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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:ABI1-CDYL2 (FusionGDB2 ID:443)

Fusion Gene Summary for ABI1-CDYL2

Fusion gene summary

Fusion gene information	Fusion gene name: ABI1-CDYL2
	Fusion gene ID: 443
		Hgene	Tgene
	Gene symbol	ABI1	CDYL2
	Gene ID	10006	124359
	Gene name	abl interactor 1	chromodomain Y like 2
	Synonyms	ABI-1\|ABLBP4\|E3B1\|NAP1BP\|SSH3BP\|SSH3BP1	PCCP1
	Cytomap	10p12.1	16q23.2
	Type of gene	protein-coding	protein-coding
	Description	abl interactor 1Abelson interactor 1Abl-interactor protein 1 longabl-binding protein 4eps8 SH3 domain-binding proteininteractor protein AblBP4nap1 binding proteinspectrin SH3 domain-binding protein 1	chromodomain Y-like protein 2CDY-like 2chromodomain protein, Y-like 2prostate cancer candidate protein 1, PCCP1
	Modification date	20200327	20200318
	UniProtAcc	Q8IZP0	Q8N8U2
	Ensembl transtripts involved in fusion gene	ENST00000346832, ENST00000355394, ENST00000359188, ENST00000376134, ENST00000376137, ENST00000376138, ENST00000376139, ENST00000376140, ENST00000376142, ENST00000376160, ENST00000376166, ENST00000376170, ENST00000473481, ENST00000490841, ENST00000536334,	ENST00000562753, ENST00000562812, ENST00000563890, ENST00000566173, ENST00000570137,
Fusion gene scores	* DoF score	15 X 10 X 8=1200	9 X 9 X 3=243
	# samples	15	11
	** MAII score	log2(15/1200*10)=-3 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(11/243*10)=-1.14345279008112 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: ABI1 [Title/Abstract] AND CDYL2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	ABI1(27036740)-CDYL2(80816426), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	ABI1	GO:0018108	peptidyl-tyrosine phosphorylation	17101133

Fusion gene breakpoints across ABI1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across CDYL2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS5.0	N/A	CF122572	ABI1	chr10	27036740	-	CDYL2	chr16	80816426	+

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Fusion Gene ORF analysis for ABI1-CDYL2

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-intron	ENST00000346832	ENST00000562753	ABI1	chr10	27036740	-	CDYL2	chr16	80816426	+
intron-intron	ENST00000346832	ENST00000562812	ABI1	chr10	27036740	-	CDYL2	chr16	80816426	+
intron-intron	ENST00000346832	ENST00000563890	ABI1	chr10	27036740	-	CDYL2	chr16	80816426	+
intron-intron	ENST00000346832	ENST00000566173	ABI1	chr10	27036740	-	CDYL2	chr16	80816426	+
intron-intron	ENST00000346832	ENST00000570137	ABI1	chr10	27036740	-	CDYL2	chr16	80816426	+
intron-intron	ENST00000355394	ENST00000562753	ABI1	chr10	27036740	-	CDYL2	chr16	80816426	+
intron-intron	ENST00000355394	ENST00000562812	ABI1	chr10	27036740	-	CDYL2	chr16	80816426	+
intron-intron	ENST00000355394	ENST00000563890	ABI1	chr10	27036740	-	CDYL2	chr16	80816426	+
intron-intron	ENST00000355394	ENST00000566173	ABI1	chr10	27036740	-	CDYL2	chr16	80816426	+
intron-intron	ENST00000355394	ENST00000570137	ABI1	chr10	27036740	-	CDYL2	chr16	80816426	+
intron-intron	ENST00000359188	ENST00000562753	ABI1	chr10	27036740	-	CDYL2	chr16	80816426	+
intron-intron	ENST00000359188	ENST00000562812	ABI1	chr10	27036740	-	CDYL2	chr16	80816426	+
intron-intron	ENST00000359188	ENST00000563890	ABI1	chr10	27036740	-	CDYL2	chr16	80816426	+
intron-intron	ENST00000359188	ENST00000566173	ABI1	chr10	27036740	-	CDYL2	chr16	80816426	+
intron-intron	ENST00000359188	ENST00000570137	ABI1	chr10	27036740	-	CDYL2	chr16	80816426	+
intron-intron	ENST00000376134	ENST00000562753	ABI1	chr10	27036740	-	CDYL2	chr16	80816426	+
intron-intron	ENST00000376134	ENST00000562812	ABI1	chr10	27036740	-	CDYL2	chr16	80816426	+
intron-intron	ENST00000376134	ENST00000563890	ABI1	chr10	27036740	-	CDYL2	chr16	80816426	+
intron-intron	ENST00000376134	ENST00000566173	ABI1	chr10	27036740	-	CDYL2	chr16	80816426	+
intron-intron	ENST00000376134	ENST00000570137	ABI1	chr10	27036740	-	CDYL2	chr16	80816426	+
intron-intron	ENST00000376137	ENST00000562753	ABI1	chr10	27036740	-	CDYL2	chr16	80816426	+
intron-intron	ENST00000376137	ENST00000562812	ABI1	chr10	27036740	-	CDYL2	chr16	80816426	+
intron-intron	ENST00000376137	ENST00000563890	ABI1	chr10	27036740	-	CDYL2	chr16	80816426	+
intron-intron	ENST00000376137	ENST00000566173	ABI1	chr10	27036740	-	CDYL2	chr16	80816426	+
intron-intron	ENST00000376137	ENST00000570137	ABI1	chr10	27036740	-	CDYL2	chr16	80816426	+
intron-intron	ENST00000376138	ENST00000562753	ABI1	chr10	27036740	-	CDYL2	chr16	80816426	+
intron-intron	ENST00000376138	ENST00000562812	ABI1	chr10	27036740	-	CDYL2	chr16	80816426	+
intron-intron	ENST00000376138	ENST00000563890	ABI1	chr10	27036740	-	CDYL2	chr16	80816426	+
intron-intron	ENST00000376138	ENST00000566173	ABI1	chr10	27036740	-	CDYL2	chr16	80816426	+
intron-intron	ENST00000376138	ENST00000570137	ABI1	chr10	27036740	-	CDYL2	chr16	80816426	+
intron-intron	ENST00000376139	ENST00000562753	ABI1	chr10	27036740	-	CDYL2	chr16	80816426	+
intron-intron	ENST00000376139	ENST00000562812	ABI1	chr10	27036740	-	CDYL2	chr16	80816426	+
intron-intron	ENST00000376139	ENST00000563890	ABI1	chr10	27036740	-	CDYL2	chr16	80816426	+
intron-intron	ENST00000376139	ENST00000566173	ABI1	chr10	27036740	-	CDYL2	chr16	80816426	+
intron-intron	ENST00000376139	ENST00000570137	ABI1	chr10	27036740	-	CDYL2	chr16	80816426	+
intron-intron	ENST00000376140	ENST00000562753	ABI1	chr10	27036740	-	CDYL2	chr16	80816426	+
intron-intron	ENST00000376140	ENST00000562812	ABI1	chr10	27036740	-	CDYL2	chr16	80816426	+
intron-intron	ENST00000376140	ENST00000563890	ABI1	chr10	27036740	-	CDYL2	chr16	80816426	+
intron-intron	ENST00000376140	ENST00000566173	ABI1	chr10	27036740	-	CDYL2	chr16	80816426	+
intron-intron	ENST00000376140	ENST00000570137	ABI1	chr10	27036740	-	CDYL2	chr16	80816426	+
intron-intron	ENST00000376142	ENST00000562753	ABI1	chr10	27036740	-	CDYL2	chr16	80816426	+
intron-intron	ENST00000376142	ENST00000562812	ABI1	chr10	27036740	-	CDYL2	chr16	80816426	+
intron-intron	ENST00000376142	ENST00000563890	ABI1	chr10	27036740	-	CDYL2	chr16	80816426	+
intron-intron	ENST00000376142	ENST00000566173	ABI1	chr10	27036740	-	CDYL2	chr16	80816426	+
intron-intron	ENST00000376142	ENST00000570137	ABI1	chr10	27036740	-	CDYL2	chr16	80816426	+
intron-intron	ENST00000376160	ENST00000562753	ABI1	chr10	27036740	-	CDYL2	chr16	80816426	+
intron-intron	ENST00000376160	ENST00000562812	ABI1	chr10	27036740	-	CDYL2	chr16	80816426	+
intron-intron	ENST00000376160	ENST00000563890	ABI1	chr10	27036740	-	CDYL2	chr16	80816426	+
intron-intron	ENST00000376160	ENST00000566173	ABI1	chr10	27036740	-	CDYL2	chr16	80816426	+
intron-intron	ENST00000376160	ENST00000570137	ABI1	chr10	27036740	-	CDYL2	chr16	80816426	+
intron-intron	ENST00000376166	ENST00000562753	ABI1	chr10	27036740	-	CDYL2	chr16	80816426	+
intron-intron	ENST00000376166	ENST00000562812	ABI1	chr10	27036740	-	CDYL2	chr16	80816426	+
intron-intron	ENST00000376166	ENST00000563890	ABI1	chr10	27036740	-	CDYL2	chr16	80816426	+
intron-intron	ENST00000376166	ENST00000566173	ABI1	chr10	27036740	-	CDYL2	chr16	80816426	+
intron-intron	ENST00000376166	ENST00000570137	ABI1	chr10	27036740	-	CDYL2	chr16	80816426	+
intron-intron	ENST00000376170	ENST00000562753	ABI1	chr10	27036740	-	CDYL2	chr16	80816426	+
intron-intron	ENST00000376170	ENST00000562812	ABI1	chr10	27036740	-	CDYL2	chr16	80816426	+
intron-intron	ENST00000376170	ENST00000563890	ABI1	chr10	27036740	-	CDYL2	chr16	80816426	+
intron-intron	ENST00000376170	ENST00000566173	ABI1	chr10	27036740	-	CDYL2	chr16	80816426	+
intron-intron	ENST00000376170	ENST00000570137	ABI1	chr10	27036740	-	CDYL2	chr16	80816426	+
intron-intron	ENST00000473481	ENST00000562753	ABI1	chr10	27036740	-	CDYL2	chr16	80816426	+
intron-intron	ENST00000473481	ENST00000562812	ABI1	chr10	27036740	-	CDYL2	chr16	80816426	+
intron-intron	ENST00000473481	ENST00000563890	ABI1	chr10	27036740	-	CDYL2	chr16	80816426	+
intron-intron	ENST00000473481	ENST00000566173	ABI1	chr10	27036740	-	CDYL2	chr16	80816426	+
intron-intron	ENST00000473481	ENST00000570137	ABI1	chr10	27036740	-	CDYL2	chr16	80816426	+
intron-intron	ENST00000490841	ENST00000562753	ABI1	chr10	27036740	-	CDYL2	chr16	80816426	+
intron-intron	ENST00000490841	ENST00000562812	ABI1	chr10	27036740	-	CDYL2	chr16	80816426	+
intron-intron	ENST00000490841	ENST00000563890	ABI1	chr10	27036740	-	CDYL2	chr16	80816426	+
intron-intron	ENST00000490841	ENST00000566173	ABI1	chr10	27036740	-	CDYL2	chr16	80816426	+
intron-intron	ENST00000490841	ENST00000570137	ABI1	chr10	27036740	-	CDYL2	chr16	80816426	+
intron-intron	ENST00000536334	ENST00000562753	ABI1	chr10	27036740	-	CDYL2	chr16	80816426	+
intron-intron	ENST00000536334	ENST00000562812	ABI1	chr10	27036740	-	CDYL2	chr16	80816426	+
intron-intron	ENST00000536334	ENST00000563890	ABI1	chr10	27036740	-	CDYL2	chr16	80816426	+
intron-intron	ENST00000536334	ENST00000566173	ABI1	chr10	27036740	-	CDYL2	chr16	80816426	+
intron-intron	ENST00000536334	ENST00000570137	ABI1	chr10	27036740	-	CDYL2	chr16	80816426	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Genomic Features for ABI1-CDYL2

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ABI1-CDYL2

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:27036740/:80816426)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ABI1 Q8IZP0	CDYL2 Q8N8U2
FUNCTION: May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. May play a role in regulation of EGF-induced Erk pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1/c-Abl-mediated phosphorylation of ENAH. Recruits WASF1 to lamellipodia and there seems to regulate WASF1 protein level. In brain, seems to regulate the dendritic outgrowth and branching as well as to determine the shape and number of synaptic contacts of developing neurons. {ECO:0000269\|PubMed:11003655, ECO:0000269\|PubMed:18328268}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for ABI1-CDYL2

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for ABI1-CDYL2

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for ABI1-CDYL2

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for ABI1-CDYL2

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source