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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:LIG1-NUCB1 (FusionGDB2 ID:44664)

Fusion Gene Summary for LIG1-NUCB1

check button Fusion gene summary
Fusion gene informationFusion gene name: LIG1-NUCB1
Fusion gene ID: 44664
HgeneTgene
Gene symbol

LIG1

NUCB1

Gene ID

26018

4924

Gene nameleucine rich repeats and immunoglobulin like domains 1nucleobindin 1
SynonymsLIG-1|LIG1CALNUC|NUC
Cytomap

3p14.1

19q13.33

Type of geneprotein-codingprotein-coding
Descriptionleucine-rich repeats and immunoglobulin-like domains protein 1leucine-rich repeat protein LRIG1ortholog of mouse integral membrane glycoprotein LIG-1nucleobindin-1
Modification date2020032020200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000263274, ENST00000427526, 
ENST00000536218, ENST00000599165, 
ENST00000263273, ENST00000485798, 
ENST00000405315, ENST00000407032, 
Fusion gene scores* DoF score3 X 3 X 3=277 X 7 X 4=196
# samples 38
** MAII scorelog2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(8/196*10)=-1.29278174922785
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: LIG1 [Title/Abstract] AND NUCB1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointLIG1(48660270)-NUCB1(49414430), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across LIG1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across NUCB1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-E9-A1NA-01ALIG1chr19

48660270

-NUCB1chr19

49414430

-


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Fusion Gene ORF analysis for LIG1-NUCB1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000263274ENST00000263273LIG1chr19

48660270

-NUCB1chr19

49414430

-
5CDS-intronENST00000263274ENST00000485798LIG1chr19

48660270

-NUCB1chr19

49414430

-
5CDS-intronENST00000427526ENST00000263273LIG1chr19

48660270

-NUCB1chr19

49414430

-
5CDS-intronENST00000427526ENST00000485798LIG1chr19

48660270

-NUCB1chr19

49414430

-
5CDS-intronENST00000536218ENST00000263273LIG1chr19

48660270

-NUCB1chr19

49414430

-
5CDS-intronENST00000536218ENST00000485798LIG1chr19

48660270

-NUCB1chr19

49414430

-
In-frameENST00000263274ENST00000405315LIG1chr19

48660270

-NUCB1chr19

49414430

-
In-frameENST00000263274ENST00000407032LIG1chr19

48660270

-NUCB1chr19

49414430

-
In-frameENST00000427526ENST00000405315LIG1chr19

48660270

-NUCB1chr19

49414430

-
In-frameENST00000427526ENST00000407032LIG1chr19

48660270

-NUCB1chr19

49414430

-
In-frameENST00000536218ENST00000405315LIG1chr19

48660270

-NUCB1chr19

49414430

-
In-frameENST00000536218ENST00000407032LIG1chr19

48660270

-NUCB1chr19

49414430

-
intron-3CDSENST00000599165ENST00000405315LIG1chr19

48660270

-NUCB1chr19

49414430

-
intron-3CDSENST00000599165ENST00000407032LIG1chr19

48660270

-NUCB1chr19

49414430

-
intron-intronENST00000599165ENST00000263273LIG1chr19

48660270

-NUCB1chr19

49414430

-
intron-intronENST00000599165ENST00000485798LIG1chr19

48660270

-NUCB1chr19

49414430

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000263274LIG1chr1948660270-ENST00000405315NUCB1chr1949414430-27237907911774327
ENST00000263274LIG1chr1948660270-ENST00000407032NUCB1chr1949414430-24837907911774327
ENST00000536218LIG1chr1948660270-ENST00000405315NUCB1chr1949414430-24345015021485327
ENST00000536218LIG1chr1948660270-ENST00000407032NUCB1chr1949414430-21945015021485327
ENST00000427526LIG1chr1948660270-ENST00000405315NUCB1chr1949414430-23744414421425327
ENST00000427526LIG1chr1948660270-ENST00000407032NUCB1chr1949414430-21344414421425327

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000263274ENST00000405315LIG1chr1948660270-NUCB1chr1949414430-0.0032475750.9967525
ENST00000263274ENST00000407032LIG1chr1948660270-NUCB1chr1949414430-0.0040090970.99599093
ENST00000536218ENST00000405315LIG1chr1948660270-NUCB1chr1949414430-0.0030498880.9969501
ENST00000536218ENST00000407032LIG1chr1948660270-NUCB1chr1949414430-0.0036037160.99639636
ENST00000427526ENST00000405315LIG1chr1948660270-NUCB1chr1949414430-0.0030630650.9969369
ENST00000427526ENST00000407032LIG1chr1948660270-NUCB1chr1949414430-0.0036997490.9963003

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Fusion Genomic Features for LIG1-NUCB1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for LIG1-NUCB1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:48660270/chr19:49414430)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneNUCB1chr19:48660270chr19:49414430ENST00000263273012253_2640462.0Calcium binding1
TgeneNUCB1chr19:48660270chr19:49414430ENST00000263273012305_3160462.0Calcium binding2
TgeneNUCB1chr19:48660270chr19:49414430ENST00000405315013253_2640462.0Calcium binding1
TgeneNUCB1chr19:48660270chr19:49414430ENST00000405315013305_3160462.0Calcium binding2
TgeneNUCB1chr19:48660270chr19:49414430ENST00000407032014253_2640666.6666666666666Calcium binding1
TgeneNUCB1chr19:48660270chr19:49414430ENST00000407032014305_3160666.6666666666666Calcium binding2
TgeneNUCB1chr19:48660270chr19:49414430ENST00000263273012150_2180462.0Coiled coilOntology_term=ECO:0000255
TgeneNUCB1chr19:48660270chr19:49414430ENST00000263273012341_4070462.0Coiled coilOntology_term=ECO:0000255
TgeneNUCB1chr19:48660270chr19:49414430ENST00000405315013150_2180462.0Coiled coilOntology_term=ECO:0000255
TgeneNUCB1chr19:48660270chr19:49414430ENST00000405315013341_4070462.0Coiled coilOntology_term=ECO:0000255
TgeneNUCB1chr19:48660270chr19:49414430ENST00000407032014150_2180666.6666666666666Coiled coilOntology_term=ECO:0000255
TgeneNUCB1chr19:48660270chr19:49414430ENST00000407032014341_4070666.6666666666666Coiled coilOntology_term=ECO:0000255
TgeneNUCB1chr19:48660270chr19:49414430ENST00000263273012401_4070462.0Compositional biasNote=Poly-Gln
TgeneNUCB1chr19:48660270chr19:49414430ENST00000405315013401_4070462.0Compositional biasNote=Poly-Gln
TgeneNUCB1chr19:48660270chr19:49414430ENST00000407032014401_4070666.6666666666666Compositional biasNote=Poly-Gln
TgeneNUCB1chr19:48660270chr19:49414430ENST00000263273012172_2180462.0DNA bindingOntology_term=ECO:0000255
TgeneNUCB1chr19:48660270chr19:49414430ENST00000405315013172_2180462.0DNA bindingOntology_term=ECO:0000255
TgeneNUCB1chr19:48660270chr19:49414430ENST00000407032014172_2180666.6666666666666DNA bindingOntology_term=ECO:0000255
TgeneNUCB1chr19:48660270chr19:49414430ENST00000263273012240_2750462.0DomainEF-hand 1
TgeneNUCB1chr19:48660270chr19:49414430ENST00000263273012292_3270462.0DomainEF-hand 2
TgeneNUCB1chr19:48660270chr19:49414430ENST00000405315013240_2750462.0DomainEF-hand 1
TgeneNUCB1chr19:48660270chr19:49414430ENST00000405315013292_3270462.0DomainEF-hand 2
TgeneNUCB1chr19:48660270chr19:49414430ENST00000407032014240_2750666.6666666666666DomainEF-hand 1
TgeneNUCB1chr19:48660270chr19:49414430ENST00000407032014292_3270666.6666666666666DomainEF-hand 2
TgeneNUCB1chr19:48660270chr19:49414430ENST00000263273012303_3330462.0MotifGBA
TgeneNUCB1chr19:48660270chr19:49414430ENST00000405315013303_3330462.0MotifGBA
TgeneNUCB1chr19:48660270chr19:49414430ENST00000407032014303_3330666.6666666666666MotifGBA
TgeneNUCB1chr19:48660270chr19:49414430ENST00000263273012228_3210462.0RegionBinds to GNAI2 and GNAI3
TgeneNUCB1chr19:48660270chr19:49414430ENST0000026327301242_510462.0RegionNote=O-glycosylated at one site
TgeneNUCB1chr19:48660270chr19:49414430ENST00000405315013228_3210462.0RegionBinds to GNAI2 and GNAI3
TgeneNUCB1chr19:48660270chr19:49414430ENST0000040531501342_510462.0RegionNote=O-glycosylated at one site
TgeneNUCB1chr19:48660270chr19:49414430ENST00000407032014228_3210666.6666666666666RegionBinds to GNAI2 and GNAI3
TgeneNUCB1chr19:48660270chr19:49414430ENST0000040703201442_510666.6666666666666RegionNote=O-glycosylated at one site

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for LIG1-NUCB1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>44664_44664_1_LIG1-NUCB1_LIG1_chr19_48660270_ENST00000263274_NUCB1_chr19_49414430_ENST00000405315_length(transcript)=2723nt_BP=790nt
CTCGCGGGGGCGCTTCCACCGATTCCTCCTCTTTCCCTGCCAGTCACTCCTCAGACCCTCAGCCACACCCGCTCATCCAGGGCGAGGGAA
AGCGCGGGCATTTTCCCAGTGTGCTCTGCGGGAGGGCTCGCCCCACTTCACCCCTTTTCCCGCCCTCCTCCCATTCGGGAGACTACGACT
CCCAGTGTCCTCCGCGCGACGGCGGCGGTGCGGACGGTGCCCAGGTCCCGCCCCTAGGCTCTGCCCCGCCCCCGCCCGCAGACGTCTGCG
CGCGAATGCCGTGGCGCGAACTTGGGACTGCAGAGGCGCGCCTGGCGGATCTGAGTGTGTTGCCCGGGCAGCGGCGCGCGGGACCAACGC
AAGGAGCAGCTGACAGACGAAGAAAAGTGCTGGACAGGAAGGGAGAATTCTGACGCCAACATGCAGCGAAGTATCATGTCATTTTTCCAC
CCCAAGAAAGAGGGTAAAGCAAAGAAGCCTGAGAAGGAGGCATCCAATAGCAGCAGAGAGACGGAGCCCCCTCCAAAGGCGGCACTGAAG
GAGTGGAATGGAGTGGTGTCCGAGAGTGACTCTCCGGTGAAGAGGCCAGGGAGGAAGGCGGCCCGGGTCCTGGGCAGCGAAGGGGAAGAG
GAGGATGAAGCCCTTAGCCCTGCTAAAGGCCAGAAGCCTGCCCTGGACTGCTCACAGGTCTCCCCGCCCCGTCCTGCCACATCTCCTGAG
AACAATGCTTCCCTCTCTGACACCTCTCCCATGGACAGTTCCCCATCAGGGATTCCGAAGCGTCGCACAGCCTGAAACAGTTTGAACACC
TGGACCCTCAGAACCAGCATACATTCGAGGCCCGCGACCTGGAGCTGCTGATCCAGACGGCCACCCGGGACCTTGCCCAGTACGACGCAG
CCCATCATGAAGAGTTCAAGCGCTACGAGATGCTTAAGGAACACGAGAGACGGCGTTATCTGGAGTCACTGGGAGAGGAGCAGAGAAAGG
AGGCGGAGAGGAAGCTGGAAGAGCAACAGCGCCGGCACCGCGAGCACCCTAAAGTCAACGTGCCTGGCAGCCAAGCCCAGTTGAAGGAGG
TGTGGGAGGAGCTGGATGGACTGGACCCCAACAGGTTTAACCCCAAGACCTTCTTCATACTGCATGATATCAACAGTGATGGTGTCCTGG
ATGAGCAGGAGCTGGAGGCACTCTTCACCAAGGAGCTGGAGAAAGTGTACGACCCAAAGAATGAGGAGGACGACATGCGGGAGATGGAGG
AGGAGCGACTGCGCATGCGGGAGCATGTGATGAAGAATGTGGACACCAACCAGGACCGCCTCGTGACCCTGGAGGAGTTCCTCGCATCCA
CTCAGAGGAAGGAGTTTGGGGACACCGGGGAGGGCTGGGAGACAGTGGAGATGCACCCTGCCTACACCGAGGAAGAGCTGAGGCGCTTTG
AAGAGGAGCTGGCTGCCCGGGAGGCAGAGCTGAATGCCAAGGCCCAGCGCCTCAGCCAGGAGACAGAGGCTCTAGGGCGGTCCCAGGGCC
GCCTGGAGGCCCAGAAGAGAGAGCTGCAGCAGGCTGTGCTGCACATGGAGCAGCGGAAGCAGCAGCAGCAGCAGCAGCAAGGCCACAAGG
CCCCGGCTGCCCACCCTGAGGGGCAGCTCAAGTTCCACCCAGACACAGACGATGTACCTGTCCCAGCTCCAGCCGGTGACCAGAAGGAGG
TGGACACTTCAGAAAAGAAACTTCTCGAGCGGCTCCCTGAGGTTGAGGTGCCCCAGCATCTGTGATCCTCCGGGACCCCAGCCCTCAGGA
TTCCTGATGCTCCAAGGCGACTGATGGGCGCTGGATGAAGTGGCACAGTCAGCTTCCCTGGGGGCTGGTGTCATGTTGGGCTCCTGGGGC
GGGGGCACGGCCTGGCATTTCACGCATTGCTGCCACCCCAGGTCCACCTGTCTCCACTTTCACAGCCTCCAAGTCTGTGGCTCTTCCCTT
CTGTCCTCCGAGGGGCTTGCCTTCTCTCGTGTCCAGTGAGGTGCTCAGTGATCGGCTTAACTTAGAGAAGCCCGCCCCCTCCCCTTCTCC
GTCTGTCCCAAGAGGGTCTGCTCTGAGCCTGCGTTCCTAGGTGGCTCGGCCTCAGCTGCCTGGGTTGTGGCCGCCCTAGCATCCTGTATG
CCCACAGCTACTGGAATCCCCGCTGCTGCTCCGGGCCAAGCTTCTGGTTGATTAATGAGGGCATGGGGTGGTCCCTCAAGACCTTCCCCT
ACCTTTTGTGGAACCAGTGATGCCTCAAAGACAGTGTCCCCTCCACAGCTGGGTGCCAGGGGCAGGGGATCCTCAGTATAGCCGGTGAAC
CCTGATACCAGGAGCCTGGGCCTCCCTGAACCCCTGGCTTCCAGCCATCTCATCGCCAGCCTCCTCCTGGACCTCTTGGCCCCCAGCCCC
TTCCCCACACAGCCCCAGAAGGGTCCCAGAGCTGACCCCACTCCAGGACCTAGGCCCAGCCCCTCAGCCTCATCTGGAGCCCCTGAAGAC
CAGTCCCACCCACCTTTCTGGCCTCATCTGACACTGCTCCGCATCCTGCTGTGTGTCCTGTTCCATGTTCCGGTTCCATCCAAATACACT
TTCTGGAACAAATGCATGGCTCCATGCCTGTGTATCTGGACTGGTCCCTCCAAAACGCTATTGCCACGTCACCTGCCGGAGTCCTCATCT

>44664_44664_1_LIG1-NUCB1_LIG1_chr19_48660270_ENST00000263274_NUCB1_chr19_49414430_ENST00000405315_length(amino acids)=327AA_BP=1
MKQFEHLDPQNQHTFEARDLELLIQTATRDLAQYDAAHHEEFKRYEMLKEHERRRYLESLGEEQRKEAERKLEEQQRRHREHPKVNVPGS
QAQLKEVWEELDGLDPNRFNPKTFFILHDINSDGVLDEQELEALFTKELEKVYDPKNEEDDMREMEEERLRMREHVMKNVDTNQDRLVTL
EEFLASTQRKEFGDTGEGWETVEMHPAYTEEELRRFEEELAAREAELNAKAQRLSQETEALGRSQGRLEAQKRELQQAVLHMEQRKQQQQ

--------------------------------------------------------------
>44664_44664_2_LIG1-NUCB1_LIG1_chr19_48660270_ENST00000263274_NUCB1_chr19_49414430_ENST00000407032_length(transcript)=2483nt_BP=790nt
CTCGCGGGGGCGCTTCCACCGATTCCTCCTCTTTCCCTGCCAGTCACTCCTCAGACCCTCAGCCACACCCGCTCATCCAGGGCGAGGGAA
AGCGCGGGCATTTTCCCAGTGTGCTCTGCGGGAGGGCTCGCCCCACTTCACCCCTTTTCCCGCCCTCCTCCCATTCGGGAGACTACGACT
CCCAGTGTCCTCCGCGCGACGGCGGCGGTGCGGACGGTGCCCAGGTCCCGCCCCTAGGCTCTGCCCCGCCCCCGCCCGCAGACGTCTGCG
CGCGAATGCCGTGGCGCGAACTTGGGACTGCAGAGGCGCGCCTGGCGGATCTGAGTGTGTTGCCCGGGCAGCGGCGCGCGGGACCAACGC
AAGGAGCAGCTGACAGACGAAGAAAAGTGCTGGACAGGAAGGGAGAATTCTGACGCCAACATGCAGCGAAGTATCATGTCATTTTTCCAC
CCCAAGAAAGAGGGTAAAGCAAAGAAGCCTGAGAAGGAGGCATCCAATAGCAGCAGAGAGACGGAGCCCCCTCCAAAGGCGGCACTGAAG
GAGTGGAATGGAGTGGTGTCCGAGAGTGACTCTCCGGTGAAGAGGCCAGGGAGGAAGGCGGCCCGGGTCCTGGGCAGCGAAGGGGAAGAG
GAGGATGAAGCCCTTAGCCCTGCTAAAGGCCAGAAGCCTGCCCTGGACTGCTCACAGGTCTCCCCGCCCCGTCCTGCCACATCTCCTGAG
AACAATGCTTCCCTCTCTGACACCTCTCCCATGGACAGTTCCCCATCAGGGATTCCGAAGCGTCGCACAGCCTGAAACAGTTTGAACACC
TGGACCCTCAGAACCAGCATACATTCGAGGCCCGCGACCTGGAGCTGCTGATCCAGACGGCCACCCGGGACCTTGCCCAGTACGACGCAG
CCCATCATGAAGAGTTCAAGCGCTACGAGATGCTTAAGGAACACGAGAGACGGCGTTATCTGGAGTCACTGGGAGAGGAGCAGAGAAAGG
AGGCGGAGAGGAAGCTGGAAGAGCAACAGCGCCGGCACCGCGAGCACCCTAAAGTCAACGTGCCTGGCAGCCAAGCCCAGTTGAAGGAGG
TGTGGGAGGAGCTGGATGGACTGGACCCCAACAGGTTTAACCCCAAGACCTTCTTCATACTGCATGATATCAACAGTGATGGTGTCCTGG
ATGAGCAGGAGCTGGAGGCACTCTTCACCAAGGAGCTGGAGAAAGTGTACGACCCAAAGAATGAGGAGGACGACATGCGGGAGATGGAGG
AGGAGCGACTGCGCATGCGGGAGCATGTGATGAAGAATGTGGACACCAACCAGGACCGCCTCGTGACCCTGGAGGAGTTCCTCGCATCCA
CTCAGAGGAAGGAGTTTGGGGACACCGGGGAGGGCTGGGAGACAGTGGAGATGCACCCTGCCTACACCGAGGAAGAGCTGAGGCGCTTTG
AAGAGGAGCTGGCTGCCCGGGAGGCAGAGCTGAATGCCAAGGCCCAGCGCCTCAGCCAGGAGACAGAGGCTCTAGGGCGGTCCCAGGGCC
GCCTGGAGGCCCAGAAGAGAGAGCTGCAGCAGGCTGTGCTGCACATGGAGCAGCGGAAGCAGCAGCAGCAGCAGCAGCAAGGCCACAAGG
CCCCGGCTGCCCACCCTGAGGGGCAGCTCAAGTTCCACCCAGACACAGACGATGTACCTGTCCCAGCTCCAGCCGGTGACCAGAAGGAGG
TGGACACTTCAGAAAAGAAACTTCTCGAGCGGCTCCCTGAGGTTGAGGTGCCCCAGCATCTGTGATCCTCCGGGACCCCAGCCCTCAGGA
TTCCTGATGCTCCAAGCCTCCAAGTCTGTGGCTCTTCCCTTCTGTCCTCCGAGGGGCTTGCCTTCTCTCGTGTCCAGTGAGGTGCTCAGT
GATCGGCTTAACTTAGAGAAGCCCGCCCCCTCCCCTTCTCCGTCTGTCCCAAGAGGGTCTGCTCTGAGCCTGCGTTCCTAGGTGGCTCGG
CCTCAGCTGCCTGGGTTGTGGCCGCCCTAGCATCCTGTATGCCCACAGCTACTGGAATCCCCGCTGCTGCTCCGGGCCAAGCTTCTGGTT
GATTAATGAGGGCATGGGGTGGTCCCTCAAGACCTTCCCCTACCTTTTGTGGAACCAGTGATGCCTCAAAGACAGTGTCCCCTCCACAGC
TGGGTGCCAGGGGCAGGGGATCCTCAGTATAGCCGGTGAACCCTGATACCAGGAGCCTGGGCCTCCCTGAACCCCTGGCTTCCAGCCATC
TCATCGCCAGCCTCCTCCTGGACCTCTTGGCCCCCAGCCCCTTCCCCACACAGCCCCAGAAGGGTCCCAGAGCTGACCCCACTCCAGGAC
CTAGGCCCAGCCCCTCAGCCTCATCTGGAGCCCCTGAAGACCAGTCCCACCCACCTTTCTGGCCTCATCTGACACTGCTCCGCATCCTGC

>44664_44664_2_LIG1-NUCB1_LIG1_chr19_48660270_ENST00000263274_NUCB1_chr19_49414430_ENST00000407032_length(amino acids)=327AA_BP=1
MKQFEHLDPQNQHTFEARDLELLIQTATRDLAQYDAAHHEEFKRYEMLKEHERRRYLESLGEEQRKEAERKLEEQQRRHREHPKVNVPGS
QAQLKEVWEELDGLDPNRFNPKTFFILHDINSDGVLDEQELEALFTKELEKVYDPKNEEDDMREMEEERLRMREHVMKNVDTNQDRLVTL
EEFLASTQRKEFGDTGEGWETVEMHPAYTEEELRRFEEELAAREAELNAKAQRLSQETEALGRSQGRLEAQKRELQQAVLHMEQRKQQQQ

--------------------------------------------------------------
>44664_44664_3_LIG1-NUCB1_LIG1_chr19_48660270_ENST00000427526_NUCB1_chr19_49414430_ENST00000405315_length(transcript)=2374nt_BP=441nt
AGACGTCTGCGCGCGAATGCCGTGGCGCGAACTTGGGACTGCAGAGGCGCGCCTGGCGGATCTGAGTGTGTTGCCCGGGCAGCGGCGCGC
GGGACCAACGCAAGGAGCAGCTGACAGACGAAGAAAAGTGCTGGACAGGAAGGGAGAATTCTGACGCCAACATGCAGCGAAGTATCATGG
CGGCACTGAAGGAGTGGAATGGAGTGGTGTCCGAGAGTGACTCTCCGGTGAAGAGGCCAGGGAGGAAGGCGGCCCGGGTCCTGGGCAGCG
AAGGGGAAGAGGAGGATGAAGCCCTTAGCCCTGCTAAAGGCCAGAAGCCTGCCCTGGACTGCTCACAGGTCTCCCCGCCCCGTCCTGCCA
CATCTCCTGAGAACAATGCTTCCCTCTCTGACACCTCTCCCATGGACAGTTCCCCATCAGGGATTCCGAAGCGTCGCACAGCCTGAAACA
GTTTGAACACCTGGACCCTCAGAACCAGCATACATTCGAGGCCCGCGACCTGGAGCTGCTGATCCAGACGGCCACCCGGGACCTTGCCCA
GTACGACGCAGCCCATCATGAAGAGTTCAAGCGCTACGAGATGCTTAAGGAACACGAGAGACGGCGTTATCTGGAGTCACTGGGAGAGGA
GCAGAGAAAGGAGGCGGAGAGGAAGCTGGAAGAGCAACAGCGCCGGCACCGCGAGCACCCTAAAGTCAACGTGCCTGGCAGCCAAGCCCA
GTTGAAGGAGGTGTGGGAGGAGCTGGATGGACTGGACCCCAACAGGTTTAACCCCAAGACCTTCTTCATACTGCATGATATCAACAGTGA
TGGTGTCCTGGATGAGCAGGAGCTGGAGGCACTCTTCACCAAGGAGCTGGAGAAAGTGTACGACCCAAAGAATGAGGAGGACGACATGCG
GGAGATGGAGGAGGAGCGACTGCGCATGCGGGAGCATGTGATGAAGAATGTGGACACCAACCAGGACCGCCTCGTGACCCTGGAGGAGTT
CCTCGCATCCACTCAGAGGAAGGAGTTTGGGGACACCGGGGAGGGCTGGGAGACAGTGGAGATGCACCCTGCCTACACCGAGGAAGAGCT
GAGGCGCTTTGAAGAGGAGCTGGCTGCCCGGGAGGCAGAGCTGAATGCCAAGGCCCAGCGCCTCAGCCAGGAGACAGAGGCTCTAGGGCG
GTCCCAGGGCCGCCTGGAGGCCCAGAAGAGAGAGCTGCAGCAGGCTGTGCTGCACATGGAGCAGCGGAAGCAGCAGCAGCAGCAGCAGCA
AGGCCACAAGGCCCCGGCTGCCCACCCTGAGGGGCAGCTCAAGTTCCACCCAGACACAGACGATGTACCTGTCCCAGCTCCAGCCGGTGA
CCAGAAGGAGGTGGACACTTCAGAAAAGAAACTTCTCGAGCGGCTCCCTGAGGTTGAGGTGCCCCAGCATCTGTGATCCTCCGGGACCCC
AGCCCTCAGGATTCCTGATGCTCCAAGGCGACTGATGGGCGCTGGATGAAGTGGCACAGTCAGCTTCCCTGGGGGCTGGTGTCATGTTGG
GCTCCTGGGGCGGGGGCACGGCCTGGCATTTCACGCATTGCTGCCACCCCAGGTCCACCTGTCTCCACTTTCACAGCCTCCAAGTCTGTG
GCTCTTCCCTTCTGTCCTCCGAGGGGCTTGCCTTCTCTCGTGTCCAGTGAGGTGCTCAGTGATCGGCTTAACTTAGAGAAGCCCGCCCCC
TCCCCTTCTCCGTCTGTCCCAAGAGGGTCTGCTCTGAGCCTGCGTTCCTAGGTGGCTCGGCCTCAGCTGCCTGGGTTGTGGCCGCCCTAG
CATCCTGTATGCCCACAGCTACTGGAATCCCCGCTGCTGCTCCGGGCCAAGCTTCTGGTTGATTAATGAGGGCATGGGGTGGTCCCTCAA
GACCTTCCCCTACCTTTTGTGGAACCAGTGATGCCTCAAAGACAGTGTCCCCTCCACAGCTGGGTGCCAGGGGCAGGGGATCCTCAGTAT
AGCCGGTGAACCCTGATACCAGGAGCCTGGGCCTCCCTGAACCCCTGGCTTCCAGCCATCTCATCGCCAGCCTCCTCCTGGACCTCTTGG
CCCCCAGCCCCTTCCCCACACAGCCCCAGAAGGGTCCCAGAGCTGACCCCACTCCAGGACCTAGGCCCAGCCCCTCAGCCTCATCTGGAG
CCCCTGAAGACCAGTCCCACCCACCTTTCTGGCCTCATCTGACACTGCTCCGCATCCTGCTGTGTGTCCTGTTCCATGTTCCGGTTCCAT
CCAAATACACTTTCTGGAACAAATGCATGGCTCCATGCCTGTGTATCTGGACTGGTCCCTCCAAAACGCTATTGCCACGTCACCTGCCGG

>44664_44664_3_LIG1-NUCB1_LIG1_chr19_48660270_ENST00000427526_NUCB1_chr19_49414430_ENST00000405315_length(amino acids)=327AA_BP=1
MKQFEHLDPQNQHTFEARDLELLIQTATRDLAQYDAAHHEEFKRYEMLKEHERRRYLESLGEEQRKEAERKLEEQQRRHREHPKVNVPGS
QAQLKEVWEELDGLDPNRFNPKTFFILHDINSDGVLDEQELEALFTKELEKVYDPKNEEDDMREMEEERLRMREHVMKNVDTNQDRLVTL
EEFLASTQRKEFGDTGEGWETVEMHPAYTEEELRRFEEELAAREAELNAKAQRLSQETEALGRSQGRLEAQKRELQQAVLHMEQRKQQQQ

--------------------------------------------------------------
>44664_44664_4_LIG1-NUCB1_LIG1_chr19_48660270_ENST00000427526_NUCB1_chr19_49414430_ENST00000407032_length(transcript)=2134nt_BP=441nt
AGACGTCTGCGCGCGAATGCCGTGGCGCGAACTTGGGACTGCAGAGGCGCGCCTGGCGGATCTGAGTGTGTTGCCCGGGCAGCGGCGCGC
GGGACCAACGCAAGGAGCAGCTGACAGACGAAGAAAAGTGCTGGACAGGAAGGGAGAATTCTGACGCCAACATGCAGCGAAGTATCATGG
CGGCACTGAAGGAGTGGAATGGAGTGGTGTCCGAGAGTGACTCTCCGGTGAAGAGGCCAGGGAGGAAGGCGGCCCGGGTCCTGGGCAGCG
AAGGGGAAGAGGAGGATGAAGCCCTTAGCCCTGCTAAAGGCCAGAAGCCTGCCCTGGACTGCTCACAGGTCTCCCCGCCCCGTCCTGCCA
CATCTCCTGAGAACAATGCTTCCCTCTCTGACACCTCTCCCATGGACAGTTCCCCATCAGGGATTCCGAAGCGTCGCACAGCCTGAAACA
GTTTGAACACCTGGACCCTCAGAACCAGCATACATTCGAGGCCCGCGACCTGGAGCTGCTGATCCAGACGGCCACCCGGGACCTTGCCCA
GTACGACGCAGCCCATCATGAAGAGTTCAAGCGCTACGAGATGCTTAAGGAACACGAGAGACGGCGTTATCTGGAGTCACTGGGAGAGGA
GCAGAGAAAGGAGGCGGAGAGGAAGCTGGAAGAGCAACAGCGCCGGCACCGCGAGCACCCTAAAGTCAACGTGCCTGGCAGCCAAGCCCA
GTTGAAGGAGGTGTGGGAGGAGCTGGATGGACTGGACCCCAACAGGTTTAACCCCAAGACCTTCTTCATACTGCATGATATCAACAGTGA
TGGTGTCCTGGATGAGCAGGAGCTGGAGGCACTCTTCACCAAGGAGCTGGAGAAAGTGTACGACCCAAAGAATGAGGAGGACGACATGCG
GGAGATGGAGGAGGAGCGACTGCGCATGCGGGAGCATGTGATGAAGAATGTGGACACCAACCAGGACCGCCTCGTGACCCTGGAGGAGTT
CCTCGCATCCACTCAGAGGAAGGAGTTTGGGGACACCGGGGAGGGCTGGGAGACAGTGGAGATGCACCCTGCCTACACCGAGGAAGAGCT
GAGGCGCTTTGAAGAGGAGCTGGCTGCCCGGGAGGCAGAGCTGAATGCCAAGGCCCAGCGCCTCAGCCAGGAGACAGAGGCTCTAGGGCG
GTCCCAGGGCCGCCTGGAGGCCCAGAAGAGAGAGCTGCAGCAGGCTGTGCTGCACATGGAGCAGCGGAAGCAGCAGCAGCAGCAGCAGCA
AGGCCACAAGGCCCCGGCTGCCCACCCTGAGGGGCAGCTCAAGTTCCACCCAGACACAGACGATGTACCTGTCCCAGCTCCAGCCGGTGA
CCAGAAGGAGGTGGACACTTCAGAAAAGAAACTTCTCGAGCGGCTCCCTGAGGTTGAGGTGCCCCAGCATCTGTGATCCTCCGGGACCCC
AGCCCTCAGGATTCCTGATGCTCCAAGCCTCCAAGTCTGTGGCTCTTCCCTTCTGTCCTCCGAGGGGCTTGCCTTCTCTCGTGTCCAGTG
AGGTGCTCAGTGATCGGCTTAACTTAGAGAAGCCCGCCCCCTCCCCTTCTCCGTCTGTCCCAAGAGGGTCTGCTCTGAGCCTGCGTTCCT
AGGTGGCTCGGCCTCAGCTGCCTGGGTTGTGGCCGCCCTAGCATCCTGTATGCCCACAGCTACTGGAATCCCCGCTGCTGCTCCGGGCCA
AGCTTCTGGTTGATTAATGAGGGCATGGGGTGGTCCCTCAAGACCTTCCCCTACCTTTTGTGGAACCAGTGATGCCTCAAAGACAGTGTC
CCCTCCACAGCTGGGTGCCAGGGGCAGGGGATCCTCAGTATAGCCGGTGAACCCTGATACCAGGAGCCTGGGCCTCCCTGAACCCCTGGC
TTCCAGCCATCTCATCGCCAGCCTCCTCCTGGACCTCTTGGCCCCCAGCCCCTTCCCCACACAGCCCCAGAAGGGTCCCAGAGCTGACCC
CACTCCAGGACCTAGGCCCAGCCCCTCAGCCTCATCTGGAGCCCCTGAAGACCAGTCCCACCCACCTTTCTGGCCTCATCTGACACTGCT

>44664_44664_4_LIG1-NUCB1_LIG1_chr19_48660270_ENST00000427526_NUCB1_chr19_49414430_ENST00000407032_length(amino acids)=327AA_BP=1
MKQFEHLDPQNQHTFEARDLELLIQTATRDLAQYDAAHHEEFKRYEMLKEHERRRYLESLGEEQRKEAERKLEEQQRRHREHPKVNVPGS
QAQLKEVWEELDGLDPNRFNPKTFFILHDINSDGVLDEQELEALFTKELEKVYDPKNEEDDMREMEEERLRMREHVMKNVDTNQDRLVTL
EEFLASTQRKEFGDTGEGWETVEMHPAYTEEELRRFEEELAAREAELNAKAQRLSQETEALGRSQGRLEAQKRELQQAVLHMEQRKQQQQ

--------------------------------------------------------------
>44664_44664_5_LIG1-NUCB1_LIG1_chr19_48660270_ENST00000536218_NUCB1_chr19_49414430_ENST00000405315_length(transcript)=2434nt_BP=501nt
ACTTGGGACTGCAGAGGCGCGCCTGGCGGATCTGAGTGTGTTGCCCGGGCAGCGGCGCGCGGGACCAACGCAAGGAGCAGCTGACAGACG
AAGAAAAGTGCTGGACAGGAAGGGAGAATTCTGACGCCAACATGCAGCGAAGTATCATGTCATTTTTCCACCCCAAGAAAGAGGGTAAAG
CAAAGAAGCCTGAGAAGGAGGCATCCAATAGCAGCAGAGAGACGGAGCCCCCTCCAAAGGCGGCACTGAAGGAGTGGAATGGAGTGGTGT
CCGAGAGTGACTCTCCGGTGAAGAGGCCAGGGAGGAAGGCGGCCCGGGTCCTGGGCAGCGAAGGGGAAGAGGAGGATGAAGCCCTTAGCC
CTGCTAAAGGCCAGAAGCCTGCCCTGGACTGCTCACAGGTCTCCCCGCCCCGTCCTGCCACATCTCCTGAGAACAATGCTTCCCTCTCTG
ACACCTCTCCCATGGACAGTTCCCCATCAGGGATTCCGAAGCGTCGCACAGCCTGAAACAGTTTGAACACCTGGACCCTCAGAACCAGCA
TACATTCGAGGCCCGCGACCTGGAGCTGCTGATCCAGACGGCCACCCGGGACCTTGCCCAGTACGACGCAGCCCATCATGAAGAGTTCAA
GCGCTACGAGATGCTTAAGGAACACGAGAGACGGCGTTATCTGGAGTCACTGGGAGAGGAGCAGAGAAAGGAGGCGGAGAGGAAGCTGGA
AGAGCAACAGCGCCGGCACCGCGAGCACCCTAAAGTCAACGTGCCTGGCAGCCAAGCCCAGTTGAAGGAGGTGTGGGAGGAGCTGGATGG
ACTGGACCCCAACAGGTTTAACCCCAAGACCTTCTTCATACTGCATGATATCAACAGTGATGGTGTCCTGGATGAGCAGGAGCTGGAGGC
ACTCTTCACCAAGGAGCTGGAGAAAGTGTACGACCCAAAGAATGAGGAGGACGACATGCGGGAGATGGAGGAGGAGCGACTGCGCATGCG
GGAGCATGTGATGAAGAATGTGGACACCAACCAGGACCGCCTCGTGACCCTGGAGGAGTTCCTCGCATCCACTCAGAGGAAGGAGTTTGG
GGACACCGGGGAGGGCTGGGAGACAGTGGAGATGCACCCTGCCTACACCGAGGAAGAGCTGAGGCGCTTTGAAGAGGAGCTGGCTGCCCG
GGAGGCAGAGCTGAATGCCAAGGCCCAGCGCCTCAGCCAGGAGACAGAGGCTCTAGGGCGGTCCCAGGGCCGCCTGGAGGCCCAGAAGAG
AGAGCTGCAGCAGGCTGTGCTGCACATGGAGCAGCGGAAGCAGCAGCAGCAGCAGCAGCAAGGCCACAAGGCCCCGGCTGCCCACCCTGA
GGGGCAGCTCAAGTTCCACCCAGACACAGACGATGTACCTGTCCCAGCTCCAGCCGGTGACCAGAAGGAGGTGGACACTTCAGAAAAGAA
ACTTCTCGAGCGGCTCCCTGAGGTTGAGGTGCCCCAGCATCTGTGATCCTCCGGGACCCCAGCCCTCAGGATTCCTGATGCTCCAAGGCG
ACTGATGGGCGCTGGATGAAGTGGCACAGTCAGCTTCCCTGGGGGCTGGTGTCATGTTGGGCTCCTGGGGCGGGGGCACGGCCTGGCATT
TCACGCATTGCTGCCACCCCAGGTCCACCTGTCTCCACTTTCACAGCCTCCAAGTCTGTGGCTCTTCCCTTCTGTCCTCCGAGGGGCTTG
CCTTCTCTCGTGTCCAGTGAGGTGCTCAGTGATCGGCTTAACTTAGAGAAGCCCGCCCCCTCCCCTTCTCCGTCTGTCCCAAGAGGGTCT
GCTCTGAGCCTGCGTTCCTAGGTGGCTCGGCCTCAGCTGCCTGGGTTGTGGCCGCCCTAGCATCCTGTATGCCCACAGCTACTGGAATCC
CCGCTGCTGCTCCGGGCCAAGCTTCTGGTTGATTAATGAGGGCATGGGGTGGTCCCTCAAGACCTTCCCCTACCTTTTGTGGAACCAGTG
ATGCCTCAAAGACAGTGTCCCCTCCACAGCTGGGTGCCAGGGGCAGGGGATCCTCAGTATAGCCGGTGAACCCTGATACCAGGAGCCTGG
GCCTCCCTGAACCCCTGGCTTCCAGCCATCTCATCGCCAGCCTCCTCCTGGACCTCTTGGCCCCCAGCCCCTTCCCCACACAGCCCCAGA
AGGGTCCCAGAGCTGACCCCACTCCAGGACCTAGGCCCAGCCCCTCAGCCTCATCTGGAGCCCCTGAAGACCAGTCCCACCCACCTTTCT
GGCCTCATCTGACACTGCTCCGCATCCTGCTGTGTGTCCTGTTCCATGTTCCGGTTCCATCCAAATACACTTTCTGGAACAAATGCATGG
CTCCATGCCTGTGTATCTGGACTGGTCCCTCCAAAACGCTATTGCCACGTCACCTGCCGGAGTCCTCATCTTTGAAGACTGGATTCAAGC

>44664_44664_5_LIG1-NUCB1_LIG1_chr19_48660270_ENST00000536218_NUCB1_chr19_49414430_ENST00000405315_length(amino acids)=327AA_BP=1
MKQFEHLDPQNQHTFEARDLELLIQTATRDLAQYDAAHHEEFKRYEMLKEHERRRYLESLGEEQRKEAERKLEEQQRRHREHPKVNVPGS
QAQLKEVWEELDGLDPNRFNPKTFFILHDINSDGVLDEQELEALFTKELEKVYDPKNEEDDMREMEEERLRMREHVMKNVDTNQDRLVTL
EEFLASTQRKEFGDTGEGWETVEMHPAYTEEELRRFEEELAAREAELNAKAQRLSQETEALGRSQGRLEAQKRELQQAVLHMEQRKQQQQ

--------------------------------------------------------------
>44664_44664_6_LIG1-NUCB1_LIG1_chr19_48660270_ENST00000536218_NUCB1_chr19_49414430_ENST00000407032_length(transcript)=2194nt_BP=501nt
ACTTGGGACTGCAGAGGCGCGCCTGGCGGATCTGAGTGTGTTGCCCGGGCAGCGGCGCGCGGGACCAACGCAAGGAGCAGCTGACAGACG
AAGAAAAGTGCTGGACAGGAAGGGAGAATTCTGACGCCAACATGCAGCGAAGTATCATGTCATTTTTCCACCCCAAGAAAGAGGGTAAAG
CAAAGAAGCCTGAGAAGGAGGCATCCAATAGCAGCAGAGAGACGGAGCCCCCTCCAAAGGCGGCACTGAAGGAGTGGAATGGAGTGGTGT
CCGAGAGTGACTCTCCGGTGAAGAGGCCAGGGAGGAAGGCGGCCCGGGTCCTGGGCAGCGAAGGGGAAGAGGAGGATGAAGCCCTTAGCC
CTGCTAAAGGCCAGAAGCCTGCCCTGGACTGCTCACAGGTCTCCCCGCCCCGTCCTGCCACATCTCCTGAGAACAATGCTTCCCTCTCTG
ACACCTCTCCCATGGACAGTTCCCCATCAGGGATTCCGAAGCGTCGCACAGCCTGAAACAGTTTGAACACCTGGACCCTCAGAACCAGCA
TACATTCGAGGCCCGCGACCTGGAGCTGCTGATCCAGACGGCCACCCGGGACCTTGCCCAGTACGACGCAGCCCATCATGAAGAGTTCAA
GCGCTACGAGATGCTTAAGGAACACGAGAGACGGCGTTATCTGGAGTCACTGGGAGAGGAGCAGAGAAAGGAGGCGGAGAGGAAGCTGGA
AGAGCAACAGCGCCGGCACCGCGAGCACCCTAAAGTCAACGTGCCTGGCAGCCAAGCCCAGTTGAAGGAGGTGTGGGAGGAGCTGGATGG
ACTGGACCCCAACAGGTTTAACCCCAAGACCTTCTTCATACTGCATGATATCAACAGTGATGGTGTCCTGGATGAGCAGGAGCTGGAGGC
ACTCTTCACCAAGGAGCTGGAGAAAGTGTACGACCCAAAGAATGAGGAGGACGACATGCGGGAGATGGAGGAGGAGCGACTGCGCATGCG
GGAGCATGTGATGAAGAATGTGGACACCAACCAGGACCGCCTCGTGACCCTGGAGGAGTTCCTCGCATCCACTCAGAGGAAGGAGTTTGG
GGACACCGGGGAGGGCTGGGAGACAGTGGAGATGCACCCTGCCTACACCGAGGAAGAGCTGAGGCGCTTTGAAGAGGAGCTGGCTGCCCG
GGAGGCAGAGCTGAATGCCAAGGCCCAGCGCCTCAGCCAGGAGACAGAGGCTCTAGGGCGGTCCCAGGGCCGCCTGGAGGCCCAGAAGAG
AGAGCTGCAGCAGGCTGTGCTGCACATGGAGCAGCGGAAGCAGCAGCAGCAGCAGCAGCAAGGCCACAAGGCCCCGGCTGCCCACCCTGA
GGGGCAGCTCAAGTTCCACCCAGACACAGACGATGTACCTGTCCCAGCTCCAGCCGGTGACCAGAAGGAGGTGGACACTTCAGAAAAGAA
ACTTCTCGAGCGGCTCCCTGAGGTTGAGGTGCCCCAGCATCTGTGATCCTCCGGGACCCCAGCCCTCAGGATTCCTGATGCTCCAAGCCT
CCAAGTCTGTGGCTCTTCCCTTCTGTCCTCCGAGGGGCTTGCCTTCTCTCGTGTCCAGTGAGGTGCTCAGTGATCGGCTTAACTTAGAGA
AGCCCGCCCCCTCCCCTTCTCCGTCTGTCCCAAGAGGGTCTGCTCTGAGCCTGCGTTCCTAGGTGGCTCGGCCTCAGCTGCCTGGGTTGT
GGCCGCCCTAGCATCCTGTATGCCCACAGCTACTGGAATCCCCGCTGCTGCTCCGGGCCAAGCTTCTGGTTGATTAATGAGGGCATGGGG
TGGTCCCTCAAGACCTTCCCCTACCTTTTGTGGAACCAGTGATGCCTCAAAGACAGTGTCCCCTCCACAGCTGGGTGCCAGGGGCAGGGG
ATCCTCAGTATAGCCGGTGAACCCTGATACCAGGAGCCTGGGCCTCCCTGAACCCCTGGCTTCCAGCCATCTCATCGCCAGCCTCCTCCT
GGACCTCTTGGCCCCCAGCCCCTTCCCCACACAGCCCCAGAAGGGTCCCAGAGCTGACCCCACTCCAGGACCTAGGCCCAGCCCCTCAGC
CTCATCTGGAGCCCCTGAAGACCAGTCCCACCCACCTTTCTGGCCTCATCTGACACTGCTCCGCATCCTGCTGTGTGTCCTGTTCCATGT

>44664_44664_6_LIG1-NUCB1_LIG1_chr19_48660270_ENST00000536218_NUCB1_chr19_49414430_ENST00000407032_length(amino acids)=327AA_BP=1
MKQFEHLDPQNQHTFEARDLELLIQTATRDLAQYDAAHHEEFKRYEMLKEHERRRYLESLGEEQRKEAERKLEEQQRRHREHPKVNVPGS
QAQLKEVWEELDGLDPNRFNPKTFFILHDINSDGVLDEQELEALFTKELEKVYDPKNEEDDMREMEEERLRMREHVMKNVDTNQDRLVTL
EEFLASTQRKEFGDTGEGWETVEMHPAYTEEELRRFEEELAAREAELNAKAQRLSQETEALGRSQGRLEAQKRELQQAVLHMEQRKQQQQ

--------------------------------------------------------------

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Fusion Gene PPI Analysis for LIG1-NUCB1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneLIG1chr19:48660270chr19:49414430ENST00000263274-528449_458123.33333333333333920.0target DNA
HgeneLIG1chr19:48660270chr19:49414430ENST00000263274-528642_644123.33333333333333920.0target DNA


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for LIG1-NUCB1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for LIG1-NUCB1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource