FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:LIG3-ZFAT (FusionGDB2 ID:44674)

Fusion Gene Summary for LIG3-ZFAT

check button Fusion gene summary
Fusion gene informationFusion gene name: LIG3-ZFAT
Fusion gene ID: 44674
HgeneTgene
Gene symbol

LIG3

ZFAT

Gene ID

121227

57623

Gene nameleucine rich repeats and immunoglobulin like domains 3zinc finger and AT-hook domain containing
SynonymsLIG3AITD3|ZFAT1|ZNF406
Cytomap

12q14.1

8q24.22

Type of geneprotein-codingprotein-coding
Descriptionleucine-rich repeats and immunoglobulin-like domains protein 3LIG-3zinc finger protein ZFATzinc finger gene in autoimmune thyroid diseasezinc finger protein 406zinc-finger gene in AITD susceptibility region
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000262327, ENST00000378526, 
ENST00000586407, 		ENST00000377838, 
ENST00000429442, ENST00000517307, 
ENST00000520214, ENST00000523399, 
ENST00000520356, ENST00000520727, 
Fusion gene scores* DoF score8 X 10 X 2=1607 X 7 X 6=294
# samples 87
** MAII scorelog2(8/160*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/294*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: LIG3 [Title/Abstract] AND ZFAT [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointLIG3(33321450)-ZFAT(135490964), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across LIG3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ZFAT (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-E9-A1RF-01ALIG3chr17

33321450

-ZFATchr8

135490964

-
ChimerDB4BRCATCGA-E9-A1RF-01ALIG3chr17

33321450

+ZFATchr8

135490964

-


Top

Fusion Gene ORF analysis for LIG3-ZFAT

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000262327ENST00000377838LIG3chr17

33321450

+ZFATchr8

135490964

-
5CDS-intronENST00000262327ENST00000429442LIG3chr17

33321450

+ZFATchr8

135490964

-
5CDS-intronENST00000262327ENST00000517307LIG3chr17

33321450

+ZFATchr8

135490964

-
5CDS-intronENST00000262327ENST00000520214LIG3chr17

33321450

+ZFATchr8

135490964

-
5CDS-intronENST00000262327ENST00000523399LIG3chr17

33321450

+ZFATchr8

135490964

-
5CDS-intronENST00000378526ENST00000377838LIG3chr17

33321450

+ZFATchr8

135490964

-
5CDS-intronENST00000378526ENST00000429442LIG3chr17

33321450

+ZFATchr8

135490964

-
5CDS-intronENST00000378526ENST00000517307LIG3chr17

33321450

+ZFATchr8

135490964

-
5CDS-intronENST00000378526ENST00000520214LIG3chr17

33321450

+ZFATchr8

135490964

-
5CDS-intronENST00000378526ENST00000523399LIG3chr17

33321450

+ZFATchr8

135490964

-
In-frameENST00000262327ENST00000520356LIG3chr17

33321450

+ZFATchr8

135490964

-
In-frameENST00000262327ENST00000520727LIG3chr17

33321450

+ZFATchr8

135490964

-
In-frameENST00000378526ENST00000520356LIG3chr17

33321450

+ZFATchr8

135490964

-
In-frameENST00000378526ENST00000520727LIG3chr17

33321450

+ZFATchr8

135490964

-
intron-3CDSENST00000586407ENST00000520356LIG3chr17

33321450

+ZFATchr8

135490964

-
intron-3CDSENST00000586407ENST00000520727LIG3chr17

33321450

+ZFATchr8

135490964

-
intron-intronENST00000586407ENST00000377838LIG3chr17

33321450

+ZFATchr8

135490964

-
intron-intronENST00000586407ENST00000429442LIG3chr17

33321450

+ZFATchr8

135490964

-
intron-intronENST00000586407ENST00000517307LIG3chr17

33321450

+ZFATchr8

135490964

-
intron-intronENST00000586407ENST00000520214LIG3chr17

33321450

+ZFATchr8

135490964

-
intron-intronENST00000586407ENST00000523399LIG3chr17

33321450

+ZFATchr8

135490964

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000378526LIG3chr1733321450+ENST00000520356ZFATchr8135490964-267817441331983616
ENST00000378526LIG3chr1733321450+ENST00000520727ZFATchr8135490964-267417441331983616
ENST00000262327LIG3chr1733321450+ENST00000520356ZFATchr8135490964-26261692811931616
ENST00000262327LIG3chr1733321450+ENST00000520727ZFATchr8135490964-26221692811931616

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000378526ENST00000520356LIG3chr1733321450+ZFATchr8135490964-0.0049826240.99501735
ENST00000378526ENST00000520727LIG3chr1733321450+ZFATchr8135490964-0.0049539550.995046
ENST00000262327ENST00000520356LIG3chr1733321450+ZFATchr8135490964-0.0052170270.994783
ENST00000262327ENST00000520727LIG3chr1733321450+ZFATchr8135490964-0.0051905850.9948094

Top

Fusion Genomic Features for LIG3-ZFAT


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for LIG3-ZFAT


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:33321450/chr8:135490964)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLIG3chr17:33321450chr8:135490964ENST00000262327+92093_185537950.0Zinc fingerPARP-type
HgeneLIG3chr17:33321450chr8:135490964ENST00000378526+92093_1855371010.0Zinc fingerPARP-type

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneZFATchr17:33321450chr8:135490964ENST0000037783814161041_106411641244.0Zinc fingerC2H2-type 19
TgeneZFATchr17:33321450chr8:135490964ENST000003778381416116_14111641244.0Zinc fingerC2H2-type 2%3B degenerate
TgeneZFATchr17:33321450chr8:135490964ENST00000377838141612_3511641244.0Zinc fingerC2H2-type 1
TgeneZFATchr17:33321450chr8:135490964ENST000003778381416271_29311641244.0Zinc fingerC2H2-type 3
TgeneZFATchr17:33321450chr8:135490964ENST000003778381416299_32111641244.0Zinc fingerC2H2-type 4
TgeneZFATchr17:33321450chr8:135490964ENST000003778381416326_34911641244.0Zinc fingerC2H2-type 5
TgeneZFATchr17:33321450chr8:135490964ENST000003778381416354_37711641244.0Zinc fingerC2H2-type 6
TgeneZFATchr17:33321450chr8:135490964ENST000003778381416404_42611641244.0Zinc fingerC2H2-type 7
TgeneZFATchr17:33321450chr8:135490964ENST000003778381416432_45411641244.0Zinc fingerC2H2-type 8
TgeneZFATchr17:33321450chr8:135490964ENST000003778381416458_48111641244.0Zinc fingerC2H2-type 9
TgeneZFATchr17:33321450chr8:135490964ENST000003778381416742_76411641244.0Zinc fingerC2H2-type 10
TgeneZFATchr17:33321450chr8:135490964ENST000003778381416770_79311641244.0Zinc fingerC2H2-type 11
TgeneZFATchr17:33321450chr8:135490964ENST000003778381416798_82211641244.0Zinc fingerC2H2-type 12
TgeneZFATchr17:33321450chr8:135490964ENST000003778381416830_85311641244.0Zinc fingerC2H2-type 13
TgeneZFATchr17:33321450chr8:135490964ENST000003778381416880_90311641244.0Zinc fingerC2H2-type 14%3B degenerate
TgeneZFATchr17:33321450chr8:135490964ENST000003778381416909_93111641244.0Zinc fingerC2H2-type 15
TgeneZFATchr17:33321450chr8:135490964ENST000003778381416937_95911641244.0Zinc fingerC2H2-type 16
TgeneZFATchr17:33321450chr8:135490964ENST000003778381416966_98811641244.0Zinc fingerC2H2-type 17
TgeneZFATchr17:33321450chr8:135490964ENST000003778381416994_101711641244.0Zinc fingerC2H2-type 18
TgeneZFATchr17:33321450chr8:135490964ENST0000052021414161041_106411521232.0Zinc fingerC2H2-type 19
TgeneZFATchr17:33321450chr8:135490964ENST000005202141416116_14111521232.0Zinc fingerC2H2-type 2%3B degenerate
TgeneZFATchr17:33321450chr8:135490964ENST00000520214141612_3511521232.0Zinc fingerC2H2-type 1
TgeneZFATchr17:33321450chr8:135490964ENST000005202141416271_29311521232.0Zinc fingerC2H2-type 3
TgeneZFATchr17:33321450chr8:135490964ENST000005202141416299_32111521232.0Zinc fingerC2H2-type 4
TgeneZFATchr17:33321450chr8:135490964ENST000005202141416326_34911521232.0Zinc fingerC2H2-type 5
TgeneZFATchr17:33321450chr8:135490964ENST000005202141416354_37711521232.0Zinc fingerC2H2-type 6
TgeneZFATchr17:33321450chr8:135490964ENST000005202141416404_42611521232.0Zinc fingerC2H2-type 7
TgeneZFATchr17:33321450chr8:135490964ENST000005202141416432_45411521232.0Zinc fingerC2H2-type 8
TgeneZFATchr17:33321450chr8:135490964ENST000005202141416458_48111521232.0Zinc fingerC2H2-type 9
TgeneZFATchr17:33321450chr8:135490964ENST000005202141416742_76411521232.0Zinc fingerC2H2-type 10
TgeneZFATchr17:33321450chr8:135490964ENST000005202141416770_79311521232.0Zinc fingerC2H2-type 11
TgeneZFATchr17:33321450chr8:135490964ENST000005202141416798_82211521232.0Zinc fingerC2H2-type 12
TgeneZFATchr17:33321450chr8:135490964ENST000005202141416830_85311521232.0Zinc fingerC2H2-type 13
TgeneZFATchr17:33321450chr8:135490964ENST000005202141416880_90311521232.0Zinc fingerC2H2-type 14%3B degenerate
TgeneZFATchr17:33321450chr8:135490964ENST000005202141416909_93111521232.0Zinc fingerC2H2-type 15
TgeneZFATchr17:33321450chr8:135490964ENST000005202141416937_95911521232.0Zinc fingerC2H2-type 16
TgeneZFATchr17:33321450chr8:135490964ENST000005202141416966_98811521232.0Zinc fingerC2H2-type 17
TgeneZFATchr17:33321450chr8:135490964ENST000005202141416994_101711521232.0Zinc fingerC2H2-type 18
TgeneZFATchr17:33321450chr8:135490964ENST0000052072715171041_106411521232.0Zinc fingerC2H2-type 19
TgeneZFATchr17:33321450chr8:135490964ENST000005207271517116_14111521232.0Zinc fingerC2H2-type 2%3B degenerate
TgeneZFATchr17:33321450chr8:135490964ENST00000520727151712_3511521232.0Zinc fingerC2H2-type 1
TgeneZFATchr17:33321450chr8:135490964ENST000005207271517271_29311521232.0Zinc fingerC2H2-type 3
TgeneZFATchr17:33321450chr8:135490964ENST000005207271517299_32111521232.0Zinc fingerC2H2-type 4
TgeneZFATchr17:33321450chr8:135490964ENST000005207271517326_34911521232.0Zinc fingerC2H2-type 5
TgeneZFATchr17:33321450chr8:135490964ENST000005207271517354_37711521232.0Zinc fingerC2H2-type 6
TgeneZFATchr17:33321450chr8:135490964ENST000005207271517404_42611521232.0Zinc fingerC2H2-type 7
TgeneZFATchr17:33321450chr8:135490964ENST000005207271517432_45411521232.0Zinc fingerC2H2-type 8
TgeneZFATchr17:33321450chr8:135490964ENST000005207271517458_48111521232.0Zinc fingerC2H2-type 9
TgeneZFATchr17:33321450chr8:135490964ENST000005207271517742_76411521232.0Zinc fingerC2H2-type 10
TgeneZFATchr17:33321450chr8:135490964ENST000005207271517770_79311521232.0Zinc fingerC2H2-type 11
TgeneZFATchr17:33321450chr8:135490964ENST000005207271517798_82211521232.0Zinc fingerC2H2-type 12
TgeneZFATchr17:33321450chr8:135490964ENST000005207271517830_85311521232.0Zinc fingerC2H2-type 13
TgeneZFATchr17:33321450chr8:135490964ENST000005207271517880_90311521232.0Zinc fingerC2H2-type 14%3B degenerate
TgeneZFATchr17:33321450chr8:135490964ENST000005207271517909_93111521232.0Zinc fingerC2H2-type 15
TgeneZFATchr17:33321450chr8:135490964ENST000005207271517937_95911521232.0Zinc fingerC2H2-type 16
TgeneZFATchr17:33321450chr8:135490964ENST000005207271517966_98811521232.0Zinc fingerC2H2-type 17
TgeneZFATchr17:33321450chr8:135490964ENST000005207271517994_101711521232.0Zinc fingerC2H2-type 18
TgeneZFATchr17:33321450chr8:135490964ENST0000052339913151041_106411021182.0Zinc fingerC2H2-type 19
TgeneZFATchr17:33321450chr8:135490964ENST000005233991315116_14111021182.0Zinc fingerC2H2-type 2%3B degenerate
TgeneZFATchr17:33321450chr8:135490964ENST00000523399131512_3511021182.0Zinc fingerC2H2-type 1
TgeneZFATchr17:33321450chr8:135490964ENST000005233991315271_29311021182.0Zinc fingerC2H2-type 3
TgeneZFATchr17:33321450chr8:135490964ENST000005233991315299_32111021182.0Zinc fingerC2H2-type 4
TgeneZFATchr17:33321450chr8:135490964ENST000005233991315326_34911021182.0Zinc fingerC2H2-type 5
TgeneZFATchr17:33321450chr8:135490964ENST000005233991315354_37711021182.0Zinc fingerC2H2-type 6
TgeneZFATchr17:33321450chr8:135490964ENST000005233991315404_42611021182.0Zinc fingerC2H2-type 7
TgeneZFATchr17:33321450chr8:135490964ENST000005233991315432_45411021182.0Zinc fingerC2H2-type 8
TgeneZFATchr17:33321450chr8:135490964ENST000005233991315458_48111021182.0Zinc fingerC2H2-type 9
TgeneZFATchr17:33321450chr8:135490964ENST000005233991315742_76411021182.0Zinc fingerC2H2-type 10
TgeneZFATchr17:33321450chr8:135490964ENST000005233991315770_79311021182.0Zinc fingerC2H2-type 11
TgeneZFATchr17:33321450chr8:135490964ENST000005233991315798_82211021182.0Zinc fingerC2H2-type 12
TgeneZFATchr17:33321450chr8:135490964ENST000005233991315830_85311021182.0Zinc fingerC2H2-type 13
TgeneZFATchr17:33321450chr8:135490964ENST000005233991315880_90311021182.0Zinc fingerC2H2-type 14%3B degenerate
TgeneZFATchr17:33321450chr8:135490964ENST000005233991315909_93111021182.0Zinc fingerC2H2-type 15
TgeneZFATchr17:33321450chr8:135490964ENST000005233991315937_95911021182.0Zinc fingerC2H2-type 16
TgeneZFATchr17:33321450chr8:135490964ENST000005233991315966_98811021182.0Zinc fingerC2H2-type 17
TgeneZFATchr17:33321450chr8:135490964ENST000005233991315994_101711021182.0Zinc fingerC2H2-type 18


Top

Fusion Gene Sequence for LIG3-ZFAT


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>44674_44674_1_LIG3-ZFAT_LIG3_chr17_33321450_ENST00000262327_ZFAT_chr8_135490964_ENST00000520356_length(transcript)=2626nt_BP=1692nt
CAACCGTCGTGGGCTGCCCGCGGCCTGTAATGAGCAAGTTCCGAGGCCTACGGTGAGCGCCGGAGCCGGAGAGGCAGCTATATGTCTTTG
GCTTTCAAGATCTTCTTTCCACAAACCCTCCGTGCACTCAGCCGAAAAGAACTGTGCCTATTCCGAAAACATCACTGGCGTGATGTAAGA
CAATTCAGCCAGTGGTCAGAAACAGATCTGCTTCATGGACATCCCCTCTTCCTGAGAAGAAAGCCTGTTCTATCATTCCAGGGAAGCCAT
CTAAGATCACGTGCCACCTACCTTGTTTTCTTGCCAGGGTTGCATGTGGGACTCTGCAGTGGCCCCTGTGAGATGGCTGAGCAACGGTTC
TGTGTGGACTATGCCAAGCGTGGCACAGCTGGCTGCAAAAAATGCAAGGAAAAGATTGTGAAGGGCGTATGCCGAATTGGCAAAGTGGTG
CCCAATCCCTTCTCAGAGTCTGGGGGTGATATGAAAGAGTGGTACCACATTAAATGCATGTTTGAGAAACTAGAGCGGGCCCGGGCCACC
ACAAAAAAAATCGAGGACCTCACAGAGCTGGAAGGCTGGGAAGAGCTGGAAGATAATGAGAAGGAACAGATAACCCAGCACATTGCAGAT
CTGTCTTCTAAGGCAGCAGGTACACCAAAGAAGAAAGCTGTTGTCCAGGCTAAGTTGACAACCACTGGCCAGGTGACTTCTCCAGTGAAA
GGCGCCTCATTTGTCACCAGTACCAATCCCCGGAAATTTTCTGGCTTTTCAGCCAAGCCCAACAACTCTGGGGAAGCCCCCTCGAGCCCC
ACCCCTAAGAGAAGTCTGTCTTCAAGCAAATGTGACCCCAGGCATAAGGACTGTCTGCTACGGGAGTTTCGAAAGTTATGCGCCATGGTG
GCCGATAATCCTAGCTACAACACGAAGACCCAGATCATCCAGGACTTCCTTCGGAAAGGCTCAGCAGGAGATGGTTTCCACGGTGATGTG
TACCTAACAGTGAAGCTGCTGCTGCCAGGAGTCATTAAGACTGTTTACAACTTGAACGATAAGCAGATTGTGAAGCTTTTCAGTCGCATT
TTTAACTGCAACCCAGATGATATGGCACGGGACCTAGAGCAGGGTGACGTGTCAGAGACAATCAGAGTCTTCTTTGAGCAGAGCAAGTCT
TTCCCCCCAGCTGCCAAGAGCCTCCTTACCATCCAGGAAGTGGATGAGTTCCTTCTGCGGCTGTCCAAGCTCACCAAGGAGGATGAGCAG
CAACAGGCCCTACAGGACATTGCCTCCAGGTGTACAGCCAATGACCTTAAATGCATCATCAGGTTGATCAAACATGATCTGAAGATGAAC
TCAGGTGCAAAACATGTGTTAGACGCCCTTGACCCCAATGCCTATGAAGCCTTCAAAGCCTCGCGCAACCTGCAGGATGTGGTGGAGCGG
GTCCTTCACAACGCGCAGGAGGTGGAGAAGGAGCCGGGCCAGAGACGAGCTCTGAGCGTCCAGGCCTCGCTGATGACACCTGTGCAGCCC
ATGTTGGCGGAGGCCTGCAAGTCCGTTGAGTATGCAATGAAGAAATGTCCCAATGGCATGTTCTCTGAGATCAAGTACGATGGAGAGCGA
GTCCAGGTGCATAAGAATGGAGACCACTTCAGCTACTTCAGCCGCAGTCTCAAGCCCGTCCTTCCTCACAAGGTCACCGAGGAGGAGCCC
AGCTCCAACCACACGGTCATGATCCAGGAGACGGTCCAGCAAGCGTCCGTGGAGCTTGCCGAGCAGCACCACCTGGTGGTGTCCTCCGAC
GACGTGGAGGGCATTGAGACGGTGACTGTCTACACGCAGGGCGGGGAGGCCTCGGAGTTCATCGTCTACGTGCAGGAGGCCATGCAGCCT
GTGGAGGAGCAGGCTGTGGAGCAGCCGGCCCAGGAACTCTAGAGGACATGTGGCATCGGATGGCCACAGGGCGGGGCTGCCAGGCTCTGC
AGGCACCCAGGGTGGGGAGGCCACCCTTCCTGCCCTACCCGCAGAATGGTGCTCTCCTTTGCCCTCCCTGCCCAGCAGCCTGATAGGACT
CTCCTAGTCCAACTTGGGGTGGGCAAGGCAGTCAGCATCACCAGCAATACCACAGGACCCTCACCCCAGCATAGACACACACCCCCTGAC
CCTTACCATCTGCTTCCTGAAAGACTTCAGTGTCAGCTCCCCTACACACACCCCACACCTTCACCCCTTGCTTCAAGATTCAAACAGAGA
CTCCCAGTCCCCCTCAGCATCTTCCCTGAATCACAGCCCCAGCTCCTTGACCCCCATCTAGGTGCCAAATGTTCATCTGCAACCGCTATG
CAGTCTGGTGAGAGGGAGACAGCCATCACATAGAAAGTGACCGTACGGGTTTTTAATCACTGCTGGGTGGGGTGGGGGTAGGGGGATTGT
CCTGGCTTTGTCGACAAAGTCCCACTTCCCCGAGTATTAAGGGCCCTTGGTATCAAGTGAGGTAAATTCACCCATCACAGGGTCTCGCCC
TACCATCCTGGAATTATTTCACTTTTAAGATAAATGCACTATTTCACTGTTCGCCTCCCATTCTAAGGAGGTGAGGTGGTTGGAATAAAA

>44674_44674_1_LIG3-ZFAT_LIG3_chr17_33321450_ENST00000262327_ZFAT_chr8_135490964_ENST00000520356_length(amino acids)=616AA_BP=537
MSLAFKIFFPQTLRALSRKELCLFRKHHWRDVRQFSQWSETDLLHGHPLFLRRKPVLSFQGSHLRSRATYLVFLPGLHVGLCSGPCEMAE
QRFCVDYAKRGTAGCKKCKEKIVKGVCRIGKVVPNPFSESGGDMKEWYHIKCMFEKLERARATTKKIEDLTELEGWEELEDNEKEQITQH
IADLSSKAAGTPKKKAVVQAKLTTTGQVTSPVKGASFVTSTNPRKFSGFSAKPNNSGEAPSSPTPKRSLSSSKCDPRHKDCLLREFRKLC
AMVADNPSYNTKTQIIQDFLRKGSAGDGFHGDVYLTVKLLLPGVIKTVYNLNDKQIVKLFSRIFNCNPDDMARDLEQGDVSETIRVFFEQ
SKSFPPAAKSLLTIQEVDEFLLRLSKLTKEDEQQQALQDIASRCTANDLKCIIRLIKHDLKMNSGAKHVLDALDPNAYEAFKASRNLQDV
VERVLHNAQEVEKEPGQRRALSVQASLMTPVQPMLAEACKSVEYAMKKCPNGMFSEIKYDGERVQVHKNGDHFSYFSRSLKPVLPHKVTE

--------------------------------------------------------------
>44674_44674_2_LIG3-ZFAT_LIG3_chr17_33321450_ENST00000262327_ZFAT_chr8_135490964_ENST00000520727_length(transcript)=2622nt_BP=1692nt
CAACCGTCGTGGGCTGCCCGCGGCCTGTAATGAGCAAGTTCCGAGGCCTACGGTGAGCGCCGGAGCCGGAGAGGCAGCTATATGTCTTTG
GCTTTCAAGATCTTCTTTCCACAAACCCTCCGTGCACTCAGCCGAAAAGAACTGTGCCTATTCCGAAAACATCACTGGCGTGATGTAAGA
CAATTCAGCCAGTGGTCAGAAACAGATCTGCTTCATGGACATCCCCTCTTCCTGAGAAGAAAGCCTGTTCTATCATTCCAGGGAAGCCAT
CTAAGATCACGTGCCACCTACCTTGTTTTCTTGCCAGGGTTGCATGTGGGACTCTGCAGTGGCCCCTGTGAGATGGCTGAGCAACGGTTC
TGTGTGGACTATGCCAAGCGTGGCACAGCTGGCTGCAAAAAATGCAAGGAAAAGATTGTGAAGGGCGTATGCCGAATTGGCAAAGTGGTG
CCCAATCCCTTCTCAGAGTCTGGGGGTGATATGAAAGAGTGGTACCACATTAAATGCATGTTTGAGAAACTAGAGCGGGCCCGGGCCACC
ACAAAAAAAATCGAGGACCTCACAGAGCTGGAAGGCTGGGAAGAGCTGGAAGATAATGAGAAGGAACAGATAACCCAGCACATTGCAGAT
CTGTCTTCTAAGGCAGCAGGTACACCAAAGAAGAAAGCTGTTGTCCAGGCTAAGTTGACAACCACTGGCCAGGTGACTTCTCCAGTGAAA
GGCGCCTCATTTGTCACCAGTACCAATCCCCGGAAATTTTCTGGCTTTTCAGCCAAGCCCAACAACTCTGGGGAAGCCCCCTCGAGCCCC
ACCCCTAAGAGAAGTCTGTCTTCAAGCAAATGTGACCCCAGGCATAAGGACTGTCTGCTACGGGAGTTTCGAAAGTTATGCGCCATGGTG
GCCGATAATCCTAGCTACAACACGAAGACCCAGATCATCCAGGACTTCCTTCGGAAAGGCTCAGCAGGAGATGGTTTCCACGGTGATGTG
TACCTAACAGTGAAGCTGCTGCTGCCAGGAGTCATTAAGACTGTTTACAACTTGAACGATAAGCAGATTGTGAAGCTTTTCAGTCGCATT
TTTAACTGCAACCCAGATGATATGGCACGGGACCTAGAGCAGGGTGACGTGTCAGAGACAATCAGAGTCTTCTTTGAGCAGAGCAAGTCT
TTCCCCCCAGCTGCCAAGAGCCTCCTTACCATCCAGGAAGTGGATGAGTTCCTTCTGCGGCTGTCCAAGCTCACCAAGGAGGATGAGCAG
CAACAGGCCCTACAGGACATTGCCTCCAGGTGTACAGCCAATGACCTTAAATGCATCATCAGGTTGATCAAACATGATCTGAAGATGAAC
TCAGGTGCAAAACATGTGTTAGACGCCCTTGACCCCAATGCCTATGAAGCCTTCAAAGCCTCGCGCAACCTGCAGGATGTGGTGGAGCGG
GTCCTTCACAACGCGCAGGAGGTGGAGAAGGAGCCGGGCCAGAGACGAGCTCTGAGCGTCCAGGCCTCGCTGATGACACCTGTGCAGCCC
ATGTTGGCGGAGGCCTGCAAGTCCGTTGAGTATGCAATGAAGAAATGTCCCAATGGCATGTTCTCTGAGATCAAGTACGATGGAGAGCGA
GTCCAGGTGCATAAGAATGGAGACCACTTCAGCTACTTCAGCCGCAGTCTCAAGCCCGTCCTTCCTCACAAGGTCACCGAGGAGGAGCCC
AGCTCCAACCACACGGTCATGATCCAGGAGACGGTCCAGCAAGCGTCCGTGGAGCTTGCCGAGCAGCACCACCTGGTGGTGTCCTCCGAC
GACGTGGAGGGCATTGAGACGGTGACTGTCTACACGCAGGGCGGGGAGGCCTCGGAGTTCATCGTCTACGTGCAGGAGGCCATGCAGCCT
GTGGAGGAGCAGGCTGTGGAGCAGCCGGCCCAGGAACTCTAGAGGACATGTGGCATCGGATGGCCACAGGGCGGGGCTGCCAGGCTCTGC
AGGCACCCAGGGTGGGGAGGCCACCCTTCCTGCCCTACCCGCAGAATGGTGCTCTCCTTTGCCCTCCCTGCCCAGCAGCCTGATAGGACT
CTCCTAGTCCAACTTGGGGTGGGCAAGGCAGTCAGCATCACCAGCAATACCACAGGACCCTCACCCCAGCATAGACACACACCCCCTGAC
CCTTACCATCTGCTTCCTGAAAGACTTCAGTGTCAGCTCCCCTACACACACCCCACACCTTCACCCCTTGCTTCAAGATTCAAACAGAGA
CTCCCAGTCCCCCTCAGCATCTTCCCTGAATCACAGCCCCAGCTCCTTGACCCCCATCTAGGTGCCAAATGTTCATCTGCAACCGCTATG
CAGTCTGGTGAGAGGGAGACAGCCATCACATAGAAAGTGACCGTACGGGTTTTTAATCACTGCTGGGTGGGGTGGGGGTAGGGGGATTGT
CCTGGCTTTGTCGACAAAGTCCCACTTCCCCGAGTATTAAGGGCCCTTGGTATCAAGTGAGGTAAATTCACCCATCACAGGGTCTCGCCC
TACCATCCTGGAATTATTTCACTTTTAAGATAAATGCACTATTTCACTGTTCGCCTCCCATTCTAAGGAGGTGAGGTGGTTGGAATAAAA

>44674_44674_2_LIG3-ZFAT_LIG3_chr17_33321450_ENST00000262327_ZFAT_chr8_135490964_ENST00000520727_length(amino acids)=616AA_BP=537
MSLAFKIFFPQTLRALSRKELCLFRKHHWRDVRQFSQWSETDLLHGHPLFLRRKPVLSFQGSHLRSRATYLVFLPGLHVGLCSGPCEMAE
QRFCVDYAKRGTAGCKKCKEKIVKGVCRIGKVVPNPFSESGGDMKEWYHIKCMFEKLERARATTKKIEDLTELEGWEELEDNEKEQITQH
IADLSSKAAGTPKKKAVVQAKLTTTGQVTSPVKGASFVTSTNPRKFSGFSAKPNNSGEAPSSPTPKRSLSSSKCDPRHKDCLLREFRKLC
AMVADNPSYNTKTQIIQDFLRKGSAGDGFHGDVYLTVKLLLPGVIKTVYNLNDKQIVKLFSRIFNCNPDDMARDLEQGDVSETIRVFFEQ
SKSFPPAAKSLLTIQEVDEFLLRLSKLTKEDEQQQALQDIASRCTANDLKCIIRLIKHDLKMNSGAKHVLDALDPNAYEAFKASRNLQDV
VERVLHNAQEVEKEPGQRRALSVQASLMTPVQPMLAEACKSVEYAMKKCPNGMFSEIKYDGERVQVHKNGDHFSYFSRSLKPVLPHKVTE

--------------------------------------------------------------
>44674_44674_3_LIG3-ZFAT_LIG3_chr17_33321450_ENST00000378526_ZFAT_chr8_135490964_ENST00000520356_length(transcript)=2678nt_BP=1744nt
GCCTGCGCGCTGCCTCCCGCTCTAGGACCCGGATTTAAAGAGACAGGCGCTCCAACCGTCGTGGGCTGCCCGCGGCCTGTAATGAGCAAG
TTCCGAGGCCTACGGTGAGCGCCGGAGCCGGAGAGGCAGCTATATGTCTTTGGCTTTCAAGATCTTCTTTCCACAAACCCTCCGTGCACT
CAGCCGAAAAGAACTGTGCCTATTCCGAAAACATCACTGGCGTGATGTAAGACAATTCAGCCAGTGGTCAGAAACAGATCTGCTTCATGG
ACATCCCCTCTTCCTGAGAAGAAAGCCTGTTCTATCATTCCAGGGAAGCCATCTAAGATCACGTGCCACCTACCTTGTTTTCTTGCCAGG
GTTGCATGTGGGACTCTGCAGTGGCCCCTGTGAGATGGCTGAGCAACGGTTCTGTGTGGACTATGCCAAGCGTGGCACAGCTGGCTGCAA
AAAATGCAAGGAAAAGATTGTGAAGGGCGTATGCCGAATTGGCAAAGTGGTGCCCAATCCCTTCTCAGAGTCTGGGGGTGATATGAAAGA
GTGGTACCACATTAAATGCATGTTTGAGAAACTAGAGCGGGCCCGGGCCACCACAAAAAAAATCGAGGACCTCACAGAGCTGGAAGGCTG
GGAAGAGCTGGAAGATAATGAGAAGGAACAGATAACCCAGCACATTGCAGATCTGTCTTCTAAGGCAGCAGGTACACCAAAGAAGAAAGC
TGTTGTCCAGGCTAAGTTGACAACCACTGGCCAGGTGACTTCTCCAGTGAAAGGCGCCTCATTTGTCACCAGTACCAATCCCCGGAAATT
TTCTGGCTTTTCAGCCAAGCCCAACAACTCTGGGGAAGCCCCCTCGAGCCCCACCCCTAAGAGAAGTCTGTCTTCAAGCAAATGTGACCC
CAGGCATAAGGACTGTCTGCTACGGGAGTTTCGAAAGTTATGCGCCATGGTGGCCGATAATCCTAGCTACAACACGAAGACCCAGATCAT
CCAGGACTTCCTTCGGAAAGGCTCAGCAGGAGATGGTTTCCACGGTGATGTGTACCTAACAGTGAAGCTGCTGCTGCCAGGAGTCATTAA
GACTGTTTACAACTTGAACGATAAGCAGATTGTGAAGCTTTTCAGTCGCATTTTTAACTGCAACCCAGATGATATGGCACGGGACCTAGA
GCAGGGTGACGTGTCAGAGACAATCAGAGTCTTCTTTGAGCAGAGCAAGTCTTTCCCCCCAGCTGCCAAGAGCCTCCTTACCATCCAGGA
AGTGGATGAGTTCCTTCTGCGGCTGTCCAAGCTCACCAAGGAGGATGAGCAGCAACAGGCCCTACAGGACATTGCCTCCAGGTGTACAGC
CAATGACCTTAAATGCATCATCAGGTTGATCAAACATGATCTGAAGATGAACTCAGGTGCAAAACATGTGTTAGACGCCCTTGACCCCAA
TGCCTATGAAGCCTTCAAAGCCTCGCGCAACCTGCAGGATGTGGTGGAGCGGGTCCTTCACAACGCGCAGGAGGTGGAGAAGGAGCCGGG
CCAGAGACGAGCTCTGAGCGTCCAGGCCTCGCTGATGACACCTGTGCAGCCCATGTTGGCGGAGGCCTGCAAGTCCGTTGAGTATGCAAT
GAAGAAATGTCCCAATGGCATGTTCTCTGAGATCAAGTACGATGGAGAGCGAGTCCAGGTGCATAAGAATGGAGACCACTTCAGCTACTT
CAGCCGCAGTCTCAAGCCCGTCCTTCCTCACAAGGTCACCGAGGAGGAGCCCAGCTCCAACCACACGGTCATGATCCAGGAGACGGTCCA
GCAAGCGTCCGTGGAGCTTGCCGAGCAGCACCACCTGGTGGTGTCCTCCGACGACGTGGAGGGCATTGAGACGGTGACTGTCTACACGCA
GGGCGGGGAGGCCTCGGAGTTCATCGTCTACGTGCAGGAGGCCATGCAGCCTGTGGAGGAGCAGGCTGTGGAGCAGCCGGCCCAGGAACT
CTAGAGGACATGTGGCATCGGATGGCCACAGGGCGGGGCTGCCAGGCTCTGCAGGCACCCAGGGTGGGGAGGCCACCCTTCCTGCCCTAC
CCGCAGAATGGTGCTCTCCTTTGCCCTCCCTGCCCAGCAGCCTGATAGGACTCTCCTAGTCCAACTTGGGGTGGGCAAGGCAGTCAGCAT
CACCAGCAATACCACAGGACCCTCACCCCAGCATAGACACACACCCCCTGACCCTTACCATCTGCTTCCTGAAAGACTTCAGTGTCAGCT
CCCCTACACACACCCCACACCTTCACCCCTTGCTTCAAGATTCAAACAGAGACTCCCAGTCCCCCTCAGCATCTTCCCTGAATCACAGCC
CCAGCTCCTTGACCCCCATCTAGGTGCCAAATGTTCATCTGCAACCGCTATGCAGTCTGGTGAGAGGGAGACAGCCATCACATAGAAAGT
GACCGTACGGGTTTTTAATCACTGCTGGGTGGGGTGGGGGTAGGGGGATTGTCCTGGCTTTGTCGACAAAGTCCCACTTCCCCGAGTATT
AAGGGCCCTTGGTATCAAGTGAGGTAAATTCACCCATCACAGGGTCTCGCCCTACCATCCTGGAATTATTTCACTTTTAAGATAAATGCA

>44674_44674_3_LIG3-ZFAT_LIG3_chr17_33321450_ENST00000378526_ZFAT_chr8_135490964_ENST00000520356_length(amino acids)=616AA_BP=537
MSLAFKIFFPQTLRALSRKELCLFRKHHWRDVRQFSQWSETDLLHGHPLFLRRKPVLSFQGSHLRSRATYLVFLPGLHVGLCSGPCEMAE
QRFCVDYAKRGTAGCKKCKEKIVKGVCRIGKVVPNPFSESGGDMKEWYHIKCMFEKLERARATTKKIEDLTELEGWEELEDNEKEQITQH
IADLSSKAAGTPKKKAVVQAKLTTTGQVTSPVKGASFVTSTNPRKFSGFSAKPNNSGEAPSSPTPKRSLSSSKCDPRHKDCLLREFRKLC
AMVADNPSYNTKTQIIQDFLRKGSAGDGFHGDVYLTVKLLLPGVIKTVYNLNDKQIVKLFSRIFNCNPDDMARDLEQGDVSETIRVFFEQ
SKSFPPAAKSLLTIQEVDEFLLRLSKLTKEDEQQQALQDIASRCTANDLKCIIRLIKHDLKMNSGAKHVLDALDPNAYEAFKASRNLQDV
VERVLHNAQEVEKEPGQRRALSVQASLMTPVQPMLAEACKSVEYAMKKCPNGMFSEIKYDGERVQVHKNGDHFSYFSRSLKPVLPHKVTE

--------------------------------------------------------------
>44674_44674_4_LIG3-ZFAT_LIG3_chr17_33321450_ENST00000378526_ZFAT_chr8_135490964_ENST00000520727_length(transcript)=2674nt_BP=1744nt
GCCTGCGCGCTGCCTCCCGCTCTAGGACCCGGATTTAAAGAGACAGGCGCTCCAACCGTCGTGGGCTGCCCGCGGCCTGTAATGAGCAAG
TTCCGAGGCCTACGGTGAGCGCCGGAGCCGGAGAGGCAGCTATATGTCTTTGGCTTTCAAGATCTTCTTTCCACAAACCCTCCGTGCACT
CAGCCGAAAAGAACTGTGCCTATTCCGAAAACATCACTGGCGTGATGTAAGACAATTCAGCCAGTGGTCAGAAACAGATCTGCTTCATGG
ACATCCCCTCTTCCTGAGAAGAAAGCCTGTTCTATCATTCCAGGGAAGCCATCTAAGATCACGTGCCACCTACCTTGTTTTCTTGCCAGG
GTTGCATGTGGGACTCTGCAGTGGCCCCTGTGAGATGGCTGAGCAACGGTTCTGTGTGGACTATGCCAAGCGTGGCACAGCTGGCTGCAA
AAAATGCAAGGAAAAGATTGTGAAGGGCGTATGCCGAATTGGCAAAGTGGTGCCCAATCCCTTCTCAGAGTCTGGGGGTGATATGAAAGA
GTGGTACCACATTAAATGCATGTTTGAGAAACTAGAGCGGGCCCGGGCCACCACAAAAAAAATCGAGGACCTCACAGAGCTGGAAGGCTG
GGAAGAGCTGGAAGATAATGAGAAGGAACAGATAACCCAGCACATTGCAGATCTGTCTTCTAAGGCAGCAGGTACACCAAAGAAGAAAGC
TGTTGTCCAGGCTAAGTTGACAACCACTGGCCAGGTGACTTCTCCAGTGAAAGGCGCCTCATTTGTCACCAGTACCAATCCCCGGAAATT
TTCTGGCTTTTCAGCCAAGCCCAACAACTCTGGGGAAGCCCCCTCGAGCCCCACCCCTAAGAGAAGTCTGTCTTCAAGCAAATGTGACCC
CAGGCATAAGGACTGTCTGCTACGGGAGTTTCGAAAGTTATGCGCCATGGTGGCCGATAATCCTAGCTACAACACGAAGACCCAGATCAT
CCAGGACTTCCTTCGGAAAGGCTCAGCAGGAGATGGTTTCCACGGTGATGTGTACCTAACAGTGAAGCTGCTGCTGCCAGGAGTCATTAA
GACTGTTTACAACTTGAACGATAAGCAGATTGTGAAGCTTTTCAGTCGCATTTTTAACTGCAACCCAGATGATATGGCACGGGACCTAGA
GCAGGGTGACGTGTCAGAGACAATCAGAGTCTTCTTTGAGCAGAGCAAGTCTTTCCCCCCAGCTGCCAAGAGCCTCCTTACCATCCAGGA
AGTGGATGAGTTCCTTCTGCGGCTGTCCAAGCTCACCAAGGAGGATGAGCAGCAACAGGCCCTACAGGACATTGCCTCCAGGTGTACAGC
CAATGACCTTAAATGCATCATCAGGTTGATCAAACATGATCTGAAGATGAACTCAGGTGCAAAACATGTGTTAGACGCCCTTGACCCCAA
TGCCTATGAAGCCTTCAAAGCCTCGCGCAACCTGCAGGATGTGGTGGAGCGGGTCCTTCACAACGCGCAGGAGGTGGAGAAGGAGCCGGG
CCAGAGACGAGCTCTGAGCGTCCAGGCCTCGCTGATGACACCTGTGCAGCCCATGTTGGCGGAGGCCTGCAAGTCCGTTGAGTATGCAAT
GAAGAAATGTCCCAATGGCATGTTCTCTGAGATCAAGTACGATGGAGAGCGAGTCCAGGTGCATAAGAATGGAGACCACTTCAGCTACTT
CAGCCGCAGTCTCAAGCCCGTCCTTCCTCACAAGGTCACCGAGGAGGAGCCCAGCTCCAACCACACGGTCATGATCCAGGAGACGGTCCA
GCAAGCGTCCGTGGAGCTTGCCGAGCAGCACCACCTGGTGGTGTCCTCCGACGACGTGGAGGGCATTGAGACGGTGACTGTCTACACGCA
GGGCGGGGAGGCCTCGGAGTTCATCGTCTACGTGCAGGAGGCCATGCAGCCTGTGGAGGAGCAGGCTGTGGAGCAGCCGGCCCAGGAACT
CTAGAGGACATGTGGCATCGGATGGCCACAGGGCGGGGCTGCCAGGCTCTGCAGGCACCCAGGGTGGGGAGGCCACCCTTCCTGCCCTAC
CCGCAGAATGGTGCTCTCCTTTGCCCTCCCTGCCCAGCAGCCTGATAGGACTCTCCTAGTCCAACTTGGGGTGGGCAAGGCAGTCAGCAT
CACCAGCAATACCACAGGACCCTCACCCCAGCATAGACACACACCCCCTGACCCTTACCATCTGCTTCCTGAAAGACTTCAGTGTCAGCT
CCCCTACACACACCCCACACCTTCACCCCTTGCTTCAAGATTCAAACAGAGACTCCCAGTCCCCCTCAGCATCTTCCCTGAATCACAGCC
CCAGCTCCTTGACCCCCATCTAGGTGCCAAATGTTCATCTGCAACCGCTATGCAGTCTGGTGAGAGGGAGACAGCCATCACATAGAAAGT
GACCGTACGGGTTTTTAATCACTGCTGGGTGGGGTGGGGGTAGGGGGATTGTCCTGGCTTTGTCGACAAAGTCCCACTTCCCCGAGTATT
AAGGGCCCTTGGTATCAAGTGAGGTAAATTCACCCATCACAGGGTCTCGCCCTACCATCCTGGAATTATTTCACTTTTAAGATAAATGCA

>44674_44674_4_LIG3-ZFAT_LIG3_chr17_33321450_ENST00000378526_ZFAT_chr8_135490964_ENST00000520727_length(amino acids)=616AA_BP=537
MSLAFKIFFPQTLRALSRKELCLFRKHHWRDVRQFSQWSETDLLHGHPLFLRRKPVLSFQGSHLRSRATYLVFLPGLHVGLCSGPCEMAE
QRFCVDYAKRGTAGCKKCKEKIVKGVCRIGKVVPNPFSESGGDMKEWYHIKCMFEKLERARATTKKIEDLTELEGWEELEDNEKEQITQH
IADLSSKAAGTPKKKAVVQAKLTTTGQVTSPVKGASFVTSTNPRKFSGFSAKPNNSGEAPSSPTPKRSLSSSKCDPRHKDCLLREFRKLC
AMVADNPSYNTKTQIIQDFLRKGSAGDGFHGDVYLTVKLLLPGVIKTVYNLNDKQIVKLFSRIFNCNPDDMARDLEQGDVSETIRVFFEQ
SKSFPPAAKSLLTIQEVDEFLLRLSKLTKEDEQQQALQDIASRCTANDLKCIIRLIKHDLKMNSGAKHVLDALDPNAYEAFKASRNLQDV
VERVLHNAQEVEKEPGQRRALSVQASLMTPVQPMLAEACKSVEYAMKKCPNGMFSEIKYDGERVQVHKNGDHFSYFSRSLKPVLPHKVTE

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for LIG3-ZFAT


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneLIG3chr17:33321450chr8:135490964ENST00000262327+920277_280537.0950.0DNA
HgeneLIG3chr17:33321450chr8:135490964ENST00000262327+920318_323537.0950.0DNA
HgeneLIG3chr17:33321450chr8:135490964ENST00000262327+920388_391537.0950.0DNA
HgeneLIG3chr17:33321450chr8:135490964ENST00000262327+920421_427537.0950.0DNA
HgeneLIG3chr17:33321450chr8:135490964ENST00000378526+920277_280537.01010.0DNA
HgeneLIG3chr17:33321450chr8:135490964ENST00000378526+920318_323537.01010.0DNA
HgeneLIG3chr17:33321450chr8:135490964ENST00000378526+920388_391537.01010.0DNA
HgeneLIG3chr17:33321450chr8:135490964ENST00000378526+920421_427537.01010.0DNA


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for LIG3-ZFAT


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for LIG3-ZFAT


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource