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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ANKHD1-PAIP2 (FusionGDB2 ID:4454)

Fusion Gene Summary for ANKHD1-PAIP2

check button Fusion gene summary
Fusion gene informationFusion gene name: ANKHD1-PAIP2
Fusion gene ID: 4454
HgeneTgene
Gene symbol

ANKHD1

PAIP2

Gene ID

54882

51247

Gene nameankyrin repeat and KH domain containing 1poly(A) binding protein interacting protein 2
SynonymsMASK|MASK1|PP2500|VBARPPAIP-2|PAIP2A
Cytomap

5q31.3

5q31.2

Type of geneprotein-codingprotein-coding
Descriptionankyrin repeat and KH domain-containing protein 1HIV-1 Vpr-binding ankyrin repeat proteinmultiple ankyrin repeats, single KH-domain homologpolyadenylate-binding protein-interacting protein 2PABC1-interacting protein 2PABP-interacting protein 2polyA-binding protein-interacting protein 2
Modification date2020031320200313
UniProtAcc

Q8IWZ3

.
Ensembl transtripts involved in fusion geneENST00000297183, ENST00000360839, 
ENST00000394722, ENST00000394723, 
ENST00000462121, ENST00000544120, 
ENST00000394795, ENST00000510080, 
ENST00000511381, ENST00000511706, 
ENST00000265192, 
Fusion gene scores* DoF score29 X 9 X 8=208813 X 9 X 6=702
# samples 1414
** MAII scorelog2(14/2088*10)=-3.89862297962492
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(14/702*10)=-2.32604420335959
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ANKHD1 [Title/Abstract] AND PAIP2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointANKHD1(139865317)-PAIP2(138704422), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePAIP2

GO:0045947

negative regulation of translational initiation

11172725


check buttonFusion gene breakpoints across ANKHD1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PAIP2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-4357-01AANKHD1chr5

139865317

-PAIP2chr5

138704422

+


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Fusion Gene ORF analysis for ANKHD1-PAIP2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000297183ENST00000394795ANKHD1chr5

139865317

-PAIP2chr5

138704422

+
5CDS-3UTRENST00000297183ENST00000510080ANKHD1chr5

139865317

-PAIP2chr5

138704422

+
5CDS-3UTRENST00000297183ENST00000511381ANKHD1chr5

139865317

-PAIP2chr5

138704422

+
5CDS-3UTRENST00000297183ENST00000511706ANKHD1chr5

139865317

-PAIP2chr5

138704422

+
5CDS-3UTRENST00000360839ENST00000394795ANKHD1chr5

139865317

-PAIP2chr5

138704422

+
5CDS-3UTRENST00000360839ENST00000510080ANKHD1chr5

139865317

-PAIP2chr5

138704422

+
5CDS-3UTRENST00000360839ENST00000511381ANKHD1chr5

139865317

-PAIP2chr5

138704422

+
5CDS-3UTRENST00000360839ENST00000511706ANKHD1chr5

139865317

-PAIP2chr5

138704422

+
In-frameENST00000297183ENST00000265192ANKHD1chr5

139865317

-PAIP2chr5

138704422

+
In-frameENST00000360839ENST00000265192ANKHD1chr5

139865317

-PAIP2chr5

138704422

+
intron-3CDSENST00000394722ENST00000265192ANKHD1chr5

139865317

-PAIP2chr5

138704422

+
intron-3CDSENST00000394723ENST00000265192ANKHD1chr5

139865317

-PAIP2chr5

138704422

+
intron-3CDSENST00000462121ENST00000265192ANKHD1chr5

139865317

-PAIP2chr5

138704422

+
intron-3CDSENST00000544120ENST00000265192ANKHD1chr5

139865317

-PAIP2chr5

138704422

+
intron-3UTRENST00000394722ENST00000394795ANKHD1chr5

139865317

-PAIP2chr5

138704422

+
intron-3UTRENST00000394722ENST00000510080ANKHD1chr5

139865317

-PAIP2chr5

138704422

+
intron-3UTRENST00000394722ENST00000511381ANKHD1chr5

139865317

-PAIP2chr5

138704422

+
intron-3UTRENST00000394722ENST00000511706ANKHD1chr5

139865317

-PAIP2chr5

138704422

+
intron-3UTRENST00000394723ENST00000394795ANKHD1chr5

139865317

-PAIP2chr5

138704422

+
intron-3UTRENST00000394723ENST00000510080ANKHD1chr5

139865317

-PAIP2chr5

138704422

+
intron-3UTRENST00000394723ENST00000511381ANKHD1chr5

139865317

-PAIP2chr5

138704422

+
intron-3UTRENST00000394723ENST00000511706ANKHD1chr5

139865317

-PAIP2chr5

138704422

+
intron-3UTRENST00000462121ENST00000394795ANKHD1chr5

139865317

-PAIP2chr5

138704422

+
intron-3UTRENST00000462121ENST00000510080ANKHD1chr5

139865317

-PAIP2chr5

138704422

+
intron-3UTRENST00000462121ENST00000511381ANKHD1chr5

139865317

-PAIP2chr5

138704422

+
intron-3UTRENST00000462121ENST00000511706ANKHD1chr5

139865317

-PAIP2chr5

138704422

+
intron-3UTRENST00000544120ENST00000394795ANKHD1chr5

139865317

-PAIP2chr5

138704422

+
intron-3UTRENST00000544120ENST00000510080ANKHD1chr5

139865317

-PAIP2chr5

138704422

+
intron-3UTRENST00000544120ENST00000511381ANKHD1chr5

139865317

-PAIP2chr5

138704422

+
intron-3UTRENST00000544120ENST00000511706ANKHD1chr5

139865317

-PAIP2chr5

138704422

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000360839ANKHD1chr5139865317-ENST00000265192PAIP2chr5138704422+326222961542361735
ENST00000297183ANKHD1chr5139865317-ENST00000265192PAIP2chr5138704422+323222661242331735

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000360839ENST00000265192ANKHD1chr5139865317-PAIP2chr5138704422+0.0035285830.9964714
ENST00000297183ENST00000265192ANKHD1chr5139865317-PAIP2chr5138704422+0.0032363460.9967636

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Fusion Genomic Features for ANKHD1-PAIP2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ANKHD1-PAIP2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:139865317/chr5:138704422)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ANKHD1

Q8IWZ3

.
FUNCTION: May play a role as a scaffolding protein that may be associated with the abnormal phenotype of leukemia cells. Isoform 2 may possess an antiapoptotic effect and protect cells during normal cell survival through its regulation of caspases. {ECO:0000269|PubMed:16098192}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneANKHD1chr5:139865317chr5:138704422ENST00000297183-13366_947142618.0Compositional biasNote=Gly-rich
HgeneANKHD1chr5:139865317chr5:138704422ENST00000360839-13346_947142543.0Compositional biasNote=Gly-rich
HgeneANKHD1chr5:139865317chr5:138704422ENST00000297183-1336204_2337142618.0RepeatNote=ANK 1
HgeneANKHD1chr5:139865317chr5:138704422ENST00000297183-1336237_2667142618.0RepeatNote=ANK 2
HgeneANKHD1chr5:139865317chr5:138704422ENST00000297183-1336271_3007142618.0RepeatNote=ANK 3
HgeneANKHD1chr5:139865317chr5:138704422ENST00000297183-1336304_3337142618.0RepeatNote=ANK 4
HgeneANKHD1chr5:139865317chr5:138704422ENST00000297183-1336337_3667142618.0RepeatNote=ANK 5
HgeneANKHD1chr5:139865317chr5:138704422ENST00000297183-1336371_4007142618.0RepeatNote=ANK 6
HgeneANKHD1chr5:139865317chr5:138704422ENST00000297183-1336404_4337142618.0RepeatNote=ANK 7
HgeneANKHD1chr5:139865317chr5:138704422ENST00000297183-1336437_4667142618.0RepeatNote=ANK 8
HgeneANKHD1chr5:139865317chr5:138704422ENST00000297183-1336470_4997142618.0RepeatNote=ANK 9
HgeneANKHD1chr5:139865317chr5:138704422ENST00000297183-1336504_5337142618.0RepeatNote=ANK 10
HgeneANKHD1chr5:139865317chr5:138704422ENST00000297183-1336534_5637142618.0RepeatNote=ANK 11
HgeneANKHD1chr5:139865317chr5:138704422ENST00000297183-1336567_5967142618.0RepeatNote=ANK 12
HgeneANKHD1chr5:139865317chr5:138704422ENST00000297183-1336600_6297142618.0RepeatNote=ANK 13
HgeneANKHD1chr5:139865317chr5:138704422ENST00000297183-1336634_6637142618.0RepeatNote=ANK 14
HgeneANKHD1chr5:139865317chr5:138704422ENST00000297183-1336667_6967142618.0RepeatNote=ANK 15
HgeneANKHD1chr5:139865317chr5:138704422ENST00000360839-1334204_2337142543.0RepeatNote=ANK 1
HgeneANKHD1chr5:139865317chr5:138704422ENST00000360839-1334237_2667142543.0RepeatNote=ANK 2
HgeneANKHD1chr5:139865317chr5:138704422ENST00000360839-1334271_3007142543.0RepeatNote=ANK 3
HgeneANKHD1chr5:139865317chr5:138704422ENST00000360839-1334304_3337142543.0RepeatNote=ANK 4
HgeneANKHD1chr5:139865317chr5:138704422ENST00000360839-1334337_3667142543.0RepeatNote=ANK 5
HgeneANKHD1chr5:139865317chr5:138704422ENST00000360839-1334371_4007142543.0RepeatNote=ANK 6
HgeneANKHD1chr5:139865317chr5:138704422ENST00000360839-1334404_4337142543.0RepeatNote=ANK 7
HgeneANKHD1chr5:139865317chr5:138704422ENST00000360839-1334437_4667142543.0RepeatNote=ANK 8
HgeneANKHD1chr5:139865317chr5:138704422ENST00000360839-1334470_4997142543.0RepeatNote=ANK 9
HgeneANKHD1chr5:139865317chr5:138704422ENST00000360839-1334504_5337142543.0RepeatNote=ANK 10
HgeneANKHD1chr5:139865317chr5:138704422ENST00000360839-1334534_5637142543.0RepeatNote=ANK 11
HgeneANKHD1chr5:139865317chr5:138704422ENST00000360839-1334567_5967142543.0RepeatNote=ANK 12
HgeneANKHD1chr5:139865317chr5:138704422ENST00000360839-1334600_6297142543.0RepeatNote=ANK 13
HgeneANKHD1chr5:139865317chr5:138704422ENST00000360839-1334634_6637142543.0RepeatNote=ANK 14
HgeneANKHD1chr5:139865317chr5:138704422ENST00000360839-1334667_6967142543.0RepeatNote=ANK 15
TgenePAIP2chr5:139865317chr5:138704422ENST0000026519224105_120106128.0RegionNote=PABPC1-interacting motif-2 (PAM2)
TgenePAIP2chr5:139865317chr5:138704422ENST0000039479524105_120106128.0RegionNote=PABPC1-interacting motif-2 (PAM2)
TgenePAIP2chr5:139865317chr5:138704422ENST0000051008024105_120106128.0RegionNote=PABPC1-interacting motif-2 (PAM2)

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneANKHD1chr5:139865317chr5:138704422ENST00000297183-13361415_14857142618.0Coiled coilOntology_term=ECO:0000255
HgeneANKHD1chr5:139865317chr5:138704422ENST00000297183-1336775_8527142618.0Coiled coilOntology_term=ECO:0000255
HgeneANKHD1chr5:139865317chr5:138704422ENST00000360839-13341415_14857142543.0Coiled coilOntology_term=ECO:0000255
HgeneANKHD1chr5:139865317chr5:138704422ENST00000360839-1334775_8527142543.0Coiled coilOntology_term=ECO:0000255
HgeneANKHD1chr5:139865317chr5:138704422ENST00000394722-1111415_14850617.0Coiled coilOntology_term=ECO:0000255
HgeneANKHD1chr5:139865317chr5:138704422ENST00000394722-111775_8520617.0Coiled coilOntology_term=ECO:0000255
HgeneANKHD1chr5:139865317chr5:138704422ENST00000394723-1111415_14850628.0Coiled coilOntology_term=ECO:0000255
HgeneANKHD1chr5:139865317chr5:138704422ENST00000394723-111775_8520628.0Coiled coilOntology_term=ECO:0000255
HgeneANKHD1chr5:139865317chr5:138704422ENST00000297183-13361977_21007142618.0Compositional biasNote=Ser-rich
HgeneANKHD1chr5:139865317chr5:138704422ENST00000297183-13362291_22997142618.0Compositional biasNote=Poly-Ser
HgeneANKHD1chr5:139865317chr5:138704422ENST00000360839-13341977_21007142543.0Compositional biasNote=Ser-rich
HgeneANKHD1chr5:139865317chr5:138704422ENST00000360839-13342291_22997142543.0Compositional biasNote=Poly-Ser
HgeneANKHD1chr5:139865317chr5:138704422ENST00000394722-1111977_21000617.0Compositional biasNote=Ser-rich
HgeneANKHD1chr5:139865317chr5:138704422ENST00000394722-1112291_22990617.0Compositional biasNote=Poly-Ser
HgeneANKHD1chr5:139865317chr5:138704422ENST00000394722-1116_940617.0Compositional biasNote=Gly-rich
HgeneANKHD1chr5:139865317chr5:138704422ENST00000394723-1111977_21000628.0Compositional biasNote=Ser-rich
HgeneANKHD1chr5:139865317chr5:138704422ENST00000394723-1112291_22990628.0Compositional biasNote=Poly-Ser
HgeneANKHD1chr5:139865317chr5:138704422ENST00000394723-1116_940628.0Compositional biasNote=Gly-rich
HgeneANKHD1chr5:139865317chr5:138704422ENST00000297183-13361695_17597142618.0DomainKH
HgeneANKHD1chr5:139865317chr5:138704422ENST00000360839-13341695_17597142543.0DomainKH
HgeneANKHD1chr5:139865317chr5:138704422ENST00000394722-1111695_17590617.0DomainKH
HgeneANKHD1chr5:139865317chr5:138704422ENST00000394723-1111695_17590628.0DomainKH
HgeneANKHD1chr5:139865317chr5:138704422ENST00000297183-13361054_10837142618.0RepeatNote=ANK 16
HgeneANKHD1chr5:139865317chr5:138704422ENST00000297183-13361087_11167142618.0RepeatNote=ANK 17
HgeneANKHD1chr5:139865317chr5:138704422ENST00000297183-13361121_11507142618.0RepeatNote=ANK 18
HgeneANKHD1chr5:139865317chr5:138704422ENST00000297183-13361154_11837142618.0RepeatNote=ANK 19
HgeneANKHD1chr5:139865317chr5:138704422ENST00000297183-13361189_12187142618.0RepeatNote=ANK 20
HgeneANKHD1chr5:139865317chr5:138704422ENST00000297183-13361223_12527142618.0RepeatNote=ANK 21
HgeneANKHD1chr5:139865317chr5:138704422ENST00000297183-13361256_12857142618.0RepeatNote=ANK 22
HgeneANKHD1chr5:139865317chr5:138704422ENST00000297183-13361291_13207142618.0RepeatNote=ANK 23
HgeneANKHD1chr5:139865317chr5:138704422ENST00000297183-13361324_13537142618.0RepeatNote=ANK 24
HgeneANKHD1chr5:139865317chr5:138704422ENST00000297183-13361357_13867142618.0RepeatNote=ANK 25
HgeneANKHD1chr5:139865317chr5:138704422ENST00000360839-13341054_10837142543.0RepeatNote=ANK 16
HgeneANKHD1chr5:139865317chr5:138704422ENST00000360839-13341087_11167142543.0RepeatNote=ANK 17
HgeneANKHD1chr5:139865317chr5:138704422ENST00000360839-13341121_11507142543.0RepeatNote=ANK 18
HgeneANKHD1chr5:139865317chr5:138704422ENST00000360839-13341154_11837142543.0RepeatNote=ANK 19
HgeneANKHD1chr5:139865317chr5:138704422ENST00000360839-13341189_12187142543.0RepeatNote=ANK 20
HgeneANKHD1chr5:139865317chr5:138704422ENST00000360839-13341223_12527142543.0RepeatNote=ANK 21
HgeneANKHD1chr5:139865317chr5:138704422ENST00000360839-13341256_12857142543.0RepeatNote=ANK 22
HgeneANKHD1chr5:139865317chr5:138704422ENST00000360839-13341291_13207142543.0RepeatNote=ANK 23
HgeneANKHD1chr5:139865317chr5:138704422ENST00000360839-13341324_13537142543.0RepeatNote=ANK 24
HgeneANKHD1chr5:139865317chr5:138704422ENST00000360839-13341357_13867142543.0RepeatNote=ANK 25
HgeneANKHD1chr5:139865317chr5:138704422ENST00000394722-1111054_10830617.0RepeatNote=ANK 16
HgeneANKHD1chr5:139865317chr5:138704422ENST00000394722-1111087_11160617.0RepeatNote=ANK 17
HgeneANKHD1chr5:139865317chr5:138704422ENST00000394722-1111121_11500617.0RepeatNote=ANK 18
HgeneANKHD1chr5:139865317chr5:138704422ENST00000394722-1111154_11830617.0RepeatNote=ANK 19
HgeneANKHD1chr5:139865317chr5:138704422ENST00000394722-1111189_12180617.0RepeatNote=ANK 20
HgeneANKHD1chr5:139865317chr5:138704422ENST00000394722-1111223_12520617.0RepeatNote=ANK 21
HgeneANKHD1chr5:139865317chr5:138704422ENST00000394722-1111256_12850617.0RepeatNote=ANK 22
HgeneANKHD1chr5:139865317chr5:138704422ENST00000394722-1111291_13200617.0RepeatNote=ANK 23
HgeneANKHD1chr5:139865317chr5:138704422ENST00000394722-1111324_13530617.0RepeatNote=ANK 24
HgeneANKHD1chr5:139865317chr5:138704422ENST00000394722-1111357_13860617.0RepeatNote=ANK 25
HgeneANKHD1chr5:139865317chr5:138704422ENST00000394722-111204_2330617.0RepeatNote=ANK 1
HgeneANKHD1chr5:139865317chr5:138704422ENST00000394722-111237_2660617.0RepeatNote=ANK 2
HgeneANKHD1chr5:139865317chr5:138704422ENST00000394722-111271_3000617.0RepeatNote=ANK 3
HgeneANKHD1chr5:139865317chr5:138704422ENST00000394722-111304_3330617.0RepeatNote=ANK 4
HgeneANKHD1chr5:139865317chr5:138704422ENST00000394722-111337_3660617.0RepeatNote=ANK 5
HgeneANKHD1chr5:139865317chr5:138704422ENST00000394722-111371_4000617.0RepeatNote=ANK 6
HgeneANKHD1chr5:139865317chr5:138704422ENST00000394722-111404_4330617.0RepeatNote=ANK 7
HgeneANKHD1chr5:139865317chr5:138704422ENST00000394722-111437_4660617.0RepeatNote=ANK 8
HgeneANKHD1chr5:139865317chr5:138704422ENST00000394722-111470_4990617.0RepeatNote=ANK 9
HgeneANKHD1chr5:139865317chr5:138704422ENST00000394722-111504_5330617.0RepeatNote=ANK 10
HgeneANKHD1chr5:139865317chr5:138704422ENST00000394722-111534_5630617.0RepeatNote=ANK 11
HgeneANKHD1chr5:139865317chr5:138704422ENST00000394722-111567_5960617.0RepeatNote=ANK 12
HgeneANKHD1chr5:139865317chr5:138704422ENST00000394722-111600_6290617.0RepeatNote=ANK 13
HgeneANKHD1chr5:139865317chr5:138704422ENST00000394722-111634_6630617.0RepeatNote=ANK 14
HgeneANKHD1chr5:139865317chr5:138704422ENST00000394722-111667_6960617.0RepeatNote=ANK 15
HgeneANKHD1chr5:139865317chr5:138704422ENST00000394723-1111054_10830628.0RepeatNote=ANK 16
HgeneANKHD1chr5:139865317chr5:138704422ENST00000394723-1111087_11160628.0RepeatNote=ANK 17
HgeneANKHD1chr5:139865317chr5:138704422ENST00000394723-1111121_11500628.0RepeatNote=ANK 18
HgeneANKHD1chr5:139865317chr5:138704422ENST00000394723-1111154_11830628.0RepeatNote=ANK 19
HgeneANKHD1chr5:139865317chr5:138704422ENST00000394723-1111189_12180628.0RepeatNote=ANK 20
HgeneANKHD1chr5:139865317chr5:138704422ENST00000394723-1111223_12520628.0RepeatNote=ANK 21
HgeneANKHD1chr5:139865317chr5:138704422ENST00000394723-1111256_12850628.0RepeatNote=ANK 22
HgeneANKHD1chr5:139865317chr5:138704422ENST00000394723-1111291_13200628.0RepeatNote=ANK 23
HgeneANKHD1chr5:139865317chr5:138704422ENST00000394723-1111324_13530628.0RepeatNote=ANK 24
HgeneANKHD1chr5:139865317chr5:138704422ENST00000394723-1111357_13860628.0RepeatNote=ANK 25
HgeneANKHD1chr5:139865317chr5:138704422ENST00000394723-111204_2330628.0RepeatNote=ANK 1
HgeneANKHD1chr5:139865317chr5:138704422ENST00000394723-111237_2660628.0RepeatNote=ANK 2
HgeneANKHD1chr5:139865317chr5:138704422ENST00000394723-111271_3000628.0RepeatNote=ANK 3
HgeneANKHD1chr5:139865317chr5:138704422ENST00000394723-111304_3330628.0RepeatNote=ANK 4
HgeneANKHD1chr5:139865317chr5:138704422ENST00000394723-111337_3660628.0RepeatNote=ANK 5
HgeneANKHD1chr5:139865317chr5:138704422ENST00000394723-111371_4000628.0RepeatNote=ANK 6
HgeneANKHD1chr5:139865317chr5:138704422ENST00000394723-111404_4330628.0RepeatNote=ANK 7
HgeneANKHD1chr5:139865317chr5:138704422ENST00000394723-111437_4660628.0RepeatNote=ANK 8
HgeneANKHD1chr5:139865317chr5:138704422ENST00000394723-111470_4990628.0RepeatNote=ANK 9
HgeneANKHD1chr5:139865317chr5:138704422ENST00000394723-111504_5330628.0RepeatNote=ANK 10
HgeneANKHD1chr5:139865317chr5:138704422ENST00000394723-111534_5630628.0RepeatNote=ANK 11
HgeneANKHD1chr5:139865317chr5:138704422ENST00000394723-111567_5960628.0RepeatNote=ANK 12
HgeneANKHD1chr5:139865317chr5:138704422ENST00000394723-111600_6290628.0RepeatNote=ANK 13
HgeneANKHD1chr5:139865317chr5:138704422ENST00000394723-111634_6630628.0RepeatNote=ANK 14
HgeneANKHD1chr5:139865317chr5:138704422ENST00000394723-111667_6960628.0RepeatNote=ANK 15
TgenePAIP2chr5:139865317chr5:138704422ENST000002651922433_72106128.0Compositional biasNote=Glu-rich
TgenePAIP2chr5:139865317chr5:138704422ENST000003947952433_72106128.0Compositional biasNote=Glu-rich
TgenePAIP2chr5:139865317chr5:138704422ENST000005100802433_72106128.0Compositional biasNote=Glu-rich
TgenePAIP2chr5:139865317chr5:138704422ENST000002651922422_75106128.0RegionNote=PABPC1-interacting motif-1 (PAM1)
TgenePAIP2chr5:139865317chr5:138704422ENST000003947952422_75106128.0RegionNote=PABPC1-interacting motif-1 (PAM1)
TgenePAIP2chr5:139865317chr5:138704422ENST000005100802422_75106128.0RegionNote=PABPC1-interacting motif-1 (PAM1)


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Fusion Gene Sequence for ANKHD1-PAIP2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>4454_4454_1_ANKHD1-PAIP2_ANKHD1_chr5_139865317_ENST00000297183_PAIP2_chr5_138704422_ENST00000265192_length(transcript)=3232nt_BP=2266nt
AGTGGCGCTGCTGGGACGGGGGAAAGGAGACGCTTCTTCCTCTTGCTGCTCTTCTCGTTCCCGAGATCAGCGGCGGCGGTGACCGCGAGT
GGGTCGGCACCGTCTCCGGCTCCGGGTGCGAACAATGCTGACTGATAGCGGAGGCGGCGGCACCTCCTTTGAGGAGGACCTGGACTCTGT
GGCTCCGCGATCCGCCCCAGCTGGGGCCTCGGAGCCGCCTCCGCCGGGAGGGGTCGGTCTGGGGATCCGCACCGTGAGGCTCTTTGGGGA
GGCCGGGCCAGCGTCGGGAGTCGGCAGCAGCGGCGGCGGCGGCAGCGGCAGCGGTACGGGCGGAGGGGACGCGGCGCTGGATTTCAAGTT
GGCGGCTGCCGTGCTGAGGACCGGGGGTGGAGGTGGTGCCTCTGGCAGTGACGAGGACGAAGTGTCCGAGGTTGAATCATTTATTTTGGA
CCAAGAAGATCTGGATAACCCAGTGCTTAAAACAACATCAGAGATATTCTTATCAAGTACTGCAGAAGGAGCAGACTTACGCACTGTGGA
TCCAGAGACACAGGCACGACTAGAAGCATTGCTAGAAGCAGCAGGAATTGGCAAATTGTCAACTGCTGATGGTAAAGCTTTTGCAGATCC
TGAGGTACTCCGGAGACTGACATCCTCAGTTAGTTGTGCACTGGATGAAGCTGCTGCTGCACTGACACGGATGAAAGCAGAAAACAGCCA
CAATGCAGGACAAGTGGACACTCGCAGTCTAGCAGAAGCTTGTTCAGATGGGGATGTTAATGCTGTTCGTAAATTGCTAGATGAAGGCAG
AAGTGTAAATGAACATACAGAAGAAGGAGAAAGCCTGCTGTGTTTGGCTTGTTCAGCAGGGTATTATGAATTAGCACAAGTATTGCTTGC
TATGCATGCTAATGTTGAAGATCGAGGGAATAAAGGAGACATAACTCCCCTGATGGCAGCTTCCAGTGGAGGTTACTTAGATATTGTGAA
ATTATTACTTCTTCATGATGCTGATGTCAACTCCCAGTCTGCAACAGGAAACACTGCGCTAACTTATGCATGTGCTGGAGGATTTGTTGA
CATTGTTAAAGTGCTCCTTAATGAAGGTGCAAATATAGAAGATCATAATGAAAATGGACATACTCCCTTAATGGAAGCAGCCAGTGCAGG
TCATGTGGAAGTTGCAAGAGTTCTTTTAGATCATGGTGCAGGCATCAACACTCATTCTAATGAATTCAAAGAAAGTGCTCTAACACTTGC
TTGCTACAAAGGCCATTTGGATATGGTTCGCTTTCTACTTGAAGCTGGTGCAGATCAAGAGCACAAAACAGATGAGATGCACACTGCCTT
AATGGAGGCCTGCATGGATGGACATGTAGAGGTGGCACGTTTGCTTTTGGATAGTGGTGCTCAAGTGAACATGCCTGCAGATTCATTTGA
ATCTCCATTGACGCTAGCTGCCTGTGGAGGACATGTTGAATTGGCAGCTCTACTTATTGAAAGGGGAGCAAATCTTGAAGAAGTTAATGA
TGAAGGATACACTCCCTTGATGGAAGCTGCCCGGGAAGGACATGAAGAAATGGTGGCACTACTCTTAGCACAAGGAGCAAATATAAATGC
CCAGACAGAAGAAACTCAAGAAACTGCTCTTACTTTGGCTTGCTGTGGAGGATTTTCTGAAGTTGCAGACTTTCTTATTAAGGCAGGGGC
TGATATAGAACTTGGCTGCTCCACACCTCTGATGGAGGCATCTCAGGAGGGACACCTGGAATTGGTTAAATATTTGCTGGCTTCTGGCGC
TAATGTGCATGCTACAACAGCAACAGGAGACACAGCCTTAACCTATGCTTGTGAAAATGGACATACGGATGTTGCAGATGTTTTACTTCA
AGCAGGGGCTGATTTAGAACATGAATCTGAAGGTGGAAGAACACCTTTGATGAAAGCTGCAAGAGCTGGTCATTTGTGCACTGTGCAGTT
TCTTATTAGCAAAGGTGCCAATGTTAACAGGGCTACAGCCAATAATGATCATACAGTAGTGTCGCTGGCATGTGCAGGAGGCCACCTGGC
AGTTGTTGAGCTTCTCTTGGCTCATGGGGCTGACCCTACTCATCGACTCAAGGATGGTTCAACAATGCTCATTGAAGCTGCAAAGGGTGG
CCATACTAATGTAGTTTCTTATCTGTTGGATTATCCAAATAATGTTCTGTCAGTTCCCACCACAGATGTGTCTCAGCTCCCTCCACCTTC
TCAAGATCAGTCTCAGGTCAAGAGCAATCTGAATCCAAATGCAAAGGAGTTTGTTCCTGGGGTGAAGTACGGAAATATTTGAGTAGACGG
GGCCCTCTTTTGGTGGATGTAGCACAATTTCCACACTGTGAAGGCAGTATTAGAAGACTTAATTGTAAAAGCTCTCTTGTCACTGTGTTA
CACTTATGCATTGCCAAAGTTTTTGTTAGTCTTGCATGCTTAATAAAAGTGCTGAGACTGTTACTAAGTAAAAAGCTGTCAAACATTTAC
TGAAAATAGAATTGGCCCCATGGCTTGATGTGAAGACAGCAAGGAAAGAAGCACCAGTCAAGTTGTGAACAAGCACCAAATTAAAAGACC
TAAACCTTACCAAATTGTCTTTTTTTGAGGCTAATCTATCACTTGTTAATGTCTAAACTTTAAAATCAGTACATTTAATTTGAGTTCCAA
CTGTTAAGCATATTTCTCAGACTTAAATTTGATTATGTCCCCATCAAAAAGAATCTCCATTTTCTGAAGGTCTGTTAGTTAATTTGAGAT
AATTTGTTAAAGGCAAGTATGTCATATTACTGAGGCTACAAGTTAGTCAGCAGATGAGTGCCAGTCCAGCCTTTTCTGGTATGTTATTGT
TAGAAATATTGAGTTCTAATGTTACATCTGAGGAAGTATGTAATTTGAGAATTGTAACTTCTAAGGGATTCACTGCATCATAGCTATGCC
TGTATGGAGTCTAACATATGACCAATACCAACCCATAATCCAGCTGAACAAAGATACTGTAACATGATTTGAGTGGTGCTTTTCCTTGCT
TTGTTAACCATCACGAGAGTCTGCAGCACAACTTTTAACAAAGCTAGAACAGTTTTGGCTTCTTAAACTTCATATTTGGGTAGGTTAAGC

>4454_4454_1_ANKHD1-PAIP2_ANKHD1_chr5_139865317_ENST00000297183_PAIP2_chr5_138704422_ENST00000265192_length(amino acids)=735AA_BP=713
MLTDSGGGGTSFEEDLDSVAPRSAPAGASEPPPPGGVGLGIRTVRLFGEAGPASGVGSSGGGGSGSGTGGGDAALDFKLAAAVLRTGGGG
GASGSDEDEVSEVESFILDQEDLDNPVLKTTSEIFLSSTAEGADLRTVDPETQARLEALLEAAGIGKLSTADGKAFADPEVLRRLTSSVS
CALDEAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNK
GDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDH
GAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGH
VELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLM
EASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRA
TANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLDYPNNVLSVPTTDVSQLPPPSQDQSQVKSNLN

--------------------------------------------------------------
>4454_4454_2_ANKHD1-PAIP2_ANKHD1_chr5_139865317_ENST00000360839_PAIP2_chr5_138704422_ENST00000265192_length(transcript)=3262nt_BP=2296nt
GGGAGGCAGCAGGTTAGGCAGTGAGAAGTTAGTGGCGCTGCTGGGACGGGGGAAAGGAGACGCTTCTTCCTCTTGCTGCTCTTCTCGTTC
CCGAGATCAGCGGCGGCGGTGACCGCGAGTGGGTCGGCACCGTCTCCGGCTCCGGGTGCGAACAATGCTGACTGATAGCGGAGGCGGCGG
CACCTCCTTTGAGGAGGACCTGGACTCTGTGGCTCCGCGATCCGCCCCAGCTGGGGCCTCGGAGCCGCCTCCGCCGGGAGGGGTCGGTCT
GGGGATCCGCACCGTGAGGCTCTTTGGGGAGGCCGGGCCAGCGTCGGGAGTCGGCAGCAGCGGCGGCGGCGGCAGCGGCAGCGGTACGGG
CGGAGGGGACGCGGCGCTGGATTTCAAGTTGGCGGCTGCCGTGCTGAGGACCGGGGGTGGAGGTGGTGCCTCTGGCAGTGACGAGGACGA
AGTGTCCGAGGTTGAATCATTTATTTTGGACCAAGAAGATCTGGATAACCCAGTGCTTAAAACAACATCAGAGATATTCTTATCAAGTAC
TGCAGAAGGAGCAGACTTACGCACTGTGGATCCAGAGACACAGGCACGACTAGAAGCATTGCTAGAAGCAGCAGGAATTGGCAAATTGTC
AACTGCTGATGGTAAAGCTTTTGCAGATCCTGAGGTACTCCGGAGACTGACATCCTCAGTTAGTTGTGCACTGGATGAAGCTGCTGCTGC
ACTGACACGGATGAAAGCAGAAAACAGCCACAATGCAGGACAAGTGGACACTCGCAGTCTAGCAGAAGCTTGTTCAGATGGGGATGTTAA
TGCTGTTCGTAAATTGCTAGATGAAGGCAGAAGTGTAAATGAACATACAGAAGAAGGAGAAAGCCTGCTGTGTTTGGCTTGTTCAGCAGG
GTATTATGAATTAGCACAAGTATTGCTTGCTATGCATGCTAATGTTGAAGATCGAGGGAATAAAGGAGACATAACTCCCCTGATGGCAGC
TTCCAGTGGAGGTTACTTAGATATTGTGAAATTATTACTTCTTCATGATGCTGATGTCAACTCCCAGTCTGCAACAGGAAACACTGCGCT
AACTTATGCATGTGCTGGAGGATTTGTTGACATTGTTAAAGTGCTCCTTAATGAAGGTGCAAATATAGAAGATCATAATGAAAATGGACA
TACTCCCTTAATGGAAGCAGCCAGTGCAGGTCATGTGGAAGTTGCAAGAGTTCTTTTAGATCATGGTGCAGGCATCAACACTCATTCTAA
TGAATTCAAAGAAAGTGCTCTAACACTTGCTTGCTACAAAGGCCATTTGGATATGGTTCGCTTTCTACTTGAAGCTGGTGCAGATCAAGA
GCACAAAACAGATGAGATGCACACTGCCTTAATGGAGGCCTGCATGGATGGACATGTAGAGGTGGCACGTTTGCTTTTGGATAGTGGTGC
TCAAGTGAACATGCCTGCAGATTCATTTGAATCTCCATTGACGCTAGCTGCCTGTGGAGGACATGTTGAATTGGCAGCTCTACTTATTGA
AAGGGGAGCAAATCTTGAAGAAGTTAATGATGAAGGATACACTCCCTTGATGGAAGCTGCCCGGGAAGGACATGAAGAAATGGTGGCACT
ACTCTTAGCACAAGGAGCAAATATAAATGCCCAGACAGAAGAAACTCAAGAAACTGCTCTTACTTTGGCTTGCTGTGGAGGATTTTCTGA
AGTTGCAGACTTTCTTATTAAGGCAGGGGCTGATATAGAACTTGGCTGCTCCACACCTCTGATGGAGGCATCTCAGGAGGGACACCTGGA
ATTGGTTAAATATTTGCTGGCTTCTGGCGCTAATGTGCATGCTACAACAGCAACAGGAGACACAGCCTTAACCTATGCTTGTGAAAATGG
ACATACGGATGTTGCAGATGTTTTACTTCAAGCAGGGGCTGATTTAGAACATGAATCTGAAGGTGGAAGAACACCTTTGATGAAAGCTGC
AAGAGCTGGTCATTTGTGCACTGTGCAGTTTCTTATTAGCAAAGGTGCCAATGTTAACAGGGCTACAGCCAATAATGATCATACAGTAGT
GTCGCTGGCATGTGCAGGAGGCCACCTGGCAGTTGTTGAGCTTCTCTTGGCTCATGGGGCTGACCCTACTCATCGACTCAAGGATGGTTC
AACAATGCTCATTGAAGCTGCAAAGGGTGGCCATACTAATGTAGTTTCTTATCTGTTGGATTATCCAAATAATGTTCTGTCAGTTCCCAC
CACAGATGTGTCTCAGCTCCCTCCACCTTCTCAAGATCAGTCTCAGGTCAAGAGCAATCTGAATCCAAATGCAAAGGAGTTTGTTCCTGG
GGTGAAGTACGGAAATATTTGAGTAGACGGGGCCCTCTTTTGGTGGATGTAGCACAATTTCCACACTGTGAAGGCAGTATTAGAAGACTT
AATTGTAAAAGCTCTCTTGTCACTGTGTTACACTTATGCATTGCCAAAGTTTTTGTTAGTCTTGCATGCTTAATAAAAGTGCTGAGACTG
TTACTAAGTAAAAAGCTGTCAAACATTTACTGAAAATAGAATTGGCCCCATGGCTTGATGTGAAGACAGCAAGGAAAGAAGCACCAGTCA
AGTTGTGAACAAGCACCAAATTAAAAGACCTAAACCTTACCAAATTGTCTTTTTTTGAGGCTAATCTATCACTTGTTAATGTCTAAACTT
TAAAATCAGTACATTTAATTTGAGTTCCAACTGTTAAGCATATTTCTCAGACTTAAATTTGATTATGTCCCCATCAAAAAGAATCTCCAT
TTTCTGAAGGTCTGTTAGTTAATTTGAGATAATTTGTTAAAGGCAAGTATGTCATATTACTGAGGCTACAAGTTAGTCAGCAGATGAGTG
CCAGTCCAGCCTTTTCTGGTATGTTATTGTTAGAAATATTGAGTTCTAATGTTACATCTGAGGAAGTATGTAATTTGAGAATTGTAACTT
CTAAGGGATTCACTGCATCATAGCTATGCCTGTATGGAGTCTAACATATGACCAATACCAACCCATAATCCAGCTGAACAAAGATACTGT
AACATGATTTGAGTGGTGCTTTTCCTTGCTTTGTTAACCATCACGAGAGTCTGCAGCACAACTTTTAACAAAGCTAGAACAGTTTTGGCT
TCTTAAACTTCATATTTGGGTAGGTTAAGCTGCCATACGTGTTCAGTGTGAATAGTGTTTAAGTTGAAAATATTGTAAAAAAATTATATT

>4454_4454_2_ANKHD1-PAIP2_ANKHD1_chr5_139865317_ENST00000360839_PAIP2_chr5_138704422_ENST00000265192_length(amino acids)=735AA_BP=713
MLTDSGGGGTSFEEDLDSVAPRSAPAGASEPPPPGGVGLGIRTVRLFGEAGPASGVGSSGGGGSGSGTGGGDAALDFKLAAAVLRTGGGG
GASGSDEDEVSEVESFILDQEDLDNPVLKTTSEIFLSSTAEGADLRTVDPETQARLEALLEAAGIGKLSTADGKAFADPEVLRRLTSSVS
CALDEAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNK
GDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDH
GAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGH
VELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLM
EASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRA
TANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLDYPNNVLSVPTTDVSQLPPPSQDQSQVKSNLN

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ANKHD1-PAIP2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ANKHD1-PAIP2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ANKHD1-PAIP2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource