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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:LATS1-KATNA1 (FusionGDB2 ID:44205) |
Fusion Gene Summary for LATS1-KATNA1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: LATS1-KATNA1 | Fusion gene ID: 44205 | Hgene | Tgene | Gene symbol | LATS1 | KATNA1 | Gene ID | 9113 | 11104 |
| Gene name | large tumor suppressor kinase 1 | katanin catalytic subunit A1 | |
| Synonyms | WARTS|wts | - | |
| Cytomap | 6q25.1 | 6q25.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | serine/threonine-protein kinase LATS1LATS (large tumor suppressor, Drosophila) homolog 1LATS, large tumor suppressor, homolog 1WARTS protein kinaseh-wartslarge tumor suppressor homolog 1 | katanin p60 ATPase-containing subunit A1katanin p60 (ATPase containing) subunit A 1katanin p60 subunit A1p60 katanin | |
| Modification date | 20200313 | 20200315 | |
| UniProtAcc | O95835 | O75449 | |
| Ensembl transtripts involved in fusion gene | ENST00000392273, ENST00000543571, ENST00000253339, ENST00000542747, | ENST00000335647, ENST00000494504, ENST00000335643, ENST00000367411, | |
| Fusion gene scores | * DoF score | 5 X 4 X 5=100 | 5 X 6 X 4=120 |
| # samples | 7 | 5 | |
| ** MAII score | log2(7/100*10)=-0.514573172829758 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/120*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: LATS1 [Title/Abstract] AND KATNA1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | KATNA1(149944239)-LATS1(150005728), # samples:1 LATS1(150038985)-KATNA1(149925918), # samples:1 LATS1(150038985)-KATNA1(149924509), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | KATNA1-LATS1 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. KATNA1-LATS1 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF. KATNA1-LATS1 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. KATNA1-LATS1 seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF. KATNA1-LATS1 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | LATS1 | GO:0000086 | G2/M transition of mitotic cell cycle | 15122335 |
| Hgene | LATS1 | GO:0000819 | sister chromatid segregation | 15122335 |
| Hgene | LATS1 | GO:0006468 | protein phosphorylation | 10518011 |
| Hgene | LATS1 | GO:0030833 | regulation of actin filament polymerization | 15220930 |
| Hgene | LATS1 | GO:0033138 | positive regulation of peptidyl-serine phosphorylation | 20412773 |
| Hgene | LATS1 | GO:0035329 | hippo signaling | 20412773 |
| Hgene | LATS1 | GO:0045736 | negative regulation of cyclin-dependent protein serine/threonine kinase activity | 9988268 |
| Fusion gene breakpoints across LATS1 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene breakpoints across KATNA1 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | STAD | TCGA-D7-6822-01A | LATS1 | chr6 | 150038985 | - | KATNA1 | chr6 | 149924509 | - |
| ChimerDB4 | STAD | TCGA-D7-6822-01A | LATS1 | chr6 | 150038985 | - | KATNA1 | chr6 | 149925918 | - |
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Fusion Gene ORF analysis for LATS1-KATNA1 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5UTR-3CDS | ENST00000392273 | ENST00000335647 | LATS1 | chr6 | 150038985 | - | KATNA1 | chr6 | 149924509 | - |
| 5UTR-3CDS | ENST00000392273 | ENST00000335647 | LATS1 | chr6 | 150038985 | - | KATNA1 | chr6 | 149925918 | - |
| 5UTR-3CDS | ENST00000543571 | ENST00000335647 | LATS1 | chr6 | 150038985 | - | KATNA1 | chr6 | 149924509 | - |
| 5UTR-3CDS | ENST00000543571 | ENST00000335647 | LATS1 | chr6 | 150038985 | - | KATNA1 | chr6 | 149925918 | - |
| 5UTR-5UTR | ENST00000392273 | ENST00000494504 | LATS1 | chr6 | 150038985 | - | KATNA1 | chr6 | 149924509 | - |
| 5UTR-5UTR | ENST00000392273 | ENST00000494504 | LATS1 | chr6 | 150038985 | - | KATNA1 | chr6 | 149925918 | - |
| 5UTR-5UTR | ENST00000543571 | ENST00000494504 | LATS1 | chr6 | 150038985 | - | KATNA1 | chr6 | 149924509 | - |
| 5UTR-5UTR | ENST00000543571 | ENST00000494504 | LATS1 | chr6 | 150038985 | - | KATNA1 | chr6 | 149925918 | - |
| 5UTR-intron | ENST00000392273 | ENST00000335643 | LATS1 | chr6 | 150038985 | - | KATNA1 | chr6 | 149924509 | - |
| 5UTR-intron | ENST00000392273 | ENST00000335643 | LATS1 | chr6 | 150038985 | - | KATNA1 | chr6 | 149925918 | - |
| 5UTR-intron | ENST00000392273 | ENST00000367411 | LATS1 | chr6 | 150038985 | - | KATNA1 | chr6 | 149924509 | - |
| 5UTR-intron | ENST00000392273 | ENST00000367411 | LATS1 | chr6 | 150038985 | - | KATNA1 | chr6 | 149925918 | - |
| 5UTR-intron | ENST00000543571 | ENST00000335643 | LATS1 | chr6 | 150038985 | - | KATNA1 | chr6 | 149924509 | - |
| 5UTR-intron | ENST00000543571 | ENST00000335643 | LATS1 | chr6 | 150038985 | - | KATNA1 | chr6 | 149925918 | - |
| 5UTR-intron | ENST00000543571 | ENST00000367411 | LATS1 | chr6 | 150038985 | - | KATNA1 | chr6 | 149924509 | - |
| 5UTR-intron | ENST00000543571 | ENST00000367411 | LATS1 | chr6 | 150038985 | - | KATNA1 | chr6 | 149925918 | - |
| intron-3CDS | ENST00000253339 | ENST00000335647 | LATS1 | chr6 | 150038985 | - | KATNA1 | chr6 | 149924509 | - |
| intron-3CDS | ENST00000253339 | ENST00000335647 | LATS1 | chr6 | 150038985 | - | KATNA1 | chr6 | 149925918 | - |
| intron-3CDS | ENST00000542747 | ENST00000335647 | LATS1 | chr6 | 150038985 | - | KATNA1 | chr6 | 149924509 | - |
| intron-3CDS | ENST00000542747 | ENST00000335647 | LATS1 | chr6 | 150038985 | - | KATNA1 | chr6 | 149925918 | - |
| intron-5UTR | ENST00000253339 | ENST00000494504 | LATS1 | chr6 | 150038985 | - | KATNA1 | chr6 | 149924509 | - |
| intron-5UTR | ENST00000253339 | ENST00000494504 | LATS1 | chr6 | 150038985 | - | KATNA1 | chr6 | 149925918 | - |
| intron-5UTR | ENST00000542747 | ENST00000494504 | LATS1 | chr6 | 150038985 | - | KATNA1 | chr6 | 149924509 | - |
| intron-5UTR | ENST00000542747 | ENST00000494504 | LATS1 | chr6 | 150038985 | - | KATNA1 | chr6 | 149925918 | - |
| intron-intron | ENST00000253339 | ENST00000335643 | LATS1 | chr6 | 150038985 | - | KATNA1 | chr6 | 149924509 | - |
| intron-intron | ENST00000253339 | ENST00000335643 | LATS1 | chr6 | 150038985 | - | KATNA1 | chr6 | 149925918 | - |
| intron-intron | ENST00000253339 | ENST00000367411 | LATS1 | chr6 | 150038985 | - | KATNA1 | chr6 | 149924509 | - |
| intron-intron | ENST00000253339 | ENST00000367411 | LATS1 | chr6 | 150038985 | - | KATNA1 | chr6 | 149925918 | - |
| intron-intron | ENST00000542747 | ENST00000335643 | LATS1 | chr6 | 150038985 | - | KATNA1 | chr6 | 149924509 | - |
| intron-intron | ENST00000542747 | ENST00000335643 | LATS1 | chr6 | 150038985 | - | KATNA1 | chr6 | 149925918 | - |
| intron-intron | ENST00000542747 | ENST00000367411 | LATS1 | chr6 | 150038985 | - | KATNA1 | chr6 | 149924509 | - |
| intron-intron | ENST00000542747 | ENST00000367411 | LATS1 | chr6 | 150038985 | - | KATNA1 | chr6 | 149925918 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for LATS1-KATNA1 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for LATS1-KATNA1 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:149944239/:150005728) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| LATS1 | KATNA1 |
| FUNCTION: Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in maintenance of ploidy through its actions in both mitotic progression and the G1 tetraploidy checkpoint. Negatively regulates G2/M transition by down-regulating CDK1 kinase activity. Involved in the control of p53 expression. Affects cytokinesis by regulating actin polymerization through negative modulation of LIMK1. May also play a role in endocrine function. Plays a role in mammary gland epithelial cell differentiation, both through the Hippo signaling pathway and the intracellular estrogen receptor signaling pathway by promoting the degradation of ESR1 (PubMed:28068668). {ECO:0000269|PubMed:10518011, ECO:0000269|PubMed:10831611, ECO:0000269|PubMed:15122335, ECO:0000269|PubMed:15220930, ECO:0000269|PubMed:18158288, ECO:0000269|PubMed:19927127, ECO:0000269|PubMed:28068668}. | FUNCTION: Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth. {ECO:0000255|HAMAP-Rule:MF_03023, ECO:0000269|PubMed:10751153, ECO:0000269|PubMed:11870226, ECO:0000269|PubMed:19287380}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for LATS1-KATNA1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
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Fusion Gene PPI Analysis for LATS1-KATNA1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for LATS1-KATNA1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for LATS1-KATNA1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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