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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:LARS2-TBL1XR1 (FusionGDB2 ID:44167)

Fusion Gene Summary for LARS2-TBL1XR1

check button Fusion gene summary
Fusion gene informationFusion gene name: LARS2-TBL1XR1
Fusion gene ID: 44167
HgeneTgene
Gene symbol

LARS2

TBL1XR1

Gene ID

23395

79718

Gene nameleucyl-tRNA synthetase 2, mitochondrialTBL1X receptor 1
SynonymsHLASA|LEURS|PRLTS4|mtLeuRSC21|DC42|IRA1|MRD41|TBLR1
Cytomap

3p21.31

3q26.32

Type of geneprotein-codingprotein-coding
Descriptionprobable leucine--tRNA ligase, mitochondrialleucine tRNA ligase 2, mitochondrialleucine tRNA ligase 2, mitocondrialleucine translaseprobable leucyl-tRNA synthetase, mitochondrialF-box-like/WD repeat-containing protein TBL1XR1TBL1-related protein 1nuclear receptor co-repressor/HDAC3 complex subunitnuclear receptor corepressor/HDAC3 complex subunit TBLR1transducin beta like 1 X-linked receptor 1
Modification date2020031320200313
UniProtAcc

Q15031

.
Ensembl transtripts involved in fusion geneENST00000265537, ENST00000414984, 
ENST00000415258, ENST00000467936, 
ENST00000430069, ENST00000457928, 
Fusion gene scores* DoF score5 X 4 X 4=8011 X 11 X 5=605
# samples 513
** MAII scorelog2(5/80*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/605*10)=-2.2184235191335
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: LARS2 [Title/Abstract] AND TBL1XR1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointLARS2(45461221)-TBL1XR1(176769514), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneLARS2

GO:0006429

leucyl-tRNA aminoacylation

10684970

TgeneTBL1XR1

GO:0000122

negative regulation of transcription by RNA polymerase II

12628926

TgeneTBL1XR1

GO:0045893

positive regulation of transcription, DNA-templated

18193033

TgeneTBL1XR1

GO:0045944

positive regulation of transcription by RNA polymerase II

18193033


check buttonFusion gene breakpoints across LARS2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TBL1XR1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4DLBCTCGA-FA-A4XK-01ALARS2chr3

45461221

-TBL1XR1chr3

176769514

-
ChimerDB4DLBCTCGA-FA-A4XK-01ALARS2chr3

45461221

+TBL1XR1chr3

176769514

-


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Fusion Gene ORF analysis for LARS2-TBL1XR1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000265537ENST00000430069LARS2chr3

45461221

+TBL1XR1chr3

176769514

-
In-frameENST00000265537ENST00000457928LARS2chr3

45461221

+TBL1XR1chr3

176769514

-
In-frameENST00000414984ENST00000430069LARS2chr3

45461221

+TBL1XR1chr3

176769514

-
In-frameENST00000414984ENST00000457928LARS2chr3

45461221

+TBL1XR1chr3

176769514

-
In-frameENST00000415258ENST00000430069LARS2chr3

45461221

+TBL1XR1chr3

176769514

-
In-frameENST00000415258ENST00000457928LARS2chr3

45461221

+TBL1XR1chr3

176769514

-
intron-3CDSENST00000467936ENST00000430069LARS2chr3

45461221

+TBL1XR1chr3

176769514

-
intron-3CDSENST00000467936ENST00000457928LARS2chr3

45461221

+TBL1XR1chr3

176769514

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000265537LARS2chr345461221+ENST00000430069TBL1XR1chr3176769514-82627782622118618
ENST00000265537LARS2chr345461221+ENST00000457928TBL1XR1chr3176769514-42977782622118618
ENST00000415258LARS2chr345461221+ENST00000430069TBL1XR1chr3176769514-81416571411997618
ENST00000415258LARS2chr345461221+ENST00000457928TBL1XR1chr3176769514-41766571411997618
ENST00000414984LARS2chr345461221+ENST00000430069TBL1XR1chr3176769514-80095251381865575
ENST00000414984LARS2chr345461221+ENST00000457928TBL1XR1chr3176769514-40445251381865575

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000265537ENST00000430069LARS2chr345461221+TBL1XR1chr3176769514-0.0002695630.9997304
ENST00000265537ENST00000457928LARS2chr345461221+TBL1XR1chr3176769514-0.0005156450.9994843
ENST00000415258ENST00000430069LARS2chr345461221+TBL1XR1chr3176769514-0.000274990.99972504
ENST00000415258ENST00000457928LARS2chr345461221+TBL1XR1chr3176769514-0.0005508920.9994491
ENST00000414984ENST00000430069LARS2chr345461221+TBL1XR1chr3176769514-0.0002427050.99975735
ENST00000414984ENST00000457928LARS2chr345461221+TBL1XR1chr3176769514-0.0005065670.99949336

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Fusion Genomic Features for LARS2-TBL1XR1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for LARS2-TBL1XR1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:45461221/chr3:176769514)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LARS2

Q15031

.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLARS2chr3:45461221chr3:176769514ENST00000265537+62292_102172904.0MotifNote='HIGH' region
HgeneLARS2chr3:45461221chr3:176769514ENST00000415258+52192_102172904.0MotifNote='HIGH' region
TgeneTBL1XR1chr3:45461221chr3:176769514ENST00000430069316108_11868515.0Compositional biasNote=Poly-Ala
TgeneTBL1XR1chr3:45461221chr3:176769514ENST00000457928316108_11868515.0Compositional biasNote=Poly-Ala
TgeneTBL1XR1chr3:45461221chr3:176769514ENST00000430069316167_20668515.0RepeatNote=WD 1
TgeneTBL1XR1chr3:45461221chr3:176769514ENST00000430069316223_26268515.0RepeatNote=WD 2
TgeneTBL1XR1chr3:45461221chr3:176769514ENST00000430069316264_30368515.0RepeatNote=WD 3
TgeneTBL1XR1chr3:45461221chr3:176769514ENST00000430069316306_34468515.0RepeatNote=WD 4
TgeneTBL1XR1chr3:45461221chr3:176769514ENST00000430069316347_38668515.0RepeatNote=WD 5
TgeneTBL1XR1chr3:45461221chr3:176769514ENST00000430069316389_43768515.0RepeatNote=WD 6
TgeneTBL1XR1chr3:45461221chr3:176769514ENST00000430069316440_47968515.0RepeatNote=WD 7
TgeneTBL1XR1chr3:45461221chr3:176769514ENST00000430069316481_51368515.0RepeatNote=WD 8
TgeneTBL1XR1chr3:45461221chr3:176769514ENST00000457928316167_20668515.0RepeatNote=WD 1
TgeneTBL1XR1chr3:45461221chr3:176769514ENST00000457928316223_26268515.0RepeatNote=WD 2
TgeneTBL1XR1chr3:45461221chr3:176769514ENST00000457928316264_30368515.0RepeatNote=WD 3
TgeneTBL1XR1chr3:45461221chr3:176769514ENST00000457928316306_34468515.0RepeatNote=WD 4
TgeneTBL1XR1chr3:45461221chr3:176769514ENST00000457928316347_38668515.0RepeatNote=WD 5
TgeneTBL1XR1chr3:45461221chr3:176769514ENST00000457928316389_43768515.0RepeatNote=WD 6
TgeneTBL1XR1chr3:45461221chr3:176769514ENST00000457928316440_47968515.0RepeatNote=WD 7
TgeneTBL1XR1chr3:45461221chr3:176769514ENST00000457928316481_51368515.0RepeatNote=WD 8

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLARS2chr3:45461221chr3:176769514ENST00000265537+622639_643172904.0MotifNote='KMSKS' region
HgeneLARS2chr3:45461221chr3:176769514ENST00000415258+521639_643172904.0MotifNote='KMSKS' region
TgeneTBL1XR1chr3:45461221chr3:176769514ENST0000043006931641_8668515.0DomainNote=F-box-like
TgeneTBL1XR1chr3:45461221chr3:176769514ENST000004300693164_3668515.0DomainLisH
TgeneTBL1XR1chr3:45461221chr3:176769514ENST0000045792831641_8668515.0DomainNote=F-box-like
TgeneTBL1XR1chr3:45461221chr3:176769514ENST000004579283164_3668515.0DomainLisH


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Fusion Gene Sequence for LARS2-TBL1XR1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>44167_44167_1_LARS2-TBL1XR1_LARS2_chr3_45461221_ENST00000265537_TBL1XR1_chr3_176769514_ENST00000430069_length(transcript)=8262nt_BP=778nt
GTTGCTCTCCTCCCTTCCCCGGTCCCGCCCCCGTCTGTCTGTGTCGACTGCGGACGCTATCGATAAAGTTGCTGTTTTGACAACATGGCG
GCGCCCATGGTCCGTGGCCCGGCAGTGCTCGCCTAAAGGTGGAGAACGAGGAGTAGAGGAGCCGCAGGCCAGAGCCTGTGAGCAGATCCA
GACCTACAGATAAAAAACATTATTTAATCTATCTGGGATTTACTCCGGCTTATGATTTGAGGGCCTTCTCACCTTCTGAAGAATGGCTTC
TGTTTGGCAGAGATTGGGTTTTTATGCCTCTCTTCTGAAAAGACAGCTAAATGGTGGGCCAGATGTCATCAAGTGGGAAAGGAGAGTAAT
TCCCGGATGTACCAGAAGCATCTACAGTGCCACGGGAAAGTGGACAAAAGAGTATACATTGCAGACAAGAAAGGATGTTGAGAAATGGTG
GCATCAACGAATAAAAGAACAGGCCTCCAAAATTTCAGAAGCTGATAAATCGAAGCCAAAATTTTACGTGCTTTCCATGTTCCCTTATCC
TTCTGGTAAGCTGCACATGGGCCATGTGCGTGTCTACACCATCAGCGACACCATAGCACGGTTCCAGAAGATGAGAGGGATGCAGGTCAT
CAACCCCATGGGATGGGATGCTTTTGGATTGCCTGCTGAAAATGCCGCAGTCGAGAGGAATCTACATCCACAAAGTTGGACACAAAGTAA
TATTAAACACATGAGGAAACAGCTTGATCGTCTGGGCCTGTGTTTCAGCTGGGATAGGGATGGTACCTTGTTTGATGGTCGACCAATAGA
GTCTCTGTCCCTGATAGATGCCGTAATGCCTGATGTAGTACAAACAAGACAACAAGCTTATAGAGATAAGCTTGCACAGCAACAGGCAGC
AGCTGCTGCAGCTGCCGCAGCTGCAGCCAGCCAACAAGGATCTGCAAAAAATGGAGAAAACACAGCAAATGGGGAGGAGAATGGAGCACA
TACTATAGCAAATAATCATACTGATATGATGGAAGTGGATGGGGATGTTGAAATCCCTCCTAATAAAGCTGTTGTGTTGCGGGGCCATGA
ATCTGAAGTTTTTATCTGTGCCTGGAACCCTGTTAGTGATCTCCTAGCATCAGGGTCTGGAGACTCAACAGCAAGAATATGGAATCTTAG
TGAGAACAGCACCAGTGGCTCTACACAGTTAGTACTTAGACATTGTATACGAGAAGGAGGGCAAGATGTTCCAAGCAACAAGGATGTCAC
ATCTCTAGATTGGAATAGTGAAGGTACACTTCTAGCAACTGGTTCCTATGATGGGTTTGCCAGAATATGGACTAAAGATGGTAACCTTGC
TAGCACCTTAGGGCAGCATAAAGGCCCTATATTTGCATTAAAATGGAATAAGAAAGGAAATTTCATCCTAAGTGCTGGAGTAGACAAGAC
TACAATTATTTGGGACGCACATACTGGTGAAGCCAAGCAACAGTTTCCTTTTCATTCAGCACCAGCATTGGATGTTGATTGGCAGAGCAA
CAACACCTTTGCTTCTTGTAGTACAGATATGTGCATTCATGTCTGTAAATTAGGACAAGACAGACCTATTAAAACATTCCAAGGACATAC
GAATGAAGTAAATGCTATCAAATGGGACCCAACTGGCAATCTCTTGGCCTCCTGTTCTGACGACATGACTTTAAAGATATGGAGTATGAA
ACAAGACAATTGTGTCCATGATTTGCAAGCACATAATAAAGAAATTTATACTATCAAATGGAGTCCAACAGGACCAGGGACTAATAATCC
AAATGCCAACCTTATGTTAGCAAGTGCATCCTTTGATTCTACTGTTAGGTTATGGGATGTAGACCGAGGGATATGCATCCATACCTTGAC
AAAACACCAAGAGCCTGTGTACAGTGTAGCTTTCAGTCCTGATGGCAGGTATCTGGCAAGTGGTTCTTTTGACAAATGTGTACACATCTG
GAACACGCAGACAGGTGCTCTAGTTCACAGCTATAGGGGAACAGGTGGAATATTTGAAGTTTGCTGGAATGCAGCAGGAGACAAAGTTGG
AGCCAGTGCATCAGATGGTTCAGTTTGTGTATTAGACCTTCGGAAATAGCGCTACTAGTTGGAAGCCATGGACCGACTATGAATGTGTAC
ATAGCCAAAATGACTGTCCCTGACCCATGTACTGCTATAGTCCCACTTGAACCATGGCCAGTCCACTACAGCCAAATCTAAAAGAAATAT
ATACATACAGTGTATATAAACAAAATTGCACCCTGAAGATGACAGAGTTTTGTCACAGCTTGTGAATTCTGTTCACCAAGTGCTGGAATC
TAATCTGCTGTGCCCCTAAAATAGCATTTAGAAGTTTTGGATATGAAAAACAGAAGAGAGAAAAATATACATTATAAAAGCAGAACATAC
ATGTACCAGTTTTTGGATACTAAATGACAGCCTTGTTTCTCCCCTTTGAATCAGCAGACACCATGGATTATATTCTTTTTTTCCCTTCAG
TAGTGAGCAGTTTGTATGTACAGAGAAAATGGACTTACAAAAACTTGCAGCAGTAGTTTGTTCTTGCTTTAAAATTTCGTTTTTGGTTTA
GATTATGGATGCATGAAGTAAGGGAGTGAATCAGTTTCTTGTTTATATTTTTTTCACCTTTTAAACAAAAAATTCTTTAAAATATTTTAA
TGCATTCTTTTGAAGAGGTAGATGTTTGGTACATTTTATGGCTCCCAGAGCATATATTCAGTTGGTGCATGTTGTGGAAGGGGGAATTGG
AAATTAAATGAAAACCTATGACTTTGGTCATGTCAATCTGTAAGACACATCAGTAAAAGGGTATTATGCTCTGTTGGTTTTGTTTTTTTG
TTTTGCTTTTTTTTTTTTTTTTTCTTTTTTGTTTTTTGGTGATGTGGCTTAAATGCAATAGTTTCTTTTTTGGGACATATTTCTGCCAAT
TAAAGACTAGAAGGGCACAACTTTTTTTTTAATTACCATAGAGAAGATACATTAAAAAAAATCTTCTGATGTTTTGTAGCCATAACTAAA
TTATGGTAAAAATGTGCACTATTGTGAAAAGGAGCAACGTAGTTTTGGGTTTTTTGTTGTTTGTTTGTTTTGCTTTGTTTTTTAAGAGAT
TAAAATGTTTCTGGATAAGGATTAGCTTCTCGAAGTGTCCATCATTCTGTGTAGAAGCTTAAATATGTAATGTAACCAAACTCCAGTATT
AAAAATCTCTCATGTTGTTTTCTTTATACAAAGCAAGATAACGGCATATAACACTGCCATTACATGGCAAAATGTTTGCTACCTTAGTTT
AAAAAACAATCTCAAACAAAAGACTTGCTTCAAGGTGTTTTTAAATAGCAGTGATTCAGAATTTTTTTTAATGAAAGTATAATTGCACTA
ACCTTCTTCCTGCTGCTCTGATTCTGCATTTGTGGTACTTGTGACTACGTTTTTTCAAATATAGATAGATTTAAGCTGCTAATTTTTTTT
TTTTTAGTAATCACTACTATATCATGTCTTTTACTCTGTTTATAATATCAAGTATTTTCTTAAAGATATAGATATTAAACCTTGTGCTCA
TGCAACTTAGAGTAACATATACAGACAAATGATTGCATGAGGCCATGTTTATATGTGTGACTAATAAGGCTTGTCATGATTAACATAATC
CAGGTATGTCATTTCTGAAGAGAATAGTCATCAAATTTATATCTCGAAGATTTTAATTAAGGAATTGCTTATTGTTGAGCTTAGCAAATT
AATAACACTATTTCTGTCACTAATTATTTTGAGGCCTTTTAGTACTAAAATTTTAACCTGTGTTCTAAGTAGAAACTGATTTAACCCAAG
TAATGCAGCTTTGATTGATTTCAGCATTCGTTGCTTTGCTATTTTTACAAAACAGCATTGATTGAAGCAAGTCTTGGTTTTACTAAGGTA
GGGTAGCATTTGCTATTGGTAAAGAGAATAAATACACTTAATTTCACAATACATTGTTATATGTACCCCAGTTGTTGTTAGTGGGGACTA
TGATACTGTAATAATATTTTTAAAAATTTACATCAAGAGAGGCAGTCATTCACGATGGTTTTGTGCCAGCTCTTTTTAGGGTTTTGGATC
ACATTAGAGATATTTAGAACATATTACCCTGTGACTTACGTAGGAAACCTAATATGCTGAGTATCTGGCACTTGAATTCCTGCTTTTATT
GCTGGAGGTCCACATCTGTGGTTGACCTCTGTTATTGTTTAAAAAAAATAAATAAAAATTAAAAAAATCTGTGCAATAATTTTAAAATGT
GCTCCCAGGAATAGACACAAATGTTTTGAGTATCTTTTAAGCTGCATTTTCCTTTAGTGATGCATTTGTCAATTGCACTGAATTTAAATC
TGAAAGTCAGAGGTGATTATTGATAGTACTTTTGTATTTTGATATGGACAGTTTATTCATTTGCATACAGTTATTGACTTTTTCCCAGCT
GATTAAAAGATAGTCAAGAAATTCTGCAATATAGCTGCCAAAATAGACAGCTACATTTTTATGATATTGTCATCTTTTCTGTTTTTTTTT
TCTTTTTTTTCTTTAGCTATTTTACTTAAGCATAATAGCCACAATAGGACATATAAAAGATTATAAATACAGAGCTTTATTATCCTGACG
TCTTGGGTCTTTTAAGTATATACTTTTCTGAAAGGTATCCATTTTGTAGGCTTGGGTTCTTCATGAGCATACGATTGTTTATTTTTGCTG
CTGTTCTCAACATCATCATTGCCTGCTGATGTGCCACGATGCTGCTCCAATAGACAGCAATAAGATTGTCTCTAATTTGAGCAGTAACAT
GATTGCAAGAGACCAAGTTTCACAGCTTGTAAAGTTCTGTATTTGGGATTCTTGCTTATTTTTCCGCCTGTGTTTTTCTGAGAACTTATT
CCTGATGATCAATTGAATCCAGTAGTTTTTCTATGCTATTTGTTGTTGTATAAGCTACTGTAAGAAACTTATCATAAGGAAAAATAGAAA
GGAAAACTTGAATCAATACTCATTGATTAAAATGGAATAAAGAAAGAGCAGCTGCCACTTTTAAACAACATAAAGGAATATCTTTTTTTG
TCTCCGTGTAGGAAATCCCATAAGTTCTTATATTTGTTCCAGTTCCCATTTCCTGCCATTGACCAGATAACATCATTGACTTTCAAATGA
CTTTTAGAAGTGATAACTCTTAATTTCCTAATAGATACTAGATTGTATTGAATTCTGTTTTAATTATTCTCTAGGTAAGTATGTTTTAGG
ATTAAATACCTTTTACAGATACTGAAAGTGCCTCCTTTTGTGGTGTAAAAAACAAATTATGGTGCAAAAAGTAATCACTAGATTGAAATA
CATGAAGGTTTTTTGCTTTTTGACATACGAAAATGTCAAGAGAAAGGCCAAAGATTTGTACTTTTTCACTTACAAAGCACTCCTTTTTCC
CTTAAACTTCTTTCTGTCAAATTAGATTTAATGAGAGAGTACTATTTTTAAGGAGCTATCTGTTTATGTAGAATGATTTTGTTAAGAGTA
ATGTAAACTATTATTGAGTAGAGGCCTAAAGAGGACTGTGCATTTTTGCTATTTAAAGGAATCACAAATGATCATACTTAAGTGAGCAAA
AATGACAAGTTTTACTAGCTAAGTAGAGAAATAAATCTCAAATGCAGCGCTACAATTTTCATTATCTTAAGTACATTGTACATTTCTACA
GAACCTGTGATTATTCTCGCATGATAAGGATGGTACTTGCATATGGTGAATTACTACTGTTGACAGTTTCCGCAGAAATCCTATTTCAGT
GGACCAACATTGTGGCATGGCAGCAAATGCCAACATTTTGTGGAATAGCAGCAAATCTACAAGAGACCCTGGTTGGTTTTTCGTTTTGTT
TTCTTTGTTTTTTCCCCCTTCTCCTGAATCAGCAGGGATGGAAGGAGGGTAGGGAAGTTATGAATTACTCCTTCCAGTAGTAGCTCTGAA
GTGTCACATTTAATATCAGTTTTTTTTAAACATGATTCTAGTTAAATGTAGAAGAGAGAAGAAAGAGGAAGTGTTCACTTTTTTAATACA
CTGATTTAGAAATTTGATGTCTTATATCAGTAGTTCTGAGGTATTGATAGCTTGCTTTATTTCTGCCTTTACGTTGACAGTGTTGAAGCA
GGGTGAATAACTAGGGCATATATTTTTTTTTTTTTTGTAAGCTGTTTCATGATGTTTTCTTTGGAATTTCCGGATAAGTTCAGGAAAACA
TTCTGCATGTTGTATCTAGTCTGATGTACTTATCCATCTCATTACAAACAAAAACACACAGACTGCATTTGTAGCTCTGTAATCCTTGAA
TACGGAAGTAAATTTTCTTCTTTCCTGACTTTGACATTGTAGCTATACTGTTTCCATTTTTGTTTTTACAAATCCTTTGGGTCTAATTCT
GTGAGCCTACCTATAGCACTGGATTAAAATGTCTGCATCATTTCTTTAGTTATCCAGTTAACTTTAAAACTGTTGTAAAAGTGTAAACCA
GCCCATGACAGGTTTTTGTACATGTTAAAGAACTTCATTGTTCAGTTTTCATGATTATTGTGTAAGGAAGACTGATGTAGATGTTCTGTG
CTGTCCTGGACCATGTTAATTACACTTACGACGTATTTTAGTTCCACATCACAATGATTTGTCCCCAGTGACCCTTTTATCCTTTCTAGG
CACATTTCTTGTTGTTGTTGTTGTTGCAGTTCCCCTTTGCATTGTATTGCTTTGACAACTGTAATTTGAATCAGATCTGAAAGAGGTCCA
GAATAAAATATATTTTGATATTATGTTGGCTGTGTACATATATAAAACCTTTGATGTCTATGTAGTTTATATAGACTATTTACTAGTCAG
GTAAAGAGAGAGGGATGGTATTTCTTGTTTACAGTTTGTTTACATTTTAATTGCTTTTACTTCTCCAGTGTTCTATTGTAGAATAAACCT
TTTTTTCCAAGTTAGCCTTCATAACCTATAACACATTCATTCTCTCCCATACTGGTGTTACTGATTAATAACTGCCATCAGAACCCAAAC
CACTGTTTTTCATAAACGTATTGTTTCCCAAGATATATACTTTAAGCCCATAATAAAATTACAAATTTTACTATTTTTATTACTTCTTGC
AGGAGATAAGATTTTTTTAAATGAAGGGGTTATTTACTATTTTTATTAAAGTATAATAGAGCATCTAATCAGCTAAGGGATTGTAATTTT
TAATTCTTTTGAAAAATAAATATTGTATTTAAAAGACGTTATTTCACAGAAGCTGAAAAAGAGACCTTAGATAACATTTGTTTGGTTAGC
CACACGGTTGAGCACAAAACAATGTGTAGATGTGTTGAAGATTAGGGCAGGAGGCTCAACTTCTCGGTGACCTTTTTTTGCTTCACAACA
AGCCAATTATAGTTGAATCATTTTCTCTCTTAGCTAGTTGTTACTACAAACTTTATAAGAAAAACAACTAGACACCTTCTAGTTTTAATT
AATACCAACTCCTTTAGAGTTAGAGACTTTTTAAAAAGAATCATTGAGCATATTTTCTTTTTTTTTTTTTTAAGAATTTACACTCTCTAG
GTCTTCTATTTTTCCTGTTTATTTCCTTAAACAGAAATAAATTCAAGCATAGTTTTATGTTTTATTAGAAATAAGCCACTGCAGTTGCTA
GAACTGACATGCTTTCATTTTCAAGGGGTTAACTTTTATTGCATGGCATAGATTATTAGTAATATCCTGCATTGTATACTTTTCCAAAAA
GGGTTGGACTCCTAAGGATTAGAATCCTTATAAGCTTGAGGGAAAGCTGAAACTAATTTGAACAGTAATAGAAGGGATTATTTTTAATTT
CATAGTTAACACTTTACAATGGATTAGATTTATTACCTAGTATAATCCGTAGCAGATCAGATCAAAGTTTACTGTTTTACCAATATATTC
ATTTGAAAAAATACAGTGGAGGAAAAGACACTTTAGATGGTAGTTTTATGGTGCTTTTCTCTGCTGTACCAAAGTGCTTTGTCATCAATG
AAATGTTAACCCTATGCTACTTTTTCTGCATGCTTCTTAAATGTCATCTTAATGCTTAATTGTCCTAACTTGTAATATTTTTGTATTAAA

>44167_44167_1_LARS2-TBL1XR1_LARS2_chr3_45461221_ENST00000265537_TBL1XR1_chr3_176769514_ENST00000430069_length(amino acids)=618AA_BP=172
MASVWQRLGFYASLLKRQLNGGPDVIKWERRVIPGCTRSIYSATGKWTKEYTLQTRKDVEKWWHQRIKEQASKISEADKSKPKFYVLSMF
PYPSGKLHMGHVRVYTISDTIARFQKMRGMQVINPMGWDAFGLPAENAAVERNLHPQSWTQSNIKHMRKQLDRLGLCFSWDRDGTLFDGR
PIESLSLIDAVMPDVVQTRQQAYRDKLAQQQAAAAAAAAAAASQQGSAKNGENTANGEENGAHTIANNHTDMMEVDGDVEIPPNKAVVLR
GHESEVFICAWNPVSDLLASGSGDSTARIWNLSENSTSGSTQLVLRHCIREGGQDVPSNKDVTSLDWNSEGTLLATGSYDGFARIWTKDG
NLASTLGQHKGPIFALKWNKKGNFILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQSNNTFASCSTDMCIHVCKLGQDRPIKTFQ
GHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKEIYTIKWSPTGPGTNNPNANLMLASASFDSTVRLWDVDRGICIH

--------------------------------------------------------------
>44167_44167_2_LARS2-TBL1XR1_LARS2_chr3_45461221_ENST00000265537_TBL1XR1_chr3_176769514_ENST00000457928_length(transcript)=4297nt_BP=778nt
GTTGCTCTCCTCCCTTCCCCGGTCCCGCCCCCGTCTGTCTGTGTCGACTGCGGACGCTATCGATAAAGTTGCTGTTTTGACAACATGGCG
GCGCCCATGGTCCGTGGCCCGGCAGTGCTCGCCTAAAGGTGGAGAACGAGGAGTAGAGGAGCCGCAGGCCAGAGCCTGTGAGCAGATCCA
GACCTACAGATAAAAAACATTATTTAATCTATCTGGGATTTACTCCGGCTTATGATTTGAGGGCCTTCTCACCTTCTGAAGAATGGCTTC
TGTTTGGCAGAGATTGGGTTTTTATGCCTCTCTTCTGAAAAGACAGCTAAATGGTGGGCCAGATGTCATCAAGTGGGAAAGGAGAGTAAT
TCCCGGATGTACCAGAAGCATCTACAGTGCCACGGGAAAGTGGACAAAAGAGTATACATTGCAGACAAGAAAGGATGTTGAGAAATGGTG
GCATCAACGAATAAAAGAACAGGCCTCCAAAATTTCAGAAGCTGATAAATCGAAGCCAAAATTTTACGTGCTTTCCATGTTCCCTTATCC
TTCTGGTAAGCTGCACATGGGCCATGTGCGTGTCTACACCATCAGCGACACCATAGCACGGTTCCAGAAGATGAGAGGGATGCAGGTCAT
CAACCCCATGGGATGGGATGCTTTTGGATTGCCTGCTGAAAATGCCGCAGTCGAGAGGAATCTACATCCACAAAGTTGGACACAAAGTAA
TATTAAACACATGAGGAAACAGCTTGATCGTCTGGGCCTGTGTTTCAGCTGGGATAGGGATGGTACCTTGTTTGATGGTCGACCAATAGA
GTCTCTGTCCCTGATAGATGCCGTAATGCCTGATGTAGTACAAACAAGACAACAAGCTTATAGAGATAAGCTTGCACAGCAACAGGCAGC
AGCTGCTGCAGCTGCCGCAGCTGCAGCCAGCCAACAAGGATCTGCAAAAAATGGAGAAAACACAGCAAATGGGGAGGAGAATGGAGCACA
TACTATAGCAAATAATCATACTGATATGATGGAAGTGGATGGGGATGTTGAAATCCCTCCTAATAAAGCTGTTGTGTTGCGGGGCCATGA
ATCTGAAGTTTTTATCTGTGCCTGGAACCCTGTTAGTGATCTCCTAGCATCAGGGTCTGGAGACTCAACAGCAAGAATATGGAATCTTAG
TGAGAACAGCACCAGTGGCTCTACACAGTTAGTACTTAGACATTGTATACGAGAAGGAGGGCAAGATGTTCCAAGCAACAAGGATGTCAC
ATCTCTAGATTGGAATAGTGAAGGTACACTTCTAGCAACTGGTTCCTATGATGGGTTTGCCAGAATATGGACTAAAGATGGTAACCTTGC
TAGCACCTTAGGGCAGCATAAAGGCCCTATATTTGCATTAAAATGGAATAAGAAAGGAAATTTCATCCTAAGTGCTGGAGTAGACAAGAC
TACAATTATTTGGGACGCACATACTGGTGAAGCCAAGCAACAGTTTCCTTTTCATTCAGCACCAGCATTGGATGTTGATTGGCAGAGCAA
CAACACCTTTGCTTCTTGTAGTACAGATATGTGCATTCATGTCTGTAAATTAGGACAAGACAGACCTATTAAAACATTCCAAGGACATAC
GAATGAAGTAAATGCTATCAAATGGGACCCAACTGGCAATCTCTTGGCCTCCTGTTCTGACGACATGACTTTAAAGATATGGAGTATGAA
ACAAGACAATTGTGTCCATGATTTGCAAGCACATAATAAAGAAATTTATACTATCAAATGGAGTCCAACAGGACCAGGGACTAATAATCC
AAATGCCAACCTTATGTTAGCAAGTGCATCCTTTGATTCTACTGTTAGGTTATGGGATGTAGACCGAGGGATATGCATCCATACCTTGAC
AAAACACCAAGAGCCTGTGTACAGTGTAGCTTTCAGTCCTGATGGCAGGTATCTGGCAAGTGGTTCTTTTGACAAATGTGTACACATCTG
GAACACGCAGACAGGTGCTCTAGTTCACAGCTATAGGGGAACAGGTGGAATATTTGAAGTTTGCTGGAATGCAGCAGGAGACAAAGTTGG
AGCCAGTGCATCAGATGGTTCAGTTTGTGTATTAGACCTTCGGAAATAGCGCTACTAGTTGGAAGCCATGGACCGACTATGAATGTGTAC
ATAGCCAAAATGACTGTCCCTGACCCATGTACTGCTATAGTCCCACTTGAACCATGGCCAGTCCACTACAGCCAAATCTAAAAGAAATAT
ATACATACAGTGTATATAAACAAAATTGCACCCTGAAGATGACAGAGTTTTGTCACAGCTTGTGAATTCTGTTCACCAAGTGCTGGAATC
TAATCTGCTGTGCCCCTAAAATAGCATTTAGAAGTTTTGGATATGAAAAACAGAAGAGAGAAAAATATACATTATAAAAGCAGAACATAC
ATGTACCAGTTTTTGGATACTAAATGACAGCCTTGTTTCTCCCCTTTGAATCAGCAGACACCATGGATTATATTCTTTTTTTCCCTTCAG
TAGTGAGCAGTTTGTATGTACAGAGAAAATGGACTTACAAAAACTTGCAGCAGTAGTTTGTTCTTGCTTTAAAATTTCGTTTTTGGTTTA
GATTATGGATGCATGAAGTAAGGGAGTGAATCAGTTTCTTGTTTATATTTTTTTCACCTTTTAAACAAAAAATTCTTTAAAATATTTTAA
TGCATTCTTTTGAAGAGGTAGATGTTTGGTACATTTTATGGCTCCCAGAGCATATATTCAGTTGGTGCATGTTGTGGAAGGGGGAATTGG
AAATTAAATGAAAACCTATGACTTTGGTCATGTCAATCTGTAAGACACATCAGTAAAAGGGTATTATGCTCTGTTGGTTTTGTTTTTTTG
TTTTGCTTTTTTTTTTTTTTTTTCTTTTTTGTTTTTTGGTGATGTGGCTTAAATGCAATAGTTTCTTTTTTGGGACATATTTCTGCCAAT
TAAAGACTAGAAGGGCACAACTTTTTTTTTAATTACCATAGAGAAGATACATTAAAAAAAATCTTCTGATGTTTTGTAGCCATAACTAAA
TTATGGTAAAAATGTGCACTATTGTGAAAAGGAGCAACGTAGTTTTGGGTTTTTTGTTGTTTGTTTGTTTTGCTTTGTTTTTTAAGAGAT
TAAAATGTTTCTGGATAAGGATTAGCTTCTCGAAGTGTCCATCATTCTGTGTAGAAGCTTAAATATGTAATGTAACCAAACTCCAGTATT
AAAAATCTCTCATGTTGTTTTCTTTATACAAAGCAAGATAACGGCATATAACACTGCCATTACATGGCAAAATGTTTGCTACCTTAGTTT
AAAAAACAATCTCAAACAAAAGACTTGCTTCAAGGTGTTTTTAAATAGCAGTGATTCAGAATTTTTTTTAATGAAAGTATAATTGCACTA
ACCTTCTTCCTGCTGCTCTGATTCTGCATTTGTGGTACTTGTGACTACGTTTTTTCAAATATAGATAGATTTAAGCTGCTAATTTTTTTT
TTTTTAGTAATCACTACTATATCATGTCTTTTACTCTGTTTATAATATCAAGTATTTTCTTAAAGATATAGATATTAAACCTTGTGCTCA
TGCAACTTAGAGTAACATATACAGACAAATGATTGCATGAGGCCATGTTTATATGTGTGACTAATAAGGCTTGTCATGATTAACATAATC
CAGGTATGTCATTTCTGAAGAGAATAGTCATCAAATTTATATCTCGAAGATTTTAATTAAGGAATTGCTTATTGTTGAGCTTAGCAAATT
AATAACACTATTTCTGTCACTAATTATTTTGAGGCCTTTTAGTACTAAAATTTTAACCTGTGTTCTAAGTAGAAACTGATTTAACCCAAG
TAATGCAGCTTTGATTGATTTCAGCATTCGTTGCTTTGCTATTTTTACAAAACAGCATTGATTGAAGCAAGTCTTGGTTTTACTAAGGTA
GGGTAGCATTTGCTATTGGTAAAGAGAATAAATACACTTAATTTCACAATACATTGTTATATGTACCCCAGTTGTTGTTAGTGGGGACTA
TGATACTGTAATAATATTTTTAAAAATTTACATCAAGAGAGGCAGTCATTCACGATGGTTTTGTGCCAGCTCTTTTTAGGGTTTTGGATC
ACATTAGAGATATTTAGAACATATTACCCTGTGACTTACGTAGGAAACCTAATATGCTGAGTATCTGGCACTTGAATTCCTGCTTTTATT

>44167_44167_2_LARS2-TBL1XR1_LARS2_chr3_45461221_ENST00000265537_TBL1XR1_chr3_176769514_ENST00000457928_length(amino acids)=618AA_BP=172
MASVWQRLGFYASLLKRQLNGGPDVIKWERRVIPGCTRSIYSATGKWTKEYTLQTRKDVEKWWHQRIKEQASKISEADKSKPKFYVLSMF
PYPSGKLHMGHVRVYTISDTIARFQKMRGMQVINPMGWDAFGLPAENAAVERNLHPQSWTQSNIKHMRKQLDRLGLCFSWDRDGTLFDGR
PIESLSLIDAVMPDVVQTRQQAYRDKLAQQQAAAAAAAAAAASQQGSAKNGENTANGEENGAHTIANNHTDMMEVDGDVEIPPNKAVVLR
GHESEVFICAWNPVSDLLASGSGDSTARIWNLSENSTSGSTQLVLRHCIREGGQDVPSNKDVTSLDWNSEGTLLATGSYDGFARIWTKDG
NLASTLGQHKGPIFALKWNKKGNFILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQSNNTFASCSTDMCIHVCKLGQDRPIKTFQ
GHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKEIYTIKWSPTGPGTNNPNANLMLASASFDSTVRLWDVDRGICIH

--------------------------------------------------------------
>44167_44167_3_LARS2-TBL1XR1_LARS2_chr3_45461221_ENST00000414984_TBL1XR1_chr3_176769514_ENST00000430069_length(transcript)=8009nt_BP=525nt
ATCGATAAAGTTGCTGTTTTGACAACATGGCGGCGCCCATGGTCCGTGGCCCGGCAGTGCTCGCCTAAAGGTGGAGAACGAGGAGTAGAG
GAGCCGCAGGCCAGAGCCTGTGAGCAGGGCCTTCTCACCTTCTGAAGAATGGCTTCTGTTTGGCAGAGATTGGGTTTTTATGCCTCTCTT
CTGAAAAGACAGCTAAATGGTGGGCCAGATGTCATCAAGTGGGAAAGGAGAGTAATTCCCGGATGTACCAGAAGCATCTACAGTGCCACG
GGAAAGTGGACAAAAGAGTATACATTGCAGACAAGAAAGGATGTTGAGAAATGGTGGCATCAACGAATAAAAGAACAGGCCTCCAAAATT
TCAGAAGCTGATGTCATCAACCCCATGGGATGGGATGCTTTTGGATTGCCTGCTGAAAATGCCGCAGTCGAGAGGAATCTACATCCACAA
AGTTGGACACAAAGTAATATTAAACACATGAGGAAACAGCTTGATCGTCTGGGCCTGTGTTTCAGCTGGGATAGGGATGGTACCTTGTTT
GATGGTCGACCAATAGAGTCTCTGTCCCTGATAGATGCCGTAATGCCTGATGTAGTACAAACAAGACAACAAGCTTATAGAGATAAGCTT
GCACAGCAACAGGCAGCAGCTGCTGCAGCTGCCGCAGCTGCAGCCAGCCAACAAGGATCTGCAAAAAATGGAGAAAACACAGCAAATGGG
GAGGAGAATGGAGCACATACTATAGCAAATAATCATACTGATATGATGGAAGTGGATGGGGATGTTGAAATCCCTCCTAATAAAGCTGTT
GTGTTGCGGGGCCATGAATCTGAAGTTTTTATCTGTGCCTGGAACCCTGTTAGTGATCTCCTAGCATCAGGGTCTGGAGACTCAACAGCA
AGAATATGGAATCTTAGTGAGAACAGCACCAGTGGCTCTACACAGTTAGTACTTAGACATTGTATACGAGAAGGAGGGCAAGATGTTCCA
AGCAACAAGGATGTCACATCTCTAGATTGGAATAGTGAAGGTACACTTCTAGCAACTGGTTCCTATGATGGGTTTGCCAGAATATGGACT
AAAGATGGTAACCTTGCTAGCACCTTAGGGCAGCATAAAGGCCCTATATTTGCATTAAAATGGAATAAGAAAGGAAATTTCATCCTAAGT
GCTGGAGTAGACAAGACTACAATTATTTGGGACGCACATACTGGTGAAGCCAAGCAACAGTTTCCTTTTCATTCAGCACCAGCATTGGAT
GTTGATTGGCAGAGCAACAACACCTTTGCTTCTTGTAGTACAGATATGTGCATTCATGTCTGTAAATTAGGACAAGACAGACCTATTAAA
ACATTCCAAGGACATACGAATGAAGTAAATGCTATCAAATGGGACCCAACTGGCAATCTCTTGGCCTCCTGTTCTGACGACATGACTTTA
AAGATATGGAGTATGAAACAAGACAATTGTGTCCATGATTTGCAAGCACATAATAAAGAAATTTATACTATCAAATGGAGTCCAACAGGA
CCAGGGACTAATAATCCAAATGCCAACCTTATGTTAGCAAGTGCATCCTTTGATTCTACTGTTAGGTTATGGGATGTAGACCGAGGGATA
TGCATCCATACCTTGACAAAACACCAAGAGCCTGTGTACAGTGTAGCTTTCAGTCCTGATGGCAGGTATCTGGCAAGTGGTTCTTTTGAC
AAATGTGTACACATCTGGAACACGCAGACAGGTGCTCTAGTTCACAGCTATAGGGGAACAGGTGGAATATTTGAAGTTTGCTGGAATGCA
GCAGGAGACAAAGTTGGAGCCAGTGCATCAGATGGTTCAGTTTGTGTATTAGACCTTCGGAAATAGCGCTACTAGTTGGAAGCCATGGAC
CGACTATGAATGTGTACATAGCCAAAATGACTGTCCCTGACCCATGTACTGCTATAGTCCCACTTGAACCATGGCCAGTCCACTACAGCC
AAATCTAAAAGAAATATATACATACAGTGTATATAAACAAAATTGCACCCTGAAGATGACAGAGTTTTGTCACAGCTTGTGAATTCTGTT
CACCAAGTGCTGGAATCTAATCTGCTGTGCCCCTAAAATAGCATTTAGAAGTTTTGGATATGAAAAACAGAAGAGAGAAAAATATACATT
ATAAAAGCAGAACATACATGTACCAGTTTTTGGATACTAAATGACAGCCTTGTTTCTCCCCTTTGAATCAGCAGACACCATGGATTATAT
TCTTTTTTTCCCTTCAGTAGTGAGCAGTTTGTATGTACAGAGAAAATGGACTTACAAAAACTTGCAGCAGTAGTTTGTTCTTGCTTTAAA
ATTTCGTTTTTGGTTTAGATTATGGATGCATGAAGTAAGGGAGTGAATCAGTTTCTTGTTTATATTTTTTTCACCTTTTAAACAAAAAAT
TCTTTAAAATATTTTAATGCATTCTTTTGAAGAGGTAGATGTTTGGTACATTTTATGGCTCCCAGAGCATATATTCAGTTGGTGCATGTT
GTGGAAGGGGGAATTGGAAATTAAATGAAAACCTATGACTTTGGTCATGTCAATCTGTAAGACACATCAGTAAAAGGGTATTATGCTCTG
TTGGTTTTGTTTTTTTGTTTTGCTTTTTTTTTTTTTTTTTCTTTTTTGTTTTTTGGTGATGTGGCTTAAATGCAATAGTTTCTTTTTTGG
GACATATTTCTGCCAATTAAAGACTAGAAGGGCACAACTTTTTTTTTAATTACCATAGAGAAGATACATTAAAAAAAATCTTCTGATGTT
TTGTAGCCATAACTAAATTATGGTAAAAATGTGCACTATTGTGAAAAGGAGCAACGTAGTTTTGGGTTTTTTGTTGTTTGTTTGTTTTGC
TTTGTTTTTTAAGAGATTAAAATGTTTCTGGATAAGGATTAGCTTCTCGAAGTGTCCATCATTCTGTGTAGAAGCTTAAATATGTAATGT
AACCAAACTCCAGTATTAAAAATCTCTCATGTTGTTTTCTTTATACAAAGCAAGATAACGGCATATAACACTGCCATTACATGGCAAAAT
GTTTGCTACCTTAGTTTAAAAAACAATCTCAAACAAAAGACTTGCTTCAAGGTGTTTTTAAATAGCAGTGATTCAGAATTTTTTTTAATG
AAAGTATAATTGCACTAACCTTCTTCCTGCTGCTCTGATTCTGCATTTGTGGTACTTGTGACTACGTTTTTTCAAATATAGATAGATTTA
AGCTGCTAATTTTTTTTTTTTTAGTAATCACTACTATATCATGTCTTTTACTCTGTTTATAATATCAAGTATTTTCTTAAAGATATAGAT
ATTAAACCTTGTGCTCATGCAACTTAGAGTAACATATACAGACAAATGATTGCATGAGGCCATGTTTATATGTGTGACTAATAAGGCTTG
TCATGATTAACATAATCCAGGTATGTCATTTCTGAAGAGAATAGTCATCAAATTTATATCTCGAAGATTTTAATTAAGGAATTGCTTATT
GTTGAGCTTAGCAAATTAATAACACTATTTCTGTCACTAATTATTTTGAGGCCTTTTAGTACTAAAATTTTAACCTGTGTTCTAAGTAGA
AACTGATTTAACCCAAGTAATGCAGCTTTGATTGATTTCAGCATTCGTTGCTTTGCTATTTTTACAAAACAGCATTGATTGAAGCAAGTC
TTGGTTTTACTAAGGTAGGGTAGCATTTGCTATTGGTAAAGAGAATAAATACACTTAATTTCACAATACATTGTTATATGTACCCCAGTT
GTTGTTAGTGGGGACTATGATACTGTAATAATATTTTTAAAAATTTACATCAAGAGAGGCAGTCATTCACGATGGTTTTGTGCCAGCTCT
TTTTAGGGTTTTGGATCACATTAGAGATATTTAGAACATATTACCCTGTGACTTACGTAGGAAACCTAATATGCTGAGTATCTGGCACTT
GAATTCCTGCTTTTATTGCTGGAGGTCCACATCTGTGGTTGACCTCTGTTATTGTTTAAAAAAAATAAATAAAAATTAAAAAAATCTGTG
CAATAATTTTAAAATGTGCTCCCAGGAATAGACACAAATGTTTTGAGTATCTTTTAAGCTGCATTTTCCTTTAGTGATGCATTTGTCAAT
TGCACTGAATTTAAATCTGAAAGTCAGAGGTGATTATTGATAGTACTTTTGTATTTTGATATGGACAGTTTATTCATTTGCATACAGTTA
TTGACTTTTTCCCAGCTGATTAAAAGATAGTCAAGAAATTCTGCAATATAGCTGCCAAAATAGACAGCTACATTTTTATGATATTGTCAT
CTTTTCTGTTTTTTTTTTCTTTTTTTTCTTTAGCTATTTTACTTAAGCATAATAGCCACAATAGGACATATAAAAGATTATAAATACAGA
GCTTTATTATCCTGACGTCTTGGGTCTTTTAAGTATATACTTTTCTGAAAGGTATCCATTTTGTAGGCTTGGGTTCTTCATGAGCATACG
ATTGTTTATTTTTGCTGCTGTTCTCAACATCATCATTGCCTGCTGATGTGCCACGATGCTGCTCCAATAGACAGCAATAAGATTGTCTCT
AATTTGAGCAGTAACATGATTGCAAGAGACCAAGTTTCACAGCTTGTAAAGTTCTGTATTTGGGATTCTTGCTTATTTTTCCGCCTGTGT
TTTTCTGAGAACTTATTCCTGATGATCAATTGAATCCAGTAGTTTTTCTATGCTATTTGTTGTTGTATAAGCTACTGTAAGAAACTTATC
ATAAGGAAAAATAGAAAGGAAAACTTGAATCAATACTCATTGATTAAAATGGAATAAAGAAAGAGCAGCTGCCACTTTTAAACAACATAA
AGGAATATCTTTTTTTGTCTCCGTGTAGGAAATCCCATAAGTTCTTATATTTGTTCCAGTTCCCATTTCCTGCCATTGACCAGATAACAT
CATTGACTTTCAAATGACTTTTAGAAGTGATAACTCTTAATTTCCTAATAGATACTAGATTGTATTGAATTCTGTTTTAATTATTCTCTA
GGTAAGTATGTTTTAGGATTAAATACCTTTTACAGATACTGAAAGTGCCTCCTTTTGTGGTGTAAAAAACAAATTATGGTGCAAAAAGTA
ATCACTAGATTGAAATACATGAAGGTTTTTTGCTTTTTGACATACGAAAATGTCAAGAGAAAGGCCAAAGATTTGTACTTTTTCACTTAC
AAAGCACTCCTTTTTCCCTTAAACTTCTTTCTGTCAAATTAGATTTAATGAGAGAGTACTATTTTTAAGGAGCTATCTGTTTATGTAGAA
TGATTTTGTTAAGAGTAATGTAAACTATTATTGAGTAGAGGCCTAAAGAGGACTGTGCATTTTTGCTATTTAAAGGAATCACAAATGATC
ATACTTAAGTGAGCAAAAATGACAAGTTTTACTAGCTAAGTAGAGAAATAAATCTCAAATGCAGCGCTACAATTTTCATTATCTTAAGTA
CATTGTACATTTCTACAGAACCTGTGATTATTCTCGCATGATAAGGATGGTACTTGCATATGGTGAATTACTACTGTTGACAGTTTCCGC
AGAAATCCTATTTCAGTGGACCAACATTGTGGCATGGCAGCAAATGCCAACATTTTGTGGAATAGCAGCAAATCTACAAGAGACCCTGGT
TGGTTTTTCGTTTTGTTTTCTTTGTTTTTTCCCCCTTCTCCTGAATCAGCAGGGATGGAAGGAGGGTAGGGAAGTTATGAATTACTCCTT
CCAGTAGTAGCTCTGAAGTGTCACATTTAATATCAGTTTTTTTTAAACATGATTCTAGTTAAATGTAGAAGAGAGAAGAAAGAGGAAGTG
TTCACTTTTTTAATACACTGATTTAGAAATTTGATGTCTTATATCAGTAGTTCTGAGGTATTGATAGCTTGCTTTATTTCTGCCTTTACG
TTGACAGTGTTGAAGCAGGGTGAATAACTAGGGCATATATTTTTTTTTTTTTTGTAAGCTGTTTCATGATGTTTTCTTTGGAATTTCCGG
ATAAGTTCAGGAAAACATTCTGCATGTTGTATCTAGTCTGATGTACTTATCCATCTCATTACAAACAAAAACACACAGACTGCATTTGTA
GCTCTGTAATCCTTGAATACGGAAGTAAATTTTCTTCTTTCCTGACTTTGACATTGTAGCTATACTGTTTCCATTTTTGTTTTTACAAAT
CCTTTGGGTCTAATTCTGTGAGCCTACCTATAGCACTGGATTAAAATGTCTGCATCATTTCTTTAGTTATCCAGTTAACTTTAAAACTGT
TGTAAAAGTGTAAACCAGCCCATGACAGGTTTTTGTACATGTTAAAGAACTTCATTGTTCAGTTTTCATGATTATTGTGTAAGGAAGACT
GATGTAGATGTTCTGTGCTGTCCTGGACCATGTTAATTACACTTACGACGTATTTTAGTTCCACATCACAATGATTTGTCCCCAGTGACC
CTTTTATCCTTTCTAGGCACATTTCTTGTTGTTGTTGTTGTTGCAGTTCCCCTTTGCATTGTATTGCTTTGACAACTGTAATTTGAATCA
GATCTGAAAGAGGTCCAGAATAAAATATATTTTGATATTATGTTGGCTGTGTACATATATAAAACCTTTGATGTCTATGTAGTTTATATA
GACTATTTACTAGTCAGGTAAAGAGAGAGGGATGGTATTTCTTGTTTACAGTTTGTTTACATTTTAATTGCTTTTACTTCTCCAGTGTTC
TATTGTAGAATAAACCTTTTTTTCCAAGTTAGCCTTCATAACCTATAACACATTCATTCTCTCCCATACTGGTGTTACTGATTAATAACT
GCCATCAGAACCCAAACCACTGTTTTTCATAAACGTATTGTTTCCCAAGATATATACTTTAAGCCCATAATAAAATTACAAATTTTACTA
TTTTTATTACTTCTTGCAGGAGATAAGATTTTTTTAAATGAAGGGGTTATTTACTATTTTTATTAAAGTATAATAGAGCATCTAATCAGC
TAAGGGATTGTAATTTTTAATTCTTTTGAAAAATAAATATTGTATTTAAAAGACGTTATTTCACAGAAGCTGAAAAAGAGACCTTAGATA
ACATTTGTTTGGTTAGCCACACGGTTGAGCACAAAACAATGTGTAGATGTGTTGAAGATTAGGGCAGGAGGCTCAACTTCTCGGTGACCT
TTTTTTGCTTCACAACAAGCCAATTATAGTTGAATCATTTTCTCTCTTAGCTAGTTGTTACTACAAACTTTATAAGAAAAACAACTAGAC
ACCTTCTAGTTTTAATTAATACCAACTCCTTTAGAGTTAGAGACTTTTTAAAAAGAATCATTGAGCATATTTTCTTTTTTTTTTTTTTAA
GAATTTACACTCTCTAGGTCTTCTATTTTTCCTGTTTATTTCCTTAAACAGAAATAAATTCAAGCATAGTTTTATGTTTTATTAGAAATA
AGCCACTGCAGTTGCTAGAACTGACATGCTTTCATTTTCAAGGGGTTAACTTTTATTGCATGGCATAGATTATTAGTAATATCCTGCATT
GTATACTTTTCCAAAAAGGGTTGGACTCCTAAGGATTAGAATCCTTATAAGCTTGAGGGAAAGCTGAAACTAATTTGAACAGTAATAGAA
GGGATTATTTTTAATTTCATAGTTAACACTTTACAATGGATTAGATTTATTACCTAGTATAATCCGTAGCAGATCAGATCAAAGTTTACT
GTTTTACCAATATATTCATTTGAAAAAATACAGTGGAGGAAAAGACACTTTAGATGGTAGTTTTATGGTGCTTTTCTCTGCTGTACCAAA
GTGCTTTGTCATCAATGAAATGTTAACCCTATGCTACTTTTTCTGCATGCTTCTTAAATGTCATCTTAATGCTTAATTGTCCTAACTTGT

>44167_44167_3_LARS2-TBL1XR1_LARS2_chr3_45461221_ENST00000414984_TBL1XR1_chr3_176769514_ENST00000430069_length(amino acids)=575AA_BP=129
MASVWQRLGFYASLLKRQLNGGPDVIKWERRVIPGCTRSIYSATGKWTKEYTLQTRKDVEKWWHQRIKEQASKISEADVINPMGWDAFGL
PAENAAVERNLHPQSWTQSNIKHMRKQLDRLGLCFSWDRDGTLFDGRPIESLSLIDAVMPDVVQTRQQAYRDKLAQQQAAAAAAAAAAAS
QQGSAKNGENTANGEENGAHTIANNHTDMMEVDGDVEIPPNKAVVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLSENSTSGSTQL
VLRHCIREGGQDVPSNKDVTSLDWNSEGTLLATGSYDGFARIWTKDGNLASTLGQHKGPIFALKWNKKGNFILSAGVDKTTIIWDAHTGE
AKQQFPFHSAPALDVDWQSNNTFASCSTDMCIHVCKLGQDRPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQA
HNKEIYTIKWSPTGPGTNNPNANLMLASASFDSTVRLWDVDRGICIHTLTKHQEPVYSVAFSPDGRYLASGSFDKCVHIWNTQTGALVHS

--------------------------------------------------------------
>44167_44167_4_LARS2-TBL1XR1_LARS2_chr3_45461221_ENST00000414984_TBL1XR1_chr3_176769514_ENST00000457928_length(transcript)=4044nt_BP=525nt
ATCGATAAAGTTGCTGTTTTGACAACATGGCGGCGCCCATGGTCCGTGGCCCGGCAGTGCTCGCCTAAAGGTGGAGAACGAGGAGTAGAG
GAGCCGCAGGCCAGAGCCTGTGAGCAGGGCCTTCTCACCTTCTGAAGAATGGCTTCTGTTTGGCAGAGATTGGGTTTTTATGCCTCTCTT
CTGAAAAGACAGCTAAATGGTGGGCCAGATGTCATCAAGTGGGAAAGGAGAGTAATTCCCGGATGTACCAGAAGCATCTACAGTGCCACG
GGAAAGTGGACAAAAGAGTATACATTGCAGACAAGAAAGGATGTTGAGAAATGGTGGCATCAACGAATAAAAGAACAGGCCTCCAAAATT
TCAGAAGCTGATGTCATCAACCCCATGGGATGGGATGCTTTTGGATTGCCTGCTGAAAATGCCGCAGTCGAGAGGAATCTACATCCACAA
AGTTGGACACAAAGTAATATTAAACACATGAGGAAACAGCTTGATCGTCTGGGCCTGTGTTTCAGCTGGGATAGGGATGGTACCTTGTTT
GATGGTCGACCAATAGAGTCTCTGTCCCTGATAGATGCCGTAATGCCTGATGTAGTACAAACAAGACAACAAGCTTATAGAGATAAGCTT
GCACAGCAACAGGCAGCAGCTGCTGCAGCTGCCGCAGCTGCAGCCAGCCAACAAGGATCTGCAAAAAATGGAGAAAACACAGCAAATGGG
GAGGAGAATGGAGCACATACTATAGCAAATAATCATACTGATATGATGGAAGTGGATGGGGATGTTGAAATCCCTCCTAATAAAGCTGTT
GTGTTGCGGGGCCATGAATCTGAAGTTTTTATCTGTGCCTGGAACCCTGTTAGTGATCTCCTAGCATCAGGGTCTGGAGACTCAACAGCA
AGAATATGGAATCTTAGTGAGAACAGCACCAGTGGCTCTACACAGTTAGTACTTAGACATTGTATACGAGAAGGAGGGCAAGATGTTCCA
AGCAACAAGGATGTCACATCTCTAGATTGGAATAGTGAAGGTACACTTCTAGCAACTGGTTCCTATGATGGGTTTGCCAGAATATGGACT
AAAGATGGTAACCTTGCTAGCACCTTAGGGCAGCATAAAGGCCCTATATTTGCATTAAAATGGAATAAGAAAGGAAATTTCATCCTAAGT
GCTGGAGTAGACAAGACTACAATTATTTGGGACGCACATACTGGTGAAGCCAAGCAACAGTTTCCTTTTCATTCAGCACCAGCATTGGAT
GTTGATTGGCAGAGCAACAACACCTTTGCTTCTTGTAGTACAGATATGTGCATTCATGTCTGTAAATTAGGACAAGACAGACCTATTAAA
ACATTCCAAGGACATACGAATGAAGTAAATGCTATCAAATGGGACCCAACTGGCAATCTCTTGGCCTCCTGTTCTGACGACATGACTTTA
AAGATATGGAGTATGAAACAAGACAATTGTGTCCATGATTTGCAAGCACATAATAAAGAAATTTATACTATCAAATGGAGTCCAACAGGA
CCAGGGACTAATAATCCAAATGCCAACCTTATGTTAGCAAGTGCATCCTTTGATTCTACTGTTAGGTTATGGGATGTAGACCGAGGGATA
TGCATCCATACCTTGACAAAACACCAAGAGCCTGTGTACAGTGTAGCTTTCAGTCCTGATGGCAGGTATCTGGCAAGTGGTTCTTTTGAC
AAATGTGTACACATCTGGAACACGCAGACAGGTGCTCTAGTTCACAGCTATAGGGGAACAGGTGGAATATTTGAAGTTTGCTGGAATGCA
GCAGGAGACAAAGTTGGAGCCAGTGCATCAGATGGTTCAGTTTGTGTATTAGACCTTCGGAAATAGCGCTACTAGTTGGAAGCCATGGAC
CGACTATGAATGTGTACATAGCCAAAATGACTGTCCCTGACCCATGTACTGCTATAGTCCCACTTGAACCATGGCCAGTCCACTACAGCC
AAATCTAAAAGAAATATATACATACAGTGTATATAAACAAAATTGCACCCTGAAGATGACAGAGTTTTGTCACAGCTTGTGAATTCTGTT
CACCAAGTGCTGGAATCTAATCTGCTGTGCCCCTAAAATAGCATTTAGAAGTTTTGGATATGAAAAACAGAAGAGAGAAAAATATACATT
ATAAAAGCAGAACATACATGTACCAGTTTTTGGATACTAAATGACAGCCTTGTTTCTCCCCTTTGAATCAGCAGACACCATGGATTATAT
TCTTTTTTTCCCTTCAGTAGTGAGCAGTTTGTATGTACAGAGAAAATGGACTTACAAAAACTTGCAGCAGTAGTTTGTTCTTGCTTTAAA
ATTTCGTTTTTGGTTTAGATTATGGATGCATGAAGTAAGGGAGTGAATCAGTTTCTTGTTTATATTTTTTTCACCTTTTAAACAAAAAAT
TCTTTAAAATATTTTAATGCATTCTTTTGAAGAGGTAGATGTTTGGTACATTTTATGGCTCCCAGAGCATATATTCAGTTGGTGCATGTT
GTGGAAGGGGGAATTGGAAATTAAATGAAAACCTATGACTTTGGTCATGTCAATCTGTAAGACACATCAGTAAAAGGGTATTATGCTCTG
TTGGTTTTGTTTTTTTGTTTTGCTTTTTTTTTTTTTTTTTCTTTTTTGTTTTTTGGTGATGTGGCTTAAATGCAATAGTTTCTTTTTTGG
GACATATTTCTGCCAATTAAAGACTAGAAGGGCACAACTTTTTTTTTAATTACCATAGAGAAGATACATTAAAAAAAATCTTCTGATGTT
TTGTAGCCATAACTAAATTATGGTAAAAATGTGCACTATTGTGAAAAGGAGCAACGTAGTTTTGGGTTTTTTGTTGTTTGTTTGTTTTGC
TTTGTTTTTTAAGAGATTAAAATGTTTCTGGATAAGGATTAGCTTCTCGAAGTGTCCATCATTCTGTGTAGAAGCTTAAATATGTAATGT
AACCAAACTCCAGTATTAAAAATCTCTCATGTTGTTTTCTTTATACAAAGCAAGATAACGGCATATAACACTGCCATTACATGGCAAAAT
GTTTGCTACCTTAGTTTAAAAAACAATCTCAAACAAAAGACTTGCTTCAAGGTGTTTTTAAATAGCAGTGATTCAGAATTTTTTTTAATG
AAAGTATAATTGCACTAACCTTCTTCCTGCTGCTCTGATTCTGCATTTGTGGTACTTGTGACTACGTTTTTTCAAATATAGATAGATTTA
AGCTGCTAATTTTTTTTTTTTTAGTAATCACTACTATATCATGTCTTTTACTCTGTTTATAATATCAAGTATTTTCTTAAAGATATAGAT
ATTAAACCTTGTGCTCATGCAACTTAGAGTAACATATACAGACAAATGATTGCATGAGGCCATGTTTATATGTGTGACTAATAAGGCTTG
TCATGATTAACATAATCCAGGTATGTCATTTCTGAAGAGAATAGTCATCAAATTTATATCTCGAAGATTTTAATTAAGGAATTGCTTATT
GTTGAGCTTAGCAAATTAATAACACTATTTCTGTCACTAATTATTTTGAGGCCTTTTAGTACTAAAATTTTAACCTGTGTTCTAAGTAGA
AACTGATTTAACCCAAGTAATGCAGCTTTGATTGATTTCAGCATTCGTTGCTTTGCTATTTTTACAAAACAGCATTGATTGAAGCAAGTC
TTGGTTTTACTAAGGTAGGGTAGCATTTGCTATTGGTAAAGAGAATAAATACACTTAATTTCACAATACATTGTTATATGTACCCCAGTT
GTTGTTAGTGGGGACTATGATACTGTAATAATATTTTTAAAAATTTACATCAAGAGAGGCAGTCATTCACGATGGTTTTGTGCCAGCTCT
TTTTAGGGTTTTGGATCACATTAGAGATATTTAGAACATATTACCCTGTGACTTACGTAGGAAACCTAATATGCTGAGTATCTGGCACTT

>44167_44167_4_LARS2-TBL1XR1_LARS2_chr3_45461221_ENST00000414984_TBL1XR1_chr3_176769514_ENST00000457928_length(amino acids)=575AA_BP=129
MASVWQRLGFYASLLKRQLNGGPDVIKWERRVIPGCTRSIYSATGKWTKEYTLQTRKDVEKWWHQRIKEQASKISEADVINPMGWDAFGL
PAENAAVERNLHPQSWTQSNIKHMRKQLDRLGLCFSWDRDGTLFDGRPIESLSLIDAVMPDVVQTRQQAYRDKLAQQQAAAAAAAAAAAS
QQGSAKNGENTANGEENGAHTIANNHTDMMEVDGDVEIPPNKAVVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLSENSTSGSTQL
VLRHCIREGGQDVPSNKDVTSLDWNSEGTLLATGSYDGFARIWTKDGNLASTLGQHKGPIFALKWNKKGNFILSAGVDKTTIIWDAHTGE
AKQQFPFHSAPALDVDWQSNNTFASCSTDMCIHVCKLGQDRPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQA
HNKEIYTIKWSPTGPGTNNPNANLMLASASFDSTVRLWDVDRGICIHTLTKHQEPVYSVAFSPDGRYLASGSFDKCVHIWNTQTGALVHS

--------------------------------------------------------------
>44167_44167_5_LARS2-TBL1XR1_LARS2_chr3_45461221_ENST00000415258_TBL1XR1_chr3_176769514_ENST00000430069_length(transcript)=8141nt_BP=657nt
GCTATCGATAAAGTTGCTGTTTTGACAACATGGCGGCGCCCATGGTCCGTGGCCCGGCAGTGCTCGCCTAAAGGTGGAGAACGAGGAGTA
GAGGAGCCGCAGGCCAGAGCCTGTGAGCAGGGCCTTCTCACCTTCTGAAGAATGGCTTCTGTTTGGCAGAGATTGGGTTTTTATGCCTCT
CTTCTGAAAAGACAGCTAAATGGTGGGCCAGATGTCATCAAGTGGGAAAGGAGAGTAATTCCCGGATGTACCAGAAGCATCTACAGTGCC
ACGGGAAAGTGGACAAAAGAGTATACATTGCAGACAAGAAAGGATGTTGAGAAATGGTGGCATCAACGAATAAAAGAACAGGCCTCCAAA
ATTTCAGAAGCTGATAAATCGAAGCCAAAATTTTACGTGCTTTCCATGTTCCCTTATCCTTCTGGTAAGCTGCACATGGGCCATGTGCGT
GTCTACACCATCAGCGACACCATAGCACGGTTCCAGAAGATGAGAGGGATGCAGGTCATCAACCCCATGGGATGGGATGCTTTTGGATTG
CCTGCTGAAAATGCCGCAGTCGAGAGGAATCTACATCCACAAAGTTGGACACAAAGTAATATTAAACACATGAGGAAACAGCTTGATCGT
CTGGGCCTGTGTTTCAGCTGGGATAGGGATGGTACCTTGTTTGATGGTCGACCAATAGAGTCTCTGTCCCTGATAGATGCCGTAATGCCT
GATGTAGTACAAACAAGACAACAAGCTTATAGAGATAAGCTTGCACAGCAACAGGCAGCAGCTGCTGCAGCTGCCGCAGCTGCAGCCAGC
CAACAAGGATCTGCAAAAAATGGAGAAAACACAGCAAATGGGGAGGAGAATGGAGCACATACTATAGCAAATAATCATACTGATATGATG
GAAGTGGATGGGGATGTTGAAATCCCTCCTAATAAAGCTGTTGTGTTGCGGGGCCATGAATCTGAAGTTTTTATCTGTGCCTGGAACCCT
GTTAGTGATCTCCTAGCATCAGGGTCTGGAGACTCAACAGCAAGAATATGGAATCTTAGTGAGAACAGCACCAGTGGCTCTACACAGTTA
GTACTTAGACATTGTATACGAGAAGGAGGGCAAGATGTTCCAAGCAACAAGGATGTCACATCTCTAGATTGGAATAGTGAAGGTACACTT
CTAGCAACTGGTTCCTATGATGGGTTTGCCAGAATATGGACTAAAGATGGTAACCTTGCTAGCACCTTAGGGCAGCATAAAGGCCCTATA
TTTGCATTAAAATGGAATAAGAAAGGAAATTTCATCCTAAGTGCTGGAGTAGACAAGACTACAATTATTTGGGACGCACATACTGGTGAA
GCCAAGCAACAGTTTCCTTTTCATTCAGCACCAGCATTGGATGTTGATTGGCAGAGCAACAACACCTTTGCTTCTTGTAGTACAGATATG
TGCATTCATGTCTGTAAATTAGGACAAGACAGACCTATTAAAACATTCCAAGGACATACGAATGAAGTAAATGCTATCAAATGGGACCCA
ACTGGCAATCTCTTGGCCTCCTGTTCTGACGACATGACTTTAAAGATATGGAGTATGAAACAAGACAATTGTGTCCATGATTTGCAAGCA
CATAATAAAGAAATTTATACTATCAAATGGAGTCCAACAGGACCAGGGACTAATAATCCAAATGCCAACCTTATGTTAGCAAGTGCATCC
TTTGATTCTACTGTTAGGTTATGGGATGTAGACCGAGGGATATGCATCCATACCTTGACAAAACACCAAGAGCCTGTGTACAGTGTAGCT
TTCAGTCCTGATGGCAGGTATCTGGCAAGTGGTTCTTTTGACAAATGTGTACACATCTGGAACACGCAGACAGGTGCTCTAGTTCACAGC
TATAGGGGAACAGGTGGAATATTTGAAGTTTGCTGGAATGCAGCAGGAGACAAAGTTGGAGCCAGTGCATCAGATGGTTCAGTTTGTGTA
TTAGACCTTCGGAAATAGCGCTACTAGTTGGAAGCCATGGACCGACTATGAATGTGTACATAGCCAAAATGACTGTCCCTGACCCATGTA
CTGCTATAGTCCCACTTGAACCATGGCCAGTCCACTACAGCCAAATCTAAAAGAAATATATACATACAGTGTATATAAACAAAATTGCAC
CCTGAAGATGACAGAGTTTTGTCACAGCTTGTGAATTCTGTTCACCAAGTGCTGGAATCTAATCTGCTGTGCCCCTAAAATAGCATTTAG
AAGTTTTGGATATGAAAAACAGAAGAGAGAAAAATATACATTATAAAAGCAGAACATACATGTACCAGTTTTTGGATACTAAATGACAGC
CTTGTTTCTCCCCTTTGAATCAGCAGACACCATGGATTATATTCTTTTTTTCCCTTCAGTAGTGAGCAGTTTGTATGTACAGAGAAAATG
GACTTACAAAAACTTGCAGCAGTAGTTTGTTCTTGCTTTAAAATTTCGTTTTTGGTTTAGATTATGGATGCATGAAGTAAGGGAGTGAAT
CAGTTTCTTGTTTATATTTTTTTCACCTTTTAAACAAAAAATTCTTTAAAATATTTTAATGCATTCTTTTGAAGAGGTAGATGTTTGGTA
CATTTTATGGCTCCCAGAGCATATATTCAGTTGGTGCATGTTGTGGAAGGGGGAATTGGAAATTAAATGAAAACCTATGACTTTGGTCAT
GTCAATCTGTAAGACACATCAGTAAAAGGGTATTATGCTCTGTTGGTTTTGTTTTTTTGTTTTGCTTTTTTTTTTTTTTTTTCTTTTTTG
TTTTTTGGTGATGTGGCTTAAATGCAATAGTTTCTTTTTTGGGACATATTTCTGCCAATTAAAGACTAGAAGGGCACAACTTTTTTTTTA
ATTACCATAGAGAAGATACATTAAAAAAAATCTTCTGATGTTTTGTAGCCATAACTAAATTATGGTAAAAATGTGCACTATTGTGAAAAG
GAGCAACGTAGTTTTGGGTTTTTTGTTGTTTGTTTGTTTTGCTTTGTTTTTTAAGAGATTAAAATGTTTCTGGATAAGGATTAGCTTCTC
GAAGTGTCCATCATTCTGTGTAGAAGCTTAAATATGTAATGTAACCAAACTCCAGTATTAAAAATCTCTCATGTTGTTTTCTTTATACAA
AGCAAGATAACGGCATATAACACTGCCATTACATGGCAAAATGTTTGCTACCTTAGTTTAAAAAACAATCTCAAACAAAAGACTTGCTTC
AAGGTGTTTTTAAATAGCAGTGATTCAGAATTTTTTTTAATGAAAGTATAATTGCACTAACCTTCTTCCTGCTGCTCTGATTCTGCATTT
GTGGTACTTGTGACTACGTTTTTTCAAATATAGATAGATTTAAGCTGCTAATTTTTTTTTTTTTAGTAATCACTACTATATCATGTCTTT
TACTCTGTTTATAATATCAAGTATTTTCTTAAAGATATAGATATTAAACCTTGTGCTCATGCAACTTAGAGTAACATATACAGACAAATG
ATTGCATGAGGCCATGTTTATATGTGTGACTAATAAGGCTTGTCATGATTAACATAATCCAGGTATGTCATTTCTGAAGAGAATAGTCAT
CAAATTTATATCTCGAAGATTTTAATTAAGGAATTGCTTATTGTTGAGCTTAGCAAATTAATAACACTATTTCTGTCACTAATTATTTTG
AGGCCTTTTAGTACTAAAATTTTAACCTGTGTTCTAAGTAGAAACTGATTTAACCCAAGTAATGCAGCTTTGATTGATTTCAGCATTCGT
TGCTTTGCTATTTTTACAAAACAGCATTGATTGAAGCAAGTCTTGGTTTTACTAAGGTAGGGTAGCATTTGCTATTGGTAAAGAGAATAA
ATACACTTAATTTCACAATACATTGTTATATGTACCCCAGTTGTTGTTAGTGGGGACTATGATACTGTAATAATATTTTTAAAAATTTAC
ATCAAGAGAGGCAGTCATTCACGATGGTTTTGTGCCAGCTCTTTTTAGGGTTTTGGATCACATTAGAGATATTTAGAACATATTACCCTG
TGACTTACGTAGGAAACCTAATATGCTGAGTATCTGGCACTTGAATTCCTGCTTTTATTGCTGGAGGTCCACATCTGTGGTTGACCTCTG
TTATTGTTTAAAAAAAATAAATAAAAATTAAAAAAATCTGTGCAATAATTTTAAAATGTGCTCCCAGGAATAGACACAAATGTTTTGAGT
ATCTTTTAAGCTGCATTTTCCTTTAGTGATGCATTTGTCAATTGCACTGAATTTAAATCTGAAAGTCAGAGGTGATTATTGATAGTACTT
TTGTATTTTGATATGGACAGTTTATTCATTTGCATACAGTTATTGACTTTTTCCCAGCTGATTAAAAGATAGTCAAGAAATTCTGCAATA
TAGCTGCCAAAATAGACAGCTACATTTTTATGATATTGTCATCTTTTCTGTTTTTTTTTTCTTTTTTTTCTTTAGCTATTTTACTTAAGC
ATAATAGCCACAATAGGACATATAAAAGATTATAAATACAGAGCTTTATTATCCTGACGTCTTGGGTCTTTTAAGTATATACTTTTCTGA
AAGGTATCCATTTTGTAGGCTTGGGTTCTTCATGAGCATACGATTGTTTATTTTTGCTGCTGTTCTCAACATCATCATTGCCTGCTGATG
TGCCACGATGCTGCTCCAATAGACAGCAATAAGATTGTCTCTAATTTGAGCAGTAACATGATTGCAAGAGACCAAGTTTCACAGCTTGTA
AAGTTCTGTATTTGGGATTCTTGCTTATTTTTCCGCCTGTGTTTTTCTGAGAACTTATTCCTGATGATCAATTGAATCCAGTAGTTTTTC
TATGCTATTTGTTGTTGTATAAGCTACTGTAAGAAACTTATCATAAGGAAAAATAGAAAGGAAAACTTGAATCAATACTCATTGATTAAA
ATGGAATAAAGAAAGAGCAGCTGCCACTTTTAAACAACATAAAGGAATATCTTTTTTTGTCTCCGTGTAGGAAATCCCATAAGTTCTTAT
ATTTGTTCCAGTTCCCATTTCCTGCCATTGACCAGATAACATCATTGACTTTCAAATGACTTTTAGAAGTGATAACTCTTAATTTCCTAA
TAGATACTAGATTGTATTGAATTCTGTTTTAATTATTCTCTAGGTAAGTATGTTTTAGGATTAAATACCTTTTACAGATACTGAAAGTGC
CTCCTTTTGTGGTGTAAAAAACAAATTATGGTGCAAAAAGTAATCACTAGATTGAAATACATGAAGGTTTTTTGCTTTTTGACATACGAA
AATGTCAAGAGAAAGGCCAAAGATTTGTACTTTTTCACTTACAAAGCACTCCTTTTTCCCTTAAACTTCTTTCTGTCAAATTAGATTTAA
TGAGAGAGTACTATTTTTAAGGAGCTATCTGTTTATGTAGAATGATTTTGTTAAGAGTAATGTAAACTATTATTGAGTAGAGGCCTAAAG
AGGACTGTGCATTTTTGCTATTTAAAGGAATCACAAATGATCATACTTAAGTGAGCAAAAATGACAAGTTTTACTAGCTAAGTAGAGAAA
TAAATCTCAAATGCAGCGCTACAATTTTCATTATCTTAAGTACATTGTACATTTCTACAGAACCTGTGATTATTCTCGCATGATAAGGAT
GGTACTTGCATATGGTGAATTACTACTGTTGACAGTTTCCGCAGAAATCCTATTTCAGTGGACCAACATTGTGGCATGGCAGCAAATGCC
AACATTTTGTGGAATAGCAGCAAATCTACAAGAGACCCTGGTTGGTTTTTCGTTTTGTTTTCTTTGTTTTTTCCCCCTTCTCCTGAATCA
GCAGGGATGGAAGGAGGGTAGGGAAGTTATGAATTACTCCTTCCAGTAGTAGCTCTGAAGTGTCACATTTAATATCAGTTTTTTTTAAAC
ATGATTCTAGTTAAATGTAGAAGAGAGAAGAAAGAGGAAGTGTTCACTTTTTTAATACACTGATTTAGAAATTTGATGTCTTATATCAGT
AGTTCTGAGGTATTGATAGCTTGCTTTATTTCTGCCTTTACGTTGACAGTGTTGAAGCAGGGTGAATAACTAGGGCATATATTTTTTTTT
TTTTTGTAAGCTGTTTCATGATGTTTTCTTTGGAATTTCCGGATAAGTTCAGGAAAACATTCTGCATGTTGTATCTAGTCTGATGTACTT
ATCCATCTCATTACAAACAAAAACACACAGACTGCATTTGTAGCTCTGTAATCCTTGAATACGGAAGTAAATTTTCTTCTTTCCTGACTT
TGACATTGTAGCTATACTGTTTCCATTTTTGTTTTTACAAATCCTTTGGGTCTAATTCTGTGAGCCTACCTATAGCACTGGATTAAAATG
TCTGCATCATTTCTTTAGTTATCCAGTTAACTTTAAAACTGTTGTAAAAGTGTAAACCAGCCCATGACAGGTTTTTGTACATGTTAAAGA
ACTTCATTGTTCAGTTTTCATGATTATTGTGTAAGGAAGACTGATGTAGATGTTCTGTGCTGTCCTGGACCATGTTAATTACACTTACGA
CGTATTTTAGTTCCACATCACAATGATTTGTCCCCAGTGACCCTTTTATCCTTTCTAGGCACATTTCTTGTTGTTGTTGTTGTTGCAGTT
CCCCTTTGCATTGTATTGCTTTGACAACTGTAATTTGAATCAGATCTGAAAGAGGTCCAGAATAAAATATATTTTGATATTATGTTGGCT
GTGTACATATATAAAACCTTTGATGTCTATGTAGTTTATATAGACTATTTACTAGTCAGGTAAAGAGAGAGGGATGGTATTTCTTGTTTA
CAGTTTGTTTACATTTTAATTGCTTTTACTTCTCCAGTGTTCTATTGTAGAATAAACCTTTTTTTCCAAGTTAGCCTTCATAACCTATAA
CACATTCATTCTCTCCCATACTGGTGTTACTGATTAATAACTGCCATCAGAACCCAAACCACTGTTTTTCATAAACGTATTGTTTCCCAA
GATATATACTTTAAGCCCATAATAAAATTACAAATTTTACTATTTTTATTACTTCTTGCAGGAGATAAGATTTTTTTAAATGAAGGGGTT
ATTTACTATTTTTATTAAAGTATAATAGAGCATCTAATCAGCTAAGGGATTGTAATTTTTAATTCTTTTGAAAAATAAATATTGTATTTA
AAAGACGTTATTTCACAGAAGCTGAAAAAGAGACCTTAGATAACATTTGTTTGGTTAGCCACACGGTTGAGCACAAAACAATGTGTAGAT
GTGTTGAAGATTAGGGCAGGAGGCTCAACTTCTCGGTGACCTTTTTTTGCTTCACAACAAGCCAATTATAGTTGAATCATTTTCTCTCTT
AGCTAGTTGTTACTACAAACTTTATAAGAAAAACAACTAGACACCTTCTAGTTTTAATTAATACCAACTCCTTTAGAGTTAGAGACTTTT
TAAAAAGAATCATTGAGCATATTTTCTTTTTTTTTTTTTTAAGAATTTACACTCTCTAGGTCTTCTATTTTTCCTGTTTATTTCCTTAAA
CAGAAATAAATTCAAGCATAGTTTTATGTTTTATTAGAAATAAGCCACTGCAGTTGCTAGAACTGACATGCTTTCATTTTCAAGGGGTTA
ACTTTTATTGCATGGCATAGATTATTAGTAATATCCTGCATTGTATACTTTTCCAAAAAGGGTTGGACTCCTAAGGATTAGAATCCTTAT
AAGCTTGAGGGAAAGCTGAAACTAATTTGAACAGTAATAGAAGGGATTATTTTTAATTTCATAGTTAACACTTTACAATGGATTAGATTT
ATTACCTAGTATAATCCGTAGCAGATCAGATCAAAGTTTACTGTTTTACCAATATATTCATTTGAAAAAATACAGTGGAGGAAAAGACAC
TTTAGATGGTAGTTTTATGGTGCTTTTCTCTGCTGTACCAAAGTGCTTTGTCATCAATGAAATGTTAACCCTATGCTACTTTTTCTGCAT
GCTTCTTAAATGTCATCTTAATGCTTAATTGTCCTAACTTGTAATATTTTTGTATTAAATTTTTTTAGGAGTTCCTTGTAATTTCTTTAC

>44167_44167_5_LARS2-TBL1XR1_LARS2_chr3_45461221_ENST00000415258_TBL1XR1_chr3_176769514_ENST00000430069_length(amino acids)=618AA_BP=172
MASVWQRLGFYASLLKRQLNGGPDVIKWERRVIPGCTRSIYSATGKWTKEYTLQTRKDVEKWWHQRIKEQASKISEADKSKPKFYVLSMF
PYPSGKLHMGHVRVYTISDTIARFQKMRGMQVINPMGWDAFGLPAENAAVERNLHPQSWTQSNIKHMRKQLDRLGLCFSWDRDGTLFDGR
PIESLSLIDAVMPDVVQTRQQAYRDKLAQQQAAAAAAAAAAASQQGSAKNGENTANGEENGAHTIANNHTDMMEVDGDVEIPPNKAVVLR
GHESEVFICAWNPVSDLLASGSGDSTARIWNLSENSTSGSTQLVLRHCIREGGQDVPSNKDVTSLDWNSEGTLLATGSYDGFARIWTKDG
NLASTLGQHKGPIFALKWNKKGNFILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQSNNTFASCSTDMCIHVCKLGQDRPIKTFQ
GHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKEIYTIKWSPTGPGTNNPNANLMLASASFDSTVRLWDVDRGICIH

--------------------------------------------------------------
>44167_44167_6_LARS2-TBL1XR1_LARS2_chr3_45461221_ENST00000415258_TBL1XR1_chr3_176769514_ENST00000457928_length(transcript)=4176nt_BP=657nt
GCTATCGATAAAGTTGCTGTTTTGACAACATGGCGGCGCCCATGGTCCGTGGCCCGGCAGTGCTCGCCTAAAGGTGGAGAACGAGGAGTA
GAGGAGCCGCAGGCCAGAGCCTGTGAGCAGGGCCTTCTCACCTTCTGAAGAATGGCTTCTGTTTGGCAGAGATTGGGTTTTTATGCCTCT
CTTCTGAAAAGACAGCTAAATGGTGGGCCAGATGTCATCAAGTGGGAAAGGAGAGTAATTCCCGGATGTACCAGAAGCATCTACAGTGCC
ACGGGAAAGTGGACAAAAGAGTATACATTGCAGACAAGAAAGGATGTTGAGAAATGGTGGCATCAACGAATAAAAGAACAGGCCTCCAAA
ATTTCAGAAGCTGATAAATCGAAGCCAAAATTTTACGTGCTTTCCATGTTCCCTTATCCTTCTGGTAAGCTGCACATGGGCCATGTGCGT
GTCTACACCATCAGCGACACCATAGCACGGTTCCAGAAGATGAGAGGGATGCAGGTCATCAACCCCATGGGATGGGATGCTTTTGGATTG
CCTGCTGAAAATGCCGCAGTCGAGAGGAATCTACATCCACAAAGTTGGACACAAAGTAATATTAAACACATGAGGAAACAGCTTGATCGT
CTGGGCCTGTGTTTCAGCTGGGATAGGGATGGTACCTTGTTTGATGGTCGACCAATAGAGTCTCTGTCCCTGATAGATGCCGTAATGCCT
GATGTAGTACAAACAAGACAACAAGCTTATAGAGATAAGCTTGCACAGCAACAGGCAGCAGCTGCTGCAGCTGCCGCAGCTGCAGCCAGC
CAACAAGGATCTGCAAAAAATGGAGAAAACACAGCAAATGGGGAGGAGAATGGAGCACATACTATAGCAAATAATCATACTGATATGATG
GAAGTGGATGGGGATGTTGAAATCCCTCCTAATAAAGCTGTTGTGTTGCGGGGCCATGAATCTGAAGTTTTTATCTGTGCCTGGAACCCT
GTTAGTGATCTCCTAGCATCAGGGTCTGGAGACTCAACAGCAAGAATATGGAATCTTAGTGAGAACAGCACCAGTGGCTCTACACAGTTA
GTACTTAGACATTGTATACGAGAAGGAGGGCAAGATGTTCCAAGCAACAAGGATGTCACATCTCTAGATTGGAATAGTGAAGGTACACTT
CTAGCAACTGGTTCCTATGATGGGTTTGCCAGAATATGGACTAAAGATGGTAACCTTGCTAGCACCTTAGGGCAGCATAAAGGCCCTATA
TTTGCATTAAAATGGAATAAGAAAGGAAATTTCATCCTAAGTGCTGGAGTAGACAAGACTACAATTATTTGGGACGCACATACTGGTGAA
GCCAAGCAACAGTTTCCTTTTCATTCAGCACCAGCATTGGATGTTGATTGGCAGAGCAACAACACCTTTGCTTCTTGTAGTACAGATATG
TGCATTCATGTCTGTAAATTAGGACAAGACAGACCTATTAAAACATTCCAAGGACATACGAATGAAGTAAATGCTATCAAATGGGACCCA
ACTGGCAATCTCTTGGCCTCCTGTTCTGACGACATGACTTTAAAGATATGGAGTATGAAACAAGACAATTGTGTCCATGATTTGCAAGCA
CATAATAAAGAAATTTATACTATCAAATGGAGTCCAACAGGACCAGGGACTAATAATCCAAATGCCAACCTTATGTTAGCAAGTGCATCC
TTTGATTCTACTGTTAGGTTATGGGATGTAGACCGAGGGATATGCATCCATACCTTGACAAAACACCAAGAGCCTGTGTACAGTGTAGCT
TTCAGTCCTGATGGCAGGTATCTGGCAAGTGGTTCTTTTGACAAATGTGTACACATCTGGAACACGCAGACAGGTGCTCTAGTTCACAGC
TATAGGGGAACAGGTGGAATATTTGAAGTTTGCTGGAATGCAGCAGGAGACAAAGTTGGAGCCAGTGCATCAGATGGTTCAGTTTGTGTA
TTAGACCTTCGGAAATAGCGCTACTAGTTGGAAGCCATGGACCGACTATGAATGTGTACATAGCCAAAATGACTGTCCCTGACCCATGTA
CTGCTATAGTCCCACTTGAACCATGGCCAGTCCACTACAGCCAAATCTAAAAGAAATATATACATACAGTGTATATAAACAAAATTGCAC
CCTGAAGATGACAGAGTTTTGTCACAGCTTGTGAATTCTGTTCACCAAGTGCTGGAATCTAATCTGCTGTGCCCCTAAAATAGCATTTAG
AAGTTTTGGATATGAAAAACAGAAGAGAGAAAAATATACATTATAAAAGCAGAACATACATGTACCAGTTTTTGGATACTAAATGACAGC
CTTGTTTCTCCCCTTTGAATCAGCAGACACCATGGATTATATTCTTTTTTTCCCTTCAGTAGTGAGCAGTTTGTATGTACAGAGAAAATG
GACTTACAAAAACTTGCAGCAGTAGTTTGTTCTTGCTTTAAAATTTCGTTTTTGGTTTAGATTATGGATGCATGAAGTAAGGGAGTGAAT
CAGTTTCTTGTTTATATTTTTTTCACCTTTTAAACAAAAAATTCTTTAAAATATTTTAATGCATTCTTTTGAAGAGGTAGATGTTTGGTA
CATTTTATGGCTCCCAGAGCATATATTCAGTTGGTGCATGTTGTGGAAGGGGGAATTGGAAATTAAATGAAAACCTATGACTTTGGTCAT
GTCAATCTGTAAGACACATCAGTAAAAGGGTATTATGCTCTGTTGGTTTTGTTTTTTTGTTTTGCTTTTTTTTTTTTTTTTTCTTTTTTG
TTTTTTGGTGATGTGGCTTAAATGCAATAGTTTCTTTTTTGGGACATATTTCTGCCAATTAAAGACTAGAAGGGCACAACTTTTTTTTTA
ATTACCATAGAGAAGATACATTAAAAAAAATCTTCTGATGTTTTGTAGCCATAACTAAATTATGGTAAAAATGTGCACTATTGTGAAAAG
GAGCAACGTAGTTTTGGGTTTTTTGTTGTTTGTTTGTTTTGCTTTGTTTTTTAAGAGATTAAAATGTTTCTGGATAAGGATTAGCTTCTC
GAAGTGTCCATCATTCTGTGTAGAAGCTTAAATATGTAATGTAACCAAACTCCAGTATTAAAAATCTCTCATGTTGTTTTCTTTATACAA
AGCAAGATAACGGCATATAACACTGCCATTACATGGCAAAATGTTTGCTACCTTAGTTTAAAAAACAATCTCAAACAAAAGACTTGCTTC
AAGGTGTTTTTAAATAGCAGTGATTCAGAATTTTTTTTAATGAAAGTATAATTGCACTAACCTTCTTCCTGCTGCTCTGATTCTGCATTT
GTGGTACTTGTGACTACGTTTTTTCAAATATAGATAGATTTAAGCTGCTAATTTTTTTTTTTTTAGTAATCACTACTATATCATGTCTTT
TACTCTGTTTATAATATCAAGTATTTTCTTAAAGATATAGATATTAAACCTTGTGCTCATGCAACTTAGAGTAACATATACAGACAAATG
ATTGCATGAGGCCATGTTTATATGTGTGACTAATAAGGCTTGTCATGATTAACATAATCCAGGTATGTCATTTCTGAAGAGAATAGTCAT
CAAATTTATATCTCGAAGATTTTAATTAAGGAATTGCTTATTGTTGAGCTTAGCAAATTAATAACACTATTTCTGTCACTAATTATTTTG
AGGCCTTTTAGTACTAAAATTTTAACCTGTGTTCTAAGTAGAAACTGATTTAACCCAAGTAATGCAGCTTTGATTGATTTCAGCATTCGT
TGCTTTGCTATTTTTACAAAACAGCATTGATTGAAGCAAGTCTTGGTTTTACTAAGGTAGGGTAGCATTTGCTATTGGTAAAGAGAATAA
ATACACTTAATTTCACAATACATTGTTATATGTACCCCAGTTGTTGTTAGTGGGGACTATGATACTGTAATAATATTTTTAAAAATTTAC
ATCAAGAGAGGCAGTCATTCACGATGGTTTTGTGCCAGCTCTTTTTAGGGTTTTGGATCACATTAGAGATATTTAGAACATATTACCCTG
TGACTTACGTAGGAAACCTAATATGCTGAGTATCTGGCACTTGAATTCCTGCTTTTATTGCTGGAGGTCCACATCTGTGGTTGACCTCTG

>44167_44167_6_LARS2-TBL1XR1_LARS2_chr3_45461221_ENST00000415258_TBL1XR1_chr3_176769514_ENST00000457928_length(amino acids)=618AA_BP=172
MASVWQRLGFYASLLKRQLNGGPDVIKWERRVIPGCTRSIYSATGKWTKEYTLQTRKDVEKWWHQRIKEQASKISEADKSKPKFYVLSMF
PYPSGKLHMGHVRVYTISDTIARFQKMRGMQVINPMGWDAFGLPAENAAVERNLHPQSWTQSNIKHMRKQLDRLGLCFSWDRDGTLFDGR
PIESLSLIDAVMPDVVQTRQQAYRDKLAQQQAAAAAAAAAAASQQGSAKNGENTANGEENGAHTIANNHTDMMEVDGDVEIPPNKAVVLR
GHESEVFICAWNPVSDLLASGSGDSTARIWNLSENSTSGSTQLVLRHCIREGGQDVPSNKDVTSLDWNSEGTLLATGSYDGFARIWTKDG
NLASTLGQHKGPIFALKWNKKGNFILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQSNNTFASCSTDMCIHVCKLGQDRPIKTFQ
GHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKEIYTIKWSPTGPGTNNPNANLMLASASFDSTVRLWDVDRGICIH

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Fusion Gene PPI Analysis for LARS2-TBL1XR1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for LARS2-TBL1XR1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for LARS2-TBL1XR1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource