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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
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Fusion gene:LAPTM4A-PUM2 (FusionGDB2 ID:44049)

Fusion Gene Summary for LAPTM4A-PUM2

Fusion gene summary

Fusion gene information	Fusion gene name: LAPTM4A-PUM2
	Fusion gene ID: 44049
		Hgene	Tgene
	Gene symbol	LAPTM4A	PUM2
	Gene ID	9741	23369
	Gene name	lysosomal protein transmembrane 4 alpha	pumilio RNA binding family member 2
	Synonyms	HUMORF13\|LAPTM4\|MBNT\|Mtrp	PUMH2\|PUML2
	Cytomap	2p24.1	2p24.1
	Type of gene	protein-coding	protein-coding
	Description	lysosomal-associated transmembrane protein 4Agolgi 4-transmembrane-spanning transporter MTPlysosomal-associated protein transmembrane 4 alphamembrane nucleoside transporter	pumilio homolog 2pumilio-2
	Modification date	20200313	20200313
	UniProtAcc	Q15012	.
	Ensembl transtripts involved in fusion gene	ENST00000175091,	ENST00000403432, ENST00000420234, ENST00000536417, ENST00000319801, ENST00000338086, ENST00000361078,
Fusion gene scores	* DoF score	12 X 11 X 4=528	11 X 9 X 5=495
	# samples	12	13
	** MAII score	log2(12/528*10)=-2.13750352374993 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(13/495*10)=-1.92891690193852 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: LAPTM4A [Title/Abstract] AND PUM2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	LAPTM4A(20251171)-PUM2(20527139), # samples:2
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	PUM2	GO:0010608	posttranscriptional regulation of gene expression	25100735
Tgene	PUM2	GO:0043488	regulation of mRNA stability	26724866
Tgene	PUM2	GO:0051983	regulation of chromosome segregation	26724866
Tgene	PUM2	GO:1900246	positive regulation of RIG-I signaling pathway	25340845

Fusion gene breakpoints across LAPTM4A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across PUM2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-FP-8631-01A	LAPTM4A	chr2	20251171	-	PUM2	chr2	20527139	-

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Fusion Gene ORF analysis for LAPTM4A-PUM2

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000175091	ENST00000403432	LAPTM4A	chr2	20251171	-	PUM2	chr2	20527139	-
5CDS-5UTR	ENST00000175091	ENST00000420234	LAPTM4A	chr2	20251171	-	PUM2	chr2	20527139	-
5CDS-5UTR	ENST00000175091	ENST00000536417	LAPTM4A	chr2	20251171	-	PUM2	chr2	20527139	-
In-frame	ENST00000175091	ENST00000319801	LAPTM4A	chr2	20251171	-	PUM2	chr2	20527139	-
In-frame	ENST00000175091	ENST00000338086	LAPTM4A	chr2	20251171	-	PUM2	chr2	20527139	-
In-frame	ENST00000175091	ENST00000361078	LAPTM4A	chr2	20251171	-	PUM2	chr2	20527139	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000175091	LAPTM4A	chr2	20251171	-	ENST00000338086	PUM2	chr2	20527139	-	6731	619	642	3836	1064
ENST00000175091	LAPTM4A	chr2	20251171	-	ENST00000319801	PUM2	chr2	20527139	-	6499	619	642	3605	987
ENST00000175091	LAPTM4A	chr2	20251171	-	ENST00000361078	PUM2	chr2	20527139	-	6736	619	642	3842	1066

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000175091	ENST00000338086	LAPTM4A	chr2	20251171	-	PUM2	chr2	20527139	-	0.000266485	0.9997335
ENST00000175091	ENST00000319801	LAPTM4A	chr2	20251171	-	PUM2	chr2	20527139	-	0.000188928	0.9998111
ENST00000175091	ENST00000361078	LAPTM4A	chr2	20251171	-	PUM2	chr2	20527139	-	0.000223212	0.9997768

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Fusion Genomic Features for LAPTM4A-PUM2

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for LAPTM4A-PUM2

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:20251171/chr2:20527139)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
LAPTM4A Q15012	.
FUNCTION: May function in the transport of nucleosides and/or nucleoside derivatives between the cytosol and the lumen of an intracellular membrane-bound compartment. {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000319801

-1

278_488

988.0

Compositional bias

Note=Ala-rich

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000319801

-1

359_405

988.0

Compositional bias

Note=Gln-rich

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000319801

-1

520_687

988.0

Compositional bias

Note=Ser-rich

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000338086

-1

278_488

1065.0

Compositional bias

Note=Ala-rich

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000338086

-1

359_405

1065.0

Compositional bias

Note=Gln-rich

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000338086

-1

520_687

1065.0

Compositional bias

Note=Ser-rich

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000361078

-1

278_488

1067.0

Compositional bias

Note=Ala-rich

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000361078

-1

359_405

1067.0

Compositional bias

Note=Gln-rich

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000361078

-1

520_687

1067.0

Compositional bias

Note=Ser-rich

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000403432

278_488

1065.0

Compositional bias

Note=Ala-rich

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000403432

359_405

1065.0

Compositional bias

Note=Gln-rich

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000403432

520_687

1065.0

Compositional bias

Note=Ser-rich

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000319801

-1

706_1048

988.0

Domain

PUM-HD

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000338086

-1

706_1048

1065.0

Domain

PUM-HD

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000361078

-1

706_1048

1067.0

Domain

PUM-HD

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000403432

706_1048

1065.0

Domain

PUM-HD

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000319801

-1

1002_1006

988.0

Region

Uracil-nucleotide binding in RNA target

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000319801

-1

741_745

988.0

Region

Adenine-nucleotide binding in RNA target

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000319801

-1

777_781

988.0

Region

Uracil-nucleotide binding in RNA target

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000319801

-1

813_817

988.0

Region

Adenine-nucleotide binding in RNA target

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000319801

-1

851_855

988.0

Region

Non-specific-nucleotide binding in RNA target

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000319801

-1

887_891

988.0

Region

Adenine-nucleotide binding in RNA target

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000319801

-1

923_927

988.0

Region

Uracil-nucleotide binding in RNA target

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000319801

-1

959_963

988.0

Region

Guanine-nucleotide binding in RNA target

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000338086

-1

1002_1006

1065.0

Region

Uracil-nucleotide binding in RNA target

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000338086

-1

741_745

1065.0

Region

Adenine-nucleotide binding in RNA target

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000338086

-1

777_781

1065.0

Region

Uracil-nucleotide binding in RNA target

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000338086

-1

813_817

1065.0

Region

Adenine-nucleotide binding in RNA target

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000338086

-1

851_855

1065.0

Region

Non-specific-nucleotide binding in RNA target

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000338086

-1

887_891

1065.0

Region

Adenine-nucleotide binding in RNA target

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000338086

-1

923_927

1065.0

Region

Uracil-nucleotide binding in RNA target

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000338086

-1

959_963

1065.0

Region

Guanine-nucleotide binding in RNA target

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000361078

-1

1002_1006

1067.0

Region

Uracil-nucleotide binding in RNA target

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000361078

-1

741_745

1067.0

Region

Adenine-nucleotide binding in RNA target

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000361078

-1

777_781

1067.0

Region

Uracil-nucleotide binding in RNA target

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000361078

-1

813_817

1067.0

Region

Adenine-nucleotide binding in RNA target

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000361078

-1

851_855

1067.0

Region

Non-specific-nucleotide binding in RNA target

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000361078

-1

887_891

1067.0

Region

Adenine-nucleotide binding in RNA target

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000361078

-1

923_927

1067.0

Region

Uracil-nucleotide binding in RNA target

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000361078

-1

959_963

1067.0

Region

Guanine-nucleotide binding in RNA target

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000403432

1002_1006

1065.0

Region

Uracil-nucleotide binding in RNA target

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000403432

741_745

1065.0

Region

Adenine-nucleotide binding in RNA target

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000403432

777_781

1065.0

Region

Uracil-nucleotide binding in RNA target

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000403432

813_817

1065.0

Region

Adenine-nucleotide binding in RNA target

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000403432

851_855

1065.0

Region

Non-specific-nucleotide binding in RNA target

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000403432

887_891

1065.0

Region

Adenine-nucleotide binding in RNA target

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000403432

923_927

1065.0

Region

Uracil-nucleotide binding in RNA target

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000403432

959_963

1065.0

Region

Guanine-nucleotide binding in RNA target

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000319801

-1

726_761

988.0

Repeat

Pumilio 1

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000319801

-1

762_797

988.0

Repeat

Pumilio 2

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000319801

-1

798_835

988.0

Repeat

Pumilio 3

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000319801

-1

836_871

988.0

Repeat

Pumilio 4

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000319801

-1

872_907

988.0

Repeat

Pumilio 5

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000319801

-1

908_943

988.0

Repeat

Pumilio 6

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000319801

-1

944_979

988.0

Repeat

Pumilio 7

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000319801

-1

983_1022

988.0

Repeat

Pumilio 8

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000338086

-1

726_761

1065.0

Repeat

Pumilio 1

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000338086

-1

762_797

1065.0

Repeat

Pumilio 2

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000338086

-1

798_835

1065.0

Repeat

Pumilio 3

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000338086

-1

836_871

1065.0

Repeat

Pumilio 4

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000338086

-1

872_907

1065.0

Repeat

Pumilio 5

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000338086

-1

908_943

1065.0

Repeat

Pumilio 6

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000338086

-1

944_979

1065.0

Repeat

Pumilio 7

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000338086

-1

983_1022

1065.0

Repeat

Pumilio 8

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000361078

-1

726_761

1067.0

Repeat

Pumilio 1

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000361078

-1

762_797

1067.0

Repeat

Pumilio 2

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000361078

-1

798_835

1067.0

Repeat

Pumilio 3

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000361078

-1

836_871

1067.0

Repeat

Pumilio 4

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000361078

-1

872_907

1067.0

Repeat

Pumilio 5

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000361078

-1

908_943

1067.0

Repeat

Pumilio 6

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000361078

-1

944_979

1067.0

Repeat

Pumilio 7

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000361078

-1

983_1022

1067.0

Repeat

Pumilio 8

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000403432

726_761

1065.0

Repeat

Pumilio 1

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000403432

762_797

1065.0

Repeat

Pumilio 2

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000403432

798_835

1065.0

Repeat

Pumilio 3

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000403432

836_871

1065.0

Repeat

Pumilio 4

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000403432

872_907

1065.0

Repeat

Pumilio 5

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000403432

908_943

1065.0

Repeat

Pumilio 6

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000403432

944_979

1065.0

Repeat

Pumilio 7

Tgene

PUM2

chr2:20251171

chr2:20527139

ENST00000403432

983_1022

1065.0

Repeat

Pumilio 8

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

LAPTM4A

chr2:20251171

chr2:20527139

ENST00000175091

226_229

234.0

Compositional bias

Note=Poly-Pro

Hgene

LAPTM4A

chr2:20251171

chr2:20527139

ENST00000175091

108_128

234.0

Transmembrane

Helical

Hgene

LAPTM4A

chr2:20251171

chr2:20527139

ENST00000175091

160_180

234.0

Transmembrane

Helical

Hgene

LAPTM4A

chr2:20251171

chr2:20527139

ENST00000175091

29_49

234.0

Transmembrane

Helical

Hgene

LAPTM4A

chr2:20251171

chr2:20527139

ENST00000175091

82_102

234.0

Transmembrane

Helical

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Fusion Gene Sequence for LAPTM4A-PUM2

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>44049_44049_1_LAPTM4A-PUM2_LAPTM4A_chr2_20251171_ENST00000175091_PUM2_chr2_20527139_ENST00000319801_length(transcript)=6499nt_BP=619nt
ATCCAGTACGTGGCACACATTGCTCAGAAAAGCCCCTTGTGCCCGCTTTCTGCCATCCGCGCTGTCTCGTGTCTCCCTTTTTCCATTAAA
TGCCTCTTTTCTTGCGGGTCTCATCTCGGGAATAGTGCACTACGGGGACATACCTATCCCCAACTATCCTAGGCCCGAGAACCAGCCCTT
GCCTTCGCGTAACAGGCGGAGACTCGCTGAGGCGAGTTGCACTTCTAATTGGGCGTGAGGTCTTGTCAATCCCCAAGTTCTTCCAATCAG
AAGTCCGGTCCATCCAGCCTTCCGCTCCCCATTGGCCTGTGTGGAGGAAGAGGGGTGGGTAAGCCGAAGTCGCTGCGCTCAGTGCGCAGG
CGCGAAGAAGCTGGCAGGGGCACGAGCCGGGGGCGGGTTTGAAGACGCGTCGTTGGGTTTTGGAGGCCGTGAAACAGCCGTTTGAGTTTG
GCTGCGGGTGGAGAACGTTTGTCAGGGGCCCGGCCAAGAAGGAGGCCCGCCTGTTACGATGGTGTCCATGAGTTTCAAGCGGAACCGCAG
TGACCGGTTCTACAGCACCCGGTGCTGCGGCTGTTGCCATGTCCGCACCGGGACGATCATCCTGGGGACCTGGTACATGAACAGGTTTGA
TCTGTGGATGAAATGAATCATGATTTTCAAGCTCTTGCATTAGAATCTCGGGGAATGGGAGAGCTTTTGCCTACCAAAAAGTTTTGGGAA
CCTGATGATTCAACAAAAGATGGACAAAAAGGCATATTTCTTGGGGATGATGAATGGAGAGAGACTGCATGGGGAGCTTCTCACCATTCA
ATGTCCCAGCCTATTATGGTACAGAGAAGATCTGGACAGGGTTTTCATGGAAACAGTGAAGTAAATGCAATACTGTCTCCGCGATCAGAA
AGTGGAGGCCTTGGTGTGAGCATGGTAGAATATGTATTAAGTTCTTCTCCTGCTGATAAATTGGATTCTCGATTTAGGAAGGGAAATTTT
GGCACTAGAGATGCTGAAACAGATGGACCTGAGAAAGGAGATCAAAAAGGCAAGGCTTCTCCATTTGAGGAGGACCAAAACAGAGATCTT
AAACAAGGAGATGATGATGATTCTAAAATAAATGGCAGAGGTTTGCCAAATGGAATGGATGCCGATTGCAAAGATTTTAATCGTACTCCT
GGAAGTCGTCAAGCCTCTCCAACTGAAGTAGTTGAGCGCTTGGGCCCCAATACTAATCCCTCAGAAGGACTGGGGCCTCTTCCTAATCCT
ACAGCTAATAAACCACTTGTTGAAGAATTTTCAAATCCTGAAACTCAGAATCTGGATGCCATGGAACAAGTTGGTCTGGAATCCTTACAG
TTTGACTATCCTGGTAATCAGGTACCAATGGACTCTTCAGGAGCTACTGTAGGCCTTTTTGACTACAATTCCCAGCAGCAGCTCTTTCAG
AGGACTAATGCACTAACAGTTCAACAGTTAACTGCAGCTCAACAGCAGCAATATGCATTAGCAGCAGCTCAGCAGCCACATATAGCTGGT
GTATTCTCAGCAGGCCTTGCTCCAGCTGCATTTGTGCCAAATCCATACATTATTAGTGCTGCTCCTCCAGGGACCGATCCGTATACTGCA
GCAGGATTGGCTGCAGCAGCTACATTAGCAGGTCCAGCAGTGGTTCCACCTCAGTATTACGGCGTTCCATGGGGGGTGTATCCAGCCAAC
TTATTTCAGCAGCAAGCTGCAGCTGCGGCAAATAACACAGCCAGTCAGCAAGCAGCATCACAAGCTCAGCCTGGACAGCAACAGGTTCTC
CGTGCTGGAGCAGGTCAGCGTCCTCTTACTCCCAATCAGGGTCAGCAAGGGCAGCAAGCAGAATCACTTGCGGCAGCTGCAGCAGCAAAT
CCAACATTGGCTTTTGGTCAGGGTCTTGCTACTGGCATGCCAGGCTATCAAGTACTAGCTCCAACTGCCTATTATGATCAGACTGGTGCC
TTAGTGGTTGGCCCTGGAGCAAGGACTGGCCTTGGAGCTCCAGTTCGGTTAATGGCTCCAACACCTGTTTTAATTAGTTCAGCAGCAGCA
CAAGCTGCAGCAGCAGCAGCAGCTGGAGGAACTGCAAGTAGCCTTACAGGCAGCACAAATGGTCTGTTTCGGCCAATTGGCACTCAGCCA
CCACAGCAGCAGCAACAGCAGCCAAGCACTAATCTGCAATCTAATTCATTTTATGGAAGCAGTTCTTTGACTAATAGCTCCCAGAGTAGT
TCTTTATTTTCTCATGGACCTGGTCAACCTGGAAGTACATCTCTTGGCTTTGGAAGTGGTAACTCTTTGGGTGCTGCTATAGGCTCAGCC
CTCAGTGGATTTGGTTCATCAGGAGGACTGACAAATGGTAGTGGTCGATATATCTCTGCAGCACCTGGAGCAGAAGCAAAATATCGAAGT
GCTTCAAGCACTTCCAGTCTATTTAGCTCCAGCAGCCAGCTCTTTCCTCCTTCCCGGCTTCGGTATAATAGGTCTGATATTATGCCTTCT
GGCCGCAGTAGATTATTGGAAGATTTCAGAAACAACCGCTTCCCAAACCTTCAGCTTAGAGACTTGATTGGACATATAGTTGAGTTTTCT
CAAGACCAGCATGGTTCTAGATTCATACAGCAAAAACTAGAGAGAGCTACTCCAGCTGAGCGACAGATGGTATTTAATGAAATTCTGCAA
GCAGCCTATCAATTAATGACTGATGTTTTTGGCAACTATGTTATACAGAAGTTTTTTGAGTTTGGGAGTCTGGATCAAAAATTAGCCCTG
GCTACTCGTATTCGTGGTCATGTTCTACCCTTAGCCTTGCAGATGTATGGCTGCCGCGTTATTCAGAAAGCATTAGAATCTATTTCTTCT
GACCAGCAGGTAATTAGTGAAATGGTAAAGGAGCTGGATGGTCATGTGCTCAAATGTGTGAAAGATCAGAATGGAAACCATGTTGTACAA
AAATGTATCGAATGTGTTCAGCCACAGTCACTACAGTTCATCATTGATGCTTTCAAGGGACAAGTATTTGTGCTTTCAACTCATCCTTAT
GGCTGCAGAGTAATTCAGCGCATCCTAGAGCATTGCACTGCAGAACAGACCTTACCTATCTTAGAAGAACTCCACCAACATACAGAGCAG
TTGGTACAGGATCAGTATGGCAATTATGTTATTCAGCATGTACTGGAACACGGTCGACCTGAAGACAAGAGCAAAATTGTTTCCGAAATC
AGGGGAAAGGTTTTAGCCCTGAGTCAACACAAATTTGCCAGCAATGTAGTAGAAAAGTGTGTTACTCATGCCTCCCGTGCTGAGAGAGCT
TTACTGATTGACGAGGTTTGCTGCCAGAATGATGGTCCTCACAGTGCCTTATACACCATGATGAAGGACCAGTATGCCAATTACGTGGTT
CAAAAGATGATTGATATGGCTGAACCTGCTCAGAGAAAGATAATCATGCACAAGATTCGACCTCACATTACTACTTTGCGCAAATACACA
TACGGGAAGCATATACTGGCCAAGTTGGAAAAGTATTATTTGAAGAATAGCCCGGACCTAGGACCTATTGGAGGACCACCAAATGGAATG
CTGTAAATTACAGGAGCAAGAGAAAGAAGATAATTTAACCATGTGAAAAGAATTTTTTTGTGTGTGAATTATCAAAACACAACTCAACTA
TGAATCTTCAATTTTTTTTTAAAGCAAAACTATTTATTGACTTTATTCATCCATTTGTAAATTTTTTAAGGTTCTTGTGTATATTTGGGG
GGTGGGGGATGAATTATAAATTATATTCAGCCCTGAGTGGAGACCTATCAGATTGGATTGCTGGCAAAGCACAGAATGCCTGTATATGAT
GTAACTGTATCAAAAATAAAAAGCTGTCACATATTTTGTAAATTTTTACCTTGTAAAGTCACAAAAATAGTTTTTAAAGGAAAAAGTACA
GTATTCTTTTAATAAACTGGCTCACAGTCTGGTAGGTCTACAACCCCATAGCACAACAGGTTTATAGAGATGTATATAGAATTATAGTCC
TTATTTTTTTCCTTTGCGTGAAACCTTTTATAACAGATTAACAATCAACTGCATAAATATTATTAATATTTTAAAAAGAGTTAAGTTGTA
TTTTGATAATTCACAAACTATCATGCAAATAACGAGTAAGTAGACAAGAATAAAGTGGTTTGAGATGAAAAGAACCTAACATTATTTACA
GTAGATGTGGTTTTAATACAATTACTGCCCTAAAATGTCTCTGGCAATGTACAGAAATATTGTATATACTTACATATGTAATTGTTGTAA
GAGTTAAATACAAAATCATGGTGACACTTCCAATTAAGTGCACTAAATGAAAAGTTAAGTCACTTATTAACTTTTCAGTTTGGTTTGCAA
TGAGAAAGAGTGGAAATTTGTATTTTGTTTTGCTTATAGAATTACAGACATGTTGAGGAAGTGTTGAGCTTTATTTTGCTTTTTCATAGA
GGCAGAAAGTAGGAACCAGATAGAGATGAAAAGGGGCCACTGAAAAGTGAATTTGATAGCTCAGCATTTAAGCATGATTACATATTCAGA
TAGCTCTTTTTGCTTTCTATAAATATATGCATTGTGTGTGTAGTAATAGATGTAAGTTTACACTTTGAAAGGAAATCTTGTTTCAATGTT
TATTATAAAAGCCTTGCTAATTTAGTAGTGATGCTTTCCTTGGTTGTACAGGTGTACATTTGTAAACCTTCATGCTGTAAATGGAATTTG
TTTTATCTCTTTGGGATACATTTGCATTTTAGTGTACATTTACGTCCCTGCCCTCTTTGACCTGGCAATATAGTGTTGTATAATGTAAAT
TTATTTCTCCAAATCGAGAGTGATTTTTTAAAAATTTTTTATCTTTATATGGTTTCAGAAGTATGAACCAGCTTTCTTTTTATTATTGTG
AGATCATTTTGTTTTATAACATAGTTGTTGACTGTTAATATGGACCTGCTAGAATTTGGATCACTTTCAATTGAAGTCAGGGTATTGTGC
ATAATAGAAAGTATTGGACTGAGATATTTGGTTACCATGGAGGCCAATGCTTTTTTCATCTTATTAAATGTGATGTGACTTTTTTCTTTG
TACAGAAGAGTACTGTATTTTTGAATAGCCTACTCCCAAGTAAGAGCAAATCTGTATGATAACATTTTTTCCTCTGGACATAAGACATAA
CAGTAACACGATGTACATTTACAAGCGGCCTTATGTACATTTCCCAACAATCTTTTTAAGGCAAAATTGTGACCATATGTGTATAATTAA
AATCGTTTTTAATCCTTTGCCTATGAAAATATTTTGGAAAAAAACTTGCTGTGTATATTCAGTTTCTGAAAGATAAAGAAAGTGCTTTGT
ATTTTGTTGAAGTCAGTATTTTGTATAAACATTTATGTTGACCCACTTATGTTCAGTGCTGAAAACTAAAATGAACATGCTATTCTGTCA
GCTGAATATGGAAGAGATCTTTTTTTACTAGAGATCTGCAGAAGAAACGCAATCTTCTGAGCACAATATGGAATCTAAAGGTTTTATCAC
TTAGTTGTTCATATTATGAACCTAAAAATAATGGCATAAAGTTTGGGGATGCCAGGCATACTTTTTCATGTTTGGTGTTGAGTTATTTTA
CTTTTCTAACCCAACATTCCTTGGTGAGACCATTAAATCCAAACACTTGTCACCGTTCCTTCTCATAGTCACTCTGGGTCATCAGCATGT
CCCAGTCACTGCAGCAACGCCTTGTGTTTGTTTCATTTTTTTAAAACCCACACAAAGCCGCTGTCTCACTTTTTCCTACTTTACCAACCT
CAGAGTATTTCGGCCCGTATCGAACTTTTGTTCTCAGTATCAGCCCATGGTTTCAGGATCAAAGCTGTCATGTTGGAGATTGGTAATGGC
TTTCCTGTCTTTGTACAGTTGAATTCCTAGTCTTCCTTCATCCTTGCCCTCTGTTGGCACAGGCATTATCTCTGCAATTTTAGAAAATGA
CAAGTAGAGAATACTACATTGAGAAACTAAACCCTCTTCTTGGGGTCCTGATACTCATTCCCATTTGTCCCAGTGCTGACAACCCAATCT
TCCCAATACTTTCAGGCCTGCTCTACAAAAGTACCTGTTCTTGTAGAAATTTTACAGTCTGCCATTTTGGGTGCCCACCCCAATTTTTAC
CTTTTAGTAAGTTGGCATGAAATTTTGGTAAAATCTGAAAATCACATTTCAGAATAAAACAATTGGGCAAAACTACCTAGGCTTTACTCT
TGAGTGTCTCCTTTTGATAGGGATTGTTTCTGGACCAGTTTGTCTAAGTCCTGGCTCTTATTGGTTCATATGAAATAATGTTAACTTCAC
TTCTTTGTATATTATGTATAAATTAGAAAATGAAAAATGTGTGAATAACATTGTATGAAATAAACCTGGTCTTGTGTTTTTCTCTAGATA

>44049_44049_1_LAPTM4A-PUM2_LAPTM4A_chr2_20251171_ENST00000175091_PUM2_chr2_20527139_ENST00000319801_length(amino acids)=987AA_BP=
MNHDFQALALESRGMGELLPTKKFWEPDDSTKDGQKGIFLGDDEWRETAWGASHHSMSQPIMVQRRSGQGFHGNSEVNAILSPRSESGGL
GVSMVEYVLSSSPADKLDSRFRKGNFGTRDAETDGPEKGDQKGKASPFEEDQNRDLKQGDDDDSKINGRGLPNGMDADCKDFNRTPGSRQ
ASPTEVVERLGPNTNPSEGLGPLPNPTANKPLVEEFSNPETQNLDAMEQVGLESLQFDYPGNQVPMDSSGATVGLFDYNSQQQLFQRTNA
LTVQQLTAAQQQQYALAAAQQPHIAGVFSAGLAPAAFVPNPYIISAAPPGTDPYTAAGLAAAATLAGPAVVPPQYYGVPWGVYPANLFQQ
QAAAAANNTASQQAASQAQPGQQQVLRAGAGQRPLTPNQGQQGQQAESLAAAAAANPTLAFGQGLATGMPGYQVLAPTAYYDQTGALVVG
PGARTGLGAPVRLMAPTPVLISSAAAQAAAAAAAGGTASSLTGSTNGLFRPIGTQPPQQQQQQPSTNLQSNSFYGSSSLTNSSQSSSLFS
HGPGQPGSTSLGFGSGNSLGAAIGSALSGFGSSGGLTNGSGRYISAAPGAEAKYRSASSTSSLFSSSSQLFPPSRLRYNRSDIMPSGRSR
LLEDFRNNRFPNLQLRDLIGHIVEFSQDQHGSRFIQQKLERATPAERQMVFNEILQAAYQLMTDVFGNYVIQKFFEFGSLDQKLALATRI
RGHVLPLALQMYGCRVIQKALESISSDQQVISEMVKELDGHVLKCVKDQNGNHVVQKCIECVQPQSLQFIIDAFKGQVFVLSTHPYGCRV
IQRILEHCTAEQTLPILEELHQHTEQLVQDQYGNYVIQHVLEHGRPEDKSKIVSEIRGKVLALSQHKFASNVVEKCVTHASRAERALLID

--------------------------------------------------------------
>44049_44049_2_LAPTM4A-PUM2_LAPTM4A_chr2_20251171_ENST00000175091_PUM2_chr2_20527139_ENST00000338086_length(transcript)=6731nt_BP=619nt
ATCCAGTACGTGGCACACATTGCTCAGAAAAGCCCCTTGTGCCCGCTTTCTGCCATCCGCGCTGTCTCGTGTCTCCCTTTTTCCATTAAA
TGCCTCTTTTCTTGCGGGTCTCATCTCGGGAATAGTGCACTACGGGGACATACCTATCCCCAACTATCCTAGGCCCGAGAACCAGCCCTT
GCCTTCGCGTAACAGGCGGAGACTCGCTGAGGCGAGTTGCACTTCTAATTGGGCGTGAGGTCTTGTCAATCCCCAAGTTCTTCCAATCAG
AAGTCCGGTCCATCCAGCCTTCCGCTCCCCATTGGCCTGTGTGGAGGAAGAGGGGTGGGTAAGCCGAAGTCGCTGCGCTCAGTGCGCAGG
CGCGAAGAAGCTGGCAGGGGCACGAGCCGGGGGCGGGTTTGAAGACGCGTCGTTGGGTTTTGGAGGCCGTGAAACAGCCGTTTGAGTTTG
GCTGCGGGTGGAGAACGTTTGTCAGGGGCCCGGCCAAGAAGGAGGCCCGCCTGTTACGATGGTGTCCATGAGTTTCAAGCGGAACCGCAG
TGACCGGTTCTACAGCACCCGGTGCTGCGGCTGTTGCCATGTCCGCACCGGGACGATCATCCTGGGGACCTGGTACATGAACAGGTTTGA
TCTGTGGATGAAATGAATCATGATTTTCAAGCTCTTGCATTAGAATCTCGGGGAATGGGAGAGCTTTTGCCTACCAAAAAGTTTTGGGAA
CCTGATGATTCAACAAAAGATGGACAAAAAGGCATATTTCTTGGGGATGATGAATGGAGAGAGACTGCATGGGGAGCTTCTCACCATTCA
ATGTCCCAGCCTATTATGGTACAGAGAAGATCTGGACAGGGTTTTCATGGAAACAGTGAAGTAAATGCAATACTGTCTCCGCGATCAGAA
AGTGGAGGCCTTGGTGTGAGCATGGTAGAATATGTATTAAGTTCTTCTCCTGCTGATAAATTGGATTCTCGATTTAGGAAGGGAAATTTT
GGCACTAGAGATGCTGAAACAGATGGACCTGAGAAAGGAGATCAAAAAGGCAAGGCTTCTCCATTTGAGGAGGACCAAAACAGAGATCTT
AAACAAGGAGATGATGATGATTCTAAAATAAATGGCAGAGGTTTGCCAAATGGAATGGATGCCGATTGCAAAGATTTTAATCGTACTCCT
GGAAGTCGTCAAGCCTCTCCAACTGAAGTAGTTGAGCGCTTGGGCCCCAATACTAATCCCTCAGAAGGACTGGGGCCTCTTCCTAATCCT
ACAGCTAATAAACCACTTGTTGAAGAATTTTCAAATCCTGAAACTCAGAATCTGGATGCCATGGAACAAGTTGGTCTGGAATCCTTACAG
TTTGACTATCCTGGTAATCAGGTACCAATGGACTCTTCAGGAGCTACTGTAGGCCTTTTTGACTACAATTCCCAGCAGCAGCTCTTTCAG
AGGACTAATGCACTAACAGTTCAACAGTTAACTGCAGCTCAACAGCAGCAATATGCATTAGCAGCAGCTCAGCAGCCACATATAGCTGGT
GTATTCTCAGCAGGCCTTGCTCCAGCTGCATTTGTGCCAAATCCATACATTATTAGTGCTGCTCCTCCAGGGACCGATCCGTATACTGCA
GCAGGATTGGCTGCAGCAGCTACATTAGCAGGTCCAGCAGTGGTTCCACCTCAGTATTACGGCGTTCCATGGGGGGTGTATCCAGCCAAC
TTATTTCAGCAGCAAGCTGCAGCTGCGGCAAATAACACAGCCAGTCAGCAAGCAGCATCACAAGCTCAGCCTGGACAGCAACAGGTTCTC
CGTGCTGGAGCAGGTCAGCGTCCTCTTACTCCCAATCAGGGTCAGCAAGGGCAGCAAGCAGAATCACTTGCGGCAGCTGCAGCAGCAAAT
CCAACATTGGCTTTTGGTCAGGGTCTTGCTACTGGCATGCCAGGCTATCAAGTACTAGCTCCAACTGCCTATTATGATCAGACTGGTGCC
TTAGTGGTTGGCCCTGGAGCAAGGACTGGCCTTGGAGCTCCAGTTCGGTTAATGGCTCCAACACCTGTTTTAATTAGTTCAGCAGCAGCA
CAAGCTGCAGCAGCAGCAGCAGCTGGAGGAACTGCAAGTAGCCTTACAGGCAGCACAAATGGTCTGTTTCGGCCAATTGGCACTCAGCCA
CCACAGCAGCAGCAACAGCAGCCAAGCACTAATCTGCAATCTAATTCATTTTATGGAAGCAGTTCTTTGACTAATAGCTCCCAGAGTAGT
TCTTTATTTTCTCATGGACCTGGTCAACCTGGAAGTACATCTCTTGGCTTTGGAAGTGGTAACTCTTTGGGTGCTGCTATAGGCTCAGCC
CTCAGTGGATTTGGTTCATCAGTTGGCAGTTCTGCAAGTAGTAGTGCCACAAGGAGAGAGTCTCTATCTACTAGCTCTGACTTGTACAAA
AGATCTAGTAGCAGCCTAGCACCCATAGGGCAACCATTTTACAATAGTCTGGGATTTTCCTCCTCTCCAAGTCCAATAGGCATGCCTCTG
CCAAGCCAAACTCCAGGACATTCACTTACGCCACCGCCATCACTTTCATCACATGGATCCTCATCCAGTTTGCATTTAGGAGGACTGACA
AATGGTAGTGGTCGATATATCTCTGCAGCACCTGGAGCAGAAGCAAAATATCGAAGTGCTTCAAGCACTTCCAGTCTATTTAGCTCCAGC
AGCCAGCTCTTTCCTCCTTCCCGGCTTCGGTATAATAGGTCTGATATTATGCCTTCTGGCCGCAGTAGATTATTGGAAGATTTCAGAAAC
AACCGCTTCCCAAACCTTCAGCTTAGAGACTTGATTGGACATATAGTTGAGTTTTCTCAAGACCAGCATGGTTCTAGATTCATACAGCAA
AAACTAGAGAGAGCTACTCCAGCTGAGCGACAGATGGTATTTAATGAAATTCTGCAAGCAGCCTATCAATTAATGACTGATGTTTTTGGC
AACTATGTTATACAGAAGTTTTTTGAGTTTGGGAGTCTGGATCAAAAATTAGCCCTGGCTACTCGTATTCGTGGTCATGTTCTACCCTTA
GCCTTGCAGATGTATGGCTGCCGCGTTATTCAGAAAGCATTAGAATCTATTTCTTCTGACCAGCAGAGTGAAATGGTAAAGGAGCTGGAT
GGTCATGTGCTCAAATGTGTGAAAGATCAGAATGGAAACCATGTTGTACAAAAATGTATCGAATGTGTTCAGCCACAGTCACTACAGTTC
ATCATTGATGCTTTCAAGGGACAAGTATTTGTGCTTTCAACTCATCCTTATGGCTGCAGAGTAATTCAGCGCATCCTAGAGCATTGCACT
GCAGAACAGACCTTACCTATCTTAGAAGAACTCCACCAACATACAGAGCAGTTGGTACAGGATCAGTATGGCAATTATGTTATTCAGCAT
GTACTGGAACACGGTCGACCTGAAGACAAGAGCAAAATTGTTTCCGAAATCAGGGGAAAGGTTTTAGCCCTGAGTCAACACAAATTTGCC
AGCAATGTAGTAGAAAAGTGTGTTACTCATGCCTCCCGTGCTGAGAGAGCTTTACTGATTGACGAGGTTTGCTGCCAGAATGATGGTCCT
CACAGTGCCTTATACACCATGATGAAGGACCAGTATGCCAATTACGTGGTTCAAAAGATGATTGATATGGCTGAACCTGCTCAGAGAAAG
ATAATCATGCACAAGATTCGACCTCACATTACTACTTTGCGCAAATACACATACGGGAAGCATATACTGGCCAAGTTGGAAAAGTATTAT
TTGAAGAATAGCCCGGACCTAGGACCTATTGGAGGACCACCAAATGGAATGCTGTAAATTACAGGAGCAAGAGAAAGAAGATAATTTAAC
CATGTGAAAAGAATTTTTTTGTGTGTGAATTATCAAAACACAACTCAACTATGAATCTTCAATTTTTTTTTAAAGCAAAACTATTTATTG
ACTTTATTCATCCATTTGTAAATTTTTTAAGGTTCTTGTGTATATTTGGGGGGTGGGGGATGAATTATAAATTATATTCAGCCCTGAGTG
GAGACCTATCAGATTGGATTGCTGGCAAAGCACAGAATGCCTGTATATGATGTAACTGTATCAAAAATAAAAAGCTGTCACATATTTTGT
AAATTTTTACCTTGTAAAGTCACAAAAATAGTTTTTAAAGGAAAAAGTACAGTATTCTTTTAATAAACTGGCTCACAGTCTGGTAGGTCT
ACAACCCCATAGCACAACAGGTTTATAGAGATGTATATAGAATTATAGTCCTTATTTTTTTCCTTTGCGTGAAACCTTTTATAACAGATT
AACAATCAACTGCATAAATATTATTAATATTTTAAAAAGAGTTAAGTTGTATTTTGATAATTCACAAACTATCATGCAAATAACGAGTAA
GTAGACAAGAATAAAGTGGTTTGAGATGAAAAGAACCTAACATTATTTACAGTAGATGTGGTTTTAATACAATTACTGCCCTAAAATGTC
TCTGGCAATGTACAGAAATATTGTATATACTTACATATGTAATTGTTGTAAGAGTTAAATACAAAATCATGGTGACACTTCCAATTAAGT
GCACTAAATGAAAAGTTAAGTCACTTATTAACTTTTCAGTTTGGTTTGCAATGAGAAAGAGTGGAAATTTGTATTTTGTTTTGCTTATAG
AATTACAGACATGTTGAGGAAGTGTTGAGCTTTATTTTGCTTTTTCATAGAGGCAGAAAGTAGGAACCAGATAGAGATGAAAAGGGGCCA
CTGAAAAGTGAATTTGATAGCTCAGCATTTAAGCATGATTACATATTCAGATAGCTCTTTTTGCTTTCTATAAATATATGCATTGTGTGT
GTAGTAATAGATGTAAGTTTACACTTTGAAAGGAAATCTTGTTTCAATGTTTATTATAAAAGCCTTGCTAATTTAGTAGTGATGCTTTCC
TTGGTTGTACAGGTGTACATTTGTAAACCTTCATGCTGTAAATGGAATTTGTTTTATCTCTTTGGGATACATTTGCATTTTAGTGTACAT
TTACGTCCCTGCCCTCTTTGACCTGGCAATATAGTGTTGTATAATGTAAATTTATTTCTCCAAATCGAGAGTGATTTTTTAAAAATTTTT
TATCTTTATATGGTTTCAGAAGTATGAACCAGCTTTCTTTTTATTATTGTGAGATCATTTTGTTTTATAACATAGTTGTTGACTGTTAAT
ATGGACCTGCTAGAATTTGGATCACTTTCAATTGAAGTCAGGGTATTGTGCATAATAGAAAGTATTGGACTGAGATATTTGGTTACCATG
GAGGCCAATGCTTTTTTCATCTTATTAAATGTGATGTGACTTTTTTCTTTGTACAGAAGAGTACTGTATTTTTGAATAGCCTACTCCCAA
GTAAGAGCAAATCTGTATGATAACATTTTTTCCTCTGGACATAAGACATAACAGTAACACGATGTACATTTACAAGCGGCCTTATGTACA
TTTCCCAACAATCTTTTTAAGGCAAAATTGTGACCATATGTGTATAATTAAAATCGTTTTTAATCCTTTGCCTATGAAAATATTTTGGAA
AAAAACTTGCTGTGTATATTCAGTTTCTGAAAGATAAAGAAAGTGCTTTGTATTTTGTTGAAGTCAGTATTTTGTATAAACATTTATGTT
GACCCACTTATGTTCAGTGCTGAAAACTAAAATGAACATGCTATTCTGTCAGCTGAATATGGAAGAGATCTTTTTTTACTAGAGATCTGC
AGAAGAAACGCAATCTTCTGAGCACAATATGGAATCTAAAGGTTTTATCACTTAGTTGTTCATATTATGAACCTAAAAATAATGGCATAA
AGTTTGGGGATGCCAGGCATACTTTTTCATGTTTGGTGTTGAGTTATTTTACTTTTCTAACCCAACATTCCTTGGTGAGACCATTAAATC
CAAACACTTGTCACCGTTCCTTCTCATAGTCACTCTGGGTCATCAGCATGTCCCAGTCACTGCAGCAACGCCTTGTGTTTGTTTCATTTT
TTTAAAACCCACACAAAGCCGCTGTCTCACTTTTTCCTACTTTACCAACCTCAGAGTATTTCGGCCCGTATCGAACTTTTGTTCTCAGTA
TCAGCCCATGGTTTCAGGATCAAAGCTGTCATGTTGGAGATTGGTAATGGCTTTCCTGTCTTTGTACAGTTGAATTCCTAGTCTTCCTTC
ATCCTTGCCCTCTGTTGGCACAGGCATTATCTCTGCAATTTTAGAAAATGACAAGTAGAGAATACTACATTGAGAAACTAAACCCTCTTC
TTGGGGTCCTGATACTCATTCCCATTTGTCCCAGTGCTGACAACCCAATCTTCCCAATACTTTCAGGCCTGCTCTACAAAAGTACCTGTT
CTTGTAGAAATTTTACAGTCTGCCATTTTGGGTGCCCACCCCAATTTTTACCTTTTAGTAAGTTGGCATGAAATTTTGGTAAAATCTGAA
AATCACATTTCAGAATAAAACAATTGGGCAAAACTACCTAGGCTTTACTCTTGAGTGTCTCCTTTTGATAGGGATTGTTTCTGGACCAGT
TTGTCTAAGTCCTGGCTCTTATTGGTTCATATGAAATAATGTTAACTTCACTTCTTTGTATATTATGTATAAATTAGAAAATGAAAAATG

>44049_44049_2_LAPTM4A-PUM2_LAPTM4A_chr2_20251171_ENST00000175091_PUM2_chr2_20527139_ENST00000338086_length(amino acids)=1064AA_BP=
MNHDFQALALESRGMGELLPTKKFWEPDDSTKDGQKGIFLGDDEWRETAWGASHHSMSQPIMVQRRSGQGFHGNSEVNAILSPRSESGGL
GVSMVEYVLSSSPADKLDSRFRKGNFGTRDAETDGPEKGDQKGKASPFEEDQNRDLKQGDDDDSKINGRGLPNGMDADCKDFNRTPGSRQ
ASPTEVVERLGPNTNPSEGLGPLPNPTANKPLVEEFSNPETQNLDAMEQVGLESLQFDYPGNQVPMDSSGATVGLFDYNSQQQLFQRTNA
LTVQQLTAAQQQQYALAAAQQPHIAGVFSAGLAPAAFVPNPYIISAAPPGTDPYTAAGLAAAATLAGPAVVPPQYYGVPWGVYPANLFQQ
QAAAAANNTASQQAASQAQPGQQQVLRAGAGQRPLTPNQGQQGQQAESLAAAAAANPTLAFGQGLATGMPGYQVLAPTAYYDQTGALVVG
PGARTGLGAPVRLMAPTPVLISSAAAQAAAAAAAGGTASSLTGSTNGLFRPIGTQPPQQQQQQPSTNLQSNSFYGSSSLTNSSQSSSLFS
HGPGQPGSTSLGFGSGNSLGAAIGSALSGFGSSVGSSASSSATRRESLSTSSDLYKRSSSSLAPIGQPFYNSLGFSSSPSPIGMPLPSQT
PGHSLTPPPSLSSHGSSSSLHLGGLTNGSGRYISAAPGAEAKYRSASSTSSLFSSSSQLFPPSRLRYNRSDIMPSGRSRLLEDFRNNRFP
NLQLRDLIGHIVEFSQDQHGSRFIQQKLERATPAERQMVFNEILQAAYQLMTDVFGNYVIQKFFEFGSLDQKLALATRIRGHVLPLALQM
YGCRVIQKALESISSDQQSEMVKELDGHVLKCVKDQNGNHVVQKCIECVQPQSLQFIIDAFKGQVFVLSTHPYGCRVIQRILEHCTAEQT
LPILEELHQHTEQLVQDQYGNYVIQHVLEHGRPEDKSKIVSEIRGKVLALSQHKFASNVVEKCVTHASRAERALLIDEVCCQNDGPHSAL

--------------------------------------------------------------
>44049_44049_3_LAPTM4A-PUM2_LAPTM4A_chr2_20251171_ENST00000175091_PUM2_chr2_20527139_ENST00000361078_length(transcript)=6736nt_BP=619nt
ATCCAGTACGTGGCACACATTGCTCAGAAAAGCCCCTTGTGCCCGCTTTCTGCCATCCGCGCTGTCTCGTGTCTCCCTTTTTCCATTAAA
TGCCTCTTTTCTTGCGGGTCTCATCTCGGGAATAGTGCACTACGGGGACATACCTATCCCCAACTATCCTAGGCCCGAGAACCAGCCCTT
GCCTTCGCGTAACAGGCGGAGACTCGCTGAGGCGAGTTGCACTTCTAATTGGGCGTGAGGTCTTGTCAATCCCCAAGTTCTTCCAATCAG
AAGTCCGGTCCATCCAGCCTTCCGCTCCCCATTGGCCTGTGTGGAGGAAGAGGGGTGGGTAAGCCGAAGTCGCTGCGCTCAGTGCGCAGG
CGCGAAGAAGCTGGCAGGGGCACGAGCCGGGGGCGGGTTTGAAGACGCGTCGTTGGGTTTTGGAGGCCGTGAAACAGCCGTTTGAGTTTG
GCTGCGGGTGGAGAACGTTTGTCAGGGGCCCGGCCAAGAAGGAGGCCCGCCTGTTACGATGGTGTCCATGAGTTTCAAGCGGAACCGCAG
TGACCGGTTCTACAGCACCCGGTGCTGCGGCTGTTGCCATGTCCGCACCGGGACGATCATCCTGGGGACCTGGTACATGAACAGGTTTGA
TCTGTGGATGAAATGAATCATGATTTTCAAGCTCTTGCATTAGAATCTCGGGGAATGGGAGAGCTTTTGCCTACCAAAAAGTTTTGGGAA
CCTGATGATTCAACAAAAGATGGACAAAAAGGCATATTTCTTGGGGATGATGAATGGAGAGAGACTGCATGGGGAGCTTCTCACCATTCA
ATGTCCCAGCCTATTATGGTACAGAGAAGATCTGGACAGGGTTTTCATGGAAACAGTGAAGTAAATGCAATACTGTCTCCGCGATCAGAA
AGTGGAGGCCTTGGTGTGAGCATGGTAGAATATGTATTAAGTTCTTCTCCTGCTGATAAATTGGATTCTCGATTTAGGAAGGGAAATTTT
GGCACTAGAGATGCTGAAACAGATGGACCTGAGAAAGGAGATCAAAAAGGCAAGGCTTCTCCATTTGAGGAGGACCAAAACAGAGATCTT
AAACAAGGAGATGATGATGATTCTAAAATAAATGGCAGAGGTTTGCCAAATGGAATGGATGCCGATTGCAAAGATTTTAATCGTACTCCT
GGAAGTCGTCAAGCCTCTCCAACTGAAGTAGTTGAGCGCTTGGGCCCCAATACTAATCCCTCAGAAGGACTGGGGCCTCTTCCTAATCCT
ACAGCTAATAAACCACTTGTTGAAGAATTTTCAAATCCTGAAACTCAGAATCTGGATGCCATGGAACAAGTTGGTCTGGAATCCTTACAG
TTTGACTATCCTGGTAATCAGGTACCAATGGACTCTTCAGGAGCTACTGTAGGCCTTTTTGACTACAATTCCCAGCAGCAGCTCTTTCAG
AGGACTAATGCACTAACAGTTCAACAGTTAACTGCAGCTCAACAGCAGCAATATGCATTAGCAGCAGCTCAGCAGCCACATATAGCTGGT
GTATTCTCAGCAGGCCTTGCTCCAGCTGCATTTGTGCCAAATCCATACATTATTAGTGCTGCTCCTCCAGGGACCGATCCGTATACTGCA
GCAGGATTGGCTGCAGCAGCTACATTAGCAGGTCCAGCAGTGGTTCCACCTCAGTATTACGGCGTTCCATGGGGGGTGTATCCAGCCAAC
TTATTTCAGCAGCAAGCTGCAGCTGCGGCAAATAACACAGCCAGTCAGCAAGCAGCATCACAAGCTCAGCCTGGACAGCAACAGGTTCTC
CGTGCTGGAGCAGGTCAGCGTCCTCTTACTCCCAATCAGGGTCAGCAAGGGCAGCAAGCAGAATCACTTGCGGCAGCTGCAGCAGCAAAT
CCAACATTGGCTTTTGGTCAGGGTCTTGCTACTGGCATGCCAGGCTATCAAGTACTAGCTCCAACTGCCTATTATGATCAGACTGGTGCC
TTAGTGGTTGGCCCTGGAGCAAGGACTGGCCTTGGAGCTCCAGTTCGGTTAATGGCTCCAACACCTGTTTTAATTAGTTCAGCAGCAGCA
CAAGCTGCAGCAGCAGCAGCAGCTGGAGGAACTGCAAGTAGCCTTACAGGCAGCACAAATGGTCTGTTTCGGCCAATTGGCACTCAGCCA
CCACAGCAGCAGCAACAGCAGCCAAGCACTAATCTGCAATCTAATTCATTTTATGGAAGCAGTTCTTTGACTAATAGCTCCCAGAGTAGT
TCTTTATTTTCTCATGGACCTGGTCAACCTGGAAGTACATCTCTTGGCTTTGGAAGTGGTAACTCTTTGGGTGCTGCTATAGGCTCAGCC
CTCAGTGGATTTGGTTCATCAGTTGGCAGTTCTGCAAGTAGTAGTGCCACAAGGAGAGAGTCTCTATCTACTAGCTCTGACTTGTACAAA
AGATCTAGTAGCAGCCTAGCACCCATAGGGCAACCATTTTACAATAGTCTGGGATTTTCCTCCTCTCCAAGTCCAATAGGCATGCCTCTG
CCAAGCCAAACTCCAGGACATTCACTTACGCCACCGCCATCACTTTCATCACATGGATCCTCATCCAGTTTGCATTTAGGAGGACTGACA
AATGGTAGTGGTCGATATATCTCTGCAGCACCTGGAGCAGAAGCAAAATATCGAAGTGCTTCAAGCACTTCCAGTCTATTTAGCTCCAGC
AGCCAGCTCTTTCCTCCTTCCCGGCTTCGGTATAATAGGTCTGATATTATGCCTTCTGGCCGCAGTAGATTATTGGAAGATTTCAGAAAC
AACCGCTTCCCAAACCTTCAGCTTAGAGACTTGATTGGACATATAGTTGAGTTTTCTCAAGACCAGCATGGTTCTAGATTCATACAGCAA
AAACTAGAGAGAGCTACTCCAGCTGAGCGACAGATGGTATTTAATGAAATTCTGCAAGCAGCCTATCAATTAATGACTGATGTTTTTGGC
AACTATGTTATACAGAAGTTTTTTGAGTTTGGGAGTCTGGATCAAAAATTAGCCCTGGCTACTCGTATTCGTGGTCATGTTCTACCCTTA
GCCTTGCAGATGTATGGCTGCCGCGTTATTCAGAAAGCATTAGAATCTATTTCTTCTGACCAGCAGGTAATTAGTGAAATGGTAAAGGAG
CTGGATGGTCATGTGCTCAAATGTGTGAAAGATCAGAATGGAAACCATGTTGTACAAAAATGTATCGAATGTGTTCAGCCACAGTCACTA
CAGTTCATCATTGATGCTTTCAAGGGACAAGTATTTGTGCTTTCAACTCATCCTTATGGCTGCAGAGTAATTCAGCGCATCCTAGAGCAT
TGCACTGCAGAACAGACCTTACCTATCTTAGAAGAACTCCACCAACATACAGAGCAGTTGGTACAGGATCAGTATGGCAATTATGTTATT
CAGCATGTACTGGAACACGGTCGACCTGAAGACAAGAGCAAAATTGTTTCCGAAATCAGGGGAAAGGTTTTAGCCCTGAGTCAACACAAA
TTTGCCAGCAATGTAGTAGAAAAGTGTGTTACTCATGCCTCCCGTGCTGAGAGAGCTTTACTGATTGACGAGGTTTGCTGCCAGAATGAT
GGTCCTCACAGTGCCTTATACACCATGATGAAGGACCAGTATGCCAATTACGTGGTTCAAAAGATGATTGATATGGCTGAACCTGCTCAG
AGAAAGATAATCATGCACAAGATTCGACCTCACATTACTACTTTGCGCAAATACACATACGGGAAGCATATACTGGCCAAGTTGGAAAAG
TATTATTTGAAGAATAGCCCGGACCTAGGACCTATTGGAGGACCACCAAATGGAATGCTGTAAATTACAGGAGCAAGAGAAAGAAGATAA
TTTAACCATGTGAAAAGAATTTTTTTGTGTGTGAATTATCAAAACACAACTCAACTATGAATCTTCAATTTTTTTTTAAAGCAAAACTAT
TTATTGACTTTATTCATCCATTTGTAAATTTTTTAAGGTTCTTGTGTATATTTGGGGGGTGGGGGATGAATTATAAATTATATTCAGCCC
TGAGTGGAGACCTATCAGATTGGATTGCTGGCAAAGCACAGAATGCCTGTATATGATGTAACTGTATCAAAAATAAAAAGCTGTCACATA
TTTTGTAAATTTTTACCTTGTAAAGTCACAAAAATAGTTTTTAAAGGAAAAAGTACAGTATTCTTTTAATAAACTGGCTCACAGTCTGGT
AGGTCTACAACCCCATAGCACAACAGGTTTATAGAGATGTATATAGAATTATAGTCCTTATTTTTTTCCTTTGCGTGAAACCTTTTATAA
CAGATTAACAATCAACTGCATAAATATTATTAATATTTTAAAAAGAGTTAAGTTGTATTTTGATAATTCACAAACTATCATGCAAATAAC
GAGTAAGTAGACAAGAATAAAGTGGTTTGAGATGAAAAGAACCTAACATTATTTACAGTAGATGTGGTTTTAATACAATTACTGCCCTAA
AATGTCTCTGGCAATGTACAGAAATATTGTATATACTTACATATGTAATTGTTGTAAGAGTTAAATACAAAATCATGGTGACACTTCCAA
TTAAGTGCACTAAATGAAAAGTTAAGTCACTTATTAACTTTTCAGTTTGGTTTGCAATGAGAAAGAGTGGAAATTTGTATTTTGTTTTGC
TTATAGAATTACAGACATGTTGAGGAAGTGTTGAGCTTTATTTTGCTTTTTCATAGAGGCAGAAAGTAGGAACCAGATAGAGATGAAAAG
GGGCCACTGAAAAGTGAATTTGATAGCTCAGCATTTAAGCATGATTACATATTCAGATAGCTCTTTTTGCTTTCTATAAATATATGCATT
GTGTGTGTAGTAATAGATGTAAGTTTACACTTTGAAAGGAAATCTTGTTTCAATGTTTATTATAAAAGCCTTGCTAATTTAGTAGTGATG
CTTTCCTTGGTTGTACAGGTGTACATTTGTAAACCTTCATGCTGTAAATGGAATTTGTTTTATCTCTTTGGGATACATTTGCATTTTAGT
GTACATTTACGTCCCTGCCCTCTTTGACCTGGCAATATAGTGTTGTATAATGTAAATTTATTTCTCCAAATCGAGAGTGATTTTTTAAAA
ATTTTTTATCTTTATATGGTTTCAGAAGTATGAACCAGCTTTCTTTTTATTATTGTGAGATCATTTTGTTTTATAACATAGTTGTTGACT
GTTAATATGGACCTGCTAGAATTTGGATCACTTTCAATTGAAGTCAGGGTATTGTGCATAATAGAAAGTATTGGACTGAGATATTTGGTT
ACCATGGAGGCCAATGCTTTTTTCATCTTATTAAATGTGATGTGACTTTTTTCTTTGTACAGAAGAGTACTGTATTTTTGAATAGCCTAC
TCCCAAGTAAGAGCAAATCTGTATGATAACATTTTTTCCTCTGGACATAAGACATAACAGTAACACGATGTACATTTACAAGCGGCCTTA
TGTACATTTCCCAACAATCTTTTTAAGGCAAAATTGTGACCATATGTGTATAATTAAAATCGTTTTTAATCCTTTGCCTATGAAAATATT
TTGGAAAAAAACTTGCTGTGTATATTCAGTTTCTGAAAGATAAAGAAAGTGCTTTGTATTTTGTTGAAGTCAGTATTTTGTATAAACATT
TATGTTGACCCACTTATGTTCAGTGCTGAAAACTAAAATGAACATGCTATTCTGTCAGCTGAATATGGAAGAGATCTTTTTTTACTAGAG
ATCTGCAGAAGAAACGCAATCTTCTGAGCACAATATGGAATCTAAAGGTTTTATCACTTAGTTGTTCATATTATGAACCTAAAAATAATG
GCATAAAGTTTGGGGATGCCAGGCATACTTTTTCATGTTTGGTGTTGAGTTATTTTACTTTTCTAACCCAACATTCCTTGGTGAGACCAT
TAAATCCAAACACTTGTCACCGTTCCTTCTCATAGTCACTCTGGGTCATCAGCATGTCCCAGTCACTGCAGCAACGCCTTGTGTTTGTTT
CATTTTTTTAAAACCCACACAAAGCCGCTGTCTCACTTTTTCCTACTTTACCAACCTCAGAGTATTTCGGCCCGTATCGAACTTTTGTTC
TCAGTATCAGCCCATGGTTTCAGGATCAAAGCTGTCATGTTGGAGATTGGTAATGGCTTTCCTGTCTTTGTACAGTTGAATTCCTAGTCT
TCCTTCATCCTTGCCCTCTGTTGGCACAGGCATTATCTCTGCAATTTTAGAAAATGACAAGTAGAGAATACTACATTGAGAAACTAAACC
CTCTTCTTGGGGTCCTGATACTCATTCCCATTTGTCCCAGTGCTGACAACCCAATCTTCCCAATACTTTCAGGCCTGCTCTACAAAAGTA
CCTGTTCTTGTAGAAATTTTACAGTCTGCCATTTTGGGTGCCCACCCCAATTTTTACCTTTTAGTAAGTTGGCATGAAATTTTGGTAAAA
TCTGAAAATCACATTTCAGAATAAAACAATTGGGCAAAACTACCTAGGCTTTACTCTTGAGTGTCTCCTTTTGATAGGGATTGTTTCTGG
ACCAGTTTGTCTAAGTCCTGGCTCTTATTGGTTCATATGAAATAATGTTAACTTCACTTCTTTGTATATTATGTATAAATTAGAAAATGA

>44049_44049_3_LAPTM4A-PUM2_LAPTM4A_chr2_20251171_ENST00000175091_PUM2_chr2_20527139_ENST00000361078_length(amino acids)=1066AA_BP=
MNHDFQALALESRGMGELLPTKKFWEPDDSTKDGQKGIFLGDDEWRETAWGASHHSMSQPIMVQRRSGQGFHGNSEVNAILSPRSESGGL
GVSMVEYVLSSSPADKLDSRFRKGNFGTRDAETDGPEKGDQKGKASPFEEDQNRDLKQGDDDDSKINGRGLPNGMDADCKDFNRTPGSRQ
ASPTEVVERLGPNTNPSEGLGPLPNPTANKPLVEEFSNPETQNLDAMEQVGLESLQFDYPGNQVPMDSSGATVGLFDYNSQQQLFQRTNA
LTVQQLTAAQQQQYALAAAQQPHIAGVFSAGLAPAAFVPNPYIISAAPPGTDPYTAAGLAAAATLAGPAVVPPQYYGVPWGVYPANLFQQ
QAAAAANNTASQQAASQAQPGQQQVLRAGAGQRPLTPNQGQQGQQAESLAAAAAANPTLAFGQGLATGMPGYQVLAPTAYYDQTGALVVG
PGARTGLGAPVRLMAPTPVLISSAAAQAAAAAAAGGTASSLTGSTNGLFRPIGTQPPQQQQQQPSTNLQSNSFYGSSSLTNSSQSSSLFS
HGPGQPGSTSLGFGSGNSLGAAIGSALSGFGSSVGSSASSSATRRESLSTSSDLYKRSSSSLAPIGQPFYNSLGFSSSPSPIGMPLPSQT
PGHSLTPPPSLSSHGSSSSLHLGGLTNGSGRYISAAPGAEAKYRSASSTSSLFSSSSQLFPPSRLRYNRSDIMPSGRSRLLEDFRNNRFP
NLQLRDLIGHIVEFSQDQHGSRFIQQKLERATPAERQMVFNEILQAAYQLMTDVFGNYVIQKFFEFGSLDQKLALATRIRGHVLPLALQM
YGCRVIQKALESISSDQQVISEMVKELDGHVLKCVKDQNGNHVVQKCIECVQPQSLQFIIDAFKGQVFVLSTHPYGCRVIQRILEHCTAE
QTLPILEELHQHTEQLVQDQYGNYVIQHVLEHGRPEDKSKIVSEIRGKVLALSQHKFASNVVEKCVTHASRAERALLIDEVCCQNDGPHS

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Fusion Gene PPI Analysis for LAPTM4A-PUM2

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Still interaction with
Tgene	PUM2	chr2:20251171	chr2:20527139	ENST00000403432		0	21	1_260	0	1065.0	SNAPIN

- Lost PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Tgene	PUM2	chr2:20251171	chr2:20527139	ENST00000319801		-1	19	1_260	17.0	988.0	SNAPIN
Tgene	PUM2	chr2:20251171	chr2:20527139	ENST00000338086		-1	20	1_260	17.0	1065.0	SNAPIN
Tgene	PUM2	chr2:20251171	chr2:20527139	ENST00000361078		-1	20	1_260	17.0	1067.0	SNAPIN

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for LAPTM4A-PUM2

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for LAPTM4A-PUM2

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source