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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:LARGE-OPA3 (FusionGDB2 ID:44107)

Fusion Gene Summary for LARGE-OPA3

check button Fusion gene summary
Fusion gene informationFusion gene name: LARGE-OPA3
Fusion gene ID: 44107
HgeneTgene
Gene symbol

LARGE

OPA3

Gene ID

9215

80207

Gene nameLARGE xylosyl- and glucuronyltransferase 1outer mitochondrial membrane lipid metabolism regulator OPA3
SynonymsLARGE|MDC1D|MDDGA6|MDDGB6MGA3
Cytomap

22q12.3

19q13.32

Type of geneprotein-codingprotein-coding
DescriptionLARGE xylosyl- and glucuronyltransferase 1acetylglucosaminyltransferase-like 1Aacetylglucosaminyltransferase-like proteinglycosyltransferase-like protein LARGE1optic atrophy 3 proteinOPA3 outer mitochondrial membrane lipid metabolism regulatorOptic atrophy 3 (Iraqi-Jewish 'optic atrophy plus')optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
Modification date2020032820200313
UniProtAcc

GYLTL1B,LARGE2

.
Ensembl transtripts involved in fusion geneENST00000337431, ENST00000354992, 
ENST00000397394, ENST00000402320, 
ENST00000437602, ENST00000452586, 
ENST00000421232, 		ENST00000544371, 
ENST00000263275, ENST00000323060, 
Fusion gene scores* DoF score10 X 9 X 6=54014 X 10 X 7=980
# samples 1316
** MAII scorelog2(13/540*10)=-2.05444778402238
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(16/980*10)=-2.61470984411521
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: LARGE [Title/Abstract] AND OPA3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointLARGE(33960833)-OPA3(46057169), # samples:1
LARGE(33960833)-OPA3(46032714), # samples:1
LARGE(33960834)-OPA3(46057169), # samples:1
LARGE(33960834)-OPA3(46032714), # samples:1
Anticipated loss of major functional domain due to fusion event.LARGE-OPA3 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneLARGE

GO:0035269

protein O-linked mannosylation

22223806|25138275|25279697|25279699


check buttonFusion gene breakpoints across LARGE (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across OPA3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-36-1574-01ALARGEchr22

33960834

-OPA3chr19

46032714

-
ChimerDB4OVTCGA-36-1574-01ALARGEchr22

33960834

-OPA3chr19

46057169

-
ChimerDB4OVTCGA-36-1574LARGEchr22

33960833

-OPA3chr19

46032714

-
ChimerDB4OVTCGA-36-1574LARGEchr22

33960833

-OPA3chr19

46057169

-


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Fusion Gene ORF analysis for LARGE-OPA3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000337431ENST00000544371LARGEchr22

33960834

-OPA3chr19

46057169

-
5CDS-5UTRENST00000337431ENST00000544371LARGEchr22

33960833

-OPA3chr19

46057169

-
5CDS-5UTRENST00000354992ENST00000544371LARGEchr22

33960834

-OPA3chr19

46057169

-
5CDS-5UTRENST00000354992ENST00000544371LARGEchr22

33960833

-OPA3chr19

46057169

-
5CDS-5UTRENST00000397394ENST00000544371LARGEchr22

33960834

-OPA3chr19

46057169

-
5CDS-5UTRENST00000397394ENST00000544371LARGEchr22

33960833

-OPA3chr19

46057169

-
5CDS-5UTRENST00000402320ENST00000544371LARGEchr22

33960834

-OPA3chr19

46057169

-
5CDS-5UTRENST00000402320ENST00000544371LARGEchr22

33960833

-OPA3chr19

46057169

-
5CDS-5UTRENST00000437602ENST00000544371LARGEchr22

33960834

-OPA3chr19

46057169

-
5CDS-5UTRENST00000437602ENST00000544371LARGEchr22

33960833

-OPA3chr19

46057169

-
5CDS-5UTRENST00000452586ENST00000544371LARGEchr22

33960834

-OPA3chr19

46057169

-
5CDS-5UTRENST00000452586ENST00000544371LARGEchr22

33960833

-OPA3chr19

46057169

-
5CDS-intronENST00000337431ENST00000263275LARGEchr22

33960834

-OPA3chr19

46032714

-
5CDS-intronENST00000337431ENST00000263275LARGEchr22

33960834

-OPA3chr19

46057169

-
5CDS-intronENST00000337431ENST00000263275LARGEchr22

33960833

-OPA3chr19

46032714

-
5CDS-intronENST00000337431ENST00000263275LARGEchr22

33960833

-OPA3chr19

46057169

-
5CDS-intronENST00000337431ENST00000323060LARGEchr22

33960834

-OPA3chr19

46057169

-
5CDS-intronENST00000337431ENST00000323060LARGEchr22

33960833

-OPA3chr19

46057169

-
5CDS-intronENST00000337431ENST00000544371LARGEchr22

33960834

-OPA3chr19

46032714

-
5CDS-intronENST00000337431ENST00000544371LARGEchr22

33960833

-OPA3chr19

46032714

-
5CDS-intronENST00000354992ENST00000263275LARGEchr22

33960834

-OPA3chr19

46032714

-
5CDS-intronENST00000354992ENST00000263275LARGEchr22

33960834

-OPA3chr19

46057169

-
5CDS-intronENST00000354992ENST00000263275LARGEchr22

33960833

-OPA3chr19

46032714

-
5CDS-intronENST00000354992ENST00000263275LARGEchr22

33960833

-OPA3chr19

46057169

-
5CDS-intronENST00000354992ENST00000323060LARGEchr22

33960834

-OPA3chr19

46057169

-
5CDS-intronENST00000354992ENST00000323060LARGEchr22

33960833

-OPA3chr19

46057169

-
5CDS-intronENST00000354992ENST00000544371LARGEchr22

33960834

-OPA3chr19

46032714

-
5CDS-intronENST00000354992ENST00000544371LARGEchr22

33960833

-OPA3chr19

46032714

-
5CDS-intronENST00000397394ENST00000263275LARGEchr22

33960834

-OPA3chr19

46032714

-
5CDS-intronENST00000397394ENST00000263275LARGEchr22

33960834

-OPA3chr19

46057169

-
5CDS-intronENST00000397394ENST00000263275LARGEchr22

33960833

-OPA3chr19

46032714

-
5CDS-intronENST00000397394ENST00000263275LARGEchr22

33960833

-OPA3chr19

46057169

-
5CDS-intronENST00000397394ENST00000323060LARGEchr22

33960834

-OPA3chr19

46057169

-
5CDS-intronENST00000397394ENST00000323060LARGEchr22

33960833

-OPA3chr19

46057169

-
5CDS-intronENST00000397394ENST00000544371LARGEchr22

33960834

-OPA3chr19

46032714

-
5CDS-intronENST00000397394ENST00000544371LARGEchr22

33960833

-OPA3chr19

46032714

-
5CDS-intronENST00000402320ENST00000263275LARGEchr22

33960834

-OPA3chr19

46032714

-
5CDS-intronENST00000402320ENST00000263275LARGEchr22

33960834

-OPA3chr19

46057169

-
5CDS-intronENST00000402320ENST00000263275LARGEchr22

33960833

-OPA3chr19

46032714

-
5CDS-intronENST00000402320ENST00000263275LARGEchr22

33960833

-OPA3chr19

46057169

-
5CDS-intronENST00000402320ENST00000323060LARGEchr22

33960834

-OPA3chr19

46057169

-
5CDS-intronENST00000402320ENST00000323060LARGEchr22

33960833

-OPA3chr19

46057169

-
5CDS-intronENST00000402320ENST00000544371LARGEchr22

33960834

-OPA3chr19

46032714

-
5CDS-intronENST00000402320ENST00000544371LARGEchr22

33960833

-OPA3chr19

46032714

-
5CDS-intronENST00000437602ENST00000263275LARGEchr22

33960834

-OPA3chr19

46032714

-
5CDS-intronENST00000437602ENST00000263275LARGEchr22

33960834

-OPA3chr19

46057169

-
5CDS-intronENST00000437602ENST00000263275LARGEchr22

33960833

-OPA3chr19

46032714

-
5CDS-intronENST00000437602ENST00000263275LARGEchr22

33960833

-OPA3chr19

46057169

-
5CDS-intronENST00000437602ENST00000323060LARGEchr22

33960834

-OPA3chr19

46057169

-
5CDS-intronENST00000437602ENST00000323060LARGEchr22

33960833

-OPA3chr19

46057169

-
5CDS-intronENST00000437602ENST00000544371LARGEchr22

33960834

-OPA3chr19

46032714

-
5CDS-intronENST00000437602ENST00000544371LARGEchr22

33960833

-OPA3chr19

46032714

-
5CDS-intronENST00000452586ENST00000263275LARGEchr22

33960834

-OPA3chr19

46032714

-
5CDS-intronENST00000452586ENST00000263275LARGEchr22

33960834

-OPA3chr19

46057169

-
5CDS-intronENST00000452586ENST00000263275LARGEchr22

33960833

-OPA3chr19

46032714

-
5CDS-intronENST00000452586ENST00000263275LARGEchr22

33960833

-OPA3chr19

46057169

-
5CDS-intronENST00000452586ENST00000323060LARGEchr22

33960834

-OPA3chr19

46057169

-
5CDS-intronENST00000452586ENST00000323060LARGEchr22

33960833

-OPA3chr19

46057169

-
5CDS-intronENST00000452586ENST00000544371LARGEchr22

33960834

-OPA3chr19

46032714

-
5CDS-intronENST00000452586ENST00000544371LARGEchr22

33960833

-OPA3chr19

46032714

-
Frame-shiftENST00000337431ENST00000323060LARGEchr22

33960834

-OPA3chr19

46032714

-
Frame-shiftENST00000337431ENST00000323060LARGEchr22

33960833

-OPA3chr19

46032714

-
Frame-shiftENST00000354992ENST00000323060LARGEchr22

33960834

-OPA3chr19

46032714

-
Frame-shiftENST00000354992ENST00000323060LARGEchr22

33960833

-OPA3chr19

46032714

-
Frame-shiftENST00000397394ENST00000323060LARGEchr22

33960834

-OPA3chr19

46032714

-
Frame-shiftENST00000397394ENST00000323060LARGEchr22

33960833

-OPA3chr19

46032714

-
Frame-shiftENST00000402320ENST00000323060LARGEchr22

33960834

-OPA3chr19

46032714

-
Frame-shiftENST00000402320ENST00000323060LARGEchr22

33960833

-OPA3chr19

46032714

-
Frame-shiftENST00000437602ENST00000323060LARGEchr22

33960834

-OPA3chr19

46032714

-
Frame-shiftENST00000437602ENST00000323060LARGEchr22

33960833

-OPA3chr19

46032714

-
In-frameENST00000452586ENST00000323060LARGEchr22

33960834

-OPA3chr19

46032714

-
In-frameENST00000452586ENST00000323060LARGEchr22

33960833

-OPA3chr19

46032714

-
intron-3CDSENST00000421232ENST00000323060LARGEchr22

33960834

-OPA3chr19

46032714

-
intron-3CDSENST00000421232ENST00000323060LARGEchr22

33960833

-OPA3chr19

46032714

-
intron-5UTRENST00000421232ENST00000544371LARGEchr22

33960834

-OPA3chr19

46057169

-
intron-5UTRENST00000421232ENST00000544371LARGEchr22

33960833

-OPA3chr19

46057169

-
intron-intronENST00000421232ENST00000263275LARGEchr22

33960834

-OPA3chr19

46032714

-
intron-intronENST00000421232ENST00000263275LARGEchr22

33960834

-OPA3chr19

46057169

-
intron-intronENST00000421232ENST00000263275LARGEchr22

33960833

-OPA3chr19

46032714

-
intron-intronENST00000421232ENST00000263275LARGEchr22

33960833

-OPA3chr19

46057169

-
intron-intronENST00000421232ENST00000323060LARGEchr22

33960834

-OPA3chr19

46057169

-
intron-intronENST00000421232ENST00000323060LARGEchr22

33960833

-OPA3chr19

46057169

-
intron-intronENST00000421232ENST00000544371LARGEchr22

33960834

-OPA3chr19

46032714

-
intron-intronENST00000421232ENST00000544371LARGEchr22

33960833

-OPA3chr19

46032714

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000452586LARGEchr2233960833-ENST00000323060OPA3chr1946032714-231128197681194
ENST00000452586LARGEchr2233960834-ENST00000323060OPA3chr1946032714-231128197681194

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000452586ENST00000323060LARGEchr2233960833-OPA3chr1946032714-0.0280012880.9719987
ENST00000452586ENST00000323060LARGEchr2233960834-OPA3chr1946032714-0.0280012880.9719987

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Fusion Genomic Features for LARGE-OPA3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for LARGE-OPA3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr22:33960833/chr19:46057169)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LARGE

GYLTL1B,LARGE2

.
721FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLARGEchr22:33960833chr19:46032714ENST00000337431-71553_95262705.0Coiled coilOntology_term=ECO:0000255
HgeneLARGEchr22:33960833chr19:46032714ENST00000354992-71653_95262757.0Coiled coilOntology_term=ECO:0000255
HgeneLARGEchr22:33960833chr19:46032714ENST00000397394-61553_95262757.0Coiled coilOntology_term=ECO:0000255
HgeneLARGEchr22:33960833chr19:46032714ENST00000402320-61453_95262705.0Coiled coilOntology_term=ECO:0000255
HgeneLARGEchr22:33960834chr19:46032714ENST00000337431-71553_95262705.0Coiled coilOntology_term=ECO:0000255
HgeneLARGEchr22:33960834chr19:46032714ENST00000354992-71653_95262757.0Coiled coilOntology_term=ECO:0000255
HgeneLARGEchr22:33960834chr19:46032714ENST00000397394-61553_95262757.0Coiled coilOntology_term=ECO:0000255
HgeneLARGEchr22:33960834chr19:46032714ENST00000402320-61453_95262705.0Coiled coilOntology_term=ECO:0000255
HgeneLARGEchr22:33960833chr19:46032714ENST00000337431-7151_10262705.0Topological domainCytoplasmic
HgeneLARGEchr22:33960833chr19:46032714ENST00000354992-7161_10262757.0Topological domainCytoplasmic
HgeneLARGEchr22:33960833chr19:46032714ENST00000397394-6151_10262757.0Topological domainCytoplasmic
HgeneLARGEchr22:33960833chr19:46032714ENST00000402320-6141_10262705.0Topological domainCytoplasmic
HgeneLARGEchr22:33960834chr19:46032714ENST00000337431-7151_10262705.0Topological domainCytoplasmic
HgeneLARGEchr22:33960834chr19:46032714ENST00000354992-7161_10262757.0Topological domainCytoplasmic
HgeneLARGEchr22:33960834chr19:46032714ENST00000397394-6151_10262757.0Topological domainCytoplasmic
HgeneLARGEchr22:33960834chr19:46032714ENST00000402320-6141_10262705.0Topological domainCytoplasmic
HgeneLARGEchr22:33960833chr19:46032714ENST00000337431-71511_31262705.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneLARGEchr22:33960833chr19:46032714ENST00000354992-71611_31262757.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneLARGEchr22:33960833chr19:46032714ENST00000397394-61511_31262757.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneLARGEchr22:33960833chr19:46032714ENST00000402320-61411_31262705.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneLARGEchr22:33960834chr19:46032714ENST00000337431-71511_31262705.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneLARGEchr22:33960834chr19:46032714ENST00000354992-71611_31262757.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneLARGEchr22:33960834chr19:46032714ENST00000397394-61511_31262757.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneLARGEchr22:33960834chr19:46032714ENST00000402320-61411_31262705.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneOPA3chr22:33960833chr19:46032714ENST0000026327502103_1630180.0Coiled coilOntology_term=ECO:0000255
TgeneOPA3chr22:33960833chr19:46032714ENST0000032306002103_16347181.0Coiled coilOntology_term=ECO:0000255
TgeneOPA3chr22:33960834chr19:46032714ENST0000026327502103_1630180.0Coiled coilOntology_term=ECO:0000255
TgeneOPA3chr22:33960834chr19:46032714ENST0000032306002103_16347181.0Coiled coilOntology_term=ECO:0000255

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLARGEchr22:33960833chr19:46032714ENST00000337431-715138_413262705.0RegionXylosyltransferase activity
HgeneLARGEchr22:33960833chr19:46032714ENST00000337431-715414_756262705.0RegionGlucuronyltransferase activity
HgeneLARGEchr22:33960833chr19:46032714ENST00000354992-716138_413262757.0RegionXylosyltransferase activity
HgeneLARGEchr22:33960833chr19:46032714ENST00000354992-716414_756262757.0RegionGlucuronyltransferase activity
HgeneLARGEchr22:33960833chr19:46032714ENST00000397394-615138_413262757.0RegionXylosyltransferase activity
HgeneLARGEchr22:33960833chr19:46032714ENST00000397394-615414_756262757.0RegionGlucuronyltransferase activity
HgeneLARGEchr22:33960833chr19:46032714ENST00000402320-614138_413262705.0RegionXylosyltransferase activity
HgeneLARGEchr22:33960833chr19:46032714ENST00000402320-614414_756262705.0RegionGlucuronyltransferase activity
HgeneLARGEchr22:33960834chr19:46032714ENST00000337431-715138_413262705.0RegionXylosyltransferase activity
HgeneLARGEchr22:33960834chr19:46032714ENST00000337431-715414_756262705.0RegionGlucuronyltransferase activity
HgeneLARGEchr22:33960834chr19:46032714ENST00000354992-716138_413262757.0RegionXylosyltransferase activity
HgeneLARGEchr22:33960834chr19:46032714ENST00000354992-716414_756262757.0RegionGlucuronyltransferase activity
HgeneLARGEchr22:33960834chr19:46032714ENST00000397394-615138_413262757.0RegionXylosyltransferase activity
HgeneLARGEchr22:33960834chr19:46032714ENST00000397394-615414_756262757.0RegionGlucuronyltransferase activity
HgeneLARGEchr22:33960834chr19:46032714ENST00000402320-614138_413262705.0RegionXylosyltransferase activity
HgeneLARGEchr22:33960834chr19:46032714ENST00000402320-614414_756262705.0RegionGlucuronyltransferase activity
HgeneLARGEchr22:33960833chr19:46032714ENST00000337431-71532_756262705.0Topological domainLumenal
HgeneLARGEchr22:33960833chr19:46032714ENST00000354992-71632_756262757.0Topological domainLumenal
HgeneLARGEchr22:33960833chr19:46032714ENST00000397394-61532_756262757.0Topological domainLumenal
HgeneLARGEchr22:33960833chr19:46032714ENST00000402320-61432_756262705.0Topological domainLumenal
HgeneLARGEchr22:33960834chr19:46032714ENST00000337431-71532_756262705.0Topological domainLumenal
HgeneLARGEchr22:33960834chr19:46032714ENST00000354992-71632_756262757.0Topological domainLumenal
HgeneLARGEchr22:33960834chr19:46032714ENST00000397394-61532_756262757.0Topological domainLumenal
HgeneLARGEchr22:33960834chr19:46032714ENST00000402320-61432_756262705.0Topological domainLumenal


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Fusion Gene Sequence for LARGE-OPA3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>44107_44107_1_LARGE-OPA3_LARGE_chr22_33960833_ENST00000452586_OPA3_chr19_46032714_ENST00000323060_length(transcript)=2311nt_BP=281nt
ATGAAAGGCAAATGACTTTTCAAACATTCTGCAGCTGGGATGACTTCTTTTTTTAATTTTTTAAAATATGTCAAGGTGATTTGTAATCCA
CAGCAAAATGTTAATATGGTCTGAAGTTTCCTGGATCCCCAATAAACATTACTCTGGGATTTATGGTCTGATGAAGCTTGTCCTGACCAA
GACTCTTCCTGCCAACCTGGAGAGAGTCATCGTCCTTGACACGGATATCACCTTTGCCACTGACATTGCAGAGCTGTGGGCTGTGTTCCA
CAAGTTCAAAGTGTACCACTGGCTGGAGATGCGGACCAAAATGCGCATCATGGGTTTCAATGCCGCTGCCATCAAGCCGCTGAACGAGGG
TGCAGCCGCCGAGCTGGGCGCGGAGCTGCTGGGCGAGGGCATCATCTTCATCACCGCCTGCAGCTGCCTGATGCTGGAGTATTGGCGCCA
CCAGTTGCAGCAGCGCCGCAAGGAAAAGGAGCGACGTGTTGCCAGGGAGGCGCTGCGGGGCGAGGTGGGCCACTTGGGGCTGGCGCTCGA
GGAGTTGCAGGCGCAGGTGCAGGCGACGTCGACGCAGCTCGCCCTGGAGGAGCTGCGCGCTCAGCTGCAGGAGGTGCGAGCCCACCTCTG
CCTCCGAGACCCGCCGCCTGCACCCCCAGTTGCGCCGGCGTCCGAGAAATAGGAGGTCTCGGGGCCCTGGTCTTGGAGGTGACTGCTGTC
TGGACTGCGAAGTCTCTGTCTTGGCCTATTCTCCGCACTGTCCCATCCTGGACCGGCCCAGCTGACACCACCCAGTCCTTCGGGGGCGCC
GGAGAGATCCTGGGCTGGAGCTGATCGAACCTCCCTACTAACCTGCCCAGTGGTACCTTCCACTGGGACTCTCCGCCTCCTGCAGGTGGA
ACGTTCCAAGAAGGACCCCGCCCTATCCCACCCCGCCCCTGCCAGCGCATTTGTTGAGCACTTTGGAAAGACAGCGTCTTTTATCAGACC
CCACCTCCCTACCGCTAGGTAGGCCAGCAGGACGTCCACCTCTTTTGGCAAAACAAAATTCTGCACCCGGATTTAGCCACCTCTCATTCT
GTCACCCGCACCCTCACTCACCTGAGTGGACCCTTCCCCTAGGACGCTCATCCTTTGCACCGAACACCACCTACCTCCTCCTCATTGGTA
CAGACCATTGTAAAGATGCACAAAGTTCCTACGGACTTCCCGACCCGCCCCCTTCCATCTACCTCAGTCTTAGGGGGAAAGGTGGGGGTG
AATCCTGGACTGCGTTAGCTCCAATGAGTCACCACCCTGCGGCTCCTGACCTTAATCCATCTTAGTACCTGTCATTGACATCCTCCCCTC
CCTGAGTGGATCGATCCAACATAACCCCCCTCTTCTTCCACCTATGGCGCACCCCACTGGCATGGCTATGCTGGGTCTTCCAGGGAAACG
CCTCCCAGCCCGGCATTCTGTGGTCTGTTCCAGCAGGACGTGGCCTTTTGGGAGGAAAAACCGGTCTTGACCAGGGCTAGTCCATTCTGG
CTTTCAGGCTCAGTCACTTGGTCACCAGTCCCCAGTCCTGGACCTACTGCTACTGTCCTTTTATCCGGTCCTCCCTCGCTGTCCTCTTCA
GTTGCCTTTGCTAGGGACCGGCCTGTCCCTTTACTACCTAAGTCATCGTCAGTTCGCCCAACTTCCCTCCAAATCTGCCCCTCACGGTAC
GCAGGGATCGCCCTTCCTTCCTGCCTTTGGACTGGTCCAGGTCCTCCTCCGCCCTCCTTCACGCAAAGGCCTCCTCCAGGGGGACTACCT
GTCCCTCAGCCCAGAGGTCCCCCTGTCCAAGCGGGGTATTCCACCAGGCCATATGACCTACCCACCCGACAACTGAAGGGGGCGTGGATG
AGCTCTGTGACTCTGAATGCTACTTTATAAATCGACTGTCAGCGTTTTCTAATTAAAGGAGCTCTGGGGTAAAGATCTTAAGAACGTGTC
TGAGAACCATAATGTGCGTCTGCAAAATGTCATTGAAATTAGGAAAGAAGGCCGGACACAGTGGCTCACGCCTGTAATTCCAGCACTTTA
AGAGGCCAAAGCAGGAGGACTGCTGGAGGCCAGGAGTTAGAGACCAACCTAGGCAACACAGCAAGACCGCATCTCTACGAAAAATGAAAA
TATTAGCTAGGCGTCATACCAAACGCCTGTAGTTCCAGCTACTTGGGAGGCTGAGGCAGGAGGATCCCTTGAGCCCAGGAGTTCAAGGCT

>44107_44107_1_LARGE-OPA3_LARGE_chr22_33960833_ENST00000452586_OPA3_chr19_46032714_ENST00000323060_length(amino acids)=194AA_BP=61
MLIWSEVSWIPNKHYSGIYGLMKLVLTKTLPANLERVIVLDTDITFATDIAELWAVFHKFKVYHWLEMRTKMRIMGFNAAAIKPLNEGAA
AELGAELLGEGIIFITACSCLMLEYWRHQLQQRRKEKERRVAREALRGEVGHLGLALEELQAQVQATSTQLALEELRAQLQEVRAHLCLR

--------------------------------------------------------------
>44107_44107_2_LARGE-OPA3_LARGE_chr22_33960834_ENST00000452586_OPA3_chr19_46032714_ENST00000323060_length(transcript)=2311nt_BP=281nt
ATGAAAGGCAAATGACTTTTCAAACATTCTGCAGCTGGGATGACTTCTTTTTTTAATTTTTTAAAATATGTCAAGGTGATTTGTAATCCA
CAGCAAAATGTTAATATGGTCTGAAGTTTCCTGGATCCCCAATAAACATTACTCTGGGATTTATGGTCTGATGAAGCTTGTCCTGACCAA
GACTCTTCCTGCCAACCTGGAGAGAGTCATCGTCCTTGACACGGATATCACCTTTGCCACTGACATTGCAGAGCTGTGGGCTGTGTTCCA
CAAGTTCAAAGTGTACCACTGGCTGGAGATGCGGACCAAAATGCGCATCATGGGTTTCAATGCCGCTGCCATCAAGCCGCTGAACGAGGG
TGCAGCCGCCGAGCTGGGCGCGGAGCTGCTGGGCGAGGGCATCATCTTCATCACCGCCTGCAGCTGCCTGATGCTGGAGTATTGGCGCCA
CCAGTTGCAGCAGCGCCGCAAGGAAAAGGAGCGACGTGTTGCCAGGGAGGCGCTGCGGGGCGAGGTGGGCCACTTGGGGCTGGCGCTCGA
GGAGTTGCAGGCGCAGGTGCAGGCGACGTCGACGCAGCTCGCCCTGGAGGAGCTGCGCGCTCAGCTGCAGGAGGTGCGAGCCCACCTCTG
CCTCCGAGACCCGCCGCCTGCACCCCCAGTTGCGCCGGCGTCCGAGAAATAGGAGGTCTCGGGGCCCTGGTCTTGGAGGTGACTGCTGTC
TGGACTGCGAAGTCTCTGTCTTGGCCTATTCTCCGCACTGTCCCATCCTGGACCGGCCCAGCTGACACCACCCAGTCCTTCGGGGGCGCC
GGAGAGATCCTGGGCTGGAGCTGATCGAACCTCCCTACTAACCTGCCCAGTGGTACCTTCCACTGGGACTCTCCGCCTCCTGCAGGTGGA
ACGTTCCAAGAAGGACCCCGCCCTATCCCACCCCGCCCCTGCCAGCGCATTTGTTGAGCACTTTGGAAAGACAGCGTCTTTTATCAGACC
CCACCTCCCTACCGCTAGGTAGGCCAGCAGGACGTCCACCTCTTTTGGCAAAACAAAATTCTGCACCCGGATTTAGCCACCTCTCATTCT
GTCACCCGCACCCTCACTCACCTGAGTGGACCCTTCCCCTAGGACGCTCATCCTTTGCACCGAACACCACCTACCTCCTCCTCATTGGTA
CAGACCATTGTAAAGATGCACAAAGTTCCTACGGACTTCCCGACCCGCCCCCTTCCATCTACCTCAGTCTTAGGGGGAAAGGTGGGGGTG
AATCCTGGACTGCGTTAGCTCCAATGAGTCACCACCCTGCGGCTCCTGACCTTAATCCATCTTAGTACCTGTCATTGACATCCTCCCCTC
CCTGAGTGGATCGATCCAACATAACCCCCCTCTTCTTCCACCTATGGCGCACCCCACTGGCATGGCTATGCTGGGTCTTCCAGGGAAACG
CCTCCCAGCCCGGCATTCTGTGGTCTGTTCCAGCAGGACGTGGCCTTTTGGGAGGAAAAACCGGTCTTGACCAGGGCTAGTCCATTCTGG
CTTTCAGGCTCAGTCACTTGGTCACCAGTCCCCAGTCCTGGACCTACTGCTACTGTCCTTTTATCCGGTCCTCCCTCGCTGTCCTCTTCA
GTTGCCTTTGCTAGGGACCGGCCTGTCCCTTTACTACCTAAGTCATCGTCAGTTCGCCCAACTTCCCTCCAAATCTGCCCCTCACGGTAC
GCAGGGATCGCCCTTCCTTCCTGCCTTTGGACTGGTCCAGGTCCTCCTCCGCCCTCCTTCACGCAAAGGCCTCCTCCAGGGGGACTACCT
GTCCCTCAGCCCAGAGGTCCCCCTGTCCAAGCGGGGTATTCCACCAGGCCATATGACCTACCCACCCGACAACTGAAGGGGGCGTGGATG
AGCTCTGTGACTCTGAATGCTACTTTATAAATCGACTGTCAGCGTTTTCTAATTAAAGGAGCTCTGGGGTAAAGATCTTAAGAACGTGTC
TGAGAACCATAATGTGCGTCTGCAAAATGTCATTGAAATTAGGAAAGAAGGCCGGACACAGTGGCTCACGCCTGTAATTCCAGCACTTTA
AGAGGCCAAAGCAGGAGGACTGCTGGAGGCCAGGAGTTAGAGACCAACCTAGGCAACACAGCAAGACCGCATCTCTACGAAAAATGAAAA
TATTAGCTAGGCGTCATACCAAACGCCTGTAGTTCCAGCTACTTGGGAGGCTGAGGCAGGAGGATCCCTTGAGCCCAGGAGTTCAAGGCT

>44107_44107_2_LARGE-OPA3_LARGE_chr22_33960834_ENST00000452586_OPA3_chr19_46032714_ENST00000323060_length(amino acids)=194AA_BP=61
MLIWSEVSWIPNKHYSGIYGLMKLVLTKTLPANLERVIVLDTDITFATDIAELWAVFHKFKVYHWLEMRTKMRIMGFNAAAIKPLNEGAA
AELGAELLGEGIIFITACSCLMLEYWRHQLQQRRKEKERRVAREALRGEVGHLGLALEELQAQVQATSTQLALEELRAQLQEVRAHLCLR

--------------------------------------------------------------

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Fusion Gene PPI Analysis for LARGE-OPA3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for LARGE-OPA3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for LARGE-OPA3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource