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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:LARP4-HPD (FusionGDB2 ID:44149)

Fusion Gene Summary for LARP4-HPD

check button Fusion gene summary
Fusion gene informationFusion gene name: LARP4-HPD
Fusion gene ID: 44149
HgeneTgene
Gene symbol

LARP4

HPD

Gene ID

113251

3242

Gene nameLa ribonucleoprotein 44-hydroxyphenylpyruvate dioxygenase
SynonymsPP132964-HPPD|4HPPD|GLOD3|HPPDASE|PPD
Cytomap

12q13.12

12q24.31

Type of geneprotein-codingprotein-coding
Descriptionla-related protein 4La ribonucleoprotein domain family member 4c-Mpl binding protein4-hydroxyphenylpyruvate dioxygenase4-hydroxyphenylpyruvic acid oxidaseglyoxalase domain containing 3
Modification date2020031320200313
UniProtAcc

Q71RC2

P32754

Ensembl transtripts involved in fusion geneENST00000293618, ENST00000347328, 
ENST00000398473, ENST00000429001, 
ENST00000518444, ENST00000518561, 
ENST00000522085, 		ENST00000543869, 
ENST00000289004, ENST00000543163, 
Fusion gene scores* DoF score15 X 8 X 11=13204 X 4 X 3=48
# samples 184
** MAII scorelog2(18/1320*10)=-2.87446911791614
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: LARP4 [Title/Abstract] AND HPD [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointLARP4(50824353)-HPD(122285120), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across LARP4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across HPD (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-YL-A8HO-01ALARP4chr12

50824353

-HPDchr12

122285120

-
ChimerDB4PRADTCGA-YL-A8HO-01ALARP4chr12

50824353

+HPDchr12

122285120

-
ChimerDB4PRADTCGA-YL-A8HOLARP4chr12

50824353

+HPDchr12

122285120

-


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Fusion Gene ORF analysis for LARP4-HPD

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000293618ENST00000543869LARP4chr12

50824353

+HPDchr12

122285120

-
5CDS-5UTRENST00000347328ENST00000543869LARP4chr12

50824353

+HPDchr12

122285120

-
5CDS-5UTRENST00000398473ENST00000543869LARP4chr12

50824353

+HPDchr12

122285120

-
5CDS-5UTRENST00000429001ENST00000543869LARP4chr12

50824353

+HPDchr12

122285120

-
5CDS-5UTRENST00000518444ENST00000543869LARP4chr12

50824353

+HPDchr12

122285120

-
5CDS-5UTRENST00000518561ENST00000543869LARP4chr12

50824353

+HPDchr12

122285120

-
5CDS-5UTRENST00000522085ENST00000543869LARP4chr12

50824353

+HPDchr12

122285120

-
In-frameENST00000293618ENST00000289004LARP4chr12

50824353

+HPDchr12

122285120

-
In-frameENST00000293618ENST00000543163LARP4chr12

50824353

+HPDchr12

122285120

-
In-frameENST00000347328ENST00000289004LARP4chr12

50824353

+HPDchr12

122285120

-
In-frameENST00000347328ENST00000543163LARP4chr12

50824353

+HPDchr12

122285120

-
In-frameENST00000398473ENST00000289004LARP4chr12

50824353

+HPDchr12

122285120

-
In-frameENST00000398473ENST00000543163LARP4chr12

50824353

+HPDchr12

122285120

-
In-frameENST00000429001ENST00000289004LARP4chr12

50824353

+HPDchr12

122285120

-
In-frameENST00000429001ENST00000543163LARP4chr12

50824353

+HPDchr12

122285120

-
In-frameENST00000518444ENST00000289004LARP4chr12

50824353

+HPDchr12

122285120

-
In-frameENST00000518444ENST00000543163LARP4chr12

50824353

+HPDchr12

122285120

-
In-frameENST00000518561ENST00000289004LARP4chr12

50824353

+HPDchr12

122285120

-
In-frameENST00000518561ENST00000543163LARP4chr12

50824353

+HPDchr12

122285120

-
In-frameENST00000522085ENST00000289004LARP4chr12

50824353

+HPDchr12

122285120

-
In-frameENST00000522085ENST00000543163LARP4chr12

50824353

+HPDchr12

122285120

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000293618LARP4chr1250824353+ENST00000289004HPDchr12122285120-13876002021185327
ENST00000293618LARP4chr1250824353+ENST00000543163HPDchr12122285120-13846002021185327
ENST00000429001LARP4chr1250824353+ENST00000289004HPDchr12122285120-13575701541155333
ENST00000429001LARP4chr1250824353+ENST00000543163HPDchr12122285120-13545701541155333
ENST00000398473LARP4chr1250824353+ENST00000289004HPDchr12122285120-12975101121095327
ENST00000398473LARP4chr1250824353+ENST00000543163HPDchr12122285120-12945101121095327
ENST00000518444LARP4chr1250824353+ENST00000289004HPDchr12122285120-1264477821062326
ENST00000518444LARP4chr1250824353+ENST00000543163HPDchr12122285120-1261477821062326
ENST00000347328LARP4chr1250824353+ENST00000289004HPDchr12122285120-1211424261009327
ENST00000347328LARP4chr1250824353+ENST00000543163HPDchr12122285120-1208424261009327
ENST00000522085LARP4chr1250824353+ENST00000289004HPDchr12122285120-12885011031086327
ENST00000522085LARP4chr1250824353+ENST00000543163HPDchr12122285120-12855011031086327
ENST00000518561LARP4chr1250824353+ENST00000289004HPDchr12122285120-12895023141087257
ENST00000518561LARP4chr1250824353+ENST00000543163HPDchr12122285120-12865023141087257

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000293618ENST00000289004LARP4chr1250824353+HPDchr12122285120-0.0028427070.99715734
ENST00000293618ENST00000543163LARP4chr1250824353+HPDchr12122285120-0.0028453180.9971547
ENST00000429001ENST00000289004LARP4chr1250824353+HPDchr12122285120-0.0030356640.9969643
ENST00000429001ENST00000543163LARP4chr1250824353+HPDchr12122285120-0.0030681360.9969318
ENST00000398473ENST00000289004LARP4chr1250824353+HPDchr12122285120-0.0030022240.99699783
ENST00000398473ENST00000543163LARP4chr1250824353+HPDchr12122285120-0.0030309990.99696904
ENST00000518444ENST00000289004LARP4chr1250824353+HPDchr12122285120-0.0020856820.99791425
ENST00000518444ENST00000543163LARP4chr1250824353+HPDchr12122285120-0.0020908610.9979091
ENST00000347328ENST00000289004LARP4chr1250824353+HPDchr12122285120-0.0031512490.99684876
ENST00000347328ENST00000543163LARP4chr1250824353+HPDchr12122285120-0.0032006560.99679935
ENST00000522085ENST00000289004LARP4chr1250824353+HPDchr12122285120-0.0030554990.9969445
ENST00000522085ENST00000543163LARP4chr1250824353+HPDchr12122285120-0.0030807540.9969193
ENST00000518561ENST00000289004LARP4chr1250824353+HPDchr12122285120-0.0031556870.9968443
ENST00000518561ENST00000543163LARP4chr1250824353+HPDchr12122285120-0.0032051130.9967949

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Fusion Genomic Features for LARP4-HPD


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for LARP4-HPD


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:50824353/chr12:122285120)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LARP4

Q71RC2

HPD

P32754

FUNCTION: RNA binding protein that binds to the poly-A tract of mRNA molecules (PubMed:21098120). Associates with the 40S ribosomal subunit and with polysomes (PubMed:21098120). Plays a role in the regulation of mRNA translation (PubMed:21098120). Plays a role in the regulation of cell morphology and cytoskeletal organization (PubMed:21834987, PubMed:27615744). {ECO:0000269|PubMed:21098120, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:27615744}.FUNCTION: Key enzyme in the degradation of tyrosine.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneHPDchr12:50824353chr12:122285120ENST00000543163915180_338159355.0DomainVOC 2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLARP4chr12:50824353chr12:122285120ENST00000293618+415113_202132654.0DomainHTH La-type RNA-binding
HgeneLARP4chr12:50824353chr12:122285120ENST00000293618+415203_281132654.0DomainNote=RRM
HgeneLARP4chr12:50824353chr12:122285120ENST00000347328+415113_202132654.0DomainHTH La-type RNA-binding
HgeneLARP4chr12:50824353chr12:122285120ENST00000347328+415203_281132654.0DomainNote=RRM
HgeneLARP4chr12:50824353chr12:122285120ENST00000398473+416113_202132725.0DomainHTH La-type RNA-binding
HgeneLARP4chr12:50824353chr12:122285120ENST00000398473+416203_281132725.0DomainNote=RRM
HgeneLARP4chr12:50824353chr12:122285120ENST00000429001+416113_202138731.0DomainHTH La-type RNA-binding
HgeneLARP4chr12:50824353chr12:122285120ENST00000429001+416203_281138731.0DomainNote=RRM
HgeneLARP4chr12:50824353chr12:122285120ENST00000518444+416113_202131724.0DomainHTH La-type RNA-binding
HgeneLARP4chr12:50824353chr12:122285120ENST00000518444+416203_281131724.0DomainNote=RRM
HgeneLARP4chr12:50824353chr12:122285120ENST00000522085+411113_202132446.0DomainHTH La-type RNA-binding
HgeneLARP4chr12:50824353chr12:122285120ENST00000522085+411203_281132446.0DomainNote=RRM
TgeneHPDchr12:50824353chr12:122285120ENST0000054316391518_149159355.0DomainVOC 1


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Fusion Gene Sequence for LARP4-HPD


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>44149_44149_1_LARP4-HPD_LARP4_chr12_50824353_ENST00000293618_HPD_chr12_122285120_ENST00000289004_length(transcript)=1387nt_BP=600nt
AGACCCGGAAGCAGTTGTTGTTTCAAGGGAGGTGGGACTGGGCGGGTCAGGCCGCAGCGGCTGACGGCAGGGGAGGAGCCGGGTCCACTG
CCGGGTGGAGGGGCAAGGCGAGTGTGTGTCCTTATCCTAGCAATTGGGGCGCGGGCCTGTGAGCCAGTTGGAGTTGCGGCGGCGGGAACG
ATTGGGCTGAGCAGAGGACGACATGTTGCTTTTCGTGGAGCAGGTAGCATCTAAAGGAACTGGTTTAAATCCTAATGCCAAAGTATGGCA
AGAAATTGCTCCTGGAAATACTGATGCCACCCCAGTAACTCATGGAACTGAAAGCTCTTGGCATGAAATAGCAGCTACATCAGGTGCTCA
TCCTGAGGGTAATGCAGAGCTCTCAGAAGATATATGTAAAGAATATGAAGTAATGTATTCTTCATCTTGTGAAACCACAAGAAATACTAC
AGGCATTGAAGAATCAACTGATGGGATGATTTTAGGACCAGAAGATCTGAGTTACCAAATATATGATGTTTCCGGAGAAAGCAATTCAGC
AGTTTCTACAGAAGACCTAAAAGAATGTCTGAAGAAACAATTAGAATTCTGTTTTTCACGGTACCTGAAAAACCTGCAGTTCCACCGCTT
CTGGTCCGTGGATGACACGCAGGTGCACACGGAATATAGCTCTCTGCGATCCATTGTGGTGGCCAACTATGAAGAGTCCATCAAGATGCC
CATCAATGAGCCAGCGCCTGGCAAGAAGAAGTCCCAGATCCAGGAATATGTGGACTATAACGGGGGCGCTGGGGTCCAGCACATCGCTCT
CAAGACCGAAGACATCATCACAGCGATTCGCCACTTGAGAGAGAGAGGCCTGGAGTTCTTATCTGTTCCCTCCACGTACTACAAACAACT
GCGGGAGAAGCTGAAGACGGCCAAGATCAAGGTGAAGGAGAACATTGATGCCCTGGAGGAGCTGAAAATCCTGGTGGACTACGACGAGAA
AGGCTACCTCCTGCAGATCTTCACCAAACCGGTGCAGGACCGGCCCACGCTCTTCCTGGAAGTCATCCAGCGCCACAACCACCAGGGTTT
TGGAGCCGGCAACTTCAACTCACTGTTCAAGGCTTTCGAGGAGGAGCAGAACCTGCGGGGTAACCTCACCAACATGGAGACCAATGGGGT
GGTGCCCGGCATGTAAGCCCCGCCCACCCCACGGAGGCCACAGCCACACAGCCACGCCCCCTGATTCTGGAACTCGCCCAACTTCCCTAC
TGGCTGCTCCCCTTGGGTCCCGCCCACCAGCGGACTCGGCCCCCAAGGCTCCGCCCACACTGACCACGCCCCTCGGCGGGGCCGCCCTCT

>44149_44149_1_LARP4-HPD_LARP4_chr12_50824353_ENST00000293618_HPD_chr12_122285120_ENST00000289004_length(amino acids)=327AA_BP=132
MLLFVEQVASKGTGLNPNAKVWQEIAPGNTDATPVTHGTESSWHEIAATSGAHPEGNAELSEDICKEYEVMYSSSCETTRNTTGIEESTD
GMILGPEDLSYQIYDVSGESNSAVSTEDLKECLKKQLEFCFSRYLKNLQFHRFWSVDDTQVHTEYSSLRSIVVANYEESIKMPINEPAPG
KKKSQIQEYVDYNGGAGVQHIALKTEDIITAIRHLRERGLEFLSVPSTYYKQLREKLKTAKIKVKENIDALEELKILVDYDEKGYLLQIF

--------------------------------------------------------------
>44149_44149_2_LARP4-HPD_LARP4_chr12_50824353_ENST00000293618_HPD_chr12_122285120_ENST00000543163_length(transcript)=1384nt_BP=600nt
AGACCCGGAAGCAGTTGTTGTTTCAAGGGAGGTGGGACTGGGCGGGTCAGGCCGCAGCGGCTGACGGCAGGGGAGGAGCCGGGTCCACTG
CCGGGTGGAGGGGCAAGGCGAGTGTGTGTCCTTATCCTAGCAATTGGGGCGCGGGCCTGTGAGCCAGTTGGAGTTGCGGCGGCGGGAACG
ATTGGGCTGAGCAGAGGACGACATGTTGCTTTTCGTGGAGCAGGTAGCATCTAAAGGAACTGGTTTAAATCCTAATGCCAAAGTATGGCA
AGAAATTGCTCCTGGAAATACTGATGCCACCCCAGTAACTCATGGAACTGAAAGCTCTTGGCATGAAATAGCAGCTACATCAGGTGCTCA
TCCTGAGGGTAATGCAGAGCTCTCAGAAGATATATGTAAAGAATATGAAGTAATGTATTCTTCATCTTGTGAAACCACAAGAAATACTAC
AGGCATTGAAGAATCAACTGATGGGATGATTTTAGGACCAGAAGATCTGAGTTACCAAATATATGATGTTTCCGGAGAAAGCAATTCAGC
AGTTTCTACAGAAGACCTAAAAGAATGTCTGAAGAAACAATTAGAATTCTGTTTTTCACGGTACCTGAAAAACCTGCAGTTCCACCGCTT
CTGGTCCGTGGATGACACGCAGGTGCACACGGAATATAGCTCTCTGCGATCCATTGTGGTGGCCAACTATGAAGAGTCCATCAAGATGCC
CATCAATGAGCCAGCGCCTGGCAAGAAGAAGTCCCAGATCCAGGAATATGTGGACTATAACGGGGGCGCTGGGGTCCAGCACATCGCTCT
CAAGACCGAAGACATCATCACAGCGATTCGCCACTTGAGAGAGAGAGGCCTGGAGTTCTTATCTGTTCCCTCCACGTACTACAAACAACT
GCGGGAGAAGCTGAAGACGGCCAAGATCAAGGTGAAGGAGAACATTGATGCCCTGGAGGAGCTGAAAATCCTGGTGGACTACGACGAGAA
AGGCTACCTCCTGCAGATCTTCACCAAACCGGTGCAGGACCGGCCCACGCTCTTCCTGGAAGTCATCCAGCGCCACAACCACCAGGGTTT
TGGAGCCGGCAACTTCAACTCACTGTTCAAGGCTTTCGAGGAGGAGCAGAACCTGCGGGGTAACCTCACCAACATGGAGACCAATGGGGT
GGTGCCCGGCATGTAAGCCCCGCCCACCCCACGGAGGCCACAGCCACACAGCCACGCCCCCTGATTCTGGAACTCGCCCAACTTCCCTAC
TGGCTGCTCCCCTTGGGTCCCGCCCACCAGCGGACTCGGCCCCCAAGGCTCCGCCCACACTGACCACGCCCCTCGGCGGGGCCGCCCTCT

>44149_44149_2_LARP4-HPD_LARP4_chr12_50824353_ENST00000293618_HPD_chr12_122285120_ENST00000543163_length(amino acids)=327AA_BP=132
MLLFVEQVASKGTGLNPNAKVWQEIAPGNTDATPVTHGTESSWHEIAATSGAHPEGNAELSEDICKEYEVMYSSSCETTRNTTGIEESTD
GMILGPEDLSYQIYDVSGESNSAVSTEDLKECLKKQLEFCFSRYLKNLQFHRFWSVDDTQVHTEYSSLRSIVVANYEESIKMPINEPAPG
KKKSQIQEYVDYNGGAGVQHIALKTEDIITAIRHLRERGLEFLSVPSTYYKQLREKLKTAKIKVKENIDALEELKILVDYDEKGYLLQIF

--------------------------------------------------------------
>44149_44149_3_LARP4-HPD_LARP4_chr12_50824353_ENST00000347328_HPD_chr12_122285120_ENST00000289004_length(transcript)=1211nt_BP=424nt
AACGATTGGGCTGAGCAGAGGACGACATGTTGCTTTTCGTGGAGCAGGTAGCATCTAAAGGAACTGGTTTAAATCCTAATGCCAAAGTAT
GGCAAGAAATTGCTCCTGGAAATACTGATGCCACCCCAGTAACTCATGGAACTGAAAGCTCTTGGCATGAAATAGCAGCTACATCAGGTG
CTCATCCTGAGGGTAATGCAGAGCTCTCAGAAGATATATGTAAAGAATATGAAGTAATGTATTCTTCATCTTGTGAAACCACAAGAAATA
CTACAGGCATTGAAGAATCAACTGATGGGATGATTTTAGGACCAGAAGATCTGAGTTACCAAATATATGATGTTTCCGGAGAAAGCAATT
CAGCAGTTTCTACAGAAGACCTAAAAGAATGTCTGAAGAAACAATTAGAATTCTGTTTTTCACGGTACCTGAAAAACCTGCAGTTCCACC
GCTTCTGGTCCGTGGATGACACGCAGGTGCACACGGAATATAGCTCTCTGCGATCCATTGTGGTGGCCAACTATGAAGAGTCCATCAAGA
TGCCCATCAATGAGCCAGCGCCTGGCAAGAAGAAGTCCCAGATCCAGGAATATGTGGACTATAACGGGGGCGCTGGGGTCCAGCACATCG
CTCTCAAGACCGAAGACATCATCACAGCGATTCGCCACTTGAGAGAGAGAGGCCTGGAGTTCTTATCTGTTCCCTCCACGTACTACAAAC
AACTGCGGGAGAAGCTGAAGACGGCCAAGATCAAGGTGAAGGAGAACATTGATGCCCTGGAGGAGCTGAAAATCCTGGTGGACTACGACG
AGAAAGGCTACCTCCTGCAGATCTTCACCAAACCGGTGCAGGACCGGCCCACGCTCTTCCTGGAAGTCATCCAGCGCCACAACCACCAGG
GTTTTGGAGCCGGCAACTTCAACTCACTGTTCAAGGCTTTCGAGGAGGAGCAGAACCTGCGGGGTAACCTCACCAACATGGAGACCAATG
GGGTGGTGCCCGGCATGTAAGCCCCGCCCACCCCACGGAGGCCACAGCCACACAGCCACGCCCCCTGATTCTGGAACTCGCCCAACTTCC
CTACTGGCTGCTCCCCTTGGGTCCCGCCCACCAGCGGACTCGGCCCCCAAGGCTCCGCCCACACTGACCACGCCCCTCGGCGGGGCCGCC

>44149_44149_3_LARP4-HPD_LARP4_chr12_50824353_ENST00000347328_HPD_chr12_122285120_ENST00000289004_length(amino acids)=327AA_BP=132
MLLFVEQVASKGTGLNPNAKVWQEIAPGNTDATPVTHGTESSWHEIAATSGAHPEGNAELSEDICKEYEVMYSSSCETTRNTTGIEESTD
GMILGPEDLSYQIYDVSGESNSAVSTEDLKECLKKQLEFCFSRYLKNLQFHRFWSVDDTQVHTEYSSLRSIVVANYEESIKMPINEPAPG
KKKSQIQEYVDYNGGAGVQHIALKTEDIITAIRHLRERGLEFLSVPSTYYKQLREKLKTAKIKVKENIDALEELKILVDYDEKGYLLQIF

--------------------------------------------------------------
>44149_44149_4_LARP4-HPD_LARP4_chr12_50824353_ENST00000347328_HPD_chr12_122285120_ENST00000543163_length(transcript)=1208nt_BP=424nt
AACGATTGGGCTGAGCAGAGGACGACATGTTGCTTTTCGTGGAGCAGGTAGCATCTAAAGGAACTGGTTTAAATCCTAATGCCAAAGTAT
GGCAAGAAATTGCTCCTGGAAATACTGATGCCACCCCAGTAACTCATGGAACTGAAAGCTCTTGGCATGAAATAGCAGCTACATCAGGTG
CTCATCCTGAGGGTAATGCAGAGCTCTCAGAAGATATATGTAAAGAATATGAAGTAATGTATTCTTCATCTTGTGAAACCACAAGAAATA
CTACAGGCATTGAAGAATCAACTGATGGGATGATTTTAGGACCAGAAGATCTGAGTTACCAAATATATGATGTTTCCGGAGAAAGCAATT
CAGCAGTTTCTACAGAAGACCTAAAAGAATGTCTGAAGAAACAATTAGAATTCTGTTTTTCACGGTACCTGAAAAACCTGCAGTTCCACC
GCTTCTGGTCCGTGGATGACACGCAGGTGCACACGGAATATAGCTCTCTGCGATCCATTGTGGTGGCCAACTATGAAGAGTCCATCAAGA
TGCCCATCAATGAGCCAGCGCCTGGCAAGAAGAAGTCCCAGATCCAGGAATATGTGGACTATAACGGGGGCGCTGGGGTCCAGCACATCG
CTCTCAAGACCGAAGACATCATCACAGCGATTCGCCACTTGAGAGAGAGAGGCCTGGAGTTCTTATCTGTTCCCTCCACGTACTACAAAC
AACTGCGGGAGAAGCTGAAGACGGCCAAGATCAAGGTGAAGGAGAACATTGATGCCCTGGAGGAGCTGAAAATCCTGGTGGACTACGACG
AGAAAGGCTACCTCCTGCAGATCTTCACCAAACCGGTGCAGGACCGGCCCACGCTCTTCCTGGAAGTCATCCAGCGCCACAACCACCAGG
GTTTTGGAGCCGGCAACTTCAACTCACTGTTCAAGGCTTTCGAGGAGGAGCAGAACCTGCGGGGTAACCTCACCAACATGGAGACCAATG
GGGTGGTGCCCGGCATGTAAGCCCCGCCCACCCCACGGAGGCCACAGCCACACAGCCACGCCCCCTGATTCTGGAACTCGCCCAACTTCC
CTACTGGCTGCTCCCCTTGGGTCCCGCCCACCAGCGGACTCGGCCCCCAAGGCTCCGCCCACACTGACCACGCCCCTCGGCGGGGCCGCC

>44149_44149_4_LARP4-HPD_LARP4_chr12_50824353_ENST00000347328_HPD_chr12_122285120_ENST00000543163_length(amino acids)=327AA_BP=132
MLLFVEQVASKGTGLNPNAKVWQEIAPGNTDATPVTHGTESSWHEIAATSGAHPEGNAELSEDICKEYEVMYSSSCETTRNTTGIEESTD
GMILGPEDLSYQIYDVSGESNSAVSTEDLKECLKKQLEFCFSRYLKNLQFHRFWSVDDTQVHTEYSSLRSIVVANYEESIKMPINEPAPG
KKKSQIQEYVDYNGGAGVQHIALKTEDIITAIRHLRERGLEFLSVPSTYYKQLREKLKTAKIKVKENIDALEELKILVDYDEKGYLLQIF

--------------------------------------------------------------
>44149_44149_5_LARP4-HPD_LARP4_chr12_50824353_ENST00000398473_HPD_chr12_122285120_ENST00000289004_length(transcript)=1297nt_BP=510nt
CCGGGTGGAGGGGCAAGGCGAGTGTGTGTCCTTATCCTAGCAATTGGGGCGCGGGCCTGTGAGCCAGTTGGAGTTGCGGCGGCGGGAACG
ATTGGGCTGAGCAGAGGACGACATGTTGCTTTTCGTGGAGCAGGTAGCATCTAAAGGAACTGGTTTAAATCCTAATGCCAAAGTATGGCA
AGAAATTGCTCCTGGAAATACTGATGCCACCCCAGTAACTCATGGAACTGAAAGCTCTTGGCATGAAATAGCAGCTACATCAGGTGCTCA
TCCTGAGGGTAATGCAGAGCTCTCAGAAGATATATGTAAAGAATATGAAGTAATGTATTCTTCATCTTGTGAAACCACAAGAAATACTAC
AGGCATTGAAGAATCAACTGATGGGATGATTTTAGGACCAGAAGATCTGAGTTACCAAATATATGATGTTTCCGGAGAAAGCAATTCAGC
AGTTTCTACAGAAGACCTAAAAGAATGTCTGAAGAAACAATTAGAATTCTGTTTTTCACGGTACCTGAAAAACCTGCAGTTCCACCGCTT
CTGGTCCGTGGATGACACGCAGGTGCACACGGAATATAGCTCTCTGCGATCCATTGTGGTGGCCAACTATGAAGAGTCCATCAAGATGCC
CATCAATGAGCCAGCGCCTGGCAAGAAGAAGTCCCAGATCCAGGAATATGTGGACTATAACGGGGGCGCTGGGGTCCAGCACATCGCTCT
CAAGACCGAAGACATCATCACAGCGATTCGCCACTTGAGAGAGAGAGGCCTGGAGTTCTTATCTGTTCCCTCCACGTACTACAAACAACT
GCGGGAGAAGCTGAAGACGGCCAAGATCAAGGTGAAGGAGAACATTGATGCCCTGGAGGAGCTGAAAATCCTGGTGGACTACGACGAGAA
AGGCTACCTCCTGCAGATCTTCACCAAACCGGTGCAGGACCGGCCCACGCTCTTCCTGGAAGTCATCCAGCGCCACAACCACCAGGGTTT
TGGAGCCGGCAACTTCAACTCACTGTTCAAGGCTTTCGAGGAGGAGCAGAACCTGCGGGGTAACCTCACCAACATGGAGACCAATGGGGT
GGTGCCCGGCATGTAAGCCCCGCCCACCCCACGGAGGCCACAGCCACACAGCCACGCCCCCTGATTCTGGAACTCGCCCAACTTCCCTAC
TGGCTGCTCCCCTTGGGTCCCGCCCACCAGCGGACTCGGCCCCCAAGGCTCCGCCCACACTGACCACGCCCCTCGGCGGGGCCGCCCTCT

>44149_44149_5_LARP4-HPD_LARP4_chr12_50824353_ENST00000398473_HPD_chr12_122285120_ENST00000289004_length(amino acids)=327AA_BP=132
MLLFVEQVASKGTGLNPNAKVWQEIAPGNTDATPVTHGTESSWHEIAATSGAHPEGNAELSEDICKEYEVMYSSSCETTRNTTGIEESTD
GMILGPEDLSYQIYDVSGESNSAVSTEDLKECLKKQLEFCFSRYLKNLQFHRFWSVDDTQVHTEYSSLRSIVVANYEESIKMPINEPAPG
KKKSQIQEYVDYNGGAGVQHIALKTEDIITAIRHLRERGLEFLSVPSTYYKQLREKLKTAKIKVKENIDALEELKILVDYDEKGYLLQIF

--------------------------------------------------------------
>44149_44149_6_LARP4-HPD_LARP4_chr12_50824353_ENST00000398473_HPD_chr12_122285120_ENST00000543163_length(transcript)=1294nt_BP=510nt
CCGGGTGGAGGGGCAAGGCGAGTGTGTGTCCTTATCCTAGCAATTGGGGCGCGGGCCTGTGAGCCAGTTGGAGTTGCGGCGGCGGGAACG
ATTGGGCTGAGCAGAGGACGACATGTTGCTTTTCGTGGAGCAGGTAGCATCTAAAGGAACTGGTTTAAATCCTAATGCCAAAGTATGGCA
AGAAATTGCTCCTGGAAATACTGATGCCACCCCAGTAACTCATGGAACTGAAAGCTCTTGGCATGAAATAGCAGCTACATCAGGTGCTCA
TCCTGAGGGTAATGCAGAGCTCTCAGAAGATATATGTAAAGAATATGAAGTAATGTATTCTTCATCTTGTGAAACCACAAGAAATACTAC
AGGCATTGAAGAATCAACTGATGGGATGATTTTAGGACCAGAAGATCTGAGTTACCAAATATATGATGTTTCCGGAGAAAGCAATTCAGC
AGTTTCTACAGAAGACCTAAAAGAATGTCTGAAGAAACAATTAGAATTCTGTTTTTCACGGTACCTGAAAAACCTGCAGTTCCACCGCTT
CTGGTCCGTGGATGACACGCAGGTGCACACGGAATATAGCTCTCTGCGATCCATTGTGGTGGCCAACTATGAAGAGTCCATCAAGATGCC
CATCAATGAGCCAGCGCCTGGCAAGAAGAAGTCCCAGATCCAGGAATATGTGGACTATAACGGGGGCGCTGGGGTCCAGCACATCGCTCT
CAAGACCGAAGACATCATCACAGCGATTCGCCACTTGAGAGAGAGAGGCCTGGAGTTCTTATCTGTTCCCTCCACGTACTACAAACAACT
GCGGGAGAAGCTGAAGACGGCCAAGATCAAGGTGAAGGAGAACATTGATGCCCTGGAGGAGCTGAAAATCCTGGTGGACTACGACGAGAA
AGGCTACCTCCTGCAGATCTTCACCAAACCGGTGCAGGACCGGCCCACGCTCTTCCTGGAAGTCATCCAGCGCCACAACCACCAGGGTTT
TGGAGCCGGCAACTTCAACTCACTGTTCAAGGCTTTCGAGGAGGAGCAGAACCTGCGGGGTAACCTCACCAACATGGAGACCAATGGGGT
GGTGCCCGGCATGTAAGCCCCGCCCACCCCACGGAGGCCACAGCCACACAGCCACGCCCCCTGATTCTGGAACTCGCCCAACTTCCCTAC
TGGCTGCTCCCCTTGGGTCCCGCCCACCAGCGGACTCGGCCCCCAAGGCTCCGCCCACACTGACCACGCCCCTCGGCGGGGCCGCCCTCT

>44149_44149_6_LARP4-HPD_LARP4_chr12_50824353_ENST00000398473_HPD_chr12_122285120_ENST00000543163_length(amino acids)=327AA_BP=132
MLLFVEQVASKGTGLNPNAKVWQEIAPGNTDATPVTHGTESSWHEIAATSGAHPEGNAELSEDICKEYEVMYSSSCETTRNTTGIEESTD
GMILGPEDLSYQIYDVSGESNSAVSTEDLKECLKKQLEFCFSRYLKNLQFHRFWSVDDTQVHTEYSSLRSIVVANYEESIKMPINEPAPG
KKKSQIQEYVDYNGGAGVQHIALKTEDIITAIRHLRERGLEFLSVPSTYYKQLREKLKTAKIKVKENIDALEELKILVDYDEKGYLLQIF

--------------------------------------------------------------
>44149_44149_7_LARP4-HPD_LARP4_chr12_50824353_ENST00000429001_HPD_chr12_122285120_ENST00000289004_length(transcript)=1357nt_BP=570nt
AGGCCGCAGCGGCTGACGGCAGGGGAGGAGCCGGGTCCACTGCCGGGTGGAGGGGCAAGGCGAGTGTGTGTCCTTATCCTAGCAATTGGG
GCGCGGGCCTGTGAGCCAGTTGGAGTTGCGGCGGCGGGAACGATTGGGCTGAGCAGAGGACGACATGTTGCTTTTCGTGGAGCAGGTAGC
ATCTAAAGGAACTGGTTTAAATCCTAATGCCAAAGTATGGCAAGAAATTGCTCCTGGAAATACTGATGCCACCCCAGTAACTCATGGAAC
TGAAAGCTCTTGGCATGAAATAGCAGCTACATCAGGTGCTCATCCTGAGGTGTCTGTCTTTAATACAGGTAATGCAGAGCTCTCAGAAGA
TATATGTAAAGAATATGAAGTAATGTATTCTTCATCTTGTGAAACCACAAGAAATACTACAGGCATTGAAGAATCAACTGATGGGATGAT
TTTAGGACCAGAAGATCTGAGTTACCAAATATATGATGTTTCCGGAGAAAGCAATTCAGCAGTTTCTACAGAAGACCTAAAAGAATGTCT
GAAGAAACAATTAGAATTCTGTTTTTCACGGTACCTGAAAAACCTGCAGTTCCACCGCTTCTGGTCCGTGGATGACACGCAGGTGCACAC
GGAATATAGCTCTCTGCGATCCATTGTGGTGGCCAACTATGAAGAGTCCATCAAGATGCCCATCAATGAGCCAGCGCCTGGCAAGAAGAA
GTCCCAGATCCAGGAATATGTGGACTATAACGGGGGCGCTGGGGTCCAGCACATCGCTCTCAAGACCGAAGACATCATCACAGCGATTCG
CCACTTGAGAGAGAGAGGCCTGGAGTTCTTATCTGTTCCCTCCACGTACTACAAACAACTGCGGGAGAAGCTGAAGACGGCCAAGATCAA
GGTGAAGGAGAACATTGATGCCCTGGAGGAGCTGAAAATCCTGGTGGACTACGACGAGAAAGGCTACCTCCTGCAGATCTTCACCAAACC
GGTGCAGGACCGGCCCACGCTCTTCCTGGAAGTCATCCAGCGCCACAACCACCAGGGTTTTGGAGCCGGCAACTTCAACTCACTGTTCAA
GGCTTTCGAGGAGGAGCAGAACCTGCGGGGTAACCTCACCAACATGGAGACCAATGGGGTGGTGCCCGGCATGTAAGCCCCGCCCACCCC
ACGGAGGCCACAGCCACACAGCCACGCCCCCTGATTCTGGAACTCGCCCAACTTCCCTACTGGCTGCTCCCCTTGGGTCCCGCCCACCAG
CGGACTCGGCCCCCAAGGCTCCGCCCACACTGACCACGCCCCTCGGCGGGGCCGCCCTCTGCTCCAGCCCTCCCGATTAAAGCGTGCCCC

>44149_44149_7_LARP4-HPD_LARP4_chr12_50824353_ENST00000429001_HPD_chr12_122285120_ENST00000289004_length(amino acids)=333AA_BP=138
MLLFVEQVASKGTGLNPNAKVWQEIAPGNTDATPVTHGTESSWHEIAATSGAHPEVSVFNTGNAELSEDICKEYEVMYSSSCETTRNTTG
IEESTDGMILGPEDLSYQIYDVSGESNSAVSTEDLKECLKKQLEFCFSRYLKNLQFHRFWSVDDTQVHTEYSSLRSIVVANYEESIKMPI
NEPAPGKKKSQIQEYVDYNGGAGVQHIALKTEDIITAIRHLRERGLEFLSVPSTYYKQLREKLKTAKIKVKENIDALEELKILVDYDEKG

--------------------------------------------------------------
>44149_44149_8_LARP4-HPD_LARP4_chr12_50824353_ENST00000429001_HPD_chr12_122285120_ENST00000543163_length(transcript)=1354nt_BP=570nt
AGGCCGCAGCGGCTGACGGCAGGGGAGGAGCCGGGTCCACTGCCGGGTGGAGGGGCAAGGCGAGTGTGTGTCCTTATCCTAGCAATTGGG
GCGCGGGCCTGTGAGCCAGTTGGAGTTGCGGCGGCGGGAACGATTGGGCTGAGCAGAGGACGACATGTTGCTTTTCGTGGAGCAGGTAGC
ATCTAAAGGAACTGGTTTAAATCCTAATGCCAAAGTATGGCAAGAAATTGCTCCTGGAAATACTGATGCCACCCCAGTAACTCATGGAAC
TGAAAGCTCTTGGCATGAAATAGCAGCTACATCAGGTGCTCATCCTGAGGTGTCTGTCTTTAATACAGGTAATGCAGAGCTCTCAGAAGA
TATATGTAAAGAATATGAAGTAATGTATTCTTCATCTTGTGAAACCACAAGAAATACTACAGGCATTGAAGAATCAACTGATGGGATGAT
TTTAGGACCAGAAGATCTGAGTTACCAAATATATGATGTTTCCGGAGAAAGCAATTCAGCAGTTTCTACAGAAGACCTAAAAGAATGTCT
GAAGAAACAATTAGAATTCTGTTTTTCACGGTACCTGAAAAACCTGCAGTTCCACCGCTTCTGGTCCGTGGATGACACGCAGGTGCACAC
GGAATATAGCTCTCTGCGATCCATTGTGGTGGCCAACTATGAAGAGTCCATCAAGATGCCCATCAATGAGCCAGCGCCTGGCAAGAAGAA
GTCCCAGATCCAGGAATATGTGGACTATAACGGGGGCGCTGGGGTCCAGCACATCGCTCTCAAGACCGAAGACATCATCACAGCGATTCG
CCACTTGAGAGAGAGAGGCCTGGAGTTCTTATCTGTTCCCTCCACGTACTACAAACAACTGCGGGAGAAGCTGAAGACGGCCAAGATCAA
GGTGAAGGAGAACATTGATGCCCTGGAGGAGCTGAAAATCCTGGTGGACTACGACGAGAAAGGCTACCTCCTGCAGATCTTCACCAAACC
GGTGCAGGACCGGCCCACGCTCTTCCTGGAAGTCATCCAGCGCCACAACCACCAGGGTTTTGGAGCCGGCAACTTCAACTCACTGTTCAA
GGCTTTCGAGGAGGAGCAGAACCTGCGGGGTAACCTCACCAACATGGAGACCAATGGGGTGGTGCCCGGCATGTAAGCCCCGCCCACCCC
ACGGAGGCCACAGCCACACAGCCACGCCCCCTGATTCTGGAACTCGCCCAACTTCCCTACTGGCTGCTCCCCTTGGGTCCCGCCCACCAG
CGGACTCGGCCCCCAAGGCTCCGCCCACACTGACCACGCCCCTCGGCGGGGCCGCCCTCTGCTCCAGCCCTCCCGATTAAAGCGTGCCCC

>44149_44149_8_LARP4-HPD_LARP4_chr12_50824353_ENST00000429001_HPD_chr12_122285120_ENST00000543163_length(amino acids)=333AA_BP=138
MLLFVEQVASKGTGLNPNAKVWQEIAPGNTDATPVTHGTESSWHEIAATSGAHPEVSVFNTGNAELSEDICKEYEVMYSSSCETTRNTTG
IEESTDGMILGPEDLSYQIYDVSGESNSAVSTEDLKECLKKQLEFCFSRYLKNLQFHRFWSVDDTQVHTEYSSLRSIVVANYEESIKMPI
NEPAPGKKKSQIQEYVDYNGGAGVQHIALKTEDIITAIRHLRERGLEFLSVPSTYYKQLREKLKTAKIKVKENIDALEELKILVDYDEKG

--------------------------------------------------------------
>44149_44149_9_LARP4-HPD_LARP4_chr12_50824353_ENST00000518444_HPD_chr12_122285120_ENST00000289004_length(transcript)=1264nt_BP=477nt
CTTATCCTAGCAATTGGGGCGCGGGCCTGTGAGCCAGTTGGAGTTGCGGCGGCGGGAACGATTGGGCTGAGCAGAGGACGACATGTTGCT
TTTCGTGGAGGTAGCATCTAAAGGAACTGGTTTAAATCCTAATGCCAAAGTATGGCAAGAAATTGCTCCTGGAAATACTGATGCCACCCC
AGTAACTCATGGAACTGAAAGCTCTTGGCATGAAATAGCAGCTACATCAGGTGCTCATCCTGAGGGTAATGCAGAGCTCTCAGAAGATAT
ATGTAAAGAATATGAAGTAATGTATTCTTCATCTTGTGAAACCACAAGAAATACTACAGGCATTGAAGAATCAACTGATGGGATGATTTT
AGGACCAGAAGATCTGAGTTACCAAATATATGATGTTTCCGGAGAAAGCAATTCAGCAGTTTCTACAGAAGACCTAAAAGAATGTCTGAA
GAAACAATTAGAATTCTGTTTTTCACGGTACCTGAAAAACCTGCAGTTCCACCGCTTCTGGTCCGTGGATGACACGCAGGTGCACACGGA
ATATAGCTCTCTGCGATCCATTGTGGTGGCCAACTATGAAGAGTCCATCAAGATGCCCATCAATGAGCCAGCGCCTGGCAAGAAGAAGTC
CCAGATCCAGGAATATGTGGACTATAACGGGGGCGCTGGGGTCCAGCACATCGCTCTCAAGACCGAAGACATCATCACAGCGATTCGCCA
CTTGAGAGAGAGAGGCCTGGAGTTCTTATCTGTTCCCTCCACGTACTACAAACAACTGCGGGAGAAGCTGAAGACGGCCAAGATCAAGGT
GAAGGAGAACATTGATGCCCTGGAGGAGCTGAAAATCCTGGTGGACTACGACGAGAAAGGCTACCTCCTGCAGATCTTCACCAAACCGGT
GCAGGACCGGCCCACGCTCTTCCTGGAAGTCATCCAGCGCCACAACCACCAGGGTTTTGGAGCCGGCAACTTCAACTCACTGTTCAAGGC
TTTCGAGGAGGAGCAGAACCTGCGGGGTAACCTCACCAACATGGAGACCAATGGGGTGGTGCCCGGCATGTAAGCCCCGCCCACCCCACG
GAGGCCACAGCCACACAGCCACGCCCCCTGATTCTGGAACTCGCCCAACTTCCCTACTGGCTGCTCCCCTTGGGTCCCGCCCACCAGCGG
ACTCGGCCCCCAAGGCTCCGCCCACACTGACCACGCCCCTCGGCGGGGCCGCCCTCTGCTCCAGCCCTCCCGATTAAAGCGTGCCCCGGT

>44149_44149_9_LARP4-HPD_LARP4_chr12_50824353_ENST00000518444_HPD_chr12_122285120_ENST00000289004_length(amino acids)=326AA_BP=131
MLLFVEVASKGTGLNPNAKVWQEIAPGNTDATPVTHGTESSWHEIAATSGAHPEGNAELSEDICKEYEVMYSSSCETTRNTTGIEESTDG
MILGPEDLSYQIYDVSGESNSAVSTEDLKECLKKQLEFCFSRYLKNLQFHRFWSVDDTQVHTEYSSLRSIVVANYEESIKMPINEPAPGK
KKSQIQEYVDYNGGAGVQHIALKTEDIITAIRHLRERGLEFLSVPSTYYKQLREKLKTAKIKVKENIDALEELKILVDYDEKGYLLQIFT

--------------------------------------------------------------
>44149_44149_10_LARP4-HPD_LARP4_chr12_50824353_ENST00000518444_HPD_chr12_122285120_ENST00000543163_length(transcript)=1261nt_BP=477nt
CTTATCCTAGCAATTGGGGCGCGGGCCTGTGAGCCAGTTGGAGTTGCGGCGGCGGGAACGATTGGGCTGAGCAGAGGACGACATGTTGCT
TTTCGTGGAGGTAGCATCTAAAGGAACTGGTTTAAATCCTAATGCCAAAGTATGGCAAGAAATTGCTCCTGGAAATACTGATGCCACCCC
AGTAACTCATGGAACTGAAAGCTCTTGGCATGAAATAGCAGCTACATCAGGTGCTCATCCTGAGGGTAATGCAGAGCTCTCAGAAGATAT
ATGTAAAGAATATGAAGTAATGTATTCTTCATCTTGTGAAACCACAAGAAATACTACAGGCATTGAAGAATCAACTGATGGGATGATTTT
AGGACCAGAAGATCTGAGTTACCAAATATATGATGTTTCCGGAGAAAGCAATTCAGCAGTTTCTACAGAAGACCTAAAAGAATGTCTGAA
GAAACAATTAGAATTCTGTTTTTCACGGTACCTGAAAAACCTGCAGTTCCACCGCTTCTGGTCCGTGGATGACACGCAGGTGCACACGGA
ATATAGCTCTCTGCGATCCATTGTGGTGGCCAACTATGAAGAGTCCATCAAGATGCCCATCAATGAGCCAGCGCCTGGCAAGAAGAAGTC
CCAGATCCAGGAATATGTGGACTATAACGGGGGCGCTGGGGTCCAGCACATCGCTCTCAAGACCGAAGACATCATCACAGCGATTCGCCA
CTTGAGAGAGAGAGGCCTGGAGTTCTTATCTGTTCCCTCCACGTACTACAAACAACTGCGGGAGAAGCTGAAGACGGCCAAGATCAAGGT
GAAGGAGAACATTGATGCCCTGGAGGAGCTGAAAATCCTGGTGGACTACGACGAGAAAGGCTACCTCCTGCAGATCTTCACCAAACCGGT
GCAGGACCGGCCCACGCTCTTCCTGGAAGTCATCCAGCGCCACAACCACCAGGGTTTTGGAGCCGGCAACTTCAACTCACTGTTCAAGGC
TTTCGAGGAGGAGCAGAACCTGCGGGGTAACCTCACCAACATGGAGACCAATGGGGTGGTGCCCGGCATGTAAGCCCCGCCCACCCCACG
GAGGCCACAGCCACACAGCCACGCCCCCTGATTCTGGAACTCGCCCAACTTCCCTACTGGCTGCTCCCCTTGGGTCCCGCCCACCAGCGG
ACTCGGCCCCCAAGGCTCCGCCCACACTGACCACGCCCCTCGGCGGGGCCGCCCTCTGCTCCAGCCCTCCCGATTAAAGCGTGCCCCGGT

>44149_44149_10_LARP4-HPD_LARP4_chr12_50824353_ENST00000518444_HPD_chr12_122285120_ENST00000543163_length(amino acids)=326AA_BP=131
MLLFVEVASKGTGLNPNAKVWQEIAPGNTDATPVTHGTESSWHEIAATSGAHPEGNAELSEDICKEYEVMYSSSCETTRNTTGIEESTDG
MILGPEDLSYQIYDVSGESNSAVSTEDLKECLKKQLEFCFSRYLKNLQFHRFWSVDDTQVHTEYSSLRSIVVANYEESIKMPINEPAPGK
KKSQIQEYVDYNGGAGVQHIALKTEDIITAIRHLRERGLEFLSVPSTYYKQLREKLKTAKIKVKENIDALEELKILVDYDEKGYLLQIFT

--------------------------------------------------------------
>44149_44149_11_LARP4-HPD_LARP4_chr12_50824353_ENST00000518561_HPD_chr12_122285120_ENST00000289004_length(transcript)=1289nt_BP=502nt
TGTGAGCCAGTTGGAGTTGCGGCGGCGGGAACGATTGGGCTGAGCAGAGGACGACATGTTGCTTTTCGTGGAGCATTTATGGGGTTAAGT
GGCATGGGATTTCTGTTTCTGATAGTAAATAGCAGGTAGCATCTAAAGGAACTGGTTTAAATCCTAATGCCAAAGTATGGCAAGAAATTG
CTCCTGGAAATACTGATGCCACCCCAGTAACTCATGGAACTGAAAGCTCTTGGCATGAAATAGCAGCTACATCAGGTGCTCATCCTGAGG
GTAATGCAGAGCTCTCAGAAGATATATGTAAAGAATATGAAGTAATGTATTCTTCATCTTGTGAAACCACAAGAAATACTACAGGCATTG
AAGAATCAACTGATGGGATGATTTTAGGACCAGAAGATCTGAGTTACCAAATATATGATGTTTCCGGAGAAAGCAATTCAGCAGTTTCTA
CAGAAGACCTAAAAGAATGTCTGAAGAAACAATTAGAATTCTGTTTTTCACGGTACCTGAAAAACCTGCAGTTCCACCGCTTCTGGTCCG
TGGATGACACGCAGGTGCACACGGAATATAGCTCTCTGCGATCCATTGTGGTGGCCAACTATGAAGAGTCCATCAAGATGCCCATCAATG
AGCCAGCGCCTGGCAAGAAGAAGTCCCAGATCCAGGAATATGTGGACTATAACGGGGGCGCTGGGGTCCAGCACATCGCTCTCAAGACCG
AAGACATCATCACAGCGATTCGCCACTTGAGAGAGAGAGGCCTGGAGTTCTTATCTGTTCCCTCCACGTACTACAAACAACTGCGGGAGA
AGCTGAAGACGGCCAAGATCAAGGTGAAGGAGAACATTGATGCCCTGGAGGAGCTGAAAATCCTGGTGGACTACGACGAGAAAGGCTACC
TCCTGCAGATCTTCACCAAACCGGTGCAGGACCGGCCCACGCTCTTCCTGGAAGTCATCCAGCGCCACAACCACCAGGGTTTTGGAGCCG
GCAACTTCAACTCACTGTTCAAGGCTTTCGAGGAGGAGCAGAACCTGCGGGGTAACCTCACCAACATGGAGACCAATGGGGTGGTGCCCG
GCATGTAAGCCCCGCCCACCCCACGGAGGCCACAGCCACACAGCCACGCCCCCTGATTCTGGAACTCGCCCAACTTCCCTACTGGCTGCT
CCCCTTGGGTCCCGCCCACCAGCGGACTCGGCCCCCAAGGCTCCGCCCACACTGACCACGCCCCTCGGCGGGGCCGCCCTCTGCTCCAGC

>44149_44149_11_LARP4-HPD_LARP4_chr12_50824353_ENST00000518561_HPD_chr12_122285120_ENST00000289004_length(amino acids)=257AA_BP=62
MYSSSCETTRNTTGIEESTDGMILGPEDLSYQIYDVSGESNSAVSTEDLKECLKKQLEFCFSRYLKNLQFHRFWSVDDTQVHTEYSSLRS
IVVANYEESIKMPINEPAPGKKKSQIQEYVDYNGGAGVQHIALKTEDIITAIRHLRERGLEFLSVPSTYYKQLREKLKTAKIKVKENIDA

--------------------------------------------------------------
>44149_44149_12_LARP4-HPD_LARP4_chr12_50824353_ENST00000518561_HPD_chr12_122285120_ENST00000543163_length(transcript)=1286nt_BP=502nt
TGTGAGCCAGTTGGAGTTGCGGCGGCGGGAACGATTGGGCTGAGCAGAGGACGACATGTTGCTTTTCGTGGAGCATTTATGGGGTTAAGT
GGCATGGGATTTCTGTTTCTGATAGTAAATAGCAGGTAGCATCTAAAGGAACTGGTTTAAATCCTAATGCCAAAGTATGGCAAGAAATTG
CTCCTGGAAATACTGATGCCACCCCAGTAACTCATGGAACTGAAAGCTCTTGGCATGAAATAGCAGCTACATCAGGTGCTCATCCTGAGG
GTAATGCAGAGCTCTCAGAAGATATATGTAAAGAATATGAAGTAATGTATTCTTCATCTTGTGAAACCACAAGAAATACTACAGGCATTG
AAGAATCAACTGATGGGATGATTTTAGGACCAGAAGATCTGAGTTACCAAATATATGATGTTTCCGGAGAAAGCAATTCAGCAGTTTCTA
CAGAAGACCTAAAAGAATGTCTGAAGAAACAATTAGAATTCTGTTTTTCACGGTACCTGAAAAACCTGCAGTTCCACCGCTTCTGGTCCG
TGGATGACACGCAGGTGCACACGGAATATAGCTCTCTGCGATCCATTGTGGTGGCCAACTATGAAGAGTCCATCAAGATGCCCATCAATG
AGCCAGCGCCTGGCAAGAAGAAGTCCCAGATCCAGGAATATGTGGACTATAACGGGGGCGCTGGGGTCCAGCACATCGCTCTCAAGACCG
AAGACATCATCACAGCGATTCGCCACTTGAGAGAGAGAGGCCTGGAGTTCTTATCTGTTCCCTCCACGTACTACAAACAACTGCGGGAGA
AGCTGAAGACGGCCAAGATCAAGGTGAAGGAGAACATTGATGCCCTGGAGGAGCTGAAAATCCTGGTGGACTACGACGAGAAAGGCTACC
TCCTGCAGATCTTCACCAAACCGGTGCAGGACCGGCCCACGCTCTTCCTGGAAGTCATCCAGCGCCACAACCACCAGGGTTTTGGAGCCG
GCAACTTCAACTCACTGTTCAAGGCTTTCGAGGAGGAGCAGAACCTGCGGGGTAACCTCACCAACATGGAGACCAATGGGGTGGTGCCCG
GCATGTAAGCCCCGCCCACCCCACGGAGGCCACAGCCACACAGCCACGCCCCCTGATTCTGGAACTCGCCCAACTTCCCTACTGGCTGCT
CCCCTTGGGTCCCGCCCACCAGCGGACTCGGCCCCCAAGGCTCCGCCCACACTGACCACGCCCCTCGGCGGGGCCGCCCTCTGCTCCAGC

>44149_44149_12_LARP4-HPD_LARP4_chr12_50824353_ENST00000518561_HPD_chr12_122285120_ENST00000543163_length(amino acids)=257AA_BP=62
MYSSSCETTRNTTGIEESTDGMILGPEDLSYQIYDVSGESNSAVSTEDLKECLKKQLEFCFSRYLKNLQFHRFWSVDDTQVHTEYSSLRS
IVVANYEESIKMPINEPAPGKKKSQIQEYVDYNGGAGVQHIALKTEDIITAIRHLRERGLEFLSVPSTYYKQLREKLKTAKIKVKENIDA

--------------------------------------------------------------
>44149_44149_13_LARP4-HPD_LARP4_chr12_50824353_ENST00000522085_HPD_chr12_122285120_ENST00000289004_length(transcript)=1288nt_BP=501nt
GGGGCAAGGCGAGTGTGTGTCCTTATCCTAGCAATTGGGGCGCGGGCCTGTGAGCCAGTTGGAGTTGCGGCGGCGGGAACGATTGGGCTG
AGCAGAGGACGACATGTTGCTTTTCGTGGAGCAGGTAGCATCTAAAGGAACTGGTTTAAATCCTAATGCCAAAGTATGGCAAGAAATTGC
TCCTGGAAATACTGATGCCACCCCAGTAACTCATGGAACTGAAAGCTCTTGGCATGAAATAGCAGCTACATCAGGTGCTCATCCTGAGGG
TAATGCAGAGCTCTCAGAAGATATATGTAAAGAATATGAAGTAATGTATTCTTCATCTTGTGAAACCACAAGAAATACTACAGGCATTGA
AGAATCAACTGATGGGATGATTTTAGGACCAGAAGATCTGAGTTACCAAATATATGATGTTTCCGGAGAAAGCAATTCAGCAGTTTCTAC
AGAAGACCTAAAAGAATGTCTGAAGAAACAATTAGAATTCTGTTTTTCACGGTACCTGAAAAACCTGCAGTTCCACCGCTTCTGGTCCGT
GGATGACACGCAGGTGCACACGGAATATAGCTCTCTGCGATCCATTGTGGTGGCCAACTATGAAGAGTCCATCAAGATGCCCATCAATGA
GCCAGCGCCTGGCAAGAAGAAGTCCCAGATCCAGGAATATGTGGACTATAACGGGGGCGCTGGGGTCCAGCACATCGCTCTCAAGACCGA
AGACATCATCACAGCGATTCGCCACTTGAGAGAGAGAGGCCTGGAGTTCTTATCTGTTCCCTCCACGTACTACAAACAACTGCGGGAGAA
GCTGAAGACGGCCAAGATCAAGGTGAAGGAGAACATTGATGCCCTGGAGGAGCTGAAAATCCTGGTGGACTACGACGAGAAAGGCTACCT
CCTGCAGATCTTCACCAAACCGGTGCAGGACCGGCCCACGCTCTTCCTGGAAGTCATCCAGCGCCACAACCACCAGGGTTTTGGAGCCGG
CAACTTCAACTCACTGTTCAAGGCTTTCGAGGAGGAGCAGAACCTGCGGGGTAACCTCACCAACATGGAGACCAATGGGGTGGTGCCCGG
CATGTAAGCCCCGCCCACCCCACGGAGGCCACAGCCACACAGCCACGCCCCCTGATTCTGGAACTCGCCCAACTTCCCTACTGGCTGCTC
CCCTTGGGTCCCGCCCACCAGCGGACTCGGCCCCCAAGGCTCCGCCCACACTGACCACGCCCCTCGGCGGGGCCGCCCTCTGCTCCAGCC

>44149_44149_13_LARP4-HPD_LARP4_chr12_50824353_ENST00000522085_HPD_chr12_122285120_ENST00000289004_length(amino acids)=327AA_BP=132
MLLFVEQVASKGTGLNPNAKVWQEIAPGNTDATPVTHGTESSWHEIAATSGAHPEGNAELSEDICKEYEVMYSSSCETTRNTTGIEESTD
GMILGPEDLSYQIYDVSGESNSAVSTEDLKECLKKQLEFCFSRYLKNLQFHRFWSVDDTQVHTEYSSLRSIVVANYEESIKMPINEPAPG
KKKSQIQEYVDYNGGAGVQHIALKTEDIITAIRHLRERGLEFLSVPSTYYKQLREKLKTAKIKVKENIDALEELKILVDYDEKGYLLQIF

--------------------------------------------------------------
>44149_44149_14_LARP4-HPD_LARP4_chr12_50824353_ENST00000522085_HPD_chr12_122285120_ENST00000543163_length(transcript)=1285nt_BP=501nt
GGGGCAAGGCGAGTGTGTGTCCTTATCCTAGCAATTGGGGCGCGGGCCTGTGAGCCAGTTGGAGTTGCGGCGGCGGGAACGATTGGGCTG
AGCAGAGGACGACATGTTGCTTTTCGTGGAGCAGGTAGCATCTAAAGGAACTGGTTTAAATCCTAATGCCAAAGTATGGCAAGAAATTGC
TCCTGGAAATACTGATGCCACCCCAGTAACTCATGGAACTGAAAGCTCTTGGCATGAAATAGCAGCTACATCAGGTGCTCATCCTGAGGG
TAATGCAGAGCTCTCAGAAGATATATGTAAAGAATATGAAGTAATGTATTCTTCATCTTGTGAAACCACAAGAAATACTACAGGCATTGA
AGAATCAACTGATGGGATGATTTTAGGACCAGAAGATCTGAGTTACCAAATATATGATGTTTCCGGAGAAAGCAATTCAGCAGTTTCTAC
AGAAGACCTAAAAGAATGTCTGAAGAAACAATTAGAATTCTGTTTTTCACGGTACCTGAAAAACCTGCAGTTCCACCGCTTCTGGTCCGT
GGATGACACGCAGGTGCACACGGAATATAGCTCTCTGCGATCCATTGTGGTGGCCAACTATGAAGAGTCCATCAAGATGCCCATCAATGA
GCCAGCGCCTGGCAAGAAGAAGTCCCAGATCCAGGAATATGTGGACTATAACGGGGGCGCTGGGGTCCAGCACATCGCTCTCAAGACCGA
AGACATCATCACAGCGATTCGCCACTTGAGAGAGAGAGGCCTGGAGTTCTTATCTGTTCCCTCCACGTACTACAAACAACTGCGGGAGAA
GCTGAAGACGGCCAAGATCAAGGTGAAGGAGAACATTGATGCCCTGGAGGAGCTGAAAATCCTGGTGGACTACGACGAGAAAGGCTACCT
CCTGCAGATCTTCACCAAACCGGTGCAGGACCGGCCCACGCTCTTCCTGGAAGTCATCCAGCGCCACAACCACCAGGGTTTTGGAGCCGG
CAACTTCAACTCACTGTTCAAGGCTTTCGAGGAGGAGCAGAACCTGCGGGGTAACCTCACCAACATGGAGACCAATGGGGTGGTGCCCGG
CATGTAAGCCCCGCCCACCCCACGGAGGCCACAGCCACACAGCCACGCCCCCTGATTCTGGAACTCGCCCAACTTCCCTACTGGCTGCTC
CCCTTGGGTCCCGCCCACCAGCGGACTCGGCCCCCAAGGCTCCGCCCACACTGACCACGCCCCTCGGCGGGGCCGCCCTCTGCTCCAGCC

>44149_44149_14_LARP4-HPD_LARP4_chr12_50824353_ENST00000522085_HPD_chr12_122285120_ENST00000543163_length(amino acids)=327AA_BP=132
MLLFVEQVASKGTGLNPNAKVWQEIAPGNTDATPVTHGTESSWHEIAATSGAHPEGNAELSEDICKEYEVMYSSSCETTRNTTGIEESTD
GMILGPEDLSYQIYDVSGESNSAVSTEDLKECLKKQLEFCFSRYLKNLQFHRFWSVDDTQVHTEYSSLRSIVVANYEESIKMPINEPAPG
KKKSQIQEYVDYNGGAGVQHIALKTEDIITAIRHLRERGLEFLSVPSTYYKQLREKLKTAKIKVKENIDALEELKILVDYDEKGYLLQIF

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Fusion Gene PPI Analysis for LARP4-HPD


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneLARP4chr12:50824353chr12:122285120ENST00000293618+41513_22132.66666666666666654.0PABPC1
HgeneLARP4chr12:50824353chr12:122285120ENST00000347328+41513_22132.66666666666666654.0PABPC1
HgeneLARP4chr12:50824353chr12:122285120ENST00000398473+41613_22132.66666666666666725.0PABPC1
HgeneLARP4chr12:50824353chr12:122285120ENST00000429001+41613_22138.66666666666666731.0PABPC1
HgeneLARP4chr12:50824353chr12:122285120ENST00000518444+41613_22131.66666666666666724.0PABPC1
HgeneLARP4chr12:50824353chr12:122285120ENST00000522085+41113_22132.66666666666666446.0PABPC1


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneLARP4chr12:50824353chr12:122285120ENST00000293618+415111_303132.66666666666666654.0the poly-A tract of mRNA
HgeneLARP4chr12:50824353chr12:122285120ENST00000347328+415111_303132.66666666666666654.0the poly-A tract of mRNA
HgeneLARP4chr12:50824353chr12:122285120ENST00000398473+416111_303132.66666666666666725.0the poly-A tract of mRNA
HgeneLARP4chr12:50824353chr12:122285120ENST00000429001+416111_303138.66666666666666731.0the poly-A tract of mRNA
HgeneLARP4chr12:50824353chr12:122285120ENST00000518444+416111_303131.66666666666666724.0the poly-A tract of mRNA
HgeneLARP4chr12:50824353chr12:122285120ENST00000522085+411111_303132.66666666666666446.0the poly-A tract of mRNA


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for LARP4-HPD


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for LARP4-HPD


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource