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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:LEMD3-KCNC2 (FusionGDB2 ID:44432)

Fusion Gene Summary for LEMD3-KCNC2

check button Fusion gene summary
Fusion gene informationFusion gene name: LEMD3-KCNC2
Fusion gene ID: 44432
HgeneTgene
Gene symbol

LEMD3

KCNC2

Gene ID

23592

3747

Gene nameLEM domain containing 3potassium voltage-gated channel subfamily C member 2
SynonymsMAN1KV3.2
Cytomap

12q14.3

12q21.1

Type of geneprotein-codingprotein-coding
Descriptioninner nuclear membrane protein Man1LEM domain-containing protein 3LEMD3/MKX fusionintegral inner nuclear membrane proteinpotassium voltage-gated channel subfamily C member 2potassium channel, voltage gated Shaw related subfamily C, member 2potassium voltage-gated channel, Shaw-related subfamily, member 2shaw-like potassium channelvoltage-gated potassium channel Kv3.2
Modification date2020031320200313
UniProtAcc

Q9Y2U8

.
Ensembl transtripts involved in fusion geneENST00000308330, ENST00000541171, 
ENST00000548243, ENST00000298972, 
ENST00000341669, ENST00000350228, 
ENST00000393288, ENST00000540018, 
ENST00000548513, ENST00000549446, 
ENST00000550433, 
Fusion gene scores* DoF score13 X 8 X 6=62415 X 5 X 6=450
# samples 1416
** MAII scorelog2(14/624*10)=-2.15611920191728
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(16/450*10)=-1.49185309632967
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: LEMD3 [Title/Abstract] AND KCNC2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointLEMD3(65612399)-KCNC2(75445097), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneLEMD3

GO:0030512

negative regulation of transforming growth factor beta receptor signaling pathway

15647271

HgeneLEMD3

GO:0030514

negative regulation of BMP signaling pathway

15647271

HgeneLEMD3

GO:0032926

negative regulation of activin receptor signaling pathway

15647271


check buttonFusion gene breakpoints across LEMD3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across KCNC2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-DX-AB2F-01ALEMD3chr12

65612399

-KCNC2chr12

75445097

-
ChimerDB4SARCTCGA-DX-AB2F-01ALEMD3chr12

65612399

+KCNC2chr12

75445097

-


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Fusion Gene ORF analysis for LEMD3-KCNC2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000308330ENST00000548243LEMD3chr12

65612399

+KCNC2chr12

75445097

-
In-frameENST00000308330ENST00000298972LEMD3chr12

65612399

+KCNC2chr12

75445097

-
In-frameENST00000308330ENST00000341669LEMD3chr12

65612399

+KCNC2chr12

75445097

-
In-frameENST00000308330ENST00000350228LEMD3chr12

65612399

+KCNC2chr12

75445097

-
In-frameENST00000308330ENST00000393288LEMD3chr12

65612399

+KCNC2chr12

75445097

-
In-frameENST00000308330ENST00000540018LEMD3chr12

65612399

+KCNC2chr12

75445097

-
In-frameENST00000308330ENST00000548513LEMD3chr12

65612399

+KCNC2chr12

75445097

-
In-frameENST00000308330ENST00000549446LEMD3chr12

65612399

+KCNC2chr12

75445097

-
In-frameENST00000308330ENST00000550433LEMD3chr12

65612399

+KCNC2chr12

75445097

-
intron-3CDSENST00000541171ENST00000298972LEMD3chr12

65612399

+KCNC2chr12

75445097

-
intron-3CDSENST00000541171ENST00000341669LEMD3chr12

65612399

+KCNC2chr12

75445097

-
intron-3CDSENST00000541171ENST00000350228LEMD3chr12

65612399

+KCNC2chr12

75445097

-
intron-3CDSENST00000541171ENST00000393288LEMD3chr12

65612399

+KCNC2chr12

75445097

-
intron-3CDSENST00000541171ENST00000540018LEMD3chr12

65612399

+KCNC2chr12

75445097

-
intron-3CDSENST00000541171ENST00000548513LEMD3chr12

65612399

+KCNC2chr12

75445097

-
intron-3CDSENST00000541171ENST00000549446LEMD3chr12

65612399

+KCNC2chr12

75445097

-
intron-3CDSENST00000541171ENST00000550433LEMD3chr12

65612399

+KCNC2chr12

75445097

-
intron-intronENST00000541171ENST00000548243LEMD3chr12

65612399

+KCNC2chr12

75445097

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000308330LEMD3chr1265612399+ENST00000550433KCNC2chr1275445097-39441721262923965
ENST00000308330LEMD3chr1265612399+ENST00000548513KCNC2chr1275445097-40391721262875949
ENST00000308330LEMD3chr1265612399+ENST00000549446KCNC2chr1275445097-59781721262950974
ENST00000308330LEMD3chr1265612399+ENST00000298972KCNC2chr1275445097-40001721262875949
ENST00000308330LEMD3chr1265612399+ENST00000341669KCNC2chr1275445097-39051721262923965
ENST00000308330LEMD3chr1265612399+ENST00000350228KCNC2chr1275445097-38341721262710894
ENST00000308330LEMD3chr1265612399+ENST00000540018KCNC2chr1275445097-29301721262785919
ENST00000308330LEMD3chr1265612399+ENST00000393288KCNC2chr1275445097-32711721262890954

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000308330ENST00000550433LEMD3chr1265612399+KCNC2chr1275445097-0.0003357840.9996642
ENST00000308330ENST00000548513LEMD3chr1265612399+KCNC2chr1275445097-0.0003314910.9996685
ENST00000308330ENST00000549446LEMD3chr1265612399+KCNC2chr1275445097-0.0001885910.9998115
ENST00000308330ENST00000298972LEMD3chr1265612399+KCNC2chr1275445097-0.0003449130.9996551
ENST00000308330ENST00000341669LEMD3chr1265612399+KCNC2chr1275445097-0.0003472920.99965274
ENST00000308330ENST00000350228LEMD3chr1265612399+KCNC2chr1275445097-0.0005135960.9994863
ENST00000308330ENST00000540018LEMD3chr1265612399+KCNC2chr1275445097-0.0010437650.9989562
ENST00000308330ENST00000393288LEMD3chr1265612399+KCNC2chr1275445097-0.0004699370.9995301

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Fusion Genomic Features for LEMD3-KCNC2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for LEMD3-KCNC2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:65612399/chr12:75445097)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LEMD3

Q9Y2U8

.
FUNCTION: Can function as a specific repressor of TGF-beta, activin, and BMP signaling through its interaction with the R-SMAD proteins. Antagonizes TGF-beta-induced cell proliferation arrest. {ECO:0000269|PubMed:15601644, ECO:0000269|PubMed:15647271}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLEMD3chr12:65612399chr12:75445097ENST00000308330+413155_158565912.0Compositional biasNote=Poly-Gly
HgeneLEMD3chr12:65612399chr12:75445097ENST00000308330+413265_268565912.0Compositional biasNote=Poly-Asp
HgeneLEMD3chr12:65612399chr12:75445097ENST00000308330+413312_315565912.0Compositional biasNote=Poly-Gly
HgeneLEMD3chr12:65612399chr12:75445097ENST00000308330+413322_325565912.0Compositional biasNote=Poly-Ala
HgeneLEMD3chr12:65612399chr12:75445097ENST00000308330+413337_340565912.0Compositional biasNote=Poly-Ala
HgeneLEMD3chr12:65612399chr12:75445097ENST00000308330+41365_70565912.0Compositional biasNote=Poly-Asn
HgeneLEMD3chr12:65612399chr12:75445097ENST00000308330+41372_87565912.0Compositional biasNote=Ala-rich
HgeneLEMD3chr12:65612399chr12:75445097ENST00000308330+41382_87565912.0Compositional biasNote=Poly-Ala
HgeneLEMD3chr12:65612399chr12:75445097ENST00000308330+4136_50565912.0DomainLEM
HgeneLEMD3chr12:65612399chr12:75445097ENST00000308330+413475_495565912.0TransmembraneHelical
TgeneKCNC2chr12:65612399chr12:75445097ENST0000029897216437_442229599.0RegionSelectivity filter
TgeneKCNC2chr12:65612399chr12:75445097ENST0000034166915437_442229630.0RegionSelectivity filter
TgeneKCNC2chr12:65612399chr12:75445097ENST0000035022815437_442229543.6666666666666RegionSelectivity filter
TgeneKCNC2chr12:65612399chr12:75445097ENST0000039328815437_442229619.0RegionSelectivity filter
TgeneKCNC2chr12:65612399chr12:75445097ENST0000054001814437_442229584.0RegionSelectivity filter
TgeneKCNC2chr12:65612399chr12:75445097ENST0000054851305437_442229477.0RegionSelectivity filter
TgeneKCNC2chr12:65612399chr12:75445097ENST0000054944615437_442229639.0RegionSelectivity filter
TgeneKCNC2chr12:65612399chr12:75445097ENST0000055043304437_442229630.0RegionSelectivity filter
TgeneKCNC2chr12:65612399chr12:75445097ENST0000029897216304_313229599.0Topological domainCytoplasmic
TgeneKCNC2chr12:65612399chr12:75445097ENST0000029897216369_381229599.0Topological domainCytoplasmic
TgeneKCNC2chr12:65612399chr12:75445097ENST0000029897216474_638229599.0Topological domainCytoplasmic
TgeneKCNC2chr12:65612399chr12:75445097ENST0000034166915304_313229630.0Topological domainCytoplasmic
TgeneKCNC2chr12:65612399chr12:75445097ENST0000034166915369_381229630.0Topological domainCytoplasmic
TgeneKCNC2chr12:65612399chr12:75445097ENST0000034166915474_638229630.0Topological domainCytoplasmic
TgeneKCNC2chr12:65612399chr12:75445097ENST0000035022815304_313229543.6666666666666Topological domainCytoplasmic
TgeneKCNC2chr12:65612399chr12:75445097ENST0000035022815369_381229543.6666666666666Topological domainCytoplasmic
TgeneKCNC2chr12:65612399chr12:75445097ENST0000035022815474_638229543.6666666666666Topological domainCytoplasmic
TgeneKCNC2chr12:65612399chr12:75445097ENST0000039328815304_313229619.0Topological domainCytoplasmic
TgeneKCNC2chr12:65612399chr12:75445097ENST0000039328815369_381229619.0Topological domainCytoplasmic
TgeneKCNC2chr12:65612399chr12:75445097ENST0000039328815474_638229619.0Topological domainCytoplasmic
TgeneKCNC2chr12:65612399chr12:75445097ENST0000054001814304_313229584.0Topological domainCytoplasmic
TgeneKCNC2chr12:65612399chr12:75445097ENST0000054001814369_381229584.0Topological domainCytoplasmic
TgeneKCNC2chr12:65612399chr12:75445097ENST0000054001814474_638229584.0Topological domainCytoplasmic
TgeneKCNC2chr12:65612399chr12:75445097ENST0000054851305304_313229477.0Topological domainCytoplasmic
TgeneKCNC2chr12:65612399chr12:75445097ENST0000054851305369_381229477.0Topological domainCytoplasmic
TgeneKCNC2chr12:65612399chr12:75445097ENST0000054851305474_638229477.0Topological domainCytoplasmic
TgeneKCNC2chr12:65612399chr12:75445097ENST0000054944615304_313229639.0Topological domainCytoplasmic
TgeneKCNC2chr12:65612399chr12:75445097ENST0000054944615369_381229639.0Topological domainCytoplasmic
TgeneKCNC2chr12:65612399chr12:75445097ENST0000054944615474_638229639.0Topological domainCytoplasmic
TgeneKCNC2chr12:65612399chr12:75445097ENST0000055043304304_313229630.0Topological domainCytoplasmic
TgeneKCNC2chr12:65612399chr12:75445097ENST0000055043304369_381229630.0Topological domainCytoplasmic
TgeneKCNC2chr12:65612399chr12:75445097ENST0000055043304474_638229630.0Topological domainCytoplasmic
TgeneKCNC2chr12:65612399chr12:75445097ENST0000029897216230_250229599.0TransmembraneHelical%3B Name%3DSegment S1
TgeneKCNC2chr12:65612399chr12:75445097ENST0000029897216284_303229599.0TransmembraneHelical%3B Name%3DSegment S2
TgeneKCNC2chr12:65612399chr12:75445097ENST0000029897216314_334229599.0TransmembraneHelical%3B Name%3DSegment S3
TgeneKCNC2chr12:65612399chr12:75445097ENST0000029897216346_368229599.0TransmembraneHelical%3B Voltage-sensor%3B Name%3DSegment S4
TgeneKCNC2chr12:65612399chr12:75445097ENST0000029897216382_402229599.0TransmembraneHelical%3B Name%3DSegment S5
TgeneKCNC2chr12:65612399chr12:75445097ENST0000029897216453_473229599.0TransmembraneHelical%3B Name%3DSegment S6
TgeneKCNC2chr12:65612399chr12:75445097ENST0000034166915230_250229630.0TransmembraneHelical%3B Name%3DSegment S1
TgeneKCNC2chr12:65612399chr12:75445097ENST0000034166915284_303229630.0TransmembraneHelical%3B Name%3DSegment S2
TgeneKCNC2chr12:65612399chr12:75445097ENST0000034166915314_334229630.0TransmembraneHelical%3B Name%3DSegment S3
TgeneKCNC2chr12:65612399chr12:75445097ENST0000034166915346_368229630.0TransmembraneHelical%3B Voltage-sensor%3B Name%3DSegment S4
TgeneKCNC2chr12:65612399chr12:75445097ENST0000034166915382_402229630.0TransmembraneHelical%3B Name%3DSegment S5
TgeneKCNC2chr12:65612399chr12:75445097ENST0000034166915453_473229630.0TransmembraneHelical%3B Name%3DSegment S6
TgeneKCNC2chr12:65612399chr12:75445097ENST0000035022815230_250229543.6666666666666TransmembraneHelical%3B Name%3DSegment S1
TgeneKCNC2chr12:65612399chr12:75445097ENST0000035022815284_303229543.6666666666666TransmembraneHelical%3B Name%3DSegment S2
TgeneKCNC2chr12:65612399chr12:75445097ENST0000035022815314_334229543.6666666666666TransmembraneHelical%3B Name%3DSegment S3
TgeneKCNC2chr12:65612399chr12:75445097ENST0000035022815346_368229543.6666666666666TransmembraneHelical%3B Voltage-sensor%3B Name%3DSegment S4
TgeneKCNC2chr12:65612399chr12:75445097ENST0000035022815382_402229543.6666666666666TransmembraneHelical%3B Name%3DSegment S5
TgeneKCNC2chr12:65612399chr12:75445097ENST0000035022815453_473229543.6666666666666TransmembraneHelical%3B Name%3DSegment S6
TgeneKCNC2chr12:65612399chr12:75445097ENST0000039328815230_250229619.0TransmembraneHelical%3B Name%3DSegment S1
TgeneKCNC2chr12:65612399chr12:75445097ENST0000039328815284_303229619.0TransmembraneHelical%3B Name%3DSegment S2
TgeneKCNC2chr12:65612399chr12:75445097ENST0000039328815314_334229619.0TransmembraneHelical%3B Name%3DSegment S3
TgeneKCNC2chr12:65612399chr12:75445097ENST0000039328815346_368229619.0TransmembraneHelical%3B Voltage-sensor%3B Name%3DSegment S4
TgeneKCNC2chr12:65612399chr12:75445097ENST0000039328815382_402229619.0TransmembraneHelical%3B Name%3DSegment S5
TgeneKCNC2chr12:65612399chr12:75445097ENST0000039328815453_473229619.0TransmembraneHelical%3B Name%3DSegment S6
TgeneKCNC2chr12:65612399chr12:75445097ENST0000054001814230_250229584.0TransmembraneHelical%3B Name%3DSegment S1
TgeneKCNC2chr12:65612399chr12:75445097ENST0000054001814284_303229584.0TransmembraneHelical%3B Name%3DSegment S2
TgeneKCNC2chr12:65612399chr12:75445097ENST0000054001814314_334229584.0TransmembraneHelical%3B Name%3DSegment S3
TgeneKCNC2chr12:65612399chr12:75445097ENST0000054001814346_368229584.0TransmembraneHelical%3B Voltage-sensor%3B Name%3DSegment S4
TgeneKCNC2chr12:65612399chr12:75445097ENST0000054001814382_402229584.0TransmembraneHelical%3B Name%3DSegment S5
TgeneKCNC2chr12:65612399chr12:75445097ENST0000054001814453_473229584.0TransmembraneHelical%3B Name%3DSegment S6
TgeneKCNC2chr12:65612399chr12:75445097ENST0000054851305230_250229477.0TransmembraneHelical%3B Name%3DSegment S1
TgeneKCNC2chr12:65612399chr12:75445097ENST0000054851305284_303229477.0TransmembraneHelical%3B Name%3DSegment S2
TgeneKCNC2chr12:65612399chr12:75445097ENST0000054851305314_334229477.0TransmembraneHelical%3B Name%3DSegment S3
TgeneKCNC2chr12:65612399chr12:75445097ENST0000054851305346_368229477.0TransmembraneHelical%3B Voltage-sensor%3B Name%3DSegment S4
TgeneKCNC2chr12:65612399chr12:75445097ENST0000054851305382_402229477.0TransmembraneHelical%3B Name%3DSegment S5
TgeneKCNC2chr12:65612399chr12:75445097ENST0000054851305453_473229477.0TransmembraneHelical%3B Name%3DSegment S6
TgeneKCNC2chr12:65612399chr12:75445097ENST0000054944615230_250229639.0TransmembraneHelical%3B Name%3DSegment S1
TgeneKCNC2chr12:65612399chr12:75445097ENST0000054944615284_303229639.0TransmembraneHelical%3B Name%3DSegment S2
TgeneKCNC2chr12:65612399chr12:75445097ENST0000054944615314_334229639.0TransmembraneHelical%3B Name%3DSegment S3
TgeneKCNC2chr12:65612399chr12:75445097ENST0000054944615346_368229639.0TransmembraneHelical%3B Voltage-sensor%3B Name%3DSegment S4
TgeneKCNC2chr12:65612399chr12:75445097ENST0000054944615382_402229639.0TransmembraneHelical%3B Name%3DSegment S5
TgeneKCNC2chr12:65612399chr12:75445097ENST0000054944615453_473229639.0TransmembraneHelical%3B Name%3DSegment S6
TgeneKCNC2chr12:65612399chr12:75445097ENST0000055043304230_250229630.0TransmembraneHelical%3B Name%3DSegment S1
TgeneKCNC2chr12:65612399chr12:75445097ENST0000055043304284_303229630.0TransmembraneHelical%3B Name%3DSegment S2
TgeneKCNC2chr12:65612399chr12:75445097ENST0000055043304314_334229630.0TransmembraneHelical%3B Name%3DSegment S3
TgeneKCNC2chr12:65612399chr12:75445097ENST0000055043304346_368229630.0TransmembraneHelical%3B Voltage-sensor%3B Name%3DSegment S4
TgeneKCNC2chr12:65612399chr12:75445097ENST0000055043304382_402229630.0TransmembraneHelical%3B Name%3DSegment S5
TgeneKCNC2chr12:65612399chr12:75445097ENST0000055043304453_473229630.0TransmembraneHelical%3B Name%3DSegment S6

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLEMD3chr12:65612399chr12:75445097ENST00000308330+413635_640565912.0Compositional biasNote=Poly-Leu
HgeneLEMD3chr12:65612399chr12:75445097ENST00000308330+413659_662565912.0Compositional biasNote=Poly-Glu
HgeneLEMD3chr12:65612399chr12:75445097ENST00000308330+413707_726565912.0DNA binding.
HgeneLEMD3chr12:65612399chr12:75445097ENST00000308330+413628_648565912.0TransmembraneHelical
TgeneKCNC2chr12:65612399chr12:75445097ENST000002989721656_99229599.0Compositional biasNote=Gly/Pro-rich (insert)
TgeneKCNC2chr12:65612399chr12:75445097ENST000003416691556_99229630.0Compositional biasNote=Gly/Pro-rich (insert)
TgeneKCNC2chr12:65612399chr12:75445097ENST000003502281556_99229543.6666666666666Compositional biasNote=Gly/Pro-rich (insert)
TgeneKCNC2chr12:65612399chr12:75445097ENST000003932881556_99229619.0Compositional biasNote=Gly/Pro-rich (insert)
TgeneKCNC2chr12:65612399chr12:75445097ENST000005400181456_99229584.0Compositional biasNote=Gly/Pro-rich (insert)
TgeneKCNC2chr12:65612399chr12:75445097ENST000005485130556_99229477.0Compositional biasNote=Gly/Pro-rich (insert)
TgeneKCNC2chr12:65612399chr12:75445097ENST000005494461556_99229639.0Compositional biasNote=Gly/Pro-rich (insert)
TgeneKCNC2chr12:65612399chr12:75445097ENST000005504330456_99229630.0Compositional biasNote=Gly/Pro-rich (insert)
TgeneKCNC2chr12:65612399chr12:75445097ENST00000298972161_229229599.0Topological domainCytoplasmic
TgeneKCNC2chr12:65612399chr12:75445097ENST00000341669151_229229630.0Topological domainCytoplasmic
TgeneKCNC2chr12:65612399chr12:75445097ENST00000350228151_229229543.6666666666666Topological domainCytoplasmic
TgeneKCNC2chr12:65612399chr12:75445097ENST00000393288151_229229619.0Topological domainCytoplasmic
TgeneKCNC2chr12:65612399chr12:75445097ENST00000540018141_229229584.0Topological domainCytoplasmic
TgeneKCNC2chr12:65612399chr12:75445097ENST00000548513051_229229477.0Topological domainCytoplasmic
TgeneKCNC2chr12:65612399chr12:75445097ENST00000549446151_229229639.0Topological domainCytoplasmic
TgeneKCNC2chr12:65612399chr12:75445097ENST00000550433041_229229630.0Topological domainCytoplasmic


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Fusion Gene Sequence for LEMD3-KCNC2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>44432_44432_1_LEMD3-KCNC2_LEMD3_chr12_65612399_ENST00000308330_KCNC2_chr12_75445097_ENST00000298972_length(transcript)=4000nt_BP=1721nt
AGCTTGTAAAACACCCTGGAGAGAAAATGGCGGCGGCAGCAGCTTCGGCGCCTCAGCAGCTCTCGGATGAGGAGCTTTTCTCTCAGCTCC
GCCGTTACGGCCTGTCTCCCGGACCAGTGACGGAGAGCACCCGCCCGGTCTACCTCAAGAAGCTGAAGAAGCTTCGAGAGGAAGAGCAGC
AACAGCACCGGTCAGGGGGCCGCGGCAACAAGACGCGGAACAGTAATAACAATAACACGGCAGCCGCCACGGTCGCAGCCGCGGGACCAG
CGGCGGCGGCGGCCGCGGGGATGGGGGTCCGGCCGGTCTCGGGCGACCTCTCCTACTTACGGACTCCTGGGGGCCTGTGCCGAATCTCGG
CCTCTGGCCCAGAGAGCCTCCTGGGAGGGCCCGGGGGCGCCTCCGCCGCCCCCGCGGCTGGCAGCAAAGTGCTGCTGGGCTTCAGCTCGG
ACGAGTCGGACGTGGAGGCCAGTCCCCGGGACCAGGCCGGCGGCGGCGGGAGGAAAGACCGGGCTTCGCTCCAGTACCGCGGGCTCAAAG
CGCCGCCGGCGCCCCTGGCCGCCAGCGAGGTGACTAACAGCAACTCTGCAGAGCGAAGGAAGCCCCACTCGTGGTGGGGGGCCAGGAGGC
CGGCGGGCCCCGAGCTGCAGACCCCGCCGGGGAAAGATGGAGCAGTGGAGGACGAGGAAGGGGAGGGAGAGGACGGTGAGGAGAGGGACC
CGGAGACCGAGGAGCCGCTCTGGGCGAGCCGGACCGTGAATGGCAGCCGGCTTGTCCCCTACAGCTGCCGGGAAAACTATTCGGACTCAG
AGGAAGAGGACGACGACGACGTGGCCTCCAGCAGACAGGTATTAAAGGACGACTCCCTTTCCCGGCATCGGCCCAGACGAACCCATAGTA
AGCCTCTCCCCCCGCTGACTGCTAAATCGGCCGGCGGCAGGCTGGAGACTTCAGTTCAGGGAGGGGGAGGACTCGCGATGAATGACAGGG
CGGCGGCTGCCGGGAGTCTAGACAGGAGCCGAAACCTCGAAGAGGCGGCGGCCGCGGAGCAGGGAGGAGGGTGTGATCAAGTGGACTCCA
GCCCCGTTCCTAGATACCGTGTTAACGCTAAGAAACTGACCCCTCTCCTGCCCCCGCCACTTACTGACATGGACTCAACCTTGGATTCGT
CAACAGGCTCCCTTCTGAAAACCAATAATCATATTGGCGGTGGGGCCTTCAGTGTGGACTCCCCCAGGATTTATTCTAACAGTCTCCCTC
CCAGTGCGGCGGTGGCCGCCTCTAGTTCACTCAGGATCAATCACGCCAATCATACGGGCTCCAATCATACCTACCTGAAAAACACATACA
ACAAACCGAAGCTTTCCGAACCCGAAGAGGAACTTCTCCAGCAATTTAAACGGGAGGAGGTGTCCCCAACAGGGAGTTTCAGTGCCCACT
ACTTGTCGATGTTTCTCTTAACTGCTGCCTGCTTATTTTTCCTAATACTGGGACTGACTTACCTAGGAATGAGAGGGACAGGAGTATCTG
AGGATGGAGAACTCAGCATAGAAAACCCCTTTGGTGAAACATTTGGAAAAATACAAGAAAGTGAAAAAACTCTTATGATGAACACATTAT
ATAAGCTTCATGATCGATTGGCACAGCTTGCAGGAGATCATGAATGTGGCAGTTCTAGTCAAAGAACGCTTTCTGTTCAAGAGGCAGCTG
CGTATTTAAAATTTATTGCTTTTGCTTCTTTATTCTTCATCCTGGTTTCAATTACAACTTTTTGCCTGGAAACACATGAAGCTTTCAATA
TTGTTAAAAACAAGACAGAACCAGTCATCAATGGCACAAGTGTTGTTCTACAGTATGAAATTGAAACGGATCCTGCCTTGACGTATGTAG
AAGGAGTGTGTGTGGTGTGGTTTACTTTTGAATTTTTAGTCCGTATTGTTTTTTCACCCAATAAACTTGAATTCATCAAAAATCTCTTGA
ATATCATTGACTTTGTGGCCATCCTACCTTTCTACTTAGAGGTGGGACTCAGTGGGCTGTCATCCAAAGCTGCTAAAGATGTGCTTGGCT
TCCTCAGGGTGGTAAGGTTTGTGAGGATCCTGAGAATTTTCAAGCTCACCCGCCATTTTGTAGGTCTGAGGGTGCTTGGACATACTCTTC
GAGCTAGTACTAATGAATTTTTGCTGCTGATAATTTTCCTGGCTCTAGGAGTTTTGATATTTGCTACCATGATCTACTATGCCGAGAGAG
TGGGAGCTCAACCTAACGACCCTTCAGCTAGTGAGCACACACAGTTCAAAAACATTCCCATTGGGTTCTGGTGGGCTGTAGTGACCATGA
CTACCCTGGGTTATGGGGATATGTACCCCCAAACATGGTCAGGCATGCTGGTGGGAGCCCTGTGTGCTCTGGCTGGAGTGCTGACAATAG
CCATGCCAGTGCCTGTCATTGTCAATAATTTTGGAATGTACTACTCCTTGGCAATGGCAAAGCAGAAACTTCCAAGGAAAAGAAAGAAGC
ACATCCCTCCTGCTCCTCAGGCAAGCTCACCTACTTTTTGCAAGACAGAATTAAATATGGCCTGCAATAGTACACAGAGTGACACATGTC
TGGGCAAAGACAATCGACTTCTGGAACATAACAGATCAGTGTTATCAGGTGACGACAGTACAGGAAGTGAGCCGCCACTATCACCCCCAG
AAAGGCTCCCCATCAGACGCTCTAGTACCAGAGACAAAAACAGAAGAGGGGAAACATGTTTCCTACTGACGACAGGTGATTACACGTGTG
CTTCTGATGGAGGGATCAGGAAAGATAACTGCAAAGAGGTTGTCATTACTGGTTACACGCAAGCCGAGGCCAGATCTCTTACTTAATGAC
TTGGGGAAGGCACAAAACATGAGAGAAAGTGTTGTACAGAATTTATCATGGATTATTGACTGCTGAGAAAGGGACAGTGGAATTTAGCCA
TACCAAGGACTATACTGGAAACAGACTTCTGCTGCTGAATGTGCCCTGATGTGACCAGGTTGCACTTGGAAGAGATCCTCGCGTCTTCAT
GAGGCACTTAAAGCTTATAAAAGAACTGCGGCTGGAACTCATCTGGTGCTCCCCATGAGAGTGCTCTGCTTGTAGACTGGCCAGTGTCCA
TGAAACAACTGTAAATACCAACATGTGTGCATGGGTCAACAGTCTTGGCCATTTCTCATCAAAAGAAGCCAAATTCATGATCAACATCTC
TGAAGTTTCAAGTAAGGCCCACACTTCTTTGAATTACTCTTCATGGGCCCACATTAGGTTGTGCTGTGAATTACTTAAGGCAGTGATACT
GATGTAGTATAGTTTTGTCTTAATTTCCCTTATTTCTACTTCTTTGGTTGAATCTATGAACTTGATTGTATAATTTTCTTATAAATTACT
GATGTAATCAGCTTGTCAATTATGTTGTGAAATTGTTAGTATTCATTTATCAAAAATGACCTATGTTTAGTCACATATTTGTTTAGTTCT
GGGAAATTGTTATAGCTTAAATGGAACTCACCAACATTATTCATAGTTTAAGTCTTTTATCATTATTACCTCAATTATAAATATTACAAA
AACATAATTCTGGCAATGAGAGTATTTTTTTATTCAATGATCAAGGAGCAATGTCAGTATATAGTAGAATATCAATTAAATTATATCCTA
AAATGTATATTTTGCATAAAAGAGATATTCTTTAATCAATTACTTTTTTGTGAGTTTTGTGGCAAATGAAGCTTGTACGTGTCTTTAAAA
CTGTTGTAGATGAAACTGTATAAGATTTTTACATCTTGCTTAATCAATATTTTCAGAGTCTATTAGTTCCCCTGGGATTCTGAATATAAC
ATATAGCCTATTATAAATCCCTGTATCGTGGACCTTTTGTGAACATTTCAAGGCGCATGCACAACCTTGATGATAACCAGTGGAAATGTA

>44432_44432_1_LEMD3-KCNC2_LEMD3_chr12_65612399_ENST00000308330_KCNC2_chr12_75445097_ENST00000298972_length(amino acids)=949AA_BP=563
MAAAAASAPQQLSDEELFSQLRRYGLSPGPVTESTRPVYLKKLKKLREEEQQQHRSGGRGNKTRNSNNNNTAAATVAAAGPAAAAAAGMG
VRPVSGDLSYLRTPGGLCRISASGPESLLGGPGGASAAPAAGSKVLLGFSSDESDVEASPRDQAGGGGRKDRASLQYRGLKAPPAPLAAS
EVTNSNSAERRKPHSWWGARRPAGPELQTPPGKDGAVEDEEGEGEDGEERDPETEEPLWASRTVNGSRLVPYSCRENYSDSEEEDDDDVA
SSRQVLKDDSLSRHRPRRTHSKPLPPLTAKSAGGRLETSVQGGGGLAMNDRAAAAGSLDRSRNLEEAAAAEQGGGCDQVDSSPVPRYRVN
AKKLTPLLPPPLTDMDSTLDSSTGSLLKTNNHIGGGAFSVDSPRIYSNSLPPSAAVAASSSLRINHANHTGSNHTYLKNTYNKPKLSEPE
EELLQQFKREEVSPTGSFSAHYLSMFLLTAACLFFLILGLTYLGMRGTGVSEDGELSIENPFGETFGKIQESEKTLMMNTLYKLHDRLAQ
LAGDHECGSSSQRTLSVQEAAAYLKFIAFASLFFILVSITTFCLETHEAFNIVKNKTEPVINGTSVVLQYEIETDPALTYVEGVCVVWFT
FEFLVRIVFSPNKLEFIKNLLNIIDFVAILPFYLEVGLSGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLL
LIIFLALGVLIFATMIYYAERVGAQPNDPSASEHTQFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTIAMPVPVIVN
NFGMYYSLAMAKQKLPRKRKKHIPPAPQASSPTFCKTELNMACNSTQSDTCLGKDNRLLEHNRSVLSGDDSTGSEPPLSPPERLPIRRSS

--------------------------------------------------------------
>44432_44432_2_LEMD3-KCNC2_LEMD3_chr12_65612399_ENST00000308330_KCNC2_chr12_75445097_ENST00000341669_length(transcript)=3905nt_BP=1721nt
AGCTTGTAAAACACCCTGGAGAGAAAATGGCGGCGGCAGCAGCTTCGGCGCCTCAGCAGCTCTCGGATGAGGAGCTTTTCTCTCAGCTCC
GCCGTTACGGCCTGTCTCCCGGACCAGTGACGGAGAGCACCCGCCCGGTCTACCTCAAGAAGCTGAAGAAGCTTCGAGAGGAAGAGCAGC
AACAGCACCGGTCAGGGGGCCGCGGCAACAAGACGCGGAACAGTAATAACAATAACACGGCAGCCGCCACGGTCGCAGCCGCGGGACCAG
CGGCGGCGGCGGCCGCGGGGATGGGGGTCCGGCCGGTCTCGGGCGACCTCTCCTACTTACGGACTCCTGGGGGCCTGTGCCGAATCTCGG
CCTCTGGCCCAGAGAGCCTCCTGGGAGGGCCCGGGGGCGCCTCCGCCGCCCCCGCGGCTGGCAGCAAAGTGCTGCTGGGCTTCAGCTCGG
ACGAGTCGGACGTGGAGGCCAGTCCCCGGGACCAGGCCGGCGGCGGCGGGAGGAAAGACCGGGCTTCGCTCCAGTACCGCGGGCTCAAAG
CGCCGCCGGCGCCCCTGGCCGCCAGCGAGGTGACTAACAGCAACTCTGCAGAGCGAAGGAAGCCCCACTCGTGGTGGGGGGCCAGGAGGC
CGGCGGGCCCCGAGCTGCAGACCCCGCCGGGGAAAGATGGAGCAGTGGAGGACGAGGAAGGGGAGGGAGAGGACGGTGAGGAGAGGGACC
CGGAGACCGAGGAGCCGCTCTGGGCGAGCCGGACCGTGAATGGCAGCCGGCTTGTCCCCTACAGCTGCCGGGAAAACTATTCGGACTCAG
AGGAAGAGGACGACGACGACGTGGCCTCCAGCAGACAGGTATTAAAGGACGACTCCCTTTCCCGGCATCGGCCCAGACGAACCCATAGTA
AGCCTCTCCCCCCGCTGACTGCTAAATCGGCCGGCGGCAGGCTGGAGACTTCAGTTCAGGGAGGGGGAGGACTCGCGATGAATGACAGGG
CGGCGGCTGCCGGGAGTCTAGACAGGAGCCGAAACCTCGAAGAGGCGGCGGCCGCGGAGCAGGGAGGAGGGTGTGATCAAGTGGACTCCA
GCCCCGTTCCTAGATACCGTGTTAACGCTAAGAAACTGACCCCTCTCCTGCCCCCGCCACTTACTGACATGGACTCAACCTTGGATTCGT
CAACAGGCTCCCTTCTGAAAACCAATAATCATATTGGCGGTGGGGCCTTCAGTGTGGACTCCCCCAGGATTTATTCTAACAGTCTCCCTC
CCAGTGCGGCGGTGGCCGCCTCTAGTTCACTCAGGATCAATCACGCCAATCATACGGGCTCCAATCATACCTACCTGAAAAACACATACA
ACAAACCGAAGCTTTCCGAACCCGAAGAGGAACTTCTCCAGCAATTTAAACGGGAGGAGGTGTCCCCAACAGGGAGTTTCAGTGCCCACT
ACTTGTCGATGTTTCTCTTAACTGCTGCCTGCTTATTTTTCCTAATACTGGGACTGACTTACCTAGGAATGAGAGGGACAGGAGTATCTG
AGGATGGAGAACTCAGCATAGAAAACCCCTTTGGTGAAACATTTGGAAAAATACAAGAAAGTGAAAAAACTCTTATGATGAACACATTAT
ATAAGCTTCATGATCGATTGGCACAGCTTGCAGGAGATCATGAATGTGGCAGTTCTAGTCAAAGAACGCTTTCTGTTCAAGAGGCAGCTG
CGTATTTAAAATTTATTGCTTTTGCTTCTTTATTCTTCATCCTGGTTTCAATTACAACTTTTTGCCTGGAAACACATGAAGCTTTCAATA
TTGTTAAAAACAAGACAGAACCAGTCATCAATGGCACAAGTGTTGTTCTACAGTATGAAATTGAAACGGATCCTGCCTTGACGTATGTAG
AAGGAGTGTGTGTGGTGTGGTTTACTTTTGAATTTTTAGTCCGTATTGTTTTTTCACCCAATAAACTTGAATTCATCAAAAATCTCTTGA
ATATCATTGACTTTGTGGCCATCCTACCTTTCTACTTAGAGGTGGGACTCAGTGGGCTGTCATCCAAAGCTGCTAAAGATGTGCTTGGCT
TCCTCAGGGTGGTAAGGTTTGTGAGGATCCTGAGAATTTTCAAGCTCACCCGCCATTTTGTAGGTCTGAGGGTGCTTGGACATACTCTTC
GAGCTAGTACTAATGAATTTTTGCTGCTGATAATTTTCCTGGCTCTAGGAGTTTTGATATTTGCTACCATGATCTACTATGCCGAGAGAG
TGGGAGCTCAACCTAACGACCCTTCAGCTAGTGAGCACACACAGTTCAAAAACATTCCCATTGGGTTCTGGTGGGCTGTAGTGACCATGA
CTACCCTGGGTTATGGGGATATGTACCCCCAAACATGGTCAGGCATGCTGGTGGGAGCCCTGTGTGCTCTGGCTGGAGTGCTGACAATAG
CCATGCCAGTGCCTGTCATTGTCAATAATTTTGGAATGTACTACTCCTTGGCAATGGCAAAGCAGAAACTTCCAAGGAAAAGAAAGAAGC
ACATCCCTCCTGCTCCTCAGGCAAGCTCACCTACTTTTTGCAAGACAGAATTAAATATGGCCTGCAATAGTACACAGAGTGACACATGTC
TGGGCAAAGACAATCGACTTCTGGAACATAACAGATCAGTGTTATCAGGTGACGACAGTACAGGAAGTGAGCCGCCACTATCACCCCCAG
AAAGGCTCCCCATCAGACGCTCTAGTACCAGAGACAAAAACAGAAGAGGGGAAACATGTTTCCTACTGACGACAGGTGATTACACGTGTG
CTTCTGATGGAGGGATCAGGAAAGTGTTGTACAGAATTTATCATGGATTATTGACTGCTGAGAAAGGGACAGTGGAATTTAGCCATACCA
AGGACTATACTGGAAACAGACTTCTGCTGCTGAATGTGCCCTGATGTGACCAGGTTGCACTTGGAAGAGATCCTCGCGTCTTCATGAGGC
ACTTAAAGCTTATAAAAGAACTGCGGCTGGAACTCATCTGGTGCTCCCCATGAGAGTGCTCTGCTTGTAGACTGGCCAGTGTCCATGAAA
CAACTGTAAATACCAACATGTGTGCATGGGTCAACAGTCTTGGCCATTTCTCATCAAAAGAAGCCAAATTCATGATCAACATCTCTGAAG
TTTCAAGTAAGGCCCACACTTCTTTGAATTACTCTTCATGGGCCCACATTAGGTTGTGCTGTGAATTACTTAAGGCAGTGATACTGATGT
AGTATAGTTTTGTCTTAATTTCCCTTATTTCTACTTCTTTGGTTGAATCTATGAACTTGATTGTATAATTTTCTTATAAATTACTGATGT
AATCAGCTTGTCAATTATGTTGTGAAATTGTTAGTATTCATTTATCAAAAATGACCTATGTTTAGTCACATATTTGTTTAGTTCTGGGAA
ATTGTTATAGCTTAAATGGAACTCACCAACATTATTCATAGTTTAAGTCTTTTATCATTATTACCTCAATTATAAATATTACAAAAACAT
AATTCTGGCAATGAGAGTATTTTTTTATTCAATGATCAAGGAGCAATGTCAGTATATAGTAGAATATCAATTAAATTATATCCTAAAATG
TATATTTTGCATAAAAGAGATATTCTTTAATCAATTACTTTTTTGTGAGTTTTGTGGCAAATGAAGCTTGTACGTGTCTTTAAAACTGTT
GTAGATGAAACTGTATAAGATTTTTACATCTTGCTTAATCAATATTTTCAGAGTCTATTAGTTCCCCTGGGATTCTGAATATAACATATA
GCCTATTATAAATCCCTGTATCGTGGACCTTTTGTGAACATTTCAAGGCGCATGCACAACCTTGATGATAACCAGTGGAAATGTAACTAA

>44432_44432_2_LEMD3-KCNC2_LEMD3_chr12_65612399_ENST00000308330_KCNC2_chr12_75445097_ENST00000341669_length(amino acids)=965AA_BP=563
MAAAAASAPQQLSDEELFSQLRRYGLSPGPVTESTRPVYLKKLKKLREEEQQQHRSGGRGNKTRNSNNNNTAAATVAAAGPAAAAAAGMG
VRPVSGDLSYLRTPGGLCRISASGPESLLGGPGGASAAPAAGSKVLLGFSSDESDVEASPRDQAGGGGRKDRASLQYRGLKAPPAPLAAS
EVTNSNSAERRKPHSWWGARRPAGPELQTPPGKDGAVEDEEGEGEDGEERDPETEEPLWASRTVNGSRLVPYSCRENYSDSEEEDDDDVA
SSRQVLKDDSLSRHRPRRTHSKPLPPLTAKSAGGRLETSVQGGGGLAMNDRAAAAGSLDRSRNLEEAAAAEQGGGCDQVDSSPVPRYRVN
AKKLTPLLPPPLTDMDSTLDSSTGSLLKTNNHIGGGAFSVDSPRIYSNSLPPSAAVAASSSLRINHANHTGSNHTYLKNTYNKPKLSEPE
EELLQQFKREEVSPTGSFSAHYLSMFLLTAACLFFLILGLTYLGMRGTGVSEDGELSIENPFGETFGKIQESEKTLMMNTLYKLHDRLAQ
LAGDHECGSSSQRTLSVQEAAAYLKFIAFASLFFILVSITTFCLETHEAFNIVKNKTEPVINGTSVVLQYEIETDPALTYVEGVCVVWFT
FEFLVRIVFSPNKLEFIKNLLNIIDFVAILPFYLEVGLSGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLL
LIIFLALGVLIFATMIYYAERVGAQPNDPSASEHTQFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTIAMPVPVIVN
NFGMYYSLAMAKQKLPRKRKKHIPPAPQASSPTFCKTELNMACNSTQSDTCLGKDNRLLEHNRSVLSGDDSTGSEPPLSPPERLPIRRSS

--------------------------------------------------------------
>44432_44432_3_LEMD3-KCNC2_LEMD3_chr12_65612399_ENST00000308330_KCNC2_chr12_75445097_ENST00000350228_length(transcript)=3834nt_BP=1721nt
AGCTTGTAAAACACCCTGGAGAGAAAATGGCGGCGGCAGCAGCTTCGGCGCCTCAGCAGCTCTCGGATGAGGAGCTTTTCTCTCAGCTCC
GCCGTTACGGCCTGTCTCCCGGACCAGTGACGGAGAGCACCCGCCCGGTCTACCTCAAGAAGCTGAAGAAGCTTCGAGAGGAAGAGCAGC
AACAGCACCGGTCAGGGGGCCGCGGCAACAAGACGCGGAACAGTAATAACAATAACACGGCAGCCGCCACGGTCGCAGCCGCGGGACCAG
CGGCGGCGGCGGCCGCGGGGATGGGGGTCCGGCCGGTCTCGGGCGACCTCTCCTACTTACGGACTCCTGGGGGCCTGTGCCGAATCTCGG
CCTCTGGCCCAGAGAGCCTCCTGGGAGGGCCCGGGGGCGCCTCCGCCGCCCCCGCGGCTGGCAGCAAAGTGCTGCTGGGCTTCAGCTCGG
ACGAGTCGGACGTGGAGGCCAGTCCCCGGGACCAGGCCGGCGGCGGCGGGAGGAAAGACCGGGCTTCGCTCCAGTACCGCGGGCTCAAAG
CGCCGCCGGCGCCCCTGGCCGCCAGCGAGGTGACTAACAGCAACTCTGCAGAGCGAAGGAAGCCCCACTCGTGGTGGGGGGCCAGGAGGC
CGGCGGGCCCCGAGCTGCAGACCCCGCCGGGGAAAGATGGAGCAGTGGAGGACGAGGAAGGGGAGGGAGAGGACGGTGAGGAGAGGGACC
CGGAGACCGAGGAGCCGCTCTGGGCGAGCCGGACCGTGAATGGCAGCCGGCTTGTCCCCTACAGCTGCCGGGAAAACTATTCGGACTCAG
AGGAAGAGGACGACGACGACGTGGCCTCCAGCAGACAGGTATTAAAGGACGACTCCCTTTCCCGGCATCGGCCCAGACGAACCCATAGTA
AGCCTCTCCCCCCGCTGACTGCTAAATCGGCCGGCGGCAGGCTGGAGACTTCAGTTCAGGGAGGGGGAGGACTCGCGATGAATGACAGGG
CGGCGGCTGCCGGGAGTCTAGACAGGAGCCGAAACCTCGAAGAGGCGGCGGCCGCGGAGCAGGGAGGAGGGTGTGATCAAGTGGACTCCA
GCCCCGTTCCTAGATACCGTGTTAACGCTAAGAAACTGACCCCTCTCCTGCCCCCGCCACTTACTGACATGGACTCAACCTTGGATTCGT
CAACAGGCTCCCTTCTGAAAACCAATAATCATATTGGCGGTGGGGCCTTCAGTGTGGACTCCCCCAGGATTTATTCTAACAGTCTCCCTC
CCAGTGCGGCGGTGGCCGCCTCTAGTTCACTCAGGATCAATCACGCCAATCATACGGGCTCCAATCATACCTACCTGAAAAACACATACA
ACAAACCGAAGCTTTCCGAACCCGAAGAGGAACTTCTCCAGCAATTTAAACGGGAGGAGGTGTCCCCAACAGGGAGTTTCAGTGCCCACT
ACTTGTCGATGTTTCTCTTAACTGCTGCCTGCTTATTTTTCCTAATACTGGGACTGACTTACCTAGGAATGAGAGGGACAGGAGTATCTG
AGGATGGAGAACTCAGCATAGAAAACCCCTTTGGTGAAACATTTGGAAAAATACAAGAAAGTGAAAAAACTCTTATGATGAACACATTAT
ATAAGCTTCATGATCGATTGGCACAGCTTGCAGGAGATCATGAATGTGGCAGTTCTAGTCAAAGAACGCTTTCTGTTCAAGAGGCAGCTG
CGTATTTAAAATTTATTGCTTTTGCTTCTTTATTCTTCATCCTGGTTTCAATTACAACTTTTTGCCTGGAAACACATGAAGCTTTCAATA
TTGTTAAAAACAAGACAGAACCAGTCATCAATGGCACAAGTGTTGTTCTACAGTATGAAATTGAAACGGATCCTGCCTTGACGTATGTAG
AAGGAGTGTGTGTGGTGTGGTTTACTTTTGAATTTTTAGTCCGTATTGTTTTTTCACCCAATAAACTTGAATTCATCAAAAATCTCTTGA
ATATCATTGACTTTGTGGCCATCCTACCTTTCTACTTAGAGGTGGGACTCAGTGGGCTGTCATCCAAAGCTGCTAAAGATGTGCTTGGCT
TCCTCAGGGTGGTAAGGTTTGTGAGGATCCTGAGAATTTTCAAGCTCACCCGCCATTTTGTAGGTCTGAGGGTGCTTGGACATACTCTTC
GAGCTAGTACTAATGAATTTTTGCTGCTGATAATTTTCCTGGCTCTAGGAGTTTTGATATTTGCTACCATGATCTACTATGCCGAGAGAG
TGGGAGCTCAACCTAACGACCCTTCAGCTAGTGAGCACACACAGTTCAAAAACATTCCCATTGGGTTCTGGTGGGCTGTAGTGACCATGA
CTACCCTGGGTTATGGGGATATGTACCCCCAAACATGGTCAGGCATGCTGGTGGGAGCCCTGTGTGCTCTGGCTGGAGTGCTGACAATAG
CCATGCCAGTGCCTGTCATTGTCAATAATTTTGGAATGTACTACTCCTTGGCAATGGCAAAGCAGAAACTTCCAAGGAAAAGAAAGAAGC
ACATCCCTCCTGCTCCTCAGGCAAGCTCACCTACTTTTTGCAAGACAGAATTAAATATGGCCTGCAATAGTACACAGAGTGACACATGTC
TGGGCAAAGACAATCGACTTCTGGAACATAACAGATCAGATAACTGCAAAGAGGTTGTCATTACTGGTTACACGCAAGCCGAGGCCAGAT
CTCTTACTTAATGACTTGGGGAAGGCACAAAACATGAGAGAAAGTGTTGTACAGAATTTATCATGGATTATTGACTGCTGAGAAAGGGAC
AGTGGAATTTAGCCATACCAAGGACTATACTGGAAACAGACTTCTGCTGCTGAATGTGCCCTGATGTGACCAGGTTGCACTTGGAAGAGA
TCCTCGCGTCTTCATGAGGCACTTAAAGCTTATAAAAGAACTGCGGCTGGAACTCATCTGGTGCTCCCCATGAGAGTGCTCTGCTTGTAG
ACTGGCCAGTGTCCATGAAACAACTGTAAATACCAACATGTGTGCATGGGTCAACAGTCTTGGCCATTTCTCATCAAAAGAAGCCAAATT
CATGATCAACATCTCTGAAGTTTCAAGTAAGGCCCACACTTCTTTGAATTACTCTTCATGGGCCCACATTAGGTTGTGCTGTGAATTACT
TAAGGCAGTGATACTGATGTAGTATAGTTTTGTCTTAATTTCCCTTATTTCTACTTCTTTGGTTGAATCTATGAACTTGATTGTATAATT
TTCTTATAAATTACTGATGTAATCAGCTTGTCAATTATGTTGTGAAATTGTTAGTATTCATTTATCAAAAATGACCTATGTTTAGTCACA
TATTTGTTTAGTTCTGGGAAATTGTTATAGCTTAAATGGAACTCACCAACATTATTCATAGTTTAAGTCTTTTATCATTATTACCTCAAT
TATAAATATTACAAAAACATAATTCTGGCAATGAGAGTATTTTTTTATTCAATGATCAAGGAGCAATGTCAGTATATAGTAGAATATCAA
TTAAATTATATCCTAAAATGTATATTTTGCATAAAAGAGATATTCTTTAATCAATTACTTTTTTGTGAGTTTTGTGGCAAATGAAGCTTG
TACGTGTCTTTAAAACTGTTGTAGATGAAACTGTATAAGATTTTTACATCTTGCTTAATCAATATTTTCAGAGTCTATTAGTTCCCCTGG
GATTCTGAATATAACATATAGCCTATTATAAATCCCTGTATCGTGGACCTTTTGTGAACATTTCAAGGCGCATGCACAACCTTGATGATA

>44432_44432_3_LEMD3-KCNC2_LEMD3_chr12_65612399_ENST00000308330_KCNC2_chr12_75445097_ENST00000350228_length(amino acids)=894AA_BP=563
MAAAAASAPQQLSDEELFSQLRRYGLSPGPVTESTRPVYLKKLKKLREEEQQQHRSGGRGNKTRNSNNNNTAAATVAAAGPAAAAAAGMG
VRPVSGDLSYLRTPGGLCRISASGPESLLGGPGGASAAPAAGSKVLLGFSSDESDVEASPRDQAGGGGRKDRASLQYRGLKAPPAPLAAS
EVTNSNSAERRKPHSWWGARRPAGPELQTPPGKDGAVEDEEGEGEDGEERDPETEEPLWASRTVNGSRLVPYSCRENYSDSEEEDDDDVA
SSRQVLKDDSLSRHRPRRTHSKPLPPLTAKSAGGRLETSVQGGGGLAMNDRAAAAGSLDRSRNLEEAAAAEQGGGCDQVDSSPVPRYRVN
AKKLTPLLPPPLTDMDSTLDSSTGSLLKTNNHIGGGAFSVDSPRIYSNSLPPSAAVAASSSLRINHANHTGSNHTYLKNTYNKPKLSEPE
EELLQQFKREEVSPTGSFSAHYLSMFLLTAACLFFLILGLTYLGMRGTGVSEDGELSIENPFGETFGKIQESEKTLMMNTLYKLHDRLAQ
LAGDHECGSSSQRTLSVQEAAAYLKFIAFASLFFILVSITTFCLETHEAFNIVKNKTEPVINGTSVVLQYEIETDPALTYVEGVCVVWFT
FEFLVRIVFSPNKLEFIKNLLNIIDFVAILPFYLEVGLSGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLL
LIIFLALGVLIFATMIYYAERVGAQPNDPSASEHTQFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTIAMPVPVIVN

--------------------------------------------------------------
>44432_44432_4_LEMD3-KCNC2_LEMD3_chr12_65612399_ENST00000308330_KCNC2_chr12_75445097_ENST00000393288_length(transcript)=3271nt_BP=1721nt
AGCTTGTAAAACACCCTGGAGAGAAAATGGCGGCGGCAGCAGCTTCGGCGCCTCAGCAGCTCTCGGATGAGGAGCTTTTCTCTCAGCTCC
GCCGTTACGGCCTGTCTCCCGGACCAGTGACGGAGAGCACCCGCCCGGTCTACCTCAAGAAGCTGAAGAAGCTTCGAGAGGAAGAGCAGC
AACAGCACCGGTCAGGGGGCCGCGGCAACAAGACGCGGAACAGTAATAACAATAACACGGCAGCCGCCACGGTCGCAGCCGCGGGACCAG
CGGCGGCGGCGGCCGCGGGGATGGGGGTCCGGCCGGTCTCGGGCGACCTCTCCTACTTACGGACTCCTGGGGGCCTGTGCCGAATCTCGG
CCTCTGGCCCAGAGAGCCTCCTGGGAGGGCCCGGGGGCGCCTCCGCCGCCCCCGCGGCTGGCAGCAAAGTGCTGCTGGGCTTCAGCTCGG
ACGAGTCGGACGTGGAGGCCAGTCCCCGGGACCAGGCCGGCGGCGGCGGGAGGAAAGACCGGGCTTCGCTCCAGTACCGCGGGCTCAAAG
CGCCGCCGGCGCCCCTGGCCGCCAGCGAGGTGACTAACAGCAACTCTGCAGAGCGAAGGAAGCCCCACTCGTGGTGGGGGGCCAGGAGGC
CGGCGGGCCCCGAGCTGCAGACCCCGCCGGGGAAAGATGGAGCAGTGGAGGACGAGGAAGGGGAGGGAGAGGACGGTGAGGAGAGGGACC
CGGAGACCGAGGAGCCGCTCTGGGCGAGCCGGACCGTGAATGGCAGCCGGCTTGTCCCCTACAGCTGCCGGGAAAACTATTCGGACTCAG
AGGAAGAGGACGACGACGACGTGGCCTCCAGCAGACAGGTATTAAAGGACGACTCCCTTTCCCGGCATCGGCCCAGACGAACCCATAGTA
AGCCTCTCCCCCCGCTGACTGCTAAATCGGCCGGCGGCAGGCTGGAGACTTCAGTTCAGGGAGGGGGAGGACTCGCGATGAATGACAGGG
CGGCGGCTGCCGGGAGTCTAGACAGGAGCCGAAACCTCGAAGAGGCGGCGGCCGCGGAGCAGGGAGGAGGGTGTGATCAAGTGGACTCCA
GCCCCGTTCCTAGATACCGTGTTAACGCTAAGAAACTGACCCCTCTCCTGCCCCCGCCACTTACTGACATGGACTCAACCTTGGATTCGT
CAACAGGCTCCCTTCTGAAAACCAATAATCATATTGGCGGTGGGGCCTTCAGTGTGGACTCCCCCAGGATTTATTCTAACAGTCTCCCTC
CCAGTGCGGCGGTGGCCGCCTCTAGTTCACTCAGGATCAATCACGCCAATCATACGGGCTCCAATCATACCTACCTGAAAAACACATACA
ACAAACCGAAGCTTTCCGAACCCGAAGAGGAACTTCTCCAGCAATTTAAACGGGAGGAGGTGTCCCCAACAGGGAGTTTCAGTGCCCACT
ACTTGTCGATGTTTCTCTTAACTGCTGCCTGCTTATTTTTCCTAATACTGGGACTGACTTACCTAGGAATGAGAGGGACAGGAGTATCTG
AGGATGGAGAACTCAGCATAGAAAACCCCTTTGGTGAAACATTTGGAAAAATACAAGAAAGTGAAAAAACTCTTATGATGAACACATTAT
ATAAGCTTCATGATCGATTGGCACAGCTTGCAGGAGATCATGAATGTGGCAGTTCTAGTCAAAGAACGCTTTCTGTTCAAGAGGCAGCTG
CGTATTTAAAATTTATTGCTTTTGCTTCTTTATTCTTCATCCTGGTTTCAATTACAACTTTTTGCCTGGAAACACATGAAGCTTTCAATA
TTGTTAAAAACAAGACAGAACCAGTCATCAATGGCACAAGTGTTGTTCTACAGTATGAAATTGAAACGGATCCTGCCTTGACGTATGTAG
AAGGAGTGTGTGTGGTGTGGTTTACTTTTGAATTTTTAGTCCGTATTGTTTTTTCACCCAATAAACTTGAATTCATCAAAAATCTCTTGA
ATATCATTGACTTTGTGGCCATCCTACCTTTCTACTTAGAGGTGGGACTCAGTGGGCTGTCATCCAAAGCTGCTAAAGATGTGCTTGGCT
TCCTCAGGGTGGTAAGGTTTGTGAGGATCCTGAGAATTTTCAAGCTCACCCGCCATTTTGTAGGTCTGAGGGTGCTTGGACATACTCTTC
GAGCTAGTACTAATGAATTTTTGCTGCTGATAATTTTCCTGGCTCTAGGAGTTTTGATATTTGCTACCATGATCTACTATGCCGAGAGAG
TGGGAGCTCAACCTAACGACCCTTCAGCTAGTGAGCACACACAGTTCAAAAACATTCCCATTGGGTTCTGGTGGGCTGTAGTGACCATGA
CTACCCTGGGTTATGGGGATATGTACCCCCAAACATGGTCAGGCATGCTGGTGGGAGCCCTGTGTGCTCTGGCTGGAGTGCTGACAATAG
CCATGCCAGTGCCTGTCATTGTCAATAATTTTGGAATGTACTACTCCTTGGCAATGGCAAAGCAGAAACTTCCAAGGAAAAGAAAGAAGC
ACATCCCTCCTGCTCCTCAGGCAAGCTCACCTACTTTTTGCAAGACAGAATTAAATATGGCCTGCAATAGTACACAGAGTGACACATGTC
TGGGCAAAGACAATCGACTTCTGGAACATAACAGATCAGTGTTATCAGGTGACGACAGTACAGGAAGTGAGCCGCCACTATCACCCCCAG
AAAGGCTCCCCATCAGACGCTCTAGTACCAGAGACAAAAACAGAAGAGGGGAAACATGTTTCCTACTGACGACAGGTGATTACACGTGTG
CTTCTGATGGAGGGATCAGGAAAGGAATTAGAAATGGGCATTCCATCCTACATCACCTGGATAATGGCACCAAATGCCATTATTTAAGAA
TCATCTTTTAACCCTATAAAGCTGGAAGATTAAATATGCTGGAAAAAGAGTTGTCCATTTAAACTTAAGTATGCTTTATTGGCTTAGGAA
ATAAAAAATGAAAAGAGAAAAAGTAGCCTACTTATTTCTCTTTTTTTCAAGAATACATTCTGAAATTTAAAAATATTAGTCAAGCTTATA
TCTTACTTAAGTTGCTTTGCCTAATTTTTAAATGAGTTCTAGTATTCTATATGCCAAAATTATATTAATGCTAACTATAATCTGGGAAAA
AATATATTTTGAAGTATTGTAACAATAATTTGTGATGGCTGGTTTAATCTTTTCAAAATGGCAACTACAGTGAGCTTCATTTTTTTAGAG

>44432_44432_4_LEMD3-KCNC2_LEMD3_chr12_65612399_ENST00000308330_KCNC2_chr12_75445097_ENST00000393288_length(amino acids)=954AA_BP=563
MAAAAASAPQQLSDEELFSQLRRYGLSPGPVTESTRPVYLKKLKKLREEEQQQHRSGGRGNKTRNSNNNNTAAATVAAAGPAAAAAAGMG
VRPVSGDLSYLRTPGGLCRISASGPESLLGGPGGASAAPAAGSKVLLGFSSDESDVEASPRDQAGGGGRKDRASLQYRGLKAPPAPLAAS
EVTNSNSAERRKPHSWWGARRPAGPELQTPPGKDGAVEDEEGEGEDGEERDPETEEPLWASRTVNGSRLVPYSCRENYSDSEEEDDDDVA
SSRQVLKDDSLSRHRPRRTHSKPLPPLTAKSAGGRLETSVQGGGGLAMNDRAAAAGSLDRSRNLEEAAAAEQGGGCDQVDSSPVPRYRVN
AKKLTPLLPPPLTDMDSTLDSSTGSLLKTNNHIGGGAFSVDSPRIYSNSLPPSAAVAASSSLRINHANHTGSNHTYLKNTYNKPKLSEPE
EELLQQFKREEVSPTGSFSAHYLSMFLLTAACLFFLILGLTYLGMRGTGVSEDGELSIENPFGETFGKIQESEKTLMMNTLYKLHDRLAQ
LAGDHECGSSSQRTLSVQEAAAYLKFIAFASLFFILVSITTFCLETHEAFNIVKNKTEPVINGTSVVLQYEIETDPALTYVEGVCVVWFT
FEFLVRIVFSPNKLEFIKNLLNIIDFVAILPFYLEVGLSGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLL
LIIFLALGVLIFATMIYYAERVGAQPNDPSASEHTQFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTIAMPVPVIVN
NFGMYYSLAMAKQKLPRKRKKHIPPAPQASSPTFCKTELNMACNSTQSDTCLGKDNRLLEHNRSVLSGDDSTGSEPPLSPPERLPIRRSS

--------------------------------------------------------------
>44432_44432_5_LEMD3-KCNC2_LEMD3_chr12_65612399_ENST00000308330_KCNC2_chr12_75445097_ENST00000540018_length(transcript)=2930nt_BP=1721nt
AGCTTGTAAAACACCCTGGAGAGAAAATGGCGGCGGCAGCAGCTTCGGCGCCTCAGCAGCTCTCGGATGAGGAGCTTTTCTCTCAGCTCC
GCCGTTACGGCCTGTCTCCCGGACCAGTGACGGAGAGCACCCGCCCGGTCTACCTCAAGAAGCTGAAGAAGCTTCGAGAGGAAGAGCAGC
AACAGCACCGGTCAGGGGGCCGCGGCAACAAGACGCGGAACAGTAATAACAATAACACGGCAGCCGCCACGGTCGCAGCCGCGGGACCAG
CGGCGGCGGCGGCCGCGGGGATGGGGGTCCGGCCGGTCTCGGGCGACCTCTCCTACTTACGGACTCCTGGGGGCCTGTGCCGAATCTCGG
CCTCTGGCCCAGAGAGCCTCCTGGGAGGGCCCGGGGGCGCCTCCGCCGCCCCCGCGGCTGGCAGCAAAGTGCTGCTGGGCTTCAGCTCGG
ACGAGTCGGACGTGGAGGCCAGTCCCCGGGACCAGGCCGGCGGCGGCGGGAGGAAAGACCGGGCTTCGCTCCAGTACCGCGGGCTCAAAG
CGCCGCCGGCGCCCCTGGCCGCCAGCGAGGTGACTAACAGCAACTCTGCAGAGCGAAGGAAGCCCCACTCGTGGTGGGGGGCCAGGAGGC
CGGCGGGCCCCGAGCTGCAGACCCCGCCGGGGAAAGATGGAGCAGTGGAGGACGAGGAAGGGGAGGGAGAGGACGGTGAGGAGAGGGACC
CGGAGACCGAGGAGCCGCTCTGGGCGAGCCGGACCGTGAATGGCAGCCGGCTTGTCCCCTACAGCTGCCGGGAAAACTATTCGGACTCAG
AGGAAGAGGACGACGACGACGTGGCCTCCAGCAGACAGGTATTAAAGGACGACTCCCTTTCCCGGCATCGGCCCAGACGAACCCATAGTA
AGCCTCTCCCCCCGCTGACTGCTAAATCGGCCGGCGGCAGGCTGGAGACTTCAGTTCAGGGAGGGGGAGGACTCGCGATGAATGACAGGG
CGGCGGCTGCCGGGAGTCTAGACAGGAGCCGAAACCTCGAAGAGGCGGCGGCCGCGGAGCAGGGAGGAGGGTGTGATCAAGTGGACTCCA
GCCCCGTTCCTAGATACCGTGTTAACGCTAAGAAACTGACCCCTCTCCTGCCCCCGCCACTTACTGACATGGACTCAACCTTGGATTCGT
CAACAGGCTCCCTTCTGAAAACCAATAATCATATTGGCGGTGGGGCCTTCAGTGTGGACTCCCCCAGGATTTATTCTAACAGTCTCCCTC
CCAGTGCGGCGGTGGCCGCCTCTAGTTCACTCAGGATCAATCACGCCAATCATACGGGCTCCAATCATACCTACCTGAAAAACACATACA
ACAAACCGAAGCTTTCCGAACCCGAAGAGGAACTTCTCCAGCAATTTAAACGGGAGGAGGTGTCCCCAACAGGGAGTTTCAGTGCCCACT
ACTTGTCGATGTTTCTCTTAACTGCTGCCTGCTTATTTTTCCTAATACTGGGACTGACTTACCTAGGAATGAGAGGGACAGGAGTATCTG
AGGATGGAGAACTCAGCATAGAAAACCCCTTTGGTGAAACATTTGGAAAAATACAAGAAAGTGAAAAAACTCTTATGATGAACACATTAT
ATAAGCTTCATGATCGATTGGCACAGCTTGCAGGAGATCATGAATGTGGCAGTTCTAGTCAAAGAACGCTTTCTGTTCAAGAGGCAGCTG
CGTATTTAAAATTTATTGCTTTTGCTTCTTTATTCTTCATCCTGGTTTCAATTACAACTTTTTGCCTGGAAACACATGAAGCTTTCAATA
TTGTTAAAAACAAGACAGAACCAGTCATCAATGGCACAAGTGTTGTTCTACAGTATGAAATTGAAACGGATCCTGCCTTGACGTATGTAG
AAGGAGTGTGTGTGGTGTGGTTTACTTTTGAATTTTTAGTCCGTATTGTTTTTTCACCCAATAAACTTGAATTCATCAAAAATCTCTTGA
ATATCATTGACTTTGTGGCCATCCTACCTTTCTACTTAGAGGTGGGACTCAGTGGGCTGTCATCCAAAGCTGCTAAAGATGTGCTTGGCT
TCCTCAGGGTGGTAAGGTTTGTGAGGATCCTGAGAATTTTCAAGCTCACCCGCCATTTTGTAGGTCTGAGGGTGCTTGGACATACTCTTC
GAGCTAGTACTAATGAATTTTTGCTGCTGATAATTTTCCTGGCTCTAGGAGTTTTGATATTTGCTACCATGATCTACTATGCCGAGAGAG
TGGGAGCTCAACCTAACGACCCTTCAGCTAGTGAGCACACACAGTTCAAAAACATTCCCATTGGGTTCTGGTGGGCTGTAGTGACCATGA
CTACCCTGGGTTATGGGGATATGTACCCCCAAACATGGTCAGGCATGCTGGTGGGAGCCCTGTGTGCTCTGGCTGGAGTGCTGACAATAG
CCATGCCAGTGCCTGTCATTGTCAATAATTTTGGAATGTACTACTCCTTGGCAATGGCAAAGCAGAAACTTCCAAGGAAAAGAAAGAAGC
ACATCCCTCCTGCTCCTCAGGCAAGCTCACCTACTTTTTGCAAGACAGAATTAAATATGGCCTGCAATAGTACACAGAGTGACACATGTC
TGGGCAAAGACAATCGACTTCTGGAACATAACAGATCAGGATATGAAAAATCCCGAAGCTTAAACAACATAGCGGGCTTGGCAGGCAATG
CTCTGAGGCTCTCTCCAGTAACATCACCCTACAACTCTCCTTGTCCTCTGAGGCGCTCTCGATCTCCCATCCCATCTATCTTGTAAACCA
AACAACCAAACTGCATCAGTCGGCTAAATTGTATTAATTCAAGTGCTGTTTACCCCATAATGGAAATAATTAAATGTAGAGTTACTCCAG

>44432_44432_5_LEMD3-KCNC2_LEMD3_chr12_65612399_ENST00000308330_KCNC2_chr12_75445097_ENST00000540018_length(amino acids)=919AA_BP=563
MAAAAASAPQQLSDEELFSQLRRYGLSPGPVTESTRPVYLKKLKKLREEEQQQHRSGGRGNKTRNSNNNNTAAATVAAAGPAAAAAAGMG
VRPVSGDLSYLRTPGGLCRISASGPESLLGGPGGASAAPAAGSKVLLGFSSDESDVEASPRDQAGGGGRKDRASLQYRGLKAPPAPLAAS
EVTNSNSAERRKPHSWWGARRPAGPELQTPPGKDGAVEDEEGEGEDGEERDPETEEPLWASRTVNGSRLVPYSCRENYSDSEEEDDDDVA
SSRQVLKDDSLSRHRPRRTHSKPLPPLTAKSAGGRLETSVQGGGGLAMNDRAAAAGSLDRSRNLEEAAAAEQGGGCDQVDSSPVPRYRVN
AKKLTPLLPPPLTDMDSTLDSSTGSLLKTNNHIGGGAFSVDSPRIYSNSLPPSAAVAASSSLRINHANHTGSNHTYLKNTYNKPKLSEPE
EELLQQFKREEVSPTGSFSAHYLSMFLLTAACLFFLILGLTYLGMRGTGVSEDGELSIENPFGETFGKIQESEKTLMMNTLYKLHDRLAQ
LAGDHECGSSSQRTLSVQEAAAYLKFIAFASLFFILVSITTFCLETHEAFNIVKNKTEPVINGTSVVLQYEIETDPALTYVEGVCVVWFT
FEFLVRIVFSPNKLEFIKNLLNIIDFVAILPFYLEVGLSGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLL
LIIFLALGVLIFATMIYYAERVGAQPNDPSASEHTQFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTIAMPVPVIVN
NFGMYYSLAMAKQKLPRKRKKHIPPAPQASSPTFCKTELNMACNSTQSDTCLGKDNRLLEHNRSGYEKSRSLNNIAGLAGNALRLSPVTS

--------------------------------------------------------------
>44432_44432_6_LEMD3-KCNC2_LEMD3_chr12_65612399_ENST00000308330_KCNC2_chr12_75445097_ENST00000548513_length(transcript)=4039nt_BP=1721nt
AGCTTGTAAAACACCCTGGAGAGAAAATGGCGGCGGCAGCAGCTTCGGCGCCTCAGCAGCTCTCGGATGAGGAGCTTTTCTCTCAGCTCC
GCCGTTACGGCCTGTCTCCCGGACCAGTGACGGAGAGCACCCGCCCGGTCTACCTCAAGAAGCTGAAGAAGCTTCGAGAGGAAGAGCAGC
AACAGCACCGGTCAGGGGGCCGCGGCAACAAGACGCGGAACAGTAATAACAATAACACGGCAGCCGCCACGGTCGCAGCCGCGGGACCAG
CGGCGGCGGCGGCCGCGGGGATGGGGGTCCGGCCGGTCTCGGGCGACCTCTCCTACTTACGGACTCCTGGGGGCCTGTGCCGAATCTCGG
CCTCTGGCCCAGAGAGCCTCCTGGGAGGGCCCGGGGGCGCCTCCGCCGCCCCCGCGGCTGGCAGCAAAGTGCTGCTGGGCTTCAGCTCGG
ACGAGTCGGACGTGGAGGCCAGTCCCCGGGACCAGGCCGGCGGCGGCGGGAGGAAAGACCGGGCTTCGCTCCAGTACCGCGGGCTCAAAG
CGCCGCCGGCGCCCCTGGCCGCCAGCGAGGTGACTAACAGCAACTCTGCAGAGCGAAGGAAGCCCCACTCGTGGTGGGGGGCCAGGAGGC
CGGCGGGCCCCGAGCTGCAGACCCCGCCGGGGAAAGATGGAGCAGTGGAGGACGAGGAAGGGGAGGGAGAGGACGGTGAGGAGAGGGACC
CGGAGACCGAGGAGCCGCTCTGGGCGAGCCGGACCGTGAATGGCAGCCGGCTTGTCCCCTACAGCTGCCGGGAAAACTATTCGGACTCAG
AGGAAGAGGACGACGACGACGTGGCCTCCAGCAGACAGGTATTAAAGGACGACTCCCTTTCCCGGCATCGGCCCAGACGAACCCATAGTA
AGCCTCTCCCCCCGCTGACTGCTAAATCGGCCGGCGGCAGGCTGGAGACTTCAGTTCAGGGAGGGGGAGGACTCGCGATGAATGACAGGG
CGGCGGCTGCCGGGAGTCTAGACAGGAGCCGAAACCTCGAAGAGGCGGCGGCCGCGGAGCAGGGAGGAGGGTGTGATCAAGTGGACTCCA
GCCCCGTTCCTAGATACCGTGTTAACGCTAAGAAACTGACCCCTCTCCTGCCCCCGCCACTTACTGACATGGACTCAACCTTGGATTCGT
CAACAGGCTCCCTTCTGAAAACCAATAATCATATTGGCGGTGGGGCCTTCAGTGTGGACTCCCCCAGGATTTATTCTAACAGTCTCCCTC
CCAGTGCGGCGGTGGCCGCCTCTAGTTCACTCAGGATCAATCACGCCAATCATACGGGCTCCAATCATACCTACCTGAAAAACACATACA
ACAAACCGAAGCTTTCCGAACCCGAAGAGGAACTTCTCCAGCAATTTAAACGGGAGGAGGTGTCCCCAACAGGGAGTTTCAGTGCCCACT
ACTTGTCGATGTTTCTCTTAACTGCTGCCTGCTTATTTTTCCTAATACTGGGACTGACTTACCTAGGAATGAGAGGGACAGGAGTATCTG
AGGATGGAGAACTCAGCATAGAAAACCCCTTTGGTGAAACATTTGGAAAAATACAAGAAAGTGAAAAAACTCTTATGATGAACACATTAT
ATAAGCTTCATGATCGATTGGCACAGCTTGCAGGAGATCATGAATGTGGCAGTTCTAGTCAAAGAACGCTTTCTGTTCAAGAGGCAGCTG
CGTATTTAAAATTTATTGCTTTTGCTTCTTTATTCTTCATCCTGGTTTCAATTACAACTTTTTGCCTGGAAACACATGAAGCTTTCAATA
TTGTTAAAAACAAGACAGAACCAGTCATCAATGGCACAAGTGTTGTTCTACAGTATGAAATTGAAACGGATCCTGCCTTGACGTATGTAG
AAGGAGTGTGTGTGGTGTGGTTTACTTTTGAATTTTTAGTCCGTATTGTTTTTTCACCCAATAAACTTGAATTCATCAAAAATCTCTTGA
ATATCATTGACTTTGTGGCCATCCTACCTTTCTACTTAGAGGTGGGACTCAGTGGGCTGTCATCCAAAGCTGCTAAAGATGTGCTTGGCT
TCCTCAGGGTGGTAAGGTTTGTGAGGATCCTGAGAATTTTCAAGCTCACCCGCCATTTTGTAGGTCTGAGGGTGCTTGGACATACTCTTC
GAGCTAGTACTAATGAATTTTTGCTGCTGATAATTTTCCTGGCTCTAGGAGTTTTGATATTTGCTACCATGATCTACTATGCCGAGAGAG
TGGGAGCTCAACCTAACGACCCTTCAGCTAGTGAGCACACACAGTTCAAAAACATTCCCATTGGGTTCTGGTGGGCTGTAGTGACCATGA
CTACCCTGGGTTATGGGGATATGTACCCCCAAACATGGTCAGGCATGCTGGTGGGAGCCCTGTGTGCTCTGGCTGGAGTGCTGACAATAG
CCATGCCAGTGCCTGTCATTGTCAATAATTTTGGAATGTACTACTCCTTGGCAATGGCAAAGCAGAAACTTCCAAGGAAAAGAAAGAAGC
ACATCCCTCCTGCTCCTCAGGCAAGCTCACCTACTTTTTGCAAGACAGAATTAAATATGGCCTGCAATAGTACACAGAGTGACACATGTC
TGGGCAAAGACAATCGACTTCTGGAACATAACAGATCAGTGTTATCAGGTGACGACAGTACAGGAAGTGAGCCGCCACTATCACCCCCAG
AAAGGCTCCCCATCAGACGCTCTAGTACCAGAGACAAAAACAGAAGAGGGGAAACATGTTTCCTACTGACGACAGGTGATTACACGTGTG
CTTCTGATGGAGGGATCAGGAAAGATAACTGCAAAGAGGTTGTCATTACTGGTTACACGCAAGCCGAGGCCAGATCTCTTACTTAATGAC
TTGGGGAAGGCACAAAACATGAGAGAAAGTGTTGTACAGAATTTATCATGGATTATTGACTGCTGAGAAAGGGACAGTGGAATTTAGCCA
TACCAAGGACTATACTGGAAACAGACTTCTGCTGCTGAATGTGCCCTGATGTGACCAGGTTGCACTTGGAAGAGATCCTCGCGTCTTCAT
GAGGCACTTAAAGCTTATAAAAGAACTGCGGCTGGAACTCATCTGGTGCTCCCCATGAGAGTGCTCTGCTTGTAGACTGGCCAGTGTCCA
TGAAACAACTGTAAATACCAACATGTGTGCATGGGTCAACAGTCTTGGCCATTTCTCATCAAAAGAAGCCAAATTCATGATCAACATCTC
TGAAGTTTCAAGTAAGGCCCACACTTCTTTGAATTACTCTTCATGGGCCCACATTAGGTTGTGCTGTGAATTACTTAAGGCAGTGATACT
GATGTAGTATAGTTTTGTCTTAATTTCCCTTATTTCTACTTCTTTGGTTGAATCTATGAACTTGATTGTATAATTTTCTTATAAATTACT
GATGTAATCAGCTTGTCAATTATGTTGTGAAATTGTTAGTATTCATTTATCAAAAATGACCTATGTTTAGTCACATATTTGTTTAGTTCT
GGGAAATTGTTATAGCTTAAATGGAACTCACCAACATTATTCATAGTTTAAGTCTTTTATCATTATTACCTCAATTATAAATATTACAAA
AACATAATTCTGGCAATGAGAGTATTTTTTTATTCAATGATCAAGGAGCAATGTCAGTATATAGTAGAATATCAATTAAATTATATCCTA
AAATGTATATTTTGCATAAAAGAGATATTCTTTAATCAATTACTTTTTTGTGAGTTTTGTGGCAAATGAAGCTTGTACGTGTCTTTAAAA
CTGTTGTAGATGAAACTGTATAAGATTTTTACATCTTGCTTAATCAATATTTTCAGAGTCTATTAGTTCCCCTGGGATTCTGAATATAAC
ATATAGCCTATTATAAATCCCTGTATCGTGGACCTTTTGTGAACATTTCAAGGCGCATGCACAACCTTGATGATAACCAGTGGAAATGTA

>44432_44432_6_LEMD3-KCNC2_LEMD3_chr12_65612399_ENST00000308330_KCNC2_chr12_75445097_ENST00000548513_length(amino acids)=949AA_BP=563
MAAAAASAPQQLSDEELFSQLRRYGLSPGPVTESTRPVYLKKLKKLREEEQQQHRSGGRGNKTRNSNNNNTAAATVAAAGPAAAAAAGMG
VRPVSGDLSYLRTPGGLCRISASGPESLLGGPGGASAAPAAGSKVLLGFSSDESDVEASPRDQAGGGGRKDRASLQYRGLKAPPAPLAAS
EVTNSNSAERRKPHSWWGARRPAGPELQTPPGKDGAVEDEEGEGEDGEERDPETEEPLWASRTVNGSRLVPYSCRENYSDSEEEDDDDVA
SSRQVLKDDSLSRHRPRRTHSKPLPPLTAKSAGGRLETSVQGGGGLAMNDRAAAAGSLDRSRNLEEAAAAEQGGGCDQVDSSPVPRYRVN
AKKLTPLLPPPLTDMDSTLDSSTGSLLKTNNHIGGGAFSVDSPRIYSNSLPPSAAVAASSSLRINHANHTGSNHTYLKNTYNKPKLSEPE
EELLQQFKREEVSPTGSFSAHYLSMFLLTAACLFFLILGLTYLGMRGTGVSEDGELSIENPFGETFGKIQESEKTLMMNTLYKLHDRLAQ
LAGDHECGSSSQRTLSVQEAAAYLKFIAFASLFFILVSITTFCLETHEAFNIVKNKTEPVINGTSVVLQYEIETDPALTYVEGVCVVWFT
FEFLVRIVFSPNKLEFIKNLLNIIDFVAILPFYLEVGLSGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLL
LIIFLALGVLIFATMIYYAERVGAQPNDPSASEHTQFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTIAMPVPVIVN
NFGMYYSLAMAKQKLPRKRKKHIPPAPQASSPTFCKTELNMACNSTQSDTCLGKDNRLLEHNRSVLSGDDSTGSEPPLSPPERLPIRRSS

--------------------------------------------------------------
>44432_44432_7_LEMD3-KCNC2_LEMD3_chr12_65612399_ENST00000308330_KCNC2_chr12_75445097_ENST00000549446_length(transcript)=5978nt_BP=1721nt
AGCTTGTAAAACACCCTGGAGAGAAAATGGCGGCGGCAGCAGCTTCGGCGCCTCAGCAGCTCTCGGATGAGGAGCTTTTCTCTCAGCTCC
GCCGTTACGGCCTGTCTCCCGGACCAGTGACGGAGAGCACCCGCCCGGTCTACCTCAAGAAGCTGAAGAAGCTTCGAGAGGAAGAGCAGC
AACAGCACCGGTCAGGGGGCCGCGGCAACAAGACGCGGAACAGTAATAACAATAACACGGCAGCCGCCACGGTCGCAGCCGCGGGACCAG
CGGCGGCGGCGGCCGCGGGGATGGGGGTCCGGCCGGTCTCGGGCGACCTCTCCTACTTACGGACTCCTGGGGGCCTGTGCCGAATCTCGG
CCTCTGGCCCAGAGAGCCTCCTGGGAGGGCCCGGGGGCGCCTCCGCCGCCCCCGCGGCTGGCAGCAAAGTGCTGCTGGGCTTCAGCTCGG
ACGAGTCGGACGTGGAGGCCAGTCCCCGGGACCAGGCCGGCGGCGGCGGGAGGAAAGACCGGGCTTCGCTCCAGTACCGCGGGCTCAAAG
CGCCGCCGGCGCCCCTGGCCGCCAGCGAGGTGACTAACAGCAACTCTGCAGAGCGAAGGAAGCCCCACTCGTGGTGGGGGGCCAGGAGGC
CGGCGGGCCCCGAGCTGCAGACCCCGCCGGGGAAAGATGGAGCAGTGGAGGACGAGGAAGGGGAGGGAGAGGACGGTGAGGAGAGGGACC
CGGAGACCGAGGAGCCGCTCTGGGCGAGCCGGACCGTGAATGGCAGCCGGCTTGTCCCCTACAGCTGCCGGGAAAACTATTCGGACTCAG
AGGAAGAGGACGACGACGACGTGGCCTCCAGCAGACAGGTATTAAAGGACGACTCCCTTTCCCGGCATCGGCCCAGACGAACCCATAGTA
AGCCTCTCCCCCCGCTGACTGCTAAATCGGCCGGCGGCAGGCTGGAGACTTCAGTTCAGGGAGGGGGAGGACTCGCGATGAATGACAGGG
CGGCGGCTGCCGGGAGTCTAGACAGGAGCCGAAACCTCGAAGAGGCGGCGGCCGCGGAGCAGGGAGGAGGGTGTGATCAAGTGGACTCCA
GCCCCGTTCCTAGATACCGTGTTAACGCTAAGAAACTGACCCCTCTCCTGCCCCCGCCACTTACTGACATGGACTCAACCTTGGATTCGT
CAACAGGCTCCCTTCTGAAAACCAATAATCATATTGGCGGTGGGGCCTTCAGTGTGGACTCCCCCAGGATTTATTCTAACAGTCTCCCTC
CCAGTGCGGCGGTGGCCGCCTCTAGTTCACTCAGGATCAATCACGCCAATCATACGGGCTCCAATCATACCTACCTGAAAAACACATACA
ACAAACCGAAGCTTTCCGAACCCGAAGAGGAACTTCTCCAGCAATTTAAACGGGAGGAGGTGTCCCCAACAGGGAGTTTCAGTGCCCACT
ACTTGTCGATGTTTCTCTTAACTGCTGCCTGCTTATTTTTCCTAATACTGGGACTGACTTACCTAGGAATGAGAGGGACAGGAGTATCTG
AGGATGGAGAACTCAGCATAGAAAACCCCTTTGGTGAAACATTTGGAAAAATACAAGAAAGTGAAAAAACTCTTATGATGAACACATTAT
ATAAGCTTCATGATCGATTGGCACAGCTTGCAGGAGATCATGAATGTGGCAGTTCTAGTCAAAGAACGCTTTCTGTTCAAGAGGCAGCTG
CGTATTTAAAATTTATTGCTTTTGCTTCTTTATTCTTCATCCTGGTTTCAATTACAACTTTTTGCCTGGAAACACATGAAGCTTTCAATA
TTGTTAAAAACAAGACAGAACCAGTCATCAATGGCACAAGTGTTGTTCTACAGTATGAAATTGAAACGGATCCTGCCTTGACGTATGTAG
AAGGAGTGTGTGTGGTGTGGTTTACTTTTGAATTTTTAGTCCGTATTGTTTTTTCACCCAATAAACTTGAATTCATCAAAAATCTCTTGA
ATATCATTGACTTTGTGGCCATCCTACCTTTCTACTTAGAGGTGGGACTCAGTGGGCTGTCATCCAAAGCTGCTAAAGATGTGCTTGGCT
TCCTCAGGGTGGTAAGGTTTGTGAGGATCCTGAGAATTTTCAAGCTCACCCGCCATTTTGTAGGTCTGAGGGTGCTTGGACATACTCTTC
GAGCTAGTACTAATGAATTTTTGCTGCTGATAATTTTCCTGGCTCTAGGAGTTTTGATATTTGCTACCATGATCTACTATGCCGAGAGAG
TGGGAGCTCAACCTAACGACCCTTCAGCTAGTGAGCACACACAGTTCAAAAACATTCCCATTGGGTTCTGGTGGGCTGTAGTGACCATGA
CTACCCTGGGTTATGGGGATATGTACCCCCAAACATGGTCAGGCATGCTGGTGGGAGCCCTGTGTGCTCTGGCTGGAGTGCTGACAATAG
CCATGCCAGTGCCTGTCATTGTCAATAATTTTGGAATGTACTACTCCTTGGCAATGGCAAAGCAGAAACTTCCAAGGAAAAGAAAGAAGC
ACATCCCTCCTGCTCCTCAGGCAAGCTCACCTACTTTTTGCAAGACAGAATTAAATATGGCCTGCAATAGTACACAGAGTGACACATGTC
TGGGCAAAGACAATCGACTTCTGGAACATAACAGATCAGTGTTATCAGGTGACGACAGTACAGGAAGTGAGCCGCCACTATCACCCCCAG
AAAGGCTCCCCATCAGACGCTCTAGTACCAGAGACAAAAACAGAAGAGGGGAAACATGTTTCCTACTGACGACAGGTGATTACACGTGTG
CTTCTGATGGAGGGATCAGGAAAGGATATGAAAAATCCCGAAGCTTAAACAACATAGCGGGCTTGGCAGGCAATGCTCTGAGGCTCTCTC
CAGTAACATCACCCTACAACTCTCCTTGTCCTCTGAGGCGCTCTCGATCTCCCATCCCATCTATCTTGTAAACCAAACAACCAAACTGCA
TCAGTCGGCTAAATTGTATTAATTCAAGTGCTGTTTACCCCATAATGGAAATAATTAAATGTAGAGTTACTCCAGGCTCCATTAATACAG
TATAAATCTTGCATGATACTACAATTTGAAGTCAGAAATGCCACTTGGGTAGCTAATGAATCTTACCCAGGCTTTAAAGATTGTCTAAAG
TAGTGCTAAGATCCCTCCTATTAATTGCCCTGATATCCTTTTGCAATAAAATGACAGATAGTGTCAGATATTGACCAGTGCACTAATATA
TAAACATACCTTCAGGGAGATATATTTAAAACAGTGTGCTTCCAAATGCCAACCACTTCATTGGAACTTTATTTCTTGTGACTGTAAACC
ATTCTGAAGATGTCTGGGATCCTATCTTGATTGCACACGACATGACTTGTGTCAGCTCATTTGCATGGACCATCTTGTCTCTATCACCTG
AAAGCAATGTTGCAGAGTTCGGGGACTGTGGATAGCTCAGGATATGTGTACTTGCATCGAACCATCCTGCTGATATGAAAGCATTGGTCG
ACTGTTCTGCATGTTGAATTGTGGGGCAGGGAGGGCACTTTTCTCCTTGACATTTTTTTCTTATTATTTGAAAGAAATATATGTTTTAAA
TAGTTTAATTTCTTGATTGATTTACTTTTCTTCAAAAATGCTGTATTGGAGTTCTGAATGTCTCTGGTTGTTTGCACACAGATAACTGCA
AAGAGGTTGTCATTACTGGTTACACGCAAGCCGAGGCCAGATCTCTTACTTAATGACTTGGGGAAGGCACAAAACATGAGAGAAAGGTAA
CTGCCAGCCAGGCTTGCATTGTTTAGCCAGAAATTGCTGCTTGGTTCTAGACTCTTTAAAAAAAAAAAATACCCAGGGTTTGTCATCATT
TTCAGAGGCAGAGTGCCAAATATCACCCAAAGCTCTTGTGTCTTTTTTTTACCCCCTTATTTTATTTTTATTTATTAATTTTTTGTGCAA
ACATCAAATGTCACTGGTGTTCACAGAAGGCTTTTTTGACTAGCCTTAAATTCCTGAGTCAAAAGATTAATCAGATTTTCAGGCAGTGTT
TAATCAGGTGCTTTGTCCTGTATGTTGTTCTTGTCTGTCTTAGCTCCCTGTCTTTCCTGTATATGCCATCTGTCTCCATGAAGCACAGAA
ATGCCTCTGTAAGATGTTTATGATTTTAATATTTACTCCCTCCAAACCCGACTCCATACCATTTTTTGCTATTTGGAGCAGCCTCTCTGC
TTTGTGTATAAATTAATGATGCTCTGTAGACTACCTAAGTTAATCGGCACTGTGAATCTTTTTGATAAGCAGGGTTTAAGCAGCAATTTC
ACCATTGCACTTGGTTGCCTGCTGCAGTGTCAGTTTCTACTACCTAGCAACCAGCATTCATTACTACACTCCAACAAAATCCTTAGGGAG
TCATATTCAGTCTGAGTGGAAGAAAGTCTATTTATGCATTCCTATGAATTCAACAGCAATAGCGTGTCTCATGTATTGAGCATGTGAGGG
AAGAAAAAGACCGTAATATAAATAGAGGGATAAATAATATCACTAAGGCATTTGGGAGCCTTGAGACTGCTGATTAATTCCTATTTCTCA
TGTTTATTTTTTGTTAGGAAGACAATTGTCACTTTTATTATTGGCCACGAAACATGTATTACTCTATATCCCCAAGTCCTAGAGCATGAC
CTGCATGTTGGAGATGTTGTACAGCAATGTATTTATCCAGACATACATATATGATATTTAGAGACACAGTGATTCTTTTGATAACACCAC
ACATAGAACATTATAATTACACACAAATTTATGGTAAAAGAATTAATATGCTGTCTGGTGCTGCTGTTATTGACTACAGTGTTGTACAGA
ATTTATCATGGATTATTGACTGCTGAGAAAGGGACAGTGGAATTTAGCCATACCAAGGACTATACTGGAAACAGACTTCTGCTGCTGAAT
GTGCCCTGATGTGACCAGGTTGCACTTGGAAGAGATCCTCGCGTCTTCATGAGGCACTTAAAGCTTATAAAAGAACTGCGGCTGGAACTC
ATCTGGTGCTCCCCATGAGAGTGCTCTGCTTGTAGACTGGCCAGTGTCCATGAAACAACTGTAAATACCAACATGTGTGCATGGGTCAAC
AGTCTTGGCCATTTCTCATCAAAAGAAGCCAAATTCATGATCAACATCTCTGAAGTTTCAAGTAAGGCCCACACTTCTTTGAATTACTCT
TCATGGGCCCACATTAGGTTGTGCTGTGAATTACTTAAGGCAGTGATACTGATGTAGTATAGTTTTGTCTTAATTTCCCTTATTTCTACT
TCTTTGGTTGAATCTATGAACTTGATTGTATAATTTTCTTATAAATTACTGATGTAATCAGCTTGTCAATTATGTTGTGAAATTGTTAGT
ATTCATTTATCAAAAATGACCTATGTTTAGTCACATATTTGTTTAGTTCTGGGAAATTGTTATAGCTTAAATGGAACTCACCAACATTAT
TCATAGTTTAAGTCTTTTATCATTATTACCTCAATTATAAATATTACAAAAACATAATTCTGGCAATGAGAGTATTTTTTTATTCAATGA
TCAAGGAGCAATGTCAGTATATAGTAGAATATCAATTAAATTATATCCTAAAATGTATATTTTGCATAAAAGAGATATTCTTTAATCAAT
TACTTTTTTGTGAGTTTTGTGGCAAATGAAGCTTGTACGTGTCTTTAAAACTGTTGTAGATGAAACTGTATAAGATTTTTACATCTTGCT
TAATCAATATTTTCAGAGTCTATTAGTTCCCCTGGGATTCTGAATATAACATATAGCCTATTATAAATCCCTGTATCGTGGACCTTTTGT
GAACATTTCAAGGCGCATGCACAACCTTGATGATAACCAGTGGAAATGTAACTAACTGAAATGAAGAATAAAAGGCAAATGAGCTGGGGA

>44432_44432_7_LEMD3-KCNC2_LEMD3_chr12_65612399_ENST00000308330_KCNC2_chr12_75445097_ENST00000549446_length(amino acids)=974AA_BP=563
MAAAAASAPQQLSDEELFSQLRRYGLSPGPVTESTRPVYLKKLKKLREEEQQQHRSGGRGNKTRNSNNNNTAAATVAAAGPAAAAAAGMG
VRPVSGDLSYLRTPGGLCRISASGPESLLGGPGGASAAPAAGSKVLLGFSSDESDVEASPRDQAGGGGRKDRASLQYRGLKAPPAPLAAS
EVTNSNSAERRKPHSWWGARRPAGPELQTPPGKDGAVEDEEGEGEDGEERDPETEEPLWASRTVNGSRLVPYSCRENYSDSEEEDDDDVA
SSRQVLKDDSLSRHRPRRTHSKPLPPLTAKSAGGRLETSVQGGGGLAMNDRAAAAGSLDRSRNLEEAAAAEQGGGCDQVDSSPVPRYRVN
AKKLTPLLPPPLTDMDSTLDSSTGSLLKTNNHIGGGAFSVDSPRIYSNSLPPSAAVAASSSLRINHANHTGSNHTYLKNTYNKPKLSEPE
EELLQQFKREEVSPTGSFSAHYLSMFLLTAACLFFLILGLTYLGMRGTGVSEDGELSIENPFGETFGKIQESEKTLMMNTLYKLHDRLAQ
LAGDHECGSSSQRTLSVQEAAAYLKFIAFASLFFILVSITTFCLETHEAFNIVKNKTEPVINGTSVVLQYEIETDPALTYVEGVCVVWFT
FEFLVRIVFSPNKLEFIKNLLNIIDFVAILPFYLEVGLSGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLL
LIIFLALGVLIFATMIYYAERVGAQPNDPSASEHTQFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTIAMPVPVIVN
NFGMYYSLAMAKQKLPRKRKKHIPPAPQASSPTFCKTELNMACNSTQSDTCLGKDNRLLEHNRSVLSGDDSTGSEPPLSPPERLPIRRSS

--------------------------------------------------------------
>44432_44432_8_LEMD3-KCNC2_LEMD3_chr12_65612399_ENST00000308330_KCNC2_chr12_75445097_ENST00000550433_length(transcript)=3944nt_BP=1721nt
AGCTTGTAAAACACCCTGGAGAGAAAATGGCGGCGGCAGCAGCTTCGGCGCCTCAGCAGCTCTCGGATGAGGAGCTTTTCTCTCAGCTCC
GCCGTTACGGCCTGTCTCCCGGACCAGTGACGGAGAGCACCCGCCCGGTCTACCTCAAGAAGCTGAAGAAGCTTCGAGAGGAAGAGCAGC
AACAGCACCGGTCAGGGGGCCGCGGCAACAAGACGCGGAACAGTAATAACAATAACACGGCAGCCGCCACGGTCGCAGCCGCGGGACCAG
CGGCGGCGGCGGCCGCGGGGATGGGGGTCCGGCCGGTCTCGGGCGACCTCTCCTACTTACGGACTCCTGGGGGCCTGTGCCGAATCTCGG
CCTCTGGCCCAGAGAGCCTCCTGGGAGGGCCCGGGGGCGCCTCCGCCGCCCCCGCGGCTGGCAGCAAAGTGCTGCTGGGCTTCAGCTCGG
ACGAGTCGGACGTGGAGGCCAGTCCCCGGGACCAGGCCGGCGGCGGCGGGAGGAAAGACCGGGCTTCGCTCCAGTACCGCGGGCTCAAAG
CGCCGCCGGCGCCCCTGGCCGCCAGCGAGGTGACTAACAGCAACTCTGCAGAGCGAAGGAAGCCCCACTCGTGGTGGGGGGCCAGGAGGC
CGGCGGGCCCCGAGCTGCAGACCCCGCCGGGGAAAGATGGAGCAGTGGAGGACGAGGAAGGGGAGGGAGAGGACGGTGAGGAGAGGGACC
CGGAGACCGAGGAGCCGCTCTGGGCGAGCCGGACCGTGAATGGCAGCCGGCTTGTCCCCTACAGCTGCCGGGAAAACTATTCGGACTCAG
AGGAAGAGGACGACGACGACGTGGCCTCCAGCAGACAGGTATTAAAGGACGACTCCCTTTCCCGGCATCGGCCCAGACGAACCCATAGTA
AGCCTCTCCCCCCGCTGACTGCTAAATCGGCCGGCGGCAGGCTGGAGACTTCAGTTCAGGGAGGGGGAGGACTCGCGATGAATGACAGGG
CGGCGGCTGCCGGGAGTCTAGACAGGAGCCGAAACCTCGAAGAGGCGGCGGCCGCGGAGCAGGGAGGAGGGTGTGATCAAGTGGACTCCA
GCCCCGTTCCTAGATACCGTGTTAACGCTAAGAAACTGACCCCTCTCCTGCCCCCGCCACTTACTGACATGGACTCAACCTTGGATTCGT
CAACAGGCTCCCTTCTGAAAACCAATAATCATATTGGCGGTGGGGCCTTCAGTGTGGACTCCCCCAGGATTTATTCTAACAGTCTCCCTC
CCAGTGCGGCGGTGGCCGCCTCTAGTTCACTCAGGATCAATCACGCCAATCATACGGGCTCCAATCATACCTACCTGAAAAACACATACA
ACAAACCGAAGCTTTCCGAACCCGAAGAGGAACTTCTCCAGCAATTTAAACGGGAGGAGGTGTCCCCAACAGGGAGTTTCAGTGCCCACT
ACTTGTCGATGTTTCTCTTAACTGCTGCCTGCTTATTTTTCCTAATACTGGGACTGACTTACCTAGGAATGAGAGGGACAGGAGTATCTG
AGGATGGAGAACTCAGCATAGAAAACCCCTTTGGTGAAACATTTGGAAAAATACAAGAAAGTGAAAAAACTCTTATGATGAACACATTAT
ATAAGCTTCATGATCGATTGGCACAGCTTGCAGGAGATCATGAATGTGGCAGTTCTAGTCAAAGAACGCTTTCTGTTCAAGAGGCAGCTG
CGTATTTAAAATTTATTGCTTTTGCTTCTTTATTCTTCATCCTGGTTTCAATTACAACTTTTTGCCTGGAAACACATGAAGCTTTCAATA
TTGTTAAAAACAAGACAGAACCAGTCATCAATGGCACAAGTGTTGTTCTACAGTATGAAATTGAAACGGATCCTGCCTTGACGTATGTAG
AAGGAGTGTGTGTGGTGTGGTTTACTTTTGAATTTTTAGTCCGTATTGTTTTTTCACCCAATAAACTTGAATTCATCAAAAATCTCTTGA
ATATCATTGACTTTGTGGCCATCCTACCTTTCTACTTAGAGGTGGGACTCAGTGGGCTGTCATCCAAAGCTGCTAAAGATGTGCTTGGCT
TCCTCAGGGTGGTAAGGTTTGTGAGGATCCTGAGAATTTTCAAGCTCACCCGCCATTTTGTAGGTCTGAGGGTGCTTGGACATACTCTTC
GAGCTAGTACTAATGAATTTTTGCTGCTGATAATTTTCCTGGCTCTAGGAGTTTTGATATTTGCTACCATGATCTACTATGCCGAGAGAG
TGGGAGCTCAACCTAACGACCCTTCAGCTAGTGAGCACACACAGTTCAAAAACATTCCCATTGGGTTCTGGTGGGCTGTAGTGACCATGA
CTACCCTGGGTTATGGGGATATGTACCCCCAAACATGGTCAGGCATGCTGGTGGGAGCCCTGTGTGCTCTGGCTGGAGTGCTGACAATAG
CCATGCCAGTGCCTGTCATTGTCAATAATTTTGGAATGTACTACTCCTTGGCAATGGCAAAGCAGAAACTTCCAAGGAAAAGAAAGAAGC
ACATCCCTCCTGCTCCTCAGGCAAGCTCACCTACTTTTTGCAAGACAGAATTAAATATGGCCTGCAATAGTACACAGAGTGACACATGTC
TGGGCAAAGACAATCGACTTCTGGAACATAACAGATCAGTGTTATCAGGTGACGACAGTACAGGAAGTGAGCCGCCACTATCACCCCCAG
AAAGGCTCCCCATCAGACGCTCTAGTACCAGAGACAAAAACAGAAGAGGGGAAACATGTTTCCTACTGACGACAGGTGATTACACGTGTG
CTTCTGATGGAGGGATCAGGAAAGTGTTGTACAGAATTTATCATGGATTATTGACTGCTGAGAAAGGGACAGTGGAATTTAGCCATACCA
AGGACTATACTGGAAACAGACTTCTGCTGCTGAATGTGCCCTGATGTGACCAGGTTGCACTTGGAAGAGATCCTCGCGTCTTCATGAGGC
ACTTAAAGCTTATAAAAGAACTGCGGCTGGAACTCATCTGGTGCTCCCCATGAGAGTGCTCTGCTTGTAGACTGGCCAGTGTCCATGAAA
CAACTGTAAATACCAACATGTGTGCATGGGTCAACAGTCTTGGCCATTTCTCATCAAAAGAAGCCAAATTCATGATCAACATCTCTGAAG
TTTCAAGTAAGGCCCACACTTCTTTGAATTACTCTTCATGGGCCCACATTAGGTTGTGCTGTGAATTACTTAAGGCAGTGATACTGATGT
AGTATAGTTTTGTCTTAATTTCCCTTATTTCTACTTCTTTGGTTGAATCTATGAACTTGATTGTATAATTTTCTTATAAATTACTGATGT
AATCAGCTTGTCAATTATGTTGTGAAATTGTTAGTATTCATTTATCAAAAATGACCTATGTTTAGTCACATATTTGTTTAGTTCTGGGAA
ATTGTTATAGCTTAAATGGAACTCACCAACATTATTCATAGTTTAAGTCTTTTATCATTATTACCTCAATTATAAATATTACAAAAACAT
AATTCTGGCAATGAGAGTATTTTTTTATTCAATGATCAAGGAGCAATGTCAGTATATAGTAGAATATCAATTAAATTATATCCTAAAATG
TATATTTTGCATAAAAGAGATATTCTTTAATCAATTACTTTTTTGTGAGTTTTGTGGCAAATGAAGCTTGTACGTGTCTTTAAAACTGTT
GTAGATGAAACTGTATAAGATTTTTACATCTTGCTTAATCAATATTTTCAGAGTCTATTAGTTCCCCTGGGATTCTGAATATAACATATA
GCCTATTATAAATCCCTGTATCGTGGACCTTTTGTGAACATTTCAAGGCGCATGCACAACCTTGATGATAACCAGTGGAAATGTAACTAA

>44432_44432_8_LEMD3-KCNC2_LEMD3_chr12_65612399_ENST00000308330_KCNC2_chr12_75445097_ENST00000550433_length(amino acids)=965AA_BP=563
MAAAAASAPQQLSDEELFSQLRRYGLSPGPVTESTRPVYLKKLKKLREEEQQQHRSGGRGNKTRNSNNNNTAAATVAAAGPAAAAAAGMG
VRPVSGDLSYLRTPGGLCRISASGPESLLGGPGGASAAPAAGSKVLLGFSSDESDVEASPRDQAGGGGRKDRASLQYRGLKAPPAPLAAS
EVTNSNSAERRKPHSWWGARRPAGPELQTPPGKDGAVEDEEGEGEDGEERDPETEEPLWASRTVNGSRLVPYSCRENYSDSEEEDDDDVA
SSRQVLKDDSLSRHRPRRTHSKPLPPLTAKSAGGRLETSVQGGGGLAMNDRAAAAGSLDRSRNLEEAAAAEQGGGCDQVDSSPVPRYRVN
AKKLTPLLPPPLTDMDSTLDSSTGSLLKTNNHIGGGAFSVDSPRIYSNSLPPSAAVAASSSLRINHANHTGSNHTYLKNTYNKPKLSEPE
EELLQQFKREEVSPTGSFSAHYLSMFLLTAACLFFLILGLTYLGMRGTGVSEDGELSIENPFGETFGKIQESEKTLMMNTLYKLHDRLAQ
LAGDHECGSSSQRTLSVQEAAAYLKFIAFASLFFILVSITTFCLETHEAFNIVKNKTEPVINGTSVVLQYEIETDPALTYVEGVCVVWFT
FEFLVRIVFSPNKLEFIKNLLNIIDFVAILPFYLEVGLSGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLL
LIIFLALGVLIFATMIYYAERVGAQPNDPSASEHTQFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTIAMPVPVIVN
NFGMYYSLAMAKQKLPRKRKKHIPPAPQASSPTFCKTELNMACNSTQSDTCLGKDNRLLEHNRSVLSGDDSTGSEPPLSPPERLPIRRSS

--------------------------------------------------------------

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Fusion Gene PPI Analysis for LEMD3-KCNC2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneLEMD3chr12:65612399chr12:75445097ENST00000308330+413699_911565.0912.0SMAD1%2C SMAD2%2C SMAD3 and SMAD5


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for LEMD3-KCNC2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for LEMD3-KCNC2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource