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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:LETM2-ERCC2 (FusionGDB2 ID:44492)

Fusion Gene Summary for LETM2-ERCC2

check button Fusion gene summary
Fusion gene informationFusion gene name: LETM2-ERCC2
Fusion gene ID: 44492
HgeneTgene
Gene symbol

LETM2

ERCC2

Gene ID

137994

2068

Gene nameleucine zipper and EF-hand containing transmembrane protein 2ERCC excision repair 2, TFIIH core complex helicase subunit
SynonymsSLC55A2COFS2|EM9|TFIIH|TTD|TTD1|XPD
Cytomap

8p11.23

19q13.32

Type of geneprotein-codingprotein-coding
DescriptionLETM1 domain-containing protein LETM2, mitochondrialLETM1 and EF-hand domain-containing protein 2leucine zipper-EF-hand containing transmembrane protein 1-like proteinleucine zipper-EF-hand containing transmembrane protein 2general transcription and DNA repair factor IIH helicase subunit XPDBTF2 p80CXPDDNA excision repair protein ERCC-2DNA repair protein complementing XP-D cellsTFIIH 80 kDa subunitTFIIH basal transcription factor complex 80 kDa subunitTFIIH basal tran
Modification date2020031320200315
UniProtAcc.

P18074

Ensembl transtripts involved in fusion geneENST00000528827, ENST00000297720, 
ENST00000379957, ENST00000523983, 
ENST00000524874, ENST00000527710, 
ENST00000519476, 		ENST00000221481, 
ENST00000391940, ENST00000391944, 
ENST00000391945, ENST00000485403, 
Fusion gene scores* DoF score1 X 1 X 1=13 X 4 X 3=36
# samples 13
** MAII scorelog2(1/1*10)=3.32192809488736log2(3/36*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: LETM2 [Title/Abstract] AND ERCC2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointLETM2(38262024)-ERCC2(45872405), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneERCC2

GO:0006283

transcription-coupled nucleotide-excision repair

8663148

TgeneERCC2

GO:0006366

transcription by RNA polymerase II

9852112

TgeneERCC2

GO:0045893

positive regulation of transcription, DNA-templated

8692842

TgeneERCC2

GO:0045944

positive regulation of transcription by RNA polymerase II

8692841


check buttonFusion gene breakpoints across LETM2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ERCC2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-85-A53L-01ALETM2chr8

38262024

-ERCC2chr19

45872405

-
ChimerDB4LUSCTCGA-85-A53L-01ALETM2chr8

38262024

+ERCC2chr19

45872405

-


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Fusion Gene ORF analysis for LETM2-ERCC2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000528827ENST00000221481LETM2chr8

38262024

+ERCC2chr19

45872405

-
3UTR-3CDSENST00000528827ENST00000391940LETM2chr8

38262024

+ERCC2chr19

45872405

-
3UTR-3CDSENST00000528827ENST00000391944LETM2chr8

38262024

+ERCC2chr19

45872405

-
3UTR-3CDSENST00000528827ENST00000391945LETM2chr8

38262024

+ERCC2chr19

45872405

-
3UTR-3CDSENST00000528827ENST00000485403LETM2chr8

38262024

+ERCC2chr19

45872405

-
In-frameENST00000297720ENST00000221481LETM2chr8

38262024

+ERCC2chr19

45872405

-
In-frameENST00000297720ENST00000391940LETM2chr8

38262024

+ERCC2chr19

45872405

-
In-frameENST00000297720ENST00000391944LETM2chr8

38262024

+ERCC2chr19

45872405

-
In-frameENST00000297720ENST00000391945LETM2chr8

38262024

+ERCC2chr19

45872405

-
In-frameENST00000297720ENST00000485403LETM2chr8

38262024

+ERCC2chr19

45872405

-
In-frameENST00000379957ENST00000221481LETM2chr8

38262024

+ERCC2chr19

45872405

-
In-frameENST00000379957ENST00000391940LETM2chr8

38262024

+ERCC2chr19

45872405

-
In-frameENST00000379957ENST00000391944LETM2chr8

38262024

+ERCC2chr19

45872405

-
In-frameENST00000379957ENST00000391945LETM2chr8

38262024

+ERCC2chr19

45872405

-
In-frameENST00000379957ENST00000485403LETM2chr8

38262024

+ERCC2chr19

45872405

-
In-frameENST00000523983ENST00000221481LETM2chr8

38262024

+ERCC2chr19

45872405

-
In-frameENST00000523983ENST00000391940LETM2chr8

38262024

+ERCC2chr19

45872405

-
In-frameENST00000523983ENST00000391944LETM2chr8

38262024

+ERCC2chr19

45872405

-
In-frameENST00000523983ENST00000391945LETM2chr8

38262024

+ERCC2chr19

45872405

-
In-frameENST00000523983ENST00000485403LETM2chr8

38262024

+ERCC2chr19

45872405

-
In-frameENST00000524874ENST00000221481LETM2chr8

38262024

+ERCC2chr19

45872405

-
In-frameENST00000524874ENST00000391940LETM2chr8

38262024

+ERCC2chr19

45872405

-
In-frameENST00000524874ENST00000391944LETM2chr8

38262024

+ERCC2chr19

45872405

-
In-frameENST00000524874ENST00000391945LETM2chr8

38262024

+ERCC2chr19

45872405

-
In-frameENST00000524874ENST00000485403LETM2chr8

38262024

+ERCC2chr19

45872405

-
In-frameENST00000527710ENST00000221481LETM2chr8

38262024

+ERCC2chr19

45872405

-
In-frameENST00000527710ENST00000391940LETM2chr8

38262024

+ERCC2chr19

45872405

-
In-frameENST00000527710ENST00000391944LETM2chr8

38262024

+ERCC2chr19

45872405

-
In-frameENST00000527710ENST00000391945LETM2chr8

38262024

+ERCC2chr19

45872405

-
In-frameENST00000527710ENST00000485403LETM2chr8

38262024

+ERCC2chr19

45872405

-
intron-3CDSENST00000519476ENST00000221481LETM2chr8

38262024

+ERCC2chr19

45872405

-
intron-3CDSENST00000519476ENST00000391940LETM2chr8

38262024

+ERCC2chr19

45872405

-
intron-3CDSENST00000519476ENST00000391944LETM2chr8

38262024

+ERCC2chr19

45872405

-
intron-3CDSENST00000519476ENST00000391945LETM2chr8

38262024

+ERCC2chr19

45872405

-
intron-3CDSENST00000519476ENST00000485403LETM2chr8

38262024

+ERCC2chr19

45872405

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000297720LETM2chr838262024+ENST00000391945ERCC2chr1945872405-5135116519633421048
ENST00000297720LETM2chr838262024+ENST00000391944ERCC2chr1945872405-313511651963108970
ENST00000297720LETM2chr838262024+ENST00000485403ERCC2chr1945872405-245111651962349717
ENST00000297720LETM2chr838262024+ENST00000391940ERCC2chr1945872405-235011651962349718
ENST00000297720LETM2chr838262024+ENST00000221481ERCC2chr1945872405-178811651961443415
ENST00000524874LETM2chr838262024+ENST00000391945ERCC2chr1945872405-5171120112733781083
ENST00000524874LETM2chr838262024+ENST00000391944ERCC2chr1945872405-3171120112731441005
ENST00000524874LETM2chr838262024+ENST00000485403ERCC2chr1945872405-248712011272385752
ENST00000524874LETM2chr838262024+ENST00000391940ERCC2chr1945872405-238612011272385753
ENST00000524874LETM2chr838262024+ENST00000221481ERCC2chr1945872405-182412011271479450
ENST00000379957LETM2chr838262024+ENST00000391945ERCC2chr1945872405-5315134512735221131
ENST00000379957LETM2chr838262024+ENST00000391944ERCC2chr1945872405-3315134512732881053
ENST00000379957LETM2chr838262024+ENST00000485403ERCC2chr1945872405-263113451272529800
ENST00000379957LETM2chr838262024+ENST00000391940ERCC2chr1945872405-253013451272529801
ENST00000379957LETM2chr838262024+ENST00000221481ERCC2chr1945872405-196813451271623498
ENST00000523983LETM2chr838262024+ENST00000391945ERCC2chr1945872405-5219124913634261096
ENST00000523983LETM2chr838262024+ENST00000391944ERCC2chr1945872405-3219124913631921018
ENST00000523983LETM2chr838262024+ENST00000485403ERCC2chr1945872405-253512491362433765
ENST00000523983LETM2chr838262024+ENST00000391940ERCC2chr1945872405-243412491362433766
ENST00000523983LETM2chr838262024+ENST00000221481ERCC2chr1945872405-187212491361527463
ENST00000527710LETM2chr838262024+ENST00000391945ERCC2chr1945872405-47037331572910917
ENST00000527710LETM2chr838262024+ENST00000391944ERCC2chr1945872405-27037331572676839
ENST00000527710LETM2chr838262024+ENST00000485403ERCC2chr1945872405-20197331571917586
ENST00000527710LETM2chr838262024+ENST00000391940ERCC2chr1945872405-19187331571917587
ENST00000527710LETM2chr838262024+ENST00000221481ERCC2chr1945872405-13567331571011284

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000297720ENST00000391945LETM2chr838262024+ERCC2chr1945872405-0.0025119130.997488
ENST00000297720ENST00000391944LETM2chr838262024+ERCC2chr1945872405-0.0051057230.99489427
ENST00000297720ENST00000485403LETM2chr838262024+ERCC2chr1945872405-0.0137276380.98627234
ENST00000297720ENST00000391940LETM2chr838262024+ERCC2chr1945872405-0.0147546960.9852453
ENST00000297720ENST00000221481LETM2chr838262024+ERCC2chr1945872405-0.0071438340.99285614
ENST00000524874ENST00000391945LETM2chr838262024+ERCC2chr1945872405-0.0022299770.9977701
ENST00000524874ENST00000391944LETM2chr838262024+ERCC2chr1945872405-0.0043748530.9956252
ENST00000524874ENST00000485403LETM2chr838262024+ERCC2chr1945872405-0.016646280.98335373
ENST00000524874ENST00000391940LETM2chr838262024+ERCC2chr1945872405-0.0175173260.9824827
ENST00000524874ENST00000221481LETM2chr838262024+ERCC2chr1945872405-0.0167010630.98329896
ENST00000379957ENST00000391945LETM2chr838262024+ERCC2chr1945872405-0.0023999930.9976
ENST00000379957ENST00000391944LETM2chr838262024+ERCC2chr1945872405-0.0041258020.9958742
ENST00000379957ENST00000485403LETM2chr838262024+ERCC2chr1945872405-0.0120496180.98795044
ENST00000379957ENST00000391940LETM2chr838262024+ERCC2chr1945872405-0.0129832430.98701674
ENST00000379957ENST00000221481LETM2chr838262024+ERCC2chr1945872405-0.0150649130.98493505
ENST00000523983ENST00000391945LETM2chr838262024+ERCC2chr1945872405-0.0025638310.9974362
ENST00000523983ENST00000391944LETM2chr838262024+ERCC2chr1945872405-0.0045738810.9954261
ENST00000523983ENST00000485403LETM2chr838262024+ERCC2chr1945872405-0.0120653910.9879346
ENST00000523983ENST00000391940LETM2chr838262024+ERCC2chr1945872405-0.0135049510.986495
ENST00000523983ENST00000221481LETM2chr838262024+ERCC2chr1945872405-0.0089796310.9910204
ENST00000527710ENST00000391945LETM2chr838262024+ERCC2chr1945872405-0.0026170210.99738294
ENST00000527710ENST00000391944LETM2chr838262024+ERCC2chr1945872405-0.0106554470.98934454
ENST00000527710ENST00000485403LETM2chr838262024+ERCC2chr1945872405-0.0135248310.98647517
ENST00000527710ENST00000391940LETM2chr838262024+ERCC2chr1945872405-0.0147649720.985235
ENST00000527710ENST00000221481LETM2chr838262024+ERCC2chr1945872405-0.0065480310.99345195

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Fusion Genomic Features for LETM2-ERCC2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for LETM2-ERCC2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:38262024/chr19:45872405)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.ERCC2

P18074

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: ATP-dependent 5'-3' DNA helicase, component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. The ATP-dependent helicase activity of XPD/ERCC2 is required for DNA opening. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription. XPD/ERCC2 acts by forming a bridge between CAK and the core-TFIIH complex. Involved in the regulation of vitamin-D receptor activity. As part of the mitotic spindle-associated MMXD complex it plays a role in chromosome segregation. Might have a role in aging process and could play a causative role in the generation of skin cancers. {ECO:0000269|PubMed:10024882, ECO:0000269|PubMed:15494306, ECO:0000269|PubMed:20797633, ECO:0000269|PubMed:8413672}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLETM2chr8:38262024chr19:45872405ENST00000297720+710208_235311397.0Coiled coilOntology_term=ECO:0000255
HgeneLETM2chr8:38262024chr19:45872405ENST00000379957+811208_235406492.0Coiled coilOntology_term=ECO:0000255
HgeneLETM2chr8:38262024chr19:45872405ENST00000523983+811208_235359445.0Coiled coilOntology_term=ECO:0000255
HgeneLETM2chr8:38262024chr19:45872405ENST00000379957+811382_385406492.0Compositional biasNote=Poly-Leu
HgeneLETM2chr8:38262024chr19:45872405ENST00000297720+71026_177311397.0Topological domainMitochondrial intermembrane
HgeneLETM2chr8:38262024chr19:45872405ENST00000379957+81126_177406492.0Topological domainMitochondrial intermembrane
HgeneLETM2chr8:38262024chr19:45872405ENST00000523983+81126_177359445.0Topological domainMitochondrial intermembrane
HgeneLETM2chr8:38262024chr19:45872405ENST00000527710+5826_177192278.0Topological domainMitochondrial intermembrane
HgeneLETM2chr8:38262024chr19:45872405ENST00000297720+710178_198311397.0TransmembraneHelical
HgeneLETM2chr8:38262024chr19:45872405ENST00000379957+811178_198406492.0TransmembraneHelical
HgeneLETM2chr8:38262024chr19:45872405ENST00000523983+811178_198359445.0TransmembraneHelical
TgeneERCC2chr8:38262024chr19:45872405ENST00000391940113234_23711406.0MotifNote=DEAH box
TgeneERCC2chr8:38262024chr19:45872405ENST00000391940113682_69511406.0MotifNuclear localization signal
TgeneERCC2chr8:38262024chr19:45872405ENST00000391945123234_23735761.0MotifNote=DEAH box
TgeneERCC2chr8:38262024chr19:45872405ENST00000391945123682_69535761.0MotifNuclear localization signal
TgeneERCC2chr8:38262024chr19:45872405ENST00000485403012234_23711406.0MotifNote=DEAH box
TgeneERCC2chr8:38262024chr19:45872405ENST00000485403012682_69511406.0MotifNuclear localization signal
TgeneERCC2chr8:38262024chr19:45872405ENST0000039194011342_4911406.0Nucleotide bindingATP
TgeneERCC2chr8:38262024chr19:45872405ENST0000039194512342_4935761.0Nucleotide bindingATP
TgeneERCC2chr8:38262024chr19:45872405ENST0000048540301242_4911406.0Nucleotide bindingATP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLETM2chr8:38262024chr19:45872405ENST00000527710+58208_235192278.0Coiled coilOntology_term=ECO:0000255
HgeneLETM2chr8:38262024chr19:45872405ENST00000297720+710382_385311397.0Compositional biasNote=Poly-Leu
HgeneLETM2chr8:38262024chr19:45872405ENST00000523983+811382_385359445.0Compositional biasNote=Poly-Leu
HgeneLETM2chr8:38262024chr19:45872405ENST00000527710+58382_385192278.0Compositional biasNote=Poly-Leu
HgeneLETM2chr8:38262024chr19:45872405ENST00000297720+710221_438311397.0DomainLetm1 RBD
HgeneLETM2chr8:38262024chr19:45872405ENST00000379957+811221_438406492.0DomainLetm1 RBD
HgeneLETM2chr8:38262024chr19:45872405ENST00000523983+811221_438359445.0DomainLetm1 RBD
HgeneLETM2chr8:38262024chr19:45872405ENST00000527710+58221_438192278.0DomainLetm1 RBD
HgeneLETM2chr8:38262024chr19:45872405ENST00000297720+710199_491311397.0Topological domainMitochondrial matrix
HgeneLETM2chr8:38262024chr19:45872405ENST00000379957+811199_491406492.0Topological domainMitochondrial matrix
HgeneLETM2chr8:38262024chr19:45872405ENST00000523983+811199_491359445.0Topological domainMitochondrial matrix
HgeneLETM2chr8:38262024chr19:45872405ENST00000527710+58199_491192278.0Topological domainMitochondrial matrix
HgeneLETM2chr8:38262024chr19:45872405ENST00000527710+58178_198192278.0TransmembraneHelical
TgeneERCC2chr8:38262024chr19:45872405ENST000003919401137_28311406.0DomainHelicase ATP-binding
TgeneERCC2chr8:38262024chr19:45872405ENST000003919451237_28335761.0DomainHelicase ATP-binding
TgeneERCC2chr8:38262024chr19:45872405ENST000004854030127_28311406.0DomainHelicase ATP-binding


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Fusion Gene Sequence for LETM2-ERCC2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>44492_44492_1_LETM2-ERCC2_LETM2_chr8_38262024_ENST00000297720_ERCC2_chr19_45872405_ENST00000221481_length(transcript)=1788nt_BP=1165nt
AGAGTGACGTCAGGGGCGAGGAAAGAGGCGGAACCGTAGAGACTTGGCTTCGGGCCCTTCTAGCTTGGGGGTCCCGGGAAGGAGCTGGGA
GGACCTAGGCGGCCGTTCCGCGGAGCCCGGCCGAGGAGGTCCCTATGTTAACTACTTGAGACAAAAATAAATATGGCCTTCTACAGTTAT
AATTCAGTTCTGGCTATTGCTCGAACAAGATTCCCATTTAAATAAGACATGTATGAAGAACTATGAGAGCAAGAAGTACTCGGATCCTAG
TCAGCCAGGCAATACAGTACTTCACCCAGGAACTAGACTAATACAAAAGCTACACACATCCACTTGCTGGCTGCAAGAAGTTCCTGGCAA
ACCTCAGCTGGAGCAAGCCACAAAACATCCACAGGTGACAAGCCCTCAGGCCACAAAAGAAACTGGCATGGAGATTAAAGAAGGCAAACA
ATCTTATAGACAAAAAATCATGGATGAACTAAAATATTATTACAATGGATTCTACTTACTTTGGATTGACGCCAAAGTTGCTGCCAGAAT
GGTTTGGAGGCTGTTGCATGGACAGGTCCTGACCAGACGAGAGAGACGAAGGGAAGAAAAACAGAAAAAGAAAATGGCTGTAAAGTTGGA
ACTAGCAAAATTTCTTCAAGAAACCATGACAGAAATGGCAAGGAGGAACAGAGCCAAGATGGGCGATGCCTCTACACAGCTCTCATCCTA
CGTGAAGCAGGTCCAGACAGGCCACAAGCCCAGCACAAAGGAGATAGTTCGCTTCTCCAAACTATTTGAGGACCAGCTGGCCCTGGAACA
CTTAGATCGCCCTCAGCTGGTTGCCCTTTGCAAACTGCTGGAATTGCAGACATTTGGAACCAACAACCTGCTCCGCTTTCAGCTCCTGAT
GAAACTGAAGTCTATAAAAGCAGATGATGAAATAATTGCCAAGGAAGGGGTGACAGCATTGAGTGTATCAGAACTACAGGCTGCCTGTAG
GGCCCGAGGGATGAGATCACTGGGTCTCACGGAGGAACAACTGCGACAACAGCTCACGGAGTGGCAGGACCTCCACCTGAAGGAGAACGT
CCCTCCTTCCCTTTTGCTCCTGTCCCGCACCTTCTACCTGATAGATGTGAAGCCCAAGCCGATTGAGATACCACTCAGTGGGGAGGGTCA
TGGAGTCCTGGAGATGCCCTCAGGCACCGGGAAGACAGTATCCCTGTTGGCCCTGATCATGGCATACCAGAGAGCATATCCGCTGGAGGT
GACCAAACTCATCTACTGCTCAAGAACTGTGCCAGAGATTGAGAAGGTGATTGAAGAGCTTCGAAAGTTGCTCAACTTCTATGAGAAGCA
GGAGGGCGAGAAGCTGCCGTTTCTGGGACTGGCTCTGAGCTCCCGCAAAAACTTGTGTATTCACCCTGAGACAACGTCTGCATCGACTCC
ATGAGCGTCAACCTCACCCGCCGGACCCTTGACCGGTGCCAGGGCAACCTGGAGACCCTGCAGAAGACGGTGCTCAGGATCAAAGAGACA
GACGAGCAGCGCCTGCGGGACGAGTACCGGCGTCTGGTGGAGGGGCTGCGGGAGGCCAGCGCCGCCCGGGAGACGGACGCCCACCTGGCC
AACCCCGTGCTGCCCGACGAAGTGCTGCAGGAGGCAGTGCCTGGCTCCATCCGCACGGCCGAGCATTTCCTGGGCTTCCTGAGGCGGCTG

>44492_44492_1_LETM2-ERCC2_LETM2_chr8_38262024_ENST00000297720_ERCC2_chr19_45872405_ENST00000221481_length(amino acids)=415AA_BP=323
MLEQDSHLNKTCMKNYESKKYSDPSQPGNTVLHPGTRLIQKLHTSTCWLQEVPGKPQLEQATKHPQVTSPQATKETGMEIKEGKQSYRQK
IMDELKYYYNGFYLLWIDAKVAARMVWRLLHGQVLTRRERRREEKQKKKMAVKLELAKFLQETMTEMARRNRAKMGDASTQLSSYVKQVQ
TGHKPSTKEIVRFSKLFEDQLALEHLDRPQLVALCKLLELQTFGTNNLLRFQLLMKLKSIKADDEIIAKEGVTALSVSELQAACRARGMR
SLGLTEEQLRQQLTEWQDLHLKENVPPSLLLLSRTFYLIDVKPKPIEIPLSGEGHGVLEMPSGTGKTVSLLALIMAYQRAYPLEVTKLIY

--------------------------------------------------------------
>44492_44492_2_LETM2-ERCC2_LETM2_chr8_38262024_ENST00000297720_ERCC2_chr19_45872405_ENST00000391940_length(transcript)=2350nt_BP=1165nt
AGAGTGACGTCAGGGGCGAGGAAAGAGGCGGAACCGTAGAGACTTGGCTTCGGGCCCTTCTAGCTTGGGGGTCCCGGGAAGGAGCTGGGA
GGACCTAGGCGGCCGTTCCGCGGAGCCCGGCCGAGGAGGTCCCTATGTTAACTACTTGAGACAAAAATAAATATGGCCTTCTACAGTTAT
AATTCAGTTCTGGCTATTGCTCGAACAAGATTCCCATTTAAATAAGACATGTATGAAGAACTATGAGAGCAAGAAGTACTCGGATCCTAG
TCAGCCAGGCAATACAGTACTTCACCCAGGAACTAGACTAATACAAAAGCTACACACATCCACTTGCTGGCTGCAAGAAGTTCCTGGCAA
ACCTCAGCTGGAGCAAGCCACAAAACATCCACAGGTGACAAGCCCTCAGGCCACAAAAGAAACTGGCATGGAGATTAAAGAAGGCAAACA
ATCTTATAGACAAAAAATCATGGATGAACTAAAATATTATTACAATGGATTCTACTTACTTTGGATTGACGCCAAAGTTGCTGCCAGAAT
GGTTTGGAGGCTGTTGCATGGACAGGTCCTGACCAGACGAGAGAGACGAAGGGAAGAAAAACAGAAAAAGAAAATGGCTGTAAAGTTGGA
ACTAGCAAAATTTCTTCAAGAAACCATGACAGAAATGGCAAGGAGGAACAGAGCCAAGATGGGCGATGCCTCTACACAGCTCTCATCCTA
CGTGAAGCAGGTCCAGACAGGCCACAAGCCCAGCACAAAGGAGATAGTTCGCTTCTCCAAACTATTTGAGGACCAGCTGGCCCTGGAACA
CTTAGATCGCCCTCAGCTGGTTGCCCTTTGCAAACTGCTGGAATTGCAGACATTTGGAACCAACAACCTGCTCCGCTTTCAGCTCCTGAT
GAAACTGAAGTCTATAAAAGCAGATGATGAAATAATTGCCAAGGAAGGGGTGACAGCATTGAGTGTATCAGAACTACAGGCTGCCTGTAG
GGCCCGAGGGATGAGATCACTGGGTCTCACGGAGGAACAACTGCGACAACAGCTCACGGAGTGGCAGGACCTCCACCTGAAGGAGAACGT
CCCTCCTTCCCTTTTGCTCCTGTCCCGCACCTTCTACCTGATAGATGTGAAGCCCAAGCCGATTGAGATACCACTCAGTGGGGAGGGTCA
TGGAGTCCTGGAGATGCCCTCAGGCACCGGGAAGACAGTATCCCTGTTGGCCCTGATCATGGCATACCAGAGAGCATATCCGCTGGAGGT
GACCAAACTCATCTACTGCTCAAGAACTGTGCCAGAGATTGAGAAGGTGATTGAAGAGCTTCGAAAGTTGCTCAACTTCTATGAGAAGCA
GGAGGGCGAGAAGCTGCCGTTTCTGGGACTGGCTCTGAGCTCCCGCAAAAACTTGTGTATTCACCCTGAGGTGACACCCCTGCGCTTTGG
GAAGGACGTCGATGGGAAATGCCACAGCCTCACAGCCTCCTATGTGCGGGCGCAGTACCAGCATGACACCAGCCTGCCCCACTGCCGATT
CTATGAGGAATTTGATGCCCATGGGCGTGAGGTGCCCCTCCCCGCTGGCATCTACAACCTGGATGACCTGAAGGCCCTGGGGCGGCGCCA
GGGCTGGTGCCCATACTTCCTTGCTCGATACTCAATCCTGCATGCCAATGTGGTGGTTTATAGCTACCACTACCTCCTGGACCCCAAGAT
TGCAGACCTGGTGTCCAAGGAACTGGCCCGCAAGGCCGTCGTGGTCTTCGACGAGGCCCACAACATTGACAACGTCTGCATCGACTCCAT
GAGCGTCAACCTCACCCGCCGGACCCTTGACCGGTGCCAGGGCAACCTGGAGACCCTGCAGAAGACGGTGCTCAGGATCAAAGAGACAGA
CGAGCAGCGCCTGCGGGACGAGTACCGGCGTCTGGTGGAGGGGCTGCGGGAGGCCAGCGCCGCCCGGGAGACGGACGCCCACCTGGCCAA
CCCCGTGCTGCCCGACGAAGTGCTGCAGGAGGCAGTGCCTGGCTCCATCCGCACGGCCGAGCATTTCCTGGGCTTCCTGAGGCGGCTGCT
GGAGTACGTGAAGTGGCGGCTGCGTGTGCAGCATGTGGTGCAGGAGAGCCCGCCCGCCTTCCTGAGCGGCCTGGCCCAGCGCGTGTGCAT
CCAGCGCAAGCCCCTCAGATTCTGTGCTGAACGCCTCCGGTCCCTGCTGCATACTCTGGAGATCACCGACCTTGCTGACTTCTCCCCGCT
CACCCTCCTTGCTAACTTTGCCACCCTTGTCAGCACCTACGCCAAAGGCCAGGCTCAGCACTGTGGAAGCAGCAGGAACCAAAAAAGATC

>44492_44492_2_LETM2-ERCC2_LETM2_chr8_38262024_ENST00000297720_ERCC2_chr19_45872405_ENST00000391940_length(amino acids)=718AA_BP=323
MLEQDSHLNKTCMKNYESKKYSDPSQPGNTVLHPGTRLIQKLHTSTCWLQEVPGKPQLEQATKHPQVTSPQATKETGMEIKEGKQSYRQK
IMDELKYYYNGFYLLWIDAKVAARMVWRLLHGQVLTRRERRREEKQKKKMAVKLELAKFLQETMTEMARRNRAKMGDASTQLSSYVKQVQ
TGHKPSTKEIVRFSKLFEDQLALEHLDRPQLVALCKLLELQTFGTNNLLRFQLLMKLKSIKADDEIIAKEGVTALSVSELQAACRARGMR
SLGLTEEQLRQQLTEWQDLHLKENVPPSLLLLSRTFYLIDVKPKPIEIPLSGEGHGVLEMPSGTGKTVSLLALIMAYQRAYPLEVTKLIY
CSRTVPEIEKVIEELRKLLNFYEKQEGEKLPFLGLALSSRKNLCIHPEVTPLRFGKDVDGKCHSLTASYVRAQYQHDTSLPHCRFYEEFD
AHGREVPLPAGIYNLDDLKALGRRQGWCPYFLARYSILHANVVVYSYHYLLDPKIADLVSKELARKAVVVFDEAHNIDNVCIDSMSVNLT
RRTLDRCQGNLETLQKTVLRIKETDEQRLRDEYRRLVEGLREASAARETDAHLANPVLPDEVLQEAVPGSIRTAEHFLGFLRRLLEYVKW

--------------------------------------------------------------
>44492_44492_3_LETM2-ERCC2_LETM2_chr8_38262024_ENST00000297720_ERCC2_chr19_45872405_ENST00000391944_length(transcript)=3135nt_BP=1165nt
AGAGTGACGTCAGGGGCGAGGAAAGAGGCGGAACCGTAGAGACTTGGCTTCGGGCCCTTCTAGCTTGGGGGTCCCGGGAAGGAGCTGGGA
GGACCTAGGCGGCCGTTCCGCGGAGCCCGGCCGAGGAGGTCCCTATGTTAACTACTTGAGACAAAAATAAATATGGCCTTCTACAGTTAT
AATTCAGTTCTGGCTATTGCTCGAACAAGATTCCCATTTAAATAAGACATGTATGAAGAACTATGAGAGCAAGAAGTACTCGGATCCTAG
TCAGCCAGGCAATACAGTACTTCACCCAGGAACTAGACTAATACAAAAGCTACACACATCCACTTGCTGGCTGCAAGAAGTTCCTGGCAA
ACCTCAGCTGGAGCAAGCCACAAAACATCCACAGGTGACAAGCCCTCAGGCCACAAAAGAAACTGGCATGGAGATTAAAGAAGGCAAACA
ATCTTATAGACAAAAAATCATGGATGAACTAAAATATTATTACAATGGATTCTACTTACTTTGGATTGACGCCAAAGTTGCTGCCAGAAT
GGTTTGGAGGCTGTTGCATGGACAGGTCCTGACCAGACGAGAGAGACGAAGGGAAGAAAAACAGAAAAAGAAAATGGCTGTAAAGTTGGA
ACTAGCAAAATTTCTTCAAGAAACCATGACAGAAATGGCAAGGAGGAACAGAGCCAAGATGGGCGATGCCTCTACACAGCTCTCATCCTA
CGTGAAGCAGGTCCAGACAGGCCACAAGCCCAGCACAAAGGAGATAGTTCGCTTCTCCAAACTATTTGAGGACCAGCTGGCCCTGGAACA
CTTAGATCGCCCTCAGCTGGTTGCCCTTTGCAAACTGCTGGAATTGCAGACATTTGGAACCAACAACCTGCTCCGCTTTCAGCTCCTGAT
GAAACTGAAGTCTATAAAAGCAGATGATGAAATAATTGCCAAGGAAGGGGTGACAGCATTGAGTGTATCAGAACTACAGGCTGCCTGTAG
GGCCCGAGGGATGAGATCACTGGGTCTCACGGAGGAACAACTGCGACAACAGCTCACGGAGTGGCAGGACCTCCACCTGAAGGAGAACGT
CCCTCCTTCCCTTTTGCTCCTGTCCCGCACCTTCTACCTGATAGATGTGAAGCCCAAGCCGATTGAGATACCACTCAGTGGGGAGGGTCA
TGGAGTCCTGGAGATGCCCTCAGGCACCGGGAAGACAGTATCCCTGTTGGCCCTGATCATGGCATACCAGAGAGCATATCCGCTGGAGGT
GACCAAACTCATCTACTGCTCAAGAACTGTGCCAGAGATTGAGAAGGTGATTGAAGAGCTTCGAAAGTTGCTCAACTTCTATGAGAAGCA
GGAGGGCGAGAAGCTGCCGTTTCTGGGACTGGCTCTGAGCTCCCGCAAAAACTTGTGTATTCACCCTGAGATCCTGCATGCCAATGTGGT
GGTTTATAGCTACCACTACCTCCTGGACCCCAAGATTGCAGACCTGGTGTCCAAGGAACTGGCCCGCAAGGCCGTCGTGGTCTTCGACGA
GGCCCACAACATTGACAACGTCTGCATCGACTCCATGAGCGTCAACCTCACCCGCCGGACCCTTGACCGGTGCCAGGGCAACCTGGAGAC
CCTGCAGAAGACGGTGCTCAGGATCAAAGAGACAGACGAGCAGCGCCTGCGGGACGAGTACCGGCGTCTGGTGGAGGGGCTGCGGGAGGC
CAGCGCCGCCCGGGAGACGGACGCCCACCTGGCCAACCCCGTGCTGCCCGACGAAGTGCTGCAGGAGGCAGTGCCTGGCTCCATCCGCAC
GGCCGAGCATTTCCTGGGCTTCCTGAGGCGGCTGCTGGAGTACGTGAAGTGGCGGCTGCGTGTGCAGCATGTGGTGCAGGAGAGCCCGCC
CGCCTTCCTGAGCGGCCTGGCCCAGCGCGTGTGCATCCAGCGCAAGCCCCTCAGATTCTGTGCTGAACGCCTCCGGTCCCTGCTGCATAC
TCTGGAGATCACCGACCTTGCTGACTTCTCCCCGCTCACCCTCCTTGCTAACTTTGCCACCCTTGTCAGCACCTACGCCAAAGGCTTCAC
CATCATCATCGAGCCCTTTGACGACAGAACCCCGACCATTGCCAACCCCATCCTGCACTTCAGCTGCATGGACGCCTCGCTGGCCATCAA
ACCCGTATTTGAGCGTTTCCAGTCTGTCATCATCACATCTGGGACACTGTCCCCGCTGGACATCTACCCCAAGATCCTGGACTTCCACCC
CGTCACCATGGCAACCTTCACCATGACGCTGGCACGGGTCTGCCTCTGCCCTATGATCATCGGCCGTGGCAATGACCAGGTGGCCATCAG
CTCCAAATTTGAGACCCGGGAGGATATTGCTGTGATCCGGAACTATGGGAACCTCCTGCTGGAGATGTCCGCTGTGGTCCCTGATGGCAT
CGTGGCCTTCTTCACCAGCTACCAGTACATGGAGAGCACCGTGGCCTCCTGGTATGAGCAGGGGATCCTTGAGAACATCCAGAGGAACAA
GCTGCTCTTTATTGAGACCCAGGATGGTGCCGAAACCAGTGTCGCCCTGGAGAAGTACCAGGAGGCCTGCGAGAATGGCCGCGGGGCCAT
CCTGCTGTCAGTGGCCCGGGGCAAAGTGTCCGAGGGAATCGACTTTGTGCACCACTACGGGCGGGCCGTCATCATGTTTGGCGTCCCCTA
CGTCTACACACAGAGCCGCATTCTCAAGGCGCGGCTGGAATACCTGCGGGACCAGTTCCAGATTCGTGAGAATGACTTTCTTACCTTCGA
TGCCATGCGCCACGCGGCCCAGTGTGTGGGTCGGGCCATCAGGGGCAAGACGGACTACGGCCTCATGGTCTTTGCCGACAAGCGGTTTGC
CCGTGGGGACAAGCGGGGGAAGCTGCCCCGCTGGATCCAGGAGCACCTCACAGATGCCAACCTCAACCTGACCGTGGACGAGGGTGTCCA
GGTGGCCAAGTACTTCCTGCGGCAGATGGCACAGCCCTTCCACCGGGAGGATCAGCTGGGCCTGTCCCTGCTCAGCCTGGAGCAGCTAGA

>44492_44492_3_LETM2-ERCC2_LETM2_chr8_38262024_ENST00000297720_ERCC2_chr19_45872405_ENST00000391944_length(amino acids)=970AA_BP=323
MLEQDSHLNKTCMKNYESKKYSDPSQPGNTVLHPGTRLIQKLHTSTCWLQEVPGKPQLEQATKHPQVTSPQATKETGMEIKEGKQSYRQK
IMDELKYYYNGFYLLWIDAKVAARMVWRLLHGQVLTRRERRREEKQKKKMAVKLELAKFLQETMTEMARRNRAKMGDASTQLSSYVKQVQ
TGHKPSTKEIVRFSKLFEDQLALEHLDRPQLVALCKLLELQTFGTNNLLRFQLLMKLKSIKADDEIIAKEGVTALSVSELQAACRARGMR
SLGLTEEQLRQQLTEWQDLHLKENVPPSLLLLSRTFYLIDVKPKPIEIPLSGEGHGVLEMPSGTGKTVSLLALIMAYQRAYPLEVTKLIY
CSRTVPEIEKVIEELRKLLNFYEKQEGEKLPFLGLALSSRKNLCIHPEILHANVVVYSYHYLLDPKIADLVSKELARKAVVVFDEAHNID
NVCIDSMSVNLTRRTLDRCQGNLETLQKTVLRIKETDEQRLRDEYRRLVEGLREASAARETDAHLANPVLPDEVLQEAVPGSIRTAEHFL
GFLRRLLEYVKWRLRVQHVVQESPPAFLSGLAQRVCIQRKPLRFCAERLRSLLHTLEITDLADFSPLTLLANFATLVSTYAKGFTIIIEP
FDDRTPTIANPILHFSCMDASLAIKPVFERFQSVIITSGTLSPLDIYPKILDFHPVTMATFTMTLARVCLCPMIIGRGNDQVAISSKFET
REDIAVIRNYGNLLLEMSAVVPDGIVAFFTSYQYMESTVASWYEQGILENIQRNKLLFIETQDGAETSVALEKYQEACENGRGAILLSVA
RGKVSEGIDFVHHYGRAVIMFGVPYVYTQSRILKARLEYLRDQFQIRENDFLTFDAMRHAAQCVGRAIRGKTDYGLMVFADKRFARGDKR

--------------------------------------------------------------
>44492_44492_4_LETM2-ERCC2_LETM2_chr8_38262024_ENST00000297720_ERCC2_chr19_45872405_ENST00000391945_length(transcript)=5135nt_BP=1165nt
AGAGTGACGTCAGGGGCGAGGAAAGAGGCGGAACCGTAGAGACTTGGCTTCGGGCCCTTCTAGCTTGGGGGTCCCGGGAAGGAGCTGGGA
GGACCTAGGCGGCCGTTCCGCGGAGCCCGGCCGAGGAGGTCCCTATGTTAACTACTTGAGACAAAAATAAATATGGCCTTCTACAGTTAT
AATTCAGTTCTGGCTATTGCTCGAACAAGATTCCCATTTAAATAAGACATGTATGAAGAACTATGAGAGCAAGAAGTACTCGGATCCTAG
TCAGCCAGGCAATACAGTACTTCACCCAGGAACTAGACTAATACAAAAGCTACACACATCCACTTGCTGGCTGCAAGAAGTTCCTGGCAA
ACCTCAGCTGGAGCAAGCCACAAAACATCCACAGGTGACAAGCCCTCAGGCCACAAAAGAAACTGGCATGGAGATTAAAGAAGGCAAACA
ATCTTATAGACAAAAAATCATGGATGAACTAAAATATTATTACAATGGATTCTACTTACTTTGGATTGACGCCAAAGTTGCTGCCAGAAT
GGTTTGGAGGCTGTTGCATGGACAGGTCCTGACCAGACGAGAGAGACGAAGGGAAGAAAAACAGAAAAAGAAAATGGCTGTAAAGTTGGA
ACTAGCAAAATTTCTTCAAGAAACCATGACAGAAATGGCAAGGAGGAACAGAGCCAAGATGGGCGATGCCTCTACACAGCTCTCATCCTA
CGTGAAGCAGGTCCAGACAGGCCACAAGCCCAGCACAAAGGAGATAGTTCGCTTCTCCAAACTATTTGAGGACCAGCTGGCCCTGGAACA
CTTAGATCGCCCTCAGCTGGTTGCCCTTTGCAAACTGCTGGAATTGCAGACATTTGGAACCAACAACCTGCTCCGCTTTCAGCTCCTGAT
GAAACTGAAGTCTATAAAAGCAGATGATGAAATAATTGCCAAGGAAGGGGTGACAGCATTGAGTGTATCAGAACTACAGGCTGCCTGTAG
GGCCCGAGGGATGAGATCACTGGGTCTCACGGAGGAACAACTGCGACAACAGCTCACGGAGTGGCAGGACCTCCACCTGAAGGAGAACGT
CCCTCCTTCCCTTTTGCTCCTGTCCCGCACCTTCTACCTGATAGATGTGAAGCCCAAGCCGATTGAGATACCACTCAGTGGGGAGGGTCA
TGGAGTCCTGGAGATGCCCTCAGGCACCGGGAAGACAGTATCCCTGTTGGCCCTGATCATGGCATACCAGAGAGCATATCCGCTGGAGGT
GACCAAACTCATCTACTGCTCAAGAACTGTGCCAGAGATTGAGAAGGTGATTGAAGAGCTTCGAAAGTTGCTCAACTTCTATGAGAAGCA
GGAGGGCGAGAAGCTGCCGTTTCTGGGACTGGCTCTGAGCTCCCGCAAAAACTTGTGTATTCACCCTGAGGTGACACCCCTGCGCTTTGG
GAAGGACGTCGATGGGAAATGCCACAGCCTCACAGCCTCCTATGTGCGGGCGCAGTACCAGCATGACACCAGCCTGCCCCACTGCCGATT
CTATGAGGAATTTGATGCCCATGGGCGTGAGGTGCCCCTCCCCGCTGGCATCTACAACCTGGATGACCTGAAGGCCCTGGGGCGGCGCCA
GGGCTGGTGCCCATACTTCCTTGCTCGATACTCAATCCTGCATGCCAATGTGGTGGTTTATAGCTACCACTACCTCCTGGACCCCAAGAT
TGCAGACCTGGTGTCCAAGGAACTGGCCCGCAAGGCCGTCGTGGTCTTCGACGAGGCCCACAACATTGACAACGTCTGCATCGACTCCAT
GAGCGTCAACCTCACCCGCCGGACCCTTGACCGGTGCCAGGGCAACCTGGAGACCCTGCAGAAGACGGTGCTCAGGATCAAAGAGACAGA
CGAGCAGCGCCTGCGGGACGAGTACCGGCGTCTGGTGGAGGGGCTGCGGGAGGCCAGCGCCGCCCGGGAGACGGACGCCCACCTGGCCAA
CCCCGTGCTGCCCGACGAAGTGCTGCAGGAGGCAGTGCCTGGCTCCATCCGCACGGCCGAGCATTTCCTGGGCTTCCTGAGGCGGCTGCT
GGAGTACGTGAAGTGGCGGCTGCGTGTGCAGCATGTGGTGCAGGAGAGCCCGCCCGCCTTCCTGAGCGGCCTGGCCCAGCGCGTGTGCAT
CCAGCGCAAGCCCCTCAGATTCTGTGCTGAACGCCTCCGGTCCCTGCTGCATACTCTGGAGATCACCGACCTTGCTGACTTCTCCCCGCT
CACCCTCCTTGCTAACTTTGCCACCCTTGTCAGCACCTACGCCAAAGGCTTCACCATCATCATCGAGCCCTTTGACGACAGAACCCCGAC
CATTGCCAACCCCATCCTGCACTTCAGCTGCATGGACGCCTCGCTGGCCATCAAACCCGTATTTGAGCGTTTCCAGTCTGTCATCATCAC
ATCTGGGACACTGTCCCCGCTGGACATCTACCCCAAGATCCTGGACTTCCACCCCGTCACCATGGCAACCTTCACCATGACGCTGGCACG
GGTCTGCCTCTGCCCTATGATCATCGGCCGTGGCAATGACCAGGTGGCCATCAGCTCCAAATTTGAGACCCGGGAGGATATTGCTGTGAT
CCGGAACTATGGGAACCTCCTGCTGGAGATGTCCGCTGTGGTCCCTGATGGCATCGTGGCCTTCTTCACCAGCTACCAGTACATGGAGAG
CACCGTGGCCTCCTGGTATGAGCAGGGGATCCTTGAGAACATCCAGAGGAACAAGCTGCTCTTTATTGAGACCCAGGATGGTGCCGAAAC
CAGTGTCGCCCTGGAGAAGTACCAGGAGGCCTGCGAGAATGGCCGCGGGGCCATCCTGCTGTCAGTGGCCCGGGGCAAAGTGTCCGAGGG
AATCGACTTTGTGCACCACTACGGGCGGGCCGTCATCATGTTTGGCGTCCCCTACGTCTACACACAGAGCCGCATTCTCAAGGCGCGGCT
GGAATACCTGCGGGACCAGTTCCAGATTCGTGAGAATGACTTTCTTACCTTCGATGCCATGCGCCACGCGGCCCAGTGTGTGGGTCGGGC
CATCAGGGGCAAGACGGACTACGGCCTCATGGTCTTTGCCGACAAGCGGTTTGCCCGTGGGGACAAGCGGGGGAAGCTGCCCCGCTGGAT
CCAGGAGCACCTCACAGATGCCAACCTCAACCTGACCGTGGACGAGGGTGTCCAGGTGGCCAAGTACTTCCTGCGGCAGATGGCACAGCC
CTTCCACCGGGAGGATCAGCTGGGCCTGTCCCTGCTCAGCCTGGAGCAGCTAGAATCAGAGGAGACGCTGAAGAGGATAGAGCAGATTGC
TCAGCAGCTCTGAGTGGGGCGGGTGGGGCCATAAACGGTTCCTGGTGACTCCTGAGTCTTGCCTGGCCCTGGTTCCCAGCGGCGGTGGTG
CTAGAAGGTCTTATGAAGTCAGGTGACATTTCTCACTGTCACGTCCACAGCCTTTAATCGCAGGAGAAGGCAGCTATCCACCAGGTACCC
AGAGGCAAGGGGGGGCCAGGAGATGATAGACCCCCTCTCACCCCACCAGCCCATCCCTCCTGCACTGTTCCCAAGAAGCTGCGGCCAGCG
CAGTTCACTGGACGTTAGTGGGGGCTCAGGTCCTGGGTGCTGGCGCTGAGGGTCCGAGGGGCCTTGTCCAGGTGCCAGCTGGGAAACTGG
AGACAGGCACAGGGGATGGTTGGAGGGGAGGTGAGGGGCAAGTGTTACATCCACCCTCCAGCTCCAGGTCCAGCCTGGCAGCCAACTATC
CAACCCCCTCGCCTCTACCCCAAGTAAAACCCATCTTTGCTCCTGTCCTGGGTCTCTTCTGACACCAACCCACCACCTGCTGACTCCACC
ACTGGCCCGACCGCCCTGCCTTTGCCTCATCTCTGCACCTACCCACATGGCCTCCTCTATTTTTGACCCAGATGTCCCCCTCACCTGAGT
CCCAGGAGCCCTTGGAGCATCCACGTTCAGTGTGTTGAGTGACATGGCTCTCTTCATTCTGCAAAGAGGGCAGCAGGGAGGAAATGAGTG
AATCCAGGAGTGGCCCCCCTCCACGAGGGACCTTTCCAGCACAGGGTTTGATCTGTGTGTATCACAGGGGAGATGGGAGCCATGGAAGGT
TCTTGAGCAAGATGGGGGTGGGGGTGGGGTGGGCTGTGGATTCTGCTGATGTCAGGGCTCTTTGCCGACCTGATCAACACTCACCCGGCT
GCTCCTGCCGCCGCCTCGCCTCGGAGCCGGGAGACCAGCTTCTCACTTCCTCGCCTGATAGACTCACGGATCTTGGAGAGTGAGCTGCTG
CGGCGAAGGGCCTGGGGAGGGGCCGGGGATGCTGCTCAGTCCCCCAGGCCCATGCAGTCCCCACGCCCACCCCAGGAGCCGAAGCACAGC
CCATCCTCACCTGTTCTGCGTCACCAGCTGTGCCTGTGTTGGGGGCACCTAGGGGGAAAGATGGGGGACACTGAGATGGGGACATAGAGA
AGCCACCAGGAGGGAAGACAGACAGGGGCTAGGGGCTCACCGAGAGGGGCGGGTAGGTCCTCCTTGTGGAGGATTTCTTTGTACAGCTCT
TCCGCTTGTTGATACTTGTTCTGTTTCAGGTAGGCTGAGGCCTGCGGAGAAGGGAGTGTCTGGGAACTTTTCGGACCCCAGTTCCCAACA
CTGCATCCAGTCCCGCCTTTTTTTTTTTTTTTGTAGAGACAGGGGTCTTGGTATGTTGCCCAGGCTGGTCTTGAACTCCTAGCCTCAAGT
GATCCTCCTGCCTTGGCCTCCCAAAGTGTTGGGGTTACAAGCGTGAACCACCACGTCTGGCCCCACTTTCTAATGTGCTGACCTGGCCGT
ATCCTTCCCCTGCCTAAAGCCTTGCCCTGGGGCAGAGTGGGTTTGGAGCTCGGCCTTACTTCCTGCCCTGGGGATGGAGGACAGGCAGCC
TCCTGTTTCTGAGCCTGTCTGCTGTACTTTGGGCTGGTGGCATGGCCTCGGTGCCTCAGTCTTCCCACACGCAAAGTGGAGCGACAGCTC
CCACCTCATAGGGACGCTATAAGAACTAGCGATGTGGGGACCGGGCTAAGAGGGGAGCCGGCCACAGTGAGCTCAATAAATGTCTGCTGC

>44492_44492_4_LETM2-ERCC2_LETM2_chr8_38262024_ENST00000297720_ERCC2_chr19_45872405_ENST00000391945_length(amino acids)=1048AA_BP=323
MLEQDSHLNKTCMKNYESKKYSDPSQPGNTVLHPGTRLIQKLHTSTCWLQEVPGKPQLEQATKHPQVTSPQATKETGMEIKEGKQSYRQK
IMDELKYYYNGFYLLWIDAKVAARMVWRLLHGQVLTRRERRREEKQKKKMAVKLELAKFLQETMTEMARRNRAKMGDASTQLSSYVKQVQ
TGHKPSTKEIVRFSKLFEDQLALEHLDRPQLVALCKLLELQTFGTNNLLRFQLLMKLKSIKADDEIIAKEGVTALSVSELQAACRARGMR
SLGLTEEQLRQQLTEWQDLHLKENVPPSLLLLSRTFYLIDVKPKPIEIPLSGEGHGVLEMPSGTGKTVSLLALIMAYQRAYPLEVTKLIY
CSRTVPEIEKVIEELRKLLNFYEKQEGEKLPFLGLALSSRKNLCIHPEVTPLRFGKDVDGKCHSLTASYVRAQYQHDTSLPHCRFYEEFD
AHGREVPLPAGIYNLDDLKALGRRQGWCPYFLARYSILHANVVVYSYHYLLDPKIADLVSKELARKAVVVFDEAHNIDNVCIDSMSVNLT
RRTLDRCQGNLETLQKTVLRIKETDEQRLRDEYRRLVEGLREASAARETDAHLANPVLPDEVLQEAVPGSIRTAEHFLGFLRRLLEYVKW
RLRVQHVVQESPPAFLSGLAQRVCIQRKPLRFCAERLRSLLHTLEITDLADFSPLTLLANFATLVSTYAKGFTIIIEPFDDRTPTIANPI
LHFSCMDASLAIKPVFERFQSVIITSGTLSPLDIYPKILDFHPVTMATFTMTLARVCLCPMIIGRGNDQVAISSKFETREDIAVIRNYGN
LLLEMSAVVPDGIVAFFTSYQYMESTVASWYEQGILENIQRNKLLFIETQDGAETSVALEKYQEACENGRGAILLSVARGKVSEGIDFVH
HYGRAVIMFGVPYVYTQSRILKARLEYLRDQFQIRENDFLTFDAMRHAAQCVGRAIRGKTDYGLMVFADKRFARGDKRGKLPRWIQEHLT

--------------------------------------------------------------
>44492_44492_5_LETM2-ERCC2_LETM2_chr8_38262024_ENST00000297720_ERCC2_chr19_45872405_ENST00000485403_length(transcript)=2451nt_BP=1165nt
AGAGTGACGTCAGGGGCGAGGAAAGAGGCGGAACCGTAGAGACTTGGCTTCGGGCCCTTCTAGCTTGGGGGTCCCGGGAAGGAGCTGGGA
GGACCTAGGCGGCCGTTCCGCGGAGCCCGGCCGAGGAGGTCCCTATGTTAACTACTTGAGACAAAAATAAATATGGCCTTCTACAGTTAT
AATTCAGTTCTGGCTATTGCTCGAACAAGATTCCCATTTAAATAAGACATGTATGAAGAACTATGAGAGCAAGAAGTACTCGGATCCTAG
TCAGCCAGGCAATACAGTACTTCACCCAGGAACTAGACTAATACAAAAGCTACACACATCCACTTGCTGGCTGCAAGAAGTTCCTGGCAA
ACCTCAGCTGGAGCAAGCCACAAAACATCCACAGGTGACAAGCCCTCAGGCCACAAAAGAAACTGGCATGGAGATTAAAGAAGGCAAACA
ATCTTATAGACAAAAAATCATGGATGAACTAAAATATTATTACAATGGATTCTACTTACTTTGGATTGACGCCAAAGTTGCTGCCAGAAT
GGTTTGGAGGCTGTTGCATGGACAGGTCCTGACCAGACGAGAGAGACGAAGGGAAGAAAAACAGAAAAAGAAAATGGCTGTAAAGTTGGA
ACTAGCAAAATTTCTTCAAGAAACCATGACAGAAATGGCAAGGAGGAACAGAGCCAAGATGGGCGATGCCTCTACACAGCTCTCATCCTA
CGTGAAGCAGGTCCAGACAGGCCACAAGCCCAGCACAAAGGAGATAGTTCGCTTCTCCAAACTATTTGAGGACCAGCTGGCCCTGGAACA
CTTAGATCGCCCTCAGCTGGTTGCCCTTTGCAAACTGCTGGAATTGCAGACATTTGGAACCAACAACCTGCTCCGCTTTCAGCTCCTGAT
GAAACTGAAGTCTATAAAAGCAGATGATGAAATAATTGCCAAGGAAGGGGTGACAGCATTGAGTGTATCAGAACTACAGGCTGCCTGTAG
GGCCCGAGGGATGAGATCACTGGGTCTCACGGAGGAACAACTGCGACAACAGCTCACGGAGTGGCAGGACCTCCACCTGAAGGAGAACGT
CCCTCCTTCCCTTTTGCTCCTGTCCCGCACCTTCTACCTGATAGATGTGAAGCCCAAGCCGATTGAGATACCACTCAGTGGGGAGGGTCA
TGGAGTCCTGGAGATGCCCTCAGGCACCGGGAAGACAGTATCCCTGTTGGCCCTGATCATGGCATACCAGAGAGCATATCCGCTGGAGGT
GACCAAACTCATCTACTGCTCAAGAACTGTGCCAGAGATTGAGAAGGTGATTGAAGAGCTTCGAAAGTTGCTCAACTTCTATGAGAAGCA
GGAGGGCGAGAAGCTGCCGTTTCTGGGACTGGCTCTGAGCTCCCGCAAAAACTTGTGTATTCACCCTGAGGTGACACCCCTGCGCTTTGG
GAAGGACGTCGATGGGAAATGCCACAGCCTCACAGCCTCCTATGTGCGGGCGCAGTACCAGCATGACACCAGCCTGCCCCACTGCCGATT
CTATGAGGAATTTGATGCCCATGGGCGTGAGGTGCCCCTCCCCGCTGGCATCTACAACCTGGATGACCTGAAGGCCCTGGGGCGGCGCCA
GGGCTGGTGCCCATACTTCCTTGCTCGATACTCAATCCTGCATGCCAATGTGGTGGTTTATAGCTACCACTACCTCCTGGACCCCAAGAT
TGCAGACCTGGTGTCCAAGGAACTGGCCCGCAAGGCCGTCGTGGTCTTCGACGAGGCCCACAACATTGACAACGTCTGCATCGACTCCAT
GAGCGTCAACCTCACCCGCCGGACCCTTGACCGGTGCCAGGGCAACCTGGAGACCCTGCAGAAGACGGTGCTCAGGATCAAAGAGACAGA
CGAGCAGCGCCTGCGGGACGAGTACCGGCGTCTGGTGGAGGGGCTGCGGGAGGCCAGCGCCGCCCGGGAGACGGACGCCCACCTGGCCAA
CCCCGTGCTGCCCGACGAAGTGCTGCAGGAGGCAGTGCCTGGCTCCATCCGCACGGCCGAGCATTTCCTGGGCTTCCTGAGGCGGCTGCT
GGAGTACGTGAAGTGGCGGCTGCGTGTGCAGCATGTGGTGCAGGAGAGCCCGCCCGCCTTCCTGAGCGGCCTGGCCCAGCGCGTGTGCAT
CCAGCGCAAGCCCCTCAGATTCTGTGCTGAACGCCTCCGGTCCCTGCTGCATACTCTGGAGATCACCGACCTTGCTGACTTCTCCCCGCT
CACCCTCCTTGCTAACTTTGCCACCCTTGTCAGCACCTACGCCAAAGGCCAGGCTCAGCACTGTGGAAGCAGCAGGAACCAAAAAAGATC
TCATCCCTAACCCCCCAGAACTTATATTCCAGATGGGAAAACCAGTAGCAAAGATGCAGCCAAATAAACAAGGAAATAATTCCAGAAAGT

>44492_44492_5_LETM2-ERCC2_LETM2_chr8_38262024_ENST00000297720_ERCC2_chr19_45872405_ENST00000485403_length(amino acids)=717AA_BP=323
MLEQDSHLNKTCMKNYESKKYSDPSQPGNTVLHPGTRLIQKLHTSTCWLQEVPGKPQLEQATKHPQVTSPQATKETGMEIKEGKQSYRQK
IMDELKYYYNGFYLLWIDAKVAARMVWRLLHGQVLTRRERRREEKQKKKMAVKLELAKFLQETMTEMARRNRAKMGDASTQLSSYVKQVQ
TGHKPSTKEIVRFSKLFEDQLALEHLDRPQLVALCKLLELQTFGTNNLLRFQLLMKLKSIKADDEIIAKEGVTALSVSELQAACRARGMR
SLGLTEEQLRQQLTEWQDLHLKENVPPSLLLLSRTFYLIDVKPKPIEIPLSGEGHGVLEMPSGTGKTVSLLALIMAYQRAYPLEVTKLIY
CSRTVPEIEKVIEELRKLLNFYEKQEGEKLPFLGLALSSRKNLCIHPEVTPLRFGKDVDGKCHSLTASYVRAQYQHDTSLPHCRFYEEFD
AHGREVPLPAGIYNLDDLKALGRRQGWCPYFLARYSILHANVVVYSYHYLLDPKIADLVSKELARKAVVVFDEAHNIDNVCIDSMSVNLT
RRTLDRCQGNLETLQKTVLRIKETDEQRLRDEYRRLVEGLREASAARETDAHLANPVLPDEVLQEAVPGSIRTAEHFLGFLRRLLEYVKW

--------------------------------------------------------------
>44492_44492_6_LETM2-ERCC2_LETM2_chr8_38262024_ENST00000379957_ERCC2_chr19_45872405_ENST00000221481_length(transcript)=1968nt_BP=1345nt
GTAGAGACTTGGCTTCGGGCCCTTCTAGCTTGGGGGTCCCGGGAAGGAGCTGGGAGGACCTAGGCGGCCGTTCCGCGGAGCCCGGCCGAG
GAGGTCCCTATGTTAACTACTTGAGACAAAAATAAATATGGCCTTCTACAGTTATAATTCAGTTCTGGCTATTGCTCGAACAAGATTCCC
TAGCCATTTTGTCCATCCTACCTGCTCTTCTTATTCCCCATCATGTGCATTTCTTCACTTGCCAGATTCCCATTTAAATAAGACATGTAT
GAAGAACTATGAGAGCAAGAAGTACTCGGATCCTAGTCAGCCAGGCAATACAGTACTTCACCCAGGAACTAGACTAATACAAAAGCTACA
CACATCCACTTGCTGGCTGCAAGAAGTTCCTGGCAAACCTCAGCTGGAGCAAGCCACAAAACATCCACAGGTGACAAGCCCTCAGGCCAC
AAAAGAAACTGGCATGGAGATTAAAGAAGGCAAACAATCTTATAGACAAAAAATCATGGATGAACTAAAATATTATTACAATGGATTCTA
CTTACTTTGGATTGACGCCAAAGTTGCTGCCAGAATGGTTTGGAGGCTGTTGCATGGACAGGTCCTGACCAGACGAGAGAGACGAAGGCT
GTTGAGAACTTGTGTTGATTTCTTCCGCCTGGTTCCATTTATGGTGTTCTTAATTGTACCCTTCATGGAATTCTTATTACCAGTGTTTCT
GAAACTCTTCCCAGAGATGTTGCCATCAACTTTTGAAAGTGAATCCAAAAAGGAAGAAAAACAGAAAAAGAAAATGGCTGTAAAGTTGGA
ACTAGCAAAATTTCTTCAAGAAACCATGACAGAAATGGCAAGGAGGAACAGAGCCAAGATGGGCGATGCCTCTACACAGCTCTCATCCTA
CGTGAAGCAGGTCCAGACAGGCCACAAGCCCAGCACAAAGGAGATAGTTCGCTTCTCCAAACTATTTGAGGACCAGCTGGCCCTGGAACA
CTTAGATCGCCCTCAGCTGGTTGCCCTTTGCAAACTGCTGGAATTGCAGACATTTGGAACCAACAACCTGCTCCGCTTTCAGCTCCTGAT
GAAACTGAAGTCTATAAAAGCAGATGATGAAATAATTGCCAAGGAAGGGGTGACAGCATTGAGTGTATCAGAACTACAGGCTGCCTGTAG
GGCCCGAGGGATGAGATCACTGGGTCTCACGGAGGAACAACTGCGACAACAGCTCACGGAGTGGCAGGACCTCCACCTGAAGGAGAACGT
CCCTCCTTCCCTTTTGCTCCTGTCCCGCACCTTCTACCTGATAGATGTGAAGCCCAAGCCGATTGAGATACCACTCAGTGGGGAGGGTCA
TGGAGTCCTGGAGATGCCCTCAGGCACCGGGAAGACAGTATCCCTGTTGGCCCTGATCATGGCATACCAGAGAGCATATCCGCTGGAGGT
GACCAAACTCATCTACTGCTCAAGAACTGTGCCAGAGATTGAGAAGGTGATTGAAGAGCTTCGAAAGTTGCTCAACTTCTATGAGAAGCA
GGAGGGCGAGAAGCTGCCGTTTCTGGGACTGGCTCTGAGCTCCCGCAAAAACTTGTGTATTCACCCTGAGACAACGTCTGCATCGACTCC
ATGAGCGTCAACCTCACCCGCCGGACCCTTGACCGGTGCCAGGGCAACCTGGAGACCCTGCAGAAGACGGTGCTCAGGATCAAAGAGACA
GACGAGCAGCGCCTGCGGGACGAGTACCGGCGTCTGGTGGAGGGGCTGCGGGAGGCCAGCGCCGCCCGGGAGACGGACGCCCACCTGGCC
AACCCCGTGCTGCCCGACGAAGTGCTGCAGGAGGCAGTGCCTGGCTCCATCCGCACGGCCGAGCATTTCCTGGGCTTCCTGAGGCGGCTG

>44492_44492_6_LETM2-ERCC2_LETM2_chr8_38262024_ENST00000379957_ERCC2_chr19_45872405_ENST00000221481_length(amino acids)=498AA_BP=406
MAFYSYNSVLAIARTRFPSHFVHPTCSSYSPSCAFLHLPDSHLNKTCMKNYESKKYSDPSQPGNTVLHPGTRLIQKLHTSTCWLQEVPGK
PQLEQATKHPQVTSPQATKETGMEIKEGKQSYRQKIMDELKYYYNGFYLLWIDAKVAARMVWRLLHGQVLTRRERRRLLRTCVDFFRLVP
FMVFLIVPFMEFLLPVFLKLFPEMLPSTFESESKKEEKQKKKMAVKLELAKFLQETMTEMARRNRAKMGDASTQLSSYVKQVQTGHKPST
KEIVRFSKLFEDQLALEHLDRPQLVALCKLLELQTFGTNNLLRFQLLMKLKSIKADDEIIAKEGVTALSVSELQAACRARGMRSLGLTEE
QLRQQLTEWQDLHLKENVPPSLLLLSRTFYLIDVKPKPIEIPLSGEGHGVLEMPSGTGKTVSLLALIMAYQRAYPLEVTKLIYCSRTVPE

--------------------------------------------------------------
>44492_44492_7_LETM2-ERCC2_LETM2_chr8_38262024_ENST00000379957_ERCC2_chr19_45872405_ENST00000391940_length(transcript)=2530nt_BP=1345nt
GTAGAGACTTGGCTTCGGGCCCTTCTAGCTTGGGGGTCCCGGGAAGGAGCTGGGAGGACCTAGGCGGCCGTTCCGCGGAGCCCGGCCGAG
GAGGTCCCTATGTTAACTACTTGAGACAAAAATAAATATGGCCTTCTACAGTTATAATTCAGTTCTGGCTATTGCTCGAACAAGATTCCC
TAGCCATTTTGTCCATCCTACCTGCTCTTCTTATTCCCCATCATGTGCATTTCTTCACTTGCCAGATTCCCATTTAAATAAGACATGTAT
GAAGAACTATGAGAGCAAGAAGTACTCGGATCCTAGTCAGCCAGGCAATACAGTACTTCACCCAGGAACTAGACTAATACAAAAGCTACA
CACATCCACTTGCTGGCTGCAAGAAGTTCCTGGCAAACCTCAGCTGGAGCAAGCCACAAAACATCCACAGGTGACAAGCCCTCAGGCCAC
AAAAGAAACTGGCATGGAGATTAAAGAAGGCAAACAATCTTATAGACAAAAAATCATGGATGAACTAAAATATTATTACAATGGATTCTA
CTTACTTTGGATTGACGCCAAAGTTGCTGCCAGAATGGTTTGGAGGCTGTTGCATGGACAGGTCCTGACCAGACGAGAGAGACGAAGGCT
GTTGAGAACTTGTGTTGATTTCTTCCGCCTGGTTCCATTTATGGTGTTCTTAATTGTACCCTTCATGGAATTCTTATTACCAGTGTTTCT
GAAACTCTTCCCAGAGATGTTGCCATCAACTTTTGAAAGTGAATCCAAAAAGGAAGAAAAACAGAAAAAGAAAATGGCTGTAAAGTTGGA
ACTAGCAAAATTTCTTCAAGAAACCATGACAGAAATGGCAAGGAGGAACAGAGCCAAGATGGGCGATGCCTCTACACAGCTCTCATCCTA
CGTGAAGCAGGTCCAGACAGGCCACAAGCCCAGCACAAAGGAGATAGTTCGCTTCTCCAAACTATTTGAGGACCAGCTGGCCCTGGAACA
CTTAGATCGCCCTCAGCTGGTTGCCCTTTGCAAACTGCTGGAATTGCAGACATTTGGAACCAACAACCTGCTCCGCTTTCAGCTCCTGAT
GAAACTGAAGTCTATAAAAGCAGATGATGAAATAATTGCCAAGGAAGGGGTGACAGCATTGAGTGTATCAGAACTACAGGCTGCCTGTAG
GGCCCGAGGGATGAGATCACTGGGTCTCACGGAGGAACAACTGCGACAACAGCTCACGGAGTGGCAGGACCTCCACCTGAAGGAGAACGT
CCCTCCTTCCCTTTTGCTCCTGTCCCGCACCTTCTACCTGATAGATGTGAAGCCCAAGCCGATTGAGATACCACTCAGTGGGGAGGGTCA
TGGAGTCCTGGAGATGCCCTCAGGCACCGGGAAGACAGTATCCCTGTTGGCCCTGATCATGGCATACCAGAGAGCATATCCGCTGGAGGT
GACCAAACTCATCTACTGCTCAAGAACTGTGCCAGAGATTGAGAAGGTGATTGAAGAGCTTCGAAAGTTGCTCAACTTCTATGAGAAGCA
GGAGGGCGAGAAGCTGCCGTTTCTGGGACTGGCTCTGAGCTCCCGCAAAAACTTGTGTATTCACCCTGAGGTGACACCCCTGCGCTTTGG
GAAGGACGTCGATGGGAAATGCCACAGCCTCACAGCCTCCTATGTGCGGGCGCAGTACCAGCATGACACCAGCCTGCCCCACTGCCGATT
CTATGAGGAATTTGATGCCCATGGGCGTGAGGTGCCCCTCCCCGCTGGCATCTACAACCTGGATGACCTGAAGGCCCTGGGGCGGCGCCA
GGGCTGGTGCCCATACTTCCTTGCTCGATACTCAATCCTGCATGCCAATGTGGTGGTTTATAGCTACCACTACCTCCTGGACCCCAAGAT
TGCAGACCTGGTGTCCAAGGAACTGGCCCGCAAGGCCGTCGTGGTCTTCGACGAGGCCCACAACATTGACAACGTCTGCATCGACTCCAT
GAGCGTCAACCTCACCCGCCGGACCCTTGACCGGTGCCAGGGCAACCTGGAGACCCTGCAGAAGACGGTGCTCAGGATCAAAGAGACAGA
CGAGCAGCGCCTGCGGGACGAGTACCGGCGTCTGGTGGAGGGGCTGCGGGAGGCCAGCGCCGCCCGGGAGACGGACGCCCACCTGGCCAA
CCCCGTGCTGCCCGACGAAGTGCTGCAGGAGGCAGTGCCTGGCTCCATCCGCACGGCCGAGCATTTCCTGGGCTTCCTGAGGCGGCTGCT
GGAGTACGTGAAGTGGCGGCTGCGTGTGCAGCATGTGGTGCAGGAGAGCCCGCCCGCCTTCCTGAGCGGCCTGGCCCAGCGCGTGTGCAT
CCAGCGCAAGCCCCTCAGATTCTGTGCTGAACGCCTCCGGTCCCTGCTGCATACTCTGGAGATCACCGACCTTGCTGACTTCTCCCCGCT
CACCCTCCTTGCTAACTTTGCCACCCTTGTCAGCACCTACGCCAAAGGCCAGGCTCAGCACTGTGGAAGCAGCAGGAACCAAAAAAGATC

>44492_44492_7_LETM2-ERCC2_LETM2_chr8_38262024_ENST00000379957_ERCC2_chr19_45872405_ENST00000391940_length(amino acids)=801AA_BP=406
MAFYSYNSVLAIARTRFPSHFVHPTCSSYSPSCAFLHLPDSHLNKTCMKNYESKKYSDPSQPGNTVLHPGTRLIQKLHTSTCWLQEVPGK
PQLEQATKHPQVTSPQATKETGMEIKEGKQSYRQKIMDELKYYYNGFYLLWIDAKVAARMVWRLLHGQVLTRRERRRLLRTCVDFFRLVP
FMVFLIVPFMEFLLPVFLKLFPEMLPSTFESESKKEEKQKKKMAVKLELAKFLQETMTEMARRNRAKMGDASTQLSSYVKQVQTGHKPST
KEIVRFSKLFEDQLALEHLDRPQLVALCKLLELQTFGTNNLLRFQLLMKLKSIKADDEIIAKEGVTALSVSELQAACRARGMRSLGLTEE
QLRQQLTEWQDLHLKENVPPSLLLLSRTFYLIDVKPKPIEIPLSGEGHGVLEMPSGTGKTVSLLALIMAYQRAYPLEVTKLIYCSRTVPE
IEKVIEELRKLLNFYEKQEGEKLPFLGLALSSRKNLCIHPEVTPLRFGKDVDGKCHSLTASYVRAQYQHDTSLPHCRFYEEFDAHGREVP
LPAGIYNLDDLKALGRRQGWCPYFLARYSILHANVVVYSYHYLLDPKIADLVSKELARKAVVVFDEAHNIDNVCIDSMSVNLTRRTLDRC
QGNLETLQKTVLRIKETDEQRLRDEYRRLVEGLREASAARETDAHLANPVLPDEVLQEAVPGSIRTAEHFLGFLRRLLEYVKWRLRVQHV

--------------------------------------------------------------
>44492_44492_8_LETM2-ERCC2_LETM2_chr8_38262024_ENST00000379957_ERCC2_chr19_45872405_ENST00000391944_length(transcript)=3315nt_BP=1345nt
GTAGAGACTTGGCTTCGGGCCCTTCTAGCTTGGGGGTCCCGGGAAGGAGCTGGGAGGACCTAGGCGGCCGTTCCGCGGAGCCCGGCCGAG
GAGGTCCCTATGTTAACTACTTGAGACAAAAATAAATATGGCCTTCTACAGTTATAATTCAGTTCTGGCTATTGCTCGAACAAGATTCCC
TAGCCATTTTGTCCATCCTACCTGCTCTTCTTATTCCCCATCATGTGCATTTCTTCACTTGCCAGATTCCCATTTAAATAAGACATGTAT
GAAGAACTATGAGAGCAAGAAGTACTCGGATCCTAGTCAGCCAGGCAATACAGTACTTCACCCAGGAACTAGACTAATACAAAAGCTACA
CACATCCACTTGCTGGCTGCAAGAAGTTCCTGGCAAACCTCAGCTGGAGCAAGCCACAAAACATCCACAGGTGACAAGCCCTCAGGCCAC
AAAAGAAACTGGCATGGAGATTAAAGAAGGCAAACAATCTTATAGACAAAAAATCATGGATGAACTAAAATATTATTACAATGGATTCTA
CTTACTTTGGATTGACGCCAAAGTTGCTGCCAGAATGGTTTGGAGGCTGTTGCATGGACAGGTCCTGACCAGACGAGAGAGACGAAGGCT
GTTGAGAACTTGTGTTGATTTCTTCCGCCTGGTTCCATTTATGGTGTTCTTAATTGTACCCTTCATGGAATTCTTATTACCAGTGTTTCT
GAAACTCTTCCCAGAGATGTTGCCATCAACTTTTGAAAGTGAATCCAAAAAGGAAGAAAAACAGAAAAAGAAAATGGCTGTAAAGTTGGA
ACTAGCAAAATTTCTTCAAGAAACCATGACAGAAATGGCAAGGAGGAACAGAGCCAAGATGGGCGATGCCTCTACACAGCTCTCATCCTA
CGTGAAGCAGGTCCAGACAGGCCACAAGCCCAGCACAAAGGAGATAGTTCGCTTCTCCAAACTATTTGAGGACCAGCTGGCCCTGGAACA
CTTAGATCGCCCTCAGCTGGTTGCCCTTTGCAAACTGCTGGAATTGCAGACATTTGGAACCAACAACCTGCTCCGCTTTCAGCTCCTGAT
GAAACTGAAGTCTATAAAAGCAGATGATGAAATAATTGCCAAGGAAGGGGTGACAGCATTGAGTGTATCAGAACTACAGGCTGCCTGTAG
GGCCCGAGGGATGAGATCACTGGGTCTCACGGAGGAACAACTGCGACAACAGCTCACGGAGTGGCAGGACCTCCACCTGAAGGAGAACGT
CCCTCCTTCCCTTTTGCTCCTGTCCCGCACCTTCTACCTGATAGATGTGAAGCCCAAGCCGATTGAGATACCACTCAGTGGGGAGGGTCA
TGGAGTCCTGGAGATGCCCTCAGGCACCGGGAAGACAGTATCCCTGTTGGCCCTGATCATGGCATACCAGAGAGCATATCCGCTGGAGGT
GACCAAACTCATCTACTGCTCAAGAACTGTGCCAGAGATTGAGAAGGTGATTGAAGAGCTTCGAAAGTTGCTCAACTTCTATGAGAAGCA
GGAGGGCGAGAAGCTGCCGTTTCTGGGACTGGCTCTGAGCTCCCGCAAAAACTTGTGTATTCACCCTGAGATCCTGCATGCCAATGTGGT
GGTTTATAGCTACCACTACCTCCTGGACCCCAAGATTGCAGACCTGGTGTCCAAGGAACTGGCCCGCAAGGCCGTCGTGGTCTTCGACGA
GGCCCACAACATTGACAACGTCTGCATCGACTCCATGAGCGTCAACCTCACCCGCCGGACCCTTGACCGGTGCCAGGGCAACCTGGAGAC
CCTGCAGAAGACGGTGCTCAGGATCAAAGAGACAGACGAGCAGCGCCTGCGGGACGAGTACCGGCGTCTGGTGGAGGGGCTGCGGGAGGC
CAGCGCCGCCCGGGAGACGGACGCCCACCTGGCCAACCCCGTGCTGCCCGACGAAGTGCTGCAGGAGGCAGTGCCTGGCTCCATCCGCAC
GGCCGAGCATTTCCTGGGCTTCCTGAGGCGGCTGCTGGAGTACGTGAAGTGGCGGCTGCGTGTGCAGCATGTGGTGCAGGAGAGCCCGCC
CGCCTTCCTGAGCGGCCTGGCCCAGCGCGTGTGCATCCAGCGCAAGCCCCTCAGATTCTGTGCTGAACGCCTCCGGTCCCTGCTGCATAC
TCTGGAGATCACCGACCTTGCTGACTTCTCCCCGCTCACCCTCCTTGCTAACTTTGCCACCCTTGTCAGCACCTACGCCAAAGGCTTCAC
CATCATCATCGAGCCCTTTGACGACAGAACCCCGACCATTGCCAACCCCATCCTGCACTTCAGCTGCATGGACGCCTCGCTGGCCATCAA
ACCCGTATTTGAGCGTTTCCAGTCTGTCATCATCACATCTGGGACACTGTCCCCGCTGGACATCTACCCCAAGATCCTGGACTTCCACCC
CGTCACCATGGCAACCTTCACCATGACGCTGGCACGGGTCTGCCTCTGCCCTATGATCATCGGCCGTGGCAATGACCAGGTGGCCATCAG
CTCCAAATTTGAGACCCGGGAGGATATTGCTGTGATCCGGAACTATGGGAACCTCCTGCTGGAGATGTCCGCTGTGGTCCCTGATGGCAT
CGTGGCCTTCTTCACCAGCTACCAGTACATGGAGAGCACCGTGGCCTCCTGGTATGAGCAGGGGATCCTTGAGAACATCCAGAGGAACAA
GCTGCTCTTTATTGAGACCCAGGATGGTGCCGAAACCAGTGTCGCCCTGGAGAAGTACCAGGAGGCCTGCGAGAATGGCCGCGGGGCCAT
CCTGCTGTCAGTGGCCCGGGGCAAAGTGTCCGAGGGAATCGACTTTGTGCACCACTACGGGCGGGCCGTCATCATGTTTGGCGTCCCCTA
CGTCTACACACAGAGCCGCATTCTCAAGGCGCGGCTGGAATACCTGCGGGACCAGTTCCAGATTCGTGAGAATGACTTTCTTACCTTCGA
TGCCATGCGCCACGCGGCCCAGTGTGTGGGTCGGGCCATCAGGGGCAAGACGGACTACGGCCTCATGGTCTTTGCCGACAAGCGGTTTGC
CCGTGGGGACAAGCGGGGGAAGCTGCCCCGCTGGATCCAGGAGCACCTCACAGATGCCAACCTCAACCTGACCGTGGACGAGGGTGTCCA
GGTGGCCAAGTACTTCCTGCGGCAGATGGCACAGCCCTTCCACCGGGAGGATCAGCTGGGCCTGTCCCTGCTCAGCCTGGAGCAGCTAGA

>44492_44492_8_LETM2-ERCC2_LETM2_chr8_38262024_ENST00000379957_ERCC2_chr19_45872405_ENST00000391944_length(amino acids)=1053AA_BP=406
MAFYSYNSVLAIARTRFPSHFVHPTCSSYSPSCAFLHLPDSHLNKTCMKNYESKKYSDPSQPGNTVLHPGTRLIQKLHTSTCWLQEVPGK
PQLEQATKHPQVTSPQATKETGMEIKEGKQSYRQKIMDELKYYYNGFYLLWIDAKVAARMVWRLLHGQVLTRRERRRLLRTCVDFFRLVP
FMVFLIVPFMEFLLPVFLKLFPEMLPSTFESESKKEEKQKKKMAVKLELAKFLQETMTEMARRNRAKMGDASTQLSSYVKQVQTGHKPST
KEIVRFSKLFEDQLALEHLDRPQLVALCKLLELQTFGTNNLLRFQLLMKLKSIKADDEIIAKEGVTALSVSELQAACRARGMRSLGLTEE
QLRQQLTEWQDLHLKENVPPSLLLLSRTFYLIDVKPKPIEIPLSGEGHGVLEMPSGTGKTVSLLALIMAYQRAYPLEVTKLIYCSRTVPE
IEKVIEELRKLLNFYEKQEGEKLPFLGLALSSRKNLCIHPEILHANVVVYSYHYLLDPKIADLVSKELARKAVVVFDEAHNIDNVCIDSM
SVNLTRRTLDRCQGNLETLQKTVLRIKETDEQRLRDEYRRLVEGLREASAARETDAHLANPVLPDEVLQEAVPGSIRTAEHFLGFLRRLL
EYVKWRLRVQHVVQESPPAFLSGLAQRVCIQRKPLRFCAERLRSLLHTLEITDLADFSPLTLLANFATLVSTYAKGFTIIIEPFDDRTPT
IANPILHFSCMDASLAIKPVFERFQSVIITSGTLSPLDIYPKILDFHPVTMATFTMTLARVCLCPMIIGRGNDQVAISSKFETREDIAVI
RNYGNLLLEMSAVVPDGIVAFFTSYQYMESTVASWYEQGILENIQRNKLLFIETQDGAETSVALEKYQEACENGRGAILLSVARGKVSEG
IDFVHHYGRAVIMFGVPYVYTQSRILKARLEYLRDQFQIRENDFLTFDAMRHAAQCVGRAIRGKTDYGLMVFADKRFARGDKRGKLPRWI

--------------------------------------------------------------
>44492_44492_9_LETM2-ERCC2_LETM2_chr8_38262024_ENST00000379957_ERCC2_chr19_45872405_ENST00000391945_length(transcript)=5315nt_BP=1345nt
GTAGAGACTTGGCTTCGGGCCCTTCTAGCTTGGGGGTCCCGGGAAGGAGCTGGGAGGACCTAGGCGGCCGTTCCGCGGAGCCCGGCCGAG
GAGGTCCCTATGTTAACTACTTGAGACAAAAATAAATATGGCCTTCTACAGTTATAATTCAGTTCTGGCTATTGCTCGAACAAGATTCCC
TAGCCATTTTGTCCATCCTACCTGCTCTTCTTATTCCCCATCATGTGCATTTCTTCACTTGCCAGATTCCCATTTAAATAAGACATGTAT
GAAGAACTATGAGAGCAAGAAGTACTCGGATCCTAGTCAGCCAGGCAATACAGTACTTCACCCAGGAACTAGACTAATACAAAAGCTACA
CACATCCACTTGCTGGCTGCAAGAAGTTCCTGGCAAACCTCAGCTGGAGCAAGCCACAAAACATCCACAGGTGACAAGCCCTCAGGCCAC
AAAAGAAACTGGCATGGAGATTAAAGAAGGCAAACAATCTTATAGACAAAAAATCATGGATGAACTAAAATATTATTACAATGGATTCTA
CTTACTTTGGATTGACGCCAAAGTTGCTGCCAGAATGGTTTGGAGGCTGTTGCATGGACAGGTCCTGACCAGACGAGAGAGACGAAGGCT
GTTGAGAACTTGTGTTGATTTCTTCCGCCTGGTTCCATTTATGGTGTTCTTAATTGTACCCTTCATGGAATTCTTATTACCAGTGTTTCT
GAAACTCTTCCCAGAGATGTTGCCATCAACTTTTGAAAGTGAATCCAAAAAGGAAGAAAAACAGAAAAAGAAAATGGCTGTAAAGTTGGA
ACTAGCAAAATTTCTTCAAGAAACCATGACAGAAATGGCAAGGAGGAACAGAGCCAAGATGGGCGATGCCTCTACACAGCTCTCATCCTA
CGTGAAGCAGGTCCAGACAGGCCACAAGCCCAGCACAAAGGAGATAGTTCGCTTCTCCAAACTATTTGAGGACCAGCTGGCCCTGGAACA
CTTAGATCGCCCTCAGCTGGTTGCCCTTTGCAAACTGCTGGAATTGCAGACATTTGGAACCAACAACCTGCTCCGCTTTCAGCTCCTGAT
GAAACTGAAGTCTATAAAAGCAGATGATGAAATAATTGCCAAGGAAGGGGTGACAGCATTGAGTGTATCAGAACTACAGGCTGCCTGTAG
GGCCCGAGGGATGAGATCACTGGGTCTCACGGAGGAACAACTGCGACAACAGCTCACGGAGTGGCAGGACCTCCACCTGAAGGAGAACGT
CCCTCCTTCCCTTTTGCTCCTGTCCCGCACCTTCTACCTGATAGATGTGAAGCCCAAGCCGATTGAGATACCACTCAGTGGGGAGGGTCA
TGGAGTCCTGGAGATGCCCTCAGGCACCGGGAAGACAGTATCCCTGTTGGCCCTGATCATGGCATACCAGAGAGCATATCCGCTGGAGGT
GACCAAACTCATCTACTGCTCAAGAACTGTGCCAGAGATTGAGAAGGTGATTGAAGAGCTTCGAAAGTTGCTCAACTTCTATGAGAAGCA
GGAGGGCGAGAAGCTGCCGTTTCTGGGACTGGCTCTGAGCTCCCGCAAAAACTTGTGTATTCACCCTGAGGTGACACCCCTGCGCTTTGG
GAAGGACGTCGATGGGAAATGCCACAGCCTCACAGCCTCCTATGTGCGGGCGCAGTACCAGCATGACACCAGCCTGCCCCACTGCCGATT
CTATGAGGAATTTGATGCCCATGGGCGTGAGGTGCCCCTCCCCGCTGGCATCTACAACCTGGATGACCTGAAGGCCCTGGGGCGGCGCCA
GGGCTGGTGCCCATACTTCCTTGCTCGATACTCAATCCTGCATGCCAATGTGGTGGTTTATAGCTACCACTACCTCCTGGACCCCAAGAT
TGCAGACCTGGTGTCCAAGGAACTGGCCCGCAAGGCCGTCGTGGTCTTCGACGAGGCCCACAACATTGACAACGTCTGCATCGACTCCAT
GAGCGTCAACCTCACCCGCCGGACCCTTGACCGGTGCCAGGGCAACCTGGAGACCCTGCAGAAGACGGTGCTCAGGATCAAAGAGACAGA
CGAGCAGCGCCTGCGGGACGAGTACCGGCGTCTGGTGGAGGGGCTGCGGGAGGCCAGCGCCGCCCGGGAGACGGACGCCCACCTGGCCAA
CCCCGTGCTGCCCGACGAAGTGCTGCAGGAGGCAGTGCCTGGCTCCATCCGCACGGCCGAGCATTTCCTGGGCTTCCTGAGGCGGCTGCT
GGAGTACGTGAAGTGGCGGCTGCGTGTGCAGCATGTGGTGCAGGAGAGCCCGCCCGCCTTCCTGAGCGGCCTGGCCCAGCGCGTGTGCAT
CCAGCGCAAGCCCCTCAGATTCTGTGCTGAACGCCTCCGGTCCCTGCTGCATACTCTGGAGATCACCGACCTTGCTGACTTCTCCCCGCT
CACCCTCCTTGCTAACTTTGCCACCCTTGTCAGCACCTACGCCAAAGGCTTCACCATCATCATCGAGCCCTTTGACGACAGAACCCCGAC
CATTGCCAACCCCATCCTGCACTTCAGCTGCATGGACGCCTCGCTGGCCATCAAACCCGTATTTGAGCGTTTCCAGTCTGTCATCATCAC
ATCTGGGACACTGTCCCCGCTGGACATCTACCCCAAGATCCTGGACTTCCACCCCGTCACCATGGCAACCTTCACCATGACGCTGGCACG
GGTCTGCCTCTGCCCTATGATCATCGGCCGTGGCAATGACCAGGTGGCCATCAGCTCCAAATTTGAGACCCGGGAGGATATTGCTGTGAT
CCGGAACTATGGGAACCTCCTGCTGGAGATGTCCGCTGTGGTCCCTGATGGCATCGTGGCCTTCTTCACCAGCTACCAGTACATGGAGAG
CACCGTGGCCTCCTGGTATGAGCAGGGGATCCTTGAGAACATCCAGAGGAACAAGCTGCTCTTTATTGAGACCCAGGATGGTGCCGAAAC
CAGTGTCGCCCTGGAGAAGTACCAGGAGGCCTGCGAGAATGGCCGCGGGGCCATCCTGCTGTCAGTGGCCCGGGGCAAAGTGTCCGAGGG
AATCGACTTTGTGCACCACTACGGGCGGGCCGTCATCATGTTTGGCGTCCCCTACGTCTACACACAGAGCCGCATTCTCAAGGCGCGGCT
GGAATACCTGCGGGACCAGTTCCAGATTCGTGAGAATGACTTTCTTACCTTCGATGCCATGCGCCACGCGGCCCAGTGTGTGGGTCGGGC
CATCAGGGGCAAGACGGACTACGGCCTCATGGTCTTTGCCGACAAGCGGTTTGCCCGTGGGGACAAGCGGGGGAAGCTGCCCCGCTGGAT
CCAGGAGCACCTCACAGATGCCAACCTCAACCTGACCGTGGACGAGGGTGTCCAGGTGGCCAAGTACTTCCTGCGGCAGATGGCACAGCC
CTTCCACCGGGAGGATCAGCTGGGCCTGTCCCTGCTCAGCCTGGAGCAGCTAGAATCAGAGGAGACGCTGAAGAGGATAGAGCAGATTGC
TCAGCAGCTCTGAGTGGGGCGGGTGGGGCCATAAACGGTTCCTGGTGACTCCTGAGTCTTGCCTGGCCCTGGTTCCCAGCGGCGGTGGTG
CTAGAAGGTCTTATGAAGTCAGGTGACATTTCTCACTGTCACGTCCACAGCCTTTAATCGCAGGAGAAGGCAGCTATCCACCAGGTACCC
AGAGGCAAGGGGGGGCCAGGAGATGATAGACCCCCTCTCACCCCACCAGCCCATCCCTCCTGCACTGTTCCCAAGAAGCTGCGGCCAGCG
CAGTTCACTGGACGTTAGTGGGGGCTCAGGTCCTGGGTGCTGGCGCTGAGGGTCCGAGGGGCCTTGTCCAGGTGCCAGCTGGGAAACTGG
AGACAGGCACAGGGGATGGTTGGAGGGGAGGTGAGGGGCAAGTGTTACATCCACCCTCCAGCTCCAGGTCCAGCCTGGCAGCCAACTATC
CAACCCCCTCGCCTCTACCCCAAGTAAAACCCATCTTTGCTCCTGTCCTGGGTCTCTTCTGACACCAACCCACCACCTGCTGACTCCACC
ACTGGCCCGACCGCCCTGCCTTTGCCTCATCTCTGCACCTACCCACATGGCCTCCTCTATTTTTGACCCAGATGTCCCCCTCACCTGAGT
CCCAGGAGCCCTTGGAGCATCCACGTTCAGTGTGTTGAGTGACATGGCTCTCTTCATTCTGCAAAGAGGGCAGCAGGGAGGAAATGAGTG
AATCCAGGAGTGGCCCCCCTCCACGAGGGACCTTTCCAGCACAGGGTTTGATCTGTGTGTATCACAGGGGAGATGGGAGCCATGGAAGGT
TCTTGAGCAAGATGGGGGTGGGGGTGGGGTGGGCTGTGGATTCTGCTGATGTCAGGGCTCTTTGCCGACCTGATCAACACTCACCCGGCT
GCTCCTGCCGCCGCCTCGCCTCGGAGCCGGGAGACCAGCTTCTCACTTCCTCGCCTGATAGACTCACGGATCTTGGAGAGTGAGCTGCTG
CGGCGAAGGGCCTGGGGAGGGGCCGGGGATGCTGCTCAGTCCCCCAGGCCCATGCAGTCCCCACGCCCACCCCAGGAGCCGAAGCACAGC
CCATCCTCACCTGTTCTGCGTCACCAGCTGTGCCTGTGTTGGGGGCACCTAGGGGGAAAGATGGGGGACACTGAGATGGGGACATAGAGA
AGCCACCAGGAGGGAAGACAGACAGGGGCTAGGGGCTCACCGAGAGGGGCGGGTAGGTCCTCCTTGTGGAGGATTTCTTTGTACAGCTCT
TCCGCTTGTTGATACTTGTTCTGTTTCAGGTAGGCTGAGGCCTGCGGAGAAGGGAGTGTCTGGGAACTTTTCGGACCCCAGTTCCCAACA
CTGCATCCAGTCCCGCCTTTTTTTTTTTTTTTGTAGAGACAGGGGTCTTGGTATGTTGCCCAGGCTGGTCTTGAACTCCTAGCCTCAAGT
GATCCTCCTGCCTTGGCCTCCCAAAGTGTTGGGGTTACAAGCGTGAACCACCACGTCTGGCCCCACTTTCTAATGTGCTGACCTGGCCGT
ATCCTTCCCCTGCCTAAAGCCTTGCCCTGGGGCAGAGTGGGTTTGGAGCTCGGCCTTACTTCCTGCCCTGGGGATGGAGGACAGGCAGCC
TCCTGTTTCTGAGCCTGTCTGCTGTACTTTGGGCTGGTGGCATGGCCTCGGTGCCTCAGTCTTCCCACACGCAAAGTGGAGCGACAGCTC
CCACCTCATAGGGACGCTATAAGAACTAGCGATGTGGGGACCGGGCTAAGAGGGGAGCCGGCCACAGTGAGCTCAATAAATGTCTGCTGC

>44492_44492_9_LETM2-ERCC2_LETM2_chr8_38262024_ENST00000379957_ERCC2_chr19_45872405_ENST00000391945_length(amino acids)=1131AA_BP=406
MAFYSYNSVLAIARTRFPSHFVHPTCSSYSPSCAFLHLPDSHLNKTCMKNYESKKYSDPSQPGNTVLHPGTRLIQKLHTSTCWLQEVPGK
PQLEQATKHPQVTSPQATKETGMEIKEGKQSYRQKIMDELKYYYNGFYLLWIDAKVAARMVWRLLHGQVLTRRERRRLLRTCVDFFRLVP
FMVFLIVPFMEFLLPVFLKLFPEMLPSTFESESKKEEKQKKKMAVKLELAKFLQETMTEMARRNRAKMGDASTQLSSYVKQVQTGHKPST
KEIVRFSKLFEDQLALEHLDRPQLVALCKLLELQTFGTNNLLRFQLLMKLKSIKADDEIIAKEGVTALSVSELQAACRARGMRSLGLTEE
QLRQQLTEWQDLHLKENVPPSLLLLSRTFYLIDVKPKPIEIPLSGEGHGVLEMPSGTGKTVSLLALIMAYQRAYPLEVTKLIYCSRTVPE
IEKVIEELRKLLNFYEKQEGEKLPFLGLALSSRKNLCIHPEVTPLRFGKDVDGKCHSLTASYVRAQYQHDTSLPHCRFYEEFDAHGREVP
LPAGIYNLDDLKALGRRQGWCPYFLARYSILHANVVVYSYHYLLDPKIADLVSKELARKAVVVFDEAHNIDNVCIDSMSVNLTRRTLDRC
QGNLETLQKTVLRIKETDEQRLRDEYRRLVEGLREASAARETDAHLANPVLPDEVLQEAVPGSIRTAEHFLGFLRRLLEYVKWRLRVQHV
VQESPPAFLSGLAQRVCIQRKPLRFCAERLRSLLHTLEITDLADFSPLTLLANFATLVSTYAKGFTIIIEPFDDRTPTIANPILHFSCMD
ASLAIKPVFERFQSVIITSGTLSPLDIYPKILDFHPVTMATFTMTLARVCLCPMIIGRGNDQVAISSKFETREDIAVIRNYGNLLLEMSA
VVPDGIVAFFTSYQYMESTVASWYEQGILENIQRNKLLFIETQDGAETSVALEKYQEACENGRGAILLSVARGKVSEGIDFVHHYGRAVI
MFGVPYVYTQSRILKARLEYLRDQFQIRENDFLTFDAMRHAAQCVGRAIRGKTDYGLMVFADKRFARGDKRGKLPRWIQEHLTDANLNLT

--------------------------------------------------------------
>44492_44492_10_LETM2-ERCC2_LETM2_chr8_38262024_ENST00000379957_ERCC2_chr19_45872405_ENST00000485403_length(transcript)=2631nt_BP=1345nt
GTAGAGACTTGGCTTCGGGCCCTTCTAGCTTGGGGGTCCCGGGAAGGAGCTGGGAGGACCTAGGCGGCCGTTCCGCGGAGCCCGGCCGAG
GAGGTCCCTATGTTAACTACTTGAGACAAAAATAAATATGGCCTTCTACAGTTATAATTCAGTTCTGGCTATTGCTCGAACAAGATTCCC
TAGCCATTTTGTCCATCCTACCTGCTCTTCTTATTCCCCATCATGTGCATTTCTTCACTTGCCAGATTCCCATTTAAATAAGACATGTAT
GAAGAACTATGAGAGCAAGAAGTACTCGGATCCTAGTCAGCCAGGCAATACAGTACTTCACCCAGGAACTAGACTAATACAAAAGCTACA
CACATCCACTTGCTGGCTGCAAGAAGTTCCTGGCAAACCTCAGCTGGAGCAAGCCACAAAACATCCACAGGTGACAAGCCCTCAGGCCAC
AAAAGAAACTGGCATGGAGATTAAAGAAGGCAAACAATCTTATAGACAAAAAATCATGGATGAACTAAAATATTATTACAATGGATTCTA
CTTACTTTGGATTGACGCCAAAGTTGCTGCCAGAATGGTTTGGAGGCTGTTGCATGGACAGGTCCTGACCAGACGAGAGAGACGAAGGCT
GTTGAGAACTTGTGTTGATTTCTTCCGCCTGGTTCCATTTATGGTGTTCTTAATTGTACCCTTCATGGAATTCTTATTACCAGTGTTTCT
GAAACTCTTCCCAGAGATGTTGCCATCAACTTTTGAAAGTGAATCCAAAAAGGAAGAAAAACAGAAAAAGAAAATGGCTGTAAAGTTGGA
ACTAGCAAAATTTCTTCAAGAAACCATGACAGAAATGGCAAGGAGGAACAGAGCCAAGATGGGCGATGCCTCTACACAGCTCTCATCCTA
CGTGAAGCAGGTCCAGACAGGCCACAAGCCCAGCACAAAGGAGATAGTTCGCTTCTCCAAACTATTTGAGGACCAGCTGGCCCTGGAACA
CTTAGATCGCCCTCAGCTGGTTGCCCTTTGCAAACTGCTGGAATTGCAGACATTTGGAACCAACAACCTGCTCCGCTTTCAGCTCCTGAT
GAAACTGAAGTCTATAAAAGCAGATGATGAAATAATTGCCAAGGAAGGGGTGACAGCATTGAGTGTATCAGAACTACAGGCTGCCTGTAG
GGCCCGAGGGATGAGATCACTGGGTCTCACGGAGGAACAACTGCGACAACAGCTCACGGAGTGGCAGGACCTCCACCTGAAGGAGAACGT
CCCTCCTTCCCTTTTGCTCCTGTCCCGCACCTTCTACCTGATAGATGTGAAGCCCAAGCCGATTGAGATACCACTCAGTGGGGAGGGTCA
TGGAGTCCTGGAGATGCCCTCAGGCACCGGGAAGACAGTATCCCTGTTGGCCCTGATCATGGCATACCAGAGAGCATATCCGCTGGAGGT
GACCAAACTCATCTACTGCTCAAGAACTGTGCCAGAGATTGAGAAGGTGATTGAAGAGCTTCGAAAGTTGCTCAACTTCTATGAGAAGCA
GGAGGGCGAGAAGCTGCCGTTTCTGGGACTGGCTCTGAGCTCCCGCAAAAACTTGTGTATTCACCCTGAGGTGACACCCCTGCGCTTTGG
GAAGGACGTCGATGGGAAATGCCACAGCCTCACAGCCTCCTATGTGCGGGCGCAGTACCAGCATGACACCAGCCTGCCCCACTGCCGATT
CTATGAGGAATTTGATGCCCATGGGCGTGAGGTGCCCCTCCCCGCTGGCATCTACAACCTGGATGACCTGAAGGCCCTGGGGCGGCGCCA
GGGCTGGTGCCCATACTTCCTTGCTCGATACTCAATCCTGCATGCCAATGTGGTGGTTTATAGCTACCACTACCTCCTGGACCCCAAGAT
TGCAGACCTGGTGTCCAAGGAACTGGCCCGCAAGGCCGTCGTGGTCTTCGACGAGGCCCACAACATTGACAACGTCTGCATCGACTCCAT
GAGCGTCAACCTCACCCGCCGGACCCTTGACCGGTGCCAGGGCAACCTGGAGACCCTGCAGAAGACGGTGCTCAGGATCAAAGAGACAGA
CGAGCAGCGCCTGCGGGACGAGTACCGGCGTCTGGTGGAGGGGCTGCGGGAGGCCAGCGCCGCCCGGGAGACGGACGCCCACCTGGCCAA
CCCCGTGCTGCCCGACGAAGTGCTGCAGGAGGCAGTGCCTGGCTCCATCCGCACGGCCGAGCATTTCCTGGGCTTCCTGAGGCGGCTGCT
GGAGTACGTGAAGTGGCGGCTGCGTGTGCAGCATGTGGTGCAGGAGAGCCCGCCCGCCTTCCTGAGCGGCCTGGCCCAGCGCGTGTGCAT
CCAGCGCAAGCCCCTCAGATTCTGTGCTGAACGCCTCCGGTCCCTGCTGCATACTCTGGAGATCACCGACCTTGCTGACTTCTCCCCGCT
CACCCTCCTTGCTAACTTTGCCACCCTTGTCAGCACCTACGCCAAAGGCCAGGCTCAGCACTGTGGAAGCAGCAGGAACCAAAAAAGATC
TCATCCCTAACCCCCCAGAACTTATATTCCAGATGGGAAAACCAGTAGCAAAGATGCAGCCAAATAAACAAGGAAATAATTCCAGAAAGT

>44492_44492_10_LETM2-ERCC2_LETM2_chr8_38262024_ENST00000379957_ERCC2_chr19_45872405_ENST00000485403_length(amino acids)=800AA_BP=406
MAFYSYNSVLAIARTRFPSHFVHPTCSSYSPSCAFLHLPDSHLNKTCMKNYESKKYSDPSQPGNTVLHPGTRLIQKLHTSTCWLQEVPGK
PQLEQATKHPQVTSPQATKETGMEIKEGKQSYRQKIMDELKYYYNGFYLLWIDAKVAARMVWRLLHGQVLTRRERRRLLRTCVDFFRLVP
FMVFLIVPFMEFLLPVFLKLFPEMLPSTFESESKKEEKQKKKMAVKLELAKFLQETMTEMARRNRAKMGDASTQLSSYVKQVQTGHKPST
KEIVRFSKLFEDQLALEHLDRPQLVALCKLLELQTFGTNNLLRFQLLMKLKSIKADDEIIAKEGVTALSVSELQAACRARGMRSLGLTEE
QLRQQLTEWQDLHLKENVPPSLLLLSRTFYLIDVKPKPIEIPLSGEGHGVLEMPSGTGKTVSLLALIMAYQRAYPLEVTKLIYCSRTVPE
IEKVIEELRKLLNFYEKQEGEKLPFLGLALSSRKNLCIHPEVTPLRFGKDVDGKCHSLTASYVRAQYQHDTSLPHCRFYEEFDAHGREVP
LPAGIYNLDDLKALGRRQGWCPYFLARYSILHANVVVYSYHYLLDPKIADLVSKELARKAVVVFDEAHNIDNVCIDSMSVNLTRRTLDRC
QGNLETLQKTVLRIKETDEQRLRDEYRRLVEGLREASAARETDAHLANPVLPDEVLQEAVPGSIRTAEHFLGFLRRLLEYVKWRLRVQHV

--------------------------------------------------------------
>44492_44492_11_LETM2-ERCC2_LETM2_chr8_38262024_ENST00000523983_ERCC2_chr19_45872405_ENST00000221481_length(transcript)=1872nt_BP=1249nt
TAGCTTGGGGGTCCCGGGAAGGAGCTGGGAGGACCTAGGCGGCCGTTCCGCGGAGCCCGGCCGAGGAGGTCCCTATGTTAACTACTTGAG
ACAAAAATAAATATGGCCTTCTACAGTTATAATTCAGTTCTGGCTATTGCTCGAACAAGATTCCCATTTAAATAAGACATGTATGAAGAA
CTATGAGAGCAAGAAGTACTCGGATCCTAGTCAGCCAGGCAATACAGTACTTCACCCAGGAACTAGACTAATACAAAAGCTACACACATC
CACTTGCTGGCTGCAAGAAGTTCCTGGCAAACCTCAGCTGGAGCAAGCCACAAAACATCCACAGGTGACAAGCCCTCAGGCCACAAAAGA
AACTGGCATGGAGATTAAAGAAGGCAAACAATCTTATAGACAAAAAATCATGGATGAACTAAAATATTATTACAATGGATTCTACTTACT
TTGGATTGACGCCAAAGTTGCTGCCAGAATGGTTTGGAGGCTGTTGCATGGACAGGTCCTGACCAGACGAGAGAGACGAAGGCTGTTGAG
AACTTGTGTTGATTTCTTCCGCCTGGTTCCATTTATGGTGTTCTTAATTGTACCCTTCATGGAATTCTTATTACCAGTGTTTCTGAAACT
CTTCCCAGAGATGTTGCCATCAACTTTTGAAAGTGAATCCAAAAAGGAAGAAAAACAGAAAAAGAAAATGGCTGTAAAGTTGGAACTAGC
AAAATTTCTTCAAGAAACCATGACAGAAATGGCAAGGAGGAACAGAGCCAAGATGGGCGATGCCTCTACACAGCTCTCATCCTACGTGAA
GCAGGTCCAGACAGGCCACAAGCCCAGCACAAAGGAGATAGTTCGCTTCTCCAAACTATTTGAGGACCAGCTGGCCCTGGAACACTTAGA
TCGCCCTCAGCTGGTTGCCCTTTGCAAACTGCTGGAATTGCAGACATTTGGAACCAACAACCTGCTCCGCTTTCAGCTCCTGATGAAACT
GAAGTCTATAAAAGCAGATGATGAAATAATTGCCAAGGAAGGGGTGACAGCATTGAGTGTATCAGAACTACAGGCTGCCTGTAGGGCCCG
AGGGATGAGATCACTGGGTCTCACGGAGGAACAACTGCGACAACAGCTCACGGAGTGGCAGGACCTCCACCTGAAGGAGAACGTCCCTCC
TTCCCTTTTGCTCCTGTCCCGCACCTTCTACCTGATAGATGTGAAGCCCAAGCCGATTGAGATACCACTCAGTGGGGAGGGTCATGGAGT
CCTGGAGATGCCCTCAGGCACCGGGAAGACAGTATCCCTGTTGGCCCTGATCATGGCATACCAGAGAGCATATCCGCTGGAGGTGACCAA
ACTCATCTACTGCTCAAGAACTGTGCCAGAGATTGAGAAGGTGATTGAAGAGCTTCGAAAGTTGCTCAACTTCTATGAGAAGCAGGAGGG
CGAGAAGCTGCCGTTTCTGGGACTGGCTCTGAGCTCCCGCAAAAACTTGTGTATTCACCCTGAGACAACGTCTGCATCGACTCCATGAGC
GTCAACCTCACCCGCCGGACCCTTGACCGGTGCCAGGGCAACCTGGAGACCCTGCAGAAGACGGTGCTCAGGATCAAAGAGACAGACGAG
CAGCGCCTGCGGGACGAGTACCGGCGTCTGGTGGAGGGGCTGCGGGAGGCCAGCGCCGCCCGGGAGACGGACGCCCACCTGGCCAACCCC
GTGCTGCCCGACGAAGTGCTGCAGGAGGCAGTGCCTGGCTCCATCCGCACGGCCGAGCATTTCCTGGGCTTCCTGAGGCGGCTGCTGGAG

>44492_44492_11_LETM2-ERCC2_LETM2_chr8_38262024_ENST00000523983_ERCC2_chr19_45872405_ENST00000221481_length(amino acids)=463AA_BP=371
MLEQDSHLNKTCMKNYESKKYSDPSQPGNTVLHPGTRLIQKLHTSTCWLQEVPGKPQLEQATKHPQVTSPQATKETGMEIKEGKQSYRQK
IMDELKYYYNGFYLLWIDAKVAARMVWRLLHGQVLTRRERRRLLRTCVDFFRLVPFMVFLIVPFMEFLLPVFLKLFPEMLPSTFESESKK
EEKQKKKMAVKLELAKFLQETMTEMARRNRAKMGDASTQLSSYVKQVQTGHKPSTKEIVRFSKLFEDQLALEHLDRPQLVALCKLLELQT
FGTNNLLRFQLLMKLKSIKADDEIIAKEGVTALSVSELQAACRARGMRSLGLTEEQLRQQLTEWQDLHLKENVPPSLLLLSRTFYLIDVK
PKPIEIPLSGEGHGVLEMPSGTGKTVSLLALIMAYQRAYPLEVTKLIYCSRTVPEIEKVIEELRKLLNFYEKQEGEKLPFLGLALSSRKN

--------------------------------------------------------------
>44492_44492_12_LETM2-ERCC2_LETM2_chr8_38262024_ENST00000523983_ERCC2_chr19_45872405_ENST00000391940_length(transcript)=2434nt_BP=1249nt
TAGCTTGGGGGTCCCGGGAAGGAGCTGGGAGGACCTAGGCGGCCGTTCCGCGGAGCCCGGCCGAGGAGGTCCCTATGTTAACTACTTGAG
ACAAAAATAAATATGGCCTTCTACAGTTATAATTCAGTTCTGGCTATTGCTCGAACAAGATTCCCATTTAAATAAGACATGTATGAAGAA
CTATGAGAGCAAGAAGTACTCGGATCCTAGTCAGCCAGGCAATACAGTACTTCACCCAGGAACTAGACTAATACAAAAGCTACACACATC
CACTTGCTGGCTGCAAGAAGTTCCTGGCAAACCTCAGCTGGAGCAAGCCACAAAACATCCACAGGTGACAAGCCCTCAGGCCACAAAAGA
AACTGGCATGGAGATTAAAGAAGGCAAACAATCTTATAGACAAAAAATCATGGATGAACTAAAATATTATTACAATGGATTCTACTTACT
TTGGATTGACGCCAAAGTTGCTGCCAGAATGGTTTGGAGGCTGTTGCATGGACAGGTCCTGACCAGACGAGAGAGACGAAGGCTGTTGAG
AACTTGTGTTGATTTCTTCCGCCTGGTTCCATTTATGGTGTTCTTAATTGTACCCTTCATGGAATTCTTATTACCAGTGTTTCTGAAACT
CTTCCCAGAGATGTTGCCATCAACTTTTGAAAGTGAATCCAAAAAGGAAGAAAAACAGAAAAAGAAAATGGCTGTAAAGTTGGAACTAGC
AAAATTTCTTCAAGAAACCATGACAGAAATGGCAAGGAGGAACAGAGCCAAGATGGGCGATGCCTCTACACAGCTCTCATCCTACGTGAA
GCAGGTCCAGACAGGCCACAAGCCCAGCACAAAGGAGATAGTTCGCTTCTCCAAACTATTTGAGGACCAGCTGGCCCTGGAACACTTAGA
TCGCCCTCAGCTGGTTGCCCTTTGCAAACTGCTGGAATTGCAGACATTTGGAACCAACAACCTGCTCCGCTTTCAGCTCCTGATGAAACT
GAAGTCTATAAAAGCAGATGATGAAATAATTGCCAAGGAAGGGGTGACAGCATTGAGTGTATCAGAACTACAGGCTGCCTGTAGGGCCCG
AGGGATGAGATCACTGGGTCTCACGGAGGAACAACTGCGACAACAGCTCACGGAGTGGCAGGACCTCCACCTGAAGGAGAACGTCCCTCC
TTCCCTTTTGCTCCTGTCCCGCACCTTCTACCTGATAGATGTGAAGCCCAAGCCGATTGAGATACCACTCAGTGGGGAGGGTCATGGAGT
CCTGGAGATGCCCTCAGGCACCGGGAAGACAGTATCCCTGTTGGCCCTGATCATGGCATACCAGAGAGCATATCCGCTGGAGGTGACCAA
ACTCATCTACTGCTCAAGAACTGTGCCAGAGATTGAGAAGGTGATTGAAGAGCTTCGAAAGTTGCTCAACTTCTATGAGAAGCAGGAGGG
CGAGAAGCTGCCGTTTCTGGGACTGGCTCTGAGCTCCCGCAAAAACTTGTGTATTCACCCTGAGGTGACACCCCTGCGCTTTGGGAAGGA
CGTCGATGGGAAATGCCACAGCCTCACAGCCTCCTATGTGCGGGCGCAGTACCAGCATGACACCAGCCTGCCCCACTGCCGATTCTATGA
GGAATTTGATGCCCATGGGCGTGAGGTGCCCCTCCCCGCTGGCATCTACAACCTGGATGACCTGAAGGCCCTGGGGCGGCGCCAGGGCTG
GTGCCCATACTTCCTTGCTCGATACTCAATCCTGCATGCCAATGTGGTGGTTTATAGCTACCACTACCTCCTGGACCCCAAGATTGCAGA
CCTGGTGTCCAAGGAACTGGCCCGCAAGGCCGTCGTGGTCTTCGACGAGGCCCACAACATTGACAACGTCTGCATCGACTCCATGAGCGT
CAACCTCACCCGCCGGACCCTTGACCGGTGCCAGGGCAACCTGGAGACCCTGCAGAAGACGGTGCTCAGGATCAAAGAGACAGACGAGCA
GCGCCTGCGGGACGAGTACCGGCGTCTGGTGGAGGGGCTGCGGGAGGCCAGCGCCGCCCGGGAGACGGACGCCCACCTGGCCAACCCCGT
GCTGCCCGACGAAGTGCTGCAGGAGGCAGTGCCTGGCTCCATCCGCACGGCCGAGCATTTCCTGGGCTTCCTGAGGCGGCTGCTGGAGTA
CGTGAAGTGGCGGCTGCGTGTGCAGCATGTGGTGCAGGAGAGCCCGCCCGCCTTCCTGAGCGGCCTGGCCCAGCGCGTGTGCATCCAGCG
CAAGCCCCTCAGATTCTGTGCTGAACGCCTCCGGTCCCTGCTGCATACTCTGGAGATCACCGACCTTGCTGACTTCTCCCCGCTCACCCT
CCTTGCTAACTTTGCCACCCTTGTCAGCACCTACGCCAAAGGCCAGGCTCAGCACTGTGGAAGCAGCAGGAACCAAAAAAGATCTCATCC

>44492_44492_12_LETM2-ERCC2_LETM2_chr8_38262024_ENST00000523983_ERCC2_chr19_45872405_ENST00000391940_length(amino acids)=766AA_BP=371
MLEQDSHLNKTCMKNYESKKYSDPSQPGNTVLHPGTRLIQKLHTSTCWLQEVPGKPQLEQATKHPQVTSPQATKETGMEIKEGKQSYRQK
IMDELKYYYNGFYLLWIDAKVAARMVWRLLHGQVLTRRERRRLLRTCVDFFRLVPFMVFLIVPFMEFLLPVFLKLFPEMLPSTFESESKK
EEKQKKKMAVKLELAKFLQETMTEMARRNRAKMGDASTQLSSYVKQVQTGHKPSTKEIVRFSKLFEDQLALEHLDRPQLVALCKLLELQT
FGTNNLLRFQLLMKLKSIKADDEIIAKEGVTALSVSELQAACRARGMRSLGLTEEQLRQQLTEWQDLHLKENVPPSLLLLSRTFYLIDVK
PKPIEIPLSGEGHGVLEMPSGTGKTVSLLALIMAYQRAYPLEVTKLIYCSRTVPEIEKVIEELRKLLNFYEKQEGEKLPFLGLALSSRKN
LCIHPEVTPLRFGKDVDGKCHSLTASYVRAQYQHDTSLPHCRFYEEFDAHGREVPLPAGIYNLDDLKALGRRQGWCPYFLARYSILHANV
VVYSYHYLLDPKIADLVSKELARKAVVVFDEAHNIDNVCIDSMSVNLTRRTLDRCQGNLETLQKTVLRIKETDEQRLRDEYRRLVEGLRE
ASAARETDAHLANPVLPDEVLQEAVPGSIRTAEHFLGFLRRLLEYVKWRLRVQHVVQESPPAFLSGLAQRVCIQRKPLRFCAERLRSLLH

--------------------------------------------------------------
>44492_44492_13_LETM2-ERCC2_LETM2_chr8_38262024_ENST00000523983_ERCC2_chr19_45872405_ENST00000391944_length(transcript)=3219nt_BP=1249nt
TAGCTTGGGGGTCCCGGGAAGGAGCTGGGAGGACCTAGGCGGCCGTTCCGCGGAGCCCGGCCGAGGAGGTCCCTATGTTAACTACTTGAG
ACAAAAATAAATATGGCCTTCTACAGTTATAATTCAGTTCTGGCTATTGCTCGAACAAGATTCCCATTTAAATAAGACATGTATGAAGAA
CTATGAGAGCAAGAAGTACTCGGATCCTAGTCAGCCAGGCAATACAGTACTTCACCCAGGAACTAGACTAATACAAAAGCTACACACATC
CACTTGCTGGCTGCAAGAAGTTCCTGGCAAACCTCAGCTGGAGCAAGCCACAAAACATCCACAGGTGACAAGCCCTCAGGCCACAAAAGA
AACTGGCATGGAGATTAAAGAAGGCAAACAATCTTATAGACAAAAAATCATGGATGAACTAAAATATTATTACAATGGATTCTACTTACT
TTGGATTGACGCCAAAGTTGCTGCCAGAATGGTTTGGAGGCTGTTGCATGGACAGGTCCTGACCAGACGAGAGAGACGAAGGCTGTTGAG
AACTTGTGTTGATTTCTTCCGCCTGGTTCCATTTATGGTGTTCTTAATTGTACCCTTCATGGAATTCTTATTACCAGTGTTTCTGAAACT
CTTCCCAGAGATGTTGCCATCAACTTTTGAAAGTGAATCCAAAAAGGAAGAAAAACAGAAAAAGAAAATGGCTGTAAAGTTGGAACTAGC
AAAATTTCTTCAAGAAACCATGACAGAAATGGCAAGGAGGAACAGAGCCAAGATGGGCGATGCCTCTACACAGCTCTCATCCTACGTGAA
GCAGGTCCAGACAGGCCACAAGCCCAGCACAAAGGAGATAGTTCGCTTCTCCAAACTATTTGAGGACCAGCTGGCCCTGGAACACTTAGA
TCGCCCTCAGCTGGTTGCCCTTTGCAAACTGCTGGAATTGCAGACATTTGGAACCAACAACCTGCTCCGCTTTCAGCTCCTGATGAAACT
GAAGTCTATAAAAGCAGATGATGAAATAATTGCCAAGGAAGGGGTGACAGCATTGAGTGTATCAGAACTACAGGCTGCCTGTAGGGCCCG
AGGGATGAGATCACTGGGTCTCACGGAGGAACAACTGCGACAACAGCTCACGGAGTGGCAGGACCTCCACCTGAAGGAGAACGTCCCTCC
TTCCCTTTTGCTCCTGTCCCGCACCTTCTACCTGATAGATGTGAAGCCCAAGCCGATTGAGATACCACTCAGTGGGGAGGGTCATGGAGT
CCTGGAGATGCCCTCAGGCACCGGGAAGACAGTATCCCTGTTGGCCCTGATCATGGCATACCAGAGAGCATATCCGCTGGAGGTGACCAA
ACTCATCTACTGCTCAAGAACTGTGCCAGAGATTGAGAAGGTGATTGAAGAGCTTCGAAAGTTGCTCAACTTCTATGAGAAGCAGGAGGG
CGAGAAGCTGCCGTTTCTGGGACTGGCTCTGAGCTCCCGCAAAAACTTGTGTATTCACCCTGAGATCCTGCATGCCAATGTGGTGGTTTA
TAGCTACCACTACCTCCTGGACCCCAAGATTGCAGACCTGGTGTCCAAGGAACTGGCCCGCAAGGCCGTCGTGGTCTTCGACGAGGCCCA
CAACATTGACAACGTCTGCATCGACTCCATGAGCGTCAACCTCACCCGCCGGACCCTTGACCGGTGCCAGGGCAACCTGGAGACCCTGCA
GAAGACGGTGCTCAGGATCAAAGAGACAGACGAGCAGCGCCTGCGGGACGAGTACCGGCGTCTGGTGGAGGGGCTGCGGGAGGCCAGCGC
CGCCCGGGAGACGGACGCCCACCTGGCCAACCCCGTGCTGCCCGACGAAGTGCTGCAGGAGGCAGTGCCTGGCTCCATCCGCACGGCCGA
GCATTTCCTGGGCTTCCTGAGGCGGCTGCTGGAGTACGTGAAGTGGCGGCTGCGTGTGCAGCATGTGGTGCAGGAGAGCCCGCCCGCCTT
CCTGAGCGGCCTGGCCCAGCGCGTGTGCATCCAGCGCAAGCCCCTCAGATTCTGTGCTGAACGCCTCCGGTCCCTGCTGCATACTCTGGA
GATCACCGACCTTGCTGACTTCTCCCCGCTCACCCTCCTTGCTAACTTTGCCACCCTTGTCAGCACCTACGCCAAAGGCTTCACCATCAT
CATCGAGCCCTTTGACGACAGAACCCCGACCATTGCCAACCCCATCCTGCACTTCAGCTGCATGGACGCCTCGCTGGCCATCAAACCCGT
ATTTGAGCGTTTCCAGTCTGTCATCATCACATCTGGGACACTGTCCCCGCTGGACATCTACCCCAAGATCCTGGACTTCCACCCCGTCAC
CATGGCAACCTTCACCATGACGCTGGCACGGGTCTGCCTCTGCCCTATGATCATCGGCCGTGGCAATGACCAGGTGGCCATCAGCTCCAA
ATTTGAGACCCGGGAGGATATTGCTGTGATCCGGAACTATGGGAACCTCCTGCTGGAGATGTCCGCTGTGGTCCCTGATGGCATCGTGGC
CTTCTTCACCAGCTACCAGTACATGGAGAGCACCGTGGCCTCCTGGTATGAGCAGGGGATCCTTGAGAACATCCAGAGGAACAAGCTGCT
CTTTATTGAGACCCAGGATGGTGCCGAAACCAGTGTCGCCCTGGAGAAGTACCAGGAGGCCTGCGAGAATGGCCGCGGGGCCATCCTGCT
GTCAGTGGCCCGGGGCAAAGTGTCCGAGGGAATCGACTTTGTGCACCACTACGGGCGGGCCGTCATCATGTTTGGCGTCCCCTACGTCTA
CACACAGAGCCGCATTCTCAAGGCGCGGCTGGAATACCTGCGGGACCAGTTCCAGATTCGTGAGAATGACTTTCTTACCTTCGATGCCAT
GCGCCACGCGGCCCAGTGTGTGGGTCGGGCCATCAGGGGCAAGACGGACTACGGCCTCATGGTCTTTGCCGACAAGCGGTTTGCCCGTGG
GGACAAGCGGGGGAAGCTGCCCCGCTGGATCCAGGAGCACCTCACAGATGCCAACCTCAACCTGACCGTGGACGAGGGTGTCCAGGTGGC
CAAGTACTTCCTGCGGCAGATGGCACAGCCCTTCCACCGGGAGGATCAGCTGGGCCTGTCCCTGCTCAGCCTGGAGCAGCTAGAATCAGA

>44492_44492_13_LETM2-ERCC2_LETM2_chr8_38262024_ENST00000523983_ERCC2_chr19_45872405_ENST00000391944_length(amino acids)=1018AA_BP=371
MLEQDSHLNKTCMKNYESKKYSDPSQPGNTVLHPGTRLIQKLHTSTCWLQEVPGKPQLEQATKHPQVTSPQATKETGMEIKEGKQSYRQK
IMDELKYYYNGFYLLWIDAKVAARMVWRLLHGQVLTRRERRRLLRTCVDFFRLVPFMVFLIVPFMEFLLPVFLKLFPEMLPSTFESESKK
EEKQKKKMAVKLELAKFLQETMTEMARRNRAKMGDASTQLSSYVKQVQTGHKPSTKEIVRFSKLFEDQLALEHLDRPQLVALCKLLELQT
FGTNNLLRFQLLMKLKSIKADDEIIAKEGVTALSVSELQAACRARGMRSLGLTEEQLRQQLTEWQDLHLKENVPPSLLLLSRTFYLIDVK
PKPIEIPLSGEGHGVLEMPSGTGKTVSLLALIMAYQRAYPLEVTKLIYCSRTVPEIEKVIEELRKLLNFYEKQEGEKLPFLGLALSSRKN
LCIHPEILHANVVVYSYHYLLDPKIADLVSKELARKAVVVFDEAHNIDNVCIDSMSVNLTRRTLDRCQGNLETLQKTVLRIKETDEQRLR
DEYRRLVEGLREASAARETDAHLANPVLPDEVLQEAVPGSIRTAEHFLGFLRRLLEYVKWRLRVQHVVQESPPAFLSGLAQRVCIQRKPL
RFCAERLRSLLHTLEITDLADFSPLTLLANFATLVSTYAKGFTIIIEPFDDRTPTIANPILHFSCMDASLAIKPVFERFQSVIITSGTLS
PLDIYPKILDFHPVTMATFTMTLARVCLCPMIIGRGNDQVAISSKFETREDIAVIRNYGNLLLEMSAVVPDGIVAFFTSYQYMESTVASW
YEQGILENIQRNKLLFIETQDGAETSVALEKYQEACENGRGAILLSVARGKVSEGIDFVHHYGRAVIMFGVPYVYTQSRILKARLEYLRD
QFQIRENDFLTFDAMRHAAQCVGRAIRGKTDYGLMVFADKRFARGDKRGKLPRWIQEHLTDANLNLTVDEGVQVAKYFLRQMAQPFHRED

--------------------------------------------------------------
>44492_44492_14_LETM2-ERCC2_LETM2_chr8_38262024_ENST00000523983_ERCC2_chr19_45872405_ENST00000391945_length(transcript)=5219nt_BP=1249nt
TAGCTTGGGGGTCCCGGGAAGGAGCTGGGAGGACCTAGGCGGCCGTTCCGCGGAGCCCGGCCGAGGAGGTCCCTATGTTAACTACTTGAG
ACAAAAATAAATATGGCCTTCTACAGTTATAATTCAGTTCTGGCTATTGCTCGAACAAGATTCCCATTTAAATAAGACATGTATGAAGAA
CTATGAGAGCAAGAAGTACTCGGATCCTAGTCAGCCAGGCAATACAGTACTTCACCCAGGAACTAGACTAATACAAAAGCTACACACATC
CACTTGCTGGCTGCAAGAAGTTCCTGGCAAACCTCAGCTGGAGCAAGCCACAAAACATCCACAGGTGACAAGCCCTCAGGCCACAAAAGA
AACTGGCATGGAGATTAAAGAAGGCAAACAATCTTATAGACAAAAAATCATGGATGAACTAAAATATTATTACAATGGATTCTACTTACT
TTGGATTGACGCCAAAGTTGCTGCCAGAATGGTTTGGAGGCTGTTGCATGGACAGGTCCTGACCAGACGAGAGAGACGAAGGCTGTTGAG
AACTTGTGTTGATTTCTTCCGCCTGGTTCCATTTATGGTGTTCTTAATTGTACCCTTCATGGAATTCTTATTACCAGTGTTTCTGAAACT
CTTCCCAGAGATGTTGCCATCAACTTTTGAAAGTGAATCCAAAAAGGAAGAAAAACAGAAAAAGAAAATGGCTGTAAAGTTGGAACTAGC
AAAATTTCTTCAAGAAACCATGACAGAAATGGCAAGGAGGAACAGAGCCAAGATGGGCGATGCCTCTACACAGCTCTCATCCTACGTGAA
GCAGGTCCAGACAGGCCACAAGCCCAGCACAAAGGAGATAGTTCGCTTCTCCAAACTATTTGAGGACCAGCTGGCCCTGGAACACTTAGA
TCGCCCTCAGCTGGTTGCCCTTTGCAAACTGCTGGAATTGCAGACATTTGGAACCAACAACCTGCTCCGCTTTCAGCTCCTGATGAAACT
GAAGTCTATAAAAGCAGATGATGAAATAATTGCCAAGGAAGGGGTGACAGCATTGAGTGTATCAGAACTACAGGCTGCCTGTAGGGCCCG
AGGGATGAGATCACTGGGTCTCACGGAGGAACAACTGCGACAACAGCTCACGGAGTGGCAGGACCTCCACCTGAAGGAGAACGTCCCTCC
TTCCCTTTTGCTCCTGTCCCGCACCTTCTACCTGATAGATGTGAAGCCCAAGCCGATTGAGATACCACTCAGTGGGGAGGGTCATGGAGT
CCTGGAGATGCCCTCAGGCACCGGGAAGACAGTATCCCTGTTGGCCCTGATCATGGCATACCAGAGAGCATATCCGCTGGAGGTGACCAA
ACTCATCTACTGCTCAAGAACTGTGCCAGAGATTGAGAAGGTGATTGAAGAGCTTCGAAAGTTGCTCAACTTCTATGAGAAGCAGGAGGG
CGAGAAGCTGCCGTTTCTGGGACTGGCTCTGAGCTCCCGCAAAAACTTGTGTATTCACCCTGAGGTGACACCCCTGCGCTTTGGGAAGGA
CGTCGATGGGAAATGCCACAGCCTCACAGCCTCCTATGTGCGGGCGCAGTACCAGCATGACACCAGCCTGCCCCACTGCCGATTCTATGA
GGAATTTGATGCCCATGGGCGTGAGGTGCCCCTCCCCGCTGGCATCTACAACCTGGATGACCTGAAGGCCCTGGGGCGGCGCCAGGGCTG
GTGCCCATACTTCCTTGCTCGATACTCAATCCTGCATGCCAATGTGGTGGTTTATAGCTACCACTACCTCCTGGACCCCAAGATTGCAGA
CCTGGTGTCCAAGGAACTGGCCCGCAAGGCCGTCGTGGTCTTCGACGAGGCCCACAACATTGACAACGTCTGCATCGACTCCATGAGCGT
CAACCTCACCCGCCGGACCCTTGACCGGTGCCAGGGCAACCTGGAGACCCTGCAGAAGACGGTGCTCAGGATCAAAGAGACAGACGAGCA
GCGCCTGCGGGACGAGTACCGGCGTCTGGTGGAGGGGCTGCGGGAGGCCAGCGCCGCCCGGGAGACGGACGCCCACCTGGCCAACCCCGT
GCTGCCCGACGAAGTGCTGCAGGAGGCAGTGCCTGGCTCCATCCGCACGGCCGAGCATTTCCTGGGCTTCCTGAGGCGGCTGCTGGAGTA
CGTGAAGTGGCGGCTGCGTGTGCAGCATGTGGTGCAGGAGAGCCCGCCCGCCTTCCTGAGCGGCCTGGCCCAGCGCGTGTGCATCCAGCG
CAAGCCCCTCAGATTCTGTGCTGAACGCCTCCGGTCCCTGCTGCATACTCTGGAGATCACCGACCTTGCTGACTTCTCCCCGCTCACCCT
CCTTGCTAACTTTGCCACCCTTGTCAGCACCTACGCCAAAGGCTTCACCATCATCATCGAGCCCTTTGACGACAGAACCCCGACCATTGC
CAACCCCATCCTGCACTTCAGCTGCATGGACGCCTCGCTGGCCATCAAACCCGTATTTGAGCGTTTCCAGTCTGTCATCATCACATCTGG
GACACTGTCCCCGCTGGACATCTACCCCAAGATCCTGGACTTCCACCCCGTCACCATGGCAACCTTCACCATGACGCTGGCACGGGTCTG
CCTCTGCCCTATGATCATCGGCCGTGGCAATGACCAGGTGGCCATCAGCTCCAAATTTGAGACCCGGGAGGATATTGCTGTGATCCGGAA
CTATGGGAACCTCCTGCTGGAGATGTCCGCTGTGGTCCCTGATGGCATCGTGGCCTTCTTCACCAGCTACCAGTACATGGAGAGCACCGT
GGCCTCCTGGTATGAGCAGGGGATCCTTGAGAACATCCAGAGGAACAAGCTGCTCTTTATTGAGACCCAGGATGGTGCCGAAACCAGTGT
CGCCCTGGAGAAGTACCAGGAGGCCTGCGAGAATGGCCGCGGGGCCATCCTGCTGTCAGTGGCCCGGGGCAAAGTGTCCGAGGGAATCGA
CTTTGTGCACCACTACGGGCGGGCCGTCATCATGTTTGGCGTCCCCTACGTCTACACACAGAGCCGCATTCTCAAGGCGCGGCTGGAATA
CCTGCGGGACCAGTTCCAGATTCGTGAGAATGACTTTCTTACCTTCGATGCCATGCGCCACGCGGCCCAGTGTGTGGGTCGGGCCATCAG
GGGCAAGACGGACTACGGCCTCATGGTCTTTGCCGACAAGCGGTTTGCCCGTGGGGACAAGCGGGGGAAGCTGCCCCGCTGGATCCAGGA
GCACCTCACAGATGCCAACCTCAACCTGACCGTGGACGAGGGTGTCCAGGTGGCCAAGTACTTCCTGCGGCAGATGGCACAGCCCTTCCA
CCGGGAGGATCAGCTGGGCCTGTCCCTGCTCAGCCTGGAGCAGCTAGAATCAGAGGAGACGCTGAAGAGGATAGAGCAGATTGCTCAGCA
GCTCTGAGTGGGGCGGGTGGGGCCATAAACGGTTCCTGGTGACTCCTGAGTCTTGCCTGGCCCTGGTTCCCAGCGGCGGTGGTGCTAGAA
GGTCTTATGAAGTCAGGTGACATTTCTCACTGTCACGTCCACAGCCTTTAATCGCAGGAGAAGGCAGCTATCCACCAGGTACCCAGAGGC
AAGGGGGGGCCAGGAGATGATAGACCCCCTCTCACCCCACCAGCCCATCCCTCCTGCACTGTTCCCAAGAAGCTGCGGCCAGCGCAGTTC
ACTGGACGTTAGTGGGGGCTCAGGTCCTGGGTGCTGGCGCTGAGGGTCCGAGGGGCCTTGTCCAGGTGCCAGCTGGGAAACTGGAGACAG
GCACAGGGGATGGTTGGAGGGGAGGTGAGGGGCAAGTGTTACATCCACCCTCCAGCTCCAGGTCCAGCCTGGCAGCCAACTATCCAACCC
CCTCGCCTCTACCCCAAGTAAAACCCATCTTTGCTCCTGTCCTGGGTCTCTTCTGACACCAACCCACCACCTGCTGACTCCACCACTGGC
CCGACCGCCCTGCCTTTGCCTCATCTCTGCACCTACCCACATGGCCTCCTCTATTTTTGACCCAGATGTCCCCCTCACCTGAGTCCCAGG
AGCCCTTGGAGCATCCACGTTCAGTGTGTTGAGTGACATGGCTCTCTTCATTCTGCAAAGAGGGCAGCAGGGAGGAAATGAGTGAATCCA
GGAGTGGCCCCCCTCCACGAGGGACCTTTCCAGCACAGGGTTTGATCTGTGTGTATCACAGGGGAGATGGGAGCCATGGAAGGTTCTTGA
GCAAGATGGGGGTGGGGGTGGGGTGGGCTGTGGATTCTGCTGATGTCAGGGCTCTTTGCCGACCTGATCAACACTCACCCGGCTGCTCCT
GCCGCCGCCTCGCCTCGGAGCCGGGAGACCAGCTTCTCACTTCCTCGCCTGATAGACTCACGGATCTTGGAGAGTGAGCTGCTGCGGCGA
AGGGCCTGGGGAGGGGCCGGGGATGCTGCTCAGTCCCCCAGGCCCATGCAGTCCCCACGCCCACCCCAGGAGCCGAAGCACAGCCCATCC
TCACCTGTTCTGCGTCACCAGCTGTGCCTGTGTTGGGGGCACCTAGGGGGAAAGATGGGGGACACTGAGATGGGGACATAGAGAAGCCAC
CAGGAGGGAAGACAGACAGGGGCTAGGGGCTCACCGAGAGGGGCGGGTAGGTCCTCCTTGTGGAGGATTTCTTTGTACAGCTCTTCCGCT
TGTTGATACTTGTTCTGTTTCAGGTAGGCTGAGGCCTGCGGAGAAGGGAGTGTCTGGGAACTTTTCGGACCCCAGTTCCCAACACTGCAT
CCAGTCCCGCCTTTTTTTTTTTTTTTGTAGAGACAGGGGTCTTGGTATGTTGCCCAGGCTGGTCTTGAACTCCTAGCCTCAAGTGATCCT
CCTGCCTTGGCCTCCCAAAGTGTTGGGGTTACAAGCGTGAACCACCACGTCTGGCCCCACTTTCTAATGTGCTGACCTGGCCGTATCCTT
CCCCTGCCTAAAGCCTTGCCCTGGGGCAGAGTGGGTTTGGAGCTCGGCCTTACTTCCTGCCCTGGGGATGGAGGACAGGCAGCCTCCTGT
TTCTGAGCCTGTCTGCTGTACTTTGGGCTGGTGGCATGGCCTCGGTGCCTCAGTCTTCCCACACGCAAAGTGGAGCGACAGCTCCCACCT

>44492_44492_14_LETM2-ERCC2_LETM2_chr8_38262024_ENST00000523983_ERCC2_chr19_45872405_ENST00000391945_length(amino acids)=1096AA_BP=371
MLEQDSHLNKTCMKNYESKKYSDPSQPGNTVLHPGTRLIQKLHTSTCWLQEVPGKPQLEQATKHPQVTSPQATKETGMEIKEGKQSYRQK
IMDELKYYYNGFYLLWIDAKVAARMVWRLLHGQVLTRRERRRLLRTCVDFFRLVPFMVFLIVPFMEFLLPVFLKLFPEMLPSTFESESKK
EEKQKKKMAVKLELAKFLQETMTEMARRNRAKMGDASTQLSSYVKQVQTGHKPSTKEIVRFSKLFEDQLALEHLDRPQLVALCKLLELQT
FGTNNLLRFQLLMKLKSIKADDEIIAKEGVTALSVSELQAACRARGMRSLGLTEEQLRQQLTEWQDLHLKENVPPSLLLLSRTFYLIDVK
PKPIEIPLSGEGHGVLEMPSGTGKTVSLLALIMAYQRAYPLEVTKLIYCSRTVPEIEKVIEELRKLLNFYEKQEGEKLPFLGLALSSRKN
LCIHPEVTPLRFGKDVDGKCHSLTASYVRAQYQHDTSLPHCRFYEEFDAHGREVPLPAGIYNLDDLKALGRRQGWCPYFLARYSILHANV
VVYSYHYLLDPKIADLVSKELARKAVVVFDEAHNIDNVCIDSMSVNLTRRTLDRCQGNLETLQKTVLRIKETDEQRLRDEYRRLVEGLRE
ASAARETDAHLANPVLPDEVLQEAVPGSIRTAEHFLGFLRRLLEYVKWRLRVQHVVQESPPAFLSGLAQRVCIQRKPLRFCAERLRSLLH
TLEITDLADFSPLTLLANFATLVSTYAKGFTIIIEPFDDRTPTIANPILHFSCMDASLAIKPVFERFQSVIITSGTLSPLDIYPKILDFH
PVTMATFTMTLARVCLCPMIIGRGNDQVAISSKFETREDIAVIRNYGNLLLEMSAVVPDGIVAFFTSYQYMESTVASWYEQGILENIQRN
KLLFIETQDGAETSVALEKYQEACENGRGAILLSVARGKVSEGIDFVHHYGRAVIMFGVPYVYTQSRILKARLEYLRDQFQIRENDFLTF
DAMRHAAQCVGRAIRGKTDYGLMVFADKRFARGDKRGKLPRWIQEHLTDANLNLTVDEGVQVAKYFLRQMAQPFHREDQLGLSLLSLEQL

--------------------------------------------------------------
>44492_44492_15_LETM2-ERCC2_LETM2_chr8_38262024_ENST00000523983_ERCC2_chr19_45872405_ENST00000485403_length(transcript)=2535nt_BP=1249nt
TAGCTTGGGGGTCCCGGGAAGGAGCTGGGAGGACCTAGGCGGCCGTTCCGCGGAGCCCGGCCGAGGAGGTCCCTATGTTAACTACTTGAG
ACAAAAATAAATATGGCCTTCTACAGTTATAATTCAGTTCTGGCTATTGCTCGAACAAGATTCCCATTTAAATAAGACATGTATGAAGAA
CTATGAGAGCAAGAAGTACTCGGATCCTAGTCAGCCAGGCAATACAGTACTTCACCCAGGAACTAGACTAATACAAAAGCTACACACATC
CACTTGCTGGCTGCAAGAAGTTCCTGGCAAACCTCAGCTGGAGCAAGCCACAAAACATCCACAGGTGACAAGCCCTCAGGCCACAAAAGA
AACTGGCATGGAGATTAAAGAAGGCAAACAATCTTATAGACAAAAAATCATGGATGAACTAAAATATTATTACAATGGATTCTACTTACT
TTGGATTGACGCCAAAGTTGCTGCCAGAATGGTTTGGAGGCTGTTGCATGGACAGGTCCTGACCAGACGAGAGAGACGAAGGCTGTTGAG
AACTTGTGTTGATTTCTTCCGCCTGGTTCCATTTATGGTGTTCTTAATTGTACCCTTCATGGAATTCTTATTACCAGTGTTTCTGAAACT
CTTCCCAGAGATGTTGCCATCAACTTTTGAAAGTGAATCCAAAAAGGAAGAAAAACAGAAAAAGAAAATGGCTGTAAAGTTGGAACTAGC
AAAATTTCTTCAAGAAACCATGACAGAAATGGCAAGGAGGAACAGAGCCAAGATGGGCGATGCCTCTACACAGCTCTCATCCTACGTGAA
GCAGGTCCAGACAGGCCACAAGCCCAGCACAAAGGAGATAGTTCGCTTCTCCAAACTATTTGAGGACCAGCTGGCCCTGGAACACTTAGA
TCGCCCTCAGCTGGTTGCCCTTTGCAAACTGCTGGAATTGCAGACATTTGGAACCAACAACCTGCTCCGCTTTCAGCTCCTGATGAAACT
GAAGTCTATAAAAGCAGATGATGAAATAATTGCCAAGGAAGGGGTGACAGCATTGAGTGTATCAGAACTACAGGCTGCCTGTAGGGCCCG
AGGGATGAGATCACTGGGTCTCACGGAGGAACAACTGCGACAACAGCTCACGGAGTGGCAGGACCTCCACCTGAAGGAGAACGTCCCTCC
TTCCCTTTTGCTCCTGTCCCGCACCTTCTACCTGATAGATGTGAAGCCCAAGCCGATTGAGATACCACTCAGTGGGGAGGGTCATGGAGT
CCTGGAGATGCCCTCAGGCACCGGGAAGACAGTATCCCTGTTGGCCCTGATCATGGCATACCAGAGAGCATATCCGCTGGAGGTGACCAA
ACTCATCTACTGCTCAAGAACTGTGCCAGAGATTGAGAAGGTGATTGAAGAGCTTCGAAAGTTGCTCAACTTCTATGAGAAGCAGGAGGG
CGAGAAGCTGCCGTTTCTGGGACTGGCTCTGAGCTCCCGCAAAAACTTGTGTATTCACCCTGAGGTGACACCCCTGCGCTTTGGGAAGGA
CGTCGATGGGAAATGCCACAGCCTCACAGCCTCCTATGTGCGGGCGCAGTACCAGCATGACACCAGCCTGCCCCACTGCCGATTCTATGA
GGAATTTGATGCCCATGGGCGTGAGGTGCCCCTCCCCGCTGGCATCTACAACCTGGATGACCTGAAGGCCCTGGGGCGGCGCCAGGGCTG
GTGCCCATACTTCCTTGCTCGATACTCAATCCTGCATGCCAATGTGGTGGTTTATAGCTACCACTACCTCCTGGACCCCAAGATTGCAGA
CCTGGTGTCCAAGGAACTGGCCCGCAAGGCCGTCGTGGTCTTCGACGAGGCCCACAACATTGACAACGTCTGCATCGACTCCATGAGCGT
CAACCTCACCCGCCGGACCCTTGACCGGTGCCAGGGCAACCTGGAGACCCTGCAGAAGACGGTGCTCAGGATCAAAGAGACAGACGAGCA
GCGCCTGCGGGACGAGTACCGGCGTCTGGTGGAGGGGCTGCGGGAGGCCAGCGCCGCCCGGGAGACGGACGCCCACCTGGCCAACCCCGT
GCTGCCCGACGAAGTGCTGCAGGAGGCAGTGCCTGGCTCCATCCGCACGGCCGAGCATTTCCTGGGCTTCCTGAGGCGGCTGCTGGAGTA
CGTGAAGTGGCGGCTGCGTGTGCAGCATGTGGTGCAGGAGAGCCCGCCCGCCTTCCTGAGCGGCCTGGCCCAGCGCGTGTGCATCCAGCG
CAAGCCCCTCAGATTCTGTGCTGAACGCCTCCGGTCCCTGCTGCATACTCTGGAGATCACCGACCTTGCTGACTTCTCCCCGCTCACCCT
CCTTGCTAACTTTGCCACCCTTGTCAGCACCTACGCCAAAGGCCAGGCTCAGCACTGTGGAAGCAGCAGGAACCAAAAAAGATCTCATCC
CTAACCCCCCAGAACTTATATTCCAGATGGGAAAACCAGTAGCAAAGATGCAGCCAAATAAACAAGGAAATAATTCCAGAAAGTGACAGT

>44492_44492_15_LETM2-ERCC2_LETM2_chr8_38262024_ENST00000523983_ERCC2_chr19_45872405_ENST00000485403_length(amino acids)=765AA_BP=371
MLEQDSHLNKTCMKNYESKKYSDPSQPGNTVLHPGTRLIQKLHTSTCWLQEVPGKPQLEQATKHPQVTSPQATKETGMEIKEGKQSYRQK
IMDELKYYYNGFYLLWIDAKVAARMVWRLLHGQVLTRRERRRLLRTCVDFFRLVPFMVFLIVPFMEFLLPVFLKLFPEMLPSTFESESKK
EEKQKKKMAVKLELAKFLQETMTEMARRNRAKMGDASTQLSSYVKQVQTGHKPSTKEIVRFSKLFEDQLALEHLDRPQLVALCKLLELQT
FGTNNLLRFQLLMKLKSIKADDEIIAKEGVTALSVSELQAACRARGMRSLGLTEEQLRQQLTEWQDLHLKENVPPSLLLLSRTFYLIDVK
PKPIEIPLSGEGHGVLEMPSGTGKTVSLLALIMAYQRAYPLEVTKLIYCSRTVPEIEKVIEELRKLLNFYEKQEGEKLPFLGLALSSRKN
LCIHPEVTPLRFGKDVDGKCHSLTASYVRAQYQHDTSLPHCRFYEEFDAHGREVPLPAGIYNLDDLKALGRRQGWCPYFLARYSILHANV
VVYSYHYLLDPKIADLVSKELARKAVVVFDEAHNIDNVCIDSMSVNLTRRTLDRCQGNLETLQKTVLRIKETDEQRLRDEYRRLVEGLRE
ASAARETDAHLANPVLPDEVLQEAVPGSIRTAEHFLGFLRRLLEYVKWRLRVQHVVQESPPAFLSGLAQRVCIQRKPLRFCAERLRSLLH

--------------------------------------------------------------
>44492_44492_16_LETM2-ERCC2_LETM2_chr8_38262024_ENST00000524874_ERCC2_chr19_45872405_ENST00000221481_length(transcript)=1824nt_BP=1201nt
GTAGAGACTTGGCTTCGGGCCCTTCTAGCTTGGGGGTCCCGGGAAGGAGCTGGGAGGACCTAGGCGGCCGTTCCGCGGAGCCCGGCCGAG
GAGGTCCCTATGTTAACTACTTGAGACAAAAATAAATATGGCCTTCTACAGTTATAATTCAGTTCTGGCTATTGCTCGAACAAGATTCCC
TAGCCATTTTGTCCATCCTACCTGCTCTTCTTATTCCCCATCATGTGCATTTCTTCACTTGCCAGATTCCCATTTAAATAAGACATGTAT
GAAGAACTATGAGAGCAAGAAGTACTCGGATCCTAGTCAGCCAGGCAATACAGTACTTCACCCAGGAACTAGACTAATACAAAAGCTACA
CACATCCACTTGCTGGCTGCAAGAAGTTCCTGGCAAACCTCAGCTGGAGCAAGCCACAAAACATCCACAGGTGACAAGCCCTCAGGCCAC
AAAAGAAACTGGCATGGAGATTAAAGAAGGCAAACAATCTTATAGACAAAAAATCATGGATGAACTAAAATATTATTACAATGGATTCTA
CTTACTTTGGATTGACGCCAAAGTTGCTGCCAGAATGGTTTGGAGGCTGTTGCATGGACAGGTCCTGACCAGACGAGAGAGACGAAGGGA
AGAAAAACAGAAAAAGAAAATGGCTGTAAAGTTGGAACTAGCAAAATTTCTTCAAGAAACCATGACAGAAATGGCAAGGAGGAACAGAGC
CAAGATGGGCGATGCCTCTACACAGCTCTCATCCTACGTGAAGCAGGTCCAGACAGGCCACAAGCCCAGCACAAAGGAGATAGTTCGCTT
CTCCAAACTATTTGAGGACCAGCTGGCCCTGGAACACTTAGATCGCCCTCAGCTGGTTGCCCTTTGCAAACTGCTGGAATTGCAGACATT
TGGAACCAACAACCTGCTCCGCTTTCAGCTCCTGATGAAACTGAAGTCTATAAAAGCAGATGATGAAATAATTGCCAAGGAAGGGGTGAC
AGCATTGAGTGTATCAGAACTACAGGCTGCCTGTAGGGCCCGAGGGATGAGATCACTGGGTCTCACGGAGGAACAACTGCGACAACAGCT
CACGGAGTGGCAGGACCTCCACCTGAAGGAGAACGTCCCTCCTTCCCTTTTGCTCCTGTCCCGCACCTTCTACCTGATAGATGTGAAGCC
CAAGCCGATTGAGATACCACTCAGTGGGGAGGGTCATGGAGTCCTGGAGATGCCCTCAGGCACCGGGAAGACAGTATCCCTGTTGGCCCT
GATCATGGCATACCAGAGAGCATATCCGCTGGAGGTGACCAAACTCATCTACTGCTCAAGAACTGTGCCAGAGATTGAGAAGGTGATTGA
AGAGCTTCGAAAGTTGCTCAACTTCTATGAGAAGCAGGAGGGCGAGAAGCTGCCGTTTCTGGGACTGGCTCTGAGCTCCCGCAAAAACTT
GTGTATTCACCCTGAGACAACGTCTGCATCGACTCCATGAGCGTCAACCTCACCCGCCGGACCCTTGACCGGTGCCAGGGCAACCTGGAG
ACCCTGCAGAAGACGGTGCTCAGGATCAAAGAGACAGACGAGCAGCGCCTGCGGGACGAGTACCGGCGTCTGGTGGAGGGGCTGCGGGAG
GCCAGCGCCGCCCGGGAGACGGACGCCCACCTGGCCAACCCCGTGCTGCCCGACGAAGTGCTGCAGGAGGCAGTGCCTGGCTCCATCCGC
ACGGCCGAGCATTTCCTGGGCTTCCTGAGGCGGCTGCTGGAGTACGTGAAGTGGCGGCTGCGTGTGCAGCATGTGGTGCAGGAGAGCCCG

>44492_44492_16_LETM2-ERCC2_LETM2_chr8_38262024_ENST00000524874_ERCC2_chr19_45872405_ENST00000221481_length(amino acids)=450AA_BP=358
MAFYSYNSVLAIARTRFPSHFVHPTCSSYSPSCAFLHLPDSHLNKTCMKNYESKKYSDPSQPGNTVLHPGTRLIQKLHTSTCWLQEVPGK
PQLEQATKHPQVTSPQATKETGMEIKEGKQSYRQKIMDELKYYYNGFYLLWIDAKVAARMVWRLLHGQVLTRRERRREEKQKKKMAVKLE
LAKFLQETMTEMARRNRAKMGDASTQLSSYVKQVQTGHKPSTKEIVRFSKLFEDQLALEHLDRPQLVALCKLLELQTFGTNNLLRFQLLM
KLKSIKADDEIIAKEGVTALSVSELQAACRARGMRSLGLTEEQLRQQLTEWQDLHLKENVPPSLLLLSRTFYLIDVKPKPIEIPLSGEGH
GVLEMPSGTGKTVSLLALIMAYQRAYPLEVTKLIYCSRTVPEIEKVIEELRKLLNFYEKQEGEKLPFLGLALSSRKNLCIHPETTSASTP

--------------------------------------------------------------
>44492_44492_17_LETM2-ERCC2_LETM2_chr8_38262024_ENST00000524874_ERCC2_chr19_45872405_ENST00000391940_length(transcript)=2386nt_BP=1201nt
GTAGAGACTTGGCTTCGGGCCCTTCTAGCTTGGGGGTCCCGGGAAGGAGCTGGGAGGACCTAGGCGGCCGTTCCGCGGAGCCCGGCCGAG
GAGGTCCCTATGTTAACTACTTGAGACAAAAATAAATATGGCCTTCTACAGTTATAATTCAGTTCTGGCTATTGCTCGAACAAGATTCCC
TAGCCATTTTGTCCATCCTACCTGCTCTTCTTATTCCCCATCATGTGCATTTCTTCACTTGCCAGATTCCCATTTAAATAAGACATGTAT
GAAGAACTATGAGAGCAAGAAGTACTCGGATCCTAGTCAGCCAGGCAATACAGTACTTCACCCAGGAACTAGACTAATACAAAAGCTACA
CACATCCACTTGCTGGCTGCAAGAAGTTCCTGGCAAACCTCAGCTGGAGCAAGCCACAAAACATCCACAGGTGACAAGCCCTCAGGCCAC
AAAAGAAACTGGCATGGAGATTAAAGAAGGCAAACAATCTTATAGACAAAAAATCATGGATGAACTAAAATATTATTACAATGGATTCTA
CTTACTTTGGATTGACGCCAAAGTTGCTGCCAGAATGGTTTGGAGGCTGTTGCATGGACAGGTCCTGACCAGACGAGAGAGACGAAGGGA
AGAAAAACAGAAAAAGAAAATGGCTGTAAAGTTGGAACTAGCAAAATTTCTTCAAGAAACCATGACAGAAATGGCAAGGAGGAACAGAGC
CAAGATGGGCGATGCCTCTACACAGCTCTCATCCTACGTGAAGCAGGTCCAGACAGGCCACAAGCCCAGCACAAAGGAGATAGTTCGCTT
CTCCAAACTATTTGAGGACCAGCTGGCCCTGGAACACTTAGATCGCCCTCAGCTGGTTGCCCTTTGCAAACTGCTGGAATTGCAGACATT
TGGAACCAACAACCTGCTCCGCTTTCAGCTCCTGATGAAACTGAAGTCTATAAAAGCAGATGATGAAATAATTGCCAAGGAAGGGGTGAC
AGCATTGAGTGTATCAGAACTACAGGCTGCCTGTAGGGCCCGAGGGATGAGATCACTGGGTCTCACGGAGGAACAACTGCGACAACAGCT
CACGGAGTGGCAGGACCTCCACCTGAAGGAGAACGTCCCTCCTTCCCTTTTGCTCCTGTCCCGCACCTTCTACCTGATAGATGTGAAGCC
CAAGCCGATTGAGATACCACTCAGTGGGGAGGGTCATGGAGTCCTGGAGATGCCCTCAGGCACCGGGAAGACAGTATCCCTGTTGGCCCT
GATCATGGCATACCAGAGAGCATATCCGCTGGAGGTGACCAAACTCATCTACTGCTCAAGAACTGTGCCAGAGATTGAGAAGGTGATTGA
AGAGCTTCGAAAGTTGCTCAACTTCTATGAGAAGCAGGAGGGCGAGAAGCTGCCGTTTCTGGGACTGGCTCTGAGCTCCCGCAAAAACTT
GTGTATTCACCCTGAGGTGACACCCCTGCGCTTTGGGAAGGACGTCGATGGGAAATGCCACAGCCTCACAGCCTCCTATGTGCGGGCGCA
GTACCAGCATGACACCAGCCTGCCCCACTGCCGATTCTATGAGGAATTTGATGCCCATGGGCGTGAGGTGCCCCTCCCCGCTGGCATCTA
CAACCTGGATGACCTGAAGGCCCTGGGGCGGCGCCAGGGCTGGTGCCCATACTTCCTTGCTCGATACTCAATCCTGCATGCCAATGTGGT
GGTTTATAGCTACCACTACCTCCTGGACCCCAAGATTGCAGACCTGGTGTCCAAGGAACTGGCCCGCAAGGCCGTCGTGGTCTTCGACGA
GGCCCACAACATTGACAACGTCTGCATCGACTCCATGAGCGTCAACCTCACCCGCCGGACCCTTGACCGGTGCCAGGGCAACCTGGAGAC
CCTGCAGAAGACGGTGCTCAGGATCAAAGAGACAGACGAGCAGCGCCTGCGGGACGAGTACCGGCGTCTGGTGGAGGGGCTGCGGGAGGC
CAGCGCCGCCCGGGAGACGGACGCCCACCTGGCCAACCCCGTGCTGCCCGACGAAGTGCTGCAGGAGGCAGTGCCTGGCTCCATCCGCAC
GGCCGAGCATTTCCTGGGCTTCCTGAGGCGGCTGCTGGAGTACGTGAAGTGGCGGCTGCGTGTGCAGCATGTGGTGCAGGAGAGCCCGCC
CGCCTTCCTGAGCGGCCTGGCCCAGCGCGTGTGCATCCAGCGCAAGCCCCTCAGATTCTGTGCTGAACGCCTCCGGTCCCTGCTGCATAC
TCTGGAGATCACCGACCTTGCTGACTTCTCCCCGCTCACCCTCCTTGCTAACTTTGCCACCCTTGTCAGCACCTACGCCAAAGGCCAGGC

>44492_44492_17_LETM2-ERCC2_LETM2_chr8_38262024_ENST00000524874_ERCC2_chr19_45872405_ENST00000391940_length(amino acids)=753AA_BP=358
MAFYSYNSVLAIARTRFPSHFVHPTCSSYSPSCAFLHLPDSHLNKTCMKNYESKKYSDPSQPGNTVLHPGTRLIQKLHTSTCWLQEVPGK
PQLEQATKHPQVTSPQATKETGMEIKEGKQSYRQKIMDELKYYYNGFYLLWIDAKVAARMVWRLLHGQVLTRRERRREEKQKKKMAVKLE
LAKFLQETMTEMARRNRAKMGDASTQLSSYVKQVQTGHKPSTKEIVRFSKLFEDQLALEHLDRPQLVALCKLLELQTFGTNNLLRFQLLM
KLKSIKADDEIIAKEGVTALSVSELQAACRARGMRSLGLTEEQLRQQLTEWQDLHLKENVPPSLLLLSRTFYLIDVKPKPIEIPLSGEGH
GVLEMPSGTGKTVSLLALIMAYQRAYPLEVTKLIYCSRTVPEIEKVIEELRKLLNFYEKQEGEKLPFLGLALSSRKNLCIHPEVTPLRFG
KDVDGKCHSLTASYVRAQYQHDTSLPHCRFYEEFDAHGREVPLPAGIYNLDDLKALGRRQGWCPYFLARYSILHANVVVYSYHYLLDPKI
ADLVSKELARKAVVVFDEAHNIDNVCIDSMSVNLTRRTLDRCQGNLETLQKTVLRIKETDEQRLRDEYRRLVEGLREASAARETDAHLAN
PVLPDEVLQEAVPGSIRTAEHFLGFLRRLLEYVKWRLRVQHVVQESPPAFLSGLAQRVCIQRKPLRFCAERLRSLLHTLEITDLADFSPL

--------------------------------------------------------------
>44492_44492_18_LETM2-ERCC2_LETM2_chr8_38262024_ENST00000524874_ERCC2_chr19_45872405_ENST00000391944_length(transcript)=3171nt_BP=1201nt
GTAGAGACTTGGCTTCGGGCCCTTCTAGCTTGGGGGTCCCGGGAAGGAGCTGGGAGGACCTAGGCGGCCGTTCCGCGGAGCCCGGCCGAG
GAGGTCCCTATGTTAACTACTTGAGACAAAAATAAATATGGCCTTCTACAGTTATAATTCAGTTCTGGCTATTGCTCGAACAAGATTCCC
TAGCCATTTTGTCCATCCTACCTGCTCTTCTTATTCCCCATCATGTGCATTTCTTCACTTGCCAGATTCCCATTTAAATAAGACATGTAT
GAAGAACTATGAGAGCAAGAAGTACTCGGATCCTAGTCAGCCAGGCAATACAGTACTTCACCCAGGAACTAGACTAATACAAAAGCTACA
CACATCCACTTGCTGGCTGCAAGAAGTTCCTGGCAAACCTCAGCTGGAGCAAGCCACAAAACATCCACAGGTGACAAGCCCTCAGGCCAC
AAAAGAAACTGGCATGGAGATTAAAGAAGGCAAACAATCTTATAGACAAAAAATCATGGATGAACTAAAATATTATTACAATGGATTCTA
CTTACTTTGGATTGACGCCAAAGTTGCTGCCAGAATGGTTTGGAGGCTGTTGCATGGACAGGTCCTGACCAGACGAGAGAGACGAAGGGA
AGAAAAACAGAAAAAGAAAATGGCTGTAAAGTTGGAACTAGCAAAATTTCTTCAAGAAACCATGACAGAAATGGCAAGGAGGAACAGAGC
CAAGATGGGCGATGCCTCTACACAGCTCTCATCCTACGTGAAGCAGGTCCAGACAGGCCACAAGCCCAGCACAAAGGAGATAGTTCGCTT
CTCCAAACTATTTGAGGACCAGCTGGCCCTGGAACACTTAGATCGCCCTCAGCTGGTTGCCCTTTGCAAACTGCTGGAATTGCAGACATT
TGGAACCAACAACCTGCTCCGCTTTCAGCTCCTGATGAAACTGAAGTCTATAAAAGCAGATGATGAAATAATTGCCAAGGAAGGGGTGAC
AGCATTGAGTGTATCAGAACTACAGGCTGCCTGTAGGGCCCGAGGGATGAGATCACTGGGTCTCACGGAGGAACAACTGCGACAACAGCT
CACGGAGTGGCAGGACCTCCACCTGAAGGAGAACGTCCCTCCTTCCCTTTTGCTCCTGTCCCGCACCTTCTACCTGATAGATGTGAAGCC
CAAGCCGATTGAGATACCACTCAGTGGGGAGGGTCATGGAGTCCTGGAGATGCCCTCAGGCACCGGGAAGACAGTATCCCTGTTGGCCCT
GATCATGGCATACCAGAGAGCATATCCGCTGGAGGTGACCAAACTCATCTACTGCTCAAGAACTGTGCCAGAGATTGAGAAGGTGATTGA
AGAGCTTCGAAAGTTGCTCAACTTCTATGAGAAGCAGGAGGGCGAGAAGCTGCCGTTTCTGGGACTGGCTCTGAGCTCCCGCAAAAACTT
GTGTATTCACCCTGAGATCCTGCATGCCAATGTGGTGGTTTATAGCTACCACTACCTCCTGGACCCCAAGATTGCAGACCTGGTGTCCAA
GGAACTGGCCCGCAAGGCCGTCGTGGTCTTCGACGAGGCCCACAACATTGACAACGTCTGCATCGACTCCATGAGCGTCAACCTCACCCG
CCGGACCCTTGACCGGTGCCAGGGCAACCTGGAGACCCTGCAGAAGACGGTGCTCAGGATCAAAGAGACAGACGAGCAGCGCCTGCGGGA
CGAGTACCGGCGTCTGGTGGAGGGGCTGCGGGAGGCCAGCGCCGCCCGGGAGACGGACGCCCACCTGGCCAACCCCGTGCTGCCCGACGA
AGTGCTGCAGGAGGCAGTGCCTGGCTCCATCCGCACGGCCGAGCATTTCCTGGGCTTCCTGAGGCGGCTGCTGGAGTACGTGAAGTGGCG
GCTGCGTGTGCAGCATGTGGTGCAGGAGAGCCCGCCCGCCTTCCTGAGCGGCCTGGCCCAGCGCGTGTGCATCCAGCGCAAGCCCCTCAG
ATTCTGTGCTGAACGCCTCCGGTCCCTGCTGCATACTCTGGAGATCACCGACCTTGCTGACTTCTCCCCGCTCACCCTCCTTGCTAACTT
TGCCACCCTTGTCAGCACCTACGCCAAAGGCTTCACCATCATCATCGAGCCCTTTGACGACAGAACCCCGACCATTGCCAACCCCATCCT
GCACTTCAGCTGCATGGACGCCTCGCTGGCCATCAAACCCGTATTTGAGCGTTTCCAGTCTGTCATCATCACATCTGGGACACTGTCCCC
GCTGGACATCTACCCCAAGATCCTGGACTTCCACCCCGTCACCATGGCAACCTTCACCATGACGCTGGCACGGGTCTGCCTCTGCCCTAT
GATCATCGGCCGTGGCAATGACCAGGTGGCCATCAGCTCCAAATTTGAGACCCGGGAGGATATTGCTGTGATCCGGAACTATGGGAACCT
CCTGCTGGAGATGTCCGCTGTGGTCCCTGATGGCATCGTGGCCTTCTTCACCAGCTACCAGTACATGGAGAGCACCGTGGCCTCCTGGTA
TGAGCAGGGGATCCTTGAGAACATCCAGAGGAACAAGCTGCTCTTTATTGAGACCCAGGATGGTGCCGAAACCAGTGTCGCCCTGGAGAA
GTACCAGGAGGCCTGCGAGAATGGCCGCGGGGCCATCCTGCTGTCAGTGGCCCGGGGCAAAGTGTCCGAGGGAATCGACTTTGTGCACCA
CTACGGGCGGGCCGTCATCATGTTTGGCGTCCCCTACGTCTACACACAGAGCCGCATTCTCAAGGCGCGGCTGGAATACCTGCGGGACCA
GTTCCAGATTCGTGAGAATGACTTTCTTACCTTCGATGCCATGCGCCACGCGGCCCAGTGTGTGGGTCGGGCCATCAGGGGCAAGACGGA
CTACGGCCTCATGGTCTTTGCCGACAAGCGGTTTGCCCGTGGGGACAAGCGGGGGAAGCTGCCCCGCTGGATCCAGGAGCACCTCACAGA
TGCCAACCTCAACCTGACCGTGGACGAGGGTGTCCAGGTGGCCAAGTACTTCCTGCGGCAGATGGCACAGCCCTTCCACCGGGAGGATCA
GCTGGGCCTGTCCCTGCTCAGCCTGGAGCAGCTAGAATCAGAGGAGACGCTGAAGAGGATAGAGCAGATTGCTCAGCAGCTCTGAGTGGG

>44492_44492_18_LETM2-ERCC2_LETM2_chr8_38262024_ENST00000524874_ERCC2_chr19_45872405_ENST00000391944_length(amino acids)=1005AA_BP=358
MAFYSYNSVLAIARTRFPSHFVHPTCSSYSPSCAFLHLPDSHLNKTCMKNYESKKYSDPSQPGNTVLHPGTRLIQKLHTSTCWLQEVPGK
PQLEQATKHPQVTSPQATKETGMEIKEGKQSYRQKIMDELKYYYNGFYLLWIDAKVAARMVWRLLHGQVLTRRERRREEKQKKKMAVKLE
LAKFLQETMTEMARRNRAKMGDASTQLSSYVKQVQTGHKPSTKEIVRFSKLFEDQLALEHLDRPQLVALCKLLELQTFGTNNLLRFQLLM
KLKSIKADDEIIAKEGVTALSVSELQAACRARGMRSLGLTEEQLRQQLTEWQDLHLKENVPPSLLLLSRTFYLIDVKPKPIEIPLSGEGH
GVLEMPSGTGKTVSLLALIMAYQRAYPLEVTKLIYCSRTVPEIEKVIEELRKLLNFYEKQEGEKLPFLGLALSSRKNLCIHPEILHANVV
VYSYHYLLDPKIADLVSKELARKAVVVFDEAHNIDNVCIDSMSVNLTRRTLDRCQGNLETLQKTVLRIKETDEQRLRDEYRRLVEGLREA
SAARETDAHLANPVLPDEVLQEAVPGSIRTAEHFLGFLRRLLEYVKWRLRVQHVVQESPPAFLSGLAQRVCIQRKPLRFCAERLRSLLHT
LEITDLADFSPLTLLANFATLVSTYAKGFTIIIEPFDDRTPTIANPILHFSCMDASLAIKPVFERFQSVIITSGTLSPLDIYPKILDFHP
VTMATFTMTLARVCLCPMIIGRGNDQVAISSKFETREDIAVIRNYGNLLLEMSAVVPDGIVAFFTSYQYMESTVASWYEQGILENIQRNK
LLFIETQDGAETSVALEKYQEACENGRGAILLSVARGKVSEGIDFVHHYGRAVIMFGVPYVYTQSRILKARLEYLRDQFQIRENDFLTFD
AMRHAAQCVGRAIRGKTDYGLMVFADKRFARGDKRGKLPRWIQEHLTDANLNLTVDEGVQVAKYFLRQMAQPFHREDQLGLSLLSLEQLE

--------------------------------------------------------------
>44492_44492_19_LETM2-ERCC2_LETM2_chr8_38262024_ENST00000524874_ERCC2_chr19_45872405_ENST00000391945_length(transcript)=5171nt_BP=1201nt
GTAGAGACTTGGCTTCGGGCCCTTCTAGCTTGGGGGTCCCGGGAAGGAGCTGGGAGGACCTAGGCGGCCGTTCCGCGGAGCCCGGCCGAG
GAGGTCCCTATGTTAACTACTTGAGACAAAAATAAATATGGCCTTCTACAGTTATAATTCAGTTCTGGCTATTGCTCGAACAAGATTCCC
TAGCCATTTTGTCCATCCTACCTGCTCTTCTTATTCCCCATCATGTGCATTTCTTCACTTGCCAGATTCCCATTTAAATAAGACATGTAT
GAAGAACTATGAGAGCAAGAAGTACTCGGATCCTAGTCAGCCAGGCAATACAGTACTTCACCCAGGAACTAGACTAATACAAAAGCTACA
CACATCCACTTGCTGGCTGCAAGAAGTTCCTGGCAAACCTCAGCTGGAGCAAGCCACAAAACATCCACAGGTGACAAGCCCTCAGGCCAC
AAAAGAAACTGGCATGGAGATTAAAGAAGGCAAACAATCTTATAGACAAAAAATCATGGATGAACTAAAATATTATTACAATGGATTCTA
CTTACTTTGGATTGACGCCAAAGTTGCTGCCAGAATGGTTTGGAGGCTGTTGCATGGACAGGTCCTGACCAGACGAGAGAGACGAAGGGA
AGAAAAACAGAAAAAGAAAATGGCTGTAAAGTTGGAACTAGCAAAATTTCTTCAAGAAACCATGACAGAAATGGCAAGGAGGAACAGAGC
CAAGATGGGCGATGCCTCTACACAGCTCTCATCCTACGTGAAGCAGGTCCAGACAGGCCACAAGCCCAGCACAAAGGAGATAGTTCGCTT
CTCCAAACTATTTGAGGACCAGCTGGCCCTGGAACACTTAGATCGCCCTCAGCTGGTTGCCCTTTGCAAACTGCTGGAATTGCAGACATT
TGGAACCAACAACCTGCTCCGCTTTCAGCTCCTGATGAAACTGAAGTCTATAAAAGCAGATGATGAAATAATTGCCAAGGAAGGGGTGAC
AGCATTGAGTGTATCAGAACTACAGGCTGCCTGTAGGGCCCGAGGGATGAGATCACTGGGTCTCACGGAGGAACAACTGCGACAACAGCT
CACGGAGTGGCAGGACCTCCACCTGAAGGAGAACGTCCCTCCTTCCCTTTTGCTCCTGTCCCGCACCTTCTACCTGATAGATGTGAAGCC
CAAGCCGATTGAGATACCACTCAGTGGGGAGGGTCATGGAGTCCTGGAGATGCCCTCAGGCACCGGGAAGACAGTATCCCTGTTGGCCCT
GATCATGGCATACCAGAGAGCATATCCGCTGGAGGTGACCAAACTCATCTACTGCTCAAGAACTGTGCCAGAGATTGAGAAGGTGATTGA
AGAGCTTCGAAAGTTGCTCAACTTCTATGAGAAGCAGGAGGGCGAGAAGCTGCCGTTTCTGGGACTGGCTCTGAGCTCCCGCAAAAACTT
GTGTATTCACCCTGAGGTGACACCCCTGCGCTTTGGGAAGGACGTCGATGGGAAATGCCACAGCCTCACAGCCTCCTATGTGCGGGCGCA
GTACCAGCATGACACCAGCCTGCCCCACTGCCGATTCTATGAGGAATTTGATGCCCATGGGCGTGAGGTGCCCCTCCCCGCTGGCATCTA
CAACCTGGATGACCTGAAGGCCCTGGGGCGGCGCCAGGGCTGGTGCCCATACTTCCTTGCTCGATACTCAATCCTGCATGCCAATGTGGT
GGTTTATAGCTACCACTACCTCCTGGACCCCAAGATTGCAGACCTGGTGTCCAAGGAACTGGCCCGCAAGGCCGTCGTGGTCTTCGACGA
GGCCCACAACATTGACAACGTCTGCATCGACTCCATGAGCGTCAACCTCACCCGCCGGACCCTTGACCGGTGCCAGGGCAACCTGGAGAC
CCTGCAGAAGACGGTGCTCAGGATCAAAGAGACAGACGAGCAGCGCCTGCGGGACGAGTACCGGCGTCTGGTGGAGGGGCTGCGGGAGGC
CAGCGCCGCCCGGGAGACGGACGCCCACCTGGCCAACCCCGTGCTGCCCGACGAAGTGCTGCAGGAGGCAGTGCCTGGCTCCATCCGCAC
GGCCGAGCATTTCCTGGGCTTCCTGAGGCGGCTGCTGGAGTACGTGAAGTGGCGGCTGCGTGTGCAGCATGTGGTGCAGGAGAGCCCGCC
CGCCTTCCTGAGCGGCCTGGCCCAGCGCGTGTGCATCCAGCGCAAGCCCCTCAGATTCTGTGCTGAACGCCTCCGGTCCCTGCTGCATAC
TCTGGAGATCACCGACCTTGCTGACTTCTCCCCGCTCACCCTCCTTGCTAACTTTGCCACCCTTGTCAGCACCTACGCCAAAGGCTTCAC
CATCATCATCGAGCCCTTTGACGACAGAACCCCGACCATTGCCAACCCCATCCTGCACTTCAGCTGCATGGACGCCTCGCTGGCCATCAA
ACCCGTATTTGAGCGTTTCCAGTCTGTCATCATCACATCTGGGACACTGTCCCCGCTGGACATCTACCCCAAGATCCTGGACTTCCACCC
CGTCACCATGGCAACCTTCACCATGACGCTGGCACGGGTCTGCCTCTGCCCTATGATCATCGGCCGTGGCAATGACCAGGTGGCCATCAG
CTCCAAATTTGAGACCCGGGAGGATATTGCTGTGATCCGGAACTATGGGAACCTCCTGCTGGAGATGTCCGCTGTGGTCCCTGATGGCAT
CGTGGCCTTCTTCACCAGCTACCAGTACATGGAGAGCACCGTGGCCTCCTGGTATGAGCAGGGGATCCTTGAGAACATCCAGAGGAACAA
GCTGCTCTTTATTGAGACCCAGGATGGTGCCGAAACCAGTGTCGCCCTGGAGAAGTACCAGGAGGCCTGCGAGAATGGCCGCGGGGCCAT
CCTGCTGTCAGTGGCCCGGGGCAAAGTGTCCGAGGGAATCGACTTTGTGCACCACTACGGGCGGGCCGTCATCATGTTTGGCGTCCCCTA
CGTCTACACACAGAGCCGCATTCTCAAGGCGCGGCTGGAATACCTGCGGGACCAGTTCCAGATTCGTGAGAATGACTTTCTTACCTTCGA
TGCCATGCGCCACGCGGCCCAGTGTGTGGGTCGGGCCATCAGGGGCAAGACGGACTACGGCCTCATGGTCTTTGCCGACAAGCGGTTTGC
CCGTGGGGACAAGCGGGGGAAGCTGCCCCGCTGGATCCAGGAGCACCTCACAGATGCCAACCTCAACCTGACCGTGGACGAGGGTGTCCA
GGTGGCCAAGTACTTCCTGCGGCAGATGGCACAGCCCTTCCACCGGGAGGATCAGCTGGGCCTGTCCCTGCTCAGCCTGGAGCAGCTAGA
ATCAGAGGAGACGCTGAAGAGGATAGAGCAGATTGCTCAGCAGCTCTGAGTGGGGCGGGTGGGGCCATAAACGGTTCCTGGTGACTCCTG
AGTCTTGCCTGGCCCTGGTTCCCAGCGGCGGTGGTGCTAGAAGGTCTTATGAAGTCAGGTGACATTTCTCACTGTCACGTCCACAGCCTT
TAATCGCAGGAGAAGGCAGCTATCCACCAGGTACCCAGAGGCAAGGGGGGGCCAGGAGATGATAGACCCCCTCTCACCCCACCAGCCCAT
CCCTCCTGCACTGTTCCCAAGAAGCTGCGGCCAGCGCAGTTCACTGGACGTTAGTGGGGGCTCAGGTCCTGGGTGCTGGCGCTGAGGGTC
CGAGGGGCCTTGTCCAGGTGCCAGCTGGGAAACTGGAGACAGGCACAGGGGATGGTTGGAGGGGAGGTGAGGGGCAAGTGTTACATCCAC
CCTCCAGCTCCAGGTCCAGCCTGGCAGCCAACTATCCAACCCCCTCGCCTCTACCCCAAGTAAAACCCATCTTTGCTCCTGTCCTGGGTC
TCTTCTGACACCAACCCACCACCTGCTGACTCCACCACTGGCCCGACCGCCCTGCCTTTGCCTCATCTCTGCACCTACCCACATGGCCTC
CTCTATTTTTGACCCAGATGTCCCCCTCACCTGAGTCCCAGGAGCCCTTGGAGCATCCACGTTCAGTGTGTTGAGTGACATGGCTCTCTT
CATTCTGCAAAGAGGGCAGCAGGGAGGAAATGAGTGAATCCAGGAGTGGCCCCCCTCCACGAGGGACCTTTCCAGCACAGGGTTTGATCT
GTGTGTATCACAGGGGAGATGGGAGCCATGGAAGGTTCTTGAGCAAGATGGGGGTGGGGGTGGGGTGGGCTGTGGATTCTGCTGATGTCA
GGGCTCTTTGCCGACCTGATCAACACTCACCCGGCTGCTCCTGCCGCCGCCTCGCCTCGGAGCCGGGAGACCAGCTTCTCACTTCCTCGC
CTGATAGACTCACGGATCTTGGAGAGTGAGCTGCTGCGGCGAAGGGCCTGGGGAGGGGCCGGGGATGCTGCTCAGTCCCCCAGGCCCATG
CAGTCCCCACGCCCACCCCAGGAGCCGAAGCACAGCCCATCCTCACCTGTTCTGCGTCACCAGCTGTGCCTGTGTTGGGGGCACCTAGGG
GGAAAGATGGGGGACACTGAGATGGGGACATAGAGAAGCCACCAGGAGGGAAGACAGACAGGGGCTAGGGGCTCACCGAGAGGGGCGGGT
AGGTCCTCCTTGTGGAGGATTTCTTTGTACAGCTCTTCCGCTTGTTGATACTTGTTCTGTTTCAGGTAGGCTGAGGCCTGCGGAGAAGGG
AGTGTCTGGGAACTTTTCGGACCCCAGTTCCCAACACTGCATCCAGTCCCGCCTTTTTTTTTTTTTTTGTAGAGACAGGGGTCTTGGTAT
GTTGCCCAGGCTGGTCTTGAACTCCTAGCCTCAAGTGATCCTCCTGCCTTGGCCTCCCAAAGTGTTGGGGTTACAAGCGTGAACCACCAC
GTCTGGCCCCACTTTCTAATGTGCTGACCTGGCCGTATCCTTCCCCTGCCTAAAGCCTTGCCCTGGGGCAGAGTGGGTTTGGAGCTCGGC
CTTACTTCCTGCCCTGGGGATGGAGGACAGGCAGCCTCCTGTTTCTGAGCCTGTCTGCTGTACTTTGGGCTGGTGGCATGGCCTCGGTGC
CTCAGTCTTCCCACACGCAAAGTGGAGCGACAGCTCCCACCTCATAGGGACGCTATAAGAACTAGCGATGTGGGGACCGGGCTAAGAGGG

>44492_44492_19_LETM2-ERCC2_LETM2_chr8_38262024_ENST00000524874_ERCC2_chr19_45872405_ENST00000391945_length(amino acids)=1083AA_BP=358
MAFYSYNSVLAIARTRFPSHFVHPTCSSYSPSCAFLHLPDSHLNKTCMKNYESKKYSDPSQPGNTVLHPGTRLIQKLHTSTCWLQEVPGK
PQLEQATKHPQVTSPQATKETGMEIKEGKQSYRQKIMDELKYYYNGFYLLWIDAKVAARMVWRLLHGQVLTRRERRREEKQKKKMAVKLE
LAKFLQETMTEMARRNRAKMGDASTQLSSYVKQVQTGHKPSTKEIVRFSKLFEDQLALEHLDRPQLVALCKLLELQTFGTNNLLRFQLLM
KLKSIKADDEIIAKEGVTALSVSELQAACRARGMRSLGLTEEQLRQQLTEWQDLHLKENVPPSLLLLSRTFYLIDVKPKPIEIPLSGEGH
GVLEMPSGTGKTVSLLALIMAYQRAYPLEVTKLIYCSRTVPEIEKVIEELRKLLNFYEKQEGEKLPFLGLALSSRKNLCIHPEVTPLRFG
KDVDGKCHSLTASYVRAQYQHDTSLPHCRFYEEFDAHGREVPLPAGIYNLDDLKALGRRQGWCPYFLARYSILHANVVVYSYHYLLDPKI
ADLVSKELARKAVVVFDEAHNIDNVCIDSMSVNLTRRTLDRCQGNLETLQKTVLRIKETDEQRLRDEYRRLVEGLREASAARETDAHLAN
PVLPDEVLQEAVPGSIRTAEHFLGFLRRLLEYVKWRLRVQHVVQESPPAFLSGLAQRVCIQRKPLRFCAERLRSLLHTLEITDLADFSPL
TLLANFATLVSTYAKGFTIIIEPFDDRTPTIANPILHFSCMDASLAIKPVFERFQSVIITSGTLSPLDIYPKILDFHPVTMATFTMTLAR
VCLCPMIIGRGNDQVAISSKFETREDIAVIRNYGNLLLEMSAVVPDGIVAFFTSYQYMESTVASWYEQGILENIQRNKLLFIETQDGAET
SVALEKYQEACENGRGAILLSVARGKVSEGIDFVHHYGRAVIMFGVPYVYTQSRILKARLEYLRDQFQIRENDFLTFDAMRHAAQCVGRA
IRGKTDYGLMVFADKRFARGDKRGKLPRWIQEHLTDANLNLTVDEGVQVAKYFLRQMAQPFHREDQLGLSLLSLEQLESEETLKRIEQIA

--------------------------------------------------------------
>44492_44492_20_LETM2-ERCC2_LETM2_chr8_38262024_ENST00000524874_ERCC2_chr19_45872405_ENST00000485403_length(transcript)=2487nt_BP=1201nt
GTAGAGACTTGGCTTCGGGCCCTTCTAGCTTGGGGGTCCCGGGAAGGAGCTGGGAGGACCTAGGCGGCCGTTCCGCGGAGCCCGGCCGAG
GAGGTCCCTATGTTAACTACTTGAGACAAAAATAAATATGGCCTTCTACAGTTATAATTCAGTTCTGGCTATTGCTCGAACAAGATTCCC
TAGCCATTTTGTCCATCCTACCTGCTCTTCTTATTCCCCATCATGTGCATTTCTTCACTTGCCAGATTCCCATTTAAATAAGACATGTAT
GAAGAACTATGAGAGCAAGAAGTACTCGGATCCTAGTCAGCCAGGCAATACAGTACTTCACCCAGGAACTAGACTAATACAAAAGCTACA
CACATCCACTTGCTGGCTGCAAGAAGTTCCTGGCAAACCTCAGCTGGAGCAAGCCACAAAACATCCACAGGTGACAAGCCCTCAGGCCAC
AAAAGAAACTGGCATGGAGATTAAAGAAGGCAAACAATCTTATAGACAAAAAATCATGGATGAACTAAAATATTATTACAATGGATTCTA
CTTACTTTGGATTGACGCCAAAGTTGCTGCCAGAATGGTTTGGAGGCTGTTGCATGGACAGGTCCTGACCAGACGAGAGAGACGAAGGGA
AGAAAAACAGAAAAAGAAAATGGCTGTAAAGTTGGAACTAGCAAAATTTCTTCAAGAAACCATGACAGAAATGGCAAGGAGGAACAGAGC
CAAGATGGGCGATGCCTCTACACAGCTCTCATCCTACGTGAAGCAGGTCCAGACAGGCCACAAGCCCAGCACAAAGGAGATAGTTCGCTT
CTCCAAACTATTTGAGGACCAGCTGGCCCTGGAACACTTAGATCGCCCTCAGCTGGTTGCCCTTTGCAAACTGCTGGAATTGCAGACATT
TGGAACCAACAACCTGCTCCGCTTTCAGCTCCTGATGAAACTGAAGTCTATAAAAGCAGATGATGAAATAATTGCCAAGGAAGGGGTGAC
AGCATTGAGTGTATCAGAACTACAGGCTGCCTGTAGGGCCCGAGGGATGAGATCACTGGGTCTCACGGAGGAACAACTGCGACAACAGCT
CACGGAGTGGCAGGACCTCCACCTGAAGGAGAACGTCCCTCCTTCCCTTTTGCTCCTGTCCCGCACCTTCTACCTGATAGATGTGAAGCC
CAAGCCGATTGAGATACCACTCAGTGGGGAGGGTCATGGAGTCCTGGAGATGCCCTCAGGCACCGGGAAGACAGTATCCCTGTTGGCCCT
GATCATGGCATACCAGAGAGCATATCCGCTGGAGGTGACCAAACTCATCTACTGCTCAAGAACTGTGCCAGAGATTGAGAAGGTGATTGA
AGAGCTTCGAAAGTTGCTCAACTTCTATGAGAAGCAGGAGGGCGAGAAGCTGCCGTTTCTGGGACTGGCTCTGAGCTCCCGCAAAAACTT
GTGTATTCACCCTGAGGTGACACCCCTGCGCTTTGGGAAGGACGTCGATGGGAAATGCCACAGCCTCACAGCCTCCTATGTGCGGGCGCA
GTACCAGCATGACACCAGCCTGCCCCACTGCCGATTCTATGAGGAATTTGATGCCCATGGGCGTGAGGTGCCCCTCCCCGCTGGCATCTA
CAACCTGGATGACCTGAAGGCCCTGGGGCGGCGCCAGGGCTGGTGCCCATACTTCCTTGCTCGATACTCAATCCTGCATGCCAATGTGGT
GGTTTATAGCTACCACTACCTCCTGGACCCCAAGATTGCAGACCTGGTGTCCAAGGAACTGGCCCGCAAGGCCGTCGTGGTCTTCGACGA
GGCCCACAACATTGACAACGTCTGCATCGACTCCATGAGCGTCAACCTCACCCGCCGGACCCTTGACCGGTGCCAGGGCAACCTGGAGAC
CCTGCAGAAGACGGTGCTCAGGATCAAAGAGACAGACGAGCAGCGCCTGCGGGACGAGTACCGGCGTCTGGTGGAGGGGCTGCGGGAGGC
CAGCGCCGCCCGGGAGACGGACGCCCACCTGGCCAACCCCGTGCTGCCCGACGAAGTGCTGCAGGAGGCAGTGCCTGGCTCCATCCGCAC
GGCCGAGCATTTCCTGGGCTTCCTGAGGCGGCTGCTGGAGTACGTGAAGTGGCGGCTGCGTGTGCAGCATGTGGTGCAGGAGAGCCCGCC
CGCCTTCCTGAGCGGCCTGGCCCAGCGCGTGTGCATCCAGCGCAAGCCCCTCAGATTCTGTGCTGAACGCCTCCGGTCCCTGCTGCATAC
TCTGGAGATCACCGACCTTGCTGACTTCTCCCCGCTCACCCTCCTTGCTAACTTTGCCACCCTTGTCAGCACCTACGCCAAAGGCCAGGC
TCAGCACTGTGGAAGCAGCAGGAACCAAAAAAGATCTCATCCCTAACCCCCCAGAACTTATATTCCAGATGGGAAAACCAGTAGCAAAGA

>44492_44492_20_LETM2-ERCC2_LETM2_chr8_38262024_ENST00000524874_ERCC2_chr19_45872405_ENST00000485403_length(amino acids)=752AA_BP=358
MAFYSYNSVLAIARTRFPSHFVHPTCSSYSPSCAFLHLPDSHLNKTCMKNYESKKYSDPSQPGNTVLHPGTRLIQKLHTSTCWLQEVPGK
PQLEQATKHPQVTSPQATKETGMEIKEGKQSYRQKIMDELKYYYNGFYLLWIDAKVAARMVWRLLHGQVLTRRERRREEKQKKKMAVKLE
LAKFLQETMTEMARRNRAKMGDASTQLSSYVKQVQTGHKPSTKEIVRFSKLFEDQLALEHLDRPQLVALCKLLELQTFGTNNLLRFQLLM
KLKSIKADDEIIAKEGVTALSVSELQAACRARGMRSLGLTEEQLRQQLTEWQDLHLKENVPPSLLLLSRTFYLIDVKPKPIEIPLSGEGH
GVLEMPSGTGKTVSLLALIMAYQRAYPLEVTKLIYCSRTVPEIEKVIEELRKLLNFYEKQEGEKLPFLGLALSSRKNLCIHPEVTPLRFG
KDVDGKCHSLTASYVRAQYQHDTSLPHCRFYEEFDAHGREVPLPAGIYNLDDLKALGRRQGWCPYFLARYSILHANVVVYSYHYLLDPKI
ADLVSKELARKAVVVFDEAHNIDNVCIDSMSVNLTRRTLDRCQGNLETLQKTVLRIKETDEQRLRDEYRRLVEGLREASAARETDAHLAN
PVLPDEVLQEAVPGSIRTAEHFLGFLRRLLEYVKWRLRVQHVVQESPPAFLSGLAQRVCIQRKPLRFCAERLRSLLHTLEITDLADFSPL

--------------------------------------------------------------
>44492_44492_21_LETM2-ERCC2_LETM2_chr8_38262024_ENST00000527710_ERCC2_chr19_45872405_ENST00000221481_length(transcript)=1356nt_BP=733nt
AGTAGGTATGATTTAGTCAGCCCAACAGACAGTTCAGCAGCCCCTGAGAAGAGGGAGCCTTCACTGAGTGTGGCAGTCACTGTGCCGGTG
AGAAAACAGAGGCAGCTCCTTCCTTCTCCCCGTTCTGTGCCACTCTACTAGACAGCGTTGACAGCATATGGAAGAAAAACAGAAAAAGAA
AATGGCTGTAAAGTTGGAACTAGCAAAATTTCTTCAAGAAACCATGACAGAAATGGCAAGGAGGAACAGAGCCAAGATGGGCGATGCCTC
TACACAGCTCTCATCCTACGTGAAGCAGGTCCAGACAGGCCACAAGCCCAGCACAAAGGAGATAGTTCGCTTCTCCAAACTATTTGAGGA
CCAGCTGGCCCTGGAACACTTAGATCGCCCTCAGCTGGTTGCCCTTTGCAAACTGCTGGAATTGCAGACATTTGGAACCAACAACCTGCT
CCGCTTTCAGCTCCTGATGAAACTGAAGTCTATAAAAGCAGATGATGAAATAATTGCCAAGGAAGGGGTGACAGCATTGAGTGTATCAGA
ACTACAGGCTGCCTGTAGGGCCCGAGGGATGAGATCACTGGGTCTCACGGAGGAACAACTGCGACAACAGCTCACGGAGTGGCAGGACCT
CCACCTGAAGGAGAACGTCCCTCCTTCCCTTTTGCTCCTGTCCCGCACCTTCTACCTGATAGATGTGAAGCCCAAGCCGATTGAGATACC
ACTCAGTGGGGAGGGTCATGGAGTCCTGGAGATGCCCTCAGGCACCGGGAAGACAGTATCCCTGTTGGCCCTGATCATGGCATACCAGAG
AGCATATCCGCTGGAGGTGACCAAACTCATCTACTGCTCAAGAACTGTGCCAGAGATTGAGAAGGTGATTGAAGAGCTTCGAAAGTTGCT
CAACTTCTATGAGAAGCAGGAGGGCGAGAAGCTGCCGTTTCTGGGACTGGCTCTGAGCTCCCGCAAAAACTTGTGTATTCACCCTGAGAC
AACGTCTGCATCGACTCCATGAGCGTCAACCTCACCCGCCGGACCCTTGACCGGTGCCAGGGCAACCTGGAGACCCTGCAGAAGACGGTG
CTCAGGATCAAAGAGACAGACGAGCAGCGCCTGCGGGACGAGTACCGGCGTCTGGTGGAGGGGCTGCGGGAGGCCAGCGCCGCCCGGGAG
ACGGACGCCCACCTGGCCAACCCCGTGCTGCCCGACGAAGTGCTGCAGGAGGCAGTGCCTGGCTCCATCCGCACGGCCGAGCATTTCCTG
GGCTTCCTGAGGCGGCTGCTGGAGTACGTGAAGTGGCGGCTGCGTGTGCAGCATGTGGTGCAGGAGAGCCCGCCCGCCTTCCTGAGCGGC

>44492_44492_21_LETM2-ERCC2_LETM2_chr8_38262024_ENST00000527710_ERCC2_chr19_45872405_ENST00000221481_length(amino acids)=284AA_BP=192
MEEKQKKKMAVKLELAKFLQETMTEMARRNRAKMGDASTQLSSYVKQVQTGHKPSTKEIVRFSKLFEDQLALEHLDRPQLVALCKLLELQ
TFGTNNLLRFQLLMKLKSIKADDEIIAKEGVTALSVSELQAACRARGMRSLGLTEEQLRQQLTEWQDLHLKENVPPSLLLLSRTFYLIDV
KPKPIEIPLSGEGHGVLEMPSGTGKTVSLLALIMAYQRAYPLEVTKLIYCSRTVPEIEKVIEELRKLLNFYEKQEGEKLPFLGLALSSRK

--------------------------------------------------------------
>44492_44492_22_LETM2-ERCC2_LETM2_chr8_38262024_ENST00000527710_ERCC2_chr19_45872405_ENST00000391940_length(transcript)=1918nt_BP=733nt
AGTAGGTATGATTTAGTCAGCCCAACAGACAGTTCAGCAGCCCCTGAGAAGAGGGAGCCTTCACTGAGTGTGGCAGTCACTGTGCCGGTG
AGAAAACAGAGGCAGCTCCTTCCTTCTCCCCGTTCTGTGCCACTCTACTAGACAGCGTTGACAGCATATGGAAGAAAAACAGAAAAAGAA
AATGGCTGTAAAGTTGGAACTAGCAAAATTTCTTCAAGAAACCATGACAGAAATGGCAAGGAGGAACAGAGCCAAGATGGGCGATGCCTC
TACACAGCTCTCATCCTACGTGAAGCAGGTCCAGACAGGCCACAAGCCCAGCACAAAGGAGATAGTTCGCTTCTCCAAACTATTTGAGGA
CCAGCTGGCCCTGGAACACTTAGATCGCCCTCAGCTGGTTGCCCTTTGCAAACTGCTGGAATTGCAGACATTTGGAACCAACAACCTGCT
CCGCTTTCAGCTCCTGATGAAACTGAAGTCTATAAAAGCAGATGATGAAATAATTGCCAAGGAAGGGGTGACAGCATTGAGTGTATCAGA
ACTACAGGCTGCCTGTAGGGCCCGAGGGATGAGATCACTGGGTCTCACGGAGGAACAACTGCGACAACAGCTCACGGAGTGGCAGGACCT
CCACCTGAAGGAGAACGTCCCTCCTTCCCTTTTGCTCCTGTCCCGCACCTTCTACCTGATAGATGTGAAGCCCAAGCCGATTGAGATACC
ACTCAGTGGGGAGGGTCATGGAGTCCTGGAGATGCCCTCAGGCACCGGGAAGACAGTATCCCTGTTGGCCCTGATCATGGCATACCAGAG
AGCATATCCGCTGGAGGTGACCAAACTCATCTACTGCTCAAGAACTGTGCCAGAGATTGAGAAGGTGATTGAAGAGCTTCGAAAGTTGCT
CAACTTCTATGAGAAGCAGGAGGGCGAGAAGCTGCCGTTTCTGGGACTGGCTCTGAGCTCCCGCAAAAACTTGTGTATTCACCCTGAGGT
GACACCCCTGCGCTTTGGGAAGGACGTCGATGGGAAATGCCACAGCCTCACAGCCTCCTATGTGCGGGCGCAGTACCAGCATGACACCAG
CCTGCCCCACTGCCGATTCTATGAGGAATTTGATGCCCATGGGCGTGAGGTGCCCCTCCCCGCTGGCATCTACAACCTGGATGACCTGAA
GGCCCTGGGGCGGCGCCAGGGCTGGTGCCCATACTTCCTTGCTCGATACTCAATCCTGCATGCCAATGTGGTGGTTTATAGCTACCACTA
CCTCCTGGACCCCAAGATTGCAGACCTGGTGTCCAAGGAACTGGCCCGCAAGGCCGTCGTGGTCTTCGACGAGGCCCACAACATTGACAA
CGTCTGCATCGACTCCATGAGCGTCAACCTCACCCGCCGGACCCTTGACCGGTGCCAGGGCAACCTGGAGACCCTGCAGAAGACGGTGCT
CAGGATCAAAGAGACAGACGAGCAGCGCCTGCGGGACGAGTACCGGCGTCTGGTGGAGGGGCTGCGGGAGGCCAGCGCCGCCCGGGAGAC
GGACGCCCACCTGGCCAACCCCGTGCTGCCCGACGAAGTGCTGCAGGAGGCAGTGCCTGGCTCCATCCGCACGGCCGAGCATTTCCTGGG
CTTCCTGAGGCGGCTGCTGGAGTACGTGAAGTGGCGGCTGCGTGTGCAGCATGTGGTGCAGGAGAGCCCGCCCGCCTTCCTGAGCGGCCT
GGCCCAGCGCGTGTGCATCCAGCGCAAGCCCCTCAGATTCTGTGCTGAACGCCTCCGGTCCCTGCTGCATACTCTGGAGATCACCGACCT
TGCTGACTTCTCCCCGCTCACCCTCCTTGCTAACTTTGCCACCCTTGTCAGCACCTACGCCAAAGGCCAGGCTCAGCACTGTGGAAGCAG

>44492_44492_22_LETM2-ERCC2_LETM2_chr8_38262024_ENST00000527710_ERCC2_chr19_45872405_ENST00000391940_length(amino acids)=587AA_BP=192
MEEKQKKKMAVKLELAKFLQETMTEMARRNRAKMGDASTQLSSYVKQVQTGHKPSTKEIVRFSKLFEDQLALEHLDRPQLVALCKLLELQ
TFGTNNLLRFQLLMKLKSIKADDEIIAKEGVTALSVSELQAACRARGMRSLGLTEEQLRQQLTEWQDLHLKENVPPSLLLLSRTFYLIDV
KPKPIEIPLSGEGHGVLEMPSGTGKTVSLLALIMAYQRAYPLEVTKLIYCSRTVPEIEKVIEELRKLLNFYEKQEGEKLPFLGLALSSRK
NLCIHPEVTPLRFGKDVDGKCHSLTASYVRAQYQHDTSLPHCRFYEEFDAHGREVPLPAGIYNLDDLKALGRRQGWCPYFLARYSILHAN
VVVYSYHYLLDPKIADLVSKELARKAVVVFDEAHNIDNVCIDSMSVNLTRRTLDRCQGNLETLQKTVLRIKETDEQRLRDEYRRLVEGLR
EASAARETDAHLANPVLPDEVLQEAVPGSIRTAEHFLGFLRRLLEYVKWRLRVQHVVQESPPAFLSGLAQRVCIQRKPLRFCAERLRSLL

--------------------------------------------------------------
>44492_44492_23_LETM2-ERCC2_LETM2_chr8_38262024_ENST00000527710_ERCC2_chr19_45872405_ENST00000391944_length(transcript)=2703nt_BP=733nt
AGTAGGTATGATTTAGTCAGCCCAACAGACAGTTCAGCAGCCCCTGAGAAGAGGGAGCCTTCACTGAGTGTGGCAGTCACTGTGCCGGTG
AGAAAACAGAGGCAGCTCCTTCCTTCTCCCCGTTCTGTGCCACTCTACTAGACAGCGTTGACAGCATATGGAAGAAAAACAGAAAAAGAA
AATGGCTGTAAAGTTGGAACTAGCAAAATTTCTTCAAGAAACCATGACAGAAATGGCAAGGAGGAACAGAGCCAAGATGGGCGATGCCTC
TACACAGCTCTCATCCTACGTGAAGCAGGTCCAGACAGGCCACAAGCCCAGCACAAAGGAGATAGTTCGCTTCTCCAAACTATTTGAGGA
CCAGCTGGCCCTGGAACACTTAGATCGCCCTCAGCTGGTTGCCCTTTGCAAACTGCTGGAATTGCAGACATTTGGAACCAACAACCTGCT
CCGCTTTCAGCTCCTGATGAAACTGAAGTCTATAAAAGCAGATGATGAAATAATTGCCAAGGAAGGGGTGACAGCATTGAGTGTATCAGA
ACTACAGGCTGCCTGTAGGGCCCGAGGGATGAGATCACTGGGTCTCACGGAGGAACAACTGCGACAACAGCTCACGGAGTGGCAGGACCT
CCACCTGAAGGAGAACGTCCCTCCTTCCCTTTTGCTCCTGTCCCGCACCTTCTACCTGATAGATGTGAAGCCCAAGCCGATTGAGATACC
ACTCAGTGGGGAGGGTCATGGAGTCCTGGAGATGCCCTCAGGCACCGGGAAGACAGTATCCCTGTTGGCCCTGATCATGGCATACCAGAG
AGCATATCCGCTGGAGGTGACCAAACTCATCTACTGCTCAAGAACTGTGCCAGAGATTGAGAAGGTGATTGAAGAGCTTCGAAAGTTGCT
CAACTTCTATGAGAAGCAGGAGGGCGAGAAGCTGCCGTTTCTGGGACTGGCTCTGAGCTCCCGCAAAAACTTGTGTATTCACCCTGAGAT
CCTGCATGCCAATGTGGTGGTTTATAGCTACCACTACCTCCTGGACCCCAAGATTGCAGACCTGGTGTCCAAGGAACTGGCCCGCAAGGC
CGTCGTGGTCTTCGACGAGGCCCACAACATTGACAACGTCTGCATCGACTCCATGAGCGTCAACCTCACCCGCCGGACCCTTGACCGGTG
CCAGGGCAACCTGGAGACCCTGCAGAAGACGGTGCTCAGGATCAAAGAGACAGACGAGCAGCGCCTGCGGGACGAGTACCGGCGTCTGGT
GGAGGGGCTGCGGGAGGCCAGCGCCGCCCGGGAGACGGACGCCCACCTGGCCAACCCCGTGCTGCCCGACGAAGTGCTGCAGGAGGCAGT
GCCTGGCTCCATCCGCACGGCCGAGCATTTCCTGGGCTTCCTGAGGCGGCTGCTGGAGTACGTGAAGTGGCGGCTGCGTGTGCAGCATGT
GGTGCAGGAGAGCCCGCCCGCCTTCCTGAGCGGCCTGGCCCAGCGCGTGTGCATCCAGCGCAAGCCCCTCAGATTCTGTGCTGAACGCCT
CCGGTCCCTGCTGCATACTCTGGAGATCACCGACCTTGCTGACTTCTCCCCGCTCACCCTCCTTGCTAACTTTGCCACCCTTGTCAGCAC
CTACGCCAAAGGCTTCACCATCATCATCGAGCCCTTTGACGACAGAACCCCGACCATTGCCAACCCCATCCTGCACTTCAGCTGCATGGA
CGCCTCGCTGGCCATCAAACCCGTATTTGAGCGTTTCCAGTCTGTCATCATCACATCTGGGACACTGTCCCCGCTGGACATCTACCCCAA
GATCCTGGACTTCCACCCCGTCACCATGGCAACCTTCACCATGACGCTGGCACGGGTCTGCCTCTGCCCTATGATCATCGGCCGTGGCAA
TGACCAGGTGGCCATCAGCTCCAAATTTGAGACCCGGGAGGATATTGCTGTGATCCGGAACTATGGGAACCTCCTGCTGGAGATGTCCGC
TGTGGTCCCTGATGGCATCGTGGCCTTCTTCACCAGCTACCAGTACATGGAGAGCACCGTGGCCTCCTGGTATGAGCAGGGGATCCTTGA
GAACATCCAGAGGAACAAGCTGCTCTTTATTGAGACCCAGGATGGTGCCGAAACCAGTGTCGCCCTGGAGAAGTACCAGGAGGCCTGCGA
GAATGGCCGCGGGGCCATCCTGCTGTCAGTGGCCCGGGGCAAAGTGTCCGAGGGAATCGACTTTGTGCACCACTACGGGCGGGCCGTCAT
CATGTTTGGCGTCCCCTACGTCTACACACAGAGCCGCATTCTCAAGGCGCGGCTGGAATACCTGCGGGACCAGTTCCAGATTCGTGAGAA
TGACTTTCTTACCTTCGATGCCATGCGCCACGCGGCCCAGTGTGTGGGTCGGGCCATCAGGGGCAAGACGGACTACGGCCTCATGGTCTT
TGCCGACAAGCGGTTTGCCCGTGGGGACAAGCGGGGGAAGCTGCCCCGCTGGATCCAGGAGCACCTCACAGATGCCAACCTCAACCTGAC
CGTGGACGAGGGTGTCCAGGTGGCCAAGTACTTCCTGCGGCAGATGGCACAGCCCTTCCACCGGGAGGATCAGCTGGGCCTGTCCCTGCT
CAGCCTGGAGCAGCTAGAATCAGAGGAGACGCTGAAGAGGATAGAGCAGATTGCTCAGCAGCTCTGAGTGGGGCGGGTGGGGCCATAAAC

>44492_44492_23_LETM2-ERCC2_LETM2_chr8_38262024_ENST00000527710_ERCC2_chr19_45872405_ENST00000391944_length(amino acids)=839AA_BP=192
MEEKQKKKMAVKLELAKFLQETMTEMARRNRAKMGDASTQLSSYVKQVQTGHKPSTKEIVRFSKLFEDQLALEHLDRPQLVALCKLLELQ
TFGTNNLLRFQLLMKLKSIKADDEIIAKEGVTALSVSELQAACRARGMRSLGLTEEQLRQQLTEWQDLHLKENVPPSLLLLSRTFYLIDV
KPKPIEIPLSGEGHGVLEMPSGTGKTVSLLALIMAYQRAYPLEVTKLIYCSRTVPEIEKVIEELRKLLNFYEKQEGEKLPFLGLALSSRK
NLCIHPEILHANVVVYSYHYLLDPKIADLVSKELARKAVVVFDEAHNIDNVCIDSMSVNLTRRTLDRCQGNLETLQKTVLRIKETDEQRL
RDEYRRLVEGLREASAARETDAHLANPVLPDEVLQEAVPGSIRTAEHFLGFLRRLLEYVKWRLRVQHVVQESPPAFLSGLAQRVCIQRKP
LRFCAERLRSLLHTLEITDLADFSPLTLLANFATLVSTYAKGFTIIIEPFDDRTPTIANPILHFSCMDASLAIKPVFERFQSVIITSGTL
SPLDIYPKILDFHPVTMATFTMTLARVCLCPMIIGRGNDQVAISSKFETREDIAVIRNYGNLLLEMSAVVPDGIVAFFTSYQYMESTVAS
WYEQGILENIQRNKLLFIETQDGAETSVALEKYQEACENGRGAILLSVARGKVSEGIDFVHHYGRAVIMFGVPYVYTQSRILKARLEYLR
DQFQIRENDFLTFDAMRHAAQCVGRAIRGKTDYGLMVFADKRFARGDKRGKLPRWIQEHLTDANLNLTVDEGVQVAKYFLRQMAQPFHRE

--------------------------------------------------------------
>44492_44492_24_LETM2-ERCC2_LETM2_chr8_38262024_ENST00000527710_ERCC2_chr19_45872405_ENST00000391945_length(transcript)=4703nt_BP=733nt
AGTAGGTATGATTTAGTCAGCCCAACAGACAGTTCAGCAGCCCCTGAGAAGAGGGAGCCTTCACTGAGTGTGGCAGTCACTGTGCCGGTG
AGAAAACAGAGGCAGCTCCTTCCTTCTCCCCGTTCTGTGCCACTCTACTAGACAGCGTTGACAGCATATGGAAGAAAAACAGAAAAAGAA
AATGGCTGTAAAGTTGGAACTAGCAAAATTTCTTCAAGAAACCATGACAGAAATGGCAAGGAGGAACAGAGCCAAGATGGGCGATGCCTC
TACACAGCTCTCATCCTACGTGAAGCAGGTCCAGACAGGCCACAAGCCCAGCACAAAGGAGATAGTTCGCTTCTCCAAACTATTTGAGGA
CCAGCTGGCCCTGGAACACTTAGATCGCCCTCAGCTGGTTGCCCTTTGCAAACTGCTGGAATTGCAGACATTTGGAACCAACAACCTGCT
CCGCTTTCAGCTCCTGATGAAACTGAAGTCTATAAAAGCAGATGATGAAATAATTGCCAAGGAAGGGGTGACAGCATTGAGTGTATCAGA
ACTACAGGCTGCCTGTAGGGCCCGAGGGATGAGATCACTGGGTCTCACGGAGGAACAACTGCGACAACAGCTCACGGAGTGGCAGGACCT
CCACCTGAAGGAGAACGTCCCTCCTTCCCTTTTGCTCCTGTCCCGCACCTTCTACCTGATAGATGTGAAGCCCAAGCCGATTGAGATACC
ACTCAGTGGGGAGGGTCATGGAGTCCTGGAGATGCCCTCAGGCACCGGGAAGACAGTATCCCTGTTGGCCCTGATCATGGCATACCAGAG
AGCATATCCGCTGGAGGTGACCAAACTCATCTACTGCTCAAGAACTGTGCCAGAGATTGAGAAGGTGATTGAAGAGCTTCGAAAGTTGCT
CAACTTCTATGAGAAGCAGGAGGGCGAGAAGCTGCCGTTTCTGGGACTGGCTCTGAGCTCCCGCAAAAACTTGTGTATTCACCCTGAGGT
GACACCCCTGCGCTTTGGGAAGGACGTCGATGGGAAATGCCACAGCCTCACAGCCTCCTATGTGCGGGCGCAGTACCAGCATGACACCAG
CCTGCCCCACTGCCGATTCTATGAGGAATTTGATGCCCATGGGCGTGAGGTGCCCCTCCCCGCTGGCATCTACAACCTGGATGACCTGAA
GGCCCTGGGGCGGCGCCAGGGCTGGTGCCCATACTTCCTTGCTCGATACTCAATCCTGCATGCCAATGTGGTGGTTTATAGCTACCACTA
CCTCCTGGACCCCAAGATTGCAGACCTGGTGTCCAAGGAACTGGCCCGCAAGGCCGTCGTGGTCTTCGACGAGGCCCACAACATTGACAA
CGTCTGCATCGACTCCATGAGCGTCAACCTCACCCGCCGGACCCTTGACCGGTGCCAGGGCAACCTGGAGACCCTGCAGAAGACGGTGCT
CAGGATCAAAGAGACAGACGAGCAGCGCCTGCGGGACGAGTACCGGCGTCTGGTGGAGGGGCTGCGGGAGGCCAGCGCCGCCCGGGAGAC
GGACGCCCACCTGGCCAACCCCGTGCTGCCCGACGAAGTGCTGCAGGAGGCAGTGCCTGGCTCCATCCGCACGGCCGAGCATTTCCTGGG
CTTCCTGAGGCGGCTGCTGGAGTACGTGAAGTGGCGGCTGCGTGTGCAGCATGTGGTGCAGGAGAGCCCGCCCGCCTTCCTGAGCGGCCT
GGCCCAGCGCGTGTGCATCCAGCGCAAGCCCCTCAGATTCTGTGCTGAACGCCTCCGGTCCCTGCTGCATACTCTGGAGATCACCGACCT
TGCTGACTTCTCCCCGCTCACCCTCCTTGCTAACTTTGCCACCCTTGTCAGCACCTACGCCAAAGGCTTCACCATCATCATCGAGCCCTT
TGACGACAGAACCCCGACCATTGCCAACCCCATCCTGCACTTCAGCTGCATGGACGCCTCGCTGGCCATCAAACCCGTATTTGAGCGTTT
CCAGTCTGTCATCATCACATCTGGGACACTGTCCCCGCTGGACATCTACCCCAAGATCCTGGACTTCCACCCCGTCACCATGGCAACCTT
CACCATGACGCTGGCACGGGTCTGCCTCTGCCCTATGATCATCGGCCGTGGCAATGACCAGGTGGCCATCAGCTCCAAATTTGAGACCCG
GGAGGATATTGCTGTGATCCGGAACTATGGGAACCTCCTGCTGGAGATGTCCGCTGTGGTCCCTGATGGCATCGTGGCCTTCTTCACCAG
CTACCAGTACATGGAGAGCACCGTGGCCTCCTGGTATGAGCAGGGGATCCTTGAGAACATCCAGAGGAACAAGCTGCTCTTTATTGAGAC
CCAGGATGGTGCCGAAACCAGTGTCGCCCTGGAGAAGTACCAGGAGGCCTGCGAGAATGGCCGCGGGGCCATCCTGCTGTCAGTGGCCCG
GGGCAAAGTGTCCGAGGGAATCGACTTTGTGCACCACTACGGGCGGGCCGTCATCATGTTTGGCGTCCCCTACGTCTACACACAGAGCCG
CATTCTCAAGGCGCGGCTGGAATACCTGCGGGACCAGTTCCAGATTCGTGAGAATGACTTTCTTACCTTCGATGCCATGCGCCACGCGGC
CCAGTGTGTGGGTCGGGCCATCAGGGGCAAGACGGACTACGGCCTCATGGTCTTTGCCGACAAGCGGTTTGCCCGTGGGGACAAGCGGGG
GAAGCTGCCCCGCTGGATCCAGGAGCACCTCACAGATGCCAACCTCAACCTGACCGTGGACGAGGGTGTCCAGGTGGCCAAGTACTTCCT
GCGGCAGATGGCACAGCCCTTCCACCGGGAGGATCAGCTGGGCCTGTCCCTGCTCAGCCTGGAGCAGCTAGAATCAGAGGAGACGCTGAA
GAGGATAGAGCAGATTGCTCAGCAGCTCTGAGTGGGGCGGGTGGGGCCATAAACGGTTCCTGGTGACTCCTGAGTCTTGCCTGGCCCTGG
TTCCCAGCGGCGGTGGTGCTAGAAGGTCTTATGAAGTCAGGTGACATTTCTCACTGTCACGTCCACAGCCTTTAATCGCAGGAGAAGGCA
GCTATCCACCAGGTACCCAGAGGCAAGGGGGGGCCAGGAGATGATAGACCCCCTCTCACCCCACCAGCCCATCCCTCCTGCACTGTTCCC
AAGAAGCTGCGGCCAGCGCAGTTCACTGGACGTTAGTGGGGGCTCAGGTCCTGGGTGCTGGCGCTGAGGGTCCGAGGGGCCTTGTCCAGG
TGCCAGCTGGGAAACTGGAGACAGGCACAGGGGATGGTTGGAGGGGAGGTGAGGGGCAAGTGTTACATCCACCCTCCAGCTCCAGGTCCA
GCCTGGCAGCCAACTATCCAACCCCCTCGCCTCTACCCCAAGTAAAACCCATCTTTGCTCCTGTCCTGGGTCTCTTCTGACACCAACCCA
CCACCTGCTGACTCCACCACTGGCCCGACCGCCCTGCCTTTGCCTCATCTCTGCACCTACCCACATGGCCTCCTCTATTTTTGACCCAGA
TGTCCCCCTCACCTGAGTCCCAGGAGCCCTTGGAGCATCCACGTTCAGTGTGTTGAGTGACATGGCTCTCTTCATTCTGCAAAGAGGGCA
GCAGGGAGGAAATGAGTGAATCCAGGAGTGGCCCCCCTCCACGAGGGACCTTTCCAGCACAGGGTTTGATCTGTGTGTATCACAGGGGAG
ATGGGAGCCATGGAAGGTTCTTGAGCAAGATGGGGGTGGGGGTGGGGTGGGCTGTGGATTCTGCTGATGTCAGGGCTCTTTGCCGACCTG
ATCAACACTCACCCGGCTGCTCCTGCCGCCGCCTCGCCTCGGAGCCGGGAGACCAGCTTCTCACTTCCTCGCCTGATAGACTCACGGATC
TTGGAGAGTGAGCTGCTGCGGCGAAGGGCCTGGGGAGGGGCCGGGGATGCTGCTCAGTCCCCCAGGCCCATGCAGTCCCCACGCCCACCC
CAGGAGCCGAAGCACAGCCCATCCTCACCTGTTCTGCGTCACCAGCTGTGCCTGTGTTGGGGGCACCTAGGGGGAAAGATGGGGGACACT
GAGATGGGGACATAGAGAAGCCACCAGGAGGGAAGACAGACAGGGGCTAGGGGCTCACCGAGAGGGGCGGGTAGGTCCTCCTTGTGGAGG
ATTTCTTTGTACAGCTCTTCCGCTTGTTGATACTTGTTCTGTTTCAGGTAGGCTGAGGCCTGCGGAGAAGGGAGTGTCTGGGAACTTTTC
GGACCCCAGTTCCCAACACTGCATCCAGTCCCGCCTTTTTTTTTTTTTTTGTAGAGACAGGGGTCTTGGTATGTTGCCCAGGCTGGTCTT
GAACTCCTAGCCTCAAGTGATCCTCCTGCCTTGGCCTCCCAAAGTGTTGGGGTTACAAGCGTGAACCACCACGTCTGGCCCCACTTTCTA
ATGTGCTGACCTGGCCGTATCCTTCCCCTGCCTAAAGCCTTGCCCTGGGGCAGAGTGGGTTTGGAGCTCGGCCTTACTTCCTGCCCTGGG
GATGGAGGACAGGCAGCCTCCTGTTTCTGAGCCTGTCTGCTGTACTTTGGGCTGGTGGCATGGCCTCGGTGCCTCAGTCTTCCCACACGC
AAAGTGGAGCGACAGCTCCCACCTCATAGGGACGCTATAAGAACTAGCGATGTGGGGACCGGGCTAAGAGGGGAGCCGGCCACAGTGAGC

>44492_44492_24_LETM2-ERCC2_LETM2_chr8_38262024_ENST00000527710_ERCC2_chr19_45872405_ENST00000391945_length(amino acids)=917AA_BP=192
MEEKQKKKMAVKLELAKFLQETMTEMARRNRAKMGDASTQLSSYVKQVQTGHKPSTKEIVRFSKLFEDQLALEHLDRPQLVALCKLLELQ
TFGTNNLLRFQLLMKLKSIKADDEIIAKEGVTALSVSELQAACRARGMRSLGLTEEQLRQQLTEWQDLHLKENVPPSLLLLSRTFYLIDV
KPKPIEIPLSGEGHGVLEMPSGTGKTVSLLALIMAYQRAYPLEVTKLIYCSRTVPEIEKVIEELRKLLNFYEKQEGEKLPFLGLALSSRK
NLCIHPEVTPLRFGKDVDGKCHSLTASYVRAQYQHDTSLPHCRFYEEFDAHGREVPLPAGIYNLDDLKALGRRQGWCPYFLARYSILHAN
VVVYSYHYLLDPKIADLVSKELARKAVVVFDEAHNIDNVCIDSMSVNLTRRTLDRCQGNLETLQKTVLRIKETDEQRLRDEYRRLVEGLR
EASAARETDAHLANPVLPDEVLQEAVPGSIRTAEHFLGFLRRLLEYVKWRLRVQHVVQESPPAFLSGLAQRVCIQRKPLRFCAERLRSLL
HTLEITDLADFSPLTLLANFATLVSTYAKGFTIIIEPFDDRTPTIANPILHFSCMDASLAIKPVFERFQSVIITSGTLSPLDIYPKILDF
HPVTMATFTMTLARVCLCPMIIGRGNDQVAISSKFETREDIAVIRNYGNLLLEMSAVVPDGIVAFFTSYQYMESTVASWYEQGILENIQR
NKLLFIETQDGAETSVALEKYQEACENGRGAILLSVARGKVSEGIDFVHHYGRAVIMFGVPYVYTQSRILKARLEYLRDQFQIRENDFLT
FDAMRHAAQCVGRAIRGKTDYGLMVFADKRFARGDKRGKLPRWIQEHLTDANLNLTVDEGVQVAKYFLRQMAQPFHREDQLGLSLLSLEQ

--------------------------------------------------------------
>44492_44492_25_LETM2-ERCC2_LETM2_chr8_38262024_ENST00000527710_ERCC2_chr19_45872405_ENST00000485403_length(transcript)=2019nt_BP=733nt
AGTAGGTATGATTTAGTCAGCCCAACAGACAGTTCAGCAGCCCCTGAGAAGAGGGAGCCTTCACTGAGTGTGGCAGTCACTGTGCCGGTG
AGAAAACAGAGGCAGCTCCTTCCTTCTCCCCGTTCTGTGCCACTCTACTAGACAGCGTTGACAGCATATGGAAGAAAAACAGAAAAAGAA
AATGGCTGTAAAGTTGGAACTAGCAAAATTTCTTCAAGAAACCATGACAGAAATGGCAAGGAGGAACAGAGCCAAGATGGGCGATGCCTC
TACACAGCTCTCATCCTACGTGAAGCAGGTCCAGACAGGCCACAAGCCCAGCACAAAGGAGATAGTTCGCTTCTCCAAACTATTTGAGGA
CCAGCTGGCCCTGGAACACTTAGATCGCCCTCAGCTGGTTGCCCTTTGCAAACTGCTGGAATTGCAGACATTTGGAACCAACAACCTGCT
CCGCTTTCAGCTCCTGATGAAACTGAAGTCTATAAAAGCAGATGATGAAATAATTGCCAAGGAAGGGGTGACAGCATTGAGTGTATCAGA
ACTACAGGCTGCCTGTAGGGCCCGAGGGATGAGATCACTGGGTCTCACGGAGGAACAACTGCGACAACAGCTCACGGAGTGGCAGGACCT
CCACCTGAAGGAGAACGTCCCTCCTTCCCTTTTGCTCCTGTCCCGCACCTTCTACCTGATAGATGTGAAGCCCAAGCCGATTGAGATACC
ACTCAGTGGGGAGGGTCATGGAGTCCTGGAGATGCCCTCAGGCACCGGGAAGACAGTATCCCTGTTGGCCCTGATCATGGCATACCAGAG
AGCATATCCGCTGGAGGTGACCAAACTCATCTACTGCTCAAGAACTGTGCCAGAGATTGAGAAGGTGATTGAAGAGCTTCGAAAGTTGCT
CAACTTCTATGAGAAGCAGGAGGGCGAGAAGCTGCCGTTTCTGGGACTGGCTCTGAGCTCCCGCAAAAACTTGTGTATTCACCCTGAGGT
GACACCCCTGCGCTTTGGGAAGGACGTCGATGGGAAATGCCACAGCCTCACAGCCTCCTATGTGCGGGCGCAGTACCAGCATGACACCAG
CCTGCCCCACTGCCGATTCTATGAGGAATTTGATGCCCATGGGCGTGAGGTGCCCCTCCCCGCTGGCATCTACAACCTGGATGACCTGAA
GGCCCTGGGGCGGCGCCAGGGCTGGTGCCCATACTTCCTTGCTCGATACTCAATCCTGCATGCCAATGTGGTGGTTTATAGCTACCACTA
CCTCCTGGACCCCAAGATTGCAGACCTGGTGTCCAAGGAACTGGCCCGCAAGGCCGTCGTGGTCTTCGACGAGGCCCACAACATTGACAA
CGTCTGCATCGACTCCATGAGCGTCAACCTCACCCGCCGGACCCTTGACCGGTGCCAGGGCAACCTGGAGACCCTGCAGAAGACGGTGCT
CAGGATCAAAGAGACAGACGAGCAGCGCCTGCGGGACGAGTACCGGCGTCTGGTGGAGGGGCTGCGGGAGGCCAGCGCCGCCCGGGAGAC
GGACGCCCACCTGGCCAACCCCGTGCTGCCCGACGAAGTGCTGCAGGAGGCAGTGCCTGGCTCCATCCGCACGGCCGAGCATTTCCTGGG
CTTCCTGAGGCGGCTGCTGGAGTACGTGAAGTGGCGGCTGCGTGTGCAGCATGTGGTGCAGGAGAGCCCGCCCGCCTTCCTGAGCGGCCT
GGCCCAGCGCGTGTGCATCCAGCGCAAGCCCCTCAGATTCTGTGCTGAACGCCTCCGGTCCCTGCTGCATACTCTGGAGATCACCGACCT
TGCTGACTTCTCCCCGCTCACCCTCCTTGCTAACTTTGCCACCCTTGTCAGCACCTACGCCAAAGGCCAGGCTCAGCACTGTGGAAGCAG
CAGGAACCAAAAAAGATCTCATCCCTAACCCCCCAGAACTTATATTCCAGATGGGAAAACCAGTAGCAAAGATGCAGCCAAATAAACAAG

>44492_44492_25_LETM2-ERCC2_LETM2_chr8_38262024_ENST00000527710_ERCC2_chr19_45872405_ENST00000485403_length(amino acids)=586AA_BP=192
MEEKQKKKMAVKLELAKFLQETMTEMARRNRAKMGDASTQLSSYVKQVQTGHKPSTKEIVRFSKLFEDQLALEHLDRPQLVALCKLLELQ
TFGTNNLLRFQLLMKLKSIKADDEIIAKEGVTALSVSELQAACRARGMRSLGLTEEQLRQQLTEWQDLHLKENVPPSLLLLSRTFYLIDV
KPKPIEIPLSGEGHGVLEMPSGTGKTVSLLALIMAYQRAYPLEVTKLIYCSRTVPEIEKVIEELRKLLNFYEKQEGEKLPFLGLALSSRK
NLCIHPEVTPLRFGKDVDGKCHSLTASYVRAQYQHDTSLPHCRFYEEFDAHGREVPLPAGIYNLDDLKALGRRQGWCPYFLARYSILHAN
VVVYSYHYLLDPKIADLVSKELARKAVVVFDEAHNIDNVCIDSMSVNLTRRTLDRCQGNLETLQKTVLRIKETDEQRLRDEYRRLVEGLR
EASAARETDAHLANPVLPDEVLQEAVPGSIRTAEHFLGFLRRLLEYVKWRLRVQHVVQESPPAFLSGLAQRVCIQRKPLRFCAERLRSLL

--------------------------------------------------------------

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Fusion Gene PPI Analysis for LETM2-ERCC2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for LETM2-ERCC2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for LETM2-ERCC2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource