FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:LEPROT-SGIP1 (FusionGDB2 ID:44477)

Fusion Gene Summary for LEPROT-SGIP1

check button Fusion gene summary
Fusion gene informationFusion gene name: LEPROT-SGIP1
Fusion gene ID: 44477
HgeneTgene
Gene symbol

LEPROT

SGIP1

Gene ID

54741

84251

Gene nameleptin receptor overlapping transcriptSH3GL interacting endocytic adaptor 1
SynonymsLEPR|OB-RGRP|OBRGRP|VPS55-
Cytomap

1p31.3

1p31.3

Type of geneprotein-codingprotein-coding
Descriptionleptin receptor gene-related proteinDnaJ (Hsp40) homolog, subfamily C, member 6OB-R gene-related proteinendospaninendospanin-1leptin receptor overlapping transcript proteinSH3-containing GRB2-like protein 3-interacting protein 1SH3 domain GRB2 like endophilin interacting protein 1endophilin-3-interacting protein
Modification date2020032020200313
UniProtAcc

O15243

.
Ensembl transtripts involved in fusion geneENST00000484243, ENST00000371065, 
ENST00000237247, ENST00000371035, 
ENST00000371039, ENST00000371036, 
ENST00000371037, ENST00000435165, 
ENST00000468286, 
Fusion gene scores* DoF score5 X 2 X 4=407 X 7 X 3=147
# samples 68
** MAII scorelog2(6/40*10)=0.584962500721156
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(8/147*10)=-0.877744249949002
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: LEPROT [Title/Abstract] AND SGIP1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointLEPROT(65886423)-SGIP1(67184976), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneLEPROT

GO:0046426

negative regulation of JAK-STAT cascade

18042720

HgeneLEPROT

GO:0060400

negative regulation of growth hormone receptor signaling pathway

19907080

HgeneLEPROT

GO:2000009

negative regulation of protein localization to cell surface

18042720


check buttonFusion gene breakpoints across LEPROT (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SGIP1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-HC-7737-01ALEPROTchr1

65886423

+SGIP1chr1

67184977

+
ChimerDB4PRADTCGA-HC-7737LEPROTchr1

65886423

+SGIP1chr1

67184976

+


Top

Fusion Gene ORF analysis for LEPROT-SGIP1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000484243ENST00000237247LEPROTchr1

65886423

+SGIP1chr1

67184977

+
3UTR-3CDSENST00000484243ENST00000237247LEPROTchr1

65886423

+SGIP1chr1

67184976

+
3UTR-3CDSENST00000484243ENST00000371035LEPROTchr1

65886423

+SGIP1chr1

67184977

+
3UTR-3CDSENST00000484243ENST00000371035LEPROTchr1

65886423

+SGIP1chr1

67184976

+
3UTR-3CDSENST00000484243ENST00000371039LEPROTchr1

65886423

+SGIP1chr1

67184977

+
3UTR-3CDSENST00000484243ENST00000371039LEPROTchr1

65886423

+SGIP1chr1

67184976

+
3UTR-intronENST00000484243ENST00000371036LEPROTchr1

65886423

+SGIP1chr1

67184977

+
3UTR-intronENST00000484243ENST00000371036LEPROTchr1

65886423

+SGIP1chr1

67184976

+
3UTR-intronENST00000484243ENST00000371037LEPROTchr1

65886423

+SGIP1chr1

67184977

+
3UTR-intronENST00000484243ENST00000371037LEPROTchr1

65886423

+SGIP1chr1

67184976

+
3UTR-intronENST00000484243ENST00000435165LEPROTchr1

65886423

+SGIP1chr1

67184977

+
3UTR-intronENST00000484243ENST00000435165LEPROTchr1

65886423

+SGIP1chr1

67184976

+
3UTR-intronENST00000484243ENST00000468286LEPROTchr1

65886423

+SGIP1chr1

67184977

+
3UTR-intronENST00000484243ENST00000468286LEPROTchr1

65886423

+SGIP1chr1

67184976

+
5CDS-intronENST00000371065ENST00000371036LEPROTchr1

65886423

+SGIP1chr1

67184977

+
5CDS-intronENST00000371065ENST00000371036LEPROTchr1

65886423

+SGIP1chr1

67184976

+
5CDS-intronENST00000371065ENST00000371037LEPROTchr1

65886423

+SGIP1chr1

67184977

+
5CDS-intronENST00000371065ENST00000371037LEPROTchr1

65886423

+SGIP1chr1

67184976

+
5CDS-intronENST00000371065ENST00000435165LEPROTchr1

65886423

+SGIP1chr1

67184977

+
5CDS-intronENST00000371065ENST00000435165LEPROTchr1

65886423

+SGIP1chr1

67184976

+
5CDS-intronENST00000371065ENST00000468286LEPROTchr1

65886423

+SGIP1chr1

67184977

+
5CDS-intronENST00000371065ENST00000468286LEPROTchr1

65886423

+SGIP1chr1

67184976

+
In-frameENST00000371065ENST00000237247LEPROTchr1

65886423

+SGIP1chr1

67184977

+
In-frameENST00000371065ENST00000237247LEPROTchr1

65886423

+SGIP1chr1

67184976

+
In-frameENST00000371065ENST00000371035LEPROTchr1

65886423

+SGIP1chr1

67184977

+
In-frameENST00000371065ENST00000371035LEPROTchr1

65886423

+SGIP1chr1

67184976

+
In-frameENST00000371065ENST00000371039LEPROTchr1

65886423

+SGIP1chr1

67184977

+
In-frameENST00000371065ENST00000371039LEPROTchr1

65886423

+SGIP1chr1

67184976

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000371065LEPROTchr165886423+ENST00000237247SGIP1chr167184977+229015431010335
ENST00000371065LEPROTchr165886423+ENST00000371039SGIP1chr167184977+300115431010335
ENST00000371065LEPROTchr165886423+ENST00000371035SGIP1chr167184977+111515431010335
ENST00000371065LEPROTchr165886423+ENST00000237247SGIP1chr167184976+229015431010335
ENST00000371065LEPROTchr165886423+ENST00000371039SGIP1chr167184976+300115431010335
ENST00000371065LEPROTchr165886423+ENST00000371035SGIP1chr167184976+111515431010335

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000371065ENST00000237247LEPROTchr165886423+SGIP1chr167184977+0.0004161660.9995838
ENST00000371065ENST00000371039LEPROTchr165886423+SGIP1chr167184977+0.0003277950.9996722
ENST00000371065ENST00000371035LEPROTchr165886423+SGIP1chr167184977+0.0020912010.99790883
ENST00000371065ENST00000237247LEPROTchr165886423+SGIP1chr167184976+0.0004161660.9995838
ENST00000371065ENST00000371039LEPROTchr165886423+SGIP1chr167184976+0.0003277950.9996722
ENST00000371065ENST00000371035LEPROTchr165886423+SGIP1chr167184976+0.0020912010.99790883

Top

Fusion Genomic Features for LEPROT-SGIP1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
LEPROTchr165886423+SGIP1chr167184976+2.61E-050.9999739
LEPROTchr165886423+SGIP1chr167184976+2.61E-050.9999739
LEPROTchr165886423+SGIP1chr167184976+2.61E-050.9999739
LEPROTchr165886423+SGIP1chr167184976+2.61E-050.9999739

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for LEPROT-SGIP1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:65886423/chr1:67184976)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LEPROT

O15243

.
FUNCTION: Negatively regulates leptin receptor (LEPR) cell surface expression, and thus decreases response to leptin. Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver resistance to GH during periods of reduced nutrient availability. {ECO:0000269|PubMed:18042720, ECO:0000269|PubMed:19907080}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSGIP1chr1:65886423chr1:67184976ENST000003710371725559_827543829.0DomainMHD
TgeneSGIP1chr1:65886423chr1:67184976ENST000003710391422559_827346632.0DomainMHD
TgeneSGIP1chr1:65886423chr1:67184977ENST000003710371725559_827543829.0DomainMHD
TgeneSGIP1chr1:65886423chr1:67184977ENST000003710391422559_827346632.0DomainMHD

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLEPROTchr1:65886423chr1:67184976ENST00000371065+14100_1205132.0TransmembraneHelical
HgeneLEPROTchr1:65886423chr1:67184976ENST00000371065+1432_525132.0TransmembraneHelical
HgeneLEPROTchr1:65886423chr1:67184976ENST00000371065+1469_895132.0TransmembraneHelical
HgeneLEPROTchr1:65886423chr1:67184976ENST00000371065+147_275132.0TransmembraneHelical
HgeneLEPROTchr1:65886423chr1:67184977ENST00000371065+14100_1205132.0TransmembraneHelical
HgeneLEPROTchr1:65886423chr1:67184977ENST00000371065+1432_525132.0TransmembraneHelical
HgeneLEPROTchr1:65886423chr1:67184977ENST00000371065+1469_895132.0TransmembraneHelical
HgeneLEPROTchr1:65886423chr1:67184977ENST00000371065+147_275132.0TransmembraneHelical
TgeneSGIP1chr1:65886423chr1:67184976ENST000002372471927106_112574860.0Compositional biasPoly-Glu
TgeneSGIP1chr1:65886423chr1:67184976ENST000002372471927176_499574860.0Compositional biasPro-rich
TgeneSGIP1chr1:65886423chr1:67184976ENST000003710371725106_112543829.0Compositional biasPoly-Glu
TgeneSGIP1chr1:65886423chr1:67184976ENST000003710371725176_499543829.0Compositional biasPro-rich
TgeneSGIP1chr1:65886423chr1:67184976ENST000003710391422106_112346632.0Compositional biasPoly-Glu
TgeneSGIP1chr1:65886423chr1:67184976ENST000003710391422176_499346632.0Compositional biasPro-rich
TgeneSGIP1chr1:65886423chr1:67184977ENST000002372471927106_112574860.0Compositional biasPoly-Glu
TgeneSGIP1chr1:65886423chr1:67184977ENST000002372471927176_499574860.0Compositional biasPro-rich
TgeneSGIP1chr1:65886423chr1:67184977ENST000003710371725106_112543829.0Compositional biasPoly-Glu
TgeneSGIP1chr1:65886423chr1:67184977ENST000003710371725176_499543829.0Compositional biasPro-rich
TgeneSGIP1chr1:65886423chr1:67184977ENST000003710391422106_112346632.0Compositional biasPoly-Glu
TgeneSGIP1chr1:65886423chr1:67184977ENST000003710391422176_499346632.0Compositional biasPro-rich
TgeneSGIP1chr1:65886423chr1:67184976ENST000002372471927559_827574860.0DomainMHD
TgeneSGIP1chr1:65886423chr1:67184977ENST000002372471927559_827574860.0DomainMHD


Top

Fusion Gene Sequence for LEPROT-SGIP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>44477_44477_1_LEPROT-SGIP1_LEPROT_chr1_65886423_ENST00000371065_SGIP1_chr1_67184976_ENST00000237247_length(transcript)=2290nt_BP=154nt
GTTCTGCACCGGCGGGGGCGGGGCTCTGCGTGGCCGGGGCGGGCTCGGGATCCGCGGGGCGACTCCCGGTCTGGCTTGGGCAGGCTGCCC
GGGCCGTGGCAGGAAGCCGGAAGCAGCCGCGGCCCCAGTTCGGGAGACATGGCGGGCGTTAAAGGTTCTTCCAGGGGACCCAGCCCCCTA
ACCATGGGAGCTCAGGACACTCTCCCTGTTGCAGCAGCATTTACAGAAACAGTCAATGCCTATTTCAAAGGAGCAGACCCAAGCAAATGT
ATCGTTAAGATTACCGGAGAAATGGTGTTGTCATTTCCTGCTGGCATCACCAGACACTTTGCCAACAACCCGTCCCCAGCTGCTCTGACT
TTTCGGGTGATAAATTTCAGCAGGTTAGAACACGTCCTGCCAAACCCCCAACTTCTCTGCTGTGATAATACACAAAATGATGCCAATACC
AAGGAATTCTGGGTAAACATGCCAAATTTGATGACTCACCTAAAGAAAGTGTCTGAACAAAAACCCCAGGCTACATATTATAACGTTGAC
ATGCTCAAATATCAGGTGTCTGCCCAGGGCATTCAGTCCACACCTCTGAACCTGGCAGTGAATTGGCGATGTGAGCCTTCAAGCACTGAC
CTGCGCATAGATTACAAATATAATACAGATGCAATGACGACTGCTGTGGCCCTCAACAATGTGCAGTTCCTGGTCCCCATCGACGGAGGA
GTCACCAAGCTCCAGGCAGTGCTCCCACCAGCAGTCTGGAATGCTGAACAACAGAGAATATTGTGGAAGATTCCTGATATCTCTCAGAAG
TCAGAAAATGGAGGGGTGGGTTCTTTGTTGGCAAGATTTCAGTTATCTGAAGGCCCAAGCAAACCTTCTCCATTGGTTGTGCAGTTCACA
AGTGAAGGAAGCACCCTTTCTGGCTGTGACATTGAACTTGTTGGAGCAGGGTATCGATTTTCACTCATCAAGAAAAGGTTTGCTGCAGGA
AAATACTTGGCAGATAACTAATGAAATCTTATGCAAGGATTTGGAGGATTCATATAATGGAGAACTGATGTATGAGAAACAGATTTTAAT
TTTGGTTTGATGAAAACAAACCAATATCTGCACTTGGGATATATCAGGTGGAAAGTCAATGACTTTCATCTGTGATTTCCCTCACACACT
ACCATGATGACCAGTCCTACAGTATTTACTTCTAGGTGTAATATTGTTAATGGTTTTAAAATGTAATTATTGTATTTGTAAATTGTACTC
TCATTCCAGTAAGGCAGTTAGACACTTGAGTTTTAGCATTTTACCATTCCTGAAATGGATGTAATTTAAACTGTGGTATGTAAATTTAAT
AGTAGTATTGTTGAATGGCACAATGCTTACAGAGGTAGATTGCATTTTGTCAATATATAAAATTTAAATATAATATTGATAGCTGTCATA
AAGGGGGTGCCACATATTAAAGAAACTTAAGTGGAACCAGAAGAAAAAGAAACAAACTTACTTTTCTTCAATGCTTAGTATGTTTTACTC
TAGTGCTAAATAAAAACTCTATCTTCAAATGTTTAGTGGGTTAAATTGAGAAACTATTTCAGAAAAAAATTCTAAGGTTACAGCATATTC
AAAGAAAAGCATTAGTTACCACTTTTTAAAAAGCTTTTTTTTCAAACTGCAAATTTCATAAAAATGCAAACTGTGTAAACAGGGCCTCTT
ATTTTTATAACTTGTGTAAAAAGGGAAAGCAATTCATATTTAAAGTTTAAGTATATTAAATTATAATCAAGAGTAAAGAAGATGTTGAAG
TCTTAACTACTTGCCCCTCTCTACAGTTTCGCAAATGTGGGGATTGCTGAATAATCAGTCAGACTAAAACCAAAATTGTGATTTTAAGAT
TTCAAGACTTTCCGTAGTTGAACTGGTTAAGAATTTTTGCTTAGTTACTCTGAATAGATGATCTTACTCATCCAGTATGGGGGAATGATA
CCTCACGTCTTCCTCTTTACCCACAGGAATCAAAACGCTGAGACTGAGAATTTTAGGGAAAAAAAAGTCCACTGTTTAGATCCAGAAGGA
GAGTTTTAATCATTGTTTATATCATTTGAGAATGAAAAAATAAGCTTCATAAATGAAATTCTATTCACATTACTGTGTAATAAATTTCCT
TTTGGATGATTAGGATTCATTGTATAAAACTGTAAATCTTTGCCATTCTTGGAGAAGCAAAAGGAGAGTTATCAAAAATGTATGTCGTTT

>44477_44477_1_LEPROT-SGIP1_LEPROT_chr1_65886423_ENST00000371065_SGIP1_chr1_67184976_ENST00000237247_length(amino acids)=335AA_BP=50
MHRRGRGSAWPGRARDPRGDSRSGLGRLPGPWQEAGSSRGPSSGDMAGVKGSSRGPSPLTMGAQDTLPVAAAFTETVNAYFKGADPSKCI
VKITGEMVLSFPAGITRHFANNPSPAALTFRVINFSRLEHVLPNPQLLCCDNTQNDANTKEFWVNMPNLMTHLKKVSEQKPQATYYNVDM
LKYQVSAQGIQSTPLNLAVNWRCEPSSTDLRIDYKYNTDAMTTAVALNNVQFLVPIDGGVTKLQAVLPPAVWNAEQQRILWKIPDISQKS

--------------------------------------------------------------
>44477_44477_2_LEPROT-SGIP1_LEPROT_chr1_65886423_ENST00000371065_SGIP1_chr1_67184976_ENST00000371035_length(transcript)=1115nt_BP=154nt
GTTCTGCACCGGCGGGGGCGGGGCTCTGCGTGGCCGGGGCGGGCTCGGGATCCGCGGGGCGACTCCCGGTCTGGCTTGGGCAGGCTGCCC
GGGCCGTGGCAGGAAGCCGGAAGCAGCCGCGGCCCCAGTTCGGGAGACATGGCGGGCGTTAAAGGTTCTTCCAGGGGACCCAGCCCCCTA
ACCATGGGAGCTCAGGACACTCTCCCTGTTGCAGCAGCATTTACAGAAACAGTCAATGCCTATTTCAAAGGAGCAGACCCAAGCAAATGT
ATCGTTAAGATTACCGGAGAAATGGTGTTGTCATTTCCTGCTGGCATCACCAGACACTTTGCCAACAACCCGTCCCCAGCTGCTCTGACT
TTTCGGGTGATAAATTTCAGCAGGTTAGAACACGTCCTGCCAAACCCCCAACTTCTCTGCTGTGATAATACACAAAATGATGCCAATACC
AAGGAATTCTGGGTAAACATGCCAAATTTGATGACTCACCTAAAGAAAGTGTCTGAACAAAAACCCCAGGCTACATATTATAACGTTGAC
ATGCTCAAATATCAGGTGTCTGCCCAGGGCATTCAGTCCACACCTCTGAACCTGGCAGTGAATTGGCGATGTGAGCCTTCAAGCACTGAC
CTGCGCATAGATTACAAATATAATACAGATGCAATGACGACTGCTGTGGCCCTCAACAATGTGCAGTTCCTGGTCCCCATCGACGGAGGA
GTCACCAAGCTCCAGGCAGTGCTCCCACCAGCAGTCTGGAATGCTGAACAACAGAGAATATTGTGGAAGATTCCTGATATCTCTCAGAAG
TCAGAAAATGGAGGGGTGGGTTCTTTGTTGGCAAGATTTCAGTTATCTGAAGGCCCAAGCAAACCTTCTCCATTGGTTGTGCAGTTCACA
AGTGAAGGAAGCACCCTTTCTGGCTGTGACATTGAACTTGTTGGAGCAGGGTATCGATTTTCACTCATCAAGAAAAGGTTTGCTGCAGGA
AAATACTTGGCAGATAACTAATGAAATCTTATGCAAGGATTTGGAGGATTCATATAATGGAGAACTGATGTATGAGAAACAGATTTTAAT

>44477_44477_2_LEPROT-SGIP1_LEPROT_chr1_65886423_ENST00000371065_SGIP1_chr1_67184976_ENST00000371035_length(amino acids)=335AA_BP=50
MHRRGRGSAWPGRARDPRGDSRSGLGRLPGPWQEAGSSRGPSSGDMAGVKGSSRGPSPLTMGAQDTLPVAAAFTETVNAYFKGADPSKCI
VKITGEMVLSFPAGITRHFANNPSPAALTFRVINFSRLEHVLPNPQLLCCDNTQNDANTKEFWVNMPNLMTHLKKVSEQKPQATYYNVDM
LKYQVSAQGIQSTPLNLAVNWRCEPSSTDLRIDYKYNTDAMTTAVALNNVQFLVPIDGGVTKLQAVLPPAVWNAEQQRILWKIPDISQKS

--------------------------------------------------------------
>44477_44477_3_LEPROT-SGIP1_LEPROT_chr1_65886423_ENST00000371065_SGIP1_chr1_67184976_ENST00000371039_length(transcript)=3001nt_BP=154nt
GTTCTGCACCGGCGGGGGCGGGGCTCTGCGTGGCCGGGGCGGGCTCGGGATCCGCGGGGCGACTCCCGGTCTGGCTTGGGCAGGCTGCCC
GGGCCGTGGCAGGAAGCCGGAAGCAGCCGCGGCCCCAGTTCGGGAGACATGGCGGGCGTTAAAGGTTCTTCCAGGGGACCCAGCCCCCTA
ACCATGGGAGCTCAGGACACTCTCCCTGTTGCAGCAGCATTTACAGAAACAGTCAATGCCTATTTCAAAGGAGCAGACCCAAGCAAATGT
ATCGTTAAGATTACCGGAGAAATGGTGTTGTCATTTCCTGCTGGCATCACCAGACACTTTGCCAACAACCCGTCCCCAGCTGCTCTGACT
TTTCGGGTGATAAATTTCAGCAGGTTAGAACACGTCCTGCCAAACCCCCAACTTCTCTGCTGTGATAATACACAAAATGATGCCAATACC
AAGGAATTCTGGGTAAACATGCCAAATTTGATGACTCACCTAAAGAAAGTGTCTGAACAAAAACCCCAGGCTACATATTATAACGTTGAC
ATGCTCAAATATCAGGTGTCTGCCCAGGGCATTCAGTCCACACCTCTGAACCTGGCAGTGAATTGGCGATGTGAGCCTTCAAGCACTGAC
CTGCGCATAGATTACAAATATAATACAGATGCAATGACGACTGCTGTGGCCCTCAACAATGTGCAGTTCCTGGTCCCCATCGACGGAGGA
GTCACCAAGCTCCAGGCAGTGCTCCCACCAGCAGTCTGGAATGCTGAACAACAGAGAATATTGTGGAAGATTCCTGATATCTCTCAGAAG
TCAGAAAATGGAGGGGTGGGTTCTTTGTTGGCAAGATTTCAGTTATCTGAAGGCCCAAGCAAACCTTCTCCATTGGTTGTGCAGTTCACA
AGTGAAGGAAGCACCCTTTCTGGCTGTGACATTGAACTTGTTGGAGCAGGGTATCGATTTTCACTCATCAAGAAAAGGTTTGCTGCAGGA
AAATACTTGGCAGATAACTAATGAAATCTTATGCAAGGATTTGGAGGATTCATATAATGGAGAACTGATGTATGAGAAACAGATTTTAAT
TTTGGTTTGATGAAAACAAACCAATATCTGCACTTGGGATATATCAGGTGGAAAGTCAATGACTTTCATCTGTGATTTCCCTCACACACT
ACCATGATGACCAGTCCTACAGTATTTACTTCTAGGTGTAATATTGTTAATGGTTTTAAAATGTAATTATTGTATTTGTAAATTGTACTC
TCATTCCAGTAAGGCAGTTAGACACTTGAGTTTTAGCATTTTACCATTCCTGAAATGGATGTAATTTAAACTGTGGTATGTAAATTTAAT
AGTAGTATTGTTGAATGGCACAATGCTTACAGAGGTAGATTGCATTTTGTCAATATATAAAATTTAAATATAATATTGATAGCTGTCATA
AAGGGGGTGCCACATATTAAAGAAACTTAAGTGGAACCAGAAGAAAAAGAAACAAACTTACTTTTCTTCAATGCTTAGTATGTTTTACTC
TAGTGCTAAATAAAAACTCTATCTTCAAATGTTTAGTGGGTTAAATTGAGAAACTATTTCAGAAAAAAATTCTAAGGTTACAGCATATTC
AAAGAAAAGCATTAGTTACCACTTTTTAAAAAGCTTTTTTTTCAAACTGCAAATTTCATAAAAATGCAAACTGTGTAAACAGGGCCTCTT
ATTTTTATAACTTGTGTAAAAAGGGAAAGCAATTCATATTTAAAGTTTAAGTATATTAAATTATAATCAAGAGTAAAGAAGATGTTGAAG
TCTTAACTACTTGCCCCTCTCTACAGTTTCGCAAATGTGGGGATTGCTGAATAATCAGTCAGACTAAAACCAAAATTGTGATTTTAAGAT
TTCAAGACTTTCCGTAGTTGAACTGGTTAAGAATTTTTGCTTAGTTACTCTGAATAGATGATCTTACTCATCCAGTATGGGGGAATGATA
CCTCACGTCTTCCTCTTTACCCACAGGAATCAAAACGCTGAGACTGAGAATTTTAGGGAAAAAAAAGTCCACTGTTTAGATCCAGAAGGA
GAGTTTTAATCATTGTTTATATCATTTGAGAATGAAAAAATAAGCTTCATAAATGAAATTCTATTCACATTACTGTGTAATAAATTTCCT
TTTGGATGATTAGGATTCATTGTATAAAACTGTAAATCTTTGCCATTCTTGGAGAAGCAAAAGGAGAGTTATCAAAAATGTATGTCGTTT
CATCGTTGCAAGGTATAATAAAAACTGTAATTATTCAATCTGGCCCTGCCATATGAACATTTAGAAAGACAAACTTCTTCGGGAGTCTCA
GTTGTAAAACCTTCCCTCATTAATATCTGAAAATGTTAGTCTTCCTTTAAGTCATAGAACTTATTTAAACATAAACCAATTTCTATTACA
GGTTATGCTATTAAATAGCTGTAATTATTAAGTTATTATTTTTATAATTAGTTGTTAAATTTCATTTTACACCCACTCAAATTTAACAAA
GAATCTTTAGCCCCTTTAAATTTTAGAATTAAATTAAATTTTTAAAGTTTTACTTCTAAAATGAGATTGTGACTGGCAATTGTTTATAGT
GAAACTTTTTAAATTAATCTTTGTACTCCTCTATCAGTGCTTGCTACCAAGAGAATGTCCAAAATGATTTGTTTTACCATGGGAAAATTC
TTACTATTCAACAAACTCTCAGTTGGCCCCCTACAGCAGTCTGGTGTTGAAGTTTCTTTGAACGAACTAAATATACTCATTTTATGTAAA
GGTATCCAATTTGATTTTGAAACCAAAATAGAAAATGCAAAATTCTAAATTCCATGAAACATGGAATTTATGACACCAAAATCAATGGAG
AGTAAGCAGCAGCAAACTGAGAATTATCCAGCATATGAATATAACAATGTGTTTTTAAGTAATCAATTCATTTAAAAAATTGAATATTAA

>44477_44477_3_LEPROT-SGIP1_LEPROT_chr1_65886423_ENST00000371065_SGIP1_chr1_67184976_ENST00000371039_length(amino acids)=335AA_BP=50
MHRRGRGSAWPGRARDPRGDSRSGLGRLPGPWQEAGSSRGPSSGDMAGVKGSSRGPSPLTMGAQDTLPVAAAFTETVNAYFKGADPSKCI
VKITGEMVLSFPAGITRHFANNPSPAALTFRVINFSRLEHVLPNPQLLCCDNTQNDANTKEFWVNMPNLMTHLKKVSEQKPQATYYNVDM
LKYQVSAQGIQSTPLNLAVNWRCEPSSTDLRIDYKYNTDAMTTAVALNNVQFLVPIDGGVTKLQAVLPPAVWNAEQQRILWKIPDISQKS

--------------------------------------------------------------
>44477_44477_4_LEPROT-SGIP1_LEPROT_chr1_65886423_ENST00000371065_SGIP1_chr1_67184977_ENST00000237247_length(transcript)=2290nt_BP=154nt
GTTCTGCACCGGCGGGGGCGGGGCTCTGCGTGGCCGGGGCGGGCTCGGGATCCGCGGGGCGACTCCCGGTCTGGCTTGGGCAGGCTGCCC
GGGCCGTGGCAGGAAGCCGGAAGCAGCCGCGGCCCCAGTTCGGGAGACATGGCGGGCGTTAAAGGTTCTTCCAGGGGACCCAGCCCCCTA
ACCATGGGAGCTCAGGACACTCTCCCTGTTGCAGCAGCATTTACAGAAACAGTCAATGCCTATTTCAAAGGAGCAGACCCAAGCAAATGT
ATCGTTAAGATTACCGGAGAAATGGTGTTGTCATTTCCTGCTGGCATCACCAGACACTTTGCCAACAACCCGTCCCCAGCTGCTCTGACT
TTTCGGGTGATAAATTTCAGCAGGTTAGAACACGTCCTGCCAAACCCCCAACTTCTCTGCTGTGATAATACACAAAATGATGCCAATACC
AAGGAATTCTGGGTAAACATGCCAAATTTGATGACTCACCTAAAGAAAGTGTCTGAACAAAAACCCCAGGCTACATATTATAACGTTGAC
ATGCTCAAATATCAGGTGTCTGCCCAGGGCATTCAGTCCACACCTCTGAACCTGGCAGTGAATTGGCGATGTGAGCCTTCAAGCACTGAC
CTGCGCATAGATTACAAATATAATACAGATGCAATGACGACTGCTGTGGCCCTCAACAATGTGCAGTTCCTGGTCCCCATCGACGGAGGA
GTCACCAAGCTCCAGGCAGTGCTCCCACCAGCAGTCTGGAATGCTGAACAACAGAGAATATTGTGGAAGATTCCTGATATCTCTCAGAAG
TCAGAAAATGGAGGGGTGGGTTCTTTGTTGGCAAGATTTCAGTTATCTGAAGGCCCAAGCAAACCTTCTCCATTGGTTGTGCAGTTCACA
AGTGAAGGAAGCACCCTTTCTGGCTGTGACATTGAACTTGTTGGAGCAGGGTATCGATTTTCACTCATCAAGAAAAGGTTTGCTGCAGGA
AAATACTTGGCAGATAACTAATGAAATCTTATGCAAGGATTTGGAGGATTCATATAATGGAGAACTGATGTATGAGAAACAGATTTTAAT
TTTGGTTTGATGAAAACAAACCAATATCTGCACTTGGGATATATCAGGTGGAAAGTCAATGACTTTCATCTGTGATTTCCCTCACACACT
ACCATGATGACCAGTCCTACAGTATTTACTTCTAGGTGTAATATTGTTAATGGTTTTAAAATGTAATTATTGTATTTGTAAATTGTACTC
TCATTCCAGTAAGGCAGTTAGACACTTGAGTTTTAGCATTTTACCATTCCTGAAATGGATGTAATTTAAACTGTGGTATGTAAATTTAAT
AGTAGTATTGTTGAATGGCACAATGCTTACAGAGGTAGATTGCATTTTGTCAATATATAAAATTTAAATATAATATTGATAGCTGTCATA
AAGGGGGTGCCACATATTAAAGAAACTTAAGTGGAACCAGAAGAAAAAGAAACAAACTTACTTTTCTTCAATGCTTAGTATGTTTTACTC
TAGTGCTAAATAAAAACTCTATCTTCAAATGTTTAGTGGGTTAAATTGAGAAACTATTTCAGAAAAAAATTCTAAGGTTACAGCATATTC
AAAGAAAAGCATTAGTTACCACTTTTTAAAAAGCTTTTTTTTCAAACTGCAAATTTCATAAAAATGCAAACTGTGTAAACAGGGCCTCTT
ATTTTTATAACTTGTGTAAAAAGGGAAAGCAATTCATATTTAAAGTTTAAGTATATTAAATTATAATCAAGAGTAAAGAAGATGTTGAAG
TCTTAACTACTTGCCCCTCTCTACAGTTTCGCAAATGTGGGGATTGCTGAATAATCAGTCAGACTAAAACCAAAATTGTGATTTTAAGAT
TTCAAGACTTTCCGTAGTTGAACTGGTTAAGAATTTTTGCTTAGTTACTCTGAATAGATGATCTTACTCATCCAGTATGGGGGAATGATA
CCTCACGTCTTCCTCTTTACCCACAGGAATCAAAACGCTGAGACTGAGAATTTTAGGGAAAAAAAAGTCCACTGTTTAGATCCAGAAGGA
GAGTTTTAATCATTGTTTATATCATTTGAGAATGAAAAAATAAGCTTCATAAATGAAATTCTATTCACATTACTGTGTAATAAATTTCCT
TTTGGATGATTAGGATTCATTGTATAAAACTGTAAATCTTTGCCATTCTTGGAGAAGCAAAAGGAGAGTTATCAAAAATGTATGTCGTTT

>44477_44477_4_LEPROT-SGIP1_LEPROT_chr1_65886423_ENST00000371065_SGIP1_chr1_67184977_ENST00000237247_length(amino acids)=335AA_BP=50
MHRRGRGSAWPGRARDPRGDSRSGLGRLPGPWQEAGSSRGPSSGDMAGVKGSSRGPSPLTMGAQDTLPVAAAFTETVNAYFKGADPSKCI
VKITGEMVLSFPAGITRHFANNPSPAALTFRVINFSRLEHVLPNPQLLCCDNTQNDANTKEFWVNMPNLMTHLKKVSEQKPQATYYNVDM
LKYQVSAQGIQSTPLNLAVNWRCEPSSTDLRIDYKYNTDAMTTAVALNNVQFLVPIDGGVTKLQAVLPPAVWNAEQQRILWKIPDISQKS

--------------------------------------------------------------
>44477_44477_5_LEPROT-SGIP1_LEPROT_chr1_65886423_ENST00000371065_SGIP1_chr1_67184977_ENST00000371035_length(transcript)=1115nt_BP=154nt
GTTCTGCACCGGCGGGGGCGGGGCTCTGCGTGGCCGGGGCGGGCTCGGGATCCGCGGGGCGACTCCCGGTCTGGCTTGGGCAGGCTGCCC
GGGCCGTGGCAGGAAGCCGGAAGCAGCCGCGGCCCCAGTTCGGGAGACATGGCGGGCGTTAAAGGTTCTTCCAGGGGACCCAGCCCCCTA
ACCATGGGAGCTCAGGACACTCTCCCTGTTGCAGCAGCATTTACAGAAACAGTCAATGCCTATTTCAAAGGAGCAGACCCAAGCAAATGT
ATCGTTAAGATTACCGGAGAAATGGTGTTGTCATTTCCTGCTGGCATCACCAGACACTTTGCCAACAACCCGTCCCCAGCTGCTCTGACT
TTTCGGGTGATAAATTTCAGCAGGTTAGAACACGTCCTGCCAAACCCCCAACTTCTCTGCTGTGATAATACACAAAATGATGCCAATACC
AAGGAATTCTGGGTAAACATGCCAAATTTGATGACTCACCTAAAGAAAGTGTCTGAACAAAAACCCCAGGCTACATATTATAACGTTGAC
ATGCTCAAATATCAGGTGTCTGCCCAGGGCATTCAGTCCACACCTCTGAACCTGGCAGTGAATTGGCGATGTGAGCCTTCAAGCACTGAC
CTGCGCATAGATTACAAATATAATACAGATGCAATGACGACTGCTGTGGCCCTCAACAATGTGCAGTTCCTGGTCCCCATCGACGGAGGA
GTCACCAAGCTCCAGGCAGTGCTCCCACCAGCAGTCTGGAATGCTGAACAACAGAGAATATTGTGGAAGATTCCTGATATCTCTCAGAAG
TCAGAAAATGGAGGGGTGGGTTCTTTGTTGGCAAGATTTCAGTTATCTGAAGGCCCAAGCAAACCTTCTCCATTGGTTGTGCAGTTCACA
AGTGAAGGAAGCACCCTTTCTGGCTGTGACATTGAACTTGTTGGAGCAGGGTATCGATTTTCACTCATCAAGAAAAGGTTTGCTGCAGGA
AAATACTTGGCAGATAACTAATGAAATCTTATGCAAGGATTTGGAGGATTCATATAATGGAGAACTGATGTATGAGAAACAGATTTTAAT

>44477_44477_5_LEPROT-SGIP1_LEPROT_chr1_65886423_ENST00000371065_SGIP1_chr1_67184977_ENST00000371035_length(amino acids)=335AA_BP=50
MHRRGRGSAWPGRARDPRGDSRSGLGRLPGPWQEAGSSRGPSSGDMAGVKGSSRGPSPLTMGAQDTLPVAAAFTETVNAYFKGADPSKCI
VKITGEMVLSFPAGITRHFANNPSPAALTFRVINFSRLEHVLPNPQLLCCDNTQNDANTKEFWVNMPNLMTHLKKVSEQKPQATYYNVDM
LKYQVSAQGIQSTPLNLAVNWRCEPSSTDLRIDYKYNTDAMTTAVALNNVQFLVPIDGGVTKLQAVLPPAVWNAEQQRILWKIPDISQKS

--------------------------------------------------------------
>44477_44477_6_LEPROT-SGIP1_LEPROT_chr1_65886423_ENST00000371065_SGIP1_chr1_67184977_ENST00000371039_length(transcript)=3001nt_BP=154nt
GTTCTGCACCGGCGGGGGCGGGGCTCTGCGTGGCCGGGGCGGGCTCGGGATCCGCGGGGCGACTCCCGGTCTGGCTTGGGCAGGCTGCCC
GGGCCGTGGCAGGAAGCCGGAAGCAGCCGCGGCCCCAGTTCGGGAGACATGGCGGGCGTTAAAGGTTCTTCCAGGGGACCCAGCCCCCTA
ACCATGGGAGCTCAGGACACTCTCCCTGTTGCAGCAGCATTTACAGAAACAGTCAATGCCTATTTCAAAGGAGCAGACCCAAGCAAATGT
ATCGTTAAGATTACCGGAGAAATGGTGTTGTCATTTCCTGCTGGCATCACCAGACACTTTGCCAACAACCCGTCCCCAGCTGCTCTGACT
TTTCGGGTGATAAATTTCAGCAGGTTAGAACACGTCCTGCCAAACCCCCAACTTCTCTGCTGTGATAATACACAAAATGATGCCAATACC
AAGGAATTCTGGGTAAACATGCCAAATTTGATGACTCACCTAAAGAAAGTGTCTGAACAAAAACCCCAGGCTACATATTATAACGTTGAC
ATGCTCAAATATCAGGTGTCTGCCCAGGGCATTCAGTCCACACCTCTGAACCTGGCAGTGAATTGGCGATGTGAGCCTTCAAGCACTGAC
CTGCGCATAGATTACAAATATAATACAGATGCAATGACGACTGCTGTGGCCCTCAACAATGTGCAGTTCCTGGTCCCCATCGACGGAGGA
GTCACCAAGCTCCAGGCAGTGCTCCCACCAGCAGTCTGGAATGCTGAACAACAGAGAATATTGTGGAAGATTCCTGATATCTCTCAGAAG
TCAGAAAATGGAGGGGTGGGTTCTTTGTTGGCAAGATTTCAGTTATCTGAAGGCCCAAGCAAACCTTCTCCATTGGTTGTGCAGTTCACA
AGTGAAGGAAGCACCCTTTCTGGCTGTGACATTGAACTTGTTGGAGCAGGGTATCGATTTTCACTCATCAAGAAAAGGTTTGCTGCAGGA
AAATACTTGGCAGATAACTAATGAAATCTTATGCAAGGATTTGGAGGATTCATATAATGGAGAACTGATGTATGAGAAACAGATTTTAAT
TTTGGTTTGATGAAAACAAACCAATATCTGCACTTGGGATATATCAGGTGGAAAGTCAATGACTTTCATCTGTGATTTCCCTCACACACT
ACCATGATGACCAGTCCTACAGTATTTACTTCTAGGTGTAATATTGTTAATGGTTTTAAAATGTAATTATTGTATTTGTAAATTGTACTC
TCATTCCAGTAAGGCAGTTAGACACTTGAGTTTTAGCATTTTACCATTCCTGAAATGGATGTAATTTAAACTGTGGTATGTAAATTTAAT
AGTAGTATTGTTGAATGGCACAATGCTTACAGAGGTAGATTGCATTTTGTCAATATATAAAATTTAAATATAATATTGATAGCTGTCATA
AAGGGGGTGCCACATATTAAAGAAACTTAAGTGGAACCAGAAGAAAAAGAAACAAACTTACTTTTCTTCAATGCTTAGTATGTTTTACTC
TAGTGCTAAATAAAAACTCTATCTTCAAATGTTTAGTGGGTTAAATTGAGAAACTATTTCAGAAAAAAATTCTAAGGTTACAGCATATTC
AAAGAAAAGCATTAGTTACCACTTTTTAAAAAGCTTTTTTTTCAAACTGCAAATTTCATAAAAATGCAAACTGTGTAAACAGGGCCTCTT
ATTTTTATAACTTGTGTAAAAAGGGAAAGCAATTCATATTTAAAGTTTAAGTATATTAAATTATAATCAAGAGTAAAGAAGATGTTGAAG
TCTTAACTACTTGCCCCTCTCTACAGTTTCGCAAATGTGGGGATTGCTGAATAATCAGTCAGACTAAAACCAAAATTGTGATTTTAAGAT
TTCAAGACTTTCCGTAGTTGAACTGGTTAAGAATTTTTGCTTAGTTACTCTGAATAGATGATCTTACTCATCCAGTATGGGGGAATGATA
CCTCACGTCTTCCTCTTTACCCACAGGAATCAAAACGCTGAGACTGAGAATTTTAGGGAAAAAAAAGTCCACTGTTTAGATCCAGAAGGA
GAGTTTTAATCATTGTTTATATCATTTGAGAATGAAAAAATAAGCTTCATAAATGAAATTCTATTCACATTACTGTGTAATAAATTTCCT
TTTGGATGATTAGGATTCATTGTATAAAACTGTAAATCTTTGCCATTCTTGGAGAAGCAAAAGGAGAGTTATCAAAAATGTATGTCGTTT
CATCGTTGCAAGGTATAATAAAAACTGTAATTATTCAATCTGGCCCTGCCATATGAACATTTAGAAAGACAAACTTCTTCGGGAGTCTCA
GTTGTAAAACCTTCCCTCATTAATATCTGAAAATGTTAGTCTTCCTTTAAGTCATAGAACTTATTTAAACATAAACCAATTTCTATTACA
GGTTATGCTATTAAATAGCTGTAATTATTAAGTTATTATTTTTATAATTAGTTGTTAAATTTCATTTTACACCCACTCAAATTTAACAAA
GAATCTTTAGCCCCTTTAAATTTTAGAATTAAATTAAATTTTTAAAGTTTTACTTCTAAAATGAGATTGTGACTGGCAATTGTTTATAGT
GAAACTTTTTAAATTAATCTTTGTACTCCTCTATCAGTGCTTGCTACCAAGAGAATGTCCAAAATGATTTGTTTTACCATGGGAAAATTC
TTACTATTCAACAAACTCTCAGTTGGCCCCCTACAGCAGTCTGGTGTTGAAGTTTCTTTGAACGAACTAAATATACTCATTTTATGTAAA
GGTATCCAATTTGATTTTGAAACCAAAATAGAAAATGCAAAATTCTAAATTCCATGAAACATGGAATTTATGACACCAAAATCAATGGAG
AGTAAGCAGCAGCAAACTGAGAATTATCCAGCATATGAATATAACAATGTGTTTTTAAGTAATCAATTCATTTAAAAAATTGAATATTAA

>44477_44477_6_LEPROT-SGIP1_LEPROT_chr1_65886423_ENST00000371065_SGIP1_chr1_67184977_ENST00000371039_length(amino acids)=335AA_BP=50
MHRRGRGSAWPGRARDPRGDSRSGLGRLPGPWQEAGSSRGPSSGDMAGVKGSSRGPSPLTMGAQDTLPVAAAFTETVNAYFKGADPSKCI
VKITGEMVLSFPAGITRHFANNPSPAALTFRVINFSRLEHVLPNPQLLCCDNTQNDANTKEFWVNMPNLMTHLKKVSEQKPQATYYNVDM
LKYQVSAQGIQSTPLNLAVNWRCEPSSTDLRIDYKYNTDAMTTAVALNNVQFLVPIDGGVTKLQAVLPPAVWNAEQQRILWKIPDISQKS

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for LEPROT-SGIP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneSGIP1chr1:65886423chr1:67184976ENST000002372471927667_670574.3333333333334860.0DPF motifs-containing proteins
TgeneSGIP1chr1:65886423chr1:67184976ENST000002372471927813_818574.3333333333334860.0DPF motifs-containing proteins
TgeneSGIP1chr1:65886423chr1:67184976ENST000003710371725667_670543.3333333333334829.0DPF motifs-containing proteins
TgeneSGIP1chr1:65886423chr1:67184976ENST000003710371725813_818543.3333333333334829.0DPF motifs-containing proteins
TgeneSGIP1chr1:65886423chr1:67184976ENST000003710391422667_670346.3333333333333632.0DPF motifs-containing proteins
TgeneSGIP1chr1:65886423chr1:67184976ENST000003710391422813_818346.3333333333333632.0DPF motifs-containing proteins
TgeneSGIP1chr1:65886423chr1:67184977ENST000002372471927667_670574.3333333333334860.0DPF motifs-containing proteins
TgeneSGIP1chr1:65886423chr1:67184977ENST000002372471927813_818574.3333333333334860.0DPF motifs-containing proteins
TgeneSGIP1chr1:65886423chr1:67184977ENST000003710371725667_670543.3333333333334829.0DPF motifs-containing proteins
TgeneSGIP1chr1:65886423chr1:67184977ENST000003710371725813_818543.3333333333334829.0DPF motifs-containing proteins
TgeneSGIP1chr1:65886423chr1:67184977ENST000003710391422667_670346.3333333333333632.0DPF motifs-containing proteins
TgeneSGIP1chr1:65886423chr1:67184977ENST000003710391422813_818346.3333333333333632.0DPF motifs-containing proteins
TgeneSGIP1chr1:65886423chr1:67184976ENST000002372471927593_595574.3333333333334860.0DPF motifs-containing proteins
TgeneSGIP1chr1:65886423chr1:67184976ENST000003710371725561_567543.3333333333334829.0DPF motifs-containing proteins
TgeneSGIP1chr1:65886423chr1:67184976ENST000003710371725593_595543.3333333333334829.0DPF motifs-containing proteins
TgeneSGIP1chr1:65886423chr1:67184976ENST000003710391422561_567346.3333333333333632.0DPF motifs-containing proteins
TgeneSGIP1chr1:65886423chr1:67184976ENST000003710391422593_595346.3333333333333632.0DPF motifs-containing proteins
TgeneSGIP1chr1:65886423chr1:67184977ENST000002372471927593_595574.3333333333334860.0DPF motifs-containing proteins
TgeneSGIP1chr1:65886423chr1:67184977ENST000003710371725561_567543.3333333333334829.0DPF motifs-containing proteins
TgeneSGIP1chr1:65886423chr1:67184977ENST000003710371725593_595543.3333333333334829.0DPF motifs-containing proteins
TgeneSGIP1chr1:65886423chr1:67184977ENST000003710391422561_567346.3333333333333632.0DPF motifs-containing proteins
TgeneSGIP1chr1:65886423chr1:67184977ENST000003710391422593_595346.3333333333333632.0DPF motifs-containing proteins


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneSGIP1chr1:65886423chr1:67184976ENST000002372471927561_567574.3333333333334860.0DPF motifs-containing proteins
TgeneSGIP1chr1:65886423chr1:67184977ENST000002372471927561_567574.3333333333334860.0DPF motifs-containing proteins


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for LEPROT-SGIP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for LEPROT-SGIP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource