Coiled coilOntology_term=ECO:0000255
HgeneLAMB3chr1:209811253chr1:197056102ENST00000391911-422831_8841241173.0Coiled coilOntology_term=ECO:0000255
HgeneLAMB3chr1:209811253chr1:197056102ENST00000391911-422948_11331241173.0Coiled coilOntology_term=ECO:0000255
HgeneLAMB3chr1:209811253chr1:197056102ENST00000356082-52322_2491241173.0DomainLaminin N-terminal
HgeneLAMB3chr1:209811253chr1:197056102ENST00000356082-523250_3151241173.0DomainLaminin EGF-like 1
HgeneLAMB3chr1:209811253chr1:197056102ENST00000356082-523316_3781241173.0DomainLaminin EGF-like 2
HgeneLAMB3chr1:209811253chr1:197056102ENST00000356082-523379_4301241173.0DomainLaminin EGF-like 3
HgeneLAMB3chr1:209811253chr1:197056102ENST00000356082-523431_4801241173.0DomainLaminin EGF-like 4
HgeneLAMB3chr1:209811253chr1:197056102ENST00000356082-523481_5331241173.0DomainLaminin EGF-like 5
HgeneLAMB3chr1:209811253chr1:197056102ENST00000356082-523534_5801241173.0DomainLaminin EGF-like 6
HgeneLAMB3chr1:209811253chr1:197056102ENST00000367030-52322_2491241173.0DomainLaminin N-terminal
HgeneLAMB3chr1:209811253chr1:197056102ENST00000367030-523250_3151241173.0DomainLaminin EGF-like 1
HgeneLAMB3chr1:209811253chr1:197056102ENST00000367030-523316_3781241173.0DomainLaminin EGF-like 2
HgeneLAMB3chr1:209811253chr1:197056102ENST00000367030-523379_4301241173.0DomainLaminin EGF-like 3
HgeneLAMB3chr1:209811253chr1:197056102ENST00000367030-523431_4801241173.0DomainLaminin EGF-like 4
HgeneLAMB3chr1:209811253chr1:197056102ENST00000367030-523481_5331241173.0DomainLaminin EGF-like 5
HgeneLAMB3chr1:209811253chr1:197056102ENST00000367030-523534_5801241173.0DomainLaminin EGF-like 6
HgeneLAMB3chr1:209811253chr1:197056102ENST00000391911-42222_2491241173.0DomainLaminin N-terminal
HgeneLAMB3chr1:209811253chr1:197056102ENST00000391911-422250_3151241173.0DomainLaminin EGF-like 1
HgeneLAMB3chr1:209811253chr1:197056102ENST00000391911-422316_3781241173.0DomainLaminin EGF-like 2
HgeneLAMB3chr1:209811253chr1:197056102ENST00000391911-422379_4301241173.0DomainLaminin EGF-like 3
HgeneLAMB3chr1:209811253chr1:197056102ENST00000391911-422431_4801241173.0DomainLaminin EGF-like 4
HgeneLAMB3chr1:209811253chr1:197056102ENST00000391911-422481_5331241173.0DomainLaminin EGF-like 5
HgeneLAMB3chr1:209811253chr1:197056102ENST00000391911-422534_5801241173.0DomainLaminin EGF-like 6
HgeneLAMB3chr1:209811253chr1:197056102ENST00000356082-523579_7851241173.0RegionNote=Domain II
HgeneLAMB3chr1:209811253chr1:197056102ENST00000356082-523786_8161241173.0RegionNote=Domain alpha
HgeneLAMB3chr1:209811253chr1:197056102ENST00000356082-523817_11701241173.0RegionNote=Domain I
HgeneLAMB3chr1:209811253chr1:197056102ENST00000367030-523579_7851241173.0RegionNote=Domain II
HgeneLAMB3chr1:209811253chr1:197056102ENST00000367030-523786_8161241173.0RegionNote=Domain alpha
HgeneLAMB3chr1:209811253chr1:197056102ENST00000367030-523817_11701241173.0RegionNote=Domain I
HgeneLAMB3chr1:209811253chr1:197056102ENST00000391911-422579_7851241173.0RegionNote=Domain II
HgeneLAMB3chr1:209811253chr1:197056102ENST00000391911-422786_8161241173.0RegionNote=Domain alpha
HgeneLAMB3chr1:209811253chr1:197056102ENST00000391911-422817_11701241173.0RegionNote=Domain I
TgeneASPMchr1:209811253chr1:197056102ENST0000029473224271057_107818021893.0Coiled coilOntology_term=ECO:0000255
TgeneASPMchr1:209811253chr1:197056102ENST0000036740925281057_107833873478.0Coiled coilOntology_term=ECO:0000255
TgeneASPMchr1:209811253chr1:197056102ENST0000029473224271110_126118021893.0DomainCalponin-homology (CH) 2
TgeneASPMchr1:209811253chr1:197056102ENST0000029473224271347_137818021893.0DomainIQ 1
TgeneASPMchr1:209811253chr1:197056102ENST0000029473224271393_142218021893.0DomainIQ 2
TgeneASPMchr1:209811253chr1:197056102ENST0000029473224271582_161318021893.0DomainIQ 3
TgeneASPMchr1:209811253chr1:197056102ENST0000029473224271632_166118021893.0DomainIQ 4
TgeneASPMchr1:209811253chr1:197056102ENST0000029473224271655_168418021893.0DomainIQ 5
TgeneASPMchr1:209811253chr1:197056102ENST0000029473224271728_175718021893.0DomainIQ 6
TgeneASPMchr1:209811253chr1:197056102ENST0000029473224271751_178218021893.0DomainIQ 7
TgeneASPMchr1:209811253chr1:197056102ENST000002947322427920_105618021893.0DomainCalponin-homology (CH) 1
TgeneASPMchr1:209811253chr1:197056102ENST0000036740925281110_126133873478.0DomainCalponin-homology (CH) 2
TgeneASPMchr1:209811253chr1:197056102ENST0000036740925281347_137833873478.0DomainIQ 1
TgeneASPMchr1:209811253chr1:197056102ENST0000036740925281393_142233873478.0DomainIQ 2
TgeneASPMchr1:209811253chr1:197056102ENST0000036740925281582_161333873478.0DomainIQ 3
TgeneASPMchr1:209811253chr1:197056102ENST0000036740925281632_166133873478.0DomainIQ 4
TgeneASPMchr1:209811253chr1:197056102ENST0000036740925281655_168433873478.0DomainIQ 5
TgeneASPMchr1:209811253chr1:197056102ENST0000036740925281728_175733873478.0DomainIQ 6
TgeneASPMchr1:209811253chr1:197056102ENST0000036740925281751_178233873478.0DomainIQ 7
TgeneASPMchr1:209811253chr1:197056102ENST0000036740925281801_183033873478.0DomainIQ 8
TgeneASPMchr1:209811253chr1:197056102ENST0000036740925281824_185333873478.0DomainIQ 9
TgeneASPMchr1:209811253chr1:197056102ENST0000036740925281874_190333873478.0DomainIQ 10
TgeneASPMchr1:209811253chr1:197056102ENST0000036740925281897_192833873478.0DomainIQ 11
TgeneASPMchr1:209811253chr1:197056102ENST0000036740925281947_197833873478.0DomainIQ 12
TgeneASPMchr1:209811253chr1:197056102ENST0000036740925281970_200133873478.0DomainIQ 13
TgeneASPMchr1:209811253chr1:197056102ENST0000036740925282020_204933873478.0DomainIQ 14
TgeneASPMchr1:209811253chr1:197056102ENST0000036740925282043_207433873478.0DomainIQ 15
TgeneASPMchr1:209811253chr1:197056102ENST0000036740925282093_212433873478.0DomainIQ 16
TgeneASPMchr1:209811253chr1:197056102ENST0000036740925282116_214733873478.0DomainIQ 17
TgeneASPMchr1:209811253chr1:197056102ENST0000036740925282166_219733873478.0DomainIQ 18
TgeneASPMchr1:209811253chr1:197056102ENST0000036740925282189_221833873478.0DomainIQ 19
TgeneASPMchr1:209811253chr1:197056102ENST0000036740925282239_227033873478.0DomainIQ 20
TgeneASPMchr1:209811253chr1:197056102ENST0000036740925282262_229333873478.0DomainIQ 21
TgeneASPMchr1:209811253chr1:197056102ENST0000036740925282311_234233873478.0DomainIQ 22
TgeneASPMchr1:209811253chr1:197056102ENST0000036740925282334_236533873478.0DomainIQ 23
TgeneASPMchr1:209811253chr1:197056102ENST0000036740925282384_241533873478.0DomainIQ 24
TgeneASPMchr1:209811253chr1:197056102ENST0000036740925282407_243833873478.0DomainIQ 25
TgeneASPMchr1:209811253chr1:197056102ENST0000036740925282457_248833873478.0DomainIQ 26
TgeneASPMchr1:209811253chr1:197056102ENST0000036740925282530_256133873478.0DomainIQ 27
TgeneASPMchr1:209811253chr1:197056102ENST0000036740925282624_265333873478.0DomainIQ 28
TgeneASPMchr1:209811253chr1:197056102ENST0000036740925282665_269633873478.0DomainIQ 29
TgeneASPMchr1:209811253chr1:197056102ENST0000036740925282688_271933873478.0DomainIQ 30
TgeneASPMchr1:209811253chr1:197056102ENST0000036740925282738_276733873478.0DomainIQ 31
TgeneASPMchr1:209811253chr1:197056102ENST0000036740925282859_289033873478.0DomainIQ 32
TgeneASPMchr1:209811253chr1:197056102ENST0000036740925282909_293833873478.0DomainIQ 33
TgeneASPMchr1:209811253chr1:197056102ENST0000036740925282932_296333873478.0DomainIQ 34
TgeneASPMchr1:209811253chr1:197056102ENST0000036740925282954_298533873478.0DomainIQ 35
TgeneASPMchr1:209811253chr1:197056102ENST0000036740925283029_306033873478.0DomainIQ 36
TgeneASPMchr1:209811253chr1:197056102ENST0000036740925283079_311033873478.0DomainIQ 37
TgeneASPMchr1:209811253chr1:197056102ENST0000036740925283181_321033873478.0DomainIQ 38
TgeneASPMchr1:209811253chr1:197056102ENST0000036740925283204_323533873478.0DomainIQ 39
TgeneASPMchr1:209811253chr1:197056102ENST000003674092528920_105633873478.0DomainCalponin-homology (CH) 1


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Fusion Gene Sequence for LAMB3-ASPM


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>43942_43942_1_LAMB3-ASPM_LAMB3_chr1_209811253_ENST00000391911_ASPM_chr1_197056102_ENST00000294732_length(transcript)=1231nt_BP=762nt
CTTTTCTCCTGCAAAGGGTCCAGCCTTTTCCTGCTCCCCACGTTGTCCTTACGGCTGTGTGGGGTAGGGCAGGGTCCACACTCCTTCCCA
TCCATTTTAGAGGAGGAAGCTGGAGTCTGGGAAGGGATGGGATTTTCCCAGGGCACCCTGTGAGTCACATGCCACTTGAGACAAGGGTCT
AGAGCTCCAGCATTTTCCAAGCTACAAATGTATCTGCTGCTCCAAGTGTCCTAGATCAGGACCCTAGGTAAAGACTTCTGAAAAATACTT
GAGTCTAGAAACAGAAAAGAAAAAGGGCTAGTGTGCTCTAGGGGTTTGCACTGTTGTACCCAGTTTGCTTTGCTGTGTCCTAGGAAAGGT
CCTTTCTGGGGATCACCCCATTGGCTGAAGATGAGACCATTCTTCCTCTTGTGTTTTGCCCTGCCTGGCCTCCTGCATGCCCAACAAGCC
TGCTCCCGTGGGGCCTGCTATCCACCTGTTGGGGACCTGCTTGTTGGGAGGACCCGGTTTCTCCGAGCTTCATCTACCTGTGGACTGACC
AAGCCTGAGACCTACTGCACCCAGTATGGCGAGTGGCAGATGAAATGCTGCAAGTGTGACTCCAGGCAGCCTCACAACTACTACAGTCAC
CGAGTAGAGAATGTGGCTTCATCCTCCGGCCCCATGCGCTGGTGGCAGTCACAGAATGATGTGAACCCTGTCTCTCTGCAGCTGGACCTG
GACAGGAGATTCCAGCTTCAAGAAGTCATGATGGAGTTCCAGGATGTACGAAGTAGGTCCAAAGTTGTTGACCGTATTTACAGTCTCTAC
AAACTTACAGCTCATAAACATAAAATGAATACTGAAAGAATACTTTACAAGCAAAAGAAGAATTCTTCTATAAGCATTCCTTTTATCCCA
GAAACACCTGTAAGGACCAGAATAGTTTCAAGACTTAAGCCAGATTGGGTTTTGAGAAGAGATAACATGGAAGAAATCACAAATCCCCTG
CAAGCTATTCAAATGGTGATGGATACGCTTGGCATTCCTTATTAGTAAATGTAAACATTTTCAGTATGTATAGTGTAAAGAAATATTAAA
GCCAATCATGAGTACGTAAAGTGATTTTTGCTCTCCGTGTACAACTTTTAAAATCTGACTTTGTTTTAAAAAAACATAAACTGTTCATTA

>43942_43942_1_LAMB3-ASPM_LAMB3_chr1_209811253_ENST00000391911_ASPM_chr1_197056102_ENST00000294732_length(amino acids)=239AA_BP=149
MHCCTQFALLCPRKGPFWGSPHWLKMRPFFLLCFALPGLLHAQQACSRGACYPPVGDLLVGRTRFLRASSTCGLTKPETYCTQYGEWQMK
CCKCDSRQPHNYYSHRVENVASSSGPMRWWQSQNDVNPVSLQLDLDRRFQLQEVMMEFQDVRSRSKVVDRIYSLYKLTAHKHKMNTERIL

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>43942_43942_2_LAMB3-ASPM_LAMB3_chr1_209811253_ENST00000391911_ASPM_chr1_197056102_ENST00000367408_length(transcript)=1227nt_BP=762nt
CTTTTCTCCTGCAAAGGGTCCAGCCTTTTCCTGCTCCCCACGTTGTCCTTACGGCTGTGTGGGGTAGGGCAGGGTCCACACTCCTTCCCA
TCCATTTTAGAGGAGGAAGCTGGAGTCTGGGAAGGGATGGGATTTTCCCAGGGCACCCTGTGAGTCACATGCCACTTGAGACAAGGGTCT
AGAGCTCCAGCATTTTCCAAGCTACAAATGTATCTGCTGCTCCAAGTGTCCTAGATCAGGACCCTAGGTAAAGACTTCTGAAAAATACTT
GAGTCTAGAAACAGAAAAGAAAAAGGGCTAGTGTGCTCTAGGGGTTTGCACTGTTGTACCCAGTTTGCTTTGCTGTGTCCTAGGAAAGGT
CCTTTCTGGGGATCACCCCATTGGCTGAAGATGAGACCATTCTTCCTCTTGTGTTTTGCCCTGCCTGGCCTCCTGCATGCCCAACAAGCC
TGCTCCCGTGGGGCCTGCTATCCACCTGTTGGGGACCTGCTTGTTGGGAGGACCCGGTTTCTCCGAGCTTCATCTACCTGTGGACTGACC
AAGCCTGAGACCTACTGCACCCAGTATGGCGAGTGGCAGATGAAATGCTGCAAGTGTGACTCCAGGCAGCCTCACAACTACTACAGTCAC
CGAGTAGAGAATGTGGCTTCATCCTCCGGCCCCATGCGCTGGTGGCAGTCACAGAATGATGTGAACCCTGTCTCTCTGCAGCTGGACCTG
GACAGGAGATTCCAGCTTCAAGAAGTCATGATGGAGTTCCAGGATGTACGAAGTAGGTCCAAAGTTGTTGACCGTATTTACAGTCTCTAC
AAACTTACAGCTCATAAACATAAAATGAATACTGAAAGAATACTTTACAAGCAAAAGAAGAATTCTTCTATAAGCATTCCTTTTATCCCA
GAAACACCTGTAAGGACCAGAATAGTTTCAAGACTTAAGCCAGATTGGGTTTTGAGAAGAGATAACATGGAAGAAATCACAAATCCCCTG
CAAGCTATTCAAATGGTGATGGATACGCTTGGCATTCCTTATTAGTAAATGTAAACATTTTCAGTATGTATAGTGTAAAGAAATATTAAA
GCCAATCATGAGTACGTAAAGTGATTTTTGCTCTCCGTGTACAACTTTTAAAATCTGACTTTGTTTTAAAAAAACATAAACTGTTCATTA

>43942_43942_2_LAMB3-ASPM_LAMB3_chr1_209811253_ENST00000391911_ASPM_chr1_197056102_ENST00000367408_length(amino acids)=239AA_BP=149
MHCCTQFALLCPRKGPFWGSPHWLKMRPFFLLCFALPGLLHAQQACSRGACYPPVGDLLVGRTRFLRASSTCGLTKPETYCTQYGEWQMK
CCKCDSRQPHNYYSHRVENVASSSGPMRWWQSQNDVNPVSLQLDLDRRFQLQEVMMEFQDVRSRSKVVDRIYSLYKLTAHKHKMNTERIL

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>43942_43942_3_LAMB3-ASPM_LAMB3_chr1_209811253_ENST00000391911_ASPM_chr1_197056102_ENST00000367409_length(transcript)=1231nt_BP=762nt
CTTTTCTCCTGCAAAGGGTCCAGCCTTTTCCTGCTCCCCACGTTGTCCTTACGGCTGTGTGGGGTAGGGCAGGGTCCACACTCCTTCCCA
TCCATTTTAGAGGAGGAAGCTGGAGTCTGGGAAGGGATGGGATTTTCCCAGGGCACCCTGTGAGTCACATGCCACTTGAGACAAGGGTCT
AGAGCTCCAGCATTTTCCAAGCTACAAATGTATCTGCTGCTCCAAGTGTCCTAGATCAGGACCCTAGGTAAAGACTTCTGAAAAATACTT
GAGTCTAGAAACAGAAAAGAAAAAGGGCTAGTGTGCTCTAGGGGTTTGCACTGTTGTACCCAGTTTGCTTTGCTGTGTCCTAGGAAAGGT
CCTTTCTGGGGATCACCCCATTGGCTGAAGATGAGACCATTCTTCCTCTTGTGTTTTGCCCTGCCTGGCCTCCTGCATGCCCAACAAGCC
TGCTCCCGTGGGGCCTGCTATCCACCTGTTGGGGACCTGCTTGTTGGGAGGACCCGGTTTCTCCGAGCTTCATCTACCTGTGGACTGACC
AAGCCTGAGACCTACTGCACCCAGTATGGCGAGTGGCAGATGAAATGCTGCAAGTGTGACTCCAGGCAGCCTCACAACTACTACAGTCAC
CGAGTAGAGAATGTGGCTTCATCCTCCGGCCCCATGCGCTGGTGGCAGTCACAGAATGATGTGAACCCTGTCTCTCTGCAGCTGGACCTG
GACAGGAGATTCCAGCTTCAAGAAGTCATGATGGAGTTCCAGGATGTACGAAGTAGGTCCAAAGTTGTTGACCGTATTTACAGTCTCTAC
AAACTTACAGCTCATAAACATAAAATGAATACTGAAAGAATACTTTACAAGCAAAAGAAGAATTCTTCTATAAGCATTCCTTTTATCCCA
GAAACACCTGTAAGGACCAGAATAGTTTCAAGACTTAAGCCAGATTGGGTTTTGAGAAGAGATAACATGGAAGAAATCACAAATCCCCTG
CAAGCTATTCAAATGGTGATGGATACGCTTGGCATTCCTTATTAGTAAATGTAAACATTTTCAGTATGTATAGTGTAAAGAAATATTAAA
GCCAATCATGAGTACGTAAAGTGATTTTTGCTCTCCGTGTACAACTTTTAAAATCTGACTTTGTTTTAAAAAAACATAAACTGTTCATTA

>43942_43942_3_LAMB3-ASPM_LAMB3_chr1_209811253_ENST00000391911_ASPM_chr1_197056102_ENST00000367409_length(amino acids)=239AA_BP=149
MHCCTQFALLCPRKGPFWGSPHWLKMRPFFLLCFALPGLLHAQQACSRGACYPPVGDLLVGRTRFLRASSTCGLTKPETYCTQYGEWQMK
CCKCDSRQPHNYYSHRVENVASSSGPMRWWQSQNDVNPVSLQLDLDRRFQLQEVMMEFQDVRSRSKVVDRIYSLYKLTAHKHKMNTERIL

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Fusion Gene PPI Analysis for LAMB3-ASPM


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for LAMB3-ASPM


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for LAMB3-ASPM


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource