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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:LGR5-CNOT2 (FusionGDB2 ID:44591)

Fusion Gene Summary for LGR5-CNOT2

check button Fusion gene summary
Fusion gene informationFusion gene name: LGR5-CNOT2
Fusion gene ID: 44591
HgeneTgene
Gene symbol

LGR5

CNOT2

Gene ID

8549

4848

Gene nameleucine rich repeat containing G protein-coupled receptor 5CCR4-NOT transcription complex subunit 2
SynonymsFEX|GPR49|GPR67|GRP49|HG38CDC36|HSPC131|IDNADFS|NOT2|NOT2H
Cytomap

12q21.1

12q15

Type of geneprotein-codingprotein-coding
Descriptionleucine-rich repeat-containing G-protein coupled receptor 5G-protein coupled receptor 49G-protein coupled receptor 67G-protein coupled receptor HG38orphan G protein-coupled receptor HG38CCR4-NOT transcription complex subunit 2CCR4-associated factor 2negative regulator of transcription 2
Modification date2020032920200313
UniProtAcc

O75473

Q9NZN8

Ensembl transtripts involved in fusion geneENST00000266674, ENST00000536515, 
ENST00000540815, 		ENST00000548230, 
ENST00000551483, ENST00000229195, 
ENST00000418359, 
Fusion gene scores* DoF score5 X 3 X 2=3027 X 20 X 10=5400
# samples 529
** MAII scorelog2(5/30*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(29/5400*10)=-4.21883460192326
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: LGR5 [Title/Abstract] AND CNOT2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointLGR5(71928966)-CNOT2(70747609), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneLGR5

GO:0090263

positive regulation of canonical Wnt signaling pathway

21693646|22815884

TgeneCNOT2

GO:0000122

negative regulation of transcription by RNA polymerase II

14707134|16712523


check buttonFusion gene breakpoints across LGR5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CNOT2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-ZF-AA4U-01ALGR5chr12

71928966

-CNOT2chr12

70747609

+
ChimerDB4BLCATCGA-ZF-AA4U-01ALGR5chr12

71928966

+CNOT2chr12

70747609

+
ChimerDB4BLCATCGA-ZF-AA4ULGR5chr12

71928966

+CNOT2chr12

70747608

+


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Fusion Gene ORF analysis for LGR5-CNOT2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000266674ENST00000548230LGR5chr12

71928966

+CNOT2chr12

70747609

+
5CDS-intronENST00000266674ENST00000548230LGR5chr12

71928966

+CNOT2chr12

70747608

+
5CDS-intronENST00000266674ENST00000551483LGR5chr12

71928966

+CNOT2chr12

70747609

+
5CDS-intronENST00000266674ENST00000551483LGR5chr12

71928966

+CNOT2chr12

70747608

+
5CDS-intronENST00000536515ENST00000548230LGR5chr12

71928966

+CNOT2chr12

70747609

+
5CDS-intronENST00000536515ENST00000548230LGR5chr12

71928966

+CNOT2chr12

70747608

+
5CDS-intronENST00000536515ENST00000551483LGR5chr12

71928966

+CNOT2chr12

70747609

+
5CDS-intronENST00000536515ENST00000551483LGR5chr12

71928966

+CNOT2chr12

70747608

+
5CDS-intronENST00000540815ENST00000548230LGR5chr12

71928966

+CNOT2chr12

70747609

+
5CDS-intronENST00000540815ENST00000548230LGR5chr12

71928966

+CNOT2chr12

70747608

+
5CDS-intronENST00000540815ENST00000551483LGR5chr12

71928966

+CNOT2chr12

70747609

+
5CDS-intronENST00000540815ENST00000551483LGR5chr12

71928966

+CNOT2chr12

70747608

+
In-frameENST00000266674ENST00000229195LGR5chr12

71928966

+CNOT2chr12

70747609

+
In-frameENST00000266674ENST00000229195LGR5chr12

71928966

+CNOT2chr12

70747608

+
In-frameENST00000266674ENST00000418359LGR5chr12

71928966

+CNOT2chr12

70747609

+
In-frameENST00000266674ENST00000418359LGR5chr12

71928966

+CNOT2chr12

70747608

+
In-frameENST00000536515ENST00000229195LGR5chr12

71928966

+CNOT2chr12

70747609

+
In-frameENST00000536515ENST00000229195LGR5chr12

71928966

+CNOT2chr12

70747608

+
In-frameENST00000536515ENST00000418359LGR5chr12

71928966

+CNOT2chr12

70747609

+
In-frameENST00000536515ENST00000418359LGR5chr12

71928966

+CNOT2chr12

70747608

+
In-frameENST00000540815ENST00000229195LGR5chr12

71928966

+CNOT2chr12

70747609

+
In-frameENST00000540815ENST00000229195LGR5chr12

71928966

+CNOT2chr12

70747608

+
In-frameENST00000540815ENST00000418359LGR5chr12

71928966

+CNOT2chr12

70747609

+
In-frameENST00000540815ENST00000418359LGR5chr12

71928966

+CNOT2chr12

70747608

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000266674LGR5chr1271928966+ENST00000229195CNOT2chr1270747608+190473973660195
ENST00000266674LGR5chr1271928966+ENST00000418359CNOT2chr1270747608+190473973660195
ENST00000536515LGR5chr1271928966+ENST00000229195CNOT2chr1270747608+164147648503151
ENST00000536515LGR5chr1271928966+ENST00000418359CNOT2chr1270747608+164147648503151
ENST00000540815LGR5chr1271928966+ENST00000229195CNOT2chr1270747608+163947446501151
ENST00000540815LGR5chr1271928966+ENST00000418359CNOT2chr1270747608+163947446501151
ENST00000266674LGR5chr1271928966+ENST00000229195CNOT2chr1270747609+190473973660195
ENST00000266674LGR5chr1271928966+ENST00000418359CNOT2chr1270747609+190473973660195
ENST00000536515LGR5chr1271928966+ENST00000229195CNOT2chr1270747609+164147648503151
ENST00000536515LGR5chr1271928966+ENST00000418359CNOT2chr1270747609+164147648503151
ENST00000540815LGR5chr1271928966+ENST00000229195CNOT2chr1270747609+163947446501151
ENST00000540815LGR5chr1271928966+ENST00000418359CNOT2chr1270747609+163947446501151

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000266674ENST00000229195LGR5chr1271928966+CNOT2chr1270747608+0.035109420.96489054
ENST00000266674ENST00000418359LGR5chr1271928966+CNOT2chr1270747608+0.035109420.96489054
ENST00000536515ENST00000229195LGR5chr1271928966+CNOT2chr1270747608+0.0231155120.97688454
ENST00000536515ENST00000418359LGR5chr1271928966+CNOT2chr1270747608+0.0231155120.97688454
ENST00000540815ENST00000229195LGR5chr1271928966+CNOT2chr1270747608+0.0198026820.9801973
ENST00000540815ENST00000418359LGR5chr1271928966+CNOT2chr1270747608+0.0198026820.9801973
ENST00000266674ENST00000229195LGR5chr1271928966+CNOT2chr1270747609+0.035109420.96489054
ENST00000266674ENST00000418359LGR5chr1271928966+CNOT2chr1270747609+0.035109420.96489054
ENST00000536515ENST00000229195LGR5chr1271928966+CNOT2chr1270747609+0.0231155120.97688454
ENST00000536515ENST00000418359LGR5chr1271928966+CNOT2chr1270747609+0.0231155120.97688454
ENST00000540815ENST00000229195LGR5chr1271928966+CNOT2chr1270747609+0.0198026820.9801973
ENST00000540815ENST00000418359LGR5chr1271928966+CNOT2chr1270747609+0.0198026820.9801973

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Fusion Genomic Features for LGR5-CNOT2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
LGR5chr1271928966+CNOT2chr1270747608+0.0001203550.9998796
LGR5chr1271928966+CNOT2chr1270747608+0.0001203550.9998796
LGR5chr1271928966+CNOT2chr1270747608+0.0001203550.9998796
LGR5chr1271928966+CNOT2chr1270747608+0.0001203550.9998796

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for LGR5-CNOT2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:71928966/chr12:70747609)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LGR5

O75473

CNOT2

Q9NZN8

FUNCTION: Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Involved in the development and/or maintenance of the adult intestinal stem cells during postembryonic development. {ECO:0000269|PubMed:21693646, ECO:0000269|PubMed:21727895, ECO:0000269|PubMed:21909076, ECO:0000269|PubMed:22815884, ECO:0000269|PubMed:23809763}.FUNCTION: Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Required for the CCR4-NOT complex structural integrity. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may specifically involve the N-Cor repressor complex containing HDAC3, NCOR1 and NCOR2. Involved in the maintenance of embryonic stem (ES) cell identity. {ECO:0000269|PubMed:14707134, ECO:0000269|PubMed:16712523, ECO:0000269|PubMed:21299754, ECO:0000269|PubMed:22367759}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLGR5chr12:71928966chr12:70747608ENST00000266674+41825_66142908.0DomainNote=LRRNT
HgeneLGR5chr12:71928966chr12:70747608ENST00000540815+41725_66142884.0DomainNote=LRRNT
HgeneLGR5chr12:71928966chr12:70747609ENST00000266674+41825_66142908.0DomainNote=LRRNT
HgeneLGR5chr12:71928966chr12:70747609ENST00000540815+41725_66142884.0DomainNote=LRRNT
HgeneLGR5chr12:71928966chr12:70747608ENST00000266674+418115_136142908.0RepeatNote=LRR 3
HgeneLGR5chr12:71928966chr12:70747608ENST00000266674+41867_90142908.0RepeatNote=LRR 1
HgeneLGR5chr12:71928966chr12:70747608ENST00000266674+41891_112142908.0RepeatNote=LRR 2
HgeneLGR5chr12:71928966chr12:70747608ENST00000540815+417115_136142884.0RepeatNote=LRR 3
HgeneLGR5chr12:71928966chr12:70747608ENST00000540815+41767_90142884.0RepeatNote=LRR 1
HgeneLGR5chr12:71928966chr12:70747608ENST00000540815+41791_112142884.0RepeatNote=LRR 2
HgeneLGR5chr12:71928966chr12:70747609ENST00000266674+418115_136142908.0RepeatNote=LRR 3
HgeneLGR5chr12:71928966chr12:70747609ENST00000266674+41867_90142908.0RepeatNote=LRR 1
HgeneLGR5chr12:71928966chr12:70747609ENST00000266674+41891_112142908.0RepeatNote=LRR 2
HgeneLGR5chr12:71928966chr12:70747609ENST00000540815+417115_136142884.0RepeatNote=LRR 3
HgeneLGR5chr12:71928966chr12:70747609ENST00000540815+41767_90142884.0RepeatNote=LRR 1
HgeneLGR5chr12:71928966chr12:70747609ENST00000540815+41791_112142884.0RepeatNote=LRR 2
TgeneCNOT2chr12:71928966chr12:70747608ENST0000055148357437_540163192.0RegionNote=Repressor domain
TgeneCNOT2chr12:71928966chr12:70747609ENST0000055148357437_540163192.0RegionNote=Repressor domain

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLGR5chr12:71928966chr12:70747608ENST00000266674+418139_160142908.0RepeatNote=LRR 4
HgeneLGR5chr12:71928966chr12:70747608ENST00000266674+418163_184142908.0RepeatNote=LRR 5
HgeneLGR5chr12:71928966chr12:70747608ENST00000266674+418187_208142908.0RepeatNote=LRR 6
HgeneLGR5chr12:71928966chr12:70747608ENST00000266674+418211_232142908.0RepeatNote=LRR 7
HgeneLGR5chr12:71928966chr12:70747608ENST00000266674+418235_256142908.0RepeatNote=LRR 8
HgeneLGR5chr12:71928966chr12:70747608ENST00000266674+418258_279142908.0RepeatNote=LRR 9
HgeneLGR5chr12:71928966chr12:70747608ENST00000266674+418282_303142908.0RepeatNote=LRR 10
HgeneLGR5chr12:71928966chr12:70747608ENST00000266674+418306_328142908.0RepeatNote=LRR 11
HgeneLGR5chr12:71928966chr12:70747608ENST00000266674+418329_350142908.0RepeatNote=LRR 12
HgeneLGR5chr12:71928966chr12:70747608ENST00000266674+418353_374142908.0RepeatNote=LRR 13
HgeneLGR5chr12:71928966chr12:70747608ENST00000266674+418375_396142908.0RepeatNote=LRR 14
HgeneLGR5chr12:71928966chr12:70747608ENST00000266674+418399_420142908.0RepeatNote=LRR 15
HgeneLGR5chr12:71928966chr12:70747608ENST00000266674+418423_446142908.0RepeatNote=LRR 16
HgeneLGR5chr12:71928966chr12:70747608ENST00000540815+417139_160142884.0RepeatNote=LRR 4
HgeneLGR5chr12:71928966chr12:70747608ENST00000540815+417163_184142884.0RepeatNote=LRR 5
HgeneLGR5chr12:71928966chr12:70747608ENST00000540815+417187_208142884.0RepeatNote=LRR 6
HgeneLGR5chr12:71928966chr12:70747608ENST00000540815+417211_232142884.0RepeatNote=LRR 7
HgeneLGR5chr12:71928966chr12:70747608ENST00000540815+417235_256142884.0RepeatNote=LRR 8
HgeneLGR5chr12:71928966chr12:70747608ENST00000540815+417258_279142884.0RepeatNote=LRR 9
HgeneLGR5chr12:71928966chr12:70747608ENST00000540815+417282_303142884.0RepeatNote=LRR 10
HgeneLGR5chr12:71928966chr12:70747608ENST00000540815+417306_328142884.0RepeatNote=LRR 11
HgeneLGR5chr12:71928966chr12:70747608ENST00000540815+417329_350142884.0RepeatNote=LRR 12
HgeneLGR5chr12:71928966chr12:70747608ENST00000540815+417353_374142884.0RepeatNote=LRR 13
HgeneLGR5chr12:71928966chr12:70747608ENST00000540815+417375_396142884.0RepeatNote=LRR 14
HgeneLGR5chr12:71928966chr12:70747608ENST00000540815+417399_420142884.0RepeatNote=LRR 15
HgeneLGR5chr12:71928966chr12:70747608ENST00000540815+417423_446142884.0RepeatNote=LRR 16
HgeneLGR5chr12:71928966chr12:70747609ENST00000266674+418139_160142908.0RepeatNote=LRR 4
HgeneLGR5chr12:71928966chr12:70747609ENST00000266674+418163_184142908.0RepeatNote=LRR 5
HgeneLGR5chr12:71928966chr12:70747609ENST00000266674+418187_208142908.0RepeatNote=LRR 6
HgeneLGR5chr12:71928966chr12:70747609ENST00000266674+418211_232142908.0RepeatNote=LRR 7
HgeneLGR5chr12:71928966chr12:70747609ENST00000266674+418235_256142908.0RepeatNote=LRR 8
HgeneLGR5chr12:71928966chr12:70747609ENST00000266674+418258_279142908.0RepeatNote=LRR 9
HgeneLGR5chr12:71928966chr12:70747609ENST00000266674+418282_303142908.0RepeatNote=LRR 10
HgeneLGR5chr12:71928966chr12:70747609ENST00000266674+418306_328142908.0RepeatNote=LRR 11
HgeneLGR5chr12:71928966chr12:70747609ENST00000266674+418329_350142908.0RepeatNote=LRR 12
HgeneLGR5chr12:71928966chr12:70747609ENST00000266674+418353_374142908.0RepeatNote=LRR 13
HgeneLGR5chr12:71928966chr12:70747609ENST00000266674+418375_396142908.0RepeatNote=LRR 14
HgeneLGR5chr12:71928966chr12:70747609ENST00000266674+418399_420142908.0RepeatNote=LRR 15
HgeneLGR5chr12:71928966chr12:70747609ENST00000266674+418423_446142908.0RepeatNote=LRR 16
HgeneLGR5chr12:71928966chr12:70747609ENST00000540815+417139_160142884.0RepeatNote=LRR 4
HgeneLGR5chr12:71928966chr12:70747609ENST00000540815+417163_184142884.0RepeatNote=LRR 5
HgeneLGR5chr12:71928966chr12:70747609ENST00000540815+417187_208142884.0RepeatNote=LRR 6
HgeneLGR5chr12:71928966chr12:70747609ENST00000540815+417211_232142884.0RepeatNote=LRR 7
HgeneLGR5chr12:71928966chr12:70747609ENST00000540815+417235_256142884.0RepeatNote=LRR 8
HgeneLGR5chr12:71928966chr12:70747609ENST00000540815+417258_279142884.0RepeatNote=LRR 9
HgeneLGR5chr12:71928966chr12:70747609ENST00000540815+417282_303142884.0RepeatNote=LRR 10
HgeneLGR5chr12:71928966chr12:70747609ENST00000540815+417306_328142884.0RepeatNote=LRR 11
HgeneLGR5chr12:71928966chr12:70747609ENST00000540815+417329_350142884.0RepeatNote=LRR 12
HgeneLGR5chr12:71928966chr12:70747609ENST00000540815+417353_374142884.0RepeatNote=LRR 13
HgeneLGR5chr12:71928966chr12:70747609ENST00000540815+417375_396142884.0RepeatNote=LRR 14
HgeneLGR5chr12:71928966chr12:70747609ENST00000540815+417399_420142884.0RepeatNote=LRR 15
HgeneLGR5chr12:71928966chr12:70747609ENST00000540815+417423_446142884.0RepeatNote=LRR 16
HgeneLGR5chr12:71928966chr12:70747608ENST00000266674+41822_561142908.0Topological domainExtracellular
HgeneLGR5chr12:71928966chr12:70747608ENST00000266674+418583_593142908.0Topological domainCytoplasmic
HgeneLGR5chr12:71928966chr12:70747608ENST00000266674+418615_638142908.0Topological domainExtracellular
HgeneLGR5chr12:71928966chr12:70747608ENST00000266674+418660_682142908.0Topological domainCytoplasmic
HgeneLGR5chr12:71928966chr12:70747608ENST00000266674+418704_722142908.0Topological domainExtracellular
HgeneLGR5chr12:71928966chr12:70747608ENST00000266674+418744_767142908.0Topological domainCytoplasmic
HgeneLGR5chr12:71928966chr12:70747608ENST00000266674+418789_802142908.0Topological domainExtracellular
HgeneLGR5chr12:71928966chr12:70747608ENST00000266674+418824_907142908.0Topological domainCytoplasmic
HgeneLGR5chr12:71928966chr12:70747608ENST00000540815+41722_561142884.0Topological domainExtracellular
HgeneLGR5chr12:71928966chr12:70747608ENST00000540815+417583_593142884.0Topological domainCytoplasmic
HgeneLGR5chr12:71928966chr12:70747608ENST00000540815+417615_638142884.0Topological domainExtracellular
HgeneLGR5chr12:71928966chr12:70747608ENST00000540815+417660_682142884.0Topological domainCytoplasmic
HgeneLGR5chr12:71928966chr12:70747608ENST00000540815+417704_722142884.0Topological domainExtracellular
HgeneLGR5chr12:71928966chr12:70747608ENST00000540815+417744_767142884.0Topological domainCytoplasmic
HgeneLGR5chr12:71928966chr12:70747608ENST00000540815+417789_802142884.0Topological domainExtracellular
HgeneLGR5chr12:71928966chr12:70747608ENST00000540815+417824_907142884.0Topological domainCytoplasmic
HgeneLGR5chr12:71928966chr12:70747609ENST00000266674+41822_561142908.0Topological domainExtracellular
HgeneLGR5chr12:71928966chr12:70747609ENST00000266674+418583_593142908.0Topological domainCytoplasmic
HgeneLGR5chr12:71928966chr12:70747609ENST00000266674+418615_638142908.0Topological domainExtracellular
HgeneLGR5chr12:71928966chr12:70747609ENST00000266674+418660_682142908.0Topological domainCytoplasmic
HgeneLGR5chr12:71928966chr12:70747609ENST00000266674+418704_722142908.0Topological domainExtracellular
HgeneLGR5chr12:71928966chr12:70747609ENST00000266674+418744_767142908.0Topological domainCytoplasmic
HgeneLGR5chr12:71928966chr12:70747609ENST00000266674+418789_802142908.0Topological domainExtracellular
HgeneLGR5chr12:71928966chr12:70747609ENST00000266674+418824_907142908.0Topological domainCytoplasmic
HgeneLGR5chr12:71928966chr12:70747609ENST00000540815+41722_561142884.0Topological domainExtracellular
HgeneLGR5chr12:71928966chr12:70747609ENST00000540815+417583_593142884.0Topological domainCytoplasmic
HgeneLGR5chr12:71928966chr12:70747609ENST00000540815+417615_638142884.0Topological domainExtracellular
HgeneLGR5chr12:71928966chr12:70747609ENST00000540815+417660_682142884.0Topological domainCytoplasmic
HgeneLGR5chr12:71928966chr12:70747609ENST00000540815+417704_722142884.0Topological domainExtracellular
HgeneLGR5chr12:71928966chr12:70747609ENST00000540815+417744_767142884.0Topological domainCytoplasmic
HgeneLGR5chr12:71928966chr12:70747609ENST00000540815+417789_802142884.0Topological domainExtracellular
HgeneLGR5chr12:71928966chr12:70747609ENST00000540815+417824_907142884.0Topological domainCytoplasmic
HgeneLGR5chr12:71928966chr12:70747608ENST00000266674+418562_582142908.0TransmembraneHelical%3B Name%3D1
HgeneLGR5chr12:71928966chr12:70747608ENST00000266674+418594_614142908.0TransmembraneHelical%3B Name%3D2
HgeneLGR5chr12:71928966chr12:70747608ENST00000266674+418639_659142908.0TransmembraneHelical%3B Name%3D3
HgeneLGR5chr12:71928966chr12:70747608ENST00000266674+418683_703142908.0TransmembraneHelical%3B Name%3D4
HgeneLGR5chr12:71928966chr12:70747608ENST00000266674+418723_743142908.0TransmembraneHelical%3B Name%3D5
HgeneLGR5chr12:71928966chr12:70747608ENST00000266674+418768_788142908.0TransmembraneHelical%3B Name%3D6
HgeneLGR5chr12:71928966chr12:70747608ENST00000266674+418803_823142908.0TransmembraneHelical%3B Name%3D7
HgeneLGR5chr12:71928966chr12:70747608ENST00000540815+417562_582142884.0TransmembraneHelical%3B Name%3D1
HgeneLGR5chr12:71928966chr12:70747608ENST00000540815+417594_614142884.0TransmembraneHelical%3B Name%3D2
HgeneLGR5chr12:71928966chr12:70747608ENST00000540815+417639_659142884.0TransmembraneHelical%3B Name%3D3
HgeneLGR5chr12:71928966chr12:70747608ENST00000540815+417683_703142884.0TransmembraneHelical%3B Name%3D4
HgeneLGR5chr12:71928966chr12:70747608ENST00000540815+417723_743142884.0TransmembraneHelical%3B Name%3D5
HgeneLGR5chr12:71928966chr12:70747608ENST00000540815+417768_788142884.0TransmembraneHelical%3B Name%3D6
HgeneLGR5chr12:71928966chr12:70747608ENST00000540815+417803_823142884.0TransmembraneHelical%3B Name%3D7
HgeneLGR5chr12:71928966chr12:70747609ENST00000266674+418562_582142908.0TransmembraneHelical%3B Name%3D1
HgeneLGR5chr12:71928966chr12:70747609ENST00000266674+418594_614142908.0TransmembraneHelical%3B Name%3D2
HgeneLGR5chr12:71928966chr12:70747609ENST00000266674+418639_659142908.0TransmembraneHelical%3B Name%3D3
HgeneLGR5chr12:71928966chr12:70747609ENST00000266674+418683_703142908.0TransmembraneHelical%3B Name%3D4
HgeneLGR5chr12:71928966chr12:70747609ENST00000266674+418723_743142908.0TransmembraneHelical%3B Name%3D5
HgeneLGR5chr12:71928966chr12:70747609ENST00000266674+418768_788142908.0TransmembraneHelical%3B Name%3D6
HgeneLGR5chr12:71928966chr12:70747609ENST00000266674+418803_823142908.0TransmembraneHelical%3B Name%3D7
HgeneLGR5chr12:71928966chr12:70747609ENST00000540815+417562_582142884.0TransmembraneHelical%3B Name%3D1
HgeneLGR5chr12:71928966chr12:70747609ENST00000540815+417594_614142884.0TransmembraneHelical%3B Name%3D2
HgeneLGR5chr12:71928966chr12:70747609ENST00000540815+417639_659142884.0TransmembraneHelical%3B Name%3D3
HgeneLGR5chr12:71928966chr12:70747609ENST00000540815+417683_703142884.0TransmembraneHelical%3B Name%3D4
HgeneLGR5chr12:71928966chr12:70747609ENST00000540815+417723_743142884.0TransmembraneHelical%3B Name%3D5
HgeneLGR5chr12:71928966chr12:70747609ENST00000540815+417768_788142884.0TransmembraneHelical%3B Name%3D6
HgeneLGR5chr12:71928966chr12:70747609ENST00000540815+417803_823142884.0TransmembraneHelical%3B Name%3D7
TgeneCNOT2chr12:71928966chr12:70747608ENST000002291951416437_540512541.0RegionNote=Repressor domain
TgeneCNOT2chr12:71928966chr12:70747608ENST000004183591517437_540512541.0RegionNote=Repressor domain
TgeneCNOT2chr12:71928966chr12:70747609ENST000002291951416437_540512541.0RegionNote=Repressor domain
TgeneCNOT2chr12:71928966chr12:70747609ENST000004183591517437_540512541.0RegionNote=Repressor domain


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Fusion Gene Sequence for LGR5-CNOT2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>44591_44591_1_LGR5-CNOT2_LGR5_chr12_71928966_ENST00000266674_CNOT2_chr12_70747608_ENST00000229195_length(transcript)=1904nt_BP=739nt
AAAAAACGAGCGTGCAAGCAGAGATGCTGCTCCACACCGCTCAGGCCGCGAGCAGCAGCAAGGCGCACCGCCACTGTCGCCGCTGCAGCC
AGGGCTGCTCCGAAGGCCGGCGTGGCGGCAACCGGCACCTCTGTCCCCGCCGCGCTTCTCCTCGCCGCCCACGCCGTGGGGTCAGGAACG
CGGCGTCTGGCGCTGCAGACGCCCGCTGAGTTGCAGAAGCCCACGGAGCGGCGCCCGGCGCGCCACGGCCCGTAGCAGTCCGGTGCTGCT
CTCCGCCCGCGTCCGGCTCGTGGCCCCCTACTTCGGGCACCATGGACACCTCCCGGCTCGGTGTGCTCCTGTCCTTGCCTGTGCTGCTGC
AGCTGGCGACCGGGGGCAGCTCTCCCAGGTCTGGTGTGTTGCTGAGGGGCTGCCCCACACACTGTCATTGCGAGCCCGACGGCAGGATGT
TGCTCAGGGTGGACTGCTCCGACCTGGGGCTCTCGGAGCTGCCTTCCAACCTCAGCGTCTTCACCTCCTACCTAGACCTCAGTATGAACA
ACATCAGTCAGCTGCTCCCGAATCCCCTGCCCAGTCTCCGCTTCCTGGAGGAGTTACGTCTTGCGGGAAACGCTCTGACATACATTCCCA
AGGGAGCATTCACTGGCCTTTACAGTCTTAAAGTTCTTATGCTGCAGAATAATCAGCTAAGACACGTACCCACAGAAGCTCTGCAGAATT
TGCGAAGCCTTCAATCCCTGAGTTCCATCTGGAATATGACAAATTAGAAGAACGGCCTCACCTGCCATCCACCTTCAACTACAACCCTGC
TCAGCAAGCCTTCTAAAAAAAAAAAAAAAAAAAAAAAAAGACTTCCCTTTTCTTGGGGTATGGCTGTCTCAGCACAATACTCAACATAAC
TGCAGAACTGATGTGGCTCAGGCACCCTGGTTTTAATTCCTTGAGGATCTGGCAATTGGCTTACGCAAAAGGTCACCATTTGAGGTCCTG
CCTTACTAATTATGTGCTGCCCAACAACTAAATTTGTAATTTGTTTTTCTCTAGTTTGAGCAGGGTCTGAATTTTTTCATTTATTTCCTT
TTTTGCCAGCAGACAGACTTGAGTCTGTAAAGACAAGCAAATACACTGACAGAAGTTTACCATAGTTTCTAAAATGTAAAAAAGAAAACC
CCCAAAAGACTCAAGAAAATTAGACCACAAATTTTGCATTGTTCATTGTAGCACTATTGGTAATAAAATAACAAATGTTTGTGCATTTTT
ATGTGAAGATCCTTCTCGTATTTCATTTGGAAAGATGAGCAAGAGGTCTGCTTCCTTCATTTTACTTCCCCTTCTGTTTTTGAAAGGCAG
TTTCGCCAAGCTTAATGCAAGAATATCTGACTGTTTAGAAGAAAGATATTGCCACAATCTCTGGATGGTTTTCCAGGGTTGTGTTATTAC
TGAGCTTCATCTTTCCAGAATGAGCAAAACACTGTCCAGTCTTTGTTACGATTTTGTAATAAATGTGTACATTTTTTTTAAATTTTTGGA
CATCACATGAATAAAGGTATGTATGTACGAATGTGTATATATTATATATATGACATCTATTTTGGAAAATGTTTGCCCTGCTGTACCTCA
TTTTTAGGAGGTGTGCATGGATGCAATATATGAAAATGGGACATTCTGGAACTGCTGGTCAGGGGACTTTGTCGCCCTGTGCACTAAAAG
GGCCAGATTTTCAGCAGCCAAGGACATCCATACCCAAGTGAATGTGATGGGACTTAAAAGAAGTGAACTGAGACAATTCACTCTGGCTGT
TTGAACAGCAGCGTTTCATAGGAAGAGAAAAAAAGATCAATCTTGTATTTTCTGACCACATAAAGGCTTCTTCTCTTTGTAATAAAGTAG

>44591_44591_1_LGR5-CNOT2_LGR5_chr12_71928966_ENST00000266674_CNOT2_chr12_70747608_ENST00000229195_length(amino acids)=195AA_BP=
MSPLQPGLLRRPAWRQPAPLSPPRFSSPPTPWGQERGVWRCRRPLSCRSPRSGARRATARSSPVLLSARVRLVAPYFGHHGHLPARCAPV
LACAAAAGDRGQLSQVWCVAEGLPHTLSLRARRQDVAQGGLLRPGALGAAFQPQRLHLLPRPQYEQHQSAAPESPAQSPLPGGVTSCGKR

--------------------------------------------------------------
>44591_44591_2_LGR5-CNOT2_LGR5_chr12_71928966_ENST00000266674_CNOT2_chr12_70747608_ENST00000418359_length(transcript)=1904nt_BP=739nt
AAAAAACGAGCGTGCAAGCAGAGATGCTGCTCCACACCGCTCAGGCCGCGAGCAGCAGCAAGGCGCACCGCCACTGTCGCCGCTGCAGCC
AGGGCTGCTCCGAAGGCCGGCGTGGCGGCAACCGGCACCTCTGTCCCCGCCGCGCTTCTCCTCGCCGCCCACGCCGTGGGGTCAGGAACG
CGGCGTCTGGCGCTGCAGACGCCCGCTGAGTTGCAGAAGCCCACGGAGCGGCGCCCGGCGCGCCACGGCCCGTAGCAGTCCGGTGCTGCT
CTCCGCCCGCGTCCGGCTCGTGGCCCCCTACTTCGGGCACCATGGACACCTCCCGGCTCGGTGTGCTCCTGTCCTTGCCTGTGCTGCTGC
AGCTGGCGACCGGGGGCAGCTCTCCCAGGTCTGGTGTGTTGCTGAGGGGCTGCCCCACACACTGTCATTGCGAGCCCGACGGCAGGATGT
TGCTCAGGGTGGACTGCTCCGACCTGGGGCTCTCGGAGCTGCCTTCCAACCTCAGCGTCTTCACCTCCTACCTAGACCTCAGTATGAACA
ACATCAGTCAGCTGCTCCCGAATCCCCTGCCCAGTCTCCGCTTCCTGGAGGAGTTACGTCTTGCGGGAAACGCTCTGACATACATTCCCA
AGGGAGCATTCACTGGCCTTTACAGTCTTAAAGTTCTTATGCTGCAGAATAATCAGCTAAGACACGTACCCACAGAAGCTCTGCAGAATT
TGCGAAGCCTTCAATCCCTGAGTTCCATCTGGAATATGACAAATTAGAAGAACGGCCTCACCTGCCATCCACCTTCAACTACAACCCTGC
TCAGCAAGCCTTCTAAAAAAAAAAAAAAAAAAAAAAAAAGACTTCCCTTTTCTTGGGGTATGGCTGTCTCAGCACAATACTCAACATAAC
TGCAGAACTGATGTGGCTCAGGCACCCTGGTTTTAATTCCTTGAGGATCTGGCAATTGGCTTACGCAAAAGGTCACCATTTGAGGTCCTG
CCTTACTAATTATGTGCTGCCCAACAACTAAATTTGTAATTTGTTTTTCTCTAGTTTGAGCAGGGTCTGAATTTTTTCATTTATTTCCTT
TTTTGCCAGCAGACAGACTTGAGTCTGTAAAGACAAGCAAATACACTGACAGAAGTTTACCATAGTTTCTAAAATGTAAAAAAGAAAACC
CCCAAAAGACTCAAGAAAATTAGACCACAAATTTTGCATTGTTCATTGTAGCACTATTGGTAATAAAATAACAAATGTTTGTGCATTTTT
ATGTGAAGATCCTTCTCGTATTTCATTTGGAAAGATGAGCAAGAGGTCTGCTTCCTTCATTTTACTTCCCCTTCTGTTTTTGAAAGGCAG
TTTCGCCAAGCTTAATGCAAGAATATCTGACTGTTTAGAAGAAAGATATTGCCACAATCTCTGGATGGTTTTCCAGGGTTGTGTTATTAC
TGAGCTTCATCTTTCCAGAATGAGCAAAACACTGTCCAGTCTTTGTTACGATTTTGTAATAAATGTGTACATTTTTTTTAAATTTTTGGA
CATCACATGAATAAAGGTATGTATGTACGAATGTGTATATATTATATATATGACATCTATTTTGGAAAATGTTTGCCCTGCTGTACCTCA
TTTTTAGGAGGTGTGCATGGATGCAATATATGAAAATGGGACATTCTGGAACTGCTGGTCAGGGGACTTTGTCGCCCTGTGCACTAAAAG
GGCCAGATTTTCAGCAGCCAAGGACATCCATACCCAAGTGAATGTGATGGGACTTAAAAGAAGTGAACTGAGACAATTCACTCTGGCTGT
TTGAACAGCAGCGTTTCATAGGAAGAGAAAAAAAGATCAATCTTGTATTTTCTGACCACATAAAGGCTTCTTCTCTTTGTAATAAAGTAG

>44591_44591_2_LGR5-CNOT2_LGR5_chr12_71928966_ENST00000266674_CNOT2_chr12_70747608_ENST00000418359_length(amino acids)=195AA_BP=
MSPLQPGLLRRPAWRQPAPLSPPRFSSPPTPWGQERGVWRCRRPLSCRSPRSGARRATARSSPVLLSARVRLVAPYFGHHGHLPARCAPV
LACAAAAGDRGQLSQVWCVAEGLPHTLSLRARRQDVAQGGLLRPGALGAAFQPQRLHLLPRPQYEQHQSAAPESPAQSPLPGGVTSCGKR

--------------------------------------------------------------
>44591_44591_3_LGR5-CNOT2_LGR5_chr12_71928966_ENST00000266674_CNOT2_chr12_70747609_ENST00000229195_length(transcript)=1904nt_BP=739nt
AAAAAACGAGCGTGCAAGCAGAGATGCTGCTCCACACCGCTCAGGCCGCGAGCAGCAGCAAGGCGCACCGCCACTGTCGCCGCTGCAGCC
AGGGCTGCTCCGAAGGCCGGCGTGGCGGCAACCGGCACCTCTGTCCCCGCCGCGCTTCTCCTCGCCGCCCACGCCGTGGGGTCAGGAACG
CGGCGTCTGGCGCTGCAGACGCCCGCTGAGTTGCAGAAGCCCACGGAGCGGCGCCCGGCGCGCCACGGCCCGTAGCAGTCCGGTGCTGCT
CTCCGCCCGCGTCCGGCTCGTGGCCCCCTACTTCGGGCACCATGGACACCTCCCGGCTCGGTGTGCTCCTGTCCTTGCCTGTGCTGCTGC
AGCTGGCGACCGGGGGCAGCTCTCCCAGGTCTGGTGTGTTGCTGAGGGGCTGCCCCACACACTGTCATTGCGAGCCCGACGGCAGGATGT
TGCTCAGGGTGGACTGCTCCGACCTGGGGCTCTCGGAGCTGCCTTCCAACCTCAGCGTCTTCACCTCCTACCTAGACCTCAGTATGAACA
ACATCAGTCAGCTGCTCCCGAATCCCCTGCCCAGTCTCCGCTTCCTGGAGGAGTTACGTCTTGCGGGAAACGCTCTGACATACATTCCCA
AGGGAGCATTCACTGGCCTTTACAGTCTTAAAGTTCTTATGCTGCAGAATAATCAGCTAAGACACGTACCCACAGAAGCTCTGCAGAATT
TGCGAAGCCTTCAATCCCTGAGTTCCATCTGGAATATGACAAATTAGAAGAACGGCCTCACCTGCCATCCACCTTCAACTACAACCCTGC
TCAGCAAGCCTTCTAAAAAAAAAAAAAAAAAAAAAAAAAGACTTCCCTTTTCTTGGGGTATGGCTGTCTCAGCACAATACTCAACATAAC
TGCAGAACTGATGTGGCTCAGGCACCCTGGTTTTAATTCCTTGAGGATCTGGCAATTGGCTTACGCAAAAGGTCACCATTTGAGGTCCTG
CCTTACTAATTATGTGCTGCCCAACAACTAAATTTGTAATTTGTTTTTCTCTAGTTTGAGCAGGGTCTGAATTTTTTCATTTATTTCCTT
TTTTGCCAGCAGACAGACTTGAGTCTGTAAAGACAAGCAAATACACTGACAGAAGTTTACCATAGTTTCTAAAATGTAAAAAAGAAAACC
CCCAAAAGACTCAAGAAAATTAGACCACAAATTTTGCATTGTTCATTGTAGCACTATTGGTAATAAAATAACAAATGTTTGTGCATTTTT
ATGTGAAGATCCTTCTCGTATTTCATTTGGAAAGATGAGCAAGAGGTCTGCTTCCTTCATTTTACTTCCCCTTCTGTTTTTGAAAGGCAG
TTTCGCCAAGCTTAATGCAAGAATATCTGACTGTTTAGAAGAAAGATATTGCCACAATCTCTGGATGGTTTTCCAGGGTTGTGTTATTAC
TGAGCTTCATCTTTCCAGAATGAGCAAAACACTGTCCAGTCTTTGTTACGATTTTGTAATAAATGTGTACATTTTTTTTAAATTTTTGGA
CATCACATGAATAAAGGTATGTATGTACGAATGTGTATATATTATATATATGACATCTATTTTGGAAAATGTTTGCCCTGCTGTACCTCA
TTTTTAGGAGGTGTGCATGGATGCAATATATGAAAATGGGACATTCTGGAACTGCTGGTCAGGGGACTTTGTCGCCCTGTGCACTAAAAG
GGCCAGATTTTCAGCAGCCAAGGACATCCATACCCAAGTGAATGTGATGGGACTTAAAAGAAGTGAACTGAGACAATTCACTCTGGCTGT
TTGAACAGCAGCGTTTCATAGGAAGAGAAAAAAAGATCAATCTTGTATTTTCTGACCACATAAAGGCTTCTTCTCTTTGTAATAAAGTAG

>44591_44591_3_LGR5-CNOT2_LGR5_chr12_71928966_ENST00000266674_CNOT2_chr12_70747609_ENST00000229195_length(amino acids)=195AA_BP=
MSPLQPGLLRRPAWRQPAPLSPPRFSSPPTPWGQERGVWRCRRPLSCRSPRSGARRATARSSPVLLSARVRLVAPYFGHHGHLPARCAPV
LACAAAAGDRGQLSQVWCVAEGLPHTLSLRARRQDVAQGGLLRPGALGAAFQPQRLHLLPRPQYEQHQSAAPESPAQSPLPGGVTSCGKR

--------------------------------------------------------------
>44591_44591_4_LGR5-CNOT2_LGR5_chr12_71928966_ENST00000266674_CNOT2_chr12_70747609_ENST00000418359_length(transcript)=1904nt_BP=739nt
AAAAAACGAGCGTGCAAGCAGAGATGCTGCTCCACACCGCTCAGGCCGCGAGCAGCAGCAAGGCGCACCGCCACTGTCGCCGCTGCAGCC
AGGGCTGCTCCGAAGGCCGGCGTGGCGGCAACCGGCACCTCTGTCCCCGCCGCGCTTCTCCTCGCCGCCCACGCCGTGGGGTCAGGAACG
CGGCGTCTGGCGCTGCAGACGCCCGCTGAGTTGCAGAAGCCCACGGAGCGGCGCCCGGCGCGCCACGGCCCGTAGCAGTCCGGTGCTGCT
CTCCGCCCGCGTCCGGCTCGTGGCCCCCTACTTCGGGCACCATGGACACCTCCCGGCTCGGTGTGCTCCTGTCCTTGCCTGTGCTGCTGC
AGCTGGCGACCGGGGGCAGCTCTCCCAGGTCTGGTGTGTTGCTGAGGGGCTGCCCCACACACTGTCATTGCGAGCCCGACGGCAGGATGT
TGCTCAGGGTGGACTGCTCCGACCTGGGGCTCTCGGAGCTGCCTTCCAACCTCAGCGTCTTCACCTCCTACCTAGACCTCAGTATGAACA
ACATCAGTCAGCTGCTCCCGAATCCCCTGCCCAGTCTCCGCTTCCTGGAGGAGTTACGTCTTGCGGGAAACGCTCTGACATACATTCCCA
AGGGAGCATTCACTGGCCTTTACAGTCTTAAAGTTCTTATGCTGCAGAATAATCAGCTAAGACACGTACCCACAGAAGCTCTGCAGAATT
TGCGAAGCCTTCAATCCCTGAGTTCCATCTGGAATATGACAAATTAGAAGAACGGCCTCACCTGCCATCCACCTTCAACTACAACCCTGC
TCAGCAAGCCTTCTAAAAAAAAAAAAAAAAAAAAAAAAAGACTTCCCTTTTCTTGGGGTATGGCTGTCTCAGCACAATACTCAACATAAC
TGCAGAACTGATGTGGCTCAGGCACCCTGGTTTTAATTCCTTGAGGATCTGGCAATTGGCTTACGCAAAAGGTCACCATTTGAGGTCCTG
CCTTACTAATTATGTGCTGCCCAACAACTAAATTTGTAATTTGTTTTTCTCTAGTTTGAGCAGGGTCTGAATTTTTTCATTTATTTCCTT
TTTTGCCAGCAGACAGACTTGAGTCTGTAAAGACAAGCAAATACACTGACAGAAGTTTACCATAGTTTCTAAAATGTAAAAAAGAAAACC
CCCAAAAGACTCAAGAAAATTAGACCACAAATTTTGCATTGTTCATTGTAGCACTATTGGTAATAAAATAACAAATGTTTGTGCATTTTT
ATGTGAAGATCCTTCTCGTATTTCATTTGGAAAGATGAGCAAGAGGTCTGCTTCCTTCATTTTACTTCCCCTTCTGTTTTTGAAAGGCAG
TTTCGCCAAGCTTAATGCAAGAATATCTGACTGTTTAGAAGAAAGATATTGCCACAATCTCTGGATGGTTTTCCAGGGTTGTGTTATTAC
TGAGCTTCATCTTTCCAGAATGAGCAAAACACTGTCCAGTCTTTGTTACGATTTTGTAATAAATGTGTACATTTTTTTTAAATTTTTGGA
CATCACATGAATAAAGGTATGTATGTACGAATGTGTATATATTATATATATGACATCTATTTTGGAAAATGTTTGCCCTGCTGTACCTCA
TTTTTAGGAGGTGTGCATGGATGCAATATATGAAAATGGGACATTCTGGAACTGCTGGTCAGGGGACTTTGTCGCCCTGTGCACTAAAAG
GGCCAGATTTTCAGCAGCCAAGGACATCCATACCCAAGTGAATGTGATGGGACTTAAAAGAAGTGAACTGAGACAATTCACTCTGGCTGT
TTGAACAGCAGCGTTTCATAGGAAGAGAAAAAAAGATCAATCTTGTATTTTCTGACCACATAAAGGCTTCTTCTCTTTGTAATAAAGTAG

>44591_44591_4_LGR5-CNOT2_LGR5_chr12_71928966_ENST00000266674_CNOT2_chr12_70747609_ENST00000418359_length(amino acids)=195AA_BP=
MSPLQPGLLRRPAWRQPAPLSPPRFSSPPTPWGQERGVWRCRRPLSCRSPRSGARRATARSSPVLLSARVRLVAPYFGHHGHLPARCAPV
LACAAAAGDRGQLSQVWCVAEGLPHTLSLRARRQDVAQGGLLRPGALGAAFQPQRLHLLPRPQYEQHQSAAPESPAQSPLPGGVTSCGKR

--------------------------------------------------------------
>44591_44591_5_LGR5-CNOT2_LGR5_chr12_71928966_ENST00000536515_CNOT2_chr12_70747608_ENST00000229195_length(transcript)=1641nt_BP=476nt
TGCTGCTCTCCGCCCGCGTCCGGCTCGTGGCCCCCTACTTCGGGCACCATGGACACCTCCCGGCTCGGTGTGCTCCTGTCCTTGCCTGTG
CTGCTGCAGCTGGCGACCGGGGGCAGCTCTCCCAGGTCTGGTGTGTTGCTGAGGGGCTGCCCCACACACTGTCATTGCGAGCCCGACGGC
AGGATGTTGCTCAGGGTGGACTGCTCCGACCTGGGGCTCTCGGAGCTGCCTTCCAACCTCAGCGTCTTCACCTCCTACCTAGACCTCAGT
ATGAACAACATCAGTCAGCTGCTCCCGAATCCCCTGCCCAGTCTCCGCTTCCTGGAGGAGTTACGTCTTGCGGGAAACGCTCTGACATAC
ATTCCCAAGGGAGCATTCACTGGCCTTTACAGTCTTAAAGTTCTTATGCTGCAGAATAATCAGCTAAGACACGTACCCACAGAAGCTCTG
CAGAATTTGCGAAGCCTTCAATCCCTGAGTTCCATCTGGAATATGACAAATTAGAAGAACGGCCTCACCTGCCATCCACCTTCAACTACA
ACCCTGCTCAGCAAGCCTTCTAAAAAAAAAAAAAAAAAAAAAAAAAGACTTCCCTTTTCTTGGGGTATGGCTGTCTCAGCACAATACTCA
ACATAACTGCAGAACTGATGTGGCTCAGGCACCCTGGTTTTAATTCCTTGAGGATCTGGCAATTGGCTTACGCAAAAGGTCACCATTTGA
GGTCCTGCCTTACTAATTATGTGCTGCCCAACAACTAAATTTGTAATTTGTTTTTCTCTAGTTTGAGCAGGGTCTGAATTTTTTCATTTA
TTTCCTTTTTTGCCAGCAGACAGACTTGAGTCTGTAAAGACAAGCAAATACACTGACAGAAGTTTACCATAGTTTCTAAAATGTAAAAAA
GAAAACCCCCAAAAGACTCAAGAAAATTAGACCACAAATTTTGCATTGTTCATTGTAGCACTATTGGTAATAAAATAACAAATGTTTGTG
CATTTTTATGTGAAGATCCTTCTCGTATTTCATTTGGAAAGATGAGCAAGAGGTCTGCTTCCTTCATTTTACTTCCCCTTCTGTTTTTGA
AAGGCAGTTTCGCCAAGCTTAATGCAAGAATATCTGACTGTTTAGAAGAAAGATATTGCCACAATCTCTGGATGGTTTTCCAGGGTTGTG
TTATTACTGAGCTTCATCTTTCCAGAATGAGCAAAACACTGTCCAGTCTTTGTTACGATTTTGTAATAAATGTGTACATTTTTTTTAAAT
TTTTGGACATCACATGAATAAAGGTATGTATGTACGAATGTGTATATATTATATATATGACATCTATTTTGGAAAATGTTTGCCCTGCTG
TACCTCATTTTTAGGAGGTGTGCATGGATGCAATATATGAAAATGGGACATTCTGGAACTGCTGGTCAGGGGACTTTGTCGCCCTGTGCA
CTAAAAGGGCCAGATTTTCAGCAGCCAAGGACATCCATACCCAAGTGAATGTGATGGGACTTAAAAGAAGTGAACTGAGACAATTCACTC
TGGCTGTTTGAACAGCAGCGTTTCATAGGAAGAGAAAAAAAGATCAATCTTGTATTTTCTGACCACATAAAGGCTTCTTCTCTTTGTAAT

>44591_44591_5_LGR5-CNOT2_LGR5_chr12_71928966_ENST00000536515_CNOT2_chr12_70747608_ENST00000229195_length(amino acids)=151AA_BP=
MDTSRLGVLLSLPVLLQLATGGSSPRSGVLLRGCPTHCHCEPDGRMLLRVDCSDLGLSELPSNLSVFTSYLDLSMNNISQLLPNPLPSLR

--------------------------------------------------------------
>44591_44591_6_LGR5-CNOT2_LGR5_chr12_71928966_ENST00000536515_CNOT2_chr12_70747608_ENST00000418359_length(transcript)=1641nt_BP=476nt
TGCTGCTCTCCGCCCGCGTCCGGCTCGTGGCCCCCTACTTCGGGCACCATGGACACCTCCCGGCTCGGTGTGCTCCTGTCCTTGCCTGTG
CTGCTGCAGCTGGCGACCGGGGGCAGCTCTCCCAGGTCTGGTGTGTTGCTGAGGGGCTGCCCCACACACTGTCATTGCGAGCCCGACGGC
AGGATGTTGCTCAGGGTGGACTGCTCCGACCTGGGGCTCTCGGAGCTGCCTTCCAACCTCAGCGTCTTCACCTCCTACCTAGACCTCAGT
ATGAACAACATCAGTCAGCTGCTCCCGAATCCCCTGCCCAGTCTCCGCTTCCTGGAGGAGTTACGTCTTGCGGGAAACGCTCTGACATAC
ATTCCCAAGGGAGCATTCACTGGCCTTTACAGTCTTAAAGTTCTTATGCTGCAGAATAATCAGCTAAGACACGTACCCACAGAAGCTCTG
CAGAATTTGCGAAGCCTTCAATCCCTGAGTTCCATCTGGAATATGACAAATTAGAAGAACGGCCTCACCTGCCATCCACCTTCAACTACA
ACCCTGCTCAGCAAGCCTTCTAAAAAAAAAAAAAAAAAAAAAAAAAGACTTCCCTTTTCTTGGGGTATGGCTGTCTCAGCACAATACTCA
ACATAACTGCAGAACTGATGTGGCTCAGGCACCCTGGTTTTAATTCCTTGAGGATCTGGCAATTGGCTTACGCAAAAGGTCACCATTTGA
GGTCCTGCCTTACTAATTATGTGCTGCCCAACAACTAAATTTGTAATTTGTTTTTCTCTAGTTTGAGCAGGGTCTGAATTTTTTCATTTA
TTTCCTTTTTTGCCAGCAGACAGACTTGAGTCTGTAAAGACAAGCAAATACACTGACAGAAGTTTACCATAGTTTCTAAAATGTAAAAAA
GAAAACCCCCAAAAGACTCAAGAAAATTAGACCACAAATTTTGCATTGTTCATTGTAGCACTATTGGTAATAAAATAACAAATGTTTGTG
CATTTTTATGTGAAGATCCTTCTCGTATTTCATTTGGAAAGATGAGCAAGAGGTCTGCTTCCTTCATTTTACTTCCCCTTCTGTTTTTGA
AAGGCAGTTTCGCCAAGCTTAATGCAAGAATATCTGACTGTTTAGAAGAAAGATATTGCCACAATCTCTGGATGGTTTTCCAGGGTTGTG
TTATTACTGAGCTTCATCTTTCCAGAATGAGCAAAACACTGTCCAGTCTTTGTTACGATTTTGTAATAAATGTGTACATTTTTTTTAAAT
TTTTGGACATCACATGAATAAAGGTATGTATGTACGAATGTGTATATATTATATATATGACATCTATTTTGGAAAATGTTTGCCCTGCTG
TACCTCATTTTTAGGAGGTGTGCATGGATGCAATATATGAAAATGGGACATTCTGGAACTGCTGGTCAGGGGACTTTGTCGCCCTGTGCA
CTAAAAGGGCCAGATTTTCAGCAGCCAAGGACATCCATACCCAAGTGAATGTGATGGGACTTAAAAGAAGTGAACTGAGACAATTCACTC
TGGCTGTTTGAACAGCAGCGTTTCATAGGAAGAGAAAAAAAGATCAATCTTGTATTTTCTGACCACATAAAGGCTTCTTCTCTTTGTAAT

>44591_44591_6_LGR5-CNOT2_LGR5_chr12_71928966_ENST00000536515_CNOT2_chr12_70747608_ENST00000418359_length(amino acids)=151AA_BP=
MDTSRLGVLLSLPVLLQLATGGSSPRSGVLLRGCPTHCHCEPDGRMLLRVDCSDLGLSELPSNLSVFTSYLDLSMNNISQLLPNPLPSLR

--------------------------------------------------------------
>44591_44591_7_LGR5-CNOT2_LGR5_chr12_71928966_ENST00000536515_CNOT2_chr12_70747609_ENST00000229195_length(transcript)=1641nt_BP=476nt
TGCTGCTCTCCGCCCGCGTCCGGCTCGTGGCCCCCTACTTCGGGCACCATGGACACCTCCCGGCTCGGTGTGCTCCTGTCCTTGCCTGTG
CTGCTGCAGCTGGCGACCGGGGGCAGCTCTCCCAGGTCTGGTGTGTTGCTGAGGGGCTGCCCCACACACTGTCATTGCGAGCCCGACGGC
AGGATGTTGCTCAGGGTGGACTGCTCCGACCTGGGGCTCTCGGAGCTGCCTTCCAACCTCAGCGTCTTCACCTCCTACCTAGACCTCAGT
ATGAACAACATCAGTCAGCTGCTCCCGAATCCCCTGCCCAGTCTCCGCTTCCTGGAGGAGTTACGTCTTGCGGGAAACGCTCTGACATAC
ATTCCCAAGGGAGCATTCACTGGCCTTTACAGTCTTAAAGTTCTTATGCTGCAGAATAATCAGCTAAGACACGTACCCACAGAAGCTCTG
CAGAATTTGCGAAGCCTTCAATCCCTGAGTTCCATCTGGAATATGACAAATTAGAAGAACGGCCTCACCTGCCATCCACCTTCAACTACA
ACCCTGCTCAGCAAGCCTTCTAAAAAAAAAAAAAAAAAAAAAAAAAGACTTCCCTTTTCTTGGGGTATGGCTGTCTCAGCACAATACTCA
ACATAACTGCAGAACTGATGTGGCTCAGGCACCCTGGTTTTAATTCCTTGAGGATCTGGCAATTGGCTTACGCAAAAGGTCACCATTTGA
GGTCCTGCCTTACTAATTATGTGCTGCCCAACAACTAAATTTGTAATTTGTTTTTCTCTAGTTTGAGCAGGGTCTGAATTTTTTCATTTA
TTTCCTTTTTTGCCAGCAGACAGACTTGAGTCTGTAAAGACAAGCAAATACACTGACAGAAGTTTACCATAGTTTCTAAAATGTAAAAAA
GAAAACCCCCAAAAGACTCAAGAAAATTAGACCACAAATTTTGCATTGTTCATTGTAGCACTATTGGTAATAAAATAACAAATGTTTGTG
CATTTTTATGTGAAGATCCTTCTCGTATTTCATTTGGAAAGATGAGCAAGAGGTCTGCTTCCTTCATTTTACTTCCCCTTCTGTTTTTGA
AAGGCAGTTTCGCCAAGCTTAATGCAAGAATATCTGACTGTTTAGAAGAAAGATATTGCCACAATCTCTGGATGGTTTTCCAGGGTTGTG
TTATTACTGAGCTTCATCTTTCCAGAATGAGCAAAACACTGTCCAGTCTTTGTTACGATTTTGTAATAAATGTGTACATTTTTTTTAAAT
TTTTGGACATCACATGAATAAAGGTATGTATGTACGAATGTGTATATATTATATATATGACATCTATTTTGGAAAATGTTTGCCCTGCTG
TACCTCATTTTTAGGAGGTGTGCATGGATGCAATATATGAAAATGGGACATTCTGGAACTGCTGGTCAGGGGACTTTGTCGCCCTGTGCA
CTAAAAGGGCCAGATTTTCAGCAGCCAAGGACATCCATACCCAAGTGAATGTGATGGGACTTAAAAGAAGTGAACTGAGACAATTCACTC
TGGCTGTTTGAACAGCAGCGTTTCATAGGAAGAGAAAAAAAGATCAATCTTGTATTTTCTGACCACATAAAGGCTTCTTCTCTTTGTAAT

>44591_44591_7_LGR5-CNOT2_LGR5_chr12_71928966_ENST00000536515_CNOT2_chr12_70747609_ENST00000229195_length(amino acids)=151AA_BP=
MDTSRLGVLLSLPVLLQLATGGSSPRSGVLLRGCPTHCHCEPDGRMLLRVDCSDLGLSELPSNLSVFTSYLDLSMNNISQLLPNPLPSLR

--------------------------------------------------------------
>44591_44591_8_LGR5-CNOT2_LGR5_chr12_71928966_ENST00000536515_CNOT2_chr12_70747609_ENST00000418359_length(transcript)=1641nt_BP=476nt
TGCTGCTCTCCGCCCGCGTCCGGCTCGTGGCCCCCTACTTCGGGCACCATGGACACCTCCCGGCTCGGTGTGCTCCTGTCCTTGCCTGTG
CTGCTGCAGCTGGCGACCGGGGGCAGCTCTCCCAGGTCTGGTGTGTTGCTGAGGGGCTGCCCCACACACTGTCATTGCGAGCCCGACGGC
AGGATGTTGCTCAGGGTGGACTGCTCCGACCTGGGGCTCTCGGAGCTGCCTTCCAACCTCAGCGTCTTCACCTCCTACCTAGACCTCAGT
ATGAACAACATCAGTCAGCTGCTCCCGAATCCCCTGCCCAGTCTCCGCTTCCTGGAGGAGTTACGTCTTGCGGGAAACGCTCTGACATAC
ATTCCCAAGGGAGCATTCACTGGCCTTTACAGTCTTAAAGTTCTTATGCTGCAGAATAATCAGCTAAGACACGTACCCACAGAAGCTCTG
CAGAATTTGCGAAGCCTTCAATCCCTGAGTTCCATCTGGAATATGACAAATTAGAAGAACGGCCTCACCTGCCATCCACCTTCAACTACA
ACCCTGCTCAGCAAGCCTTCTAAAAAAAAAAAAAAAAAAAAAAAAAGACTTCCCTTTTCTTGGGGTATGGCTGTCTCAGCACAATACTCA
ACATAACTGCAGAACTGATGTGGCTCAGGCACCCTGGTTTTAATTCCTTGAGGATCTGGCAATTGGCTTACGCAAAAGGTCACCATTTGA
GGTCCTGCCTTACTAATTATGTGCTGCCCAACAACTAAATTTGTAATTTGTTTTTCTCTAGTTTGAGCAGGGTCTGAATTTTTTCATTTA
TTTCCTTTTTTGCCAGCAGACAGACTTGAGTCTGTAAAGACAAGCAAATACACTGACAGAAGTTTACCATAGTTTCTAAAATGTAAAAAA
GAAAACCCCCAAAAGACTCAAGAAAATTAGACCACAAATTTTGCATTGTTCATTGTAGCACTATTGGTAATAAAATAACAAATGTTTGTG
CATTTTTATGTGAAGATCCTTCTCGTATTTCATTTGGAAAGATGAGCAAGAGGTCTGCTTCCTTCATTTTACTTCCCCTTCTGTTTTTGA
AAGGCAGTTTCGCCAAGCTTAATGCAAGAATATCTGACTGTTTAGAAGAAAGATATTGCCACAATCTCTGGATGGTTTTCCAGGGTTGTG
TTATTACTGAGCTTCATCTTTCCAGAATGAGCAAAACACTGTCCAGTCTTTGTTACGATTTTGTAATAAATGTGTACATTTTTTTTAAAT
TTTTGGACATCACATGAATAAAGGTATGTATGTACGAATGTGTATATATTATATATATGACATCTATTTTGGAAAATGTTTGCCCTGCTG
TACCTCATTTTTAGGAGGTGTGCATGGATGCAATATATGAAAATGGGACATTCTGGAACTGCTGGTCAGGGGACTTTGTCGCCCTGTGCA
CTAAAAGGGCCAGATTTTCAGCAGCCAAGGACATCCATACCCAAGTGAATGTGATGGGACTTAAAAGAAGTGAACTGAGACAATTCACTC
TGGCTGTTTGAACAGCAGCGTTTCATAGGAAGAGAAAAAAAGATCAATCTTGTATTTTCTGACCACATAAAGGCTTCTTCTCTTTGTAAT

>44591_44591_8_LGR5-CNOT2_LGR5_chr12_71928966_ENST00000536515_CNOT2_chr12_70747609_ENST00000418359_length(amino acids)=151AA_BP=
MDTSRLGVLLSLPVLLQLATGGSSPRSGVLLRGCPTHCHCEPDGRMLLRVDCSDLGLSELPSNLSVFTSYLDLSMNNISQLLPNPLPSLR

--------------------------------------------------------------
>44591_44591_9_LGR5-CNOT2_LGR5_chr12_71928966_ENST00000540815_CNOT2_chr12_70747608_ENST00000229195_length(transcript)=1639nt_BP=474nt
CTGCTCTCCGCCCGCGTCCGGCTCGTGGCCCCCTACTTCGGGCACCATGGACACCTCCCGGCTCGGTGTGCTCCTGTCCTTGCCTGTGCT
GCTGCAGCTGGCGACCGGGGGCAGCTCTCCCAGGTCTGGTGTGTTGCTGAGGGGCTGCCCCACACACTGTCATTGCGAGCCCGACGGCAG
GATGTTGCTCAGGGTGGACTGCTCCGACCTGGGGCTCTCGGAGCTGCCTTCCAACCTCAGCGTCTTCACCTCCTACCTAGACCTCAGTAT
GAACAACATCAGTCAGCTGCTCCCGAATCCCCTGCCCAGTCTCCGCTTCCTGGAGGAGTTACGTCTTGCGGGAAACGCTCTGACATACAT
TCCCAAGGGAGCATTCACTGGCCTTTACAGTCTTAAAGTTCTTATGCTGCAGAATAATCAGCTAAGACACGTACCCACAGAAGCTCTGCA
GAATTTGCGAAGCCTTCAATCCCTGAGTTCCATCTGGAATATGACAAATTAGAAGAACGGCCTCACCTGCCATCCACCTTCAACTACAAC
CCTGCTCAGCAAGCCTTCTAAAAAAAAAAAAAAAAAAAAAAAAAGACTTCCCTTTTCTTGGGGTATGGCTGTCTCAGCACAATACTCAAC
ATAACTGCAGAACTGATGTGGCTCAGGCACCCTGGTTTTAATTCCTTGAGGATCTGGCAATTGGCTTACGCAAAAGGTCACCATTTGAGG
TCCTGCCTTACTAATTATGTGCTGCCCAACAACTAAATTTGTAATTTGTTTTTCTCTAGTTTGAGCAGGGTCTGAATTTTTTCATTTATT
TCCTTTTTTGCCAGCAGACAGACTTGAGTCTGTAAAGACAAGCAAATACACTGACAGAAGTTTACCATAGTTTCTAAAATGTAAAAAAGA
AAACCCCCAAAAGACTCAAGAAAATTAGACCACAAATTTTGCATTGTTCATTGTAGCACTATTGGTAATAAAATAACAAATGTTTGTGCA
TTTTTATGTGAAGATCCTTCTCGTATTTCATTTGGAAAGATGAGCAAGAGGTCTGCTTCCTTCATTTTACTTCCCCTTCTGTTTTTGAAA
GGCAGTTTCGCCAAGCTTAATGCAAGAATATCTGACTGTTTAGAAGAAAGATATTGCCACAATCTCTGGATGGTTTTCCAGGGTTGTGTT
ATTACTGAGCTTCATCTTTCCAGAATGAGCAAAACACTGTCCAGTCTTTGTTACGATTTTGTAATAAATGTGTACATTTTTTTTAAATTT
TTGGACATCACATGAATAAAGGTATGTATGTACGAATGTGTATATATTATATATATGACATCTATTTTGGAAAATGTTTGCCCTGCTGTA
CCTCATTTTTAGGAGGTGTGCATGGATGCAATATATGAAAATGGGACATTCTGGAACTGCTGGTCAGGGGACTTTGTCGCCCTGTGCACT
AAAAGGGCCAGATTTTCAGCAGCCAAGGACATCCATACCCAAGTGAATGTGATGGGACTTAAAAGAAGTGAACTGAGACAATTCACTCTG
GCTGTTTGAACAGCAGCGTTTCATAGGAAGAGAAAAAAAGATCAATCTTGTATTTTCTGACCACATAAAGGCTTCTTCTCTTTGTAATAA

>44591_44591_9_LGR5-CNOT2_LGR5_chr12_71928966_ENST00000540815_CNOT2_chr12_70747608_ENST00000229195_length(amino acids)=151AA_BP=
MDTSRLGVLLSLPVLLQLATGGSSPRSGVLLRGCPTHCHCEPDGRMLLRVDCSDLGLSELPSNLSVFTSYLDLSMNNISQLLPNPLPSLR

--------------------------------------------------------------
>44591_44591_10_LGR5-CNOT2_LGR5_chr12_71928966_ENST00000540815_CNOT2_chr12_70747608_ENST00000418359_length(transcript)=1639nt_BP=474nt
CTGCTCTCCGCCCGCGTCCGGCTCGTGGCCCCCTACTTCGGGCACCATGGACACCTCCCGGCTCGGTGTGCTCCTGTCCTTGCCTGTGCT
GCTGCAGCTGGCGACCGGGGGCAGCTCTCCCAGGTCTGGTGTGTTGCTGAGGGGCTGCCCCACACACTGTCATTGCGAGCCCGACGGCAG
GATGTTGCTCAGGGTGGACTGCTCCGACCTGGGGCTCTCGGAGCTGCCTTCCAACCTCAGCGTCTTCACCTCCTACCTAGACCTCAGTAT
GAACAACATCAGTCAGCTGCTCCCGAATCCCCTGCCCAGTCTCCGCTTCCTGGAGGAGTTACGTCTTGCGGGAAACGCTCTGACATACAT
TCCCAAGGGAGCATTCACTGGCCTTTACAGTCTTAAAGTTCTTATGCTGCAGAATAATCAGCTAAGACACGTACCCACAGAAGCTCTGCA
GAATTTGCGAAGCCTTCAATCCCTGAGTTCCATCTGGAATATGACAAATTAGAAGAACGGCCTCACCTGCCATCCACCTTCAACTACAAC
CCTGCTCAGCAAGCCTTCTAAAAAAAAAAAAAAAAAAAAAAAAAGACTTCCCTTTTCTTGGGGTATGGCTGTCTCAGCACAATACTCAAC
ATAACTGCAGAACTGATGTGGCTCAGGCACCCTGGTTTTAATTCCTTGAGGATCTGGCAATTGGCTTACGCAAAAGGTCACCATTTGAGG
TCCTGCCTTACTAATTATGTGCTGCCCAACAACTAAATTTGTAATTTGTTTTTCTCTAGTTTGAGCAGGGTCTGAATTTTTTCATTTATT
TCCTTTTTTGCCAGCAGACAGACTTGAGTCTGTAAAGACAAGCAAATACACTGACAGAAGTTTACCATAGTTTCTAAAATGTAAAAAAGA
AAACCCCCAAAAGACTCAAGAAAATTAGACCACAAATTTTGCATTGTTCATTGTAGCACTATTGGTAATAAAATAACAAATGTTTGTGCA
TTTTTATGTGAAGATCCTTCTCGTATTTCATTTGGAAAGATGAGCAAGAGGTCTGCTTCCTTCATTTTACTTCCCCTTCTGTTTTTGAAA
GGCAGTTTCGCCAAGCTTAATGCAAGAATATCTGACTGTTTAGAAGAAAGATATTGCCACAATCTCTGGATGGTTTTCCAGGGTTGTGTT
ATTACTGAGCTTCATCTTTCCAGAATGAGCAAAACACTGTCCAGTCTTTGTTACGATTTTGTAATAAATGTGTACATTTTTTTTAAATTT
TTGGACATCACATGAATAAAGGTATGTATGTACGAATGTGTATATATTATATATATGACATCTATTTTGGAAAATGTTTGCCCTGCTGTA
CCTCATTTTTAGGAGGTGTGCATGGATGCAATATATGAAAATGGGACATTCTGGAACTGCTGGTCAGGGGACTTTGTCGCCCTGTGCACT
AAAAGGGCCAGATTTTCAGCAGCCAAGGACATCCATACCCAAGTGAATGTGATGGGACTTAAAAGAAGTGAACTGAGACAATTCACTCTG
GCTGTTTGAACAGCAGCGTTTCATAGGAAGAGAAAAAAAGATCAATCTTGTATTTTCTGACCACATAAAGGCTTCTTCTCTTTGTAATAA

>44591_44591_10_LGR5-CNOT2_LGR5_chr12_71928966_ENST00000540815_CNOT2_chr12_70747608_ENST00000418359_length(amino acids)=151AA_BP=
MDTSRLGVLLSLPVLLQLATGGSSPRSGVLLRGCPTHCHCEPDGRMLLRVDCSDLGLSELPSNLSVFTSYLDLSMNNISQLLPNPLPSLR

--------------------------------------------------------------
>44591_44591_11_LGR5-CNOT2_LGR5_chr12_71928966_ENST00000540815_CNOT2_chr12_70747609_ENST00000229195_length(transcript)=1639nt_BP=474nt
CTGCTCTCCGCCCGCGTCCGGCTCGTGGCCCCCTACTTCGGGCACCATGGACACCTCCCGGCTCGGTGTGCTCCTGTCCTTGCCTGTGCT
GCTGCAGCTGGCGACCGGGGGCAGCTCTCCCAGGTCTGGTGTGTTGCTGAGGGGCTGCCCCACACACTGTCATTGCGAGCCCGACGGCAG
GATGTTGCTCAGGGTGGACTGCTCCGACCTGGGGCTCTCGGAGCTGCCTTCCAACCTCAGCGTCTTCACCTCCTACCTAGACCTCAGTAT
GAACAACATCAGTCAGCTGCTCCCGAATCCCCTGCCCAGTCTCCGCTTCCTGGAGGAGTTACGTCTTGCGGGAAACGCTCTGACATACAT
TCCCAAGGGAGCATTCACTGGCCTTTACAGTCTTAAAGTTCTTATGCTGCAGAATAATCAGCTAAGACACGTACCCACAGAAGCTCTGCA
GAATTTGCGAAGCCTTCAATCCCTGAGTTCCATCTGGAATATGACAAATTAGAAGAACGGCCTCACCTGCCATCCACCTTCAACTACAAC
CCTGCTCAGCAAGCCTTCTAAAAAAAAAAAAAAAAAAAAAAAAAGACTTCCCTTTTCTTGGGGTATGGCTGTCTCAGCACAATACTCAAC
ATAACTGCAGAACTGATGTGGCTCAGGCACCCTGGTTTTAATTCCTTGAGGATCTGGCAATTGGCTTACGCAAAAGGTCACCATTTGAGG
TCCTGCCTTACTAATTATGTGCTGCCCAACAACTAAATTTGTAATTTGTTTTTCTCTAGTTTGAGCAGGGTCTGAATTTTTTCATTTATT
TCCTTTTTTGCCAGCAGACAGACTTGAGTCTGTAAAGACAAGCAAATACACTGACAGAAGTTTACCATAGTTTCTAAAATGTAAAAAAGA
AAACCCCCAAAAGACTCAAGAAAATTAGACCACAAATTTTGCATTGTTCATTGTAGCACTATTGGTAATAAAATAACAAATGTTTGTGCA
TTTTTATGTGAAGATCCTTCTCGTATTTCATTTGGAAAGATGAGCAAGAGGTCTGCTTCCTTCATTTTACTTCCCCTTCTGTTTTTGAAA
GGCAGTTTCGCCAAGCTTAATGCAAGAATATCTGACTGTTTAGAAGAAAGATATTGCCACAATCTCTGGATGGTTTTCCAGGGTTGTGTT
ATTACTGAGCTTCATCTTTCCAGAATGAGCAAAACACTGTCCAGTCTTTGTTACGATTTTGTAATAAATGTGTACATTTTTTTTAAATTT
TTGGACATCACATGAATAAAGGTATGTATGTACGAATGTGTATATATTATATATATGACATCTATTTTGGAAAATGTTTGCCCTGCTGTA
CCTCATTTTTAGGAGGTGTGCATGGATGCAATATATGAAAATGGGACATTCTGGAACTGCTGGTCAGGGGACTTTGTCGCCCTGTGCACT
AAAAGGGCCAGATTTTCAGCAGCCAAGGACATCCATACCCAAGTGAATGTGATGGGACTTAAAAGAAGTGAACTGAGACAATTCACTCTG
GCTGTTTGAACAGCAGCGTTTCATAGGAAGAGAAAAAAAGATCAATCTTGTATTTTCTGACCACATAAAGGCTTCTTCTCTTTGTAATAA

>44591_44591_11_LGR5-CNOT2_LGR5_chr12_71928966_ENST00000540815_CNOT2_chr12_70747609_ENST00000229195_length(amino acids)=151AA_BP=
MDTSRLGVLLSLPVLLQLATGGSSPRSGVLLRGCPTHCHCEPDGRMLLRVDCSDLGLSELPSNLSVFTSYLDLSMNNISQLLPNPLPSLR

--------------------------------------------------------------
>44591_44591_12_LGR5-CNOT2_LGR5_chr12_71928966_ENST00000540815_CNOT2_chr12_70747609_ENST00000418359_length(transcript)=1639nt_BP=474nt
CTGCTCTCCGCCCGCGTCCGGCTCGTGGCCCCCTACTTCGGGCACCATGGACACCTCCCGGCTCGGTGTGCTCCTGTCCTTGCCTGTGCT
GCTGCAGCTGGCGACCGGGGGCAGCTCTCCCAGGTCTGGTGTGTTGCTGAGGGGCTGCCCCACACACTGTCATTGCGAGCCCGACGGCAG
GATGTTGCTCAGGGTGGACTGCTCCGACCTGGGGCTCTCGGAGCTGCCTTCCAACCTCAGCGTCTTCACCTCCTACCTAGACCTCAGTAT
GAACAACATCAGTCAGCTGCTCCCGAATCCCCTGCCCAGTCTCCGCTTCCTGGAGGAGTTACGTCTTGCGGGAAACGCTCTGACATACAT
TCCCAAGGGAGCATTCACTGGCCTTTACAGTCTTAAAGTTCTTATGCTGCAGAATAATCAGCTAAGACACGTACCCACAGAAGCTCTGCA
GAATTTGCGAAGCCTTCAATCCCTGAGTTCCATCTGGAATATGACAAATTAGAAGAACGGCCTCACCTGCCATCCACCTTCAACTACAAC
CCTGCTCAGCAAGCCTTCTAAAAAAAAAAAAAAAAAAAAAAAAAGACTTCCCTTTTCTTGGGGTATGGCTGTCTCAGCACAATACTCAAC
ATAACTGCAGAACTGATGTGGCTCAGGCACCCTGGTTTTAATTCCTTGAGGATCTGGCAATTGGCTTACGCAAAAGGTCACCATTTGAGG
TCCTGCCTTACTAATTATGTGCTGCCCAACAACTAAATTTGTAATTTGTTTTTCTCTAGTTTGAGCAGGGTCTGAATTTTTTCATTTATT
TCCTTTTTTGCCAGCAGACAGACTTGAGTCTGTAAAGACAAGCAAATACACTGACAGAAGTTTACCATAGTTTCTAAAATGTAAAAAAGA
AAACCCCCAAAAGACTCAAGAAAATTAGACCACAAATTTTGCATTGTTCATTGTAGCACTATTGGTAATAAAATAACAAATGTTTGTGCA
TTTTTATGTGAAGATCCTTCTCGTATTTCATTTGGAAAGATGAGCAAGAGGTCTGCTTCCTTCATTTTACTTCCCCTTCTGTTTTTGAAA
GGCAGTTTCGCCAAGCTTAATGCAAGAATATCTGACTGTTTAGAAGAAAGATATTGCCACAATCTCTGGATGGTTTTCCAGGGTTGTGTT
ATTACTGAGCTTCATCTTTCCAGAATGAGCAAAACACTGTCCAGTCTTTGTTACGATTTTGTAATAAATGTGTACATTTTTTTTAAATTT
TTGGACATCACATGAATAAAGGTATGTATGTACGAATGTGTATATATTATATATATGACATCTATTTTGGAAAATGTTTGCCCTGCTGTA
CCTCATTTTTAGGAGGTGTGCATGGATGCAATATATGAAAATGGGACATTCTGGAACTGCTGGTCAGGGGACTTTGTCGCCCTGTGCACT
AAAAGGGCCAGATTTTCAGCAGCCAAGGACATCCATACCCAAGTGAATGTGATGGGACTTAAAAGAAGTGAACTGAGACAATTCACTCTG
GCTGTTTGAACAGCAGCGTTTCATAGGAAGAGAAAAAAAGATCAATCTTGTATTTTCTGACCACATAAAGGCTTCTTCTCTTTGTAATAA

>44591_44591_12_LGR5-CNOT2_LGR5_chr12_71928966_ENST00000540815_CNOT2_chr12_70747609_ENST00000418359_length(amino acids)=151AA_BP=
MDTSRLGVLLSLPVLLQLATGGSSPRSGVLLRGCPTHCHCEPDGRMLLRVDCSDLGLSELPSNLSVFTSYLDLSMNNISQLLPNPLPSLR

--------------------------------------------------------------

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Fusion Gene PPI Analysis for LGR5-CNOT2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for LGR5-CNOT2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for LGR5-CNOT2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource