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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:LHPP-TANGO6 (FusionGDB2 ID:44643)

Fusion Gene Summary for LHPP-TANGO6

Fusion gene summary

Fusion gene information	Fusion gene name: LHPP-TANGO6
	Fusion gene ID: 44643
		Hgene	Tgene
	Gene symbol	LHPP	TANGO6
	Gene ID	64077	79613
	Gene name	phospholysine phosphohistidine inorganic pyrophosphate phosphatase	transport and golgi organization 6 homolog
	Synonyms	HDHD2B	TMCO7
	Cytomap	10q26.13	16q22.1
	Type of gene	protein-coding	protein-coding
	Description	phospholysine phosphohistidine inorganic pyrophosphate phosphatasehLHPP	transport and Golgi organization protein 6 homologtransmembrane and coiled-coil domain-containing protein 7transmembrane and coiled-coil domains 7
	Modification date	20200313	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000368839, ENST00000368842, ENST00000392757, ENST00000482963,	ENST00000561931, ENST00000261778,
Fusion gene scores	* DoF score	6 X 8 X 3=144	12 X 15 X 6=1080
	# samples	8	18
	** MAII score	log2(8/144*10)=-0.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(18/1080*10)=-2.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: LHPP [Title/Abstract] AND TANGO6 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	LHPP(126172895)-TANGO6(69056731), # samples:2
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	LHPP	GO:0006796	phosphate-containing compound metabolic process	12801912

Fusion gene breakpoints across LHPP (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across TANGO6 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	HNSC	TCGA-CV-6948-01A	LHPP	chr10	126172895	+	TANGO6	chr16	69056731	+
ChimerDB4	HNSC	TCGA-CV-6948	LHPP	chr10	126172895	+	TANGO6	chr16	69056731	+

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Fusion Gene ORF analysis for LHPP-TANGO6

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000368839	ENST00000561931	LHPP	chr10	126172895	+	TANGO6	chr16	69056731	+
5CDS-intron	ENST00000368842	ENST00000561931	LHPP	chr10	126172895	+	TANGO6	chr16	69056731	+
5CDS-intron	ENST00000392757	ENST00000561931	LHPP	chr10	126172895	+	TANGO6	chr16	69056731	+
In-frame	ENST00000368839	ENST00000261778	LHPP	chr10	126172895	+	TANGO6	chr16	69056731	+
In-frame	ENST00000368842	ENST00000261778	LHPP	chr10	126172895	+	TANGO6	chr16	69056731	+
In-frame	ENST00000392757	ENST00000261778	LHPP	chr10	126172895	+	TANGO6	chr16	69056731	+
intron-3CDS	ENST00000482963	ENST00000261778	LHPP	chr10	126172895	+	TANGO6	chr16	69056731	+
intron-intron	ENST00000482963	ENST00000561931	LHPP	chr10	126172895	+	TANGO6	chr16	69056731	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000368842

LHPP

chr10

126172895

ENST00000261778

TANGO6

chr16

69056731

2303

341

783

251

ENST00000368839

LHPP

chr10

126172895

ENST00000261778

TANGO6

chr16

69056731

2295

333

775

251

ENST00000392757

LHPP

chr10

126172895

ENST00000261778

TANGO6

chr16

69056731

2304

342

784

251

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000368842	ENST00000261778	LHPP	chr10	126172895	+	TANGO6	chr16	69056731	+	0.00303078	0.9969693
ENST00000368839	ENST00000261778	LHPP	chr10	126172895	+	TANGO6	chr16	69056731	+	0.003209661	0.99679035
ENST00000392757	ENST00000261778	LHPP	chr10	126172895	+	TANGO6	chr16	69056731	+	0.002945768	0.9970542

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Fusion Genomic Features for LHPP-TANGO6

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
LHPP	chr10	126172895	+	TANGO6	chr16	69056730	+	8.35E-07	0.99999917
LHPP	chr10	126172895	+	TANGO6	chr16	69056730	+	8.35E-07	0.99999917
LHPP	chr10	126172895	+	TANGO6	chr16	69056730	+	8.35E-07	0.99999917
LHPP	chr10	126172895	+	TANGO6	chr16	69056730	+	8.35E-07	0.99999917

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for LHPP-TANGO6

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:126172895/chr16:69056731)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

LHPP

chr10:126172895

chr16:69056731

ENST00000368839

17_19

104

211.0

Region

Note=Substrate binding

Hgene

LHPP

chr10:126172895

chr16:69056731

ENST00000368839

54_55

104

211.0

Region

Note=Substrate binding

Hgene

LHPP

chr10:126172895

chr16:69056731

ENST00000368842

17_19

104

271.0

Region

Note=Substrate binding

Hgene

LHPP

chr10:126172895

chr16:69056731

ENST00000368842

54_55

104

271.0

Region

Note=Substrate binding

Tgene

TANGO6

chr10:126172895

chr16:69056731

ENST00000261778

952_988

947

1095.0

Repeat

Note=HEAT 2

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

TANGO6

chr10:126172895

chr16:69056731

ENST00000261778

873_909

947

1095.0

Repeat

Note=HEAT 1

Tgene

TANGO6

chr10:126172895

chr16:69056731

ENST00000261778

468_488

947

1095.0

Transmembrane

Helical

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Fusion Gene Sequence for LHPP-TANGO6

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>44643_44643_1_LHPP-TANGO6_LHPP_chr10_126172895_ENST00000368839_TANGO6_chr16_69056731_ENST00000261778_length(transcript)=2295nt_BP=333nt
GAGGAGCAGGGCCGGGCGCCATGGCACCGTGGGGCAAGCGGCTGGCTGGCGTGCGCGGGGTGCTGCTTGACATCTCGGGCGTGCTGTACG
ACAGCGGCGCGGGCGGCGGCACGGCCATCGCCGGCTCGGTGGAGGCGGTGGCCAGACTGAAGCGTTCCCGGCTGAAGGTGAGGTTCTGCA
CCAACGAGTCGCAGAAGTCCCGGGCAGAGCTGGTGGGGCAGCTTCAGAGGCTGGGATTTGACATCTCTGAGCAGGAGGTGACCGCCCCGG
CACCAGCTGCCTGCCAGATCCTGAAGGAGCAAGGCCTGCGACCATACCTGCTCATCCATGACGGAGACATGGTCTCAAAGTACCGAGAAC
CTTTGATCCATACCTTCCTGAGGGGAGTGAGAGATCCTGATGGTGCTCACAGGGCCAGCAGCTTGGCCAACCTTGGGGAGCTGTGCCAGA
GGCTGGACTTTCTGCTGGGCTCCGTGGTCCATGAGGTAACAGCTTGCCTGATTGCTGTGGCCAAAACAGATGGTGAAGTTCAAGTACGCA
GAGCTGCCATACATGTGGTTGTGCTGCTGCTTCGGGGACTCAGCCAGAAAGCTACTGAGGTGCTGAGCGCCGTCCTCAAGGATCTCTACC
ACCTGCTGAAGCACGTAGTGTGTCTGGAGCCCGATGACGTGGCCAAGCTCCATGCCCAGTTGGCCCTAGAAGAGCTGGATGACATCATGA
AAAACTTCCTGTTCCCTCCACAGAAGCTGGAGAAGAAGATCATGGTCCTGCCGTAGACCTGGCTCCAAGGACGTGGAGGAGGCAGGCAGG
GCCAGGCACCCAGAGCCGTGCCCAGGTCTTCCAGCAGGTGGCCCTGCTGCCTCTTGAGTGCTGGCAGCATGGCTGACCCTCGGGGTGGTT
TTATGGTGCAGGTCACTTGGGTCTTCAGGGTCCCTTCCGAGGGCATGTGTTCAGCACTCCCGCGTTCAGCCTGAGGGGTGTACAGTTAAG
AGAAGACAGTTACAGATCTCATTAATCTACATTTTTCACTGTCCTCTAGCATTGAAAGAAGGATGTCTACCTGGTGAAAGTATATTTTAA
CATGACTGATGGAATTTCACTAATTGCCCACTCTCTTGGAACTTGAGGAGAAGCGGTTGGCCACCCATATGTCACCTAGCTCTATATTCT
TTCAGGCTGAGATTCTTCTTCAGGAAAATGAGGAGCAGAACTGGCCACCCTTGGCTGCTCAAGAGGCATTTCAGAGTAGGAGATGCAGTT
GGAGGTGGGGAGGGGAAGGAAATAGTTATCAAATAATGCAAAATGGAATAAAGTTATCTTGGATGGAAAGAACAGGGCTAAATCTGGTCC
TCTGGTGTCGAGATGGAAAACTGTGGAGTTGAAGAGGCTCTGATGCCCAGAAAGGACAATCAAGCTGGTTGACTCTTCCAGAGAAGAAGG
GTAAGCCCTGTATTTATCCTCCCAGGCCATTCTTCTTCACTCCTGCTGCTGTTTGCAGAGAGTTGCCCTGATTATCAGGAGAAAAGAACC
ACGAGCATCCAGAGAGTTTACATCCTGCCTTCTGTCCTCTGCTCCTTCAGAAAGATGAATGCCTAGACAATGGGTTCACACTGAATGCAG
GCTGGAAAGAATGCATGCTGGTGGCCTAATGCCAGGGCTGTTGAAACAATTTCAGATATAGCACTGTGGTCTCCACTTTATTTCTTTATA
TGTTTTGGCCGCTGCATTTTGATTGCAGCTAAAAGAGATAACAGAAAGGAGATACTGGCTGGCTGCTTCATATTAGCCCTCTCTGTTGTC
AACACCTTGATGAGGCCAACCCAGAGATGCTTGATCAGTCCTCAGCTTTGCAGGGCTAGGTACAGAATTTTATCACAGGATTTTATCACG
CTCTCTGGGGTGACTAGATCCACAGGAACCAAAACGCAGTTTCCAAAAGCTCGAGTGACTGAAGGATCTATACACAAACATGGCTATTTG
CTAGTTAACAACAGGATATTTCTCTCTGGCCAGATCACAGACATGGTTCTGAGTCAGATCTTCCTTGGTGGCATCCCTTTAAAGAGGCCA
TCTTATGAACAGGATCACAAGTGAGCTTAGTGAGCAGAGAGTTAGAACAAATCTAGCTAGGTGTGTTTAAGGAATATTTCCATTCAGCTA
GTGTAGCTGGATTAATTTCTATTCTCCAAATCAAGGATGTCTAGAAAATGGGCATTGTGGCTTTCAAATCTAAGAAGAATCTCCTTTGGG

>44643_44643_1_LHPP-TANGO6_LHPP_chr10_126172895_ENST00000368839_TANGO6_chr16_69056731_ENST00000261778_length(amino acids)=251AA_BP=104
MAPWGKRLAGVRGVLLDISGVLYDSGAGGGTAIAGSVEAVARLKRSRLKVRFCTNESQKSRAELVGQLQRLGFDISEQEVTAPAPAACQI
LKEQGLRPYLLIHDGDMVSKYREPLIHTFLRGVRDPDGAHRASSLANLGELCQRLDFLLGSVVHEVTACLIAVAKTDGEVQVRRAAIHVV

--------------------------------------------------------------
>44643_44643_2_LHPP-TANGO6_LHPP_chr10_126172895_ENST00000368842_TANGO6_chr16_69056731_ENST00000261778_length(transcript)=2303nt_BP=341nt
GCGGAGCTGAGGAGCAGGGCCGGGCGCCATGGCACCGTGGGGCAAGCGGCTGGCTGGCGTGCGCGGGGTGCTGCTTGACATCTCGGGCGT
GCTGTACGACAGCGGCGCGGGCGGCGGCACGGCCATCGCCGGCTCGGTGGAGGCGGTGGCCAGACTGAAGCGTTCCCGGCTGAAGGTGAG
GTTCTGCACCAACGAGTCGCAGAAGTCCCGGGCAGAGCTGGTGGGGCAGCTTCAGAGGCTGGGATTTGACATCTCTGAGCAGGAGGTGAC
CGCCCCGGCACCAGCTGCCTGCCAGATCCTGAAGGAGCAAGGCCTGCGACCATACCTGCTCATCCATGACGGAGACATGGTCTCAAAGTA
CCGAGAACCTTTGATCCATACCTTCCTGAGGGGAGTGAGAGATCCTGATGGTGCTCACAGGGCCAGCAGCTTGGCCAACCTTGGGGAGCT
GTGCCAGAGGCTGGACTTTCTGCTGGGCTCCGTGGTCCATGAGGTAACAGCTTGCCTGATTGCTGTGGCCAAAACAGATGGTGAAGTTCA
AGTACGCAGAGCTGCCATACATGTGGTTGTGCTGCTGCTTCGGGGACTCAGCCAGAAAGCTACTGAGGTGCTGAGCGCCGTCCTCAAGGA
TCTCTACCACCTGCTGAAGCACGTAGTGTGTCTGGAGCCCGATGACGTGGCCAAGCTCCATGCCCAGTTGGCCCTAGAAGAGCTGGATGA
CATCATGAAAAACTTCCTGTTCCCTCCACAGAAGCTGGAGAAGAAGATCATGGTCCTGCCGTAGACCTGGCTCCAAGGACGTGGAGGAGG
CAGGCAGGGCCAGGCACCCAGAGCCGTGCCCAGGTCTTCCAGCAGGTGGCCCTGCTGCCTCTTGAGTGCTGGCAGCATGGCTGACCCTCG
GGGTGGTTTTATGGTGCAGGTCACTTGGGTCTTCAGGGTCCCTTCCGAGGGCATGTGTTCAGCACTCCCGCGTTCAGCCTGAGGGGTGTA
CAGTTAAGAGAAGACAGTTACAGATCTCATTAATCTACATTTTTCACTGTCCTCTAGCATTGAAAGAAGGATGTCTACCTGGTGAAAGTA
TATTTTAACATGACTGATGGAATTTCACTAATTGCCCACTCTCTTGGAACTTGAGGAGAAGCGGTTGGCCACCCATATGTCACCTAGCTC
TATATTCTTTCAGGCTGAGATTCTTCTTCAGGAAAATGAGGAGCAGAACTGGCCACCCTTGGCTGCTCAAGAGGCATTTCAGAGTAGGAG
ATGCAGTTGGAGGTGGGGAGGGGAAGGAAATAGTTATCAAATAATGCAAAATGGAATAAAGTTATCTTGGATGGAAAGAACAGGGCTAAA
TCTGGTCCTCTGGTGTCGAGATGGAAAACTGTGGAGTTGAAGAGGCTCTGATGCCCAGAAAGGACAATCAAGCTGGTTGACTCTTCCAGA
GAAGAAGGGTAAGCCCTGTATTTATCCTCCCAGGCCATTCTTCTTCACTCCTGCTGCTGTTTGCAGAGAGTTGCCCTGATTATCAGGAGA
AAAGAACCACGAGCATCCAGAGAGTTTACATCCTGCCTTCTGTCCTCTGCTCCTTCAGAAAGATGAATGCCTAGACAATGGGTTCACACT
GAATGCAGGCTGGAAAGAATGCATGCTGGTGGCCTAATGCCAGGGCTGTTGAAACAATTTCAGATATAGCACTGTGGTCTCCACTTTATT
TCTTTATATGTTTTGGCCGCTGCATTTTGATTGCAGCTAAAAGAGATAACAGAAAGGAGATACTGGCTGGCTGCTTCATATTAGCCCTCT
CTGTTGTCAACACCTTGATGAGGCCAACCCAGAGATGCTTGATCAGTCCTCAGCTTTGCAGGGCTAGGTACAGAATTTTATCACAGGATT
TTATCACGCTCTCTGGGGTGACTAGATCCACAGGAACCAAAACGCAGTTTCCAAAAGCTCGAGTGACTGAAGGATCTATACACAAACATG
GCTATTTGCTAGTTAACAACAGGATATTTCTCTCTGGCCAGATCACAGACATGGTTCTGAGTCAGATCTTCCTTGGTGGCATCCCTTTAA
AGAGGCCATCTTATGAACAGGATCACAAGTGAGCTTAGTGAGCAGAGAGTTAGAACAAATCTAGCTAGGTGTGTTTAAGGAATATTTCCA
TTCAGCTAGTGTAGCTGGATTAATTTCTATTCTCCAAATCAAGGATGTCTAGAAAATGGGCATTGTGGCTTTCAAATCTAAGAAGAATCT

>44643_44643_2_LHPP-TANGO6_LHPP_chr10_126172895_ENST00000368842_TANGO6_chr16_69056731_ENST00000261778_length(amino acids)=251AA_BP=104
MAPWGKRLAGVRGVLLDISGVLYDSGAGGGTAIAGSVEAVARLKRSRLKVRFCTNESQKSRAELVGQLQRLGFDISEQEVTAPAPAACQI
LKEQGLRPYLLIHDGDMVSKYREPLIHTFLRGVRDPDGAHRASSLANLGELCQRLDFLLGSVVHEVTACLIAVAKTDGEVQVRRAAIHVV

--------------------------------------------------------------
>44643_44643_3_LHPP-TANGO6_LHPP_chr10_126172895_ENST00000392757_TANGO6_chr16_69056731_ENST00000261778_length(transcript)=2304nt_BP=342nt
CGCGGAGCTGAGGAGCAGGGCCGGGCGCCATGGCACCGTGGGGCAAGCGGCTGGCTGGCGTGCGCGGGGTGCTGCTTGACATCTCGGGCG
TGCTGTACGACAGCGGCGCGGGCGGCGGCACGGCCATCGCCGGCTCGGTGGAGGCGGTGGCCAGACTGAAGCGTTCCCGGCTGAAGGTGA
GGTTCTGCACCAACGAGTCGCAGAAGTCCCGGGCAGAGCTGGTGGGGCAGCTTCAGAGGCTGGGATTTGACATCTCTGAGCAGGAGGTGA
CCGCCCCGGCACCAGCTGCCTGCCAGATCCTGAAGGAGCAAGGCCTGCGACCATACCTGCTCATCCATGACGGAGACATGGTCTCAAAGT
ACCGAGAACCTTTGATCCATACCTTCCTGAGGGGAGTGAGAGATCCTGATGGTGCTCACAGGGCCAGCAGCTTGGCCAACCTTGGGGAGC
TGTGCCAGAGGCTGGACTTTCTGCTGGGCTCCGTGGTCCATGAGGTAACAGCTTGCCTGATTGCTGTGGCCAAAACAGATGGTGAAGTTC
AAGTACGCAGAGCTGCCATACATGTGGTTGTGCTGCTGCTTCGGGGACTCAGCCAGAAAGCTACTGAGGTGCTGAGCGCCGTCCTCAAGG
ATCTCTACCACCTGCTGAAGCACGTAGTGTGTCTGGAGCCCGATGACGTGGCCAAGCTCCATGCCCAGTTGGCCCTAGAAGAGCTGGATG
ACATCATGAAAAACTTCCTGTTCCCTCCACAGAAGCTGGAGAAGAAGATCATGGTCCTGCCGTAGACCTGGCTCCAAGGACGTGGAGGAG
GCAGGCAGGGCCAGGCACCCAGAGCCGTGCCCAGGTCTTCCAGCAGGTGGCCCTGCTGCCTCTTGAGTGCTGGCAGCATGGCTGACCCTC
GGGGTGGTTTTATGGTGCAGGTCACTTGGGTCTTCAGGGTCCCTTCCGAGGGCATGTGTTCAGCACTCCCGCGTTCAGCCTGAGGGGTGT
ACAGTTAAGAGAAGACAGTTACAGATCTCATTAATCTACATTTTTCACTGTCCTCTAGCATTGAAAGAAGGATGTCTACCTGGTGAAAGT
ATATTTTAACATGACTGATGGAATTTCACTAATTGCCCACTCTCTTGGAACTTGAGGAGAAGCGGTTGGCCACCCATATGTCACCTAGCT
CTATATTCTTTCAGGCTGAGATTCTTCTTCAGGAAAATGAGGAGCAGAACTGGCCACCCTTGGCTGCTCAAGAGGCATTTCAGAGTAGGA
GATGCAGTTGGAGGTGGGGAGGGGAAGGAAATAGTTATCAAATAATGCAAAATGGAATAAAGTTATCTTGGATGGAAAGAACAGGGCTAA
ATCTGGTCCTCTGGTGTCGAGATGGAAAACTGTGGAGTTGAAGAGGCTCTGATGCCCAGAAAGGACAATCAAGCTGGTTGACTCTTCCAG
AGAAGAAGGGTAAGCCCTGTATTTATCCTCCCAGGCCATTCTTCTTCACTCCTGCTGCTGTTTGCAGAGAGTTGCCCTGATTATCAGGAG
AAAAGAACCACGAGCATCCAGAGAGTTTACATCCTGCCTTCTGTCCTCTGCTCCTTCAGAAAGATGAATGCCTAGACAATGGGTTCACAC
TGAATGCAGGCTGGAAAGAATGCATGCTGGTGGCCTAATGCCAGGGCTGTTGAAACAATTTCAGATATAGCACTGTGGTCTCCACTTTAT
TTCTTTATATGTTTTGGCCGCTGCATTTTGATTGCAGCTAAAAGAGATAACAGAAAGGAGATACTGGCTGGCTGCTTCATATTAGCCCTC
TCTGTTGTCAACACCTTGATGAGGCCAACCCAGAGATGCTTGATCAGTCCTCAGCTTTGCAGGGCTAGGTACAGAATTTTATCACAGGAT
TTTATCACGCTCTCTGGGGTGACTAGATCCACAGGAACCAAAACGCAGTTTCCAAAAGCTCGAGTGACTGAAGGATCTATACACAAACAT
GGCTATTTGCTAGTTAACAACAGGATATTTCTCTCTGGCCAGATCACAGACATGGTTCTGAGTCAGATCTTCCTTGGTGGCATCCCTTTA
AAGAGGCCATCTTATGAACAGGATCACAAGTGAGCTTAGTGAGCAGAGAGTTAGAACAAATCTAGCTAGGTGTGTTTAAGGAATATTTCC
ATTCAGCTAGTGTAGCTGGATTAATTTCTATTCTCCAAATCAAGGATGTCTAGAAAATGGGCATTGTGGCTTTCAAATCTAAGAAGAATC

>44643_44643_3_LHPP-TANGO6_LHPP_chr10_126172895_ENST00000392757_TANGO6_chr16_69056731_ENST00000261778_length(amino acids)=251AA_BP=104
MAPWGKRLAGVRGVLLDISGVLYDSGAGGGTAIAGSVEAVARLKRSRLKVRFCTNESQKSRAELVGQLQRLGFDISEQEVTAPAPAACQI
LKEQGLRPYLLIHDGDMVSKYREPLIHTFLRGVRDPDGAHRASSLANLGELCQRLDFLLGSVVHEVTACLIAVAKTDGEVQVRRAAIHVV

--------------------------------------------------------------

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Fusion Gene PPI Analysis for LHPP-TANGO6

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for LHPP-TANGO6

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for LHPP-TANGO6

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source