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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:LDLR-LRPAP1 (FusionGDB2 ID:44413)

Fusion Gene Summary for LDLR-LRPAP1

check button Fusion gene summary
Fusion gene informationFusion gene name: LDLR-LRPAP1
Fusion gene ID: 44413
HgeneTgene
Gene symbol

LDLR

LRPAP1

Gene ID

3949

4043

Gene namelow density lipoprotein receptorLDL receptor related protein associated protein 1
SynonymsFH|FHC|FHCL1|LDLCQ2A2MRAP|A2RAP|HBP44|MRAP|MYP23|RAP|alpha-2-MRAP
Cytomap

19p13.2

4p16.3

Type of geneprotein-codingprotein-coding
Descriptionlow-density lipoprotein receptorLDL receptorlow-density lipoprotein receptor class A domain-containing protein 3alpha-2-macroglobulin receptor-associated protein39 kDa receptor-associated proteinlow density lipoprotein receptor-related protein associated protein 1low density lipoprotein-related protein-associated protein 1 (alpha-2-macroglobulin receptor-associa
Modification date2020032220200327
UniProtAcc.

P30533

Ensembl transtripts involved in fusion geneENST00000455727, ENST00000535915, 
ENST00000545707, ENST00000557933, 
ENST00000558013, ENST00000558518, 
ENST00000560628, 		ENST00000296325, 
ENST00000500728, 
Fusion gene scores* DoF score23 X 17 X 15=58657 X 7 X 3=147
# samples 337
** MAII scorelog2(33/5865*10)=-4.15159317867005
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/147*10)=-1.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: LDLR [Title/Abstract] AND LRPAP1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointLDLR(11200291)-LRPAP1(3514763), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneLRPAP1

GO:0010916

negative regulation of very-low-density lipoprotein particle clearance

8083232

TgeneLRPAP1

GO:0032091

negative regulation of protein binding

8083232

TgeneLRPAP1

GO:0048259

regulation of receptor-mediated endocytosis

7774585


check buttonFusion gene breakpoints across LDLR (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across LRPAP1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-04-1348-01ALDLRchr19

11200291

+LRPAP1chr4

3514763

-


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Fusion Gene ORF analysis for LDLR-LRPAP1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000455727ENST00000296325LDLRchr19

11200291

+LRPAP1chr4

3514763

-
5CDS-5UTRENST00000535915ENST00000296325LDLRchr19

11200291

+LRPAP1chr4

3514763

-
5CDS-5UTRENST00000545707ENST00000296325LDLRchr19

11200291

+LRPAP1chr4

3514763

-
5CDS-5UTRENST00000557933ENST00000296325LDLRchr19

11200291

+LRPAP1chr4

3514763

-
5CDS-5UTRENST00000558013ENST00000296325LDLRchr19

11200291

+LRPAP1chr4

3514763

-
5CDS-5UTRENST00000558518ENST00000296325LDLRchr19

11200291

+LRPAP1chr4

3514763

-
In-frameENST00000455727ENST00000500728LDLRchr19

11200291

+LRPAP1chr4

3514763

-
In-frameENST00000535915ENST00000500728LDLRchr19

11200291

+LRPAP1chr4

3514763

-
In-frameENST00000545707ENST00000500728LDLRchr19

11200291

+LRPAP1chr4

3514763

-
In-frameENST00000557933ENST00000500728LDLRchr19

11200291

+LRPAP1chr4

3514763

-
In-frameENST00000558013ENST00000500728LDLRchr19

11200291

+LRPAP1chr4

3514763

-
In-frameENST00000558518ENST00000500728LDLRchr19

11200291

+LRPAP1chr4

3514763

-
intron-3CDSENST00000560628ENST00000500728LDLRchr19

11200291

+LRPAP1chr4

3514763

-
intron-5UTRENST00000560628ENST00000296325LDLRchr19

11200291

+LRPAP1chr4

3514763

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000558518LDLRchr1911200291+ENST00000500728LRPAP1chr43514763-69152541651986221
ENST00000557933LDLRchr1911200291+ENST00000500728LRPAP1chr43514763-68151541551886221
ENST00000455727LDLRchr1911200291+ENST00000500728LRPAP1chr43514763-68141531550885221
ENST00000535915LDLRchr1911200291+ENST00000500728LRPAP1chr43514763-68141531550885221
ENST00000545707LDLRchr1911200291+ENST00000500728LRPAP1chr43514763-68141531550885221
ENST00000558013LDLRchr1911200291+ENST00000500728LRPAP1chr43514763-67991381535870221

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000558518ENST00000500728LDLRchr1911200291+LRPAP1chr43514763-0.56294890.4370511
ENST00000557933ENST00000500728LDLRchr1911200291+LRPAP1chr43514763-0.567203940.43279606
ENST00000455727ENST00000500728LDLRchr1911200291+LRPAP1chr43514763-0.56654140.4334586
ENST00000535915ENST00000500728LDLRchr1911200291+LRPAP1chr43514763-0.56654140.4334586
ENST00000545707ENST00000500728LDLRchr1911200291+LRPAP1chr43514763-0.56654140.4334586
ENST00000558013ENST00000500728LDLRchr1911200291+LRPAP1chr43514763-0.565289560.43471044

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Fusion Genomic Features for LDLR-LRPAP1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for LDLR-LRPAP1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:11200291/chr4:3514763)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.LRPAP1

P30533

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Molecular chaperone for LDL receptor-related proteins that may regulate their ligand binding activity along the secretory pathway. {ECO:0000269|PubMed:32296178, ECO:0000269|PubMed:7774585}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneLRPAP1chr19:11200291chr4:3514763ENST0000050072868354_357337358.0MotifPrevents secretion from ER

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLDLRchr19:11200291chr4:3514763ENST00000455727+116107_14522693.0DomainLDL-receptor class A 3
HgeneLDLRchr19:11200291chr4:3514763ENST00000455727+116146_18622693.0DomainLDL-receptor class A 4
HgeneLDLRchr19:11200291chr4:3514763ENST00000455727+116195_23322693.0DomainLDL-receptor class A 5
HgeneLDLRchr19:11200291chr4:3514763ENST00000455727+116234_27222693.0DomainLDL-receptor class A 6
HgeneLDLRchr19:11200291chr4:3514763ENST00000455727+11625_6522693.0DomainLDL-receptor class A 1
HgeneLDLRchr19:11200291chr4:3514763ENST00000455727+116274_31322693.0DomainLDL-receptor class A 7
HgeneLDLRchr19:11200291chr4:3514763ENST00000455727+116314_35322693.0DomainEGF-like 1
HgeneLDLRchr19:11200291chr4:3514763ENST00000455727+116354_39322693.0DomainEGF-like 2%3B calcium-binding
HgeneLDLRchr19:11200291chr4:3514763ENST00000455727+116663_71222693.0DomainEGF-like 3
HgeneLDLRchr19:11200291chr4:3514763ENST00000455727+11666_10622693.0DomainLDL-receptor class A 2
HgeneLDLRchr19:11200291chr4:3514763ENST00000535915+117107_14522820.0DomainLDL-receptor class A 3
HgeneLDLRchr19:11200291chr4:3514763ENST00000535915+117146_18622820.0DomainLDL-receptor class A 4
HgeneLDLRchr19:11200291chr4:3514763ENST00000535915+117195_23322820.0DomainLDL-receptor class A 5
HgeneLDLRchr19:11200291chr4:3514763ENST00000535915+117234_27222820.0DomainLDL-receptor class A 6
HgeneLDLRchr19:11200291chr4:3514763ENST00000535915+11725_6522820.0DomainLDL-receptor class A 1
HgeneLDLRchr19:11200291chr4:3514763ENST00000535915+117274_31322820.0DomainLDL-receptor class A 7
HgeneLDLRchr19:11200291chr4:3514763ENST00000535915+117314_35322820.0DomainEGF-like 1
HgeneLDLRchr19:11200291chr4:3514763ENST00000535915+117354_39322820.0DomainEGF-like 2%3B calcium-binding
HgeneLDLRchr19:11200291chr4:3514763ENST00000535915+117663_71222820.0DomainEGF-like 3
HgeneLDLRchr19:11200291chr4:3514763ENST00000535915+11766_10622820.0DomainLDL-receptor class A 2
HgeneLDLRchr19:11200291chr4:3514763ENST00000545707+116107_14522683.0DomainLDL-receptor class A 3
HgeneLDLRchr19:11200291chr4:3514763ENST00000545707+116146_18622683.0DomainLDL-receptor class A 4
HgeneLDLRchr19:11200291chr4:3514763ENST00000545707+116195_23322683.0DomainLDL-receptor class A 5
HgeneLDLRchr19:11200291chr4:3514763ENST00000545707+116234_27222683.0DomainLDL-receptor class A 6
HgeneLDLRchr19:11200291chr4:3514763ENST00000545707+11625_6522683.0DomainLDL-receptor class A 1
HgeneLDLRchr19:11200291chr4:3514763ENST00000545707+116274_31322683.0DomainLDL-receptor class A 7
HgeneLDLRchr19:11200291chr4:3514763ENST00000545707+116314_35322683.0DomainEGF-like 1
HgeneLDLRchr19:11200291chr4:3514763ENST00000545707+116354_39322683.0DomainEGF-like 2%3B calcium-binding
HgeneLDLRchr19:11200291chr4:3514763ENST00000545707+116663_71222683.0DomainEGF-like 3
HgeneLDLRchr19:11200291chr4:3514763ENST00000545707+11666_10622683.0DomainLDL-receptor class A 2
HgeneLDLRchr19:11200291chr4:3514763ENST00000558013+118107_14522859.0DomainLDL-receptor class A 3
HgeneLDLRchr19:11200291chr4:3514763ENST00000558013+118146_18622859.0DomainLDL-receptor class A 4
HgeneLDLRchr19:11200291chr4:3514763ENST00000558013+118195_23322859.0DomainLDL-receptor class A 5
HgeneLDLRchr19:11200291chr4:3514763ENST00000558013+118234_27222859.0DomainLDL-receptor class A 6
HgeneLDLRchr19:11200291chr4:3514763ENST00000558013+11825_6522859.0DomainLDL-receptor class A 1
HgeneLDLRchr19:11200291chr4:3514763ENST00000558013+118274_31322859.0DomainLDL-receptor class A 7
HgeneLDLRchr19:11200291chr4:3514763ENST00000558013+118314_35322859.0DomainEGF-like 1
HgeneLDLRchr19:11200291chr4:3514763ENST00000558013+118354_39322859.0DomainEGF-like 2%3B calcium-binding
HgeneLDLRchr19:11200291chr4:3514763ENST00000558013+118663_71222859.0DomainEGF-like 3
HgeneLDLRchr19:11200291chr4:3514763ENST00000558013+11866_10622859.0DomainLDL-receptor class A 2
HgeneLDLRchr19:11200291chr4:3514763ENST00000558518+118107_14522861.0DomainLDL-receptor class A 3
HgeneLDLRchr19:11200291chr4:3514763ENST00000558518+118146_18622861.0DomainLDL-receptor class A 4
HgeneLDLRchr19:11200291chr4:3514763ENST00000558518+118195_23322861.0DomainLDL-receptor class A 5
HgeneLDLRchr19:11200291chr4:3514763ENST00000558518+118234_27222861.0DomainLDL-receptor class A 6
HgeneLDLRchr19:11200291chr4:3514763ENST00000558518+11825_6522861.0DomainLDL-receptor class A 1
HgeneLDLRchr19:11200291chr4:3514763ENST00000558518+118274_31322861.0DomainLDL-receptor class A 7
HgeneLDLRchr19:11200291chr4:3514763ENST00000558518+118314_35322861.0DomainEGF-like 1
HgeneLDLRchr19:11200291chr4:3514763ENST00000558518+118354_39322861.0DomainEGF-like 2%3B calcium-binding
HgeneLDLRchr19:11200291chr4:3514763ENST00000558518+118663_71222861.0DomainEGF-like 3
HgeneLDLRchr19:11200291chr4:3514763ENST00000558518+11866_10622861.0DomainLDL-receptor class A 2
HgeneLDLRchr19:11200291chr4:3514763ENST00000455727+116823_82822693.0MotifNPXY motif
HgeneLDLRchr19:11200291chr4:3514763ENST00000535915+117823_82822820.0MotifNPXY motif
HgeneLDLRchr19:11200291chr4:3514763ENST00000545707+116823_82822683.0MotifNPXY motif
HgeneLDLRchr19:11200291chr4:3514763ENST00000558013+118823_82822859.0MotifNPXY motif
HgeneLDLRchr19:11200291chr4:3514763ENST00000558518+118823_82822861.0MotifNPXY motif
HgeneLDLRchr19:11200291chr4:3514763ENST00000455727+116721_76822693.0RegionNote=Clustered O-linked oligosaccharides
HgeneLDLRchr19:11200291chr4:3514763ENST00000455727+116811_86022693.0RegionRequired for MYLIP-triggered down-regulation of LDLR
HgeneLDLRchr19:11200291chr4:3514763ENST00000535915+117721_76822820.0RegionNote=Clustered O-linked oligosaccharides
HgeneLDLRchr19:11200291chr4:3514763ENST00000535915+117811_86022820.0RegionRequired for MYLIP-triggered down-regulation of LDLR
HgeneLDLRchr19:11200291chr4:3514763ENST00000545707+116721_76822683.0RegionNote=Clustered O-linked oligosaccharides
HgeneLDLRchr19:11200291chr4:3514763ENST00000545707+116811_86022683.0RegionRequired for MYLIP-triggered down-regulation of LDLR
HgeneLDLRchr19:11200291chr4:3514763ENST00000558013+118721_76822859.0RegionNote=Clustered O-linked oligosaccharides
HgeneLDLRchr19:11200291chr4:3514763ENST00000558013+118811_86022859.0RegionRequired for MYLIP-triggered down-regulation of LDLR
HgeneLDLRchr19:11200291chr4:3514763ENST00000558518+118721_76822861.0RegionNote=Clustered O-linked oligosaccharides
HgeneLDLRchr19:11200291chr4:3514763ENST00000558518+118811_86022861.0RegionRequired for MYLIP-triggered down-regulation of LDLR
HgeneLDLRchr19:11200291chr4:3514763ENST00000455727+116397_43822693.0RepeatNote=LDL-receptor class B 1
HgeneLDLRchr19:11200291chr4:3514763ENST00000455727+116439_48522693.0RepeatNote=LDL-receptor class B 2
HgeneLDLRchr19:11200291chr4:3514763ENST00000455727+116486_52822693.0RepeatNote=LDL-receptor class B 3
HgeneLDLRchr19:11200291chr4:3514763ENST00000455727+116529_57222693.0RepeatNote=LDL-receptor class B 4
HgeneLDLRchr19:11200291chr4:3514763ENST00000455727+116573_61522693.0RepeatNote=LDL-receptor class B 5
HgeneLDLRchr19:11200291chr4:3514763ENST00000455727+116616_65822693.0RepeatNote=LDL-receptor class B 6
HgeneLDLRchr19:11200291chr4:3514763ENST00000535915+117397_43822820.0RepeatNote=LDL-receptor class B 1
HgeneLDLRchr19:11200291chr4:3514763ENST00000535915+117439_48522820.0RepeatNote=LDL-receptor class B 2
HgeneLDLRchr19:11200291chr4:3514763ENST00000535915+117486_52822820.0RepeatNote=LDL-receptor class B 3
HgeneLDLRchr19:11200291chr4:3514763ENST00000535915+117529_57222820.0RepeatNote=LDL-receptor class B 4
HgeneLDLRchr19:11200291chr4:3514763ENST00000535915+117573_61522820.0RepeatNote=LDL-receptor class B 5
HgeneLDLRchr19:11200291chr4:3514763ENST00000535915+117616_65822820.0RepeatNote=LDL-receptor class B 6
HgeneLDLRchr19:11200291chr4:3514763ENST00000545707+116397_43822683.0RepeatNote=LDL-receptor class B 1
HgeneLDLRchr19:11200291chr4:3514763ENST00000545707+116439_48522683.0RepeatNote=LDL-receptor class B 2
HgeneLDLRchr19:11200291chr4:3514763ENST00000545707+116486_52822683.0RepeatNote=LDL-receptor class B 3
HgeneLDLRchr19:11200291chr4:3514763ENST00000545707+116529_57222683.0RepeatNote=LDL-receptor class B 4
HgeneLDLRchr19:11200291chr4:3514763ENST00000545707+116573_61522683.0RepeatNote=LDL-receptor class B 5
HgeneLDLRchr19:11200291chr4:3514763ENST00000545707+116616_65822683.0RepeatNote=LDL-receptor class B 6
HgeneLDLRchr19:11200291chr4:3514763ENST00000558013+118397_43822859.0RepeatNote=LDL-receptor class B 1
HgeneLDLRchr19:11200291chr4:3514763ENST00000558013+118439_48522859.0RepeatNote=LDL-receptor class B 2
HgeneLDLRchr19:11200291chr4:3514763ENST00000558013+118486_52822859.0RepeatNote=LDL-receptor class B 3
HgeneLDLRchr19:11200291chr4:3514763ENST00000558013+118529_57222859.0RepeatNote=LDL-receptor class B 4
HgeneLDLRchr19:11200291chr4:3514763ENST00000558013+118573_61522859.0RepeatNote=LDL-receptor class B 5
HgeneLDLRchr19:11200291chr4:3514763ENST00000558013+118616_65822859.0RepeatNote=LDL-receptor class B 6
HgeneLDLRchr19:11200291chr4:3514763ENST00000558518+118397_43822861.0RepeatNote=LDL-receptor class B 1
HgeneLDLRchr19:11200291chr4:3514763ENST00000558518+118439_48522861.0RepeatNote=LDL-receptor class B 2
HgeneLDLRchr19:11200291chr4:3514763ENST00000558518+118486_52822861.0RepeatNote=LDL-receptor class B 3
HgeneLDLRchr19:11200291chr4:3514763ENST00000558518+118529_57222861.0RepeatNote=LDL-receptor class B 4
HgeneLDLRchr19:11200291chr4:3514763ENST00000558518+118573_61522861.0RepeatNote=LDL-receptor class B 5
HgeneLDLRchr19:11200291chr4:3514763ENST00000558518+118616_65822861.0RepeatNote=LDL-receptor class B 6
HgeneLDLRchr19:11200291chr4:3514763ENST00000455727+11622_78822693.0Topological domainExtracellular
HgeneLDLRchr19:11200291chr4:3514763ENST00000535915+11722_78822820.0Topological domainExtracellular
HgeneLDLRchr19:11200291chr4:3514763ENST00000545707+11622_78822683.0Topological domainExtracellular
HgeneLDLRchr19:11200291chr4:3514763ENST00000558013+11822_78822859.0Topological domainExtracellular
HgeneLDLRchr19:11200291chr4:3514763ENST00000558518+11822_78822861.0Topological domainExtracellular
HgeneLDLRchr19:11200291chr4:3514763ENST00000455727+116789_81022693.0TransmembraneHelical
HgeneLDLRchr19:11200291chr4:3514763ENST00000535915+117789_81022820.0TransmembraneHelical
HgeneLDLRchr19:11200291chr4:3514763ENST00000545707+116789_81022683.0TransmembraneHelical
HgeneLDLRchr19:11200291chr4:3514763ENST00000558013+118789_81022859.0TransmembraneHelical
HgeneLDLRchr19:11200291chr4:3514763ENST00000558518+118789_81022861.0TransmembraneHelical
TgeneLRPAP1chr19:11200291chr4:3514763ENST0000050072868219_310337358.0Coiled coilOntology_term=ECO:0000255
TgeneLRPAP1chr19:11200291chr4:3514763ENST0000050072868237_353337358.0RegionLDL receptor binding


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Fusion Gene Sequence for LDLR-LRPAP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>44413_44413_1_LDLR-LRPAP1_LDLR_chr19_11200291_ENST00000455727_LRPAP1_chr4_3514763_ENST00000500728_length(transcript)=6814nt_BP=153nt
GTGCAATCGCGGGAAGCCAGGGTTTCCAGCTAGGACACAGCAGGTCGTGATCCGGGTCGGGACACTGCCTGGCAGAGGCTGCGAGCATGG
GGCCCTGGGGCTGGAAATTGCGCTGGACCGTCGCCTTGCTCCTCGCCGCGGCGGGGACTGCAGGTGAAGAAGCATCTGCAGGACCTGTCC
GGCAGGATCTCCAGAGCTCGGCACAACGAACTCTGAAGGCATTGGGGAGCCCAGCCCGGCAGGGAAGAGGCCAGCGTGAAGGACCTGGGC
TCTTGGCCGTGGCATTTCCGTGGACAGCCCGCCGTCAGGGTGGCTGGGGCTGGCACGGGTGTCGAGGCAGGAAGGATTGTTTCTGGTGAC
TGCAGCCGCTGCCGTCGCGACACAGGGCTTGGTGGTGGTAGCATTTGGGTCTGAGATCGGCCCAGCTCTGACTGAAGGGGCTTGGCTTCC
ACTCAGCATCAGCGTGGCAGTCACCACCCCAGTGAGGACCTCGATGTCCAGCTGCTGTCAGGTCTGATAGTCCTCTGCTAAAACAACACG
ATTTACATAAAAAATCTTACACATCTGCCACCGGAAATACCATGCACAGAGTCCTTAAAAAATAGAGTGCAGTATTTAAACCACCCGCTT
GTTGGCTGGTCACTAAGTGTCCTGGTGGCTGGGGCCGGAGCCAGTGCTCTTGAAGGGATCGCGTCATAGCCAGCTTCCCCTCTGGGCCCT
GTGGGTCTTTGCAGCCAACCTCCTTTTCCCGTGAGACGGCCCGGCCTGATTTAAAGCCAAGAGCGCTTGAGTTGAGTTTGAGGGGAAGAT
GTGGAGCGTGTGGTTCTGTGGACAGTCAGAGACTGTGGCCTGGGGGCAGCGTCTTTCAACTCTCACCTCTGCAGCTCAGGGACCTCGGGA
GACCTCACCAAACCTGCAGGGCCTCCGTGTCCCTAAGTGTGCTGTGTAAATGCCCCATCTCATGGGGGAGAGACAGCCACGGAGGCCTTC
CTCTGACCATAGCTGATGGACTGGCGGTTGCTCAGGTCCGGCTCCGAGAATGTTCCTGTGTCTGAGCCTGGAAGAGGCTCGGGTCTGGCT
CCAGGCGTGGTTCCCTTCCCGTGTCTGAGCCTGGAAGAGGCTCGGGTCCGGCTCCGAGCGTGGTTCCCTTCCCGTGTCTGAGCCTGGAAG
AGGCTCGGGTCCGGCTCCGAGCGTGGTTCCCTTCCCGTGTCTGAGCCTGGAAGAGGCTCGGGTCCGGCTCCGAGCGTGGTTCCCTTCCCG
TGTCTGAGCCTGGAAGAGGCTCGGGTCCGGCTCCGAGCGTGGTTCCCTTCCCGTGTCTGAGCCTGGAAGAGGCTCGGGTCCGGCTCTGGG
CGTGGTTCCCTTCCCGTGTCTGAGCCTGGAAGAGGCTCGGGTCCGGCTCTGGGCGTGGTTCCCGTGTCTGAGCCTGGAAGAGGCTCGGGT
CCGGGTCCAGCTCCGAGCGTGGTTCCCGTGTTTGAACCTGGAAGAGGCTCCACCAGGCGTATTGTGTTTTGACTGCAGCTGGATCTTGGC
TTGACTGTTGAGATCTGCCAAACATCCGCTAAGCTATCATTTCTGAGAAAGGTCAAGGCTAGAGGCAGCATGTCGGGAGTTGGCGCATCA
GGGTTGGAAGGGCCCCAGGGTACAGCATGTGGGTGCCTGTTCCTTTGTGGACTTGTGTGTGTGTGGCTGGTGGGGCGGGGGGTGGATTCT
GGTTCTTTTTTTTCCCATTATCCTGAGAGCCTTAAGGTACTCAGTGTGTTGGTGAGACTCAGCCCTGTCATCTAGCAGAAGTGTGTTCCT
TTTCATTGCTGTATAGTATTCCATTGCATGACTGTCCTGTGCTCTGATTTTAATGCACTTTATTGTGGGTGGATATTTGAGTTGCTTCCT
TTCTGGGGTAATAACACTCACTTGGAAATAGCTGTGGTGAACACTCGTGTGGGGGTGGGGGTGGGGGCCAACTCTAGGAGCACCTAATGG
ATCTTACGAAGCGTGTTGTCCAAGTATAGAGATGATTCCAAAGTGGTTGGACTGTGTTTCTTTCTCCCAGCTGGGTGGAAGGAGAACACT
AGTGGATTGCTGAGACTTGGTGCTCGGTATTTTTAATTATGGACAGCCTGGCTGGCGTTTTGTGGTGTCTAATTGCGGAGTAGCGTGTCT
TACTGTATAATGGCCTCTTTTGTATGTGGGAGACCATGGTGTTGAGGGGAGGCAGTTACACAAAAAACCCAGATACCGAGTGTTAGTTCC
ATGGGTGTGGCTGGTCATGGTGCGCACTCACGAAGGATGTAGGTGATGCCCTCCACTCCGCAGAGCCAGTCCCACAGGGGTACCCATTCT
GACTCCTACCACCGCAGCTCCCTACCTCCCGCCTGCCATGGGTTCCACGTGCATGGCTCTGGGCAGTCTGTGTCTTTGCGTGCGTCTGTG
TATGTCTGCGTGTATCTGCTTACATTCGCTCAGCATCTGAGATTCACCCAGGCTTTTGCGTGGATCAGCGGCAGACTCCTGATTGCCGCG
TGGCGGCCTGTTGTGTGGGTGTGTGCCGCGTGTGTATCCAGTCCCTACTCAGGAGTGTACGTTTCCAGTGTGGGTTGCAGTCAGGATCCA
TTTCTCCCTTAACTTTCAGATTATTTGCTGCATAGGCTTTTTTCTCCTAATTTGGCGCCTTTGTCAGAAATCAACTGACCTACCTGTGTG
GGTCTGTTTCTGTTTGTCCTTACGCTCTTGCCATTGCCACACTTTAGACAAGGTCTTGCTCTGTCCCTCAGGCTGGAGTGCAGTAGCGTG
ATCTCAGCTCACTGCACCCTTGACCTCCCATACTCCAGCAATCCCCTCGCCTCAGTCTCCTGAGTAGTAGCTGCGACCACAGGCGTGTGT
CACCACACCCGGCTGATTTTATTTTTTTTATTTTTATTTTTTTTGTAGAGACGGGGTTTTACTATGTTGCCCAGGCAGGTCTTGATCTGG
GCTCAAGTGATGCTCCTGTCTCAGCCTCCCAAACTACTGGGATTACAGGTTGTAGGTGTGAGCCATGGTGCCCGGCCGCCACACTGTCTT
GGCTACAGTTGGGTTTATAATAAACCCTGAATCGAGGTGATGTGCATTTTCCAACTCTTCTTTTTAAAGATTCTTGTGGCTGTTTATGTC
CTTGGTGTTTCCATATATGTTTTACAATCAGTGTCTCAATTTCTACCAAAAAAACATGCCTTCTGGAATTTCAATAGCAATTCCCTTGAA
CGCATTTTTGAATACCTTTTCTGAATGTCTTGAATACATGTTGGGAAGAATCGGTGTCTTAACAGTCTCCAGTGTCCACGCGTTGACTGC
CGTGTGTGACTCCAGTCGGCGTCTCAACAGTCTCCAGTGTCCACGCGTTGACTGCCGTGTGTGACTCCAGTCGGCGTCTCAGCAGTCTCC
AGTGTCCACGCGTTGACTGCCGTGTGTGACTCCAGTCGGCGTCTCAGCAGTCTCCAGTGTCCACGCGTTGACTGCCGTGTGTGACTCCAG
TCGGCGTCTCAGCAGTCTCCGGTGTCCACGCGTTGACTGCCGTGTGTGACTCCAGTCGGCGTCTCAACAGTCTCCGGTGTCCACGCGTTG
ACTGCCGTGTGTGACTCCAGTCGGCGTCTCAACAGTCTCCGGTGTCCACGCGTTGACTGCCGTGTGTGACTCCAGTCGGCGTCTCAACAG
TCTCCGGTGTCCACGCGTTGACTGCCGTGTGTGACTCCAGTCGGCGTCTCAACAGTCTCCGGTGTCCACGCGTTGACTGCCGTGTGTGAC
TCCAGTCGGCGTCTCAACAGTCTCCGGTGTCCACGCGTTGACTGCCGTGTGTGACTCCAGTCGGCGTCTCAACAGTCTCCGGTGTCCACG
CGTTGACTGCCGTGTGTGACTCCAGTCGGCGTCTCAACAGTCTCCGGTGTCCACGCGTTGACTGCCGTGTGTGACTCCAGTCGGCGTCTC
AACAGTCTCCGGTGTCCATGCGTTGACTGCCATGTATGACTCCAGGTATTGAGTTCATCTTCAACTTCTCCCAACAATGAACTGGAGTTT
TCTGTGCATGTGTCTGGCATGTTTTCCTTTAGATCTAGTCCTAGGTGTTCGATATGCTATTGAGGACTGTGTATTTTTATTTCATTTGTC
ACCTGTGCGTGGTGCTTTAATCCTGTGCCCTAAACTCCCGCCTTGGCCATGGCGGTGTTTCTGTGGACTCGTGGGGTTTCCGTGTGCACA
CGCGTGTCCTCTGTCTGACAGTGGCTTTGCTTCCCCTTGTCAGTCTGTGCCTCGGCTTCTCACTGCACTGGTGAGGTGAGCCGGCGCTCG
CTAATCTTATTCCCAGTCTCGGTGAACATGGGCTCAGTCTCTCCCGGCTCAGTGTTGGGTTTGCACTGGTGCACTTACAGGCAGAAGAGC
TTCCTCATTTGCTGAGGGCTTTTCCTGAATCCGTGTTGAATGTGGTCAGCTGCCTTTCCTGCACCTAGTGAGATGCTCATGAGGTCACTT
CCTTACCGCATTACTGTAGTGAATTACGCTGACTTTCATATGCCAAGATGACCTGGCATTTCCAGGTAAGTCCCTGTGGCCATGGTGCAT
TGGCCTTTTCTCTGCATGGCCAGATGAGATTTGCTCATACCGGGCTAAGGACCTCCTGTGTAGGAATGCTCTTGAGGGACACTGGGCTTG
GATGTTCATTGTCTTGTCATGTGATGTGTCTGTCATGGTTTGATATTGCATTAAGTGGGCCTCCTGAAACAAGTTCTGCCATAGTTTGTA
TAGGATTGGCATTATTTGTTTCATAGAGATGTGATGGGTGAGGCCATCTATGCCTGCCATTTTCTTTTTGCTTAGGTTTTTCATTAAGAA
CTTGATTTTTAAAAATAGACATGAGGCCTGGCATGGTGGCTCACGCTTGTAATCCCAGCACTTTGGGAGGCCAACGTGGATGGATCACCT
GAGGTCAGGAGTTTGAGACCAACCTAGTCAACATGGTGAAACCCCGTCTCCATTAAAAATATAAAAATTAGCAGGGTGTGGTGGTGCATG
CCTGTAATCCCAGCTACTCTGGAGGCTGAGGCAGGAGAATCACTTGAACTCAGGAGGTGGAGGTTGCAGTGAGCTGAGATCACACCACTG
CACTCCAGCCTGGGCAACAGAGCGAGGCTCTGTCTCAAAAAAAAAGACATGAGGCTTTTGGATTTTCTGTTTCTTCCTTTGTCATTTTTT
TAAAGATAGGTTTGTCGCAGAATTTCATCTAAGTTATCAAAACAATTTACATAAATCATTCACAGTATCCTCTGTGCAGTGATGTCCATT
CTCATTCCTGCTCTGGGCCATTTGTGTTTTCTTTTCCCCCTGATCAGACTAGCTAAGAGTTTATCATTTTTACAGATATTTTCCCCAAAG
AAACCTACTTTTGGGTCCATTGATTTTTTTTTTCTATTGTTTTCTTTTTCATTGACTTTTGCTCTTTTCTTATGAATTTCCTTTCTTCTA
CCTATTTTGTGTTCAATTTGCTGTCCTTGTTTTAGGTTCTTTTGATAGAGGCTTAGATCATTGATGAAGAATATGAAAGAATGGGATAAT
ACAGTTAAAAACTTGGTCTACTTATGCCCATTAGAGAAAACATTCTTAAGCACGCATGGAATCTTTTAAAAATGGACGAGGTACTAGGAC
CCAAAGCAAATGTCAGTAATTCGCAGATGATAATGTATAAATATATGATATGTAGGTAAATAATACAAATCACATTCTTTGGCCAGAGTG
CAATTGAGGAGGAAATCAGTAACAAAAAGACAATTAAATCCATTTGATTCTTTTGTTTTCGTTTTGTAGTAACTTGCACTTCCCTGGTGC
CAGAGGCATGACACCTTTTTGTCTGCTCTTGGCCATTTGGGTGGCGTCTTTGGGAAGGGCCTACTTAATTCTTTTGCCTATTTAAAAAAC
TGGGTCTTGGAAATCTTGTCTTTTTTTTTGAGTCAGGATCTTTCTCGCACAGGCTTGGAGTGCAGTGGTGCGATCATAGCTCACTGCAAC
CTCAAACTCCTGGGCTCAAGCGAGCCTCCCACCTCGGTCTTCTGAGTAGCTGGGACTACAGGCATGCATCACTATGCTCTGCTAATTTAA
AGAAAAGGTTTTTTTTATAGAGACTGGGTCTCGCTGTGTTGCCCAGGCTGGTCTCGGAGTCCTGGTCTCAAGTGATTCACCTGCCTCCAC
CTCGCGGAGTGCCAGGATTACAGGTGGCGGGAGCCGCCACACCCAGCCTGGTCTTAGCGTTATTCCCAGGTCTAGGTGTGAGTCCTTCCT
CAGATATGTGTTGTGAATAATTTCCGATCCTCTGGCTTGCTATTTTACTTTCTTAATGGTTATCTTTTGGAAAGCAAAGGTTTCCAGTTT
GATGAAATCTAATTTTTATTTTTTATTTTTCCGTTCTAGTGGTCTTTCTATTTTCTCATCAAATTGAGACTTTGGGGAAACTACACAGCA
GCAAACCAGGATATATCCTCTTAAAAACAGCTCGAGCCGGCCGGGTGCGGTGGCTCATGCCTGGAATCCCAGCACTTTGGGAGGTGGAGG
TGGGCGGATCACGTGAGGTCAGGAGTTTGAGACCAGCCTGGCCAACATGGTGAAACCCCATCTCTACTAAAAATAAAAAATTAGCCAGGC
ATGGTGGCAGGCACCTGTAATCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATGGCTTGAACCTGGGAGGCAGAGGTTGCAGTGAGCCGA

>44413_44413_1_LDLR-LRPAP1_LDLR_chr19_11200291_ENST00000455727_LRPAP1_chr4_3514763_ENST00000500728_length(amino acids)=221AA_BP=36
MADLNSQAKIQLQSKHNTPGGASSRFKHGNHARSWTRTRASSRLRHGNHAQSRTRASSRLRHGKGTTPRAGPEPLPGSDTGREPRSEPDP
SLFQAQTREGNHARSRTRASSRLRHGKGTTLGAGPEPLPGSDTGREPRSEPDPSLFQAQTREGNHAWSQTRASSRLRHRNILGAGPEQPP

--------------------------------------------------------------
>44413_44413_2_LDLR-LRPAP1_LDLR_chr19_11200291_ENST00000535915_LRPAP1_chr4_3514763_ENST00000500728_length(transcript)=6814nt_BP=153nt
GTGCAATCGCGGGAAGCCAGGGTTTCCAGCTAGGACACAGCAGGTCGTGATCCGGGTCGGGACACTGCCTGGCAGAGGCTGCGAGCATGG
GGCCCTGGGGCTGGAAATTGCGCTGGACCGTCGCCTTGCTCCTCGCCGCGGCGGGGACTGCAGGTGAAGAAGCATCTGCAGGACCTGTCC
GGCAGGATCTCCAGAGCTCGGCACAACGAACTCTGAAGGCATTGGGGAGCCCAGCCCGGCAGGGAAGAGGCCAGCGTGAAGGACCTGGGC
TCTTGGCCGTGGCATTTCCGTGGACAGCCCGCCGTCAGGGTGGCTGGGGCTGGCACGGGTGTCGAGGCAGGAAGGATTGTTTCTGGTGAC
TGCAGCCGCTGCCGTCGCGACACAGGGCTTGGTGGTGGTAGCATTTGGGTCTGAGATCGGCCCAGCTCTGACTGAAGGGGCTTGGCTTCC
ACTCAGCATCAGCGTGGCAGTCACCACCCCAGTGAGGACCTCGATGTCCAGCTGCTGTCAGGTCTGATAGTCCTCTGCTAAAACAACACG
ATTTACATAAAAAATCTTACACATCTGCCACCGGAAATACCATGCACAGAGTCCTTAAAAAATAGAGTGCAGTATTTAAACCACCCGCTT
GTTGGCTGGTCACTAAGTGTCCTGGTGGCTGGGGCCGGAGCCAGTGCTCTTGAAGGGATCGCGTCATAGCCAGCTTCCCCTCTGGGCCCT
GTGGGTCTTTGCAGCCAACCTCCTTTTCCCGTGAGACGGCCCGGCCTGATTTAAAGCCAAGAGCGCTTGAGTTGAGTTTGAGGGGAAGAT
GTGGAGCGTGTGGTTCTGTGGACAGTCAGAGACTGTGGCCTGGGGGCAGCGTCTTTCAACTCTCACCTCTGCAGCTCAGGGACCTCGGGA
GACCTCACCAAACCTGCAGGGCCTCCGTGTCCCTAAGTGTGCTGTGTAAATGCCCCATCTCATGGGGGAGAGACAGCCACGGAGGCCTTC
CTCTGACCATAGCTGATGGACTGGCGGTTGCTCAGGTCCGGCTCCGAGAATGTTCCTGTGTCTGAGCCTGGAAGAGGCTCGGGTCTGGCT
CCAGGCGTGGTTCCCTTCCCGTGTCTGAGCCTGGAAGAGGCTCGGGTCCGGCTCCGAGCGTGGTTCCCTTCCCGTGTCTGAGCCTGGAAG
AGGCTCGGGTCCGGCTCCGAGCGTGGTTCCCTTCCCGTGTCTGAGCCTGGAAGAGGCTCGGGTCCGGCTCCGAGCGTGGTTCCCTTCCCG
TGTCTGAGCCTGGAAGAGGCTCGGGTCCGGCTCCGAGCGTGGTTCCCTTCCCGTGTCTGAGCCTGGAAGAGGCTCGGGTCCGGCTCTGGG
CGTGGTTCCCTTCCCGTGTCTGAGCCTGGAAGAGGCTCGGGTCCGGCTCTGGGCGTGGTTCCCGTGTCTGAGCCTGGAAGAGGCTCGGGT
CCGGGTCCAGCTCCGAGCGTGGTTCCCGTGTTTGAACCTGGAAGAGGCTCCACCAGGCGTATTGTGTTTTGACTGCAGCTGGATCTTGGC
TTGACTGTTGAGATCTGCCAAACATCCGCTAAGCTATCATTTCTGAGAAAGGTCAAGGCTAGAGGCAGCATGTCGGGAGTTGGCGCATCA
GGGTTGGAAGGGCCCCAGGGTACAGCATGTGGGTGCCTGTTCCTTTGTGGACTTGTGTGTGTGTGGCTGGTGGGGCGGGGGGTGGATTCT
GGTTCTTTTTTTTCCCATTATCCTGAGAGCCTTAAGGTACTCAGTGTGTTGGTGAGACTCAGCCCTGTCATCTAGCAGAAGTGTGTTCCT
TTTCATTGCTGTATAGTATTCCATTGCATGACTGTCCTGTGCTCTGATTTTAATGCACTTTATTGTGGGTGGATATTTGAGTTGCTTCCT
TTCTGGGGTAATAACACTCACTTGGAAATAGCTGTGGTGAACACTCGTGTGGGGGTGGGGGTGGGGGCCAACTCTAGGAGCACCTAATGG
ATCTTACGAAGCGTGTTGTCCAAGTATAGAGATGATTCCAAAGTGGTTGGACTGTGTTTCTTTCTCCCAGCTGGGTGGAAGGAGAACACT
AGTGGATTGCTGAGACTTGGTGCTCGGTATTTTTAATTATGGACAGCCTGGCTGGCGTTTTGTGGTGTCTAATTGCGGAGTAGCGTGTCT
TACTGTATAATGGCCTCTTTTGTATGTGGGAGACCATGGTGTTGAGGGGAGGCAGTTACACAAAAAACCCAGATACCGAGTGTTAGTTCC
ATGGGTGTGGCTGGTCATGGTGCGCACTCACGAAGGATGTAGGTGATGCCCTCCACTCCGCAGAGCCAGTCCCACAGGGGTACCCATTCT
GACTCCTACCACCGCAGCTCCCTACCTCCCGCCTGCCATGGGTTCCACGTGCATGGCTCTGGGCAGTCTGTGTCTTTGCGTGCGTCTGTG
TATGTCTGCGTGTATCTGCTTACATTCGCTCAGCATCTGAGATTCACCCAGGCTTTTGCGTGGATCAGCGGCAGACTCCTGATTGCCGCG
TGGCGGCCTGTTGTGTGGGTGTGTGCCGCGTGTGTATCCAGTCCCTACTCAGGAGTGTACGTTTCCAGTGTGGGTTGCAGTCAGGATCCA
TTTCTCCCTTAACTTTCAGATTATTTGCTGCATAGGCTTTTTTCTCCTAATTTGGCGCCTTTGTCAGAAATCAACTGACCTACCTGTGTG
GGTCTGTTTCTGTTTGTCCTTACGCTCTTGCCATTGCCACACTTTAGACAAGGTCTTGCTCTGTCCCTCAGGCTGGAGTGCAGTAGCGTG
ATCTCAGCTCACTGCACCCTTGACCTCCCATACTCCAGCAATCCCCTCGCCTCAGTCTCCTGAGTAGTAGCTGCGACCACAGGCGTGTGT
CACCACACCCGGCTGATTTTATTTTTTTTATTTTTATTTTTTTTGTAGAGACGGGGTTTTACTATGTTGCCCAGGCAGGTCTTGATCTGG
GCTCAAGTGATGCTCCTGTCTCAGCCTCCCAAACTACTGGGATTACAGGTTGTAGGTGTGAGCCATGGTGCCCGGCCGCCACACTGTCTT
GGCTACAGTTGGGTTTATAATAAACCCTGAATCGAGGTGATGTGCATTTTCCAACTCTTCTTTTTAAAGATTCTTGTGGCTGTTTATGTC
CTTGGTGTTTCCATATATGTTTTACAATCAGTGTCTCAATTTCTACCAAAAAAACATGCCTTCTGGAATTTCAATAGCAATTCCCTTGAA
CGCATTTTTGAATACCTTTTCTGAATGTCTTGAATACATGTTGGGAAGAATCGGTGTCTTAACAGTCTCCAGTGTCCACGCGTTGACTGC
CGTGTGTGACTCCAGTCGGCGTCTCAACAGTCTCCAGTGTCCACGCGTTGACTGCCGTGTGTGACTCCAGTCGGCGTCTCAGCAGTCTCC
AGTGTCCACGCGTTGACTGCCGTGTGTGACTCCAGTCGGCGTCTCAGCAGTCTCCAGTGTCCACGCGTTGACTGCCGTGTGTGACTCCAG
TCGGCGTCTCAGCAGTCTCCGGTGTCCACGCGTTGACTGCCGTGTGTGACTCCAGTCGGCGTCTCAACAGTCTCCGGTGTCCACGCGTTG
ACTGCCGTGTGTGACTCCAGTCGGCGTCTCAACAGTCTCCGGTGTCCACGCGTTGACTGCCGTGTGTGACTCCAGTCGGCGTCTCAACAG
TCTCCGGTGTCCACGCGTTGACTGCCGTGTGTGACTCCAGTCGGCGTCTCAACAGTCTCCGGTGTCCACGCGTTGACTGCCGTGTGTGAC
TCCAGTCGGCGTCTCAACAGTCTCCGGTGTCCACGCGTTGACTGCCGTGTGTGACTCCAGTCGGCGTCTCAACAGTCTCCGGTGTCCACG
CGTTGACTGCCGTGTGTGACTCCAGTCGGCGTCTCAACAGTCTCCGGTGTCCACGCGTTGACTGCCGTGTGTGACTCCAGTCGGCGTCTC
AACAGTCTCCGGTGTCCATGCGTTGACTGCCATGTATGACTCCAGGTATTGAGTTCATCTTCAACTTCTCCCAACAATGAACTGGAGTTT
TCTGTGCATGTGTCTGGCATGTTTTCCTTTAGATCTAGTCCTAGGTGTTCGATATGCTATTGAGGACTGTGTATTTTTATTTCATTTGTC
ACCTGTGCGTGGTGCTTTAATCCTGTGCCCTAAACTCCCGCCTTGGCCATGGCGGTGTTTCTGTGGACTCGTGGGGTTTCCGTGTGCACA
CGCGTGTCCTCTGTCTGACAGTGGCTTTGCTTCCCCTTGTCAGTCTGTGCCTCGGCTTCTCACTGCACTGGTGAGGTGAGCCGGCGCTCG
CTAATCTTATTCCCAGTCTCGGTGAACATGGGCTCAGTCTCTCCCGGCTCAGTGTTGGGTTTGCACTGGTGCACTTACAGGCAGAAGAGC
TTCCTCATTTGCTGAGGGCTTTTCCTGAATCCGTGTTGAATGTGGTCAGCTGCCTTTCCTGCACCTAGTGAGATGCTCATGAGGTCACTT
CCTTACCGCATTACTGTAGTGAATTACGCTGACTTTCATATGCCAAGATGACCTGGCATTTCCAGGTAAGTCCCTGTGGCCATGGTGCAT
TGGCCTTTTCTCTGCATGGCCAGATGAGATTTGCTCATACCGGGCTAAGGACCTCCTGTGTAGGAATGCTCTTGAGGGACACTGGGCTTG
GATGTTCATTGTCTTGTCATGTGATGTGTCTGTCATGGTTTGATATTGCATTAAGTGGGCCTCCTGAAACAAGTTCTGCCATAGTTTGTA
TAGGATTGGCATTATTTGTTTCATAGAGATGTGATGGGTGAGGCCATCTATGCCTGCCATTTTCTTTTTGCTTAGGTTTTTCATTAAGAA
CTTGATTTTTAAAAATAGACATGAGGCCTGGCATGGTGGCTCACGCTTGTAATCCCAGCACTTTGGGAGGCCAACGTGGATGGATCACCT
GAGGTCAGGAGTTTGAGACCAACCTAGTCAACATGGTGAAACCCCGTCTCCATTAAAAATATAAAAATTAGCAGGGTGTGGTGGTGCATG
CCTGTAATCCCAGCTACTCTGGAGGCTGAGGCAGGAGAATCACTTGAACTCAGGAGGTGGAGGTTGCAGTGAGCTGAGATCACACCACTG
CACTCCAGCCTGGGCAACAGAGCGAGGCTCTGTCTCAAAAAAAAAGACATGAGGCTTTTGGATTTTCTGTTTCTTCCTTTGTCATTTTTT
TAAAGATAGGTTTGTCGCAGAATTTCATCTAAGTTATCAAAACAATTTACATAAATCATTCACAGTATCCTCTGTGCAGTGATGTCCATT
CTCATTCCTGCTCTGGGCCATTTGTGTTTTCTTTTCCCCCTGATCAGACTAGCTAAGAGTTTATCATTTTTACAGATATTTTCCCCAAAG
AAACCTACTTTTGGGTCCATTGATTTTTTTTTTCTATTGTTTTCTTTTTCATTGACTTTTGCTCTTTTCTTATGAATTTCCTTTCTTCTA
CCTATTTTGTGTTCAATTTGCTGTCCTTGTTTTAGGTTCTTTTGATAGAGGCTTAGATCATTGATGAAGAATATGAAAGAATGGGATAAT
ACAGTTAAAAACTTGGTCTACTTATGCCCATTAGAGAAAACATTCTTAAGCACGCATGGAATCTTTTAAAAATGGACGAGGTACTAGGAC
CCAAAGCAAATGTCAGTAATTCGCAGATGATAATGTATAAATATATGATATGTAGGTAAATAATACAAATCACATTCTTTGGCCAGAGTG
CAATTGAGGAGGAAATCAGTAACAAAAAGACAATTAAATCCATTTGATTCTTTTGTTTTCGTTTTGTAGTAACTTGCACTTCCCTGGTGC
CAGAGGCATGACACCTTTTTGTCTGCTCTTGGCCATTTGGGTGGCGTCTTTGGGAAGGGCCTACTTAATTCTTTTGCCTATTTAAAAAAC
TGGGTCTTGGAAATCTTGTCTTTTTTTTTGAGTCAGGATCTTTCTCGCACAGGCTTGGAGTGCAGTGGTGCGATCATAGCTCACTGCAAC
CTCAAACTCCTGGGCTCAAGCGAGCCTCCCACCTCGGTCTTCTGAGTAGCTGGGACTACAGGCATGCATCACTATGCTCTGCTAATTTAA
AGAAAAGGTTTTTTTTATAGAGACTGGGTCTCGCTGTGTTGCCCAGGCTGGTCTCGGAGTCCTGGTCTCAAGTGATTCACCTGCCTCCAC
CTCGCGGAGTGCCAGGATTACAGGTGGCGGGAGCCGCCACACCCAGCCTGGTCTTAGCGTTATTCCCAGGTCTAGGTGTGAGTCCTTCCT
CAGATATGTGTTGTGAATAATTTCCGATCCTCTGGCTTGCTATTTTACTTTCTTAATGGTTATCTTTTGGAAAGCAAAGGTTTCCAGTTT
GATGAAATCTAATTTTTATTTTTTATTTTTCCGTTCTAGTGGTCTTTCTATTTTCTCATCAAATTGAGACTTTGGGGAAACTACACAGCA
GCAAACCAGGATATATCCTCTTAAAAACAGCTCGAGCCGGCCGGGTGCGGTGGCTCATGCCTGGAATCCCAGCACTTTGGGAGGTGGAGG
TGGGCGGATCACGTGAGGTCAGGAGTTTGAGACCAGCCTGGCCAACATGGTGAAACCCCATCTCTACTAAAAATAAAAAATTAGCCAGGC
ATGGTGGCAGGCACCTGTAATCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATGGCTTGAACCTGGGAGGCAGAGGTTGCAGTGAGCCGA

>44413_44413_2_LDLR-LRPAP1_LDLR_chr19_11200291_ENST00000535915_LRPAP1_chr4_3514763_ENST00000500728_length(amino acids)=221AA_BP=36
MADLNSQAKIQLQSKHNTPGGASSRFKHGNHARSWTRTRASSRLRHGNHAQSRTRASSRLRHGKGTTPRAGPEPLPGSDTGREPRSEPDP
SLFQAQTREGNHARSRTRASSRLRHGKGTTLGAGPEPLPGSDTGREPRSEPDPSLFQAQTREGNHAWSQTRASSRLRHRNILGAGPEQPP

--------------------------------------------------------------
>44413_44413_3_LDLR-LRPAP1_LDLR_chr19_11200291_ENST00000545707_LRPAP1_chr4_3514763_ENST00000500728_length(transcript)=6814nt_BP=153nt
GTGCAATCGCGGGAAGCCAGGGTTTCCAGCTAGGACACAGCAGGTCGTGATCCGGGTCGGGACACTGCCTGGCAGAGGCTGCGAGCATGG
GGCCCTGGGGCTGGAAATTGCGCTGGACCGTCGCCTTGCTCCTCGCCGCGGCGGGGACTGCAGGTGAAGAAGCATCTGCAGGACCTGTCC
GGCAGGATCTCCAGAGCTCGGCACAACGAACTCTGAAGGCATTGGGGAGCCCAGCCCGGCAGGGAAGAGGCCAGCGTGAAGGACCTGGGC
TCTTGGCCGTGGCATTTCCGTGGACAGCCCGCCGTCAGGGTGGCTGGGGCTGGCACGGGTGTCGAGGCAGGAAGGATTGTTTCTGGTGAC
TGCAGCCGCTGCCGTCGCGACACAGGGCTTGGTGGTGGTAGCATTTGGGTCTGAGATCGGCCCAGCTCTGACTGAAGGGGCTTGGCTTCC
ACTCAGCATCAGCGTGGCAGTCACCACCCCAGTGAGGACCTCGATGTCCAGCTGCTGTCAGGTCTGATAGTCCTCTGCTAAAACAACACG
ATTTACATAAAAAATCTTACACATCTGCCACCGGAAATACCATGCACAGAGTCCTTAAAAAATAGAGTGCAGTATTTAAACCACCCGCTT
GTTGGCTGGTCACTAAGTGTCCTGGTGGCTGGGGCCGGAGCCAGTGCTCTTGAAGGGATCGCGTCATAGCCAGCTTCCCCTCTGGGCCCT
GTGGGTCTTTGCAGCCAACCTCCTTTTCCCGTGAGACGGCCCGGCCTGATTTAAAGCCAAGAGCGCTTGAGTTGAGTTTGAGGGGAAGAT
GTGGAGCGTGTGGTTCTGTGGACAGTCAGAGACTGTGGCCTGGGGGCAGCGTCTTTCAACTCTCACCTCTGCAGCTCAGGGACCTCGGGA
GACCTCACCAAACCTGCAGGGCCTCCGTGTCCCTAAGTGTGCTGTGTAAATGCCCCATCTCATGGGGGAGAGACAGCCACGGAGGCCTTC
CTCTGACCATAGCTGATGGACTGGCGGTTGCTCAGGTCCGGCTCCGAGAATGTTCCTGTGTCTGAGCCTGGAAGAGGCTCGGGTCTGGCT
CCAGGCGTGGTTCCCTTCCCGTGTCTGAGCCTGGAAGAGGCTCGGGTCCGGCTCCGAGCGTGGTTCCCTTCCCGTGTCTGAGCCTGGAAG
AGGCTCGGGTCCGGCTCCGAGCGTGGTTCCCTTCCCGTGTCTGAGCCTGGAAGAGGCTCGGGTCCGGCTCCGAGCGTGGTTCCCTTCCCG
TGTCTGAGCCTGGAAGAGGCTCGGGTCCGGCTCCGAGCGTGGTTCCCTTCCCGTGTCTGAGCCTGGAAGAGGCTCGGGTCCGGCTCTGGG
CGTGGTTCCCTTCCCGTGTCTGAGCCTGGAAGAGGCTCGGGTCCGGCTCTGGGCGTGGTTCCCGTGTCTGAGCCTGGAAGAGGCTCGGGT
CCGGGTCCAGCTCCGAGCGTGGTTCCCGTGTTTGAACCTGGAAGAGGCTCCACCAGGCGTATTGTGTTTTGACTGCAGCTGGATCTTGGC
TTGACTGTTGAGATCTGCCAAACATCCGCTAAGCTATCATTTCTGAGAAAGGTCAAGGCTAGAGGCAGCATGTCGGGAGTTGGCGCATCA
GGGTTGGAAGGGCCCCAGGGTACAGCATGTGGGTGCCTGTTCCTTTGTGGACTTGTGTGTGTGTGGCTGGTGGGGCGGGGGGTGGATTCT
GGTTCTTTTTTTTCCCATTATCCTGAGAGCCTTAAGGTACTCAGTGTGTTGGTGAGACTCAGCCCTGTCATCTAGCAGAAGTGTGTTCCT
TTTCATTGCTGTATAGTATTCCATTGCATGACTGTCCTGTGCTCTGATTTTAATGCACTTTATTGTGGGTGGATATTTGAGTTGCTTCCT
TTCTGGGGTAATAACACTCACTTGGAAATAGCTGTGGTGAACACTCGTGTGGGGGTGGGGGTGGGGGCCAACTCTAGGAGCACCTAATGG
ATCTTACGAAGCGTGTTGTCCAAGTATAGAGATGATTCCAAAGTGGTTGGACTGTGTTTCTTTCTCCCAGCTGGGTGGAAGGAGAACACT
AGTGGATTGCTGAGACTTGGTGCTCGGTATTTTTAATTATGGACAGCCTGGCTGGCGTTTTGTGGTGTCTAATTGCGGAGTAGCGTGTCT
TACTGTATAATGGCCTCTTTTGTATGTGGGAGACCATGGTGTTGAGGGGAGGCAGTTACACAAAAAACCCAGATACCGAGTGTTAGTTCC
ATGGGTGTGGCTGGTCATGGTGCGCACTCACGAAGGATGTAGGTGATGCCCTCCACTCCGCAGAGCCAGTCCCACAGGGGTACCCATTCT
GACTCCTACCACCGCAGCTCCCTACCTCCCGCCTGCCATGGGTTCCACGTGCATGGCTCTGGGCAGTCTGTGTCTTTGCGTGCGTCTGTG
TATGTCTGCGTGTATCTGCTTACATTCGCTCAGCATCTGAGATTCACCCAGGCTTTTGCGTGGATCAGCGGCAGACTCCTGATTGCCGCG
TGGCGGCCTGTTGTGTGGGTGTGTGCCGCGTGTGTATCCAGTCCCTACTCAGGAGTGTACGTTTCCAGTGTGGGTTGCAGTCAGGATCCA
TTTCTCCCTTAACTTTCAGATTATTTGCTGCATAGGCTTTTTTCTCCTAATTTGGCGCCTTTGTCAGAAATCAACTGACCTACCTGTGTG
GGTCTGTTTCTGTTTGTCCTTACGCTCTTGCCATTGCCACACTTTAGACAAGGTCTTGCTCTGTCCCTCAGGCTGGAGTGCAGTAGCGTG
ATCTCAGCTCACTGCACCCTTGACCTCCCATACTCCAGCAATCCCCTCGCCTCAGTCTCCTGAGTAGTAGCTGCGACCACAGGCGTGTGT
CACCACACCCGGCTGATTTTATTTTTTTTATTTTTATTTTTTTTGTAGAGACGGGGTTTTACTATGTTGCCCAGGCAGGTCTTGATCTGG
GCTCAAGTGATGCTCCTGTCTCAGCCTCCCAAACTACTGGGATTACAGGTTGTAGGTGTGAGCCATGGTGCCCGGCCGCCACACTGTCTT
GGCTACAGTTGGGTTTATAATAAACCCTGAATCGAGGTGATGTGCATTTTCCAACTCTTCTTTTTAAAGATTCTTGTGGCTGTTTATGTC
CTTGGTGTTTCCATATATGTTTTACAATCAGTGTCTCAATTTCTACCAAAAAAACATGCCTTCTGGAATTTCAATAGCAATTCCCTTGAA
CGCATTTTTGAATACCTTTTCTGAATGTCTTGAATACATGTTGGGAAGAATCGGTGTCTTAACAGTCTCCAGTGTCCACGCGTTGACTGC
CGTGTGTGACTCCAGTCGGCGTCTCAACAGTCTCCAGTGTCCACGCGTTGACTGCCGTGTGTGACTCCAGTCGGCGTCTCAGCAGTCTCC
AGTGTCCACGCGTTGACTGCCGTGTGTGACTCCAGTCGGCGTCTCAGCAGTCTCCAGTGTCCACGCGTTGACTGCCGTGTGTGACTCCAG
TCGGCGTCTCAGCAGTCTCCGGTGTCCACGCGTTGACTGCCGTGTGTGACTCCAGTCGGCGTCTCAACAGTCTCCGGTGTCCACGCGTTG
ACTGCCGTGTGTGACTCCAGTCGGCGTCTCAACAGTCTCCGGTGTCCACGCGTTGACTGCCGTGTGTGACTCCAGTCGGCGTCTCAACAG
TCTCCGGTGTCCACGCGTTGACTGCCGTGTGTGACTCCAGTCGGCGTCTCAACAGTCTCCGGTGTCCACGCGTTGACTGCCGTGTGTGAC
TCCAGTCGGCGTCTCAACAGTCTCCGGTGTCCACGCGTTGACTGCCGTGTGTGACTCCAGTCGGCGTCTCAACAGTCTCCGGTGTCCACG
CGTTGACTGCCGTGTGTGACTCCAGTCGGCGTCTCAACAGTCTCCGGTGTCCACGCGTTGACTGCCGTGTGTGACTCCAGTCGGCGTCTC
AACAGTCTCCGGTGTCCATGCGTTGACTGCCATGTATGACTCCAGGTATTGAGTTCATCTTCAACTTCTCCCAACAATGAACTGGAGTTT
TCTGTGCATGTGTCTGGCATGTTTTCCTTTAGATCTAGTCCTAGGTGTTCGATATGCTATTGAGGACTGTGTATTTTTATTTCATTTGTC
ACCTGTGCGTGGTGCTTTAATCCTGTGCCCTAAACTCCCGCCTTGGCCATGGCGGTGTTTCTGTGGACTCGTGGGGTTTCCGTGTGCACA
CGCGTGTCCTCTGTCTGACAGTGGCTTTGCTTCCCCTTGTCAGTCTGTGCCTCGGCTTCTCACTGCACTGGTGAGGTGAGCCGGCGCTCG
CTAATCTTATTCCCAGTCTCGGTGAACATGGGCTCAGTCTCTCCCGGCTCAGTGTTGGGTTTGCACTGGTGCACTTACAGGCAGAAGAGC
TTCCTCATTTGCTGAGGGCTTTTCCTGAATCCGTGTTGAATGTGGTCAGCTGCCTTTCCTGCACCTAGTGAGATGCTCATGAGGTCACTT
CCTTACCGCATTACTGTAGTGAATTACGCTGACTTTCATATGCCAAGATGACCTGGCATTTCCAGGTAAGTCCCTGTGGCCATGGTGCAT
TGGCCTTTTCTCTGCATGGCCAGATGAGATTTGCTCATACCGGGCTAAGGACCTCCTGTGTAGGAATGCTCTTGAGGGACACTGGGCTTG
GATGTTCATTGTCTTGTCATGTGATGTGTCTGTCATGGTTTGATATTGCATTAAGTGGGCCTCCTGAAACAAGTTCTGCCATAGTTTGTA
TAGGATTGGCATTATTTGTTTCATAGAGATGTGATGGGTGAGGCCATCTATGCCTGCCATTTTCTTTTTGCTTAGGTTTTTCATTAAGAA
CTTGATTTTTAAAAATAGACATGAGGCCTGGCATGGTGGCTCACGCTTGTAATCCCAGCACTTTGGGAGGCCAACGTGGATGGATCACCT
GAGGTCAGGAGTTTGAGACCAACCTAGTCAACATGGTGAAACCCCGTCTCCATTAAAAATATAAAAATTAGCAGGGTGTGGTGGTGCATG
CCTGTAATCCCAGCTACTCTGGAGGCTGAGGCAGGAGAATCACTTGAACTCAGGAGGTGGAGGTTGCAGTGAGCTGAGATCACACCACTG
CACTCCAGCCTGGGCAACAGAGCGAGGCTCTGTCTCAAAAAAAAAGACATGAGGCTTTTGGATTTTCTGTTTCTTCCTTTGTCATTTTTT
TAAAGATAGGTTTGTCGCAGAATTTCATCTAAGTTATCAAAACAATTTACATAAATCATTCACAGTATCCTCTGTGCAGTGATGTCCATT
CTCATTCCTGCTCTGGGCCATTTGTGTTTTCTTTTCCCCCTGATCAGACTAGCTAAGAGTTTATCATTTTTACAGATATTTTCCCCAAAG
AAACCTACTTTTGGGTCCATTGATTTTTTTTTTCTATTGTTTTCTTTTTCATTGACTTTTGCTCTTTTCTTATGAATTTCCTTTCTTCTA
CCTATTTTGTGTTCAATTTGCTGTCCTTGTTTTAGGTTCTTTTGATAGAGGCTTAGATCATTGATGAAGAATATGAAAGAATGGGATAAT
ACAGTTAAAAACTTGGTCTACTTATGCCCATTAGAGAAAACATTCTTAAGCACGCATGGAATCTTTTAAAAATGGACGAGGTACTAGGAC
CCAAAGCAAATGTCAGTAATTCGCAGATGATAATGTATAAATATATGATATGTAGGTAAATAATACAAATCACATTCTTTGGCCAGAGTG
CAATTGAGGAGGAAATCAGTAACAAAAAGACAATTAAATCCATTTGATTCTTTTGTTTTCGTTTTGTAGTAACTTGCACTTCCCTGGTGC
CAGAGGCATGACACCTTTTTGTCTGCTCTTGGCCATTTGGGTGGCGTCTTTGGGAAGGGCCTACTTAATTCTTTTGCCTATTTAAAAAAC
TGGGTCTTGGAAATCTTGTCTTTTTTTTTGAGTCAGGATCTTTCTCGCACAGGCTTGGAGTGCAGTGGTGCGATCATAGCTCACTGCAAC
CTCAAACTCCTGGGCTCAAGCGAGCCTCCCACCTCGGTCTTCTGAGTAGCTGGGACTACAGGCATGCATCACTATGCTCTGCTAATTTAA
AGAAAAGGTTTTTTTTATAGAGACTGGGTCTCGCTGTGTTGCCCAGGCTGGTCTCGGAGTCCTGGTCTCAAGTGATTCACCTGCCTCCAC
CTCGCGGAGTGCCAGGATTACAGGTGGCGGGAGCCGCCACACCCAGCCTGGTCTTAGCGTTATTCCCAGGTCTAGGTGTGAGTCCTTCCT
CAGATATGTGTTGTGAATAATTTCCGATCCTCTGGCTTGCTATTTTACTTTCTTAATGGTTATCTTTTGGAAAGCAAAGGTTTCCAGTTT
GATGAAATCTAATTTTTATTTTTTATTTTTCCGTTCTAGTGGTCTTTCTATTTTCTCATCAAATTGAGACTTTGGGGAAACTACACAGCA
GCAAACCAGGATATATCCTCTTAAAAACAGCTCGAGCCGGCCGGGTGCGGTGGCTCATGCCTGGAATCCCAGCACTTTGGGAGGTGGAGG
TGGGCGGATCACGTGAGGTCAGGAGTTTGAGACCAGCCTGGCCAACATGGTGAAACCCCATCTCTACTAAAAATAAAAAATTAGCCAGGC
ATGGTGGCAGGCACCTGTAATCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATGGCTTGAACCTGGGAGGCAGAGGTTGCAGTGAGCCGA

>44413_44413_3_LDLR-LRPAP1_LDLR_chr19_11200291_ENST00000545707_LRPAP1_chr4_3514763_ENST00000500728_length(amino acids)=221AA_BP=36
MADLNSQAKIQLQSKHNTPGGASSRFKHGNHARSWTRTRASSRLRHGNHAQSRTRASSRLRHGKGTTPRAGPEPLPGSDTGREPRSEPDP
SLFQAQTREGNHARSRTRASSRLRHGKGTTLGAGPEPLPGSDTGREPRSEPDPSLFQAQTREGNHAWSQTRASSRLRHRNILGAGPEQPP

--------------------------------------------------------------
>44413_44413_4_LDLR-LRPAP1_LDLR_chr19_11200291_ENST00000557933_LRPAP1_chr4_3514763_ENST00000500728_length(transcript)=6815nt_BP=154nt
AGTGCAATCGCGGGAAGCCAGGGTTTCCAGCTAGGACACAGCAGGTCGTGATCCGGGTCGGGACACTGCCTGGCAGAGGCTGCGAGCATG
GGGCCCTGGGGCTGGAAATTGCGCTGGACCGTCGCCTTGCTCCTCGCCGCGGCGGGGACTGCAGGTGAAGAAGCATCTGCAGGACCTGTC
CGGCAGGATCTCCAGAGCTCGGCACAACGAACTCTGAAGGCATTGGGGAGCCCAGCCCGGCAGGGAAGAGGCCAGCGTGAAGGACCTGGG
CTCTTGGCCGTGGCATTTCCGTGGACAGCCCGCCGTCAGGGTGGCTGGGGCTGGCACGGGTGTCGAGGCAGGAAGGATTGTTTCTGGTGA
CTGCAGCCGCTGCCGTCGCGACACAGGGCTTGGTGGTGGTAGCATTTGGGTCTGAGATCGGCCCAGCTCTGACTGAAGGGGCTTGGCTTC
CACTCAGCATCAGCGTGGCAGTCACCACCCCAGTGAGGACCTCGATGTCCAGCTGCTGTCAGGTCTGATAGTCCTCTGCTAAAACAACAC
GATTTACATAAAAAATCTTACACATCTGCCACCGGAAATACCATGCACAGAGTCCTTAAAAAATAGAGTGCAGTATTTAAACCACCCGCT
TGTTGGCTGGTCACTAAGTGTCCTGGTGGCTGGGGCCGGAGCCAGTGCTCTTGAAGGGATCGCGTCATAGCCAGCTTCCCCTCTGGGCCC
TGTGGGTCTTTGCAGCCAACCTCCTTTTCCCGTGAGACGGCCCGGCCTGATTTAAAGCCAAGAGCGCTTGAGTTGAGTTTGAGGGGAAGA
TGTGGAGCGTGTGGTTCTGTGGACAGTCAGAGACTGTGGCCTGGGGGCAGCGTCTTTCAACTCTCACCTCTGCAGCTCAGGGACCTCGGG
AGACCTCACCAAACCTGCAGGGCCTCCGTGTCCCTAAGTGTGCTGTGTAAATGCCCCATCTCATGGGGGAGAGACAGCCACGGAGGCCTT
CCTCTGACCATAGCTGATGGACTGGCGGTTGCTCAGGTCCGGCTCCGAGAATGTTCCTGTGTCTGAGCCTGGAAGAGGCTCGGGTCTGGC
TCCAGGCGTGGTTCCCTTCCCGTGTCTGAGCCTGGAAGAGGCTCGGGTCCGGCTCCGAGCGTGGTTCCCTTCCCGTGTCTGAGCCTGGAA
GAGGCTCGGGTCCGGCTCCGAGCGTGGTTCCCTTCCCGTGTCTGAGCCTGGAAGAGGCTCGGGTCCGGCTCCGAGCGTGGTTCCCTTCCC
GTGTCTGAGCCTGGAAGAGGCTCGGGTCCGGCTCCGAGCGTGGTTCCCTTCCCGTGTCTGAGCCTGGAAGAGGCTCGGGTCCGGCTCTGG
GCGTGGTTCCCTTCCCGTGTCTGAGCCTGGAAGAGGCTCGGGTCCGGCTCTGGGCGTGGTTCCCGTGTCTGAGCCTGGAAGAGGCTCGGG
TCCGGGTCCAGCTCCGAGCGTGGTTCCCGTGTTTGAACCTGGAAGAGGCTCCACCAGGCGTATTGTGTTTTGACTGCAGCTGGATCTTGG
CTTGACTGTTGAGATCTGCCAAACATCCGCTAAGCTATCATTTCTGAGAAAGGTCAAGGCTAGAGGCAGCATGTCGGGAGTTGGCGCATC
AGGGTTGGAAGGGCCCCAGGGTACAGCATGTGGGTGCCTGTTCCTTTGTGGACTTGTGTGTGTGTGGCTGGTGGGGCGGGGGGTGGATTC
TGGTTCTTTTTTTTCCCATTATCCTGAGAGCCTTAAGGTACTCAGTGTGTTGGTGAGACTCAGCCCTGTCATCTAGCAGAAGTGTGTTCC
TTTTCATTGCTGTATAGTATTCCATTGCATGACTGTCCTGTGCTCTGATTTTAATGCACTTTATTGTGGGTGGATATTTGAGTTGCTTCC
TTTCTGGGGTAATAACACTCACTTGGAAATAGCTGTGGTGAACACTCGTGTGGGGGTGGGGGTGGGGGCCAACTCTAGGAGCACCTAATG
GATCTTACGAAGCGTGTTGTCCAAGTATAGAGATGATTCCAAAGTGGTTGGACTGTGTTTCTTTCTCCCAGCTGGGTGGAAGGAGAACAC
TAGTGGATTGCTGAGACTTGGTGCTCGGTATTTTTAATTATGGACAGCCTGGCTGGCGTTTTGTGGTGTCTAATTGCGGAGTAGCGTGTC
TTACTGTATAATGGCCTCTTTTGTATGTGGGAGACCATGGTGTTGAGGGGAGGCAGTTACACAAAAAACCCAGATACCGAGTGTTAGTTC
CATGGGTGTGGCTGGTCATGGTGCGCACTCACGAAGGATGTAGGTGATGCCCTCCACTCCGCAGAGCCAGTCCCACAGGGGTACCCATTC
TGACTCCTACCACCGCAGCTCCCTACCTCCCGCCTGCCATGGGTTCCACGTGCATGGCTCTGGGCAGTCTGTGTCTTTGCGTGCGTCTGT
GTATGTCTGCGTGTATCTGCTTACATTCGCTCAGCATCTGAGATTCACCCAGGCTTTTGCGTGGATCAGCGGCAGACTCCTGATTGCCGC
GTGGCGGCCTGTTGTGTGGGTGTGTGCCGCGTGTGTATCCAGTCCCTACTCAGGAGTGTACGTTTCCAGTGTGGGTTGCAGTCAGGATCC
ATTTCTCCCTTAACTTTCAGATTATTTGCTGCATAGGCTTTTTTCTCCTAATTTGGCGCCTTTGTCAGAAATCAACTGACCTACCTGTGT
GGGTCTGTTTCTGTTTGTCCTTACGCTCTTGCCATTGCCACACTTTAGACAAGGTCTTGCTCTGTCCCTCAGGCTGGAGTGCAGTAGCGT
GATCTCAGCTCACTGCACCCTTGACCTCCCATACTCCAGCAATCCCCTCGCCTCAGTCTCCTGAGTAGTAGCTGCGACCACAGGCGTGTG
TCACCACACCCGGCTGATTTTATTTTTTTTATTTTTATTTTTTTTGTAGAGACGGGGTTTTACTATGTTGCCCAGGCAGGTCTTGATCTG
GGCTCAAGTGATGCTCCTGTCTCAGCCTCCCAAACTACTGGGATTACAGGTTGTAGGTGTGAGCCATGGTGCCCGGCCGCCACACTGTCT
TGGCTACAGTTGGGTTTATAATAAACCCTGAATCGAGGTGATGTGCATTTTCCAACTCTTCTTTTTAAAGATTCTTGTGGCTGTTTATGT
CCTTGGTGTTTCCATATATGTTTTACAATCAGTGTCTCAATTTCTACCAAAAAAACATGCCTTCTGGAATTTCAATAGCAATTCCCTTGA
ACGCATTTTTGAATACCTTTTCTGAATGTCTTGAATACATGTTGGGAAGAATCGGTGTCTTAACAGTCTCCAGTGTCCACGCGTTGACTG
CCGTGTGTGACTCCAGTCGGCGTCTCAACAGTCTCCAGTGTCCACGCGTTGACTGCCGTGTGTGACTCCAGTCGGCGTCTCAGCAGTCTC
CAGTGTCCACGCGTTGACTGCCGTGTGTGACTCCAGTCGGCGTCTCAGCAGTCTCCAGTGTCCACGCGTTGACTGCCGTGTGTGACTCCA
GTCGGCGTCTCAGCAGTCTCCGGTGTCCACGCGTTGACTGCCGTGTGTGACTCCAGTCGGCGTCTCAACAGTCTCCGGTGTCCACGCGTT
GACTGCCGTGTGTGACTCCAGTCGGCGTCTCAACAGTCTCCGGTGTCCACGCGTTGACTGCCGTGTGTGACTCCAGTCGGCGTCTCAACA
GTCTCCGGTGTCCACGCGTTGACTGCCGTGTGTGACTCCAGTCGGCGTCTCAACAGTCTCCGGTGTCCACGCGTTGACTGCCGTGTGTGA
CTCCAGTCGGCGTCTCAACAGTCTCCGGTGTCCACGCGTTGACTGCCGTGTGTGACTCCAGTCGGCGTCTCAACAGTCTCCGGTGTCCAC
GCGTTGACTGCCGTGTGTGACTCCAGTCGGCGTCTCAACAGTCTCCGGTGTCCACGCGTTGACTGCCGTGTGTGACTCCAGTCGGCGTCT
CAACAGTCTCCGGTGTCCATGCGTTGACTGCCATGTATGACTCCAGGTATTGAGTTCATCTTCAACTTCTCCCAACAATGAACTGGAGTT
TTCTGTGCATGTGTCTGGCATGTTTTCCTTTAGATCTAGTCCTAGGTGTTCGATATGCTATTGAGGACTGTGTATTTTTATTTCATTTGT
CACCTGTGCGTGGTGCTTTAATCCTGTGCCCTAAACTCCCGCCTTGGCCATGGCGGTGTTTCTGTGGACTCGTGGGGTTTCCGTGTGCAC
ACGCGTGTCCTCTGTCTGACAGTGGCTTTGCTTCCCCTTGTCAGTCTGTGCCTCGGCTTCTCACTGCACTGGTGAGGTGAGCCGGCGCTC
GCTAATCTTATTCCCAGTCTCGGTGAACATGGGCTCAGTCTCTCCCGGCTCAGTGTTGGGTTTGCACTGGTGCACTTACAGGCAGAAGAG
CTTCCTCATTTGCTGAGGGCTTTTCCTGAATCCGTGTTGAATGTGGTCAGCTGCCTTTCCTGCACCTAGTGAGATGCTCATGAGGTCACT
TCCTTACCGCATTACTGTAGTGAATTACGCTGACTTTCATATGCCAAGATGACCTGGCATTTCCAGGTAAGTCCCTGTGGCCATGGTGCA
TTGGCCTTTTCTCTGCATGGCCAGATGAGATTTGCTCATACCGGGCTAAGGACCTCCTGTGTAGGAATGCTCTTGAGGGACACTGGGCTT
GGATGTTCATTGTCTTGTCATGTGATGTGTCTGTCATGGTTTGATATTGCATTAAGTGGGCCTCCTGAAACAAGTTCTGCCATAGTTTGT
ATAGGATTGGCATTATTTGTTTCATAGAGATGTGATGGGTGAGGCCATCTATGCCTGCCATTTTCTTTTTGCTTAGGTTTTTCATTAAGA
ACTTGATTTTTAAAAATAGACATGAGGCCTGGCATGGTGGCTCACGCTTGTAATCCCAGCACTTTGGGAGGCCAACGTGGATGGATCACC
TGAGGTCAGGAGTTTGAGACCAACCTAGTCAACATGGTGAAACCCCGTCTCCATTAAAAATATAAAAATTAGCAGGGTGTGGTGGTGCAT
GCCTGTAATCCCAGCTACTCTGGAGGCTGAGGCAGGAGAATCACTTGAACTCAGGAGGTGGAGGTTGCAGTGAGCTGAGATCACACCACT
GCACTCCAGCCTGGGCAACAGAGCGAGGCTCTGTCTCAAAAAAAAAGACATGAGGCTTTTGGATTTTCTGTTTCTTCCTTTGTCATTTTT
TTAAAGATAGGTTTGTCGCAGAATTTCATCTAAGTTATCAAAACAATTTACATAAATCATTCACAGTATCCTCTGTGCAGTGATGTCCAT
TCTCATTCCTGCTCTGGGCCATTTGTGTTTTCTTTTCCCCCTGATCAGACTAGCTAAGAGTTTATCATTTTTACAGATATTTTCCCCAAA
GAAACCTACTTTTGGGTCCATTGATTTTTTTTTTCTATTGTTTTCTTTTTCATTGACTTTTGCTCTTTTCTTATGAATTTCCTTTCTTCT
ACCTATTTTGTGTTCAATTTGCTGTCCTTGTTTTAGGTTCTTTTGATAGAGGCTTAGATCATTGATGAAGAATATGAAAGAATGGGATAA
TACAGTTAAAAACTTGGTCTACTTATGCCCATTAGAGAAAACATTCTTAAGCACGCATGGAATCTTTTAAAAATGGACGAGGTACTAGGA
CCCAAAGCAAATGTCAGTAATTCGCAGATGATAATGTATAAATATATGATATGTAGGTAAATAATACAAATCACATTCTTTGGCCAGAGT
GCAATTGAGGAGGAAATCAGTAACAAAAAGACAATTAAATCCATTTGATTCTTTTGTTTTCGTTTTGTAGTAACTTGCACTTCCCTGGTG
CCAGAGGCATGACACCTTTTTGTCTGCTCTTGGCCATTTGGGTGGCGTCTTTGGGAAGGGCCTACTTAATTCTTTTGCCTATTTAAAAAA
CTGGGTCTTGGAAATCTTGTCTTTTTTTTTGAGTCAGGATCTTTCTCGCACAGGCTTGGAGTGCAGTGGTGCGATCATAGCTCACTGCAA
CCTCAAACTCCTGGGCTCAAGCGAGCCTCCCACCTCGGTCTTCTGAGTAGCTGGGACTACAGGCATGCATCACTATGCTCTGCTAATTTA
AAGAAAAGGTTTTTTTTATAGAGACTGGGTCTCGCTGTGTTGCCCAGGCTGGTCTCGGAGTCCTGGTCTCAAGTGATTCACCTGCCTCCA
CCTCGCGGAGTGCCAGGATTACAGGTGGCGGGAGCCGCCACACCCAGCCTGGTCTTAGCGTTATTCCCAGGTCTAGGTGTGAGTCCTTCC
TCAGATATGTGTTGTGAATAATTTCCGATCCTCTGGCTTGCTATTTTACTTTCTTAATGGTTATCTTTTGGAAAGCAAAGGTTTCCAGTT
TGATGAAATCTAATTTTTATTTTTTATTTTTCCGTTCTAGTGGTCTTTCTATTTTCTCATCAAATTGAGACTTTGGGGAAACTACACAGC
AGCAAACCAGGATATATCCTCTTAAAAACAGCTCGAGCCGGCCGGGTGCGGTGGCTCATGCCTGGAATCCCAGCACTTTGGGAGGTGGAG
GTGGGCGGATCACGTGAGGTCAGGAGTTTGAGACCAGCCTGGCCAACATGGTGAAACCCCATCTCTACTAAAAATAAAAAATTAGCCAGG
CATGGTGGCAGGCACCTGTAATCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATGGCTTGAACCTGGGAGGCAGAGGTTGCAGTGAGCCG

>44413_44413_4_LDLR-LRPAP1_LDLR_chr19_11200291_ENST00000557933_LRPAP1_chr4_3514763_ENST00000500728_length(amino acids)=221AA_BP=36
MADLNSQAKIQLQSKHNTPGGASSRFKHGNHARSWTRTRASSRLRHGNHAQSRTRASSRLRHGKGTTPRAGPEPLPGSDTGREPRSEPDP
SLFQAQTREGNHARSRTRASSRLRHGKGTTLGAGPEPLPGSDTGREPRSEPDPSLFQAQTREGNHAWSQTRASSRLRHRNILGAGPEQPP

--------------------------------------------------------------
>44413_44413_5_LDLR-LRPAP1_LDLR_chr19_11200291_ENST00000558013_LRPAP1_chr4_3514763_ENST00000500728_length(transcript)=6799nt_BP=138nt
GCCAGGGTTTCCAGCTAGGACACAGCAGGTCGTGATCCGGGTCGGGACACTGCCTGGCAGAGGCTGCGAGCATGGGGCCCTGGGGCTGGA
AATTGCGCTGGACCGTCGCCTTGCTCCTCGCCGCGGCGGGGACTGCAGGTGAAGAAGCATCTGCAGGACCTGTCCGGCAGGATCTCCAGA
GCTCGGCACAACGAACTCTGAAGGCATTGGGGAGCCCAGCCCGGCAGGGAAGAGGCCAGCGTGAAGGACCTGGGCTCTTGGCCGTGGCAT
TTCCGTGGACAGCCCGCCGTCAGGGTGGCTGGGGCTGGCACGGGTGTCGAGGCAGGAAGGATTGTTTCTGGTGACTGCAGCCGCTGCCGT
CGCGACACAGGGCTTGGTGGTGGTAGCATTTGGGTCTGAGATCGGCCCAGCTCTGACTGAAGGGGCTTGGCTTCCACTCAGCATCAGCGT
GGCAGTCACCACCCCAGTGAGGACCTCGATGTCCAGCTGCTGTCAGGTCTGATAGTCCTCTGCTAAAACAACACGATTTACATAAAAAAT
CTTACACATCTGCCACCGGAAATACCATGCACAGAGTCCTTAAAAAATAGAGTGCAGTATTTAAACCACCCGCTTGTTGGCTGGTCACTA
AGTGTCCTGGTGGCTGGGGCCGGAGCCAGTGCTCTTGAAGGGATCGCGTCATAGCCAGCTTCCCCTCTGGGCCCTGTGGGTCTTTGCAGC
CAACCTCCTTTTCCCGTGAGACGGCCCGGCCTGATTTAAAGCCAAGAGCGCTTGAGTTGAGTTTGAGGGGAAGATGTGGAGCGTGTGGTT
CTGTGGACAGTCAGAGACTGTGGCCTGGGGGCAGCGTCTTTCAACTCTCACCTCTGCAGCTCAGGGACCTCGGGAGACCTCACCAAACCT
GCAGGGCCTCCGTGTCCCTAAGTGTGCTGTGTAAATGCCCCATCTCATGGGGGAGAGACAGCCACGGAGGCCTTCCTCTGACCATAGCTG
ATGGACTGGCGGTTGCTCAGGTCCGGCTCCGAGAATGTTCCTGTGTCTGAGCCTGGAAGAGGCTCGGGTCTGGCTCCAGGCGTGGTTCCC
TTCCCGTGTCTGAGCCTGGAAGAGGCTCGGGTCCGGCTCCGAGCGTGGTTCCCTTCCCGTGTCTGAGCCTGGAAGAGGCTCGGGTCCGGC
TCCGAGCGTGGTTCCCTTCCCGTGTCTGAGCCTGGAAGAGGCTCGGGTCCGGCTCCGAGCGTGGTTCCCTTCCCGTGTCTGAGCCTGGAA
GAGGCTCGGGTCCGGCTCCGAGCGTGGTTCCCTTCCCGTGTCTGAGCCTGGAAGAGGCTCGGGTCCGGCTCTGGGCGTGGTTCCCTTCCC
GTGTCTGAGCCTGGAAGAGGCTCGGGTCCGGCTCTGGGCGTGGTTCCCGTGTCTGAGCCTGGAAGAGGCTCGGGTCCGGGTCCAGCTCCG
AGCGTGGTTCCCGTGTTTGAACCTGGAAGAGGCTCCACCAGGCGTATTGTGTTTTGACTGCAGCTGGATCTTGGCTTGACTGTTGAGATC
TGCCAAACATCCGCTAAGCTATCATTTCTGAGAAAGGTCAAGGCTAGAGGCAGCATGTCGGGAGTTGGCGCATCAGGGTTGGAAGGGCCC
CAGGGTACAGCATGTGGGTGCCTGTTCCTTTGTGGACTTGTGTGTGTGTGGCTGGTGGGGCGGGGGGTGGATTCTGGTTCTTTTTTTTCC
CATTATCCTGAGAGCCTTAAGGTACTCAGTGTGTTGGTGAGACTCAGCCCTGTCATCTAGCAGAAGTGTGTTCCTTTTCATTGCTGTATA
GTATTCCATTGCATGACTGTCCTGTGCTCTGATTTTAATGCACTTTATTGTGGGTGGATATTTGAGTTGCTTCCTTTCTGGGGTAATAAC
ACTCACTTGGAAATAGCTGTGGTGAACACTCGTGTGGGGGTGGGGGTGGGGGCCAACTCTAGGAGCACCTAATGGATCTTACGAAGCGTG
TTGTCCAAGTATAGAGATGATTCCAAAGTGGTTGGACTGTGTTTCTTTCTCCCAGCTGGGTGGAAGGAGAACACTAGTGGATTGCTGAGA
CTTGGTGCTCGGTATTTTTAATTATGGACAGCCTGGCTGGCGTTTTGTGGTGTCTAATTGCGGAGTAGCGTGTCTTACTGTATAATGGCC
TCTTTTGTATGTGGGAGACCATGGTGTTGAGGGGAGGCAGTTACACAAAAAACCCAGATACCGAGTGTTAGTTCCATGGGTGTGGCTGGT
CATGGTGCGCACTCACGAAGGATGTAGGTGATGCCCTCCACTCCGCAGAGCCAGTCCCACAGGGGTACCCATTCTGACTCCTACCACCGC
AGCTCCCTACCTCCCGCCTGCCATGGGTTCCACGTGCATGGCTCTGGGCAGTCTGTGTCTTTGCGTGCGTCTGTGTATGTCTGCGTGTAT
CTGCTTACATTCGCTCAGCATCTGAGATTCACCCAGGCTTTTGCGTGGATCAGCGGCAGACTCCTGATTGCCGCGTGGCGGCCTGTTGTG
TGGGTGTGTGCCGCGTGTGTATCCAGTCCCTACTCAGGAGTGTACGTTTCCAGTGTGGGTTGCAGTCAGGATCCATTTCTCCCTTAACTT
TCAGATTATTTGCTGCATAGGCTTTTTTCTCCTAATTTGGCGCCTTTGTCAGAAATCAACTGACCTACCTGTGTGGGTCTGTTTCTGTTT
GTCCTTACGCTCTTGCCATTGCCACACTTTAGACAAGGTCTTGCTCTGTCCCTCAGGCTGGAGTGCAGTAGCGTGATCTCAGCTCACTGC
ACCCTTGACCTCCCATACTCCAGCAATCCCCTCGCCTCAGTCTCCTGAGTAGTAGCTGCGACCACAGGCGTGTGTCACCACACCCGGCTG
ATTTTATTTTTTTTATTTTTATTTTTTTTGTAGAGACGGGGTTTTACTATGTTGCCCAGGCAGGTCTTGATCTGGGCTCAAGTGATGCTC
CTGTCTCAGCCTCCCAAACTACTGGGATTACAGGTTGTAGGTGTGAGCCATGGTGCCCGGCCGCCACACTGTCTTGGCTACAGTTGGGTT
TATAATAAACCCTGAATCGAGGTGATGTGCATTTTCCAACTCTTCTTTTTAAAGATTCTTGTGGCTGTTTATGTCCTTGGTGTTTCCATA
TATGTTTTACAATCAGTGTCTCAATTTCTACCAAAAAAACATGCCTTCTGGAATTTCAATAGCAATTCCCTTGAACGCATTTTTGAATAC
CTTTTCTGAATGTCTTGAATACATGTTGGGAAGAATCGGTGTCTTAACAGTCTCCAGTGTCCACGCGTTGACTGCCGTGTGTGACTCCAG
TCGGCGTCTCAACAGTCTCCAGTGTCCACGCGTTGACTGCCGTGTGTGACTCCAGTCGGCGTCTCAGCAGTCTCCAGTGTCCACGCGTTG
ACTGCCGTGTGTGACTCCAGTCGGCGTCTCAGCAGTCTCCAGTGTCCACGCGTTGACTGCCGTGTGTGACTCCAGTCGGCGTCTCAGCAG
TCTCCGGTGTCCACGCGTTGACTGCCGTGTGTGACTCCAGTCGGCGTCTCAACAGTCTCCGGTGTCCACGCGTTGACTGCCGTGTGTGAC
TCCAGTCGGCGTCTCAACAGTCTCCGGTGTCCACGCGTTGACTGCCGTGTGTGACTCCAGTCGGCGTCTCAACAGTCTCCGGTGTCCACG
CGTTGACTGCCGTGTGTGACTCCAGTCGGCGTCTCAACAGTCTCCGGTGTCCACGCGTTGACTGCCGTGTGTGACTCCAGTCGGCGTCTC
AACAGTCTCCGGTGTCCACGCGTTGACTGCCGTGTGTGACTCCAGTCGGCGTCTCAACAGTCTCCGGTGTCCACGCGTTGACTGCCGTGT
GTGACTCCAGTCGGCGTCTCAACAGTCTCCGGTGTCCACGCGTTGACTGCCGTGTGTGACTCCAGTCGGCGTCTCAACAGTCTCCGGTGT
CCATGCGTTGACTGCCATGTATGACTCCAGGTATTGAGTTCATCTTCAACTTCTCCCAACAATGAACTGGAGTTTTCTGTGCATGTGTCT
GGCATGTTTTCCTTTAGATCTAGTCCTAGGTGTTCGATATGCTATTGAGGACTGTGTATTTTTATTTCATTTGTCACCTGTGCGTGGTGC
TTTAATCCTGTGCCCTAAACTCCCGCCTTGGCCATGGCGGTGTTTCTGTGGACTCGTGGGGTTTCCGTGTGCACACGCGTGTCCTCTGTC
TGACAGTGGCTTTGCTTCCCCTTGTCAGTCTGTGCCTCGGCTTCTCACTGCACTGGTGAGGTGAGCCGGCGCTCGCTAATCTTATTCCCA
GTCTCGGTGAACATGGGCTCAGTCTCTCCCGGCTCAGTGTTGGGTTTGCACTGGTGCACTTACAGGCAGAAGAGCTTCCTCATTTGCTGA
GGGCTTTTCCTGAATCCGTGTTGAATGTGGTCAGCTGCCTTTCCTGCACCTAGTGAGATGCTCATGAGGTCACTTCCTTACCGCATTACT
GTAGTGAATTACGCTGACTTTCATATGCCAAGATGACCTGGCATTTCCAGGTAAGTCCCTGTGGCCATGGTGCATTGGCCTTTTCTCTGC
ATGGCCAGATGAGATTTGCTCATACCGGGCTAAGGACCTCCTGTGTAGGAATGCTCTTGAGGGACACTGGGCTTGGATGTTCATTGTCTT
GTCATGTGATGTGTCTGTCATGGTTTGATATTGCATTAAGTGGGCCTCCTGAAACAAGTTCTGCCATAGTTTGTATAGGATTGGCATTAT
TTGTTTCATAGAGATGTGATGGGTGAGGCCATCTATGCCTGCCATTTTCTTTTTGCTTAGGTTTTTCATTAAGAACTTGATTTTTAAAAA
TAGACATGAGGCCTGGCATGGTGGCTCACGCTTGTAATCCCAGCACTTTGGGAGGCCAACGTGGATGGATCACCTGAGGTCAGGAGTTTG
AGACCAACCTAGTCAACATGGTGAAACCCCGTCTCCATTAAAAATATAAAAATTAGCAGGGTGTGGTGGTGCATGCCTGTAATCCCAGCT
ACTCTGGAGGCTGAGGCAGGAGAATCACTTGAACTCAGGAGGTGGAGGTTGCAGTGAGCTGAGATCACACCACTGCACTCCAGCCTGGGC
AACAGAGCGAGGCTCTGTCTCAAAAAAAAAGACATGAGGCTTTTGGATTTTCTGTTTCTTCCTTTGTCATTTTTTTAAAGATAGGTTTGT
CGCAGAATTTCATCTAAGTTATCAAAACAATTTACATAAATCATTCACAGTATCCTCTGTGCAGTGATGTCCATTCTCATTCCTGCTCTG
GGCCATTTGTGTTTTCTTTTCCCCCTGATCAGACTAGCTAAGAGTTTATCATTTTTACAGATATTTTCCCCAAAGAAACCTACTTTTGGG
TCCATTGATTTTTTTTTTCTATTGTTTTCTTTTTCATTGACTTTTGCTCTTTTCTTATGAATTTCCTTTCTTCTACCTATTTTGTGTTCA
ATTTGCTGTCCTTGTTTTAGGTTCTTTTGATAGAGGCTTAGATCATTGATGAAGAATATGAAAGAATGGGATAATACAGTTAAAAACTTG
GTCTACTTATGCCCATTAGAGAAAACATTCTTAAGCACGCATGGAATCTTTTAAAAATGGACGAGGTACTAGGACCCAAAGCAAATGTCA
GTAATTCGCAGATGATAATGTATAAATATATGATATGTAGGTAAATAATACAAATCACATTCTTTGGCCAGAGTGCAATTGAGGAGGAAA
TCAGTAACAAAAAGACAATTAAATCCATTTGATTCTTTTGTTTTCGTTTTGTAGTAACTTGCACTTCCCTGGTGCCAGAGGCATGACACC
TTTTTGTCTGCTCTTGGCCATTTGGGTGGCGTCTTTGGGAAGGGCCTACTTAATTCTTTTGCCTATTTAAAAAACTGGGTCTTGGAAATC
TTGTCTTTTTTTTTGAGTCAGGATCTTTCTCGCACAGGCTTGGAGTGCAGTGGTGCGATCATAGCTCACTGCAACCTCAAACTCCTGGGC
TCAAGCGAGCCTCCCACCTCGGTCTTCTGAGTAGCTGGGACTACAGGCATGCATCACTATGCTCTGCTAATTTAAAGAAAAGGTTTTTTT
TATAGAGACTGGGTCTCGCTGTGTTGCCCAGGCTGGTCTCGGAGTCCTGGTCTCAAGTGATTCACCTGCCTCCACCTCGCGGAGTGCCAG
GATTACAGGTGGCGGGAGCCGCCACACCCAGCCTGGTCTTAGCGTTATTCCCAGGTCTAGGTGTGAGTCCTTCCTCAGATATGTGTTGTG
AATAATTTCCGATCCTCTGGCTTGCTATTTTACTTTCTTAATGGTTATCTTTTGGAAAGCAAAGGTTTCCAGTTTGATGAAATCTAATTT
TTATTTTTTATTTTTCCGTTCTAGTGGTCTTTCTATTTTCTCATCAAATTGAGACTTTGGGGAAACTACACAGCAGCAAACCAGGATATA
TCCTCTTAAAAACAGCTCGAGCCGGCCGGGTGCGGTGGCTCATGCCTGGAATCCCAGCACTTTGGGAGGTGGAGGTGGGCGGATCACGTG
AGGTCAGGAGTTTGAGACCAGCCTGGCCAACATGGTGAAACCCCATCTCTACTAAAAATAAAAAATTAGCCAGGCATGGTGGCAGGCACC
TGTAATCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATGGCTTGAACCTGGGAGGCAGAGGTTGCAGTGAGCCGAGATCGCGCCATTGCA

>44413_44413_5_LDLR-LRPAP1_LDLR_chr19_11200291_ENST00000558013_LRPAP1_chr4_3514763_ENST00000500728_length(amino acids)=221AA_BP=36
MADLNSQAKIQLQSKHNTPGGASSRFKHGNHARSWTRTRASSRLRHGNHAQSRTRASSRLRHGKGTTPRAGPEPLPGSDTGREPRSEPDP
SLFQAQTREGNHARSRTRASSRLRHGKGTTLGAGPEPLPGSDTGREPRSEPDPSLFQAQTREGNHAWSQTRASSRLRHRNILGAGPEQPP

--------------------------------------------------------------
>44413_44413_6_LDLR-LRPAP1_LDLR_chr19_11200291_ENST00000558518_LRPAP1_chr4_3514763_ENST00000500728_length(transcript)=6915nt_BP=254nt
CTCTTGCAGTGAGGTGAAGACATTTGAAAATCACCCCACTGCAAACTCCTCCCCCTGCTAGAAACCTCACATTGAAATGCTGTAAATGAC
GTGGGCCCCGAGTGCAATCGCGGGAAGCCAGGGTTTCCAGCTAGGACACAGCAGGTCGTGATCCGGGTCGGGACACTGCCTGGCAGAGGC
TGCGAGCATGGGGCCCTGGGGCTGGAAATTGCGCTGGACCGTCGCCTTGCTCCTCGCCGCGGCGGGGACTGCAGGTGAAGAAGCATCTGC
AGGACCTGTCCGGCAGGATCTCCAGAGCTCGGCACAACGAACTCTGAAGGCATTGGGGAGCCCAGCCCGGCAGGGAAGAGGCCAGCGTGA
AGGACCTGGGCTCTTGGCCGTGGCATTTCCGTGGACAGCCCGCCGTCAGGGTGGCTGGGGCTGGCACGGGTGTCGAGGCAGGAAGGATTG
TTTCTGGTGACTGCAGCCGCTGCCGTCGCGACACAGGGCTTGGTGGTGGTAGCATTTGGGTCTGAGATCGGCCCAGCTCTGACTGAAGGG
GCTTGGCTTCCACTCAGCATCAGCGTGGCAGTCACCACCCCAGTGAGGACCTCGATGTCCAGCTGCTGTCAGGTCTGATAGTCCTCTGCT
AAAACAACACGATTTACATAAAAAATCTTACACATCTGCCACCGGAAATACCATGCACAGAGTCCTTAAAAAATAGAGTGCAGTATTTAA
ACCACCCGCTTGTTGGCTGGTCACTAAGTGTCCTGGTGGCTGGGGCCGGAGCCAGTGCTCTTGAAGGGATCGCGTCATAGCCAGCTTCCC
CTCTGGGCCCTGTGGGTCTTTGCAGCCAACCTCCTTTTCCCGTGAGACGGCCCGGCCTGATTTAAAGCCAAGAGCGCTTGAGTTGAGTTT
GAGGGGAAGATGTGGAGCGTGTGGTTCTGTGGACAGTCAGAGACTGTGGCCTGGGGGCAGCGTCTTTCAACTCTCACCTCTGCAGCTCAG
GGACCTCGGGAGACCTCACCAAACCTGCAGGGCCTCCGTGTCCCTAAGTGTGCTGTGTAAATGCCCCATCTCATGGGGGAGAGACAGCCA
CGGAGGCCTTCCTCTGACCATAGCTGATGGACTGGCGGTTGCTCAGGTCCGGCTCCGAGAATGTTCCTGTGTCTGAGCCTGGAAGAGGCT
CGGGTCTGGCTCCAGGCGTGGTTCCCTTCCCGTGTCTGAGCCTGGAAGAGGCTCGGGTCCGGCTCCGAGCGTGGTTCCCTTCCCGTGTCT
GAGCCTGGAAGAGGCTCGGGTCCGGCTCCGAGCGTGGTTCCCTTCCCGTGTCTGAGCCTGGAAGAGGCTCGGGTCCGGCTCCGAGCGTGG
TTCCCTTCCCGTGTCTGAGCCTGGAAGAGGCTCGGGTCCGGCTCCGAGCGTGGTTCCCTTCCCGTGTCTGAGCCTGGAAGAGGCTCGGGT
CCGGCTCTGGGCGTGGTTCCCTTCCCGTGTCTGAGCCTGGAAGAGGCTCGGGTCCGGCTCTGGGCGTGGTTCCCGTGTCTGAGCCTGGAA
GAGGCTCGGGTCCGGGTCCAGCTCCGAGCGTGGTTCCCGTGTTTGAACCTGGAAGAGGCTCCACCAGGCGTATTGTGTTTTGACTGCAGC
TGGATCTTGGCTTGACTGTTGAGATCTGCCAAACATCCGCTAAGCTATCATTTCTGAGAAAGGTCAAGGCTAGAGGCAGCATGTCGGGAG
TTGGCGCATCAGGGTTGGAAGGGCCCCAGGGTACAGCATGTGGGTGCCTGTTCCTTTGTGGACTTGTGTGTGTGTGGCTGGTGGGGCGGG
GGGTGGATTCTGGTTCTTTTTTTTCCCATTATCCTGAGAGCCTTAAGGTACTCAGTGTGTTGGTGAGACTCAGCCCTGTCATCTAGCAGA
AGTGTGTTCCTTTTCATTGCTGTATAGTATTCCATTGCATGACTGTCCTGTGCTCTGATTTTAATGCACTTTATTGTGGGTGGATATTTG
AGTTGCTTCCTTTCTGGGGTAATAACACTCACTTGGAAATAGCTGTGGTGAACACTCGTGTGGGGGTGGGGGTGGGGGCCAACTCTAGGA
GCACCTAATGGATCTTACGAAGCGTGTTGTCCAAGTATAGAGATGATTCCAAAGTGGTTGGACTGTGTTTCTTTCTCCCAGCTGGGTGGA
AGGAGAACACTAGTGGATTGCTGAGACTTGGTGCTCGGTATTTTTAATTATGGACAGCCTGGCTGGCGTTTTGTGGTGTCTAATTGCGGA
GTAGCGTGTCTTACTGTATAATGGCCTCTTTTGTATGTGGGAGACCATGGTGTTGAGGGGAGGCAGTTACACAAAAAACCCAGATACCGA
GTGTTAGTTCCATGGGTGTGGCTGGTCATGGTGCGCACTCACGAAGGATGTAGGTGATGCCCTCCACTCCGCAGAGCCAGTCCCACAGGG
GTACCCATTCTGACTCCTACCACCGCAGCTCCCTACCTCCCGCCTGCCATGGGTTCCACGTGCATGGCTCTGGGCAGTCTGTGTCTTTGC
GTGCGTCTGTGTATGTCTGCGTGTATCTGCTTACATTCGCTCAGCATCTGAGATTCACCCAGGCTTTTGCGTGGATCAGCGGCAGACTCC
TGATTGCCGCGTGGCGGCCTGTTGTGTGGGTGTGTGCCGCGTGTGTATCCAGTCCCTACTCAGGAGTGTACGTTTCCAGTGTGGGTTGCA
GTCAGGATCCATTTCTCCCTTAACTTTCAGATTATTTGCTGCATAGGCTTTTTTCTCCTAATTTGGCGCCTTTGTCAGAAATCAACTGAC
CTACCTGTGTGGGTCTGTTTCTGTTTGTCCTTACGCTCTTGCCATTGCCACACTTTAGACAAGGTCTTGCTCTGTCCCTCAGGCTGGAGT
GCAGTAGCGTGATCTCAGCTCACTGCACCCTTGACCTCCCATACTCCAGCAATCCCCTCGCCTCAGTCTCCTGAGTAGTAGCTGCGACCA
CAGGCGTGTGTCACCACACCCGGCTGATTTTATTTTTTTTATTTTTATTTTTTTTGTAGAGACGGGGTTTTACTATGTTGCCCAGGCAGG
TCTTGATCTGGGCTCAAGTGATGCTCCTGTCTCAGCCTCCCAAACTACTGGGATTACAGGTTGTAGGTGTGAGCCATGGTGCCCGGCCGC
CACACTGTCTTGGCTACAGTTGGGTTTATAATAAACCCTGAATCGAGGTGATGTGCATTTTCCAACTCTTCTTTTTAAAGATTCTTGTGG
CTGTTTATGTCCTTGGTGTTTCCATATATGTTTTACAATCAGTGTCTCAATTTCTACCAAAAAAACATGCCTTCTGGAATTTCAATAGCA
ATTCCCTTGAACGCATTTTTGAATACCTTTTCTGAATGTCTTGAATACATGTTGGGAAGAATCGGTGTCTTAACAGTCTCCAGTGTCCAC
GCGTTGACTGCCGTGTGTGACTCCAGTCGGCGTCTCAACAGTCTCCAGTGTCCACGCGTTGACTGCCGTGTGTGACTCCAGTCGGCGTCT
CAGCAGTCTCCAGTGTCCACGCGTTGACTGCCGTGTGTGACTCCAGTCGGCGTCTCAGCAGTCTCCAGTGTCCACGCGTTGACTGCCGTG
TGTGACTCCAGTCGGCGTCTCAGCAGTCTCCGGTGTCCACGCGTTGACTGCCGTGTGTGACTCCAGTCGGCGTCTCAACAGTCTCCGGTG
TCCACGCGTTGACTGCCGTGTGTGACTCCAGTCGGCGTCTCAACAGTCTCCGGTGTCCACGCGTTGACTGCCGTGTGTGACTCCAGTCGG
CGTCTCAACAGTCTCCGGTGTCCACGCGTTGACTGCCGTGTGTGACTCCAGTCGGCGTCTCAACAGTCTCCGGTGTCCACGCGTTGACTG
CCGTGTGTGACTCCAGTCGGCGTCTCAACAGTCTCCGGTGTCCACGCGTTGACTGCCGTGTGTGACTCCAGTCGGCGTCTCAACAGTCTC
CGGTGTCCACGCGTTGACTGCCGTGTGTGACTCCAGTCGGCGTCTCAACAGTCTCCGGTGTCCACGCGTTGACTGCCGTGTGTGACTCCA
GTCGGCGTCTCAACAGTCTCCGGTGTCCATGCGTTGACTGCCATGTATGACTCCAGGTATTGAGTTCATCTTCAACTTCTCCCAACAATG
AACTGGAGTTTTCTGTGCATGTGTCTGGCATGTTTTCCTTTAGATCTAGTCCTAGGTGTTCGATATGCTATTGAGGACTGTGTATTTTTA
TTTCATTTGTCACCTGTGCGTGGTGCTTTAATCCTGTGCCCTAAACTCCCGCCTTGGCCATGGCGGTGTTTCTGTGGACTCGTGGGGTTT
CCGTGTGCACACGCGTGTCCTCTGTCTGACAGTGGCTTTGCTTCCCCTTGTCAGTCTGTGCCTCGGCTTCTCACTGCACTGGTGAGGTGA
GCCGGCGCTCGCTAATCTTATTCCCAGTCTCGGTGAACATGGGCTCAGTCTCTCCCGGCTCAGTGTTGGGTTTGCACTGGTGCACTTACA
GGCAGAAGAGCTTCCTCATTTGCTGAGGGCTTTTCCTGAATCCGTGTTGAATGTGGTCAGCTGCCTTTCCTGCACCTAGTGAGATGCTCA
TGAGGTCACTTCCTTACCGCATTACTGTAGTGAATTACGCTGACTTTCATATGCCAAGATGACCTGGCATTTCCAGGTAAGTCCCTGTGG
CCATGGTGCATTGGCCTTTTCTCTGCATGGCCAGATGAGATTTGCTCATACCGGGCTAAGGACCTCCTGTGTAGGAATGCTCTTGAGGGA
CACTGGGCTTGGATGTTCATTGTCTTGTCATGTGATGTGTCTGTCATGGTTTGATATTGCATTAAGTGGGCCTCCTGAAACAAGTTCTGC
CATAGTTTGTATAGGATTGGCATTATTTGTTTCATAGAGATGTGATGGGTGAGGCCATCTATGCCTGCCATTTTCTTTTTGCTTAGGTTT
TTCATTAAGAACTTGATTTTTAAAAATAGACATGAGGCCTGGCATGGTGGCTCACGCTTGTAATCCCAGCACTTTGGGAGGCCAACGTGG
ATGGATCACCTGAGGTCAGGAGTTTGAGACCAACCTAGTCAACATGGTGAAACCCCGTCTCCATTAAAAATATAAAAATTAGCAGGGTGT
GGTGGTGCATGCCTGTAATCCCAGCTACTCTGGAGGCTGAGGCAGGAGAATCACTTGAACTCAGGAGGTGGAGGTTGCAGTGAGCTGAGA
TCACACCACTGCACTCCAGCCTGGGCAACAGAGCGAGGCTCTGTCTCAAAAAAAAAGACATGAGGCTTTTGGATTTTCTGTTTCTTCCTT
TGTCATTTTTTTAAAGATAGGTTTGTCGCAGAATTTCATCTAAGTTATCAAAACAATTTACATAAATCATTCACAGTATCCTCTGTGCAG
TGATGTCCATTCTCATTCCTGCTCTGGGCCATTTGTGTTTTCTTTTCCCCCTGATCAGACTAGCTAAGAGTTTATCATTTTTACAGATAT
TTTCCCCAAAGAAACCTACTTTTGGGTCCATTGATTTTTTTTTTCTATTGTTTTCTTTTTCATTGACTTTTGCTCTTTTCTTATGAATTT
CCTTTCTTCTACCTATTTTGTGTTCAATTTGCTGTCCTTGTTTTAGGTTCTTTTGATAGAGGCTTAGATCATTGATGAAGAATATGAAAG
AATGGGATAATACAGTTAAAAACTTGGTCTACTTATGCCCATTAGAGAAAACATTCTTAAGCACGCATGGAATCTTTTAAAAATGGACGA
GGTACTAGGACCCAAAGCAAATGTCAGTAATTCGCAGATGATAATGTATAAATATATGATATGTAGGTAAATAATACAAATCACATTCTT
TGGCCAGAGTGCAATTGAGGAGGAAATCAGTAACAAAAAGACAATTAAATCCATTTGATTCTTTTGTTTTCGTTTTGTAGTAACTTGCAC
TTCCCTGGTGCCAGAGGCATGACACCTTTTTGTCTGCTCTTGGCCATTTGGGTGGCGTCTTTGGGAAGGGCCTACTTAATTCTTTTGCCT
ATTTAAAAAACTGGGTCTTGGAAATCTTGTCTTTTTTTTTGAGTCAGGATCTTTCTCGCACAGGCTTGGAGTGCAGTGGTGCGATCATAG
CTCACTGCAACCTCAAACTCCTGGGCTCAAGCGAGCCTCCCACCTCGGTCTTCTGAGTAGCTGGGACTACAGGCATGCATCACTATGCTC
TGCTAATTTAAAGAAAAGGTTTTTTTTATAGAGACTGGGTCTCGCTGTGTTGCCCAGGCTGGTCTCGGAGTCCTGGTCTCAAGTGATTCA
CCTGCCTCCACCTCGCGGAGTGCCAGGATTACAGGTGGCGGGAGCCGCCACACCCAGCCTGGTCTTAGCGTTATTCCCAGGTCTAGGTGT
GAGTCCTTCCTCAGATATGTGTTGTGAATAATTTCCGATCCTCTGGCTTGCTATTTTACTTTCTTAATGGTTATCTTTTGGAAAGCAAAG
GTTTCCAGTTTGATGAAATCTAATTTTTATTTTTTATTTTTCCGTTCTAGTGGTCTTTCTATTTTCTCATCAAATTGAGACTTTGGGGAA
ACTACACAGCAGCAAACCAGGATATATCCTCTTAAAAACAGCTCGAGCCGGCCGGGTGCGGTGGCTCATGCCTGGAATCCCAGCACTTTG
GGAGGTGGAGGTGGGCGGATCACGTGAGGTCAGGAGTTTGAGACCAGCCTGGCCAACATGGTGAAACCCCATCTCTACTAAAAATAAAAA
ATTAGCCAGGCATGGTGGCAGGCACCTGTAATCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATGGCTTGAACCTGGGAGGCAGAGGTTG

>44413_44413_6_LDLR-LRPAP1_LDLR_chr19_11200291_ENST00000558518_LRPAP1_chr4_3514763_ENST00000500728_length(amino acids)=221AA_BP=36
MADLNSQAKIQLQSKHNTPGGASSRFKHGNHARSWTRTRASSRLRHGNHAQSRTRASSRLRHGKGTTPRAGPEPLPGSDTGREPRSEPDP
SLFQAQTREGNHARSRTRASSRLRHGKGTTLGAGPEPLPGSDTGREPRSEPDPSLFQAQTREGNHAWSQTRASSRLRHRNILGAGPEQPP

--------------------------------------------------------------

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Fusion Gene PPI Analysis for LDLR-LRPAP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for LDLR-LRPAP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for LDLR-LRPAP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource