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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:LANCL2-SEPT14 (FusionGDB2 ID:44028)

Fusion Gene Summary for LANCL2-SEPT14

Fusion gene summary

Fusion gene information	Fusion gene name: LANCL2-SEPT14
	Fusion gene ID: 44028
		Hgene	Tgene
	Gene symbol	LANCL2	SEPT14
	Gene ID	55915	346288
	Gene name	LanC like 2	septin 14
	Synonyms	GPR69B\|TASP	SEPT14
	Cytomap	7p11.2	7p11.2
	Type of gene	protein-coding	protein-coding
	Description	lanC-like protein 2G protein-coupled receptor 69BLanC (bacterial lantibiotic synthetase component C)-like 2LanC lantibiotic synthetase component C-like 2testis-specific adriamycin sensitivity protein	septin-14
	Modification date	20200313	20200313
	UniProtAcc	Q9NS86	.
	Ensembl transtripts involved in fusion gene	ENST00000254770, ENST00000486376,	ENST00000388975, ENST00000477628,
Fusion gene scores	* DoF score	9 X 5 X 5=225	6 X 5 X 5=150
	# samples	10	13
	** MAII score	log2(10/225*10)=-1.16992500144231 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(13/150*10)=-0.206450877467426 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: LANCL2 [Title/Abstract] AND SEPT14 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	LANCL2(55479782)-SEPT14(55886916), # samples:7
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	LANCL2	GO:0009789	positive regulation of abscisic acid-activated signaling pathway	19667068
Hgene	LANCL2	GO:0045892	negative regulation of transcription, DNA-templated	12566319

Fusion gene breakpoints across LANCL2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across SEPT14 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	GBM	TCGA-06-0211-01A	LANCL2	chr7	55479782	+	SEPT14	chr7	55886916	-
ChimerDB4	GBM	TCGA-06-0211-01B	LANCL2	chr7	55479782	-	SEPT14	chr7	55886916	-
ChimerDB4	GBM	TCGA-06-0211-01B	LANCL2	chr7	55479782	+	SEPT14	chr7	55886916	-
ChimerDB4	GBM	TCGA-06-0211	LANCL2	chr7	55479782	+	SEPT14	chr7	55886916	-
ChimerDB4	GBM	TCGA-28-2513-01A	LANCL2	chr7	55433922	-	SEPT14	chr7	55914330	-
ChimerDB4	GBM	TCGA-28-2513-01A	LANCL2	chr7	55433922	+	SEPT14	chr7	55914330	-
ChimerDB4	GBM	TCGA-28-2513-01A	LANCL2	chr7	55433922	+	SEPT14	chr7	55929704	-

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Fusion Gene ORF analysis for LANCL2-SEPT14

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000254770	ENST00000388975	LANCL2	chr7	55433922	+	SEPT14	chr7	55929704	-
5CDS-5UTR	ENST00000254770	ENST00000477628	LANCL2	chr7	55433922	+	SEPT14	chr7	55914330	-
5CDS-5UTR	ENST00000254770	ENST00000477628	LANCL2	chr7	55433922	+	SEPT14	chr7	55929704	-
5CDS-intron	ENST00000254770	ENST00000477628	LANCL2	chr7	55479782	+	SEPT14	chr7	55886916	-
In-frame	ENST00000254770	ENST00000388975	LANCL2	chr7	55479782	+	SEPT14	chr7	55886916	-
In-frame	ENST00000254770	ENST00000388975	LANCL2	chr7	55433922	+	SEPT14	chr7	55914330	-
intron-3CDS	ENST00000486376	ENST00000388975	LANCL2	chr7	55479782	+	SEPT14	chr7	55886916	-
intron-3CDS	ENST00000486376	ENST00000388975	LANCL2	chr7	55433922	+	SEPT14	chr7	55914330	-
intron-5UTR	ENST00000486376	ENST00000388975	LANCL2	chr7	55433922	+	SEPT14	chr7	55929704	-
intron-5UTR	ENST00000486376	ENST00000477628	LANCL2	chr7	55433922	+	SEPT14	chr7	55914330	-
intron-5UTR	ENST00000486376	ENST00000477628	LANCL2	chr7	55433922	+	SEPT14	chr7	55929704	-
intron-intron	ENST00000486376	ENST00000477628	LANCL2	chr7	55479782	+	SEPT14	chr7	55886916	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000254770

LANCL2

chr7

55479782

ENST00000388975

SEPT14

chr7

55886916

4534

1586

545

2164

539

ENST00000254770

LANCL2

chr7

55433922

ENST00000388975

SEPT14

chr7

55914330

4396

782

545

2026

493

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000254770	ENST00000388975	LANCL2	chr7	55479782	+	SEPT14	chr7	55886916	-	0.00018205	0.999818
ENST00000254770	ENST00000388975	LANCL2	chr7	55433922	+	SEPT14	chr7	55914330	-	0.000114957	0.9998851

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Fusion Genomic Features for LANCL2-SEPT14

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for LANCL2-SEPT14

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:55479782/chr7:55886916)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
LANCL2 Q9NS86	.
FUNCTION: Necessary for abscisic acid (ABA) binding on the cell membrane and activation of the ABA signaling pathway in granulocytes. {ECO:0000269\|PubMed:19667068}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

SEPT14

chr7:55433922

chr7:55914330

ENST00000388975

332_412

433.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

SEPT14

chr7:55479782

chr7:55886916

ENST00000388975

332_412

240

433.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

SEPT14

chr7:55433922

chr7:55914330

ENST00000388975

49_315

433.0

Domain

Septin-type G

Tgene

SEPT14

chr7:55433922

chr7:55914330

ENST00000388975

195_203

433.0

Nucleotide binding

GTP

Tgene

SEPT14

chr7:55433922

chr7:55914330

ENST00000388975

111_114

433.0

Region

G3 motif

Tgene

SEPT14

chr7:55433922

chr7:55914330

ENST00000388975

194_197

433.0

Region

G4 motif

Tgene

SEPT14

chr7:55433922

chr7:55914330

ENST00000388975

59_66

433.0

Region

G1 motif

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

SEPT14

chr7:55479782

chr7:55886916

ENST00000388975

49_315

240

433.0

Domain

Septin-type G

Tgene

SEPT14

chr7:55479782

chr7:55886916

ENST00000388975

195_203

240

433.0

Nucleotide binding

GTP

Tgene

SEPT14

chr7:55479782

chr7:55886916

ENST00000388975

111_114

240

433.0

Region

G3 motif

Tgene

SEPT14

chr7:55479782

chr7:55886916

ENST00000388975

194_197

240

433.0

Region

G4 motif

Tgene

SEPT14

chr7:55479782

chr7:55886916

ENST00000388975

59_66

240

433.0

Region

G1 motif

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Fusion Gene Sequence for LANCL2-SEPT14

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>44028_44028_1_LANCL2-SEPT14_LANCL2_chr7_55433922_ENST00000254770_SEPT14_chr7_55914330_ENST00000388975_length(transcript)=4396nt_BP=782nt
GGGCTGGCGCAGCAGGGGCCGGTGAAATGCAGGCTGACGACGGCGCGCCAGGGGCTGAGCTCGCCCCGGTCGGCGACGCGCACACACCTT
GAGTGACAGCGACCTCTTCTCTACAGGTTTTCCCCGCGGGAGCGTGGCCCTAGCGGGCGTTCGGTTTTCTTTGGAAATCGCGGAGGGGGC
TGGCCGGGCGCAGCGATCCCCACCCCGGGACTCCAGCCCCGGCCGTGCGCGTCGCCGCGGACGGGCTCTGCGGGCCACGGGGAAGGTGCG
AGGAGGCGCGAGCAGGCTGTGAGCCGCTGGGCGCTCCCGCGAGCCCGCTCCTCTCCGTCGGGAGCAGGGCAAAGGCGCCAGGAACAGGGC
AGAGGCACAGCGCCCACCGCCTCTGCGGCCGCCTGATGTGCGAGCAGCCCGCGACGAGGCAGTGCACGCTCAGACGCCCCGCTCCTCCCG
CCAGCGCGCGGCCTCGCTCCTCCTAGAGGACGCTCTCTGCGCGGGCCCTCGGAGGAGGCGGCGGCGGGGCGAGCTGCAGCGCCGGGACAG
GAGGTTTGTCCCCGCCCGCGCGCCGTACCGCGGCGGAGATGGGCGAGACCATGTCAAAGAGGCTGAAGCTCCACCTGGGAGGGGAGGCAG
AAATGGAGGAACGGGCGTTCGTCAACCCCTTCCCGGACTACGAGGCCGCCGCCGGGGCGCTGCTCGCCTCCGGAGCGGCCGAAGAGACAG
GCTGTGTTCGTCCCCCGGCGACCACGGATGAGCCCGGCCTCCCTTTTCATCAGGACGGGAAGCAAAAAGAAAATAATATTCGTTGTTTAA
CTACGATTGGACATTTTGGTTTTGAATGTTTGCCCAATCAGTTGGTGAGCAGATCTATCCGACAAGGATTCACTTTTAATATTCTCTGTG
TGGGGGAGACTGGAATTGGAAAATCGACACTGATAGACACATTGTTTAATACTAACTTGAAAGATAACAAATCCTCACATTTTTACTCAA
ATGTTGGACTTCAAATTCAGACATATGAACTTCAGGAAAGCAATGTTCAGTTGAAATTGACTGTTGTGGAGACAGTAGGGTATGGTGATC
AAATAGACAAAGAAGCCAGCTACCAACCAATAGTTGACTACATAGATGCCCAATTTGAGGCCTATCTTCAAGAAGAACTGAAGATTAAAC
GTTCCTTGTTTGAGTACCATGATTCTCGCGTCCACGTGTGTCTTTACTTCATTTCACCTACAGGACATTCCCTGAAGTCTCTTGATCTAT
TAACAATGAAGAACCTTGACAGTAAGGTGAATATTATACCACTGATTGCCAAAGCAGACACTATTTCTAAAAATGATTTACAGACGTTTA
AGAATAAGATAATGAGTGAATTGATTAGCAATGGCATCCAGATATATCAGCTCCCAACAGATGAAGAAACTGCTGCTCAAGCGAACTCCT
CAGTTAGTGGGCTGTTACCCTTTGCTGTGGTAGGGAGTACAGATGAAGTGAAAGTTGGAAAAAGGATGGTCAGAGGCCGTCACTACCCTT
GGGGAGTTTTGCAAGTGGAAAATGAAAATCACTGTGACTTCGTTAAGCTCCGAGATATGCTTCTTTGTACCAATATGGAAAATCTAAAAG
AAAAAACCCACACTCAGCACTATGAATGTTATAGGTACCAAAAACTGCAGAAAATGGGCTTTACAGATGTGGGTCCAAACAACCAGCCAG
TTAGTTTTCAAGAAATCTTTGAAGCCAAAAGACAAGAGTTCTATGATCAATGTCAGAGGGAAGAAGAAGAGTTGAAACAGAGATTTATGC
AGCGAGTCAAGGAGAAAGAAGCAACATTTAAAGAAGCTGAAAAAGAGCTGCAGGACAAGTTCGAGCATCTTAAAATGATTCAACAGGAGG
AGATAAGGAAGCTCGAGGAAGAGAAAAAACAACTGGAAGGAGAAATCATAGATTTTTATAAAATGAAAGCTGCCTCCGAAGCACTGCAGA
CTCAGCTGAGCACCGATACAAAGAAAGACAAACATCGTAAGAAATAATAGTTTCTCTTACTATTCTGAGAGCCCTATCATTCTACATCGC
AACTTCCTGTGAGATTGTCTTTGTAGCATTTAACTCTGAAGTTCTCATTTTAAAAATTGGCTTGCTTATTGTATATTTTCCCCAACTAAA
GTGTGAACTCCTAGCGGGGTGTGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCGGGTGGACCACCTGAGGTCAGGAGT
TCAAAACCAGCCTGACCAAAATGATGAAACCCTGCCTCTACTAAAAATACAAAAATTAGCTGGGTTTGGTGGCCGGTACCTGTAATCCCA
GCCACTTGGGAGGCTGAGGCAGGAGAATCACTTGAACCCCGGAGGTGGAGGTTGCAGTGAGCCAAGATCTCACCATTGTACTCCAGCCTG
GGTGACAAGAGCAAAACTCCGCCTCAAAAAAAAAAAAAAAAAAAAAAGTATGAACTCCCAGAAGGCAGATCCTGTGTCCCTCTTTTCAGA
TTCTGTATCTTGGCACTTAGGACGTACACTAACACAAATATGACTTTCAATCAATATTTGCCAAAATGAAAAAACAAAAGAAACACGTAG
CATCATGTAAAAGGAGCTGGTTAGGTGGAGAAATTTATTTACCATAGTCCTGCTTTTGGATCCAGTAGTGACTTTTAACTTTTATATCCA
AATAGAAGCTGGAGGCTTTGTTGGGGACTCATAGGCATAAAATGTTAAGTTATACAAATCTAATTAATAGGCCTATTTTCCTTTTTAAGT
TCTACTACTGATAATTTCTTGACAGTTTTTATGATAAAAGGTTGGAATTTGATAAGAACTCCCATGCTTTTGTGTCAGACTTAAAACTGA
TATTAGAATAAAGAATTCAAAAGCTAGAGAAAGAGTTGCATTTGAATGATAATATTATGTGTTACAGATTTGGGGTATATGCCAAAGTTA
TCAAAGTTGTAGAAAATAAGGCCAGGTGTGGTGGCTCACACCTGTAATCCCAGCACTTTGGGAGGCCGAGGTGGGCGGATCACTTGCGGT
CAGGAGCTTGAGAACAGCCCGGCCAACATGACGAAACCCCATCTCTACTAATAATACAAAAGTTAGCCGGGTGTGGTGTTGTGCACCTGT
AGTCCCTGCTACTCGGAAAGCTGAGGCAGGAGAATCGCTTGTAGCCAGGAGGCAGAGGTTGTAGTGAGCAGAGATTGCGCCACTGCACTC
CAGCCTGGGTGACAGAGCGCTGAGTCACCACACCTGGTATAAGCCACTGTGCCTGACCCACAATGACTTTTATACATATTGTTAAATCAT
CTTACAGATTTTATAATTTGGGGGAAGAAAAATTTTACTAAATGATCTTTTAATGGAAACTCTACAAGAACCAGAATCTTTGCTTTGTTC
ACTTATGTATCCATTCCTAGGCCTAGAAAAATGTCTGACGCATAGCAGCAATTATTCATTGAATAAATGGACCCAGCAATAGTACATTAG
CTATGCCATATGCATACATTAAAAATGTAGATTATTGACTTTCAAAAGATAATTAATGTAACTTCTTACTGCTTCTGAACATGTTTGTGA
GTTATATTGCTGAGGGACCTTTATCTTCTCATTCTTTCATCTTAATCCAATGTTATTAAAACTGAAACTGAAATCACCAATATTATTCCA
TATTTAAAAATAACATCTACCTTATAAAAATTATCATTGTGCTGCATTTGAGAATAGACTTTTTAGGTAATAATGGTATAATCCATAGGG
TTTTTGAGGGCACAGAAGGATTCATGCTAACAGAACATTTTATTTTCTATTTTCCAAGAGCTATAAAACATGATATTATATGATACTATA
AGGCATATTTTTATTTTCCATAATTTTTTCTAAAAAAAATTAGTGTTGGTTTTCCATATAACTTTTAACTTTATAAGTAAATATTTGTCT
CTTTCAGCTCCAGTTTCATGTGAAATAGAGTTTCCAGATTTATGTAGCATGGAAAGTTTTAATACGTCAGTTACTGATTTTTGCCAGTCA
TTTTCTCAATTATTTACTTCTTTTATCTTTAGTTGATTTTTTTTGTAGTGACAAGTTTTGTTTCTATTCTCATTTCCTTTTGTGTATATT
CTATGTAGATTTCGTTTTTGGTTACTATGAAAATTACATATAACATCCTGGAGTTATAACATTCTGATTTGAATTTATTTCAACTTAACT
TCAATCACATACCAAAATTCTACTGCTATATAGGTCTACTCTTTTTAGGTTATTGATGTAACAAATTGTATCTTTATTCATTGTACACCA

>44028_44028_1_LANCL2-SEPT14_LANCL2_chr7_55433922_ENST00000254770_SEPT14_chr7_55914330_ENST00000388975_length(amino acids)=493AA_BP=78
MSPPARRTAAEMGETMSKRLKLHLGGEAEMEERAFVNPFPDYEAAAGALLASGAAEETGCVRPPATTDEPGLPFHQDGKQKENNIRCLTT
IGHFGFECLPNQLVSRSIRQGFTFNILCVGETGIGKSTLIDTLFNTNLKDNKSSHFYSNVGLQIQTYELQESNVQLKLTVVETVGYGDQI
DKEASYQPIVDYIDAQFEAYLQEELKIKRSLFEYHDSRVHVCLYFISPTGHSLKSLDLLTMKNLDSKVNIIPLIAKADTISKNDLQTFKN
KIMSELISNGIQIYQLPTDEETAAQANSSVSGLLPFAVVGSTDEVKVGKRMVRGRHYPWGVLQVENENHCDFVKLRDMLLCTNMENLKEK
THTQHYECYRYQKLQKMGFTDVGPNNQPVSFQEIFEAKRQEFYDQCQREEEELKQRFMQRVKEKEATFKEAEKELQDKFEHLKMIQQEEI

--------------------------------------------------------------
>44028_44028_2_LANCL2-SEPT14_LANCL2_chr7_55479782_ENST00000254770_SEPT14_chr7_55886916_ENST00000388975_length(transcript)=4534nt_BP=1586nt
GGGCTGGCGCAGCAGGGGCCGGTGAAATGCAGGCTGACGACGGCGCGCCAGGGGCTGAGCTCGCCCCGGTCGGCGACGCGCACACACCTT
GAGTGACAGCGACCTCTTCTCTACAGGTTTTCCCCGCGGGAGCGTGGCCCTAGCGGGCGTTCGGTTTTCTTTGGAAATCGCGGAGGGGGC
TGGCCGGGCGCAGCGATCCCCACCCCGGGACTCCAGCCCCGGCCGTGCGCGTCGCCGCGGACGGGCTCTGCGGGCCACGGGGAAGGTGCG
AGGAGGCGCGAGCAGGCTGTGAGCCGCTGGGCGCTCCCGCGAGCCCGCTCCTCTCCGTCGGGAGCAGGGCAAAGGCGCCAGGAACAGGGC
AGAGGCACAGCGCCCACCGCCTCTGCGGCCGCCTGATGTGCGAGCAGCCCGCGACGAGGCAGTGCACGCTCAGACGCCCCGCTCCTCCCG
CCAGCGCGCGGCCTCGCTCCTCCTAGAGGACGCTCTCTGCGCGGGCCCTCGGAGGAGGCGGCGGCGGGGCGAGCTGCAGCGCCGGGACAG
GAGGTTTGTCCCCGCCCGCGCGCCGTACCGCGGCGGAGATGGGCGAGACCATGTCAAAGAGGCTGAAGCTCCACCTGGGAGGGGAGGCAG
AAATGGAGGAACGGGCGTTCGTCAACCCCTTCCCGGACTACGAGGCCGCCGCCGGGGCGCTGCTCGCCTCCGGAGCGGCCGAAGAGACAG
GCTGTGTTCGTCCCCCGGCGACCACGGATGAGCCCGGCCTCCCTTTTCATCAGGACGGGAAGATCATTCATAATTTCATAAGACGGATCC
AGACCAAAATTAAAGATCTTCTGCAGCAAATGGAAGAAGGGCTGAAGACAGCTGATCCCCATGACTGCTCTGCTTATACTGGCTGGACAG
GCATAGCCCTTTTGTACCTGCAGTTGTACCGGGTCACATGTGACCAAACCTACCTGCTCCGATCCCTGGATTACGTAAAAAGAACACTTC
GGAATCTGAATGGCCGCAGGGTCACCTTCCTCTGTGGGGATGCTGGCCCCCTGGCTGTTGGAGCTGTGATTTATCACAAACTCAGAAGTG
ACTGTGAGTCCCAGGAATGTGTCACAAAACTTTTGCAGCTCCAGAGATCGGTTGTCTGCCAAGAATCAGACCTTCCTGATGAGCTGCTTT
ATGGACGGGCAGGTTATCTGTATGCCTTACTGTACCTGAACACAGAGATAGGTCCAGGCACCGTGTGTGAGTCAGCTATTAAAGAGGTAG
TCAATGCTATTATTGAATCGGGTAAGACTTTGTCAAGGGAAGAAAGAAAAACGGAGCGCTGCCCGCTGTTGTACCAGTGGCACCGGAAGC
AGTACGTTGGAGCAGCCCATGGCATGGCTGGAATTTACTATATGTTAATGCAGCCGGCAGCAAAAGTGGACCAAGAAACCTTGACAGAAA
TGGTGAAACCCAGTATTGATTATGTGCGCCACAAAAAATTCCGATCTGGGAATTACCCATCATCATTAAGCAATGAAACAGACCGGCTGG
TGCACTGGTGCCACGGCGCCCCGGGGGTCATCCACATGCTCATGCAGGCGTACAAGGGGCTGTTACCCTTTGCTGTGGTAGGGAGTACAG
ATGAAGTGAAAGTTGGAAAAAGGATGGTCAGAGGCCGTCACTACCCTTGGGGAGTTTTGCAAGTGGAAAATGAAAATCACTGTGACTTCG
TTAAGCTCCGAGATATGCTTCTTTGTACCAATATGGAAAATCTAAAAGAAAAAACCCACACTCAGCACTATGAATGTTATAGGTACCAAA
AACTGCAGAAAATGGGCTTTACAGATGTGGGTCCAAACAACCAGCCAGTTAGTTTTCAAGAAATCTTTGAAGCCAAAAGACAAGAGTTCT
ATGATCAATGTCAGAGGGAAGAAGAAGAGTTGAAACAGAGATTTATGCAGCGAGTCAAGGAGAAAGAAGCAACATTTAAAGAAGCTGAAA
AAGAGCTGCAGGACAAGTTCGAGCATCTTAAAATGATTCAACAGGAGGAGATAAGGAAGCTCGAGGAAGAGAAAAAACAACTGGAAGGAG
AAATCATAGATTTTTATAAAATGAAAGCTGCCTCCGAAGCACTGCAGACTCAGCTGAGCACCGATACAAAGAAAGACAAACATCGTAAGA
AATAATAGTTTCTCTTACTATTCTGAGAGCCCTATCATTCTACATCGCAACTTCCTGTGAGATTGTCTTTGTAGCATTTAACTCTGAAGT
TCTCATTTTAAAAATTGGCTTGCTTATTGTATATTTTCCCCAACTAAAGTGTGAACTCCTAGCGGGGTGTGGTGGCTCATGCCTGTAATC
CCAGCACTTTGGGAGGCTGAGGCGGGTGGACCACCTGAGGTCAGGAGTTCAAAACCAGCCTGACCAAAATGATGAAACCCTGCCTCTACT
AAAAATACAAAAATTAGCTGGGTTTGGTGGCCGGTACCTGTAATCCCAGCCACTTGGGAGGCTGAGGCAGGAGAATCACTTGAACCCCGG
AGGTGGAGGTTGCAGTGAGCCAAGATCTCACCATTGTACTCCAGCCTGGGTGACAAGAGCAAAACTCCGCCTCAAAAAAAAAAAAAAAAA
AAAAAGTATGAACTCCCAGAAGGCAGATCCTGTGTCCCTCTTTTCAGATTCTGTATCTTGGCACTTAGGACGTACACTAACACAAATATG
ACTTTCAATCAATATTTGCCAAAATGAAAAAACAAAAGAAACACGTAGCATCATGTAAAAGGAGCTGGTTAGGTGGAGAAATTTATTTAC
CATAGTCCTGCTTTTGGATCCAGTAGTGACTTTTAACTTTTATATCCAAATAGAAGCTGGAGGCTTTGTTGGGGACTCATAGGCATAAAA
TGTTAAGTTATACAAATCTAATTAATAGGCCTATTTTCCTTTTTAAGTTCTACTACTGATAATTTCTTGACAGTTTTTATGATAAAAGGT
TGGAATTTGATAAGAACTCCCATGCTTTTGTGTCAGACTTAAAACTGATATTAGAATAAAGAATTCAAAAGCTAGAGAAAGAGTTGCATT
TGAATGATAATATTATGTGTTACAGATTTGGGGTATATGCCAAAGTTATCAAAGTTGTAGAAAATAAGGCCAGGTGTGGTGGCTCACACC
TGTAATCCCAGCACTTTGGGAGGCCGAGGTGGGCGGATCACTTGCGGTCAGGAGCTTGAGAACAGCCCGGCCAACATGACGAAACCCCAT
CTCTACTAATAATACAAAAGTTAGCCGGGTGTGGTGTTGTGCACCTGTAGTCCCTGCTACTCGGAAAGCTGAGGCAGGAGAATCGCTTGT
AGCCAGGAGGCAGAGGTTGTAGTGAGCAGAGATTGCGCCACTGCACTCCAGCCTGGGTGACAGAGCGCTGAGTCACCACACCTGGTATAA
GCCACTGTGCCTGACCCACAATGACTTTTATACATATTGTTAAATCATCTTACAGATTTTATAATTTGGGGGAAGAAAAATTTTACTAAA
TGATCTTTTAATGGAAACTCTACAAGAACCAGAATCTTTGCTTTGTTCACTTATGTATCCATTCCTAGGCCTAGAAAAATGTCTGACGCA
TAGCAGCAATTATTCATTGAATAAATGGACCCAGCAATAGTACATTAGCTATGCCATATGCATACATTAAAAATGTAGATTATTGACTTT
CAAAAGATAATTAATGTAACTTCTTACTGCTTCTGAACATGTTTGTGAGTTATATTGCTGAGGGACCTTTATCTTCTCATTCTTTCATCT
TAATCCAATGTTATTAAAACTGAAACTGAAATCACCAATATTATTCCATATTTAAAAATAACATCTACCTTATAAAAATTATCATTGTGC
TGCATTTGAGAATAGACTTTTTAGGTAATAATGGTATAATCCATAGGGTTTTTGAGGGCACAGAAGGATTCATGCTAACAGAACATTTTA
TTTTCTATTTTCCAAGAGCTATAAAACATGATATTATATGATACTATAAGGCATATTTTTATTTTCCATAATTTTTTCTAAAAAAAATTA
GTGTTGGTTTTCCATATAACTTTTAACTTTATAAGTAAATATTTGTCTCTTTCAGCTCCAGTTTCATGTGAAATAGAGTTTCCAGATTTA
TGTAGCATGGAAAGTTTTAATACGTCAGTTACTGATTTTTGCCAGTCATTTTCTCAATTATTTACTTCTTTTATCTTTAGTTGATTTTTT
TTGTAGTGACAAGTTTTGTTTCTATTCTCATTTCCTTTTGTGTATATTCTATGTAGATTTCGTTTTTGGTTACTATGAAAATTACATATA
ACATCCTGGAGTTATAACATTCTGATTTGAATTTATTTCAACTTAACTTCAATCACATACCAAAATTCTACTGCTATATAGGTCTACTCT
TTTTAGGTTATTGATGTAACAAATTGTATCTTTATTCATTGTACACCACCTAACAGATTTATAATTACATTTTATGCATTTGTCTTTTAA

>44028_44028_2_LANCL2-SEPT14_LANCL2_chr7_55479782_ENST00000254770_SEPT14_chr7_55886916_ENST00000388975_length(amino acids)=539AA_BP=347
MSPPARRTAAEMGETMSKRLKLHLGGEAEMEERAFVNPFPDYEAAAGALLASGAAEETGCVRPPATTDEPGLPFHQDGKIIHNFIRRIQT
KIKDLLQQMEEGLKTADPHDCSAYTGWTGIALLYLQLYRVTCDQTYLLRSLDYVKRTLRNLNGRRVTFLCGDAGPLAVGAVIYHKLRSDC
ESQECVTKLLQLQRSVVCQESDLPDELLYGRAGYLYALLYLNTEIGPGTVCESAIKEVVNAIIESGKTLSREERKTERCPLLYQWHRKQY
VGAAHGMAGIYYMLMQPAAKVDQETLTEMVKPSIDYVRHKKFRSGNYPSSLSNETDRLVHWCHGAPGVIHMLMQAYKGLLPFAVVGSTDE
VKVGKRMVRGRHYPWGVLQVENENHCDFVKLRDMLLCTNMENLKEKTHTQHYECYRYQKLQKMGFTDVGPNNQPVSFQEIFEAKRQEFYD

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Fusion Gene PPI Analysis for LANCL2-SEPT14

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Still interaction with
Hgene	LANCL2	chr7:55433922	chr7:55914330	ENST00000254770	+	1	9	2_15	68.0	451.0	inositol phospholipids
Hgene	LANCL2	chr7:55479782	chr7:55886916	ENST00000254770	+	6	9	2_15	336.0	451.0	inositol phospholipids

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for LANCL2-SEPT14

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for LANCL2-SEPT14

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source