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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:LAMC2-NMNAT2 (FusionGDB2 ID:43970)

Fusion Gene Summary for LAMC2-NMNAT2

check button Fusion gene summary
Fusion gene informationFusion gene name: LAMC2-NMNAT2
Fusion gene ID: 43970
HgeneTgene
Gene symbol

LAMC2

NMNAT2

Gene ID

3918

23057

Gene namelaminin subunit gamma 2nicotinamide nucleotide adenylyltransferase 2
SynonymsB2T|BM600|CSF|EBR2|EBR2A|LAMB2T|LAMNB2C1orf15|PNAT2
Cytomap

1q25.3

1q25.3

Type of geneprotein-codingprotein-coding
Descriptionlaminin subunit gamma-2BM600-100kDaCSF 140 kDa subunitcell-scattering factor 140 kDa subunitepiligrin subunit gammakalinin subunit gammaladsin 140 kDa subunitlaminin B2t chainlaminin, gamma 2large adhesive scatter factor 140 kDa subunitnicein sunicotinamide/nicotinic acid mononucleotide adenylyltransferase 2NMN adenylyltransferase 2NMN/NaMN adenylyltransferase 2NaMN adenylyltransferase 2nicotinamide mononucleotide adenylyltransferase 2nicotinate-nucleotide adenylyltransferase 2pyridine nuc
Modification date2020031520200313
UniProtAcc

Q13753

Q9BZQ4

Ensembl transtripts involved in fusion geneENST00000264144, ENST00000493293, 
ENST00000461729, 		ENST00000473046, 
ENST00000287713, ENST00000294868, 
Fusion gene scores* DoF score9 X 9 X 6=4868 X 8 X 5=320
# samples 911
** MAII scorelog2(9/486*10)=-2.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/320*10)=-1.5405683813627
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: LAMC2 [Title/Abstract] AND NMNAT2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointLAMC2(183155566)-NMNAT2(183262928), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across LAMC2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across NMNAT2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4UCECTCGA-EY-A3QX-01ALAMC2chr1

183155566

-NMNAT2chr1

183262928

-
ChimerDB4UCECTCGA-EY-A3QX-01ALAMC2chr1

183155566

+NMNAT2chr1

183262928

-


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Fusion Gene ORF analysis for LAMC2-NMNAT2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000264144ENST00000473046LAMC2chr1

183155566

+NMNAT2chr1

183262928

-
5CDS-intronENST00000493293ENST00000473046LAMC2chr1

183155566

+NMNAT2chr1

183262928

-
In-frameENST00000264144ENST00000287713LAMC2chr1

183155566

+NMNAT2chr1

183262928

-
In-frameENST00000264144ENST00000294868LAMC2chr1

183155566

+NMNAT2chr1

183262928

-
In-frameENST00000493293ENST00000287713LAMC2chr1

183155566

+NMNAT2chr1

183262928

-
In-frameENST00000493293ENST00000294868LAMC2chr1

183155566

+NMNAT2chr1

183262928

-
intron-3CDSENST00000461729ENST00000287713LAMC2chr1

183155566

+NMNAT2chr1

183262928

-
intron-3CDSENST00000461729ENST00000294868LAMC2chr1

183155566

+NMNAT2chr1

183262928

-
intron-intronENST00000461729ENST00000473046LAMC2chr1

183155566

+NMNAT2chr1

183262928

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000493293LAMC2chr1183155566+ENST00000294868NMNAT2chr1183262928-54371941151032305
ENST00000493293LAMC2chr1183155566+ENST00000287713NMNAT2chr1183262928-54371941151032305
ENST00000264144LAMC2chr1183155566+ENST00000294868NMNAT2chr1183262928-538714465982305
ENST00000264144LAMC2chr1183155566+ENST00000287713NMNAT2chr1183262928-538714465982305

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000493293ENST00000294868LAMC2chr1183155566+NMNAT2chr1183262928-0.0007134290.9992866
ENST00000493293ENST00000287713LAMC2chr1183155566+NMNAT2chr1183262928-0.0007134290.9992866
ENST00000264144ENST00000294868LAMC2chr1183155566+NMNAT2chr1183262928-0.0006780990.99932194
ENST00000264144ENST00000287713LAMC2chr1183155566+NMNAT2chr1183262928-0.0006780990.99932194

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Fusion Genomic Features for LAMC2-NMNAT2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for LAMC2-NMNAT2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:183155566/chr1:183262928)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LAMC2

Q13753

NMNAT2

Q9BZQ4

FUNCTION: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Ladsin exerts cell-scattering activity toward a wide variety of cells, including epithelial, endothelial, and fibroblastic cells. {ECO:0000269|PubMed:8265624}.FUNCTION: Nicotinamide/nicotinate-nucleotide adenylyltransferase that acts as an axon maintenance factor (By similarity). Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP (PubMed:16118205, PubMed:17402747). Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate but with a lower efficiency (PubMed:16118205, PubMed:17402747). Cannot use triazofurin monophosphate (TrMP) as substrate (PubMed:16118205, PubMed:17402747). Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+) (PubMed:16118205, PubMed:17402747). For the pyrophosphorolytic activity prefers NAD(+), NADH and NaAD as substrates and degrades nicotinic acid adenine dinucleotide phosphate (NHD) less effectively (PubMed:16118205, PubMed:17402747). Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NaADP(+) (PubMed:16118205, PubMed:17402747). Axon survival factor required for the maintenance of healthy axons: acts by delaying Wallerian axon degeneration, an evolutionarily conserved process that drives the loss of damaged axons (By similarity). {ECO:0000250|UniProtKB:Q8BNJ3, ECO:0000269|PubMed:16118205, ECO:0000269|PubMed:17402747}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneNMNAT2chr1:183155566chr1:183262928ENST00000287713011200_20228308.0Nucleotide bindingATP
TgeneNMNAT2chr1:183155566chr1:183262928ENST00000287713011271_27428308.0Nucleotide bindingATP
TgeneNMNAT2chr1:183155566chr1:183262928ENST00000294868011200_20223303.0Nucleotide bindingATP
TgeneNMNAT2chr1:183155566chr1:183262928ENST00000294868011271_27423303.0Nucleotide bindingATP
TgeneNMNAT2chr1:183155566chr1:183262928ENST00000287713011212_21328308.0RegionSubstrate binding
TgeneNMNAT2chr1:183155566chr1:183262928ENST0000028771301155_5728308.0RegionSubstrate binding
TgeneNMNAT2chr1:183155566chr1:183262928ENST0000028771301192_9528308.0RegionSubstrate binding
TgeneNMNAT2chr1:183155566chr1:183262928ENST00000294868011212_21323303.0RegionSubstrate binding
TgeneNMNAT2chr1:183155566chr1:183262928ENST0000029486801155_5723303.0RegionSubstrate binding
TgeneNMNAT2chr1:183155566chr1:183262928ENST0000029486801192_9523303.0RegionSubstrate binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLAMC2chr1:183155566chr1:183262928ENST00000264144+1231117_1193261194.0Coiled coilOntology_term=ECO:0000255
HgeneLAMC2chr1:183155566chr1:183262928ENST00000264144+123611_718261194.0Coiled coilOntology_term=ECO:0000255
HgeneLAMC2chr1:183155566chr1:183262928ENST00000264144+123811_1076261194.0Coiled coilOntology_term=ECO:0000255
HgeneLAMC2chr1:183155566chr1:183262928ENST00000493293+1221117_1193261112.0Coiled coilOntology_term=ECO:0000255
HgeneLAMC2chr1:183155566chr1:183262928ENST00000493293+122611_718261112.0Coiled coilOntology_term=ECO:0000255
HgeneLAMC2chr1:183155566chr1:183262928ENST00000493293+122811_1076261112.0Coiled coilOntology_term=ECO:0000255
HgeneLAMC2chr1:183155566chr1:183262928ENST00000264144+123139_186261194.0DomainLaminin EGF-like 3
HgeneLAMC2chr1:183155566chr1:183262928ENST00000264144+123187_196261194.0DomainLaminin EGF-like 4%3B first part
HgeneLAMC2chr1:183155566chr1:183262928ENST00000264144+123213_381261194.0DomainLaminin IV type A
HgeneLAMC2chr1:183155566chr1:183262928ENST00000264144+12328_83261194.0DomainLaminin EGF-like 1
HgeneLAMC2chr1:183155566chr1:183262928ENST00000264144+123382_415261194.0DomainLaminin EGF-like 4%3B second part
HgeneLAMC2chr1:183155566chr1:183262928ENST00000264144+123416_461261194.0DomainLaminin EGF-like 5
HgeneLAMC2chr1:183155566chr1:183262928ENST00000264144+123462_516261194.0DomainLaminin EGF-like 6
HgeneLAMC2chr1:183155566chr1:183262928ENST00000264144+123517_572261194.0DomainLaminin EGF-like 7
HgeneLAMC2chr1:183155566chr1:183262928ENST00000264144+123573_602261194.0DomainLaminin EGF-like 8%3B truncated
HgeneLAMC2chr1:183155566chr1:183262928ENST00000264144+12384_130261194.0DomainLaminin EGF-like 2
HgeneLAMC2chr1:183155566chr1:183262928ENST00000493293+122139_186261112.0DomainLaminin EGF-like 3
HgeneLAMC2chr1:183155566chr1:183262928ENST00000493293+122187_196261112.0DomainLaminin EGF-like 4%3B first part
HgeneLAMC2chr1:183155566chr1:183262928ENST00000493293+122213_381261112.0DomainLaminin IV type A
HgeneLAMC2chr1:183155566chr1:183262928ENST00000493293+12228_83261112.0DomainLaminin EGF-like 1
HgeneLAMC2chr1:183155566chr1:183262928ENST00000493293+122382_415261112.0DomainLaminin EGF-like 4%3B second part
HgeneLAMC2chr1:183155566chr1:183262928ENST00000493293+122416_461261112.0DomainLaminin EGF-like 5
HgeneLAMC2chr1:183155566chr1:183262928ENST00000493293+122462_516261112.0DomainLaminin EGF-like 6
HgeneLAMC2chr1:183155566chr1:183262928ENST00000493293+122517_572261112.0DomainLaminin EGF-like 7
HgeneLAMC2chr1:183155566chr1:183262928ENST00000493293+122573_602261112.0DomainLaminin EGF-like 8%3B truncated
HgeneLAMC2chr1:183155566chr1:183262928ENST00000493293+12284_130261112.0DomainLaminin EGF-like 2
HgeneLAMC2chr1:183155566chr1:183262928ENST00000264144+123603_1193261194.0RegionNote=Domain II and I
HgeneLAMC2chr1:183155566chr1:183262928ENST00000493293+122603_1193261112.0RegionNote=Domain II and I
TgeneNMNAT2chr1:183155566chr1:183262928ENST0000028771301115_1728308.0Nucleotide bindingATP
TgeneNMNAT2chr1:183155566chr1:183262928ENST0000029486801115_1723303.0Nucleotide bindingATP


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Fusion Gene Sequence for LAMC2-NMNAT2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>43970_43970_1_LAMC2-NMNAT2_LAMC2_chr1_183155566_ENST00000264144_NMNAT2_chr1_183262928_ENST00000287713_length(transcript)=5387nt_BP=144nt
ACCAACCGAGGCGCCGGGCAGCGACCCCTGCAGCGGAGACAGAGACTGAGCGGCCCGGCCCCGCCATGCCTGCGCTCTGGCTGGGCTGCT
GCCTCTGCTTCTCGCTCCTCCTGCCCGCAGCCCGGGCCACCTCCAGGAGGGAAGAAAGAGCCAGGGATTATCTGCACAAAACTGGAAGGT
TTATTGTGATTGGCGGGATTGTCTCCCCTGTCCACGACTCCTATGGAAAACAGGGCCTCGTGTCAAGCCGGCACCGTCTCATCATGTGTC
AGCTGGCCGTCCAGAATTCTGATTGGATCAGGGTGGACCCTTGGGAGTGCTACCAGGACACCTGGCAGACGACCTGCAGCGTGTTGGAAC
ACCACCGGGACCTCATGAAGAGGGTGACTGGCTGCATCCTCTCCAATGTCAACACACCTTCCATGACACCTGTGATCGGACAGCCACAAA
ACGAGACCCCCCAGCCCATTTACCAGAACAGCAACGTGGCCACCAAGCCCACTGCAGCCAAGATCTTGGGGAAGGTGGGAGAAAGCCTCA
GCCGGATCTGCTGTGTCCGCCCGCCGGTGGAGCGTTTCACCTTTGTAGATGAGAATGCCAATCTGGGCACGGTGATGCGGTATGAAGAGA
TTGAGCTACGGATCCTGCTGCTGTGTGGTAGTGACCTGCTGGAGTCCTTCTGCATCCCAGGGCTCTGGAACGAGGCAGATATGGAGGTGA
TTGTTGGTGACTTTGGGATTGTGGTGGTGCCCCGGGATGCAGCCGACACAGACCGAATCATGAATCACTCCTCAATACTCCGCAAATACA
AAAACAACATCATGGTGGTGAAGGATGACATCAACCATCCCATGTCTGTTGTCAGCTCAACCAAGAGCAGGCTGGCCCTGCAGCATGGGG
ACGGCCATGTTGTGGATTACCTGTCCCAGCCGGTCATCGACTACATCCTCAAAAGCCAGCTGTACATCAATGCCTCCGGCTAGCAGCCCC
TCGTCCTCCGGCAACACAATGGCCCCTCCATCTTTGTCAGCCCCCTGTTTCTCTCCTGCCTCTCTGTTTCTCCATCTCCTCGTCTTGACT
GTTTTCCCTACTTGCTGACTTAACCCCCCATAGTGTGGGGGACCTGCAGAGAACCATGGCATTCCCTATTCCACAGTCATCTTTGGACAG
ACTTTCCTCTAGTCTCCGGGTTGGGGGTGGGTGAGGGAATGGGGTGGGAGTCGGGGGAAGTGCAGTCCTTGGAGATGTACTGGTGTCCGT
CTCCCAGCATGCTCTAGAGAGGCGGCTCTGGTGCCCATCCTCCCAGCACGCTCTGGGGAGGCGGCTCTGGTGCCCATCCTCCCAGCATGC
TCTAGAGAGGCGGCTCTGGTGCCCCTCCTCCCAGCATGCTCTGGGGAGGCGGCTCTGGCTCTTGCCTTCCCAGCATGCCCTTTACTACAA
AGGGCTATTTTTCTTTTCTTTCTTTTGTTTATTTATTTTTCTTTGTTCACTCCCTGTAGAACTTGGATGAAATCAGTGTCCATGGTTCTT
TATGTTTGTAGTCTTGATGTGCTCCTGTGGTATTACTTCCCCTCTGATAGGACATTGTAGCCAGCCTCAGCACTCAGTGAGTTCATCAGG
GCCACACCCAGTAGAGAAGGCCAAGCAACCTCCACTTCTTCAGCACCACACACACGCACACACACACACACGCACACATGCGTGTGCACC
CGCGCACGCACATACACACACACATATAGCAGTAGCAGCAGCAGCAGCAGCAGCAGCAACCTTTGATCAGGAGTGAGATTTTCGGGTTCT
GAAACCTGGGACACGAGTCTGTGAATAGTCGGTTTTCTCAGAATAATTTGAATCTGTTTTCTTAGTTTCAAATGACCATTTCCCTGATGC
TCTGAGCTTATGATCACACAGAGCCAGTCCATCCTCATTTCCTGGTGGCATCTGTTCATTTACCTTTGTGGACTGTAGCTGATGGCACAG
TGCGGGTTCCCTACCAGCCAGGGGTTTCCAAGGGACCTTTGGAGGCCATGCTTAGACACATTCCTGTACCTGAGAACAACCACATAGGCA
GGACCAGATCCACATCGTGCAGTCGTGTCATAAAAAAACAAAACAAAACAAAAAAACACTAGGAGTCCACTCAACCCTGGAGGTCTTTGC
TAATTGGAATTATGTATTGTCTGTTGGGCTGGGAAATGTCTCTTTCATATTGTAAGTCCAGGATGAACTAGGAGAAAGCAATTTGTTGCC
CTGATGATAACTGATGATTTTCACCCTCTCTAGCTGAGGTAACTCAGACAGTGCATGAGGTCAGTTTCTTCTTGAGAAGCAGTGCCTTGG
TCTTGTTTCTGTGGTTGGTTCTAGCCCCTGCAGAGCCTGGGAGCTGCAGGAACTGTCTGAGAAAATCTCCCTAATAGGGGAGTGGGTTCC
CAGAAGGGAGATCTGGGAGGGGTCAGGAGCCACTAAGTTGCTTCACTCCTTTTTTCTCTAATTTTCTACCTTCCTCTCTGTTCCTGCAGA
CAGTTTTGCCAGCTTTGCTTCTGGTTACTAGGGTCTCATGCGTGTCCTGCTTGGAGAGCCATAAGGAAATTGCTGTCTTGTGCTTTGTGT
CTCTCATCCAGTCTCTGGCTCTTGGGATTCTGGTCTTTGAGAAATAGTCCCTGAGTATTAGGATACTTTTATCAAAATCTAGTACCAGCT
ACGGCCAGAAAGGGCCAGGTGGGACCTGAAAGCAAAGACAATGTTCTTTACCACACGTTTCACATCTGCAACATCCTTCAATTGCGGGAA
AAGGAACTTGATTTAACAGAAGAACATGGTAGAGCAGCATCCAGAAAGTCTGTTATTCCTCTTGGATTTTTTGAAATAATCTTCAGAGGA
AGGAAGGAAAATCCTATTTTGGGGTATCAGTGTTTGACTAGGGATCATGAAATAATAAACTGAAAAAAACTTTAGAGTTCAGTTGATCCA
ACACTTTCCTTTAAAAGTTGAGGGAGCAGAGGCCCATGGGATTAAATGGCTGGTCCAGGTCAGCCAGCAGGTGTAGGGCCTGACAAGAAC
ATATTGTTTCCCTGACCCCTAGGCCGTCACACCACACCCTCCATTTCCTCATGTTGCTGACCAGGTGCCCATATGATTTCTACACTTCCC
AAGCCTTACCCTGGCATCTTTCTTTTAAATTATATCTGTCCCAGGTGCTCTCCACACATAGGATGGTAATGCCAGTCCCAGGGGAGGGTG
TGATAGTAAGGAAGGCCACTGTTAGGTTTCCTTTAGAAATAAAGAGATCTCAGCAGCTTGGAAGAAATCCCAGAAGCGGACTCCATCAAT
CCAAGAAAGAGTTGCTTTGTGGAAGGTGAAGGAAGACCCACAGAGTGCTCAGGATGATGCTATTGCTGGAGAGCGAAAGATGGAACAGCC
TTGTCCAGGCAGAACAGTCATAAGCCAGGAAATGAAACAAAGGAAAACAGGTGCCTGAATTTCCTGGGGAAACATGGCTTGTTTAAGGAC
TTGGAGTTATGGATGGAATTTATGGGACCCACGTGAGCAGACCTGAGGAAGGCTCGATTTCTTTTGTTTCTTGGTCCACTCTGTCACTCT
GCTCTGGTCAAGCCCCATTTGGTCTACAGCCCATGAGAAGGAATGAGGCTGGTTCTGCACTCTCAGCATGCAGTCCGAAAGCATGTGGGA
GTGGGGAGGGAAAGTGAGATGAATTAAGACAAAGAACAGGTGCCATAGAAGTAGATTTCTAGGAATGAAGTGGGGCAGATCTTATCTTTG
TGGATTACAGGCACTGTACTAAAAACAGGTTTCCTATTTAATATAAAAAGAAAGTGAATCTTCTTTTGGATAGAATCATCCATTCCCATC
GCCGCACCCCCTACCCCCCAAACACACACACACACACACACACACACACACACACACACACACACACACACGCCCTACTCTTCATTTGCT
AGGGGAAGGTCACAGCACAACTAAATCCAGGACAGGACATTGTGACCATGACCCAGCCACAGTCAATACCAGAAAGATGATTCAGAGTCT
GAAGTGGTGCCCCAGGTGCCAACAGGATAACCTCTACCCCCCGACTTTGTCTCTGGGGTCCTGTTCCTTCCTGCAAAGCCCAATCCAAGA
CTGGCATGGCTCAGAGGTTGTGAGAAAGGCATGGACTGGAACAATCATGTCCAGAGGGGTCTGGAGCTTTGTTTCCTGTTCACCAGCAAA
AAATGTCTCTCCCATTTTTCTGAAAGTGGCTGATGTAAGAACAGGCAGAAGGAAAACCCTTTTTGTCAATAACTCTGTCCTTAAGGAATG
GTCCTCTGGGAGGGCTGTGCTGCTAGTGGGTACCTCAGTCACACACCCCCAACCCCAGGCAGCCTCTAGAGCCTTCTTGCTTTCATTTTC
CTTGAATGTACATAGGAACAAGGGGGAAAGTCTCTTACTGAAGTGCCTGAAACCCAAAGCTAGAGCTTCTAGAGACGCCGTTCTTCCTGT
CTCAGCTTGGCCAGCCTTTCAACAATGTTCTCTAGTTTCAAGCTCCAGCTTCTCAGAAAGAATTAAAGAACTTGCTGTTCAAATTAAGTA
GAAAGTGAGACTCAATAATAACTGAACTACAGCAAAAGGCAGAGAATTACAGGGAGAAAAAACTTGTACTTACCAGCCCAATTCTACTCT
CCTCAAACTGACACACACACACACACACACACACACACACACACACACACACTCTTTTAGGGGACTAAGAGAGAGAAGCATGTTATTACA
TTTTACTCATCCAAACAGTAATGCAAAAATAAAACGGTAGAATATGAAAAGCTCAGGATCTCTCCCAAGGCTACCTACTGCAGGAGGGCC
AACAGGTGAGATGGGAAGAATGGAAACAGGGACCGATTTTGTAGCTCATACAATTAGGACACCTTAGGAATAGCATTGTAGTAATGGTGA
TGAATATGCTCTGCCAAATTCATCCAGTCTGCACCATCTTATAGCTGCCCAGCACACTCGACTGTTCATGTGGTCTCTTTGTAGTGTGAG
TTTGGAGTGTCCTATTAGCCTGTTCTGGTTAGGAATGAGTTAACGGCTCTTTCCCTCAACCTTAGTCTAGTCCCAGGGCTGAGGATTCAG
CTGGATCCACATGGTCTTGAGGGTTGGCATGAGGAGGGGGAAGCTTTTTTGAATCGCTTTTTGATCACATAATCTGCCATTTTAAGAGTA
AGATTTGCTTTATGGAAATCAATTCATTAATAAAAAATGATATTCAAGTTGCAATACCATTTCACAGTGAAATATTTTGAGTACAATTTT

>43970_43970_1_LAMC2-NMNAT2_LAMC2_chr1_183155566_ENST00000264144_NMNAT2_chr1_183262928_ENST00000287713_length(amino acids)=305AA_BP=26
MPALWLGCCLCFSLLLPAARATSRREERARDYLHKTGRFIVIGGIVSPVHDSYGKQGLVSSRHRLIMCQLAVQNSDWIRVDPWECYQDTW
QTTCSVLEHHRDLMKRVTGCILSNVNTPSMTPVIGQPQNETPQPIYQNSNVATKPTAAKILGKVGESLSRICCVRPPVERFTFVDENANL
GTVMRYEEIELRILLLCGSDLLESFCIPGLWNEADMEVIVGDFGIVVVPRDAADTDRIMNHSSILRKYKNNIMVVKDDINHPMSVVSSTK

--------------------------------------------------------------
>43970_43970_2_LAMC2-NMNAT2_LAMC2_chr1_183155566_ENST00000264144_NMNAT2_chr1_183262928_ENST00000294868_length(transcript)=5387nt_BP=144nt
ACCAACCGAGGCGCCGGGCAGCGACCCCTGCAGCGGAGACAGAGACTGAGCGGCCCGGCCCCGCCATGCCTGCGCTCTGGCTGGGCTGCT
GCCTCTGCTTCTCGCTCCTCCTGCCCGCAGCCCGGGCCACCTCCAGGAGGGAAGAAAGAGCCAGGGATTATCTGCACAAAACTGGAAGGT
TTATTGTGATTGGCGGGATTGTCTCCCCTGTCCACGACTCCTATGGAAAACAGGGCCTCGTGTCAAGCCGGCACCGTCTCATCATGTGTC
AGCTGGCCGTCCAGAATTCTGATTGGATCAGGGTGGACCCTTGGGAGTGCTACCAGGACACCTGGCAGACGACCTGCAGCGTGTTGGAAC
ACCACCGGGACCTCATGAAGAGGGTGACTGGCTGCATCCTCTCCAATGTCAACACACCTTCCATGACACCTGTGATCGGACAGCCACAAA
ACGAGACCCCCCAGCCCATTTACCAGAACAGCAACGTGGCCACCAAGCCCACTGCAGCCAAGATCTTGGGGAAGGTGGGAGAAAGCCTCA
GCCGGATCTGCTGTGTCCGCCCGCCGGTGGAGCGTTTCACCTTTGTAGATGAGAATGCCAATCTGGGCACGGTGATGCGGTATGAAGAGA
TTGAGCTACGGATCCTGCTGCTGTGTGGTAGTGACCTGCTGGAGTCCTTCTGCATCCCAGGGCTCTGGAACGAGGCAGATATGGAGGTGA
TTGTTGGTGACTTTGGGATTGTGGTGGTGCCCCGGGATGCAGCCGACACAGACCGAATCATGAATCACTCCTCAATACTCCGCAAATACA
AAAACAACATCATGGTGGTGAAGGATGACATCAACCATCCCATGTCTGTTGTCAGCTCAACCAAGAGCAGGCTGGCCCTGCAGCATGGGG
ACGGCCATGTTGTGGATTACCTGTCCCAGCCGGTCATCGACTACATCCTCAAAAGCCAGCTGTACATCAATGCCTCCGGCTAGCAGCCCC
TCGTCCTCCGGCAACACAATGGCCCCTCCATCTTTGTCAGCCCCCTGTTTCTCTCCTGCCTCTCTGTTTCTCCATCTCCTCGTCTTGACT
GTTTTCCCTACTTGCTGACTTAACCCCCCATAGTGTGGGGGACCTGCAGAGAACCATGGCATTCCCTATTCCACAGTCATCTTTGGACAG
ACTTTCCTCTAGTCTCCGGGTTGGGGGTGGGTGAGGGAATGGGGTGGGAGTCGGGGGAAGTGCAGTCCTTGGAGATGTACTGGTGTCCGT
CTCCCAGCATGCTCTAGAGAGGCGGCTCTGGTGCCCATCCTCCCAGCACGCTCTGGGGAGGCGGCTCTGGTGCCCATCCTCCCAGCATGC
TCTAGAGAGGCGGCTCTGGTGCCCCTCCTCCCAGCATGCTCTGGGGAGGCGGCTCTGGCTCTTGCCTTCCCAGCATGCCCTTTACTACAA
AGGGCTATTTTTCTTTTCTTTCTTTTGTTTATTTATTTTTCTTTGTTCACTCCCTGTAGAACTTGGATGAAATCAGTGTCCATGGTTCTT
TATGTTTGTAGTCTTGATGTGCTCCTGTGGTATTACTTCCCCTCTGATAGGACATTGTAGCCAGCCTCAGCACTCAGTGAGTTCATCAGG
GCCACACCCAGTAGAGAAGGCCAAGCAACCTCCACTTCTTCAGCACCACACACACGCACACACACACACACGCACACATGCGTGTGCACC
CGCGCACGCACATACACACACACATATAGCAGTAGCAGCAGCAGCAGCAGCAGCAGCAACCTTTGATCAGGAGTGAGATTTTCGGGTTCT
GAAACCTGGGACACGAGTCTGTGAATAGTCGGTTTTCTCAGAATAATTTGAATCTGTTTTCTTAGTTTCAAATGACCATTTCCCTGATGC
TCTGAGCTTATGATCACACAGAGCCAGTCCATCCTCATTTCCTGGTGGCATCTGTTCATTTACCTTTGTGGACTGTAGCTGATGGCACAG
TGCGGGTTCCCTACCAGCCAGGGGTTTCCAAGGGACCTTTGGAGGCCATGCTTAGACACATTCCTGTACCTGAGAACAACCACATAGGCA
GGACCAGATCCACATCGTGCAGTCGTGTCATAAAAAAACAAAACAAAACAAAAAAACACTAGGAGTCCACTCAACCCTGGAGGTCTTTGC
TAATTGGAATTATGTATTGTCTGTTGGGCTGGGAAATGTCTCTTTCATATTGTAAGTCCAGGATGAACTAGGAGAAAGCAATTTGTTGCC
CTGATGATAACTGATGATTTTCACCCTCTCTAGCTGAGGTAACTCAGACAGTGCATGAGGTCAGTTTCTTCTTGAGAAGCAGTGCCTTGG
TCTTGTTTCTGTGGTTGGTTCTAGCCCCTGCAGAGCCTGGGAGCTGCAGGAACTGTCTGAGAAAATCTCCCTAATAGGGGAGTGGGTTCC
CAGAAGGGAGATCTGGGAGGGGTCAGGAGCCACTAAGTTGCTTCACTCCTTTTTTCTCTAATTTTCTACCTTCCTCTCTGTTCCTGCAGA
CAGTTTTGCCAGCTTTGCTTCTGGTTACTAGGGTCTCATGCGTGTCCTGCTTGGAGAGCCATAAGGAAATTGCTGTCTTGTGCTTTGTGT
CTCTCATCCAGTCTCTGGCTCTTGGGATTCTGGTCTTTGAGAAATAGTCCCTGAGTATTAGGATACTTTTATCAAAATCTAGTACCAGCT
ACGGCCAGAAAGGGCCAGGTGGGACCTGAAAGCAAAGACAATGTTCTTTACCACACGTTTCACATCTGCAACATCCTTCAATTGCGGGAA
AAGGAACTTGATTTAACAGAAGAACATGGTAGAGCAGCATCCAGAAAGTCTGTTATTCCTCTTGGATTTTTTGAAATAATCTTCAGAGGA
AGGAAGGAAAATCCTATTTTGGGGTATCAGTGTTTGACTAGGGATCATGAAATAATAAACTGAAAAAAACTTTAGAGTTCAGTTGATCCA
ACACTTTCCTTTAAAAGTTGAGGGAGCAGAGGCCCATGGGATTAAATGGCTGGTCCAGGTCAGCCAGCAGGTGTAGGGCCTGACAAGAAC
ATATTGTTTCCCTGACCCCTAGGCCGTCACACCACACCCTCCATTTCCTCATGTTGCTGACCAGGTGCCCATATGATTTCTACACTTCCC
AAGCCTTACCCTGGCATCTTTCTTTTAAATTATATCTGTCCCAGGTGCTCTCCACACATAGGATGGTAATGCCAGTCCCAGGGGAGGGTG
TGATAGTAAGGAAGGCCACTGTTAGGTTTCCTTTAGAAATAAAGAGATCTCAGCAGCTTGGAAGAAATCCCAGAAGCGGACTCCATCAAT
CCAAGAAAGAGTTGCTTTGTGGAAGGTGAAGGAAGACCCACAGAGTGCTCAGGATGATGCTATTGCTGGAGAGCGAAAGATGGAACAGCC
TTGTCCAGGCAGAACAGTCATAAGCCAGGAAATGAAACAAAGGAAAACAGGTGCCTGAATTTCCTGGGGAAACATGGCTTGTTTAAGGAC
TTGGAGTTATGGATGGAATTTATGGGACCCACGTGAGCAGACCTGAGGAAGGCTCGATTTCTTTTGTTTCTTGGTCCACTCTGTCACTCT
GCTCTGGTCAAGCCCCATTTGGTCTACAGCCCATGAGAAGGAATGAGGCTGGTTCTGCACTCTCAGCATGCAGTCCGAAAGCATGTGGGA
GTGGGGAGGGAAAGTGAGATGAATTAAGACAAAGAACAGGTGCCATAGAAGTAGATTTCTAGGAATGAAGTGGGGCAGATCTTATCTTTG
TGGATTACAGGCACTGTACTAAAAACAGGTTTCCTATTTAATATAAAAAGAAAGTGAATCTTCTTTTGGATAGAATCATCCATTCCCATC
GCCGCACCCCCTACCCCCCAAACACACACACACACACACACACACACACACACACACACACACACACACACGCCCTACTCTTCATTTGCT
AGGGGAAGGTCACAGCACAACTAAATCCAGGACAGGACATTGTGACCATGACCCAGCCACAGTCAATACCAGAAAGATGATTCAGAGTCT
GAAGTGGTGCCCCAGGTGCCAACAGGATAACCTCTACCCCCCGACTTTGTCTCTGGGGTCCTGTTCCTTCCTGCAAAGCCCAATCCAAGA
CTGGCATGGCTCAGAGGTTGTGAGAAAGGCATGGACTGGAACAATCATGTCCAGAGGGGTCTGGAGCTTTGTTTCCTGTTCACCAGCAAA
AAATGTCTCTCCCATTTTTCTGAAAGTGGCTGATGTAAGAACAGGCAGAAGGAAAACCCTTTTTGTCAATAACTCTGTCCTTAAGGAATG
GTCCTCTGGGAGGGCTGTGCTGCTAGTGGGTACCTCAGTCACACACCCCCAACCCCAGGCAGCCTCTAGAGCCTTCTTGCTTTCATTTTC
CTTGAATGTACATAGGAACAAGGGGGAAAGTCTCTTACTGAAGTGCCTGAAACCCAAAGCTAGAGCTTCTAGAGACGCCGTTCTTCCTGT
CTCAGCTTGGCCAGCCTTTCAACAATGTTCTCTAGTTTCAAGCTCCAGCTTCTCAGAAAGAATTAAAGAACTTGCTGTTCAAATTAAGTA
GAAAGTGAGACTCAATAATAACTGAACTACAGCAAAAGGCAGAGAATTACAGGGAGAAAAAACTTGTACTTACCAGCCCAATTCTACTCT
CCTCAAACTGACACACACACACACACACACACACACACACACACACACACACTCTTTTAGGGGACTAAGAGAGAGAAGCATGTTATTACA
TTTTACTCATCCAAACAGTAATGCAAAAATAAAACGGTAGAATATGAAAAGCTCAGGATCTCTCCCAAGGCTACCTACTGCAGGAGGGCC
AACAGGTGAGATGGGAAGAATGGAAACAGGGACCGATTTTGTAGCTCATACAATTAGGACACCTTAGGAATAGCATTGTAGTAATGGTGA
TGAATATGCTCTGCCAAATTCATCCAGTCTGCACCATCTTATAGCTGCCCAGCACACTCGACTGTTCATGTGGTCTCTTTGTAGTGTGAG
TTTGGAGTGTCCTATTAGCCTGTTCTGGTTAGGAATGAGTTAACGGCTCTTTCCCTCAACCTTAGTCTAGTCCCAGGGCTGAGGATTCAG
CTGGATCCACATGGTCTTGAGGGTTGGCATGAGGAGGGGGAAGCTTTTTTGAATCGCTTTTTGATCACATAATCTGCCATTTTAAGAGTA
AGATTTGCTTTATGGAAATCAATTCATTAATAAAAAATGATATTCAAGTTGCAATACCATTTCACAGTGAAATATTTTGAGTACAATTTT

>43970_43970_2_LAMC2-NMNAT2_LAMC2_chr1_183155566_ENST00000264144_NMNAT2_chr1_183262928_ENST00000294868_length(amino acids)=305AA_BP=26
MPALWLGCCLCFSLLLPAARATSRREERARDYLHKTGRFIVIGGIVSPVHDSYGKQGLVSSRHRLIMCQLAVQNSDWIRVDPWECYQDTW
QTTCSVLEHHRDLMKRVTGCILSNVNTPSMTPVIGQPQNETPQPIYQNSNVATKPTAAKILGKVGESLSRICCVRPPVERFTFVDENANL
GTVMRYEEIELRILLLCGSDLLESFCIPGLWNEADMEVIVGDFGIVVVPRDAADTDRIMNHSSILRKYKNNIMVVKDDINHPMSVVSSTK

--------------------------------------------------------------
>43970_43970_3_LAMC2-NMNAT2_LAMC2_chr1_183155566_ENST00000493293_NMNAT2_chr1_183262928_ENST00000287713_length(transcript)=5437nt_BP=194nt
ACCACCTGATCAAGGAAAAGGAAGGCACAGCGGAGCGCAGAGTGAGAACCACCAACCGAGGCGCCGGGCAGCGACCCCTGCAGCGGAGAC
AGAGACTGAGCGGCCCGGCCCCGCCATGCCTGCGCTCTGGCTGGGCTGCTGCCTCTGCTTCTCGCTCCTCCTGCCCGCAGCCCGGGCCAC
CTCCAGGAGGGAAGAAAGAGCCAGGGATTATCTGCACAAAACTGGAAGGTTTATTGTGATTGGCGGGATTGTCTCCCCTGTCCACGACTC
CTATGGAAAACAGGGCCTCGTGTCAAGCCGGCACCGTCTCATCATGTGTCAGCTGGCCGTCCAGAATTCTGATTGGATCAGGGTGGACCC
TTGGGAGTGCTACCAGGACACCTGGCAGACGACCTGCAGCGTGTTGGAACACCACCGGGACCTCATGAAGAGGGTGACTGGCTGCATCCT
CTCCAATGTCAACACACCTTCCATGACACCTGTGATCGGACAGCCACAAAACGAGACCCCCCAGCCCATTTACCAGAACAGCAACGTGGC
CACCAAGCCCACTGCAGCCAAGATCTTGGGGAAGGTGGGAGAAAGCCTCAGCCGGATCTGCTGTGTCCGCCCGCCGGTGGAGCGTTTCAC
CTTTGTAGATGAGAATGCCAATCTGGGCACGGTGATGCGGTATGAAGAGATTGAGCTACGGATCCTGCTGCTGTGTGGTAGTGACCTGCT
GGAGTCCTTCTGCATCCCAGGGCTCTGGAACGAGGCAGATATGGAGGTGATTGTTGGTGACTTTGGGATTGTGGTGGTGCCCCGGGATGC
AGCCGACACAGACCGAATCATGAATCACTCCTCAATACTCCGCAAATACAAAAACAACATCATGGTGGTGAAGGATGACATCAACCATCC
CATGTCTGTTGTCAGCTCAACCAAGAGCAGGCTGGCCCTGCAGCATGGGGACGGCCATGTTGTGGATTACCTGTCCCAGCCGGTCATCGA
CTACATCCTCAAAAGCCAGCTGTACATCAATGCCTCCGGCTAGCAGCCCCTCGTCCTCCGGCAACACAATGGCCCCTCCATCTTTGTCAG
CCCCCTGTTTCTCTCCTGCCTCTCTGTTTCTCCATCTCCTCGTCTTGACTGTTTTCCCTACTTGCTGACTTAACCCCCCATAGTGTGGGG
GACCTGCAGAGAACCATGGCATTCCCTATTCCACAGTCATCTTTGGACAGACTTTCCTCTAGTCTCCGGGTTGGGGGTGGGTGAGGGAAT
GGGGTGGGAGTCGGGGGAAGTGCAGTCCTTGGAGATGTACTGGTGTCCGTCTCCCAGCATGCTCTAGAGAGGCGGCTCTGGTGCCCATCC
TCCCAGCACGCTCTGGGGAGGCGGCTCTGGTGCCCATCCTCCCAGCATGCTCTAGAGAGGCGGCTCTGGTGCCCCTCCTCCCAGCATGCT
CTGGGGAGGCGGCTCTGGCTCTTGCCTTCCCAGCATGCCCTTTACTACAAAGGGCTATTTTTCTTTTCTTTCTTTTGTTTATTTATTTTT
CTTTGTTCACTCCCTGTAGAACTTGGATGAAATCAGTGTCCATGGTTCTTTATGTTTGTAGTCTTGATGTGCTCCTGTGGTATTACTTCC
CCTCTGATAGGACATTGTAGCCAGCCTCAGCACTCAGTGAGTTCATCAGGGCCACACCCAGTAGAGAAGGCCAAGCAACCTCCACTTCTT
CAGCACCACACACACGCACACACACACACACGCACACATGCGTGTGCACCCGCGCACGCACATACACACACACATATAGCAGTAGCAGCA
GCAGCAGCAGCAGCAGCAACCTTTGATCAGGAGTGAGATTTTCGGGTTCTGAAACCTGGGACACGAGTCTGTGAATAGTCGGTTTTCTCA
GAATAATTTGAATCTGTTTTCTTAGTTTCAAATGACCATTTCCCTGATGCTCTGAGCTTATGATCACACAGAGCCAGTCCATCCTCATTT
CCTGGTGGCATCTGTTCATTTACCTTTGTGGACTGTAGCTGATGGCACAGTGCGGGTTCCCTACCAGCCAGGGGTTTCCAAGGGACCTTT
GGAGGCCATGCTTAGACACATTCCTGTACCTGAGAACAACCACATAGGCAGGACCAGATCCACATCGTGCAGTCGTGTCATAAAAAAACA
AAACAAAACAAAAAAACACTAGGAGTCCACTCAACCCTGGAGGTCTTTGCTAATTGGAATTATGTATTGTCTGTTGGGCTGGGAAATGTC
TCTTTCATATTGTAAGTCCAGGATGAACTAGGAGAAAGCAATTTGTTGCCCTGATGATAACTGATGATTTTCACCCTCTCTAGCTGAGGT
AACTCAGACAGTGCATGAGGTCAGTTTCTTCTTGAGAAGCAGTGCCTTGGTCTTGTTTCTGTGGTTGGTTCTAGCCCCTGCAGAGCCTGG
GAGCTGCAGGAACTGTCTGAGAAAATCTCCCTAATAGGGGAGTGGGTTCCCAGAAGGGAGATCTGGGAGGGGTCAGGAGCCACTAAGTTG
CTTCACTCCTTTTTTCTCTAATTTTCTACCTTCCTCTCTGTTCCTGCAGACAGTTTTGCCAGCTTTGCTTCTGGTTACTAGGGTCTCATG
CGTGTCCTGCTTGGAGAGCCATAAGGAAATTGCTGTCTTGTGCTTTGTGTCTCTCATCCAGTCTCTGGCTCTTGGGATTCTGGTCTTTGA
GAAATAGTCCCTGAGTATTAGGATACTTTTATCAAAATCTAGTACCAGCTACGGCCAGAAAGGGCCAGGTGGGACCTGAAAGCAAAGACA
ATGTTCTTTACCACACGTTTCACATCTGCAACATCCTTCAATTGCGGGAAAAGGAACTTGATTTAACAGAAGAACATGGTAGAGCAGCAT
CCAGAAAGTCTGTTATTCCTCTTGGATTTTTTGAAATAATCTTCAGAGGAAGGAAGGAAAATCCTATTTTGGGGTATCAGTGTTTGACTA
GGGATCATGAAATAATAAACTGAAAAAAACTTTAGAGTTCAGTTGATCCAACACTTTCCTTTAAAAGTTGAGGGAGCAGAGGCCCATGGG
ATTAAATGGCTGGTCCAGGTCAGCCAGCAGGTGTAGGGCCTGACAAGAACATATTGTTTCCCTGACCCCTAGGCCGTCACACCACACCCT
CCATTTCCTCATGTTGCTGACCAGGTGCCCATATGATTTCTACACTTCCCAAGCCTTACCCTGGCATCTTTCTTTTAAATTATATCTGTC
CCAGGTGCTCTCCACACATAGGATGGTAATGCCAGTCCCAGGGGAGGGTGTGATAGTAAGGAAGGCCACTGTTAGGTTTCCTTTAGAAAT
AAAGAGATCTCAGCAGCTTGGAAGAAATCCCAGAAGCGGACTCCATCAATCCAAGAAAGAGTTGCTTTGTGGAAGGTGAAGGAAGACCCA
CAGAGTGCTCAGGATGATGCTATTGCTGGAGAGCGAAAGATGGAACAGCCTTGTCCAGGCAGAACAGTCATAAGCCAGGAAATGAAACAA
AGGAAAACAGGTGCCTGAATTTCCTGGGGAAACATGGCTTGTTTAAGGACTTGGAGTTATGGATGGAATTTATGGGACCCACGTGAGCAG
ACCTGAGGAAGGCTCGATTTCTTTTGTTTCTTGGTCCACTCTGTCACTCTGCTCTGGTCAAGCCCCATTTGGTCTACAGCCCATGAGAAG
GAATGAGGCTGGTTCTGCACTCTCAGCATGCAGTCCGAAAGCATGTGGGAGTGGGGAGGGAAAGTGAGATGAATTAAGACAAAGAACAGG
TGCCATAGAAGTAGATTTCTAGGAATGAAGTGGGGCAGATCTTATCTTTGTGGATTACAGGCACTGTACTAAAAACAGGTTTCCTATTTA
ATATAAAAAGAAAGTGAATCTTCTTTTGGATAGAATCATCCATTCCCATCGCCGCACCCCCTACCCCCCAAACACACACACACACACACA
CACACACACACACACACACACACACACACACGCCCTACTCTTCATTTGCTAGGGGAAGGTCACAGCACAACTAAATCCAGGACAGGACAT
TGTGACCATGACCCAGCCACAGTCAATACCAGAAAGATGATTCAGAGTCTGAAGTGGTGCCCCAGGTGCCAACAGGATAACCTCTACCCC
CCGACTTTGTCTCTGGGGTCCTGTTCCTTCCTGCAAAGCCCAATCCAAGACTGGCATGGCTCAGAGGTTGTGAGAAAGGCATGGACTGGA
ACAATCATGTCCAGAGGGGTCTGGAGCTTTGTTTCCTGTTCACCAGCAAAAAATGTCTCTCCCATTTTTCTGAAAGTGGCTGATGTAAGA
ACAGGCAGAAGGAAAACCCTTTTTGTCAATAACTCTGTCCTTAAGGAATGGTCCTCTGGGAGGGCTGTGCTGCTAGTGGGTACCTCAGTC
ACACACCCCCAACCCCAGGCAGCCTCTAGAGCCTTCTTGCTTTCATTTTCCTTGAATGTACATAGGAACAAGGGGGAAAGTCTCTTACTG
AAGTGCCTGAAACCCAAAGCTAGAGCTTCTAGAGACGCCGTTCTTCCTGTCTCAGCTTGGCCAGCCTTTCAACAATGTTCTCTAGTTTCA
AGCTCCAGCTTCTCAGAAAGAATTAAAGAACTTGCTGTTCAAATTAAGTAGAAAGTGAGACTCAATAATAACTGAACTACAGCAAAAGGC
AGAGAATTACAGGGAGAAAAAACTTGTACTTACCAGCCCAATTCTACTCTCCTCAAACTGACACACACACACACACACACACACACACAC
ACACACACACACTCTTTTAGGGGACTAAGAGAGAGAAGCATGTTATTACATTTTACTCATCCAAACAGTAATGCAAAAATAAAACGGTAG
AATATGAAAAGCTCAGGATCTCTCCCAAGGCTACCTACTGCAGGAGGGCCAACAGGTGAGATGGGAAGAATGGAAACAGGGACCGATTTT
GTAGCTCATACAATTAGGACACCTTAGGAATAGCATTGTAGTAATGGTGATGAATATGCTCTGCCAAATTCATCCAGTCTGCACCATCTT
ATAGCTGCCCAGCACACTCGACTGTTCATGTGGTCTCTTTGTAGTGTGAGTTTGGAGTGTCCTATTAGCCTGTTCTGGTTAGGAATGAGT
TAACGGCTCTTTCCCTCAACCTTAGTCTAGTCCCAGGGCTGAGGATTCAGCTGGATCCACATGGTCTTGAGGGTTGGCATGAGGAGGGGG
AAGCTTTTTTGAATCGCTTTTTGATCACATAATCTGCCATTTTAAGAGTAAGATTTGCTTTATGGAAATCAATTCATTAATAAAAAATGA
TATTCAAGTTGCAATACCATTTCACAGTGAAATATTTTGAGTACAATTTTGTTGCTAGAATAGTCATGGGCAAGAGTTTTATGCAAAATG

>43970_43970_3_LAMC2-NMNAT2_LAMC2_chr1_183155566_ENST00000493293_NMNAT2_chr1_183262928_ENST00000287713_length(amino acids)=305AA_BP=26
MPALWLGCCLCFSLLLPAARATSRREERARDYLHKTGRFIVIGGIVSPVHDSYGKQGLVSSRHRLIMCQLAVQNSDWIRVDPWECYQDTW
QTTCSVLEHHRDLMKRVTGCILSNVNTPSMTPVIGQPQNETPQPIYQNSNVATKPTAAKILGKVGESLSRICCVRPPVERFTFVDENANL
GTVMRYEEIELRILLLCGSDLLESFCIPGLWNEADMEVIVGDFGIVVVPRDAADTDRIMNHSSILRKYKNNIMVVKDDINHPMSVVSSTK

--------------------------------------------------------------
>43970_43970_4_LAMC2-NMNAT2_LAMC2_chr1_183155566_ENST00000493293_NMNAT2_chr1_183262928_ENST00000294868_length(transcript)=5437nt_BP=194nt
ACCACCTGATCAAGGAAAAGGAAGGCACAGCGGAGCGCAGAGTGAGAACCACCAACCGAGGCGCCGGGCAGCGACCCCTGCAGCGGAGAC
AGAGACTGAGCGGCCCGGCCCCGCCATGCCTGCGCTCTGGCTGGGCTGCTGCCTCTGCTTCTCGCTCCTCCTGCCCGCAGCCCGGGCCAC
CTCCAGGAGGGAAGAAAGAGCCAGGGATTATCTGCACAAAACTGGAAGGTTTATTGTGATTGGCGGGATTGTCTCCCCTGTCCACGACTC
CTATGGAAAACAGGGCCTCGTGTCAAGCCGGCACCGTCTCATCATGTGTCAGCTGGCCGTCCAGAATTCTGATTGGATCAGGGTGGACCC
TTGGGAGTGCTACCAGGACACCTGGCAGACGACCTGCAGCGTGTTGGAACACCACCGGGACCTCATGAAGAGGGTGACTGGCTGCATCCT
CTCCAATGTCAACACACCTTCCATGACACCTGTGATCGGACAGCCACAAAACGAGACCCCCCAGCCCATTTACCAGAACAGCAACGTGGC
CACCAAGCCCACTGCAGCCAAGATCTTGGGGAAGGTGGGAGAAAGCCTCAGCCGGATCTGCTGTGTCCGCCCGCCGGTGGAGCGTTTCAC
CTTTGTAGATGAGAATGCCAATCTGGGCACGGTGATGCGGTATGAAGAGATTGAGCTACGGATCCTGCTGCTGTGTGGTAGTGACCTGCT
GGAGTCCTTCTGCATCCCAGGGCTCTGGAACGAGGCAGATATGGAGGTGATTGTTGGTGACTTTGGGATTGTGGTGGTGCCCCGGGATGC
AGCCGACACAGACCGAATCATGAATCACTCCTCAATACTCCGCAAATACAAAAACAACATCATGGTGGTGAAGGATGACATCAACCATCC
CATGTCTGTTGTCAGCTCAACCAAGAGCAGGCTGGCCCTGCAGCATGGGGACGGCCATGTTGTGGATTACCTGTCCCAGCCGGTCATCGA
CTACATCCTCAAAAGCCAGCTGTACATCAATGCCTCCGGCTAGCAGCCCCTCGTCCTCCGGCAACACAATGGCCCCTCCATCTTTGTCAG
CCCCCTGTTTCTCTCCTGCCTCTCTGTTTCTCCATCTCCTCGTCTTGACTGTTTTCCCTACTTGCTGACTTAACCCCCCATAGTGTGGGG
GACCTGCAGAGAACCATGGCATTCCCTATTCCACAGTCATCTTTGGACAGACTTTCCTCTAGTCTCCGGGTTGGGGGTGGGTGAGGGAAT
GGGGTGGGAGTCGGGGGAAGTGCAGTCCTTGGAGATGTACTGGTGTCCGTCTCCCAGCATGCTCTAGAGAGGCGGCTCTGGTGCCCATCC
TCCCAGCACGCTCTGGGGAGGCGGCTCTGGTGCCCATCCTCCCAGCATGCTCTAGAGAGGCGGCTCTGGTGCCCCTCCTCCCAGCATGCT
CTGGGGAGGCGGCTCTGGCTCTTGCCTTCCCAGCATGCCCTTTACTACAAAGGGCTATTTTTCTTTTCTTTCTTTTGTTTATTTATTTTT
CTTTGTTCACTCCCTGTAGAACTTGGATGAAATCAGTGTCCATGGTTCTTTATGTTTGTAGTCTTGATGTGCTCCTGTGGTATTACTTCC
CCTCTGATAGGACATTGTAGCCAGCCTCAGCACTCAGTGAGTTCATCAGGGCCACACCCAGTAGAGAAGGCCAAGCAACCTCCACTTCTT
CAGCACCACACACACGCACACACACACACACGCACACATGCGTGTGCACCCGCGCACGCACATACACACACACATATAGCAGTAGCAGCA
GCAGCAGCAGCAGCAGCAACCTTTGATCAGGAGTGAGATTTTCGGGTTCTGAAACCTGGGACACGAGTCTGTGAATAGTCGGTTTTCTCA
GAATAATTTGAATCTGTTTTCTTAGTTTCAAATGACCATTTCCCTGATGCTCTGAGCTTATGATCACACAGAGCCAGTCCATCCTCATTT
CCTGGTGGCATCTGTTCATTTACCTTTGTGGACTGTAGCTGATGGCACAGTGCGGGTTCCCTACCAGCCAGGGGTTTCCAAGGGACCTTT
GGAGGCCATGCTTAGACACATTCCTGTACCTGAGAACAACCACATAGGCAGGACCAGATCCACATCGTGCAGTCGTGTCATAAAAAAACA
AAACAAAACAAAAAAACACTAGGAGTCCACTCAACCCTGGAGGTCTTTGCTAATTGGAATTATGTATTGTCTGTTGGGCTGGGAAATGTC
TCTTTCATATTGTAAGTCCAGGATGAACTAGGAGAAAGCAATTTGTTGCCCTGATGATAACTGATGATTTTCACCCTCTCTAGCTGAGGT
AACTCAGACAGTGCATGAGGTCAGTTTCTTCTTGAGAAGCAGTGCCTTGGTCTTGTTTCTGTGGTTGGTTCTAGCCCCTGCAGAGCCTGG
GAGCTGCAGGAACTGTCTGAGAAAATCTCCCTAATAGGGGAGTGGGTTCCCAGAAGGGAGATCTGGGAGGGGTCAGGAGCCACTAAGTTG
CTTCACTCCTTTTTTCTCTAATTTTCTACCTTCCTCTCTGTTCCTGCAGACAGTTTTGCCAGCTTTGCTTCTGGTTACTAGGGTCTCATG
CGTGTCCTGCTTGGAGAGCCATAAGGAAATTGCTGTCTTGTGCTTTGTGTCTCTCATCCAGTCTCTGGCTCTTGGGATTCTGGTCTTTGA
GAAATAGTCCCTGAGTATTAGGATACTTTTATCAAAATCTAGTACCAGCTACGGCCAGAAAGGGCCAGGTGGGACCTGAAAGCAAAGACA
ATGTTCTTTACCACACGTTTCACATCTGCAACATCCTTCAATTGCGGGAAAAGGAACTTGATTTAACAGAAGAACATGGTAGAGCAGCAT
CCAGAAAGTCTGTTATTCCTCTTGGATTTTTTGAAATAATCTTCAGAGGAAGGAAGGAAAATCCTATTTTGGGGTATCAGTGTTTGACTA
GGGATCATGAAATAATAAACTGAAAAAAACTTTAGAGTTCAGTTGATCCAACACTTTCCTTTAAAAGTTGAGGGAGCAGAGGCCCATGGG
ATTAAATGGCTGGTCCAGGTCAGCCAGCAGGTGTAGGGCCTGACAAGAACATATTGTTTCCCTGACCCCTAGGCCGTCACACCACACCCT
CCATTTCCTCATGTTGCTGACCAGGTGCCCATATGATTTCTACACTTCCCAAGCCTTACCCTGGCATCTTTCTTTTAAATTATATCTGTC
CCAGGTGCTCTCCACACATAGGATGGTAATGCCAGTCCCAGGGGAGGGTGTGATAGTAAGGAAGGCCACTGTTAGGTTTCCTTTAGAAAT
AAAGAGATCTCAGCAGCTTGGAAGAAATCCCAGAAGCGGACTCCATCAATCCAAGAAAGAGTTGCTTTGTGGAAGGTGAAGGAAGACCCA
CAGAGTGCTCAGGATGATGCTATTGCTGGAGAGCGAAAGATGGAACAGCCTTGTCCAGGCAGAACAGTCATAAGCCAGGAAATGAAACAA
AGGAAAACAGGTGCCTGAATTTCCTGGGGAAACATGGCTTGTTTAAGGACTTGGAGTTATGGATGGAATTTATGGGACCCACGTGAGCAG
ACCTGAGGAAGGCTCGATTTCTTTTGTTTCTTGGTCCACTCTGTCACTCTGCTCTGGTCAAGCCCCATTTGGTCTACAGCCCATGAGAAG
GAATGAGGCTGGTTCTGCACTCTCAGCATGCAGTCCGAAAGCATGTGGGAGTGGGGAGGGAAAGTGAGATGAATTAAGACAAAGAACAGG
TGCCATAGAAGTAGATTTCTAGGAATGAAGTGGGGCAGATCTTATCTTTGTGGATTACAGGCACTGTACTAAAAACAGGTTTCCTATTTA
ATATAAAAAGAAAGTGAATCTTCTTTTGGATAGAATCATCCATTCCCATCGCCGCACCCCCTACCCCCCAAACACACACACACACACACA
CACACACACACACACACACACACACACACACGCCCTACTCTTCATTTGCTAGGGGAAGGTCACAGCACAACTAAATCCAGGACAGGACAT
TGTGACCATGACCCAGCCACAGTCAATACCAGAAAGATGATTCAGAGTCTGAAGTGGTGCCCCAGGTGCCAACAGGATAACCTCTACCCC
CCGACTTTGTCTCTGGGGTCCTGTTCCTTCCTGCAAAGCCCAATCCAAGACTGGCATGGCTCAGAGGTTGTGAGAAAGGCATGGACTGGA
ACAATCATGTCCAGAGGGGTCTGGAGCTTTGTTTCCTGTTCACCAGCAAAAAATGTCTCTCCCATTTTTCTGAAAGTGGCTGATGTAAGA
ACAGGCAGAAGGAAAACCCTTTTTGTCAATAACTCTGTCCTTAAGGAATGGTCCTCTGGGAGGGCTGTGCTGCTAGTGGGTACCTCAGTC
ACACACCCCCAACCCCAGGCAGCCTCTAGAGCCTTCTTGCTTTCATTTTCCTTGAATGTACATAGGAACAAGGGGGAAAGTCTCTTACTG
AAGTGCCTGAAACCCAAAGCTAGAGCTTCTAGAGACGCCGTTCTTCCTGTCTCAGCTTGGCCAGCCTTTCAACAATGTTCTCTAGTTTCA
AGCTCCAGCTTCTCAGAAAGAATTAAAGAACTTGCTGTTCAAATTAAGTAGAAAGTGAGACTCAATAATAACTGAACTACAGCAAAAGGC
AGAGAATTACAGGGAGAAAAAACTTGTACTTACCAGCCCAATTCTACTCTCCTCAAACTGACACACACACACACACACACACACACACAC
ACACACACACACTCTTTTAGGGGACTAAGAGAGAGAAGCATGTTATTACATTTTACTCATCCAAACAGTAATGCAAAAATAAAACGGTAG
AATATGAAAAGCTCAGGATCTCTCCCAAGGCTACCTACTGCAGGAGGGCCAACAGGTGAGATGGGAAGAATGGAAACAGGGACCGATTTT
GTAGCTCATACAATTAGGACACCTTAGGAATAGCATTGTAGTAATGGTGATGAATATGCTCTGCCAAATTCATCCAGTCTGCACCATCTT
ATAGCTGCCCAGCACACTCGACTGTTCATGTGGTCTCTTTGTAGTGTGAGTTTGGAGTGTCCTATTAGCCTGTTCTGGTTAGGAATGAGT
TAACGGCTCTTTCCCTCAACCTTAGTCTAGTCCCAGGGCTGAGGATTCAGCTGGATCCACATGGTCTTGAGGGTTGGCATGAGGAGGGGG
AAGCTTTTTTGAATCGCTTTTTGATCACATAATCTGCCATTTTAAGAGTAAGATTTGCTTTATGGAAATCAATTCATTAATAAAAAATGA
TATTCAAGTTGCAATACCATTTCACAGTGAAATATTTTGAGTACAATTTTGTTGCTAGAATAGTCATGGGCAAGAGTTTTATGCAAAATG

>43970_43970_4_LAMC2-NMNAT2_LAMC2_chr1_183155566_ENST00000493293_NMNAT2_chr1_183262928_ENST00000294868_length(amino acids)=305AA_BP=26
MPALWLGCCLCFSLLLPAARATSRREERARDYLHKTGRFIVIGGIVSPVHDSYGKQGLVSSRHRLIMCQLAVQNSDWIRVDPWECYQDTW
QTTCSVLEHHRDLMKRVTGCILSNVNTPSMTPVIGQPQNETPQPIYQNSNVATKPTAAKILGKVGESLSRICCVRPPVERFTFVDENANL
GTVMRYEEIELRILLLCGSDLLESFCIPGLWNEADMEVIVGDFGIVVVPRDAADTDRIMNHSSILRKYKNNIMVVKDDINHPMSVVSSTK

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Fusion Gene PPI Analysis for LAMC2-NMNAT2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for LAMC2-NMNAT2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for LAMC2-NMNAT2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource