FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:LCOR-PDLIM1 (FusionGDB2 ID:44279)

Fusion Gene Summary for LCOR-PDLIM1

check button Fusion gene summary
Fusion gene informationFusion gene name: LCOR-PDLIM1
Fusion gene ID: 44279
HgeneTgene
Gene symbol

LCOR

PDLIM1

Gene ID

84458

9124

Gene nameligand dependent nuclear receptor corepressorPDZ and LIM domain 1
SynonymsC10orf12|MLR2CLIM1|CLP-36|CLP36|HEL-S-112|hCLIM1
Cytomap

10q24.1

10q23.33

Type of geneprotein-codingprotein-coding
Descriptionligand-dependent corepressormblk1-related protein 2PDZ and LIM domain protein 1LIM domain protein CLP-36carboxyl terminal LIM domain protein 1elfinepididymis secretory protein Li 112
Modification date2020031320200327
UniProtAcc

Q96JN0

.
Ensembl transtripts involved in fusion geneENST00000498444, ENST00000356016, 
ENST00000371097, ENST00000371103, 
ENST00000540664, 		ENST00000329399, 
ENST00000477757, 
Fusion gene scores* DoF score17 X 9 X 9=137710 X 5 X 6=300
# samples 1811
** MAII scorelog2(18/1377*10)=-2.93545974780529
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/300*10)=-1.44745897697122
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: LCOR [Title/Abstract] AND PDLIM1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointLCOR(98711953)-PDLIM1(97007123), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across LCOR (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PDLIM1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-A4PE-01ALCORchr10

98711953

+PDLIM1chr10

97007123

-


Top

Fusion Gene ORF analysis for LCOR-PDLIM1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000498444ENST00000329399LCORchr10

98711953

+PDLIM1chr10

97007123

-
3UTR-5UTRENST00000498444ENST00000477757LCORchr10

98711953

+PDLIM1chr10

97007123

-
5CDS-5UTRENST00000356016ENST00000477757LCORchr10

98711953

+PDLIM1chr10

97007123

-
5CDS-5UTRENST00000371097ENST00000477757LCORchr10

98711953

+PDLIM1chr10

97007123

-
5CDS-5UTRENST00000371103ENST00000477757LCORchr10

98711953

+PDLIM1chr10

97007123

-
5CDS-5UTRENST00000540664ENST00000477757LCORchr10

98711953

+PDLIM1chr10

97007123

-
In-frameENST00000356016ENST00000329399LCORchr10

98711953

+PDLIM1chr10

97007123

-
In-frameENST00000371097ENST00000329399LCORchr10

98711953

+PDLIM1chr10

97007123

-
In-frameENST00000371103ENST00000329399LCORchr10

98711953

+PDLIM1chr10

97007123

-
In-frameENST00000540664ENST00000329399LCORchr10

98711953

+PDLIM1chr10

97007123

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000540664LCORchr1098711953+ENST00000329399PDLIM1chr1097007123-16858751321331399
ENST00000371103LCORchr1098711953+ENST00000329399PDLIM1chr1097007123-16638531101309399
ENST00000356016LCORchr1098711953+ENST00000329399PDLIM1chr1097007123-17058951731351392
ENST00000371097LCORchr1098711953+ENST00000329399PDLIM1chr1097007123-1688878391334431

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000540664ENST00000329399LCORchr1098711953+PDLIM1chr1097007123-0.0110543450.98894566
ENST00000371103ENST00000329399LCORchr1098711953+PDLIM1chr1097007123-0.0099896140.9900103
ENST00000356016ENST00000329399LCORchr1098711953+PDLIM1chr1097007123-0.0114219830.98857796
ENST00000371097ENST00000329399LCORchr1098711953+PDLIM1chr1097007123-0.0117650070.988235

Top

Fusion Genomic Features for LCOR-PDLIM1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for LCOR-PDLIM1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:98711953/chr10:97007123)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LCOR

Q96JN0

.
FUNCTION: May act as transcription activator that binds DNA elements with the sequence 5'-CCCTATCGATCGATCTCTACCT-3' (By similarity). Repressor of ligand-dependent transcription activation by target nuclear receptors. Repressor of ligand-dependent transcription activation by ESR1, ESR2, NR3C1, PGR, RARA, RARB, RARG, RXRA and VDR. {ECO:0000250, ECO:0000269|PubMed:12535528}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgenePDLIM1chr10:98711953chr10:97007123ENST0000032939937258_317177330.0DomainLIM zinc-binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLCORchr10:98711953chr10:97007123ENST00000356016+78368_388110434.0DNA bindingH-T-H motif
HgeneLCORchr10:98711953chr10:97007123ENST00000371097+78368_388110434.0DNA bindingH-T-H motif
HgeneLCORchr10:98711953chr10:97007123ENST00000371103+78368_388110434.0DNA bindingH-T-H motif
HgeneLCORchr10:98711953chr10:97007123ENST00000540664+79368_388110407.0DNA bindingH-T-H motif
HgeneLCORchr10:98711953chr10:97007123ENST00000356016+78340_392110434.0DomainHTH psq-type
HgeneLCORchr10:98711953chr10:97007123ENST00000371097+78340_392110434.0DomainHTH psq-type
HgeneLCORchr10:98711953chr10:97007123ENST00000371103+78340_392110434.0DomainHTH psq-type
HgeneLCORchr10:98711953chr10:97007123ENST00000540664+79340_392110407.0DomainHTH psq-type
HgeneLCORchr10:98711953chr10:97007123ENST00000356016+78339_345110434.0MotifNuclear localization signal
HgeneLCORchr10:98711953chr10:97007123ENST00000371097+78339_345110434.0MotifNuclear localization signal
HgeneLCORchr10:98711953chr10:97007123ENST00000371103+78339_345110434.0MotifNuclear localization signal
HgeneLCORchr10:98711953chr10:97007123ENST00000540664+79339_345110407.0MotifNuclear localization signal
TgenePDLIM1chr10:98711953chr10:97007123ENST00000329399373_85177330.0DomainPDZ


Top

Fusion Gene Sequence for LCOR-PDLIM1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>44279_44279_1_LCOR-PDLIM1_LCOR_chr10_98711953_ENST00000356016_PDLIM1_chr10_97007123_ENST00000329399_length(transcript)=1705nt_BP=895nt
GTGCGAAGCGTGAGGTGGAGATGGGGGCGGAGGGAGCTGGAGCTGTCACAGTCCCCGGGTGCGCCTGACCGAGCCAAGTGGGGTGTCATG
GCCGCGGGGGGCAGCGGCTGCACTTCCTCAGCGGGCGGCGGTGGCCGGGGAGTTAATCCTCGACGCACGGGTCCCGTTTCCCTCTGTGCG
GCGGCCGGCGGGACCATAAGGGCTTAACTCATATATTTAACCCCCCTCCAAAAAGGTTTGAAAGTATTCTTGAAGGGCTGTTTGGACCTG
CATTATTAAAAGATCTCAGTTTATTTAAAGACTGTGAACCTGAAAGCATTTCTGATTGGACTTTTGATGAAAACTGTTTATTCTGTTGCT
TGAGAAGAGATAAAGTAAAGGGACACTTAGTCGGTCTGGATGAACCAGCTTCGGGAGCTGGGCAAGAAGCTCTGCTTAAACAAGAGCAAG
CAAAAATCATTCGATTCGAGAGACAAGCAGAAGAATTCCTCAATGCAGTCTTTTATAGAAAAGACAGTCCCTGGGTCTCCGACCCCAATA
TTCCCCTAGTGGCCCGTGAGATCATGCAGCGAATGATCCAACAATTTGCTGCTGAATATACCTCAAAAAATAGCTCTACTCAGGACCCCA
GCCAGCCCAATAGCACAAAGAACCAAAGCCTGCCGAAAGCATCTCCAGTCACCACCTCTCCCACGGCTGCAACTACTCAGAACCCTGTGC
TCAGCAAACTTCTCATGGCTGACCAAGACTCACCTCTGGACCTTACTGTCAGAAAGTCTCAGTCAGAACCTAGCGAACAAGACGGTGTAC
TTGATCTGTCCACTAAGAAAAGTCCATGTGCTGGCAGCACTTCCCTGAGCCACTCTCCAGGCTGCTCCAGTACTCAAGGGAACGGCTTAG
ACCATGCTCAGCCTCCAAGCAGCCTTGTCATCGACAAAGAATCTGAAGTTTACAAGATGCTTCAGGAGAAACAGGAGTTGAATGAGCCCC
CGAAACAGTCCACGTCTTTCTTGGTTTTGCAGGAAATCCTGGAGTCTGAAGAAAAAGGGGATCCCAACAAGCCCTCAGGATTCAGAAGTG
TTAAAGCTCCTGTCACTAAAGTGGCTGCGTCGATTGGAAATGCTCAGAAGTTGCCTATGTGTGACAAATGTGGCACTGGGATTGTTGGTG
TGTTTGTGAAGCTGCGGGACCGTCACCGCCACCCTGAGTGTTATGTGTGCACTGACTGTGGCACCAACCTGAAACAGAAGGGCCATTTCT
TTGTGGAGGATCAAATCTACTGTGAGAAGCATGCCCGGGAGCGAGTCACACCACCTGAGGGTTATGAAGTGGTCACTGTGTTCCCCAAGT
GAGCCAGCAGATCTGACCACTGTTCTCCAGCAGGCCTCTGCTGCAGCTTTTTCTCTCAGTGTTCTGGCCCTCTCCTCTCTTGAAAGTTCT
CTGCTTACTTTGGTTTTCCCTCTGCTTGTAAAACATTGAGTCCCCTCCCTGCCTTGGTTAATTGACTCACACCAGCTGTGCGATGCCCGC
TTTTACAATTAAAGGAAAACTGTTTTGTTCAGTGTCACCTTGTCAGCAACACTGTGTCCCTTCGCCCCACCGTTCTTCTCTGCTGCATTT

>44279_44279_1_LCOR-PDLIM1_LCOR_chr10_98711953_ENST00000356016_PDLIM1_chr10_97007123_ENST00000329399_length(amino acids)=392AA_BP=241
MCGGRRDHKGLTHIFNPPPKRFESILEGLFGPALLKDLSLFKDCEPESISDWTFDENCLFCCLRRDKVKGHLVGLDEPASGAGQEALLKQ
EQAKIIRFERQAEEFLNAVFYRKDSPWVSDPNIPLVAREIMQRMIQQFAAEYTSKNSSTQDPSQPNSTKNQSLPKASPVTTSPTAATTQN
PVLSKLLMADQDSPLDLTVRKSQSEPSEQDGVLDLSTKKSPCAGSTSLSHSPGCSSTQGNGLDHAQPPSSLVIDKESEVYKMLQEKQELN
EPPKQSTSFLVLQEILESEEKGDPNKPSGFRSVKAPVTKVAASIGNAQKLPMCDKCGTGIVGVFVKLRDRHRHPECYVCTDCGTNLKQKG

--------------------------------------------------------------
>44279_44279_2_LCOR-PDLIM1_LCOR_chr10_98711953_ENST00000371097_PDLIM1_chr10_97007123_ENST00000329399_length(transcript)=1688nt_BP=878nt
GGCGGAGGGAGCTGGAGCTGTCACAGTCCCCGGGTGCGCCTGACCGAGCCAAGTGGGGTGTCATGGCCGCGGGGGGCAGCGGCTGCACTT
CCTCAGCGGGCGGCGGTGGCCGGGGAGTTAATCCTCGACGCACGGGTCGGTGTGTCCCGTTTCCCTCTGTGCGGCGGCCGGCGGGACCAT
AAGGGCTTAACTCATATATTTAACCCCCCTCCAAAAAGGTTTGAAAGTATTCTTGAAGGGCTGTTTGGACCTGCATTATTAAAAGATCTC
AGTTTATTTAAAGACTGTGAACCTGAAAGCATTTCTGATTGGACTTTTGATGAAAACTGTTTATTCTGTTGCTTGAGAAGAGATAAAGTA
AAGGGACACTTAGTCGGTCTGGATGAACCAGCTTCGGGAGCTGGGCAAGAAGCTCTGCTTAAACAAGAGCAAGCAAAAATCATTCGATTC
GAGAGACAAGCAGAAGAATTCCTCAATGCAGTCTTTTATAGAAAAGACAGTCCCTGGGTCTCCGACCCCAATATTCCCCTAGTGGCCCGT
GAGATCATGCAGCGAATGATCCAACAATTTGCTGCTGAATATACCTCAAAAAATAGCTCTACTCAGGACCCCAGCCAGCCCAATAGCACA
AAGAACCAAAGCCTGCCGAAAGCATCTCCAGTCACCACCTCTCCCACGGCTGCAACTACTCAGAACCCTGTGCTCAGCAAACTTCTCATG
GCTGACCAAGACTCACCTCTGGACCTTACTGTCAGAAAGTCTCAGTCAGAACCTAGCGAACAAGACGGTGTACTTGATCTGTCCACTAAG
AAAAGTCCATGTGCTGGCAGCACTTCCCTGAGCCACTCTCCAGGCTGCTCCAGTACTCAAGGGAACGGCTTAGACCATGCTCAGCCTCCA
AGCAGCCTTGTCATCGACAAAGAATCTGAAGTTTACAAGATGCTTCAGGAGAAACAGGAGTTGAATGAGCCCCCGAAACAGTCCACGTCT
TTCTTGGTTTTGCAGGAAATCCTGGAGTCTGAAGAAAAAGGGGATCCCAACAAGCCCTCAGGATTCAGAAGTGTTAAAGCTCCTGTCACT
AAAGTGGCTGCGTCGATTGGAAATGCTCAGAAGTTGCCTATGTGTGACAAATGTGGCACTGGGATTGTTGGTGTGTTTGTGAAGCTGCGG
GACCGTCACCGCCACCCTGAGTGTTATGTGTGCACTGACTGTGGCACCAACCTGAAACAGAAGGGCCATTTCTTTGTGGAGGATCAAATC
TACTGTGAGAAGCATGCCCGGGAGCGAGTCACACCACCTGAGGGTTATGAAGTGGTCACTGTGTTCCCCAAGTGAGCCAGCAGATCTGAC
CACTGTTCTCCAGCAGGCCTCTGCTGCAGCTTTTTCTCTCAGTGTTCTGGCCCTCTCCTCTCTTGAAAGTTCTCTGCTTACTTTGGTTTT
CCCTCTGCTTGTAAAACATTGAGTCCCCTCCCTGCCTTGGTTAATTGACTCACACCAGCTGTGCGATGCCCGCTTTTACAATTAAAGGAA
AACTGTTTTGTTCAGTGTCACCTTGTCAGCAACACTGTGTCCCTTCGCCCCACCGTTCTTCTCTGCTGCATTTGGACATCAGCCAAATTT

>44279_44279_2_LCOR-PDLIM1_LCOR_chr10_98711953_ENST00000371097_PDLIM1_chr10_97007123_ENST00000329399_length(amino acids)=431AA_BP=280
MTEPSGVSWPRGAAAALPQRAAVAGELILDARVGVSRFPLCGGRRDHKGLTHIFNPPPKRFESILEGLFGPALLKDLSLFKDCEPESISD
WTFDENCLFCCLRRDKVKGHLVGLDEPASGAGQEALLKQEQAKIIRFERQAEEFLNAVFYRKDSPWVSDPNIPLVAREIMQRMIQQFAAE
YTSKNSSTQDPSQPNSTKNQSLPKASPVTTSPTAATTQNPVLSKLLMADQDSPLDLTVRKSQSEPSEQDGVLDLSTKKSPCAGSTSLSHS
PGCSSTQGNGLDHAQPPSSLVIDKESEVYKMLQEKQELNEPPKQSTSFLVLQEILESEEKGDPNKPSGFRSVKAPVTKVAASIGNAQKLP

--------------------------------------------------------------
>44279_44279_3_LCOR-PDLIM1_LCOR_chr10_98711953_ENST00000371103_PDLIM1_chr10_97007123_ENST00000329399_length(transcript)=1663nt_BP=853nt
GGGCCGGGCGGGCGGCAGAAGATGGCGAGGGTGTGTAGGCGGCAGCAATGCTCCGTTGAGAGACGCGGCTTTCGGCAAGAACTGGATTCG
TGGCGCCACAAGCTCATTCACTGTGTAGGTCCCGTTTCCCTCTGTGCGGCGGCCGGCGGGACCATAAGGGCTTAACTCATATATTTAACC
CCCCTCCAAAAAGGTTTGAAAGTATTCTTGAAGGGCTGTTTGGACCTGCATTATTAAAAGATCTCAGTTTATTTAAAGACTGTGAACCTG
AAAGCATTTCTGATTGGACTTTTGATGAAAACTGTTTATTCTGTTGCTTGAGAAGAGATAAAGTAAAGGGACACTTAGTCGGTCTGGATG
AACCAGCTTCGGGAGCTGGGCAAGAAGCTCTGCTTAAACAAGAGCAAGCAAAAATCATTCGATTCGAGAGACAAGCAGAAGAATTCCTCA
ATGCAGTCTTTTATAGAAAAGACAGTCCCTGGGTCTCCGACCCCAATATTCCCCTAGTGGCCCGTGAGATCATGCAGCGAATGATCCAAC
AATTTGCTGCTGAATATACCTCAAAAAATAGCTCTACTCAGGACCCCAGCCAGCCCAATAGCACAAAGAACCAAAGCCTGCCGAAAGCAT
CTCCAGTCACCACCTCTCCCACGGCTGCAACTACTCAGAACCCTGTGCTCAGCAAACTTCTCATGGCTGACCAAGACTCACCTCTGGACC
TTACTGTCAGAAAGTCTCAGTCAGAACCTAGCGAACAAGACGGTGTACTTGATCTGTCCACTAAGAAAAGTCCATGTGCTGGCAGCACTT
CCCTGAGCCACTCTCCAGGCTGCTCCAGTACTCAAGGGAACGGCTTAGACCATGCTCAGCCTCCAAGCAGCCTTGTCATCGACAAAGAAT
CTGAAGTTTACAAGATGCTTCAGGAGAAACAGGAGTTGAATGAGCCCCCGAAACAGTCCACGTCTTTCTTGGTTTTGCAGGAAATCCTGG
AGTCTGAAGAAAAAGGGGATCCCAACAAGCCCTCAGGATTCAGAAGTGTTAAAGCTCCTGTCACTAAAGTGGCTGCGTCGATTGGAAATG
CTCAGAAGTTGCCTATGTGTGACAAATGTGGCACTGGGATTGTTGGTGTGTTTGTGAAGCTGCGGGACCGTCACCGCCACCCTGAGTGTT
ATGTGTGCACTGACTGTGGCACCAACCTGAAACAGAAGGGCCATTTCTTTGTGGAGGATCAAATCTACTGTGAGAAGCATGCCCGGGAGC
GAGTCACACCACCTGAGGGTTATGAAGTGGTCACTGTGTTCCCCAAGTGAGCCAGCAGATCTGACCACTGTTCTCCAGCAGGCCTCTGCT
GCAGCTTTTTCTCTCAGTGTTCTGGCCCTCTCCTCTCTTGAAAGTTCTCTGCTTACTTTGGTTTTCCCTCTGCTTGTAAAACATTGAGTC
CCCTCCCTGCCTTGGTTAATTGACTCACACCAGCTGTGCGATGCCCGCTTTTACAATTAAAGGAAAACTGTTTTGTTCAGTGTCACCTTG
TCAGCAACACTGTGTCCCTTCGCCCCACCGTTCTTCTCTGCTGCATTTGGACATCAGCCAAATTTGAACCCAATCAAATATAACGTGTCT

>44279_44279_3_LCOR-PDLIM1_LCOR_chr10_98711953_ENST00000371103_PDLIM1_chr10_97007123_ENST00000329399_length(amino acids)=399AA_BP=248
MCRSRFPLCGGRRDHKGLTHIFNPPPKRFESILEGLFGPALLKDLSLFKDCEPESISDWTFDENCLFCCLRRDKVKGHLVGLDEPASGAG
QEALLKQEQAKIIRFERQAEEFLNAVFYRKDSPWVSDPNIPLVAREIMQRMIQQFAAEYTSKNSSTQDPSQPNSTKNQSLPKASPVTTSP
TAATTQNPVLSKLLMADQDSPLDLTVRKSQSEPSEQDGVLDLSTKKSPCAGSTSLSHSPGCSSTQGNGLDHAQPPSSLVIDKESEVYKML
QEKQELNEPPKQSTSFLVLQEILESEEKGDPNKPSGFRSVKAPVTKVAASIGNAQKLPMCDKCGTGIVGVFVKLRDRHRHPECYVCTDCG

--------------------------------------------------------------
>44279_44279_4_LCOR-PDLIM1_LCOR_chr10_98711953_ENST00000540664_PDLIM1_chr10_97007123_ENST00000329399_length(transcript)=1685nt_BP=875nt
GCGCGGGGCCGCGGCGGAGGCTGGGCCGGGCGGGCGGCAGAAGATGGCGAGGGTGTGTAGGCGGCAGCAATGCTCCGTTGAGAGACGCGG
CTTTCGGCAAGAACTGGATTCGTGGCGCCACAAGCTCATTCACTGTGTAGGTCCCGTTTCCCTCTGTGCGGCGGCCGGCGGGACCATAAG
GGCTTAACTCATATATTTAACCCCCCTCCAAAAAGGTTTGAAAGTATTCTTGAAGGGCTGTTTGGACCTGCATTATTAAAAGATCTCAGT
TTATTTAAAGACTGTGAACCTGAAAGCATTTCTGATTGGACTTTTGATGAAAACTGTTTATTCTGTTGCTTGAGAAGAGATAAAGTAAAG
GGACACTTAGTCGGTCTGGATGAACCAGCTTCGGGAGCTGGGCAAGAAGCTCTGCTTAAACAAGAGCAAGCAAAAATCATTCGATTCGAG
AGACAAGCAGAAGAATTCCTCAATGCAGTCTTTTATAGAAAAGACAGTCCCTGGGTCTCCGACCCCAATATTCCCCTAGTGGCCCGTGAG
ATCATGCAGCGAATGATCCAACAATTTGCTGCTGAATATACCTCAAAAAATAGCTCTACTCAGGACCCCAGCCAGCCCAATAGCACAAAG
AACCAAAGCCTGCCGAAAGCATCTCCAGTCACCACCTCTCCCACGGCTGCAACTACTCAGAACCCTGTGCTCAGCAAACTTCTCATGGCT
GACCAAGACTCACCTCTGGACCTTACTGTCAGAAAGTCTCAGTCAGAACCTAGCGAACAAGACGGTGTACTTGATCTGTCCACTAAGAAA
AGTCCATGTGCTGGCAGCACTTCCCTGAGCCACTCTCCAGGCTGCTCCAGTACTCAAGGGAACGGCTTAGACCATGCTCAGCCTCCAAGC
AGCCTTGTCATCGACAAAGAATCTGAAGTTTACAAGATGCTTCAGGAGAAACAGGAGTTGAATGAGCCCCCGAAACAGTCCACGTCTTTC
TTGGTTTTGCAGGAAATCCTGGAGTCTGAAGAAAAAGGGGATCCCAACAAGCCCTCAGGATTCAGAAGTGTTAAAGCTCCTGTCACTAAA
GTGGCTGCGTCGATTGGAAATGCTCAGAAGTTGCCTATGTGTGACAAATGTGGCACTGGGATTGTTGGTGTGTTTGTGAAGCTGCGGGAC
CGTCACCGCCACCCTGAGTGTTATGTGTGCACTGACTGTGGCACCAACCTGAAACAGAAGGGCCATTTCTTTGTGGAGGATCAAATCTAC
TGTGAGAAGCATGCCCGGGAGCGAGTCACACCACCTGAGGGTTATGAAGTGGTCACTGTGTTCCCCAAGTGAGCCAGCAGATCTGACCAC
TGTTCTCCAGCAGGCCTCTGCTGCAGCTTTTTCTCTCAGTGTTCTGGCCCTCTCCTCTCTTGAAAGTTCTCTGCTTACTTTGGTTTTCCC
TCTGCTTGTAAAACATTGAGTCCCCTCCCTGCCTTGGTTAATTGACTCACACCAGCTGTGCGATGCCCGCTTTTACAATTAAAGGAAAAC
TGTTTTGTTCAGTGTCACCTTGTCAGCAACACTGTGTCCCTTCGCCCCACCGTTCTTCTCTGCTGCATTTGGACATCAGCCAAATTTGAA

>44279_44279_4_LCOR-PDLIM1_LCOR_chr10_98711953_ENST00000540664_PDLIM1_chr10_97007123_ENST00000329399_length(amino acids)=399AA_BP=248
MCRSRFPLCGGRRDHKGLTHIFNPPPKRFESILEGLFGPALLKDLSLFKDCEPESISDWTFDENCLFCCLRRDKVKGHLVGLDEPASGAG
QEALLKQEQAKIIRFERQAEEFLNAVFYRKDSPWVSDPNIPLVAREIMQRMIQQFAAEYTSKNSSTQDPSQPNSTKNQSLPKASPVTTSP
TAATTQNPVLSKLLMADQDSPLDLTVRKSQSEPSEQDGVLDLSTKKSPCAGSTSLSHSPGCSSTQGNGLDHAQPPSSLVIDKESEVYKML
QEKQELNEPPKQSTSFLVLQEILESEEKGDPNKPSGFRSVKAPVTKVAASIGNAQKLPMCDKCGTGIVGVFVKLRDRHRHPECYVCTDCG

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for LCOR-PDLIM1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for LCOR-PDLIM1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for LCOR-PDLIM1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource