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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:LATS2-MYLK (FusionGDB2 ID:44210)

Fusion Gene Summary for LATS2-MYLK

check button Fusion gene summary
Fusion gene informationFusion gene name: LATS2-MYLK
Fusion gene ID: 44210
HgeneTgene
Gene symbol

LATS2

MYLK

Gene ID

26524

4638

Gene namelarge tumor suppressor kinase 2myosin light chain kinase
SynonymsKPMAAT7|KRP|MLCK|MLCK1|MLCK108|MLCK210|MMIHS|MSTP083|MYLK1|smMLCK
Cytomap

13q12.11

3q21.1

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein kinase LATS2LATS (large tumor suppressor, Drosophila) homolog 2LATS, large tumor suppressor, homolog 2kinase phosphorylated during mitosis proteinlarge tumor suppressor homolog 2serine/threonine kinase KPMserine/threonine-prmyosin light chain kinase, smooth musclekinase-related proteinmyosin, light polypeptide kinasesmooth muscle myosin light chain kinasetelokin
Modification date2020031320200320
UniProtAcc

Q9NRM7

Q86YV6

Ensembl transtripts involved in fusion geneENST00000382592, ENST00000472754, 
ENST00000542899, 		ENST00000359169, 
ENST00000360304, ENST00000360772, 
ENST00000510775, ENST00000346322, 
ENST00000354792, ENST00000418370, 
ENST00000475616, ENST00000578202, 
ENST00000583087, 
Fusion gene scores* DoF score4 X 6 X 3=7214 X 15 X 4=840
# samples 515
** MAII scorelog2(5/72*10)=-0.526068811667588
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/840*10)=-2.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: LATS2 [Title/Abstract] AND MYLK [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointLATS2(21635485)-MYLK(123386034), # samples:5
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneLATS2

GO:0000082

G1/S transition of mitotic cell cycle

12853976

HgeneLATS2

GO:0006468

protein phosphorylation

10871863

HgeneLATS2

GO:0009755

hormone-mediated signaling pathway

15131260

HgeneLATS2

GO:0035329

hippo signaling

20412773

HgeneLATS2

GO:0035556

intracellular signal transduction

10871863

HgeneLATS2

GO:0045736

negative regulation of cyclin-dependent protein serine/threonine kinase activity

12853976

TgeneMYLK

GO:0030335

positive regulation of cell migration

19826488

TgeneMYLK

GO:0051928

positive regulation of calcium ion transport

16284075

TgeneMYLK

GO:0071476

cellular hypotonic response

11976941

TgeneMYLK

GO:0090303

positive regulation of wound healing

15825080


check buttonFusion gene breakpoints across LATS2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across MYLK (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-K1-A42X-01ALATS2chr13

21634332

-MYLKchr3

123386033

-
ChimerDB4SARCTCGA-K1-A42X-01ALATS2chr13

21635485

-MYLKchr3

123386034

-
ChimerDB4SARCTCGA-K1-A42X-02ALATS2chr13

21634332

-MYLKchr3

123386033

-
ChimerDB4SARCTCGA-K1-A42X-02ALATS2chr13

21635485

-MYLKchr3

123386034

-
ChimerDB4SARCTCGA-K1-A42XLATS2chr13

21635484

-MYLKchr3

123386034

-


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Fusion Gene ORF analysis for LATS2-MYLK

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000382592ENST00000359169LATS2chr13

21635485

-MYLKchr3

123386034

-
5UTR-3CDSENST00000382592ENST00000359169LATS2chr13

21635484

-MYLKchr3

123386034

-
5UTR-3CDSENST00000382592ENST00000360304LATS2chr13

21635485

-MYLKchr3

123386034

-
5UTR-3CDSENST00000382592ENST00000360304LATS2chr13

21635484

-MYLKchr3

123386034

-
5UTR-3CDSENST00000382592ENST00000360772LATS2chr13

21635485

-MYLKchr3

123386034

-
5UTR-3CDSENST00000382592ENST00000360772LATS2chr13

21635484

-MYLKchr3

123386034

-
5UTR-5UTRENST00000382592ENST00000510775LATS2chr13

21635485

-MYLKchr3

123386034

-
5UTR-5UTRENST00000382592ENST00000510775LATS2chr13

21635484

-MYLKchr3

123386034

-
5UTR-intronENST00000382592ENST00000346322LATS2chr13

21635485

-MYLKchr3

123386034

-
5UTR-intronENST00000382592ENST00000346322LATS2chr13

21635484

-MYLKchr3

123386034

-
5UTR-intronENST00000382592ENST00000354792LATS2chr13

21635485

-MYLKchr3

123386034

-
5UTR-intronENST00000382592ENST00000354792LATS2chr13

21635484

-MYLKchr3

123386034

-
5UTR-intronENST00000382592ENST00000418370LATS2chr13

21635485

-MYLKchr3

123386034

-
5UTR-intronENST00000382592ENST00000418370LATS2chr13

21635484

-MYLKchr3

123386034

-
5UTR-intronENST00000382592ENST00000475616LATS2chr13

21635485

-MYLKchr3

123386034

-
5UTR-intronENST00000382592ENST00000475616LATS2chr13

21635484

-MYLKchr3

123386034

-
5UTR-intronENST00000382592ENST00000578202LATS2chr13

21635485

-MYLKchr3

123386034

-
5UTR-intronENST00000382592ENST00000578202LATS2chr13

21635484

-MYLKchr3

123386034

-
5UTR-intronENST00000382592ENST00000583087LATS2chr13

21635485

-MYLKchr3

123386034

-
5UTR-intronENST00000382592ENST00000583087LATS2chr13

21635484

-MYLKchr3

123386034

-
intron-3CDSENST00000382592ENST00000359169LATS2chr13

21634332

-MYLKchr3

123386033

-
intron-3CDSENST00000382592ENST00000360304LATS2chr13

21634332

-MYLKchr3

123386033

-
intron-3CDSENST00000382592ENST00000360772LATS2chr13

21634332

-MYLKchr3

123386033

-
intron-3CDSENST00000472754ENST00000359169LATS2chr13

21634332

-MYLKchr3

123386033

-
intron-3CDSENST00000472754ENST00000359169LATS2chr13

21635485

-MYLKchr3

123386034

-
intron-3CDSENST00000472754ENST00000359169LATS2chr13

21635484

-MYLKchr3

123386034

-
intron-3CDSENST00000472754ENST00000360304LATS2chr13

21634332

-MYLKchr3

123386033

-
intron-3CDSENST00000472754ENST00000360304LATS2chr13

21635485

-MYLKchr3

123386034

-
intron-3CDSENST00000472754ENST00000360304LATS2chr13

21635484

-MYLKchr3

123386034

-
intron-3CDSENST00000472754ENST00000360772LATS2chr13

21634332

-MYLKchr3

123386033

-
intron-3CDSENST00000472754ENST00000360772LATS2chr13

21635485

-MYLKchr3

123386034

-
intron-3CDSENST00000472754ENST00000360772LATS2chr13

21635484

-MYLKchr3

123386034

-
intron-3CDSENST00000542899ENST00000359169LATS2chr13

21634332

-MYLKchr3

123386033

-
intron-3CDSENST00000542899ENST00000359169LATS2chr13

21635485

-MYLKchr3

123386034

-
intron-3CDSENST00000542899ENST00000359169LATS2chr13

21635484

-MYLKchr3

123386034

-
intron-3CDSENST00000542899ENST00000360304LATS2chr13

21634332

-MYLKchr3

123386033

-
intron-3CDSENST00000542899ENST00000360304LATS2chr13

21635485

-MYLKchr3

123386034

-
intron-3CDSENST00000542899ENST00000360304LATS2chr13

21635484

-MYLKchr3

123386034

-
intron-3CDSENST00000542899ENST00000360772LATS2chr13

21634332

-MYLKchr3

123386033

-
intron-3CDSENST00000542899ENST00000360772LATS2chr13

21635485

-MYLKchr3

123386034

-
intron-3CDSENST00000542899ENST00000360772LATS2chr13

21635484

-MYLKchr3

123386034

-
intron-5UTRENST00000382592ENST00000510775LATS2chr13

21634332

-MYLKchr3

123386033

-
intron-5UTRENST00000472754ENST00000510775LATS2chr13

21634332

-MYLKchr3

123386033

-
intron-5UTRENST00000472754ENST00000510775LATS2chr13

21635485

-MYLKchr3

123386034

-
intron-5UTRENST00000472754ENST00000510775LATS2chr13

21635484

-MYLKchr3

123386034

-
intron-5UTRENST00000542899ENST00000510775LATS2chr13

21634332

-MYLKchr3

123386033

-
intron-5UTRENST00000542899ENST00000510775LATS2chr13

21635485

-MYLKchr3

123386034

-
intron-5UTRENST00000542899ENST00000510775LATS2chr13

21635484

-MYLKchr3

123386034

-
intron-intronENST00000382592ENST00000346322LATS2chr13

21634332

-MYLKchr3

123386033

-
intron-intronENST00000382592ENST00000354792LATS2chr13

21634332

-MYLKchr3

123386033

-
intron-intronENST00000382592ENST00000418370LATS2chr13

21634332

-MYLKchr3

123386033

-
intron-intronENST00000382592ENST00000475616LATS2chr13

21634332

-MYLKchr3

123386033

-
intron-intronENST00000382592ENST00000578202LATS2chr13

21634332

-MYLKchr3

123386033

-
intron-intronENST00000382592ENST00000583087LATS2chr13

21634332

-MYLKchr3

123386033

-
intron-intronENST00000472754ENST00000346322LATS2chr13

21634332

-MYLKchr3

123386033

-
intron-intronENST00000472754ENST00000346322LATS2chr13

21635485

-MYLKchr3

123386034

-
intron-intronENST00000472754ENST00000346322LATS2chr13

21635484

-MYLKchr3

123386034

-
intron-intronENST00000472754ENST00000354792LATS2chr13

21634332

-MYLKchr3

123386033

-
intron-intronENST00000472754ENST00000354792LATS2chr13

21635485

-MYLKchr3

123386034

-
intron-intronENST00000472754ENST00000354792LATS2chr13

21635484

-MYLKchr3

123386034

-
intron-intronENST00000472754ENST00000418370LATS2chr13

21634332

-MYLKchr3

123386033

-
intron-intronENST00000472754ENST00000418370LATS2chr13

21635485

-MYLKchr3

123386034

-
intron-intronENST00000472754ENST00000418370LATS2chr13

21635484

-MYLKchr3

123386034

-
intron-intronENST00000472754ENST00000475616LATS2chr13

21634332

-MYLKchr3

123386033

-
intron-intronENST00000472754ENST00000475616LATS2chr13

21635485

-MYLKchr3

123386034

-
intron-intronENST00000472754ENST00000475616LATS2chr13

21635484

-MYLKchr3

123386034

-
intron-intronENST00000472754ENST00000578202LATS2chr13

21634332

-MYLKchr3

123386033

-
intron-intronENST00000472754ENST00000578202LATS2chr13

21635485

-MYLKchr3

123386034

-
intron-intronENST00000472754ENST00000578202LATS2chr13

21635484

-MYLKchr3

123386034

-
intron-intronENST00000472754ENST00000583087LATS2chr13

21634332

-MYLKchr3

123386033

-
intron-intronENST00000472754ENST00000583087LATS2chr13

21635485

-MYLKchr3

123386034

-
intron-intronENST00000472754ENST00000583087LATS2chr13

21635484

-MYLKchr3

123386034

-
intron-intronENST00000542899ENST00000346322LATS2chr13

21634332

-MYLKchr3

123386033

-
intron-intronENST00000542899ENST00000346322LATS2chr13

21635485

-MYLKchr3

123386034

-
intron-intronENST00000542899ENST00000346322LATS2chr13

21635484

-MYLKchr3

123386034

-
intron-intronENST00000542899ENST00000354792LATS2chr13

21634332

-MYLKchr3

123386033

-
intron-intronENST00000542899ENST00000354792LATS2chr13

21635485

-MYLKchr3

123386034

-
intron-intronENST00000542899ENST00000354792LATS2chr13

21635484

-MYLKchr3

123386034

-
intron-intronENST00000542899ENST00000418370LATS2chr13

21634332

-MYLKchr3

123386033

-
intron-intronENST00000542899ENST00000418370LATS2chr13

21635485

-MYLKchr3

123386034

-
intron-intronENST00000542899ENST00000418370LATS2chr13

21635484

-MYLKchr3

123386034

-
intron-intronENST00000542899ENST00000475616LATS2chr13

21634332

-MYLKchr3

123386033

-
intron-intronENST00000542899ENST00000475616LATS2chr13

21635485

-MYLKchr3

123386034

-
intron-intronENST00000542899ENST00000475616LATS2chr13

21635484

-MYLKchr3

123386034

-
intron-intronENST00000542899ENST00000578202LATS2chr13

21634332

-MYLKchr3

123386033

-
intron-intronENST00000542899ENST00000578202LATS2chr13

21635485

-MYLKchr3

123386034

-
intron-intronENST00000542899ENST00000578202LATS2chr13

21635484

-MYLKchr3

123386034

-
intron-intronENST00000542899ENST00000583087LATS2chr13

21634332

-MYLKchr3

123386033

-
intron-intronENST00000542899ENST00000583087LATS2chr13

21635485

-MYLKchr3

123386034

-
intron-intronENST00000542899ENST00000583087LATS2chr13

21635484

-MYLKchr3

123386034

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for LATS2-MYLK


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for LATS2-MYLK


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:21635485/:123386034)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LATS2

Q9NRM7

MYLK

Q86YV6

FUNCTION: Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in centrosome duplication, maintenance of mitotic fidelity and genomic stability. Negatively regulates G1/S transition by down-regulating cyclin E/CDK2 kinase activity. Negative regulator of the androgen receptor. Phosphorylates SNAI1 in the nucleus leading to its nuclear retention and stabilization, which enhances its epithelial-mesenchymal transition and tumor cell invasion/migration activities. This tumor-promoting activity is independent of its effects upon YAP1 or WWTR1/TAZ. {ECO:0000269|PubMed:10871863, ECO:0000269|PubMed:12853976, ECO:0000269|PubMed:15131260, ECO:0000269|PubMed:18158288, ECO:0000269|PubMed:21952048}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for LATS2-MYLK


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for LATS2-MYLK


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for LATS2-MYLK


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for LATS2-MYLK


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource