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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ABI1-BIN2 (FusionGDB2 ID:440)

Fusion Gene Summary for ABI1-BIN2

check button Fusion gene summary
Fusion gene informationFusion gene name: ABI1-BIN2
Fusion gene ID: 440
HgeneTgene
Gene symbol

ABI1

BIN2

Gene ID

10006

51411

Gene nameabl interactor 1bridging integrator 2
SynonymsABI-1|ABLBP4|E3B1|NAP1BP|SSH3BP|SSH3BP1BRAP-1
Cytomap

10p12.1

12q13.13

Type of geneprotein-codingprotein-coding
Descriptionabl interactor 1Abelson interactor 1Abl-interactor protein 1 longabl-binding protein 4eps8 SH3 domain-binding proteininteractor protein AblBP4nap1 binding proteinspectrin SH3 domain-binding protein 1bridging integrator 2breast cancer associated protein BRAP1breast cancer-associated protein 1
Modification date2020032720200320
UniProtAcc

Q8IZP0

Q9UBW5

Ensembl transtripts involved in fusion geneENST00000346832, ENST00000355394, 
ENST00000359188, ENST00000376134, 
ENST00000376137, ENST00000376138, 
ENST00000376139, ENST00000376140, 
ENST00000376142, ENST00000376160, 
ENST00000376166, ENST00000376170, 
ENST00000473481, ENST00000490841, 
ENST00000536334, 		ENST00000267012, 
ENST00000452142, ENST00000604560, 
ENST00000544402, ENST00000603260, 
Fusion gene scores* DoF score15 X 10 X 8=12004 X 5 X 2=40
# samples 155
** MAII scorelog2(15/1200*10)=-3
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/40*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ABI1 [Title/Abstract] AND BIN2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointABI1(27043418)-BIN2(51674854), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneABI1

GO:0018108

peptidyl-tyrosine phosphorylation

17101133

TgeneBIN2

GO:0097320

plasma membrane tubulation

23285027


check buttonFusion gene breakpoints across ABI1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across BIN2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ABI024013ABI1chr10

27043418

-BIN2chr12

51674854

+


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Fusion Gene ORF analysis for ABI1-BIN2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000346832ENST00000267012ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-3UTRENST00000346832ENST00000452142ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-3UTRENST00000346832ENST00000604560ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-3UTRENST00000355394ENST00000267012ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-3UTRENST00000355394ENST00000452142ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-3UTRENST00000355394ENST00000604560ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-3UTRENST00000359188ENST00000267012ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-3UTRENST00000359188ENST00000452142ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-3UTRENST00000359188ENST00000604560ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-3UTRENST00000376134ENST00000267012ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-3UTRENST00000376134ENST00000452142ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-3UTRENST00000376134ENST00000604560ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-3UTRENST00000376137ENST00000267012ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-3UTRENST00000376137ENST00000452142ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-3UTRENST00000376137ENST00000604560ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-3UTRENST00000376138ENST00000267012ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-3UTRENST00000376138ENST00000452142ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-3UTRENST00000376138ENST00000604560ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-3UTRENST00000376139ENST00000267012ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-3UTRENST00000376139ENST00000452142ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-3UTRENST00000376139ENST00000604560ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-3UTRENST00000376140ENST00000267012ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-3UTRENST00000376140ENST00000452142ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-3UTRENST00000376140ENST00000604560ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-3UTRENST00000376142ENST00000267012ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-3UTRENST00000376142ENST00000452142ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-3UTRENST00000376142ENST00000604560ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-3UTRENST00000376160ENST00000267012ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-3UTRENST00000376160ENST00000452142ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-3UTRENST00000376160ENST00000604560ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-3UTRENST00000376166ENST00000267012ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-3UTRENST00000376166ENST00000452142ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-3UTRENST00000376166ENST00000604560ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-3UTRENST00000376170ENST00000267012ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-3UTRENST00000376170ENST00000452142ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-3UTRENST00000376170ENST00000604560ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-3UTRENST00000473481ENST00000267012ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-3UTRENST00000473481ENST00000452142ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-3UTRENST00000473481ENST00000604560ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-3UTRENST00000490841ENST00000267012ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-3UTRENST00000490841ENST00000452142ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-3UTRENST00000490841ENST00000604560ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-3UTRENST00000536334ENST00000267012ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-3UTRENST00000536334ENST00000452142ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-3UTRENST00000536334ENST00000604560ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-intronENST00000346832ENST00000544402ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-intronENST00000346832ENST00000603260ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-intronENST00000355394ENST00000544402ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-intronENST00000355394ENST00000603260ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-intronENST00000359188ENST00000544402ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-intronENST00000359188ENST00000603260ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-intronENST00000376134ENST00000544402ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-intronENST00000376134ENST00000603260ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-intronENST00000376137ENST00000544402ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-intronENST00000376137ENST00000603260ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-intronENST00000376138ENST00000544402ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-intronENST00000376138ENST00000603260ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-intronENST00000376139ENST00000544402ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-intronENST00000376139ENST00000603260ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-intronENST00000376140ENST00000544402ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-intronENST00000376140ENST00000603260ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-intronENST00000376142ENST00000544402ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-intronENST00000376142ENST00000603260ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-intronENST00000376160ENST00000544402ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-intronENST00000376160ENST00000603260ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-intronENST00000376166ENST00000544402ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-intronENST00000376166ENST00000603260ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-intronENST00000376170ENST00000544402ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-intronENST00000376170ENST00000603260ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-intronENST00000473481ENST00000544402ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-intronENST00000473481ENST00000603260ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-intronENST00000490841ENST00000544402ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-intronENST00000490841ENST00000603260ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-intronENST00000536334ENST00000544402ABI1chr10

27043418

-BIN2chr12

51674854

+
intron-intronENST00000536334ENST00000603260ABI1chr10

27043418

-BIN2chr12

51674854

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for ABI1-BIN2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ABI1-BIN2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:27043418/:51674854)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ABI1

Q8IZP0

BIN2

Q9UBW5

FUNCTION: May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. May play a role in regulation of EGF-induced Erk pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1/c-Abl-mediated phosphorylation of ENAH. Recruits WASF1 to lamellipodia and there seems to regulate WASF1 protein level. In brain, seems to regulate the dendritic outgrowth and branching as well as to determine the shape and number of synaptic contacts of developing neurons. {ECO:0000269|PubMed:11003655, ECO:0000269|PubMed:18328268}.FUNCTION: Promotes cell motility and migration, probably via its interaction with the cell membrane and with podosome proteins that mediate interaction with the cytoskeleton. Modulates membrane curvature and mediates membrane tubulation. Plays a role in podosome formation. Inhibits phagocytosis. {ECO:0000269|PubMed:23285027}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for ABI1-BIN2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for ABI1-BIN2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ABI1-BIN2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ABI1-BIN2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource