Home

Download

Statistics

Examples

Help

Contact

	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:LAP3-DDX1 (FusionGDB2 ID:44034)

Fusion Gene Summary for LAP3-DDX1

Fusion gene summary

Fusion gene information	Fusion gene name: LAP3-DDX1
	Fusion gene ID: 44034
		Hgene	Tgene
	Gene symbol	LAP3	DDX1
	Gene ID	51056	1653
	Gene name	leucine aminopeptidase 3	DEAD-box helicase 1
	Synonyms	HEL-S-106\|LAP\|LAPEP\|PEPS	DBP-RB\|UKVH5d
	Cytomap	4p15.32	2p24.3
	Type of gene	protein-coding	protein-coding
	Description	cytosol aminopeptidaseLAP-3epididymis secretory protein Li 106leucyl aminopeptidasepeptidase Sproline aminopeptidaseprolyl aminopeptidase	ATP-dependent RNA helicase DDX1DEAD (Asp-Glu-Ala-Asp) box helicase 1DEAD (Asp-Glu-Ala-Asp) box polypeptide 1DEAD box polypeptide 1DEAD box protein 1DEAD box protein retinoblastomaDEAD box-1DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 1DEAD/H-box h
	Modification date	20200313	20200313
	UniProtAcc	P28838	Q9UMR2
	Ensembl transtripts involved in fusion gene	ENST00000226299, ENST00000606142, ENST00000503467,	ENST00000233084, ENST00000381341,
Fusion gene scores	* DoF score	4 X 4 X 3=48	4 X 5 X 3=60
	# samples	5	5
	** MAII score	log2(5/48*10)=0.0588936890535686 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: LAP3 [Title/Abstract] AND DDX1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	LAP3(17583437)-DDX1(15746274), # samples:3
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	DDX1	GO:0006302	double-strand break repair	18710941
Tgene	DDX1	GO:0032508	DNA duplex unwinding	18710941
Tgene	DDX1	GO:0090305	nucleic acid phosphodiester bond hydrolysis	18710941

Fusion gene breakpoints across LAP3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across DDX1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BLCA	TCGA-G2-A2EF-01A	LAP3	chr4	17583437	-	DDX1	chr2	15746274	+
ChimerDB4	BLCA	TCGA-G2-A2EF-01A	LAP3	chr4	17583437	+	DDX1	chr2	15746274	+
ChimerDB4	BLCA	TCGA-G2-A2EF	LAP3	chr4	17583437	+	DDX1	chr2	15746273	+

Top

Fusion Gene ORF analysis for LAP3-DDX1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000226299	ENST00000233084	LAP3	chr4	17583437	+	DDX1	chr2	15746274	+
In-frame	ENST00000226299	ENST00000233084	LAP3	chr4	17583437	+	DDX1	chr2	15746273	+
In-frame	ENST00000226299	ENST00000381341	LAP3	chr4	17583437	+	DDX1	chr2	15746274	+
In-frame	ENST00000226299	ENST00000381341	LAP3	chr4	17583437	+	DDX1	chr2	15746273	+
In-frame	ENST00000606142	ENST00000233084	LAP3	chr4	17583437	+	DDX1	chr2	15746274	+
In-frame	ENST00000606142	ENST00000233084	LAP3	chr4	17583437	+	DDX1	chr2	15746273	+
In-frame	ENST00000606142	ENST00000381341	LAP3	chr4	17583437	+	DDX1	chr2	15746274	+
In-frame	ENST00000606142	ENST00000381341	LAP3	chr4	17583437	+	DDX1	chr2	15746273	+
intron-3CDS	ENST00000503467	ENST00000233084	LAP3	chr4	17583437	+	DDX1	chr2	15746274	+
intron-3CDS	ENST00000503467	ENST00000233084	LAP3	chr4	17583437	+	DDX1	chr2	15746273	+
intron-3CDS	ENST00000503467	ENST00000381341	LAP3	chr4	17583437	+	DDX1	chr2	15746274	+
intron-3CDS	ENST00000503467	ENST00000381341	LAP3	chr4	17583437	+	DDX1	chr2	15746273	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000226299	LAP3	chr4	17583437	+	ENST00000381341	DDX1	chr2	15746274	+	2273	547	184	2067	627
ENST00000226299	LAP3	chr4	17583437	+	ENST00000233084	DDX1	chr2	15746274	+	2263	547	184	2067	627
ENST00000606142	LAP3	chr4	17583437	+	ENST00000381341	DDX1	chr2	15746274	+	1970	244	19	1764	581
ENST00000606142	LAP3	chr4	17583437	+	ENST00000233084	DDX1	chr2	15746274	+	1960	244	19	1764	581
ENST00000226299	LAP3	chr4	17583437	+	ENST00000381341	DDX1	chr2	15746273	+	2273	547	184	2067	627
ENST00000226299	LAP3	chr4	17583437	+	ENST00000233084	DDX1	chr2	15746273	+	2263	547	184	2067	627
ENST00000606142	LAP3	chr4	17583437	+	ENST00000381341	DDX1	chr2	15746273	+	1970	244	19	1764	581
ENST00000606142	LAP3	chr4	17583437	+	ENST00000233084	DDX1	chr2	15746273	+	1960	244	19	1764	581

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000226299	ENST00000381341	LAP3	chr4	17583437	+	DDX1	chr2	15746274	+	0.000629676	0.9993704
ENST00000226299	ENST00000233084	LAP3	chr4	17583437	+	DDX1	chr2	15746274	+	0.000610711	0.9993893
ENST00000606142	ENST00000381341	LAP3	chr4	17583437	+	DDX1	chr2	15746274	+	0.000636292	0.9993637
ENST00000606142	ENST00000233084	LAP3	chr4	17583437	+	DDX1	chr2	15746274	+	0.000620971	0.99937904
ENST00000226299	ENST00000381341	LAP3	chr4	17583437	+	DDX1	chr2	15746273	+	0.000629676	0.9993704
ENST00000226299	ENST00000233084	LAP3	chr4	17583437	+	DDX1	chr2	15746273	+	0.000610711	0.9993893
ENST00000606142	ENST00000381341	LAP3	chr4	17583437	+	DDX1	chr2	15746273	+	0.000636292	0.9993637
ENST00000606142	ENST00000233084	LAP3	chr4	17583437	+	DDX1	chr2	15746273	+	0.000620971	0.99937904

Top

Fusion Genomic Features for LAP3-DDX1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
LAP3	chr4	17583437	+	DDX1	chr2	15746273	+	0.001819627	0.9981804
LAP3	chr4	17583437	+	DDX1	chr2	15746273	+	0.001819627	0.9981804
LAP3	chr4	17583437	+	DDX1	chr2	15746273	+	0.001819627	0.9981804
LAP3	chr4	17583437	+	DDX1	chr2	15746273	+	0.001819627	0.9981804

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for LAP3-DDX1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr4:17583437/chr2:15746274)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
LAP3 P28838	DDX1 Q9UMR2
FUNCTION: Cytolosic metallopeptidase that catalyzes the removal of unsubstituted N-terminal hydrophobic amino acids from various peptides. The presence of Zn(2+) ions is essential for the peptidase activity, and the association with other cofactors can modulate the substrate spectificity of the enzyme. For instance, in the presence of Mn(2+), it displays a specific Cys-Gly hydrolyzing activity of Cys-Gly-S-conjugates. Involved in the metabolism of glutathione and in the degradation of glutathione S-conjugates, which may play a role in the control of the cell redox status. {ECO:0000250\|UniProtKB:P00727}.	FUNCTION: ATP-dependent RNA helicase involved in mRNA export from the nucleus (PubMed:10428971). Rather than unwinding RNA duplexes, DDX19B functions as a remodeler of ribonucleoprotein particles, whereby proteins bound to nuclear mRNA are dissociated and replaced by cytoplasmic mRNA binding proteins (PubMed:10428971). {ECO:0000269\|PubMed:10428971}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

DDX1

chr4:17583437

chr2:15746273

ENST00000233084

493_681

234

741.0

Domain

Helicase C-terminal

Tgene

DDX1

chr4:17583437

chr2:15746273

ENST00000381341

493_681

234

741.0

Domain

Helicase C-terminal

Tgene

DDX1

chr4:17583437

chr2:15746274

ENST00000233084

493_681

234

741.0

Domain

Helicase C-terminal

Tgene

DDX1

chr4:17583437

chr2:15746274

ENST00000381341

493_681

234

741.0

Domain

Helicase C-terminal

Tgene

DDX1

chr4:17583437

chr2:15746273

ENST00000233084

370_373

234

741.0

Motif

DEAD box

Tgene

DDX1

chr4:17583437

chr2:15746273

ENST00000381341

370_373

234

741.0

Motif

DEAD box

Tgene

DDX1

chr4:17583437

chr2:15746274

ENST00000233084

370_373

234

741.0

Motif

DEAD box

Tgene

DDX1

chr4:17583437

chr2:15746274

ENST00000381341

370_373

234

741.0

Motif

DEAD box

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

DDX1

chr4:17583437

chr2:15746273

ENST00000233084

2_428

234

741.0

Domain

Helicase ATP-binding

Tgene

DDX1

chr4:17583437

chr2:15746273

ENST00000233084

70_247

234

741.0

Domain

B30.2/SPRY

Tgene

DDX1

chr4:17583437

chr2:15746273

ENST00000381341

2_428

234

741.0

Domain

Helicase ATP-binding

Tgene

DDX1

chr4:17583437

chr2:15746273

ENST00000381341

70_247

234

741.0

Domain

B30.2/SPRY

Tgene

DDX1

chr4:17583437

chr2:15746274

ENST00000233084

2_428

234

741.0

Domain

Helicase ATP-binding

Tgene

DDX1

chr4:17583437

chr2:15746274

ENST00000233084

70_247

234

741.0

Domain

B30.2/SPRY

Tgene

DDX1

chr4:17583437

chr2:15746274

ENST00000381341

2_428

234

741.0

Domain

Helicase ATP-binding

Tgene

DDX1

chr4:17583437

chr2:15746274

ENST00000381341

70_247

234

741.0

Domain

B30.2/SPRY

Tgene

DDX1

chr4:17583437

chr2:15746273

ENST00000233084

46_53

234

741.0

Nucleotide binding

ATP

Tgene

DDX1

chr4:17583437

chr2:15746273

ENST00000381341

46_53

234

741.0

Nucleotide binding

ATP

Tgene

DDX1

chr4:17583437

chr2:15746274

ENST00000233084

46_53

234

741.0

Nucleotide binding

ATP

Tgene

DDX1

chr4:17583437

chr2:15746274

ENST00000381341

46_53

234

741.0

Nucleotide binding

ATP

Top

Fusion Gene Sequence for LAP3-DDX1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>44034_44034_1_LAP3-DDX1_LAP3_chr4_17583437_ENST00000226299_DDX1_chr2_15746273_ENST00000233084_length(transcript)=2263nt_BP=547nt
GCGGGCGCACACGAATGCGGGCGCACACGAATGCGGGCGCACACGAATGCGGGCGCACCCTTGAGTCCCCTCCACAACCGCGGTTTGATC
CCAGCGGTCCAGTCGGCCGGTGCTGCCCATCCGTCCCGCCCCCTAGACGCACGTCCGCTCGCCCGGCGCCCGAGCCAGTCCGCGCGCACG
CCGTCTGCGCCCCGAAAGCCCCGCCCCAAGGCGCGCCCGCCCACCGCTCTCCACGTGCTCGCTGGAGGGCGGTGCGAGGGGCCGAGCCGA
CAAGATGTTCTTGCTGCCTCTTCCGGCTGCGGGGCGAGTAGTCGTCCGACGTCTGGCCGTGAGACGTTTCGGGAGCCGGAGTCTCTCCAC
CGCAGACATGACGAAGGGCCTTGTTTTAGGAATCTATTCCAAAGAAAAAGAAGATGATGTGCCACAGTTCACAAGTGCAGGAGAGAATTT
TGATAAATTGTTAGCTGGAAAGCTGAGAGAGACTTTGAACATATCTGGACCACCTCTGAAGGCAGGGAAGACTCGAACCTTTTATGGTCT
GCATCAGAATGCTGAACTGAAATTTAACTTCGGTGAAGAGGAATTTAAGTTTCCACCAAAAGATGGCTTTGTTGCTCTTTCCAAGGCACC
GGATGGTTACATTGTCAAATCACAGCACTCAGGTAATGCACAGGTGACACAAACAAAGTTTCTCCCCAATGCTCCGAAAGCTCTCATTGT
TGAACCTTCCCGGGAGTTAGCTGAACAAACTTTGAACAACATCAAGCAGTTTAAGAAATACATTGATAATCCTAAATTAAGGGAGCTTCT
GATAATTGGAGGTGTTGCAGCCCGGGATCAGCTCTCTGTTTTGGAAAATGGAGTAGATATAGTTGTAGGTACTCCGGGAAGACTAGATGA
CTTGGTGTCAACTGGAAAGCTGAACTTATCTCAAGTTAGATTCCTGGTCCTGGATGAAGCTGATGGGCTTCTTTCTCAAGGTTATTCTGA
TTTTATAAATAGGATGCACAATCAGATTCCTCAGGTTACCTCTGATGGAAAAAGACTTCAGGTGATTGTTTGCTCTGCCACTTTGCATTC
TTTCGATGTAAAGAAACTGTCCGAGAAGATAATGCATTTTCCTACATGGGTTGACTTAAAAGGAGAAGACTCTGTTCCAGATACTGTACA
CCATGTTGTTGTCCCAGTAAATCCCAAAACTGACAGACTCTGGGAAAGGCTTGGAAAGAGCCACATTAGAACTGATGATGTACATGCAAA
AGATAACACAAGACCTGGTGCTAATAGTCCAGAGATGTGGTCTGAAGCTATTAAAATCCTGAAAGGGGAGTATGCTGTCCGGGCAATCAA
GGAACATAAGATGGATCAAGCAATTATCTTCTGTAGAACCAAAATTGACTGTGATAACTTGGAGCAGTACTTTATACAACAAGGAGGAGG
ACCTGATAAAAAAGGACACCAGTTCTCATGTGTTTGTCTTCATGGTGACAGAAAGCCTCATGAGAGAAAGCAAAACTTGGAAAGATTTAA
GAAAGGAGATGTAAGATTCTTGATTTGCACAGATGTAGCTGCTAGAGGAATTGATATCCACGGTGTTCCTTATGTTATAAATGTCACTCT
GCCCGATGAAAAGCAAAACTACGTACATCGAATTGGCAGAGTAGGAAGAGCTGAAAGGATGGGTCTGGCAATTTCCCTGGTGGCAACAGA
AAAAGAAAAGGTTTGGTACCATGTATGTAGCAGCCGTGGAAAAGGGTGTTATAACACAAGACTCAAGGAAGATGGAGGCTGTACCATATG
GTACAACGAGATGCAGTTACTATCTGAGATAGAAGAACACCTGAACTGTACCATTTCTCAGGTTGAGCCGGATATAAAGGTACCAGTGGA
TGAATTTGATGGGAAAGTTACCTACGGTCAGAAAAGGGCTGCTGGTGGTGGAAGCTATAAAGGCCATGTGGATATTTTGGCACCTACTGT
TCAAGAGTTGGCTGCCCTTGAAAAGGAGGCGCAGACATCTTTCCTGCATCTTGGCTACCTTCCTAACCAGCTGTTCAGAACCTTCTGATT
TTTACATTTACTGAATAAGATTTGAGTAATGAAAGTCTGTAGTCTTAAAACTCTAAAACAGTTGTACTGCTTCCAAGCAGCAGTATTTAT
AGTAACGTAAGCTATTAATGCTAACTCTTGCATGTCAAGAAACATTAGTCTTAGGAATTCTTCAAAAAATGGCATCCCAATGAAAATAAA

>44034_44034_1_LAP3-DDX1_LAP3_chr4_17583437_ENST00000226299_DDX1_chr2_15746273_ENST00000233084_length(amino acids)=627AA_BP=121
MRPESPAPRRARPPLSTCSLEGGARGRADKMFLLPLPAAGRVVVRRLAVRRFGSRSLSTADMTKGLVLGIYSKEKEDDVPQFTSAGENFD
KLLAGKLRETLNISGPPLKAGKTRTFYGLHQNAELKFNFGEEEFKFPPKDGFVALSKAPDGYIVKSQHSGNAQVTQTKFLPNAPKALIVE
PSRELAEQTLNNIKQFKKYIDNPKLRELLIIGGVAARDQLSVLENGVDIVVGTPGRLDDLVSTGKLNLSQVRFLVLDEADGLLSQGYSDF
INRMHNQIPQVTSDGKRLQVIVCSATLHSFDVKKLSEKIMHFPTWVDLKGEDSVPDTVHHVVVPVNPKTDRLWERLGKSHIRTDDVHAKD
NTRPGANSPEMWSEAIKILKGEYAVRAIKEHKMDQAIIFCRTKIDCDNLEQYFIQQGGGPDKKGHQFSCVCLHGDRKPHERKQNLERFKK
GDVRFLICTDVAARGIDIHGVPYVINVTLPDEKQNYVHRIGRVGRAERMGLAISLVATEKEKVWYHVCSSRGKGCYNTRLKEDGGCTIWY

--------------------------------------------------------------
>44034_44034_2_LAP3-DDX1_LAP3_chr4_17583437_ENST00000226299_DDX1_chr2_15746273_ENST00000381341_length(transcript)=2273nt_BP=547nt
GCGGGCGCACACGAATGCGGGCGCACACGAATGCGGGCGCACACGAATGCGGGCGCACCCTTGAGTCCCCTCCACAACCGCGGTTTGATC
CCAGCGGTCCAGTCGGCCGGTGCTGCCCATCCGTCCCGCCCCCTAGACGCACGTCCGCTCGCCCGGCGCCCGAGCCAGTCCGCGCGCACG
CCGTCTGCGCCCCGAAAGCCCCGCCCCAAGGCGCGCCCGCCCACCGCTCTCCACGTGCTCGCTGGAGGGCGGTGCGAGGGGCCGAGCCGA
CAAGATGTTCTTGCTGCCTCTTCCGGCTGCGGGGCGAGTAGTCGTCCGACGTCTGGCCGTGAGACGTTTCGGGAGCCGGAGTCTCTCCAC
CGCAGACATGACGAAGGGCCTTGTTTTAGGAATCTATTCCAAAGAAAAAGAAGATGATGTGCCACAGTTCACAAGTGCAGGAGAGAATTT
TGATAAATTGTTAGCTGGAAAGCTGAGAGAGACTTTGAACATATCTGGACCACCTCTGAAGGCAGGGAAGACTCGAACCTTTTATGGTCT
GCATCAGAATGCTGAACTGAAATTTAACTTCGGTGAAGAGGAATTTAAGTTTCCACCAAAAGATGGCTTTGTTGCTCTTTCCAAGGCACC
GGATGGTTACATTGTCAAATCACAGCACTCAGGTAATGCACAGGTGACACAAACAAAGTTTCTCCCCAATGCTCCGAAAGCTCTCATTGT
TGAACCTTCCCGGGAGTTAGCTGAACAAACTTTGAACAACATCAAGCAGTTTAAGAAATACATTGATAATCCTAAATTAAGGGAGCTTCT
GATAATTGGAGGTGTTGCAGCCCGGGATCAGCTCTCTGTTTTGGAAAATGGAGTAGATATAGTTGTAGGTACTCCGGGAAGACTAGATGA
CTTGGTGTCAACTGGAAAGCTGAACTTATCTCAAGTTAGATTCCTGGTCCTGGATGAAGCTGATGGGCTTCTTTCTCAAGGTTATTCTGA
TTTTATAAATAGGATGCACAATCAGATTCCTCAGGTTACCTCTGATGGAAAAAGACTTCAGGTGATTGTTTGCTCTGCCACTTTGCATTC
TTTCGATGTAAAGAAACTGTCCGAGAAGATAATGCATTTTCCTACATGGGTTGACTTAAAAGGAGAAGACTCTGTTCCAGATACTGTACA
CCATGTTGTTGTCCCAGTAAATCCCAAAACTGACAGACTCTGGGAAAGGCTTGGAAAGAGCCACATTAGAACTGATGATGTACATGCAAA
AGATAACACAAGACCTGGTGCTAATAGTCCAGAGATGTGGTCTGAAGCTATTAAAATCCTGAAAGGGGAGTATGCTGTCCGGGCAATCAA
GGAACATAAGATGGATCAAGCAATTATCTTCTGTAGAACCAAAATTGACTGTGATAACTTGGAGCAGTACTTTATACAACAAGGAGGAGG
ACCTGATAAAAAAGGACACCAGTTCTCATGTGTTTGTCTTCATGGTGACAGAAAGCCTCATGAGAGAAAGCAAAACTTGGAAAGATTTAA
GAAAGGAGATGTAAGATTCTTGATTTGCACAGATGTAGCTGCTAGAGGAATTGATATCCACGGTGTTCCTTATGTTATAAATGTCACTCT
GCCCGATGAAAAGCAAAACTACGTACATCGAATTGGCAGAGTAGGAAGAGCTGAAAGGATGGGTCTGGCAATTTCCCTGGTGGCAACAGA
AAAAGAAAAGGTTTGGTACCATGTATGTAGCAGCCGTGGAAAAGGGTGTTATAACACAAGACTCAAGGAAGATGGAGGCTGTACCATATG
GTACAACGAGATGCAGTTACTATCTGAGATAGAAGAACACCTGAACTGTACCATTTCTCAGGTTGAGCCGGATATAAAGGTACCAGTGGA
TGAATTTGATGGGAAAGTTACCTACGGTCAGAAAAGGGCTGCTGGTGGTGGAAGCTATAAAGGCCATGTGGATATTTTGGCACCTACTGT
TCAAGAGTTGGCTGCCCTTGAAAAGGAGGCGCAGACATCTTTCCTGCATCTTGGCTACCTTCCTAACCAGCTGTTCAGAACCTTCTGATT
TTTACATTTACTGAATAAGATTTGAGTAATGAAAGTCTGTAGTCTTAAAACTCTAAAACAGTTGTACTGCTTCCAAGCAGCAGTATTTAT
AGTAACGTAAGCTATTAATGCTAACTCTTGCATGTCAAGAAACATTAGTCTTAGGAATTCTTCAAAAAATGGCATCCCAATGAAAATAAA

>44034_44034_2_LAP3-DDX1_LAP3_chr4_17583437_ENST00000226299_DDX1_chr2_15746273_ENST00000381341_length(amino acids)=627AA_BP=121
MRPESPAPRRARPPLSTCSLEGGARGRADKMFLLPLPAAGRVVVRRLAVRRFGSRSLSTADMTKGLVLGIYSKEKEDDVPQFTSAGENFD
KLLAGKLRETLNISGPPLKAGKTRTFYGLHQNAELKFNFGEEEFKFPPKDGFVALSKAPDGYIVKSQHSGNAQVTQTKFLPNAPKALIVE
PSRELAEQTLNNIKQFKKYIDNPKLRELLIIGGVAARDQLSVLENGVDIVVGTPGRLDDLVSTGKLNLSQVRFLVLDEADGLLSQGYSDF
INRMHNQIPQVTSDGKRLQVIVCSATLHSFDVKKLSEKIMHFPTWVDLKGEDSVPDTVHHVVVPVNPKTDRLWERLGKSHIRTDDVHAKD
NTRPGANSPEMWSEAIKILKGEYAVRAIKEHKMDQAIIFCRTKIDCDNLEQYFIQQGGGPDKKGHQFSCVCLHGDRKPHERKQNLERFKK
GDVRFLICTDVAARGIDIHGVPYVINVTLPDEKQNYVHRIGRVGRAERMGLAISLVATEKEKVWYHVCSSRGKGCYNTRLKEDGGCTIWY

--------------------------------------------------------------
>44034_44034_3_LAP3-DDX1_LAP3_chr4_17583437_ENST00000226299_DDX1_chr2_15746274_ENST00000233084_length(transcript)=2263nt_BP=547nt
GCGGGCGCACACGAATGCGGGCGCACACGAATGCGGGCGCACACGAATGCGGGCGCACCCTTGAGTCCCCTCCACAACCGCGGTTTGATC
CCAGCGGTCCAGTCGGCCGGTGCTGCCCATCCGTCCCGCCCCCTAGACGCACGTCCGCTCGCCCGGCGCCCGAGCCAGTCCGCGCGCACG
CCGTCTGCGCCCCGAAAGCCCCGCCCCAAGGCGCGCCCGCCCACCGCTCTCCACGTGCTCGCTGGAGGGCGGTGCGAGGGGCCGAGCCGA
CAAGATGTTCTTGCTGCCTCTTCCGGCTGCGGGGCGAGTAGTCGTCCGACGTCTGGCCGTGAGACGTTTCGGGAGCCGGAGTCTCTCCAC
CGCAGACATGACGAAGGGCCTTGTTTTAGGAATCTATTCCAAAGAAAAAGAAGATGATGTGCCACAGTTCACAAGTGCAGGAGAGAATTT
TGATAAATTGTTAGCTGGAAAGCTGAGAGAGACTTTGAACATATCTGGACCACCTCTGAAGGCAGGGAAGACTCGAACCTTTTATGGTCT
GCATCAGAATGCTGAACTGAAATTTAACTTCGGTGAAGAGGAATTTAAGTTTCCACCAAAAGATGGCTTTGTTGCTCTTTCCAAGGCACC
GGATGGTTACATTGTCAAATCACAGCACTCAGGTAATGCACAGGTGACACAAACAAAGTTTCTCCCCAATGCTCCGAAAGCTCTCATTGT
TGAACCTTCCCGGGAGTTAGCTGAACAAACTTTGAACAACATCAAGCAGTTTAAGAAATACATTGATAATCCTAAATTAAGGGAGCTTCT
GATAATTGGAGGTGTTGCAGCCCGGGATCAGCTCTCTGTTTTGGAAAATGGAGTAGATATAGTTGTAGGTACTCCGGGAAGACTAGATGA
CTTGGTGTCAACTGGAAAGCTGAACTTATCTCAAGTTAGATTCCTGGTCCTGGATGAAGCTGATGGGCTTCTTTCTCAAGGTTATTCTGA
TTTTATAAATAGGATGCACAATCAGATTCCTCAGGTTACCTCTGATGGAAAAAGACTTCAGGTGATTGTTTGCTCTGCCACTTTGCATTC
TTTCGATGTAAAGAAACTGTCCGAGAAGATAATGCATTTTCCTACATGGGTTGACTTAAAAGGAGAAGACTCTGTTCCAGATACTGTACA
CCATGTTGTTGTCCCAGTAAATCCCAAAACTGACAGACTCTGGGAAAGGCTTGGAAAGAGCCACATTAGAACTGATGATGTACATGCAAA
AGATAACACAAGACCTGGTGCTAATAGTCCAGAGATGTGGTCTGAAGCTATTAAAATCCTGAAAGGGGAGTATGCTGTCCGGGCAATCAA
GGAACATAAGATGGATCAAGCAATTATCTTCTGTAGAACCAAAATTGACTGTGATAACTTGGAGCAGTACTTTATACAACAAGGAGGAGG
ACCTGATAAAAAAGGACACCAGTTCTCATGTGTTTGTCTTCATGGTGACAGAAAGCCTCATGAGAGAAAGCAAAACTTGGAAAGATTTAA
GAAAGGAGATGTAAGATTCTTGATTTGCACAGATGTAGCTGCTAGAGGAATTGATATCCACGGTGTTCCTTATGTTATAAATGTCACTCT
GCCCGATGAAAAGCAAAACTACGTACATCGAATTGGCAGAGTAGGAAGAGCTGAAAGGATGGGTCTGGCAATTTCCCTGGTGGCAACAGA
AAAAGAAAAGGTTTGGTACCATGTATGTAGCAGCCGTGGAAAAGGGTGTTATAACACAAGACTCAAGGAAGATGGAGGCTGTACCATATG
GTACAACGAGATGCAGTTACTATCTGAGATAGAAGAACACCTGAACTGTACCATTTCTCAGGTTGAGCCGGATATAAAGGTACCAGTGGA
TGAATTTGATGGGAAAGTTACCTACGGTCAGAAAAGGGCTGCTGGTGGTGGAAGCTATAAAGGCCATGTGGATATTTTGGCACCTACTGT
TCAAGAGTTGGCTGCCCTTGAAAAGGAGGCGCAGACATCTTTCCTGCATCTTGGCTACCTTCCTAACCAGCTGTTCAGAACCTTCTGATT
TTTACATTTACTGAATAAGATTTGAGTAATGAAAGTCTGTAGTCTTAAAACTCTAAAACAGTTGTACTGCTTCCAAGCAGCAGTATTTAT
AGTAACGTAAGCTATTAATGCTAACTCTTGCATGTCAAGAAACATTAGTCTTAGGAATTCTTCAAAAAATGGCATCCCAATGAAAATAAA

>44034_44034_3_LAP3-DDX1_LAP3_chr4_17583437_ENST00000226299_DDX1_chr2_15746274_ENST00000233084_length(amino acids)=627AA_BP=121
MRPESPAPRRARPPLSTCSLEGGARGRADKMFLLPLPAAGRVVVRRLAVRRFGSRSLSTADMTKGLVLGIYSKEKEDDVPQFTSAGENFD
KLLAGKLRETLNISGPPLKAGKTRTFYGLHQNAELKFNFGEEEFKFPPKDGFVALSKAPDGYIVKSQHSGNAQVTQTKFLPNAPKALIVE
PSRELAEQTLNNIKQFKKYIDNPKLRELLIIGGVAARDQLSVLENGVDIVVGTPGRLDDLVSTGKLNLSQVRFLVLDEADGLLSQGYSDF
INRMHNQIPQVTSDGKRLQVIVCSATLHSFDVKKLSEKIMHFPTWVDLKGEDSVPDTVHHVVVPVNPKTDRLWERLGKSHIRTDDVHAKD
NTRPGANSPEMWSEAIKILKGEYAVRAIKEHKMDQAIIFCRTKIDCDNLEQYFIQQGGGPDKKGHQFSCVCLHGDRKPHERKQNLERFKK
GDVRFLICTDVAARGIDIHGVPYVINVTLPDEKQNYVHRIGRVGRAERMGLAISLVATEKEKVWYHVCSSRGKGCYNTRLKEDGGCTIWY

--------------------------------------------------------------
>44034_44034_4_LAP3-DDX1_LAP3_chr4_17583437_ENST00000226299_DDX1_chr2_15746274_ENST00000381341_length(transcript)=2273nt_BP=547nt
GCGGGCGCACACGAATGCGGGCGCACACGAATGCGGGCGCACACGAATGCGGGCGCACCCTTGAGTCCCCTCCACAACCGCGGTTTGATC
CCAGCGGTCCAGTCGGCCGGTGCTGCCCATCCGTCCCGCCCCCTAGACGCACGTCCGCTCGCCCGGCGCCCGAGCCAGTCCGCGCGCACG
CCGTCTGCGCCCCGAAAGCCCCGCCCCAAGGCGCGCCCGCCCACCGCTCTCCACGTGCTCGCTGGAGGGCGGTGCGAGGGGCCGAGCCGA
CAAGATGTTCTTGCTGCCTCTTCCGGCTGCGGGGCGAGTAGTCGTCCGACGTCTGGCCGTGAGACGTTTCGGGAGCCGGAGTCTCTCCAC
CGCAGACATGACGAAGGGCCTTGTTTTAGGAATCTATTCCAAAGAAAAAGAAGATGATGTGCCACAGTTCACAAGTGCAGGAGAGAATTT
TGATAAATTGTTAGCTGGAAAGCTGAGAGAGACTTTGAACATATCTGGACCACCTCTGAAGGCAGGGAAGACTCGAACCTTTTATGGTCT
GCATCAGAATGCTGAACTGAAATTTAACTTCGGTGAAGAGGAATTTAAGTTTCCACCAAAAGATGGCTTTGTTGCTCTTTCCAAGGCACC
GGATGGTTACATTGTCAAATCACAGCACTCAGGTAATGCACAGGTGACACAAACAAAGTTTCTCCCCAATGCTCCGAAAGCTCTCATTGT
TGAACCTTCCCGGGAGTTAGCTGAACAAACTTTGAACAACATCAAGCAGTTTAAGAAATACATTGATAATCCTAAATTAAGGGAGCTTCT
GATAATTGGAGGTGTTGCAGCCCGGGATCAGCTCTCTGTTTTGGAAAATGGAGTAGATATAGTTGTAGGTACTCCGGGAAGACTAGATGA
CTTGGTGTCAACTGGAAAGCTGAACTTATCTCAAGTTAGATTCCTGGTCCTGGATGAAGCTGATGGGCTTCTTTCTCAAGGTTATTCTGA
TTTTATAAATAGGATGCACAATCAGATTCCTCAGGTTACCTCTGATGGAAAAAGACTTCAGGTGATTGTTTGCTCTGCCACTTTGCATTC
TTTCGATGTAAAGAAACTGTCCGAGAAGATAATGCATTTTCCTACATGGGTTGACTTAAAAGGAGAAGACTCTGTTCCAGATACTGTACA
CCATGTTGTTGTCCCAGTAAATCCCAAAACTGACAGACTCTGGGAAAGGCTTGGAAAGAGCCACATTAGAACTGATGATGTACATGCAAA
AGATAACACAAGACCTGGTGCTAATAGTCCAGAGATGTGGTCTGAAGCTATTAAAATCCTGAAAGGGGAGTATGCTGTCCGGGCAATCAA
GGAACATAAGATGGATCAAGCAATTATCTTCTGTAGAACCAAAATTGACTGTGATAACTTGGAGCAGTACTTTATACAACAAGGAGGAGG
ACCTGATAAAAAAGGACACCAGTTCTCATGTGTTTGTCTTCATGGTGACAGAAAGCCTCATGAGAGAAAGCAAAACTTGGAAAGATTTAA
GAAAGGAGATGTAAGATTCTTGATTTGCACAGATGTAGCTGCTAGAGGAATTGATATCCACGGTGTTCCTTATGTTATAAATGTCACTCT
GCCCGATGAAAAGCAAAACTACGTACATCGAATTGGCAGAGTAGGAAGAGCTGAAAGGATGGGTCTGGCAATTTCCCTGGTGGCAACAGA
AAAAGAAAAGGTTTGGTACCATGTATGTAGCAGCCGTGGAAAAGGGTGTTATAACACAAGACTCAAGGAAGATGGAGGCTGTACCATATG
GTACAACGAGATGCAGTTACTATCTGAGATAGAAGAACACCTGAACTGTACCATTTCTCAGGTTGAGCCGGATATAAAGGTACCAGTGGA
TGAATTTGATGGGAAAGTTACCTACGGTCAGAAAAGGGCTGCTGGTGGTGGAAGCTATAAAGGCCATGTGGATATTTTGGCACCTACTGT
TCAAGAGTTGGCTGCCCTTGAAAAGGAGGCGCAGACATCTTTCCTGCATCTTGGCTACCTTCCTAACCAGCTGTTCAGAACCTTCTGATT
TTTACATTTACTGAATAAGATTTGAGTAATGAAAGTCTGTAGTCTTAAAACTCTAAAACAGTTGTACTGCTTCCAAGCAGCAGTATTTAT
AGTAACGTAAGCTATTAATGCTAACTCTTGCATGTCAAGAAACATTAGTCTTAGGAATTCTTCAAAAAATGGCATCCCAATGAAAATAAA

>44034_44034_4_LAP3-DDX1_LAP3_chr4_17583437_ENST00000226299_DDX1_chr2_15746274_ENST00000381341_length(amino acids)=627AA_BP=121
MRPESPAPRRARPPLSTCSLEGGARGRADKMFLLPLPAAGRVVVRRLAVRRFGSRSLSTADMTKGLVLGIYSKEKEDDVPQFTSAGENFD
KLLAGKLRETLNISGPPLKAGKTRTFYGLHQNAELKFNFGEEEFKFPPKDGFVALSKAPDGYIVKSQHSGNAQVTQTKFLPNAPKALIVE
PSRELAEQTLNNIKQFKKYIDNPKLRELLIIGGVAARDQLSVLENGVDIVVGTPGRLDDLVSTGKLNLSQVRFLVLDEADGLLSQGYSDF
INRMHNQIPQVTSDGKRLQVIVCSATLHSFDVKKLSEKIMHFPTWVDLKGEDSVPDTVHHVVVPVNPKTDRLWERLGKSHIRTDDVHAKD
NTRPGANSPEMWSEAIKILKGEYAVRAIKEHKMDQAIIFCRTKIDCDNLEQYFIQQGGGPDKKGHQFSCVCLHGDRKPHERKQNLERFKK
GDVRFLICTDVAARGIDIHGVPYVINVTLPDEKQNYVHRIGRVGRAERMGLAISLVATEKEKVWYHVCSSRGKGCYNTRLKEDGGCTIWY

--------------------------------------------------------------
>44034_44034_5_LAP3-DDX1_LAP3_chr4_17583437_ENST00000606142_DDX1_chr2_15746273_ENST00000233084_length(transcript)=1960nt_BP=244nt
GCGAGTAGTCGTCCGACGTCTGGCCGTGAGACGTTTCGGGAGCCGGAGTCTCTCCACCGCAGACATGACGAAGGGCCTTGTTTTAGGAAT
CTATTCCAAAGAAAAAGAAGATGATGTGCCACAGTTCACAAGTGCAGGAGAGAATTTTGATAAATTGTTAGCTGGAAAGCTGAGAGAGAC
TTTGAACATATCTGGACCACCTCTGAAGGCAGGGAAGACTCGAACCTTTTATGGTCTGCATCAGAATGCTGAACTGAAATTTAACTTCGG
TGAAGAGGAATTTAAGTTTCCACCAAAAGATGGCTTTGTTGCTCTTTCCAAGGCACCGGATGGTTACATTGTCAAATCACAGCACTCAGG
TAATGCACAGGTGACACAAACAAAGTTTCTCCCCAATGCTCCGAAAGCTCTCATTGTTGAACCTTCCCGGGAGTTAGCTGAACAAACTTT
GAACAACATCAAGCAGTTTAAGAAATACATTGATAATCCTAAATTAAGGGAGCTTCTGATAATTGGAGGTGTTGCAGCCCGGGATCAGCT
CTCTGTTTTGGAAAATGGAGTAGATATAGTTGTAGGTACTCCGGGAAGACTAGATGACTTGGTGTCAACTGGAAAGCTGAACTTATCTCA
AGTTAGATTCCTGGTCCTGGATGAAGCTGATGGGCTTCTTTCTCAAGGTTATTCTGATTTTATAAATAGGATGCACAATCAGATTCCTCA
GGTTACCTCTGATGGAAAAAGACTTCAGGTGATTGTTTGCTCTGCCACTTTGCATTCTTTCGATGTAAAGAAACTGTCCGAGAAGATAAT
GCATTTTCCTACATGGGTTGACTTAAAAGGAGAAGACTCTGTTCCAGATACTGTACACCATGTTGTTGTCCCAGTAAATCCCAAAACTGA
CAGACTCTGGGAAAGGCTTGGAAAGAGCCACATTAGAACTGATGATGTACATGCAAAAGATAACACAAGACCTGGTGCTAATAGTCCAGA
GATGTGGTCTGAAGCTATTAAAATCCTGAAAGGGGAGTATGCTGTCCGGGCAATCAAGGAACATAAGATGGATCAAGCAATTATCTTCTG
TAGAACCAAAATTGACTGTGATAACTTGGAGCAGTACTTTATACAACAAGGAGGAGGACCTGATAAAAAAGGACACCAGTTCTCATGTGT
TTGTCTTCATGGTGACAGAAAGCCTCATGAGAGAAAGCAAAACTTGGAAAGATTTAAGAAAGGAGATGTAAGATTCTTGATTTGCACAGA
TGTAGCTGCTAGAGGAATTGATATCCACGGTGTTCCTTATGTTATAAATGTCACTCTGCCCGATGAAAAGCAAAACTACGTACATCGAAT
TGGCAGAGTAGGAAGAGCTGAAAGGATGGGTCTGGCAATTTCCCTGGTGGCAACAGAAAAAGAAAAGGTTTGGTACCATGTATGTAGCAG
CCGTGGAAAAGGGTGTTATAACACAAGACTCAAGGAAGATGGAGGCTGTACCATATGGTACAACGAGATGCAGTTACTATCTGAGATAGA
AGAACACCTGAACTGTACCATTTCTCAGGTTGAGCCGGATATAAAGGTACCAGTGGATGAATTTGATGGGAAAGTTACCTACGGTCAGAA
AAGGGCTGCTGGTGGTGGAAGCTATAAAGGCCATGTGGATATTTTGGCACCTACTGTTCAAGAGTTGGCTGCCCTTGAAAAGGAGGCGCA
GACATCTTTCCTGCATCTTGGCTACCTTCCTAACCAGCTGTTCAGAACCTTCTGATTTTTACATTTACTGAATAAGATTTGAGTAATGAA
AGTCTGTAGTCTTAAAACTCTAAAACAGTTGTACTGCTTCCAAGCAGCAGTATTTATAGTAACGTAAGCTATTAATGCTAACTCTTGCAT

>44034_44034_5_LAP3-DDX1_LAP3_chr4_17583437_ENST00000606142_DDX1_chr2_15746273_ENST00000233084_length(amino acids)=581AA_BP=75
MAVRRFGSRSLSTADMTKGLVLGIYSKEKEDDVPQFTSAGENFDKLLAGKLRETLNISGPPLKAGKTRTFYGLHQNAELKFNFGEEEFKF
PPKDGFVALSKAPDGYIVKSQHSGNAQVTQTKFLPNAPKALIVEPSRELAEQTLNNIKQFKKYIDNPKLRELLIIGGVAARDQLSVLENG
VDIVVGTPGRLDDLVSTGKLNLSQVRFLVLDEADGLLSQGYSDFINRMHNQIPQVTSDGKRLQVIVCSATLHSFDVKKLSEKIMHFPTWV
DLKGEDSVPDTVHHVVVPVNPKTDRLWERLGKSHIRTDDVHAKDNTRPGANSPEMWSEAIKILKGEYAVRAIKEHKMDQAIIFCRTKIDC
DNLEQYFIQQGGGPDKKGHQFSCVCLHGDRKPHERKQNLERFKKGDVRFLICTDVAARGIDIHGVPYVINVTLPDEKQNYVHRIGRVGRA
ERMGLAISLVATEKEKVWYHVCSSRGKGCYNTRLKEDGGCTIWYNEMQLLSEIEEHLNCTISQVEPDIKVPVDEFDGKVTYGQKRAAGGG

--------------------------------------------------------------
>44034_44034_6_LAP3-DDX1_LAP3_chr4_17583437_ENST00000606142_DDX1_chr2_15746273_ENST00000381341_length(transcript)=1970nt_BP=244nt
GCGAGTAGTCGTCCGACGTCTGGCCGTGAGACGTTTCGGGAGCCGGAGTCTCTCCACCGCAGACATGACGAAGGGCCTTGTTTTAGGAAT
CTATTCCAAAGAAAAAGAAGATGATGTGCCACAGTTCACAAGTGCAGGAGAGAATTTTGATAAATTGTTAGCTGGAAAGCTGAGAGAGAC
TTTGAACATATCTGGACCACCTCTGAAGGCAGGGAAGACTCGAACCTTTTATGGTCTGCATCAGAATGCTGAACTGAAATTTAACTTCGG
TGAAGAGGAATTTAAGTTTCCACCAAAAGATGGCTTTGTTGCTCTTTCCAAGGCACCGGATGGTTACATTGTCAAATCACAGCACTCAGG
TAATGCACAGGTGACACAAACAAAGTTTCTCCCCAATGCTCCGAAAGCTCTCATTGTTGAACCTTCCCGGGAGTTAGCTGAACAAACTTT
GAACAACATCAAGCAGTTTAAGAAATACATTGATAATCCTAAATTAAGGGAGCTTCTGATAATTGGAGGTGTTGCAGCCCGGGATCAGCT
CTCTGTTTTGGAAAATGGAGTAGATATAGTTGTAGGTACTCCGGGAAGACTAGATGACTTGGTGTCAACTGGAAAGCTGAACTTATCTCA
AGTTAGATTCCTGGTCCTGGATGAAGCTGATGGGCTTCTTTCTCAAGGTTATTCTGATTTTATAAATAGGATGCACAATCAGATTCCTCA
GGTTACCTCTGATGGAAAAAGACTTCAGGTGATTGTTTGCTCTGCCACTTTGCATTCTTTCGATGTAAAGAAACTGTCCGAGAAGATAAT
GCATTTTCCTACATGGGTTGACTTAAAAGGAGAAGACTCTGTTCCAGATACTGTACACCATGTTGTTGTCCCAGTAAATCCCAAAACTGA
CAGACTCTGGGAAAGGCTTGGAAAGAGCCACATTAGAACTGATGATGTACATGCAAAAGATAACACAAGACCTGGTGCTAATAGTCCAGA
GATGTGGTCTGAAGCTATTAAAATCCTGAAAGGGGAGTATGCTGTCCGGGCAATCAAGGAACATAAGATGGATCAAGCAATTATCTTCTG
TAGAACCAAAATTGACTGTGATAACTTGGAGCAGTACTTTATACAACAAGGAGGAGGACCTGATAAAAAAGGACACCAGTTCTCATGTGT
TTGTCTTCATGGTGACAGAAAGCCTCATGAGAGAAAGCAAAACTTGGAAAGATTTAAGAAAGGAGATGTAAGATTCTTGATTTGCACAGA
TGTAGCTGCTAGAGGAATTGATATCCACGGTGTTCCTTATGTTATAAATGTCACTCTGCCCGATGAAAAGCAAAACTACGTACATCGAAT
TGGCAGAGTAGGAAGAGCTGAAAGGATGGGTCTGGCAATTTCCCTGGTGGCAACAGAAAAAGAAAAGGTTTGGTACCATGTATGTAGCAG
CCGTGGAAAAGGGTGTTATAACACAAGACTCAAGGAAGATGGAGGCTGTACCATATGGTACAACGAGATGCAGTTACTATCTGAGATAGA
AGAACACCTGAACTGTACCATTTCTCAGGTTGAGCCGGATATAAAGGTACCAGTGGATGAATTTGATGGGAAAGTTACCTACGGTCAGAA
AAGGGCTGCTGGTGGTGGAAGCTATAAAGGCCATGTGGATATTTTGGCACCTACTGTTCAAGAGTTGGCTGCCCTTGAAAAGGAGGCGCA
GACATCTTTCCTGCATCTTGGCTACCTTCCTAACCAGCTGTTCAGAACCTTCTGATTTTTACATTTACTGAATAAGATTTGAGTAATGAA
AGTCTGTAGTCTTAAAACTCTAAAACAGTTGTACTGCTTCCAAGCAGCAGTATTTATAGTAACGTAAGCTATTAATGCTAACTCTTGCAT

>44034_44034_6_LAP3-DDX1_LAP3_chr4_17583437_ENST00000606142_DDX1_chr2_15746273_ENST00000381341_length(amino acids)=581AA_BP=75
MAVRRFGSRSLSTADMTKGLVLGIYSKEKEDDVPQFTSAGENFDKLLAGKLRETLNISGPPLKAGKTRTFYGLHQNAELKFNFGEEEFKF
PPKDGFVALSKAPDGYIVKSQHSGNAQVTQTKFLPNAPKALIVEPSRELAEQTLNNIKQFKKYIDNPKLRELLIIGGVAARDQLSVLENG
VDIVVGTPGRLDDLVSTGKLNLSQVRFLVLDEADGLLSQGYSDFINRMHNQIPQVTSDGKRLQVIVCSATLHSFDVKKLSEKIMHFPTWV
DLKGEDSVPDTVHHVVVPVNPKTDRLWERLGKSHIRTDDVHAKDNTRPGANSPEMWSEAIKILKGEYAVRAIKEHKMDQAIIFCRTKIDC
DNLEQYFIQQGGGPDKKGHQFSCVCLHGDRKPHERKQNLERFKKGDVRFLICTDVAARGIDIHGVPYVINVTLPDEKQNYVHRIGRVGRA
ERMGLAISLVATEKEKVWYHVCSSRGKGCYNTRLKEDGGCTIWYNEMQLLSEIEEHLNCTISQVEPDIKVPVDEFDGKVTYGQKRAAGGG

--------------------------------------------------------------
>44034_44034_7_LAP3-DDX1_LAP3_chr4_17583437_ENST00000606142_DDX1_chr2_15746274_ENST00000233084_length(transcript)=1960nt_BP=244nt
GCGAGTAGTCGTCCGACGTCTGGCCGTGAGACGTTTCGGGAGCCGGAGTCTCTCCACCGCAGACATGACGAAGGGCCTTGTTTTAGGAAT
CTATTCCAAAGAAAAAGAAGATGATGTGCCACAGTTCACAAGTGCAGGAGAGAATTTTGATAAATTGTTAGCTGGAAAGCTGAGAGAGAC
TTTGAACATATCTGGACCACCTCTGAAGGCAGGGAAGACTCGAACCTTTTATGGTCTGCATCAGAATGCTGAACTGAAATTTAACTTCGG
TGAAGAGGAATTTAAGTTTCCACCAAAAGATGGCTTTGTTGCTCTTTCCAAGGCACCGGATGGTTACATTGTCAAATCACAGCACTCAGG
TAATGCACAGGTGACACAAACAAAGTTTCTCCCCAATGCTCCGAAAGCTCTCATTGTTGAACCTTCCCGGGAGTTAGCTGAACAAACTTT
GAACAACATCAAGCAGTTTAAGAAATACATTGATAATCCTAAATTAAGGGAGCTTCTGATAATTGGAGGTGTTGCAGCCCGGGATCAGCT
CTCTGTTTTGGAAAATGGAGTAGATATAGTTGTAGGTACTCCGGGAAGACTAGATGACTTGGTGTCAACTGGAAAGCTGAACTTATCTCA
AGTTAGATTCCTGGTCCTGGATGAAGCTGATGGGCTTCTTTCTCAAGGTTATTCTGATTTTATAAATAGGATGCACAATCAGATTCCTCA
GGTTACCTCTGATGGAAAAAGACTTCAGGTGATTGTTTGCTCTGCCACTTTGCATTCTTTCGATGTAAAGAAACTGTCCGAGAAGATAAT
GCATTTTCCTACATGGGTTGACTTAAAAGGAGAAGACTCTGTTCCAGATACTGTACACCATGTTGTTGTCCCAGTAAATCCCAAAACTGA
CAGACTCTGGGAAAGGCTTGGAAAGAGCCACATTAGAACTGATGATGTACATGCAAAAGATAACACAAGACCTGGTGCTAATAGTCCAGA
GATGTGGTCTGAAGCTATTAAAATCCTGAAAGGGGAGTATGCTGTCCGGGCAATCAAGGAACATAAGATGGATCAAGCAATTATCTTCTG
TAGAACCAAAATTGACTGTGATAACTTGGAGCAGTACTTTATACAACAAGGAGGAGGACCTGATAAAAAAGGACACCAGTTCTCATGTGT
TTGTCTTCATGGTGACAGAAAGCCTCATGAGAGAAAGCAAAACTTGGAAAGATTTAAGAAAGGAGATGTAAGATTCTTGATTTGCACAGA
TGTAGCTGCTAGAGGAATTGATATCCACGGTGTTCCTTATGTTATAAATGTCACTCTGCCCGATGAAAAGCAAAACTACGTACATCGAAT
TGGCAGAGTAGGAAGAGCTGAAAGGATGGGTCTGGCAATTTCCCTGGTGGCAACAGAAAAAGAAAAGGTTTGGTACCATGTATGTAGCAG
CCGTGGAAAAGGGTGTTATAACACAAGACTCAAGGAAGATGGAGGCTGTACCATATGGTACAACGAGATGCAGTTACTATCTGAGATAGA
AGAACACCTGAACTGTACCATTTCTCAGGTTGAGCCGGATATAAAGGTACCAGTGGATGAATTTGATGGGAAAGTTACCTACGGTCAGAA
AAGGGCTGCTGGTGGTGGAAGCTATAAAGGCCATGTGGATATTTTGGCACCTACTGTTCAAGAGTTGGCTGCCCTTGAAAAGGAGGCGCA
GACATCTTTCCTGCATCTTGGCTACCTTCCTAACCAGCTGTTCAGAACCTTCTGATTTTTACATTTACTGAATAAGATTTGAGTAATGAA
AGTCTGTAGTCTTAAAACTCTAAAACAGTTGTACTGCTTCCAAGCAGCAGTATTTATAGTAACGTAAGCTATTAATGCTAACTCTTGCAT

>44034_44034_7_LAP3-DDX1_LAP3_chr4_17583437_ENST00000606142_DDX1_chr2_15746274_ENST00000233084_length(amino acids)=581AA_BP=75
MAVRRFGSRSLSTADMTKGLVLGIYSKEKEDDVPQFTSAGENFDKLLAGKLRETLNISGPPLKAGKTRTFYGLHQNAELKFNFGEEEFKF
PPKDGFVALSKAPDGYIVKSQHSGNAQVTQTKFLPNAPKALIVEPSRELAEQTLNNIKQFKKYIDNPKLRELLIIGGVAARDQLSVLENG
VDIVVGTPGRLDDLVSTGKLNLSQVRFLVLDEADGLLSQGYSDFINRMHNQIPQVTSDGKRLQVIVCSATLHSFDVKKLSEKIMHFPTWV
DLKGEDSVPDTVHHVVVPVNPKTDRLWERLGKSHIRTDDVHAKDNTRPGANSPEMWSEAIKILKGEYAVRAIKEHKMDQAIIFCRTKIDC
DNLEQYFIQQGGGPDKKGHQFSCVCLHGDRKPHERKQNLERFKKGDVRFLICTDVAARGIDIHGVPYVINVTLPDEKQNYVHRIGRVGRA
ERMGLAISLVATEKEKVWYHVCSSRGKGCYNTRLKEDGGCTIWYNEMQLLSEIEEHLNCTISQVEPDIKVPVDEFDGKVTYGQKRAAGGG

--------------------------------------------------------------
>44034_44034_8_LAP3-DDX1_LAP3_chr4_17583437_ENST00000606142_DDX1_chr2_15746274_ENST00000381341_length(transcript)=1970nt_BP=244nt
GCGAGTAGTCGTCCGACGTCTGGCCGTGAGACGTTTCGGGAGCCGGAGTCTCTCCACCGCAGACATGACGAAGGGCCTTGTTTTAGGAAT
CTATTCCAAAGAAAAAGAAGATGATGTGCCACAGTTCACAAGTGCAGGAGAGAATTTTGATAAATTGTTAGCTGGAAAGCTGAGAGAGAC
TTTGAACATATCTGGACCACCTCTGAAGGCAGGGAAGACTCGAACCTTTTATGGTCTGCATCAGAATGCTGAACTGAAATTTAACTTCGG
TGAAGAGGAATTTAAGTTTCCACCAAAAGATGGCTTTGTTGCTCTTTCCAAGGCACCGGATGGTTACATTGTCAAATCACAGCACTCAGG
TAATGCACAGGTGACACAAACAAAGTTTCTCCCCAATGCTCCGAAAGCTCTCATTGTTGAACCTTCCCGGGAGTTAGCTGAACAAACTTT
GAACAACATCAAGCAGTTTAAGAAATACATTGATAATCCTAAATTAAGGGAGCTTCTGATAATTGGAGGTGTTGCAGCCCGGGATCAGCT
CTCTGTTTTGGAAAATGGAGTAGATATAGTTGTAGGTACTCCGGGAAGACTAGATGACTTGGTGTCAACTGGAAAGCTGAACTTATCTCA
AGTTAGATTCCTGGTCCTGGATGAAGCTGATGGGCTTCTTTCTCAAGGTTATTCTGATTTTATAAATAGGATGCACAATCAGATTCCTCA
GGTTACCTCTGATGGAAAAAGACTTCAGGTGATTGTTTGCTCTGCCACTTTGCATTCTTTCGATGTAAAGAAACTGTCCGAGAAGATAAT
GCATTTTCCTACATGGGTTGACTTAAAAGGAGAAGACTCTGTTCCAGATACTGTACACCATGTTGTTGTCCCAGTAAATCCCAAAACTGA
CAGACTCTGGGAAAGGCTTGGAAAGAGCCACATTAGAACTGATGATGTACATGCAAAAGATAACACAAGACCTGGTGCTAATAGTCCAGA
GATGTGGTCTGAAGCTATTAAAATCCTGAAAGGGGAGTATGCTGTCCGGGCAATCAAGGAACATAAGATGGATCAAGCAATTATCTTCTG
TAGAACCAAAATTGACTGTGATAACTTGGAGCAGTACTTTATACAACAAGGAGGAGGACCTGATAAAAAAGGACACCAGTTCTCATGTGT
TTGTCTTCATGGTGACAGAAAGCCTCATGAGAGAAAGCAAAACTTGGAAAGATTTAAGAAAGGAGATGTAAGATTCTTGATTTGCACAGA
TGTAGCTGCTAGAGGAATTGATATCCACGGTGTTCCTTATGTTATAAATGTCACTCTGCCCGATGAAAAGCAAAACTACGTACATCGAAT
TGGCAGAGTAGGAAGAGCTGAAAGGATGGGTCTGGCAATTTCCCTGGTGGCAACAGAAAAAGAAAAGGTTTGGTACCATGTATGTAGCAG
CCGTGGAAAAGGGTGTTATAACACAAGACTCAAGGAAGATGGAGGCTGTACCATATGGTACAACGAGATGCAGTTACTATCTGAGATAGA
AGAACACCTGAACTGTACCATTTCTCAGGTTGAGCCGGATATAAAGGTACCAGTGGATGAATTTGATGGGAAAGTTACCTACGGTCAGAA
AAGGGCTGCTGGTGGTGGAAGCTATAAAGGCCATGTGGATATTTTGGCACCTACTGTTCAAGAGTTGGCTGCCCTTGAAAAGGAGGCGCA
GACATCTTTCCTGCATCTTGGCTACCTTCCTAACCAGCTGTTCAGAACCTTCTGATTTTTACATTTACTGAATAAGATTTGAGTAATGAA
AGTCTGTAGTCTTAAAACTCTAAAACAGTTGTACTGCTTCCAAGCAGCAGTATTTATAGTAACGTAAGCTATTAATGCTAACTCTTGCAT

>44034_44034_8_LAP3-DDX1_LAP3_chr4_17583437_ENST00000606142_DDX1_chr2_15746274_ENST00000381341_length(amino acids)=581AA_BP=75
MAVRRFGSRSLSTADMTKGLVLGIYSKEKEDDVPQFTSAGENFDKLLAGKLRETLNISGPPLKAGKTRTFYGLHQNAELKFNFGEEEFKF
PPKDGFVALSKAPDGYIVKSQHSGNAQVTQTKFLPNAPKALIVEPSRELAEQTLNNIKQFKKYIDNPKLRELLIIGGVAARDQLSVLENG
VDIVVGTPGRLDDLVSTGKLNLSQVRFLVLDEADGLLSQGYSDFINRMHNQIPQVTSDGKRLQVIVCSATLHSFDVKKLSEKIMHFPTWV
DLKGEDSVPDTVHHVVVPVNPKTDRLWERLGKSHIRTDDVHAKDNTRPGANSPEMWSEAIKILKGEYAVRAIKEHKMDQAIIFCRTKIDC
DNLEQYFIQQGGGPDKKGHQFSCVCLHGDRKPHERKQNLERFKKGDVRFLICTDVAARGIDIHGVPYVINVTLPDEKQNYVHRIGRVGRA
ERMGLAISLVATEKEKVWYHVCSSRGKGCYNTRLKEDGGCTIWYNEMQLLSEIEEHLNCTISQVEPDIKVPVDEFDGKVTYGQKRAAGGG

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for LAP3-DDX1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Tgene	DDX1	chr4:17583437	chr2:15746273	ENST00000233084		10	26	1_448	234.0	741.0	dsRNA
Tgene	DDX1	chr4:17583437	chr2:15746273	ENST00000381341		11	27	1_448	234.0	741.0	dsRNA
Tgene	DDX1	chr4:17583437	chr2:15746274	ENST00000233084		10	26	1_448	234.0	741.0	dsRNA
Tgene	DDX1	chr4:17583437	chr2:15746274	ENST00000381341		11	27	1_448	234.0	741.0	dsRNA

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for LAP3-DDX1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for LAP3-DDX1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source