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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:LIMCH1-UCHL1 (FusionGDB2 ID:44706)

Fusion Gene Summary for LIMCH1-UCHL1

Fusion gene summary

Fusion gene information	Fusion gene name: LIMCH1-UCHL1
	Fusion gene ID: 44706
		Hgene	Tgene
	Gene symbol	LIMCH1	UCHL1
	Gene ID	22998	7345
	Gene name	LIM and calponin homology domains 1	ubiquitin C-terminal hydrolase L1
	Synonyms	LIMCH1A\|LMO7B	HEL-117\|HEL-S-53\|NDGOA\|PARK5\|PGP 9.5\|PGP9.5\|PGP95\|SPG79\|Uch-L1
	Cytomap	4p13	4p13
	Type of gene	protein-coding	protein-coding
	Description	LIM and calponin homology domains-containing protein 1	ubiquitin carboxyl-terminal hydrolase isozyme L1epididymis luminal protein 117epididymis secretory protein Li 53neuron cytoplasmic protein 9.5ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)ubiquitin thioesterase L1ubiquitin thioles
	Modification date	20200313	20200329
	UniProtAcc	Q9UPQ0	.
	Ensembl transtripts involved in fusion gene	ENST00000313860, ENST00000508501, ENST00000512632, ENST00000512820, ENST00000512946, ENST00000509638, ENST00000513024, ENST00000381753, ENST00000396595, ENST00000503057, ENST00000509277, ENST00000509454, ENST00000511496, ENST00000514096, ENST00000515785,	ENST00000284440, ENST00000503431, ENST00000504818, ENST00000508768, ENST00000512788,
Fusion gene scores	* DoF score	14 X 12 X 9=1512	4 X 7 X 6=168
	# samples	19	7
	** MAII score	log2(19/1512*10)=-2.99238681589013 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(7/168*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: LIMCH1 [Title/Abstract] AND UCHL1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	LIMCH1(41526495)-UCHL1(41258610), # samples:5
Anticipated loss of major functional domain due to fusion event.	LIMCH1-UCHL1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. LIMCH1-UCHL1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. LIMCH1-UCHL1 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. LIMCH1-UCHL1 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	UCHL1	GO:0016579	protein deubiquitination	9521656
Tgene	UCHL1	GO:0043407	negative regulation of MAP kinase activity	19477270

Fusion gene breakpoints across LIMCH1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across UCHL1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BLCA	TCGA-2F-A9KW-01A	LIMCH1	chr4	41362953	-	UCHL1	chr4	41265242	+
ChimerDB4	BLCA	TCGA-2F-A9KW-01A	LIMCH1	chr4	41362953	+	UCHL1	chr4	41265242	+
ChimerDB4	BLCA	TCGA-2F-A9KW-01A	LIMCH1	chr4	41362953	+	UCHL1	chr4	41266120	+
ChimerDB4	BLCA	TCGA-2F-A9KW-01A	LIMCH1	chr4	41362957	+	UCHL1	chr4	41265246	+
ChimerDB4	BRCA	TCGA-E9-A243-01A	LIMCH1	chr4	41361820	+	UCHL1	chr4	41270004	+
ChimerDB4	PRAD	TCGA-EJ-A46G-01A	LIMCH1	chr4	41526495	-	UCHL1	chr4	41258610	+
ChimerDB4	PRAD	TCGA-EJ-A46G-01A	LIMCH1	chr4	41526495	+	UCHL1	chr4	41258610	+
ChimerDB4	UCEC	TCGA-A5-A7WK-01A	LIMCH1	chr4	41526495	-	UCHL1	chr4	41258610	+
ChimerDB4	UCEC	TCGA-A5-A7WK-01A	LIMCH1	chr4	41526495	+	UCHL1	chr4	41258610	+
ChimerDB4	UCEC	TCGA-A5-A7WK	LIMCH1	chr4	41496623	+	UCHL1	chr4	41258610	+
ChimerDB4	UCEC	TCGA-A5-A7WK	LIMCH1	chr4	41526495	+	UCHL1	chr4	41258610	+

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Fusion Gene ORF analysis for LIMCH1-UCHL1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000313860	ENST00000284440	LIMCH1	chr4	41526495	+	UCHL1	chr4	41258610	+
5CDS-intron	ENST00000313860	ENST00000284440	LIMCH1	chr4	41496623	+	UCHL1	chr4	41258610	+
5CDS-intron	ENST00000313860	ENST00000503431	LIMCH1	chr4	41526495	+	UCHL1	chr4	41258610	+
5CDS-intron	ENST00000313860	ENST00000503431	LIMCH1	chr4	41496623	+	UCHL1	chr4	41258610	+
5CDS-intron	ENST00000313860	ENST00000504818	LIMCH1	chr4	41362953	+	UCHL1	chr4	41265242	+
5CDS-intron	ENST00000313860	ENST00000504818	LIMCH1	chr4	41362953	+	UCHL1	chr4	41266120	+
5CDS-intron	ENST00000313860	ENST00000504818	LIMCH1	chr4	41362957	+	UCHL1	chr4	41265246	+
5CDS-intron	ENST00000313860	ENST00000504818	LIMCH1	chr4	41526495	+	UCHL1	chr4	41258610	+
5CDS-intron	ENST00000313860	ENST00000504818	LIMCH1	chr4	41496623	+	UCHL1	chr4	41258610	+
5CDS-intron	ENST00000313860	ENST00000508768	LIMCH1	chr4	41362953	+	UCHL1	chr4	41265242	+
5CDS-intron	ENST00000313860	ENST00000508768	LIMCH1	chr4	41362953	+	UCHL1	chr4	41266120	+
5CDS-intron	ENST00000313860	ENST00000508768	LIMCH1	chr4	41362957	+	UCHL1	chr4	41265246	+
5CDS-intron	ENST00000313860	ENST00000508768	LIMCH1	chr4	41526495	+	UCHL1	chr4	41258610	+
5CDS-intron	ENST00000313860	ENST00000508768	LIMCH1	chr4	41496623	+	UCHL1	chr4	41258610	+
5CDS-intron	ENST00000313860	ENST00000512788	LIMCH1	chr4	41362953	+	UCHL1	chr4	41265242	+
5CDS-intron	ENST00000313860	ENST00000512788	LIMCH1	chr4	41362953	+	UCHL1	chr4	41266120	+
5CDS-intron	ENST00000313860	ENST00000512788	LIMCH1	chr4	41362957	+	UCHL1	chr4	41265246	+
5CDS-intron	ENST00000313860	ENST00000512788	LIMCH1	chr4	41526495	+	UCHL1	chr4	41258610	+
5CDS-intron	ENST00000313860	ENST00000512788	LIMCH1	chr4	41496623	+	UCHL1	chr4	41258610	+
5CDS-intron	ENST00000508501	ENST00000284440	LIMCH1	chr4	41526495	+	UCHL1	chr4	41258610	+
5CDS-intron	ENST00000508501	ENST00000284440	LIMCH1	chr4	41496623	+	UCHL1	chr4	41258610	+
5CDS-intron	ENST00000508501	ENST00000503431	LIMCH1	chr4	41526495	+	UCHL1	chr4	41258610	+
5CDS-intron	ENST00000508501	ENST00000503431	LIMCH1	chr4	41496623	+	UCHL1	chr4	41258610	+
5CDS-intron	ENST00000508501	ENST00000504818	LIMCH1	chr4	41362953	+	UCHL1	chr4	41265242	+
5CDS-intron	ENST00000508501	ENST00000504818	LIMCH1	chr4	41362953	+	UCHL1	chr4	41266120	+
5CDS-intron	ENST00000508501	ENST00000504818	LIMCH1	chr4	41362957	+	UCHL1	chr4	41265246	+
5CDS-intron	ENST00000508501	ENST00000504818	LIMCH1	chr4	41526495	+	UCHL1	chr4	41258610	+
5CDS-intron	ENST00000508501	ENST00000504818	LIMCH1	chr4	41496623	+	UCHL1	chr4	41258610	+
5CDS-intron	ENST00000508501	ENST00000508768	LIMCH1	chr4	41362953	+	UCHL1	chr4	41265242	+
5CDS-intron	ENST00000508501	ENST00000508768	LIMCH1	chr4	41362953	+	UCHL1	chr4	41266120	+
5CDS-intron	ENST00000508501	ENST00000508768	LIMCH1	chr4	41362957	+	UCHL1	chr4	41265246	+
5CDS-intron	ENST00000508501	ENST00000508768	LIMCH1	chr4	41526495	+	UCHL1	chr4	41258610	+
5CDS-intron	ENST00000508501	ENST00000508768	LIMCH1	chr4	41496623	+	UCHL1	chr4	41258610	+
5CDS-intron	ENST00000508501	ENST00000512788	LIMCH1	chr4	41362953	+	UCHL1	chr4	41265242	+
5CDS-intron	ENST00000508501	ENST00000512788	LIMCH1	chr4	41362953	+	UCHL1	chr4	41266120	+
5CDS-intron	ENST00000508501	ENST00000512788	LIMCH1	chr4	41362957	+	UCHL1	chr4	41265246	+
5CDS-intron	ENST00000508501	ENST00000512788	LIMCH1	chr4	41526495	+	UCHL1	chr4	41258610	+
5CDS-intron	ENST00000508501	ENST00000512788	LIMCH1	chr4	41496623	+	UCHL1	chr4	41258610	+
5CDS-intron	ENST00000512632	ENST00000284440	LIMCH1	chr4	41526495	+	UCHL1	chr4	41258610	+
5CDS-intron	ENST00000512632	ENST00000284440	LIMCH1	chr4	41496623	+	UCHL1	chr4	41258610	+
5CDS-intron	ENST00000512632	ENST00000503431	LIMCH1	chr4	41526495	+	UCHL1	chr4	41258610	+
5CDS-intron	ENST00000512632	ENST00000503431	LIMCH1	chr4	41496623	+	UCHL1	chr4	41258610	+
5CDS-intron	ENST00000512632	ENST00000504818	LIMCH1	chr4	41362953	+	UCHL1	chr4	41265242	+
5CDS-intron	ENST00000512632	ENST00000504818	LIMCH1	chr4	41362953	+	UCHL1	chr4	41266120	+
5CDS-intron	ENST00000512632	ENST00000504818	LIMCH1	chr4	41362957	+	UCHL1	chr4	41265246	+
5CDS-intron	ENST00000512632	ENST00000504818	LIMCH1	chr4	41526495	+	UCHL1	chr4	41258610	+
5CDS-intron	ENST00000512632	ENST00000504818	LIMCH1	chr4	41496623	+	UCHL1	chr4	41258610	+
5CDS-intron	ENST00000512632	ENST00000508768	LIMCH1	chr4	41362953	+	UCHL1	chr4	41265242	+
5CDS-intron	ENST00000512632	ENST00000508768	LIMCH1	chr4	41362953	+	UCHL1	chr4	41266120	+
5CDS-intron	ENST00000512632	ENST00000508768	LIMCH1	chr4	41362957	+	UCHL1	chr4	41265246	+
5CDS-intron	ENST00000512632	ENST00000508768	LIMCH1	chr4	41526495	+	UCHL1	chr4	41258610	+
5CDS-intron	ENST00000512632	ENST00000508768	LIMCH1	chr4	41496623	+	UCHL1	chr4	41258610	+
5CDS-intron	ENST00000512632	ENST00000512788	LIMCH1	chr4	41362953	+	UCHL1	chr4	41265242	+
5CDS-intron	ENST00000512632	ENST00000512788	LIMCH1	chr4	41362953	+	UCHL1	chr4	41266120	+
5CDS-intron	ENST00000512632	ENST00000512788	LIMCH1	chr4	41362957	+	UCHL1	chr4	41265246	+
5CDS-intron	ENST00000512632	ENST00000512788	LIMCH1	chr4	41526495	+	UCHL1	chr4	41258610	+
5CDS-intron	ENST00000512632	ENST00000512788	LIMCH1	chr4	41496623	+	UCHL1	chr4	41258610	+
5CDS-intron	ENST00000512820	ENST00000284440	LIMCH1	chr4	41526495	+	UCHL1	chr4	41258610	+
5CDS-intron	ENST00000512820	ENST00000284440	LIMCH1	chr4	41496623	+	UCHL1	chr4	41258610	+
5CDS-intron	ENST00000512820	ENST00000503431	LIMCH1	chr4	41526495	+	UCHL1	chr4	41258610	+
5CDS-intron	ENST00000512820	ENST00000503431	LIMCH1	chr4	41496623	+	UCHL1	chr4	41258610	+
5CDS-intron	ENST00000512820	ENST00000504818	LIMCH1	chr4	41362953	+	UCHL1	chr4	41265242	+
5CDS-intron	ENST00000512820	ENST00000504818	LIMCH1	chr4	41362953	+	UCHL1	chr4	41266120	+
5CDS-intron	ENST00000512820	ENST00000504818	LIMCH1	chr4	41362957	+	UCHL1	chr4	41265246	+
5CDS-intron	ENST00000512820	ENST00000504818	LIMCH1	chr4	41526495	+	UCHL1	chr4	41258610	+
5CDS-intron	ENST00000512820	ENST00000504818	LIMCH1	chr4	41496623	+	UCHL1	chr4	41258610	+
5CDS-intron	ENST00000512820	ENST00000508768	LIMCH1	chr4	41362953	+	UCHL1	chr4	41265242	+
5CDS-intron	ENST00000512820	ENST00000508768	LIMCH1	chr4	41362953	+	UCHL1	chr4	41266120	+
5CDS-intron	ENST00000512820	ENST00000508768	LIMCH1	chr4	41362957	+	UCHL1	chr4	41265246	+
5CDS-intron	ENST00000512820	ENST00000508768	LIMCH1	chr4	41526495	+	UCHL1	chr4	41258610	+
5CDS-intron	ENST00000512820	ENST00000508768	LIMCH1	chr4	41496623	+	UCHL1	chr4	41258610	+
5CDS-intron	ENST00000512820	ENST00000512788	LIMCH1	chr4	41362953	+	UCHL1	chr4	41265242	+
5CDS-intron	ENST00000512820	ENST00000512788	LIMCH1	chr4	41362953	+	UCHL1	chr4	41266120	+
5CDS-intron	ENST00000512820	ENST00000512788	LIMCH1	chr4	41362957	+	UCHL1	chr4	41265246	+
5CDS-intron	ENST00000512820	ENST00000512788	LIMCH1	chr4	41526495	+	UCHL1	chr4	41258610	+
5CDS-intron	ENST00000512820	ENST00000512788	LIMCH1	chr4	41496623	+	UCHL1	chr4	41258610	+
5CDS-intron	ENST00000512946	ENST00000284440	LIMCH1	chr4	41526495	+	UCHL1	chr4	41258610	+
5CDS-intron	ENST00000512946	ENST00000284440	LIMCH1	chr4	41496623	+	UCHL1	chr4	41258610	+
5CDS-intron	ENST00000512946	ENST00000503431	LIMCH1	chr4	41526495	+	UCHL1	chr4	41258610	+
5CDS-intron	ENST00000512946	ENST00000503431	LIMCH1	chr4	41496623	+	UCHL1	chr4	41258610	+
5CDS-intron	ENST00000512946	ENST00000504818	LIMCH1	chr4	41362953	+	UCHL1	chr4	41265242	+
5CDS-intron	ENST00000512946	ENST00000504818	LIMCH1	chr4	41362953	+	UCHL1	chr4	41266120	+
5CDS-intron	ENST00000512946	ENST00000504818	LIMCH1	chr4	41362957	+	UCHL1	chr4	41265246	+
5CDS-intron	ENST00000512946	ENST00000504818	LIMCH1	chr4	41526495	+	UCHL1	chr4	41258610	+
5CDS-intron	ENST00000512946	ENST00000504818	LIMCH1	chr4	41496623	+	UCHL1	chr4	41258610	+
5CDS-intron	ENST00000512946	ENST00000508768	LIMCH1	chr4	41362953	+	UCHL1	chr4	41265242	+
5CDS-intron	ENST00000512946	ENST00000508768	LIMCH1	chr4	41362953	+	UCHL1	chr4	41266120	+
5CDS-intron	ENST00000512946	ENST00000508768	LIMCH1	chr4	41362957	+	UCHL1	chr4	41265246	+
5CDS-intron	ENST00000512946	ENST00000508768	LIMCH1	chr4	41526495	+	UCHL1	chr4	41258610	+
5CDS-intron	ENST00000512946	ENST00000508768	LIMCH1	chr4	41496623	+	UCHL1	chr4	41258610	+
5CDS-intron	ENST00000512946	ENST00000512788	LIMCH1	chr4	41362953	+	UCHL1	chr4	41265242	+
5CDS-intron	ENST00000512946	ENST00000512788	LIMCH1	chr4	41362953	+	UCHL1	chr4	41266120	+
5CDS-intron	ENST00000512946	ENST00000512788	LIMCH1	chr4	41362957	+	UCHL1	chr4	41265246	+
5CDS-intron	ENST00000512946	ENST00000512788	LIMCH1	chr4	41526495	+	UCHL1	chr4	41258610	+
5CDS-intron	ENST00000512946	ENST00000512788	LIMCH1	chr4	41496623	+	UCHL1	chr4	41258610	+
5UTR-3CDS	ENST00000509638	ENST00000284440	LIMCH1	chr4	41362953	+	UCHL1	chr4	41265242	+
5UTR-3CDS	ENST00000509638	ENST00000284440	LIMCH1	chr4	41362953	+	UCHL1	chr4	41266120	+
5UTR-3CDS	ENST00000509638	ENST00000284440	LIMCH1	chr4	41362957	+	UCHL1	chr4	41265246	+
5UTR-3CDS	ENST00000509638	ENST00000503431	LIMCH1	chr4	41362953	+	UCHL1	chr4	41265242	+
5UTR-3CDS	ENST00000509638	ENST00000503431	LIMCH1	chr4	41362953	+	UCHL1	chr4	41266120	+
5UTR-3CDS	ENST00000509638	ENST00000503431	LIMCH1	chr4	41362957	+	UCHL1	chr4	41265246	+
5UTR-3CDS	ENST00000513024	ENST00000284440	LIMCH1	chr4	41361820	+	UCHL1	chr4	41270004	+
5UTR-3CDS	ENST00000513024	ENST00000503431	LIMCH1	chr4	41361820	+	UCHL1	chr4	41270004	+
5UTR-intron	ENST00000509638	ENST00000284440	LIMCH1	chr4	41526495	+	UCHL1	chr4	41258610	+
5UTR-intron	ENST00000509638	ENST00000503431	LIMCH1	chr4	41526495	+	UCHL1	chr4	41258610	+
5UTR-intron	ENST00000509638	ENST00000504818	LIMCH1	chr4	41362953	+	UCHL1	chr4	41265242	+
5UTR-intron	ENST00000509638	ENST00000504818	LIMCH1	chr4	41362953	+	UCHL1	chr4	41266120	+
5UTR-intron	ENST00000509638	ENST00000504818	LIMCH1	chr4	41362957	+	UCHL1	chr4	41265246	+
5UTR-intron	ENST00000509638	ENST00000504818	LIMCH1	chr4	41526495	+	UCHL1	chr4	41258610	+
5UTR-intron	ENST00000509638	ENST00000508768	LIMCH1	chr4	41362953	+	UCHL1	chr4	41265242	+
5UTR-intron	ENST00000509638	ENST00000508768	LIMCH1	chr4	41362953	+	UCHL1	chr4	41266120	+
5UTR-intron	ENST00000509638	ENST00000508768	LIMCH1	chr4	41362957	+	UCHL1	chr4	41265246	+
5UTR-intron	ENST00000509638	ENST00000508768	LIMCH1	chr4	41526495	+	UCHL1	chr4	41258610	+
5UTR-intron	ENST00000509638	ENST00000512788	LIMCH1	chr4	41362953	+	UCHL1	chr4	41265242	+
5UTR-intron	ENST00000509638	ENST00000512788	LIMCH1	chr4	41362953	+	UCHL1	chr4	41266120	+
5UTR-intron	ENST00000509638	ENST00000512788	LIMCH1	chr4	41362957	+	UCHL1	chr4	41265246	+
5UTR-intron	ENST00000509638	ENST00000512788	LIMCH1	chr4	41526495	+	UCHL1	chr4	41258610	+
5UTR-intron	ENST00000513024	ENST00000284440	LIMCH1	chr4	41526495	+	UCHL1	chr4	41258610	+
5UTR-intron	ENST00000513024	ENST00000284440	LIMCH1	chr4	41496623	+	UCHL1	chr4	41258610	+
5UTR-intron	ENST00000513024	ENST00000503431	LIMCH1	chr4	41526495	+	UCHL1	chr4	41258610	+
5UTR-intron	ENST00000513024	ENST00000503431	LIMCH1	chr4	41496623	+	UCHL1	chr4	41258610	+
5UTR-intron	ENST00000513024	ENST00000504818	LIMCH1	chr4	41361820	+	UCHL1	chr4	41270004	+
5UTR-intron	ENST00000513024	ENST00000504818	LIMCH1	chr4	41526495	+	UCHL1	chr4	41258610	+
5UTR-intron	ENST00000513024	ENST00000504818	LIMCH1	chr4	41496623	+	UCHL1	chr4	41258610	+
5UTR-intron	ENST00000513024	ENST00000508768	LIMCH1	chr4	41361820	+	UCHL1	chr4	41270004	+
5UTR-intron	ENST00000513024	ENST00000508768	LIMCH1	chr4	41526495	+	UCHL1	chr4	41258610	+
5UTR-intron	ENST00000513024	ENST00000508768	LIMCH1	chr4	41496623	+	UCHL1	chr4	41258610	+
5UTR-intron	ENST00000513024	ENST00000512788	LIMCH1	chr4	41361820	+	UCHL1	chr4	41270004	+
5UTR-intron	ENST00000513024	ENST00000512788	LIMCH1	chr4	41526495	+	UCHL1	chr4	41258610	+
5UTR-intron	ENST00000513024	ENST00000512788	LIMCH1	chr4	41496623	+	UCHL1	chr4	41258610	+
Frame-shift	ENST00000313860	ENST00000284440	LIMCH1	chr4	41362953	+	UCHL1	chr4	41266120	+
Frame-shift	ENST00000313860	ENST00000503431	LIMCH1	chr4	41362953	+	UCHL1	chr4	41266120	+
Frame-shift	ENST00000508501	ENST00000284440	LIMCH1	chr4	41362953	+	UCHL1	chr4	41266120	+
Frame-shift	ENST00000508501	ENST00000503431	LIMCH1	chr4	41362953	+	UCHL1	chr4	41266120	+
Frame-shift	ENST00000512632	ENST00000284440	LIMCH1	chr4	41362953	+	UCHL1	chr4	41266120	+
Frame-shift	ENST00000512632	ENST00000503431	LIMCH1	chr4	41362953	+	UCHL1	chr4	41266120	+
Frame-shift	ENST00000512820	ENST00000284440	LIMCH1	chr4	41362953	+	UCHL1	chr4	41266120	+
Frame-shift	ENST00000512820	ENST00000503431	LIMCH1	chr4	41362953	+	UCHL1	chr4	41266120	+
Frame-shift	ENST00000512946	ENST00000284440	LIMCH1	chr4	41362953	+	UCHL1	chr4	41266120	+
Frame-shift	ENST00000512946	ENST00000503431	LIMCH1	chr4	41362953	+	UCHL1	chr4	41266120	+
In-frame	ENST00000313860	ENST00000284440	LIMCH1	chr4	41362953	+	UCHL1	chr4	41265242	+
In-frame	ENST00000313860	ENST00000284440	LIMCH1	chr4	41362957	+	UCHL1	chr4	41265246	+
In-frame	ENST00000313860	ENST00000503431	LIMCH1	chr4	41362953	+	UCHL1	chr4	41265242	+
In-frame	ENST00000313860	ENST00000503431	LIMCH1	chr4	41362957	+	UCHL1	chr4	41265246	+
In-frame	ENST00000508501	ENST00000284440	LIMCH1	chr4	41362953	+	UCHL1	chr4	41265242	+
In-frame	ENST00000508501	ENST00000284440	LIMCH1	chr4	41362957	+	UCHL1	chr4	41265246	+
In-frame	ENST00000508501	ENST00000503431	LIMCH1	chr4	41362953	+	UCHL1	chr4	41265242	+
In-frame	ENST00000508501	ENST00000503431	LIMCH1	chr4	41362957	+	UCHL1	chr4	41265246	+
In-frame	ENST00000512632	ENST00000284440	LIMCH1	chr4	41362953	+	UCHL1	chr4	41265242	+
In-frame	ENST00000512632	ENST00000284440	LIMCH1	chr4	41362957	+	UCHL1	chr4	41265246	+
In-frame	ENST00000512632	ENST00000503431	LIMCH1	chr4	41362953	+	UCHL1	chr4	41265242	+
In-frame	ENST00000512632	ENST00000503431	LIMCH1	chr4	41362957	+	UCHL1	chr4	41265246	+
In-frame	ENST00000512820	ENST00000284440	LIMCH1	chr4	41362953	+	UCHL1	chr4	41265242	+
In-frame	ENST00000512820	ENST00000284440	LIMCH1	chr4	41362957	+	UCHL1	chr4	41265246	+
In-frame	ENST00000512820	ENST00000503431	LIMCH1	chr4	41362953	+	UCHL1	chr4	41265242	+
In-frame	ENST00000512820	ENST00000503431	LIMCH1	chr4	41362957	+	UCHL1	chr4	41265246	+
In-frame	ENST00000512946	ENST00000284440	LIMCH1	chr4	41362953	+	UCHL1	chr4	41265242	+
In-frame	ENST00000512946	ENST00000284440	LIMCH1	chr4	41362957	+	UCHL1	chr4	41265246	+
In-frame	ENST00000512946	ENST00000503431	LIMCH1	chr4	41362953	+	UCHL1	chr4	41265242	+
In-frame	ENST00000512946	ENST00000503431	LIMCH1	chr4	41362957	+	UCHL1	chr4	41265246	+
intron-3CDS	ENST00000313860	ENST00000284440	LIMCH1	chr4	41361820	+	UCHL1	chr4	41270004	+
intron-3CDS	ENST00000313860	ENST00000503431	LIMCH1	chr4	41361820	+	UCHL1	chr4	41270004	+
intron-3CDS	ENST00000381753	ENST00000284440	LIMCH1	chr4	41362953	+	UCHL1	chr4	41265242	+
intron-3CDS	ENST00000381753	ENST00000284440	LIMCH1	chr4	41362953	+	UCHL1	chr4	41266120	+
intron-3CDS	ENST00000381753	ENST00000284440	LIMCH1	chr4	41362957	+	UCHL1	chr4	41265246	+
intron-3CDS	ENST00000381753	ENST00000284440	LIMCH1	chr4	41361820	+	UCHL1	chr4	41270004	+
intron-3CDS	ENST00000381753	ENST00000503431	LIMCH1	chr4	41362953	+	UCHL1	chr4	41265242	+
intron-3CDS	ENST00000381753	ENST00000503431	LIMCH1	chr4	41362953	+	UCHL1	chr4	41266120	+
intron-3CDS	ENST00000381753	ENST00000503431	LIMCH1	chr4	41362957	+	UCHL1	chr4	41265246	+
intron-3CDS	ENST00000381753	ENST00000503431	LIMCH1	chr4	41361820	+	UCHL1	chr4	41270004	+
intron-3CDS	ENST00000396595	ENST00000284440	LIMCH1	chr4	41362953	+	UCHL1	chr4	41265242	+
intron-3CDS	ENST00000396595	ENST00000284440	LIMCH1	chr4	41362953	+	UCHL1	chr4	41266120	+
intron-3CDS	ENST00000396595	ENST00000284440	LIMCH1	chr4	41362957	+	UCHL1	chr4	41265246	+
intron-3CDS	ENST00000396595	ENST00000284440	LIMCH1	chr4	41361820	+	UCHL1	chr4	41270004	+
intron-3CDS	ENST00000396595	ENST00000503431	LIMCH1	chr4	41362953	+	UCHL1	chr4	41265242	+
intron-3CDS	ENST00000396595	ENST00000503431	LIMCH1	chr4	41362953	+	UCHL1	chr4	41266120	+
intron-3CDS	ENST00000396595	ENST00000503431	LIMCH1	chr4	41362957	+	UCHL1	chr4	41265246	+
intron-3CDS	ENST00000396595	ENST00000503431	LIMCH1	chr4	41361820	+	UCHL1	chr4	41270004	+
intron-3CDS	ENST00000503057	ENST00000284440	LIMCH1	chr4	41362953	+	UCHL1	chr4	41265242	+
intron-3CDS	ENST00000503057	ENST00000284440	LIMCH1	chr4	41362953	+	UCHL1	chr4	41266120	+
intron-3CDS	ENST00000503057	ENST00000284440	LIMCH1	chr4	41362957	+	UCHL1	chr4	41265246	+
intron-3CDS	ENST00000503057	ENST00000284440	LIMCH1	chr4	41361820	+	UCHL1	chr4	41270004	+
intron-3CDS	ENST00000503057	ENST00000503431	LIMCH1	chr4	41362953	+	UCHL1	chr4	41265242	+
intron-3CDS	ENST00000503057	ENST00000503431	LIMCH1	chr4	41362953	+	UCHL1	chr4	41266120	+
intron-3CDS	ENST00000503057	ENST00000503431	LIMCH1	chr4	41362957	+	UCHL1	chr4	41265246	+
intron-3CDS	ENST00000503057	ENST00000503431	LIMCH1	chr4	41361820	+	UCHL1	chr4	41270004	+
intron-3CDS	ENST00000508501	ENST00000284440	LIMCH1	chr4	41361820	+	UCHL1	chr4	41270004	+
intron-3CDS	ENST00000508501	ENST00000503431	LIMCH1	chr4	41361820	+	UCHL1	chr4	41270004	+
intron-3CDS	ENST00000509277	ENST00000284440	LIMCH1	chr4	41362953	+	UCHL1	chr4	41265242	+
intron-3CDS	ENST00000509277	ENST00000284440	LIMCH1	chr4	41362953	+	UCHL1	chr4	41266120	+
intron-3CDS	ENST00000509277	ENST00000284440	LIMCH1	chr4	41362957	+	UCHL1	chr4	41265246	+
intron-3CDS	ENST00000509277	ENST00000284440	LIMCH1	chr4	41361820	+	UCHL1	chr4	41270004	+
intron-3CDS	ENST00000509277	ENST00000503431	LIMCH1	chr4	41362953	+	UCHL1	chr4	41265242	+
intron-3CDS	ENST00000509277	ENST00000503431	LIMCH1	chr4	41362953	+	UCHL1	chr4	41266120	+
intron-3CDS	ENST00000509277	ENST00000503431	LIMCH1	chr4	41362957	+	UCHL1	chr4	41265246	+
intron-3CDS	ENST00000509277	ENST00000503431	LIMCH1	chr4	41361820	+	UCHL1	chr4	41270004	+
intron-3CDS	ENST00000509454	ENST00000284440	LIMCH1	chr4	41362953	+	UCHL1	chr4	41265242	+
intron-3CDS	ENST00000509454	ENST00000284440	LIMCH1	chr4	41362953	+	UCHL1	chr4	41266120	+
intron-3CDS	ENST00000509454	ENST00000284440	LIMCH1	chr4	41362957	+	UCHL1	chr4	41265246	+
intron-3CDS	ENST00000509454	ENST00000284440	LIMCH1	chr4	41361820	+	UCHL1	chr4	41270004	+
intron-3CDS	ENST00000509454	ENST00000503431	LIMCH1	chr4	41362953	+	UCHL1	chr4	41265242	+
intron-3CDS	ENST00000509454	ENST00000503431	LIMCH1	chr4	41362953	+	UCHL1	chr4	41266120	+
intron-3CDS	ENST00000509454	ENST00000503431	LIMCH1	chr4	41362957	+	UCHL1	chr4	41265246	+
intron-3CDS	ENST00000509454	ENST00000503431	LIMCH1	chr4	41361820	+	UCHL1	chr4	41270004	+
intron-3CDS	ENST00000509638	ENST00000284440	LIMCH1	chr4	41361820	+	UCHL1	chr4	41270004	+
intron-3CDS	ENST00000509638	ENST00000503431	LIMCH1	chr4	41361820	+	UCHL1	chr4	41270004	+
intron-3CDS	ENST00000511496	ENST00000284440	LIMCH1	chr4	41362953	+	UCHL1	chr4	41265242	+
intron-3CDS	ENST00000511496	ENST00000284440	LIMCH1	chr4	41362953	+	UCHL1	chr4	41266120	+
intron-3CDS	ENST00000511496	ENST00000284440	LIMCH1	chr4	41362957	+	UCHL1	chr4	41265246	+
intron-3CDS	ENST00000511496	ENST00000284440	LIMCH1	chr4	41361820	+	UCHL1	chr4	41270004	+
intron-3CDS	ENST00000511496	ENST00000503431	LIMCH1	chr4	41362953	+	UCHL1	chr4	41265242	+
intron-3CDS	ENST00000511496	ENST00000503431	LIMCH1	chr4	41362953	+	UCHL1	chr4	41266120	+
intron-3CDS	ENST00000511496	ENST00000503431	LIMCH1	chr4	41362957	+	UCHL1	chr4	41265246	+
intron-3CDS	ENST00000511496	ENST00000503431	LIMCH1	chr4	41361820	+	UCHL1	chr4	41270004	+
intron-3CDS	ENST00000512632	ENST00000284440	LIMCH1	chr4	41361820	+	UCHL1	chr4	41270004	+
intron-3CDS	ENST00000512632	ENST00000503431	LIMCH1	chr4	41361820	+	UCHL1	chr4	41270004	+
intron-3CDS	ENST00000512820	ENST00000284440	LIMCH1	chr4	41361820	+	UCHL1	chr4	41270004	+
intron-3CDS	ENST00000512820	ENST00000503431	LIMCH1	chr4	41361820	+	UCHL1	chr4	41270004	+
intron-3CDS	ENST00000512946	ENST00000284440	LIMCH1	chr4	41361820	+	UCHL1	chr4	41270004	+
intron-3CDS	ENST00000512946	ENST00000503431	LIMCH1	chr4	41361820	+	UCHL1	chr4	41270004	+
intron-3CDS	ENST00000513024	ENST00000284440	LIMCH1	chr4	41362953	+	UCHL1	chr4	41265242	+
intron-3CDS	ENST00000513024	ENST00000284440	LIMCH1	chr4	41362953	+	UCHL1	chr4	41266120	+
intron-3CDS	ENST00000513024	ENST00000284440	LIMCH1	chr4	41362957	+	UCHL1	chr4	41265246	+
intron-3CDS	ENST00000513024	ENST00000503431	LIMCH1	chr4	41362953	+	UCHL1	chr4	41265242	+
intron-3CDS	ENST00000513024	ENST00000503431	LIMCH1	chr4	41362953	+	UCHL1	chr4	41266120	+
intron-3CDS	ENST00000513024	ENST00000503431	LIMCH1	chr4	41362957	+	UCHL1	chr4	41265246	+
intron-3CDS	ENST00000514096	ENST00000284440	LIMCH1	chr4	41362953	+	UCHL1	chr4	41265242	+
intron-3CDS	ENST00000514096	ENST00000284440	LIMCH1	chr4	41362953	+	UCHL1	chr4	41266120	+
intron-3CDS	ENST00000514096	ENST00000284440	LIMCH1	chr4	41362957	+	UCHL1	chr4	41265246	+
intron-3CDS	ENST00000514096	ENST00000284440	LIMCH1	chr4	41361820	+	UCHL1	chr4	41270004	+
intron-3CDS	ENST00000514096	ENST00000503431	LIMCH1	chr4	41362953	+	UCHL1	chr4	41265242	+
intron-3CDS	ENST00000514096	ENST00000503431	LIMCH1	chr4	41362953	+	UCHL1	chr4	41266120	+
intron-3CDS	ENST00000514096	ENST00000503431	LIMCH1	chr4	41362957	+	UCHL1	chr4	41265246	+
intron-3CDS	ENST00000514096	ENST00000503431	LIMCH1	chr4	41361820	+	UCHL1	chr4	41270004	+
intron-3CDS	ENST00000515785	ENST00000284440	LIMCH1	chr4	41362953	+	UCHL1	chr4	41265242	+
intron-3CDS	ENST00000515785	ENST00000284440	LIMCH1	chr4	41362953	+	UCHL1	chr4	41266120	+
intron-3CDS	ENST00000515785	ENST00000284440	LIMCH1	chr4	41362957	+	UCHL1	chr4	41265246	+
intron-3CDS	ENST00000515785	ENST00000284440	LIMCH1	chr4	41361820	+	UCHL1	chr4	41270004	+
intron-3CDS	ENST00000515785	ENST00000503431	LIMCH1	chr4	41362953	+	UCHL1	chr4	41265242	+
intron-3CDS	ENST00000515785	ENST00000503431	LIMCH1	chr4	41362953	+	UCHL1	chr4	41266120	+
intron-3CDS	ENST00000515785	ENST00000503431	LIMCH1	chr4	41362957	+	UCHL1	chr4	41265246	+
intron-3CDS	ENST00000515785	ENST00000503431	LIMCH1	chr4	41361820	+	UCHL1	chr4	41270004	+
intron-intron	ENST00000313860	ENST00000504818	LIMCH1	chr4	41361820	+	UCHL1	chr4	41270004	+
intron-intron	ENST00000313860	ENST00000508768	LIMCH1	chr4	41361820	+	UCHL1	chr4	41270004	+
intron-intron	ENST00000313860	ENST00000512788	LIMCH1	chr4	41361820	+	UCHL1	chr4	41270004	+
intron-intron	ENST00000381753	ENST00000284440	LIMCH1	chr4	41526495	+	UCHL1	chr4	41258610	+
intron-intron	ENST00000381753	ENST00000284440	LIMCH1	chr4	41496623	+	UCHL1	chr4	41258610	+
intron-intron	ENST00000381753	ENST00000503431	LIMCH1	chr4	41526495	+	UCHL1	chr4	41258610	+
intron-intron	ENST00000381753	ENST00000503431	LIMCH1	chr4	41496623	+	UCHL1	chr4	41258610	+
intron-intron	ENST00000381753	ENST00000504818	LIMCH1	chr4	41362953	+	UCHL1	chr4	41265242	+
intron-intron	ENST00000381753	ENST00000504818	LIMCH1	chr4	41362953	+	UCHL1	chr4	41266120	+
intron-intron	ENST00000381753	ENST00000504818	LIMCH1	chr4	41362957	+	UCHL1	chr4	41265246	+
intron-intron	ENST00000381753	ENST00000504818	LIMCH1	chr4	41361820	+	UCHL1	chr4	41270004	+
intron-intron	ENST00000381753	ENST00000504818	LIMCH1	chr4	41526495	+	UCHL1	chr4	41258610	+
intron-intron	ENST00000381753	ENST00000504818	LIMCH1	chr4	41496623	+	UCHL1	chr4	41258610	+
intron-intron	ENST00000381753	ENST00000508768	LIMCH1	chr4	41362953	+	UCHL1	chr4	41265242	+
intron-intron	ENST00000381753	ENST00000508768	LIMCH1	chr4	41362953	+	UCHL1	chr4	41266120	+
intron-intron	ENST00000381753	ENST00000508768	LIMCH1	chr4	41362957	+	UCHL1	chr4	41265246	+
intron-intron	ENST00000381753	ENST00000508768	LIMCH1	chr4	41361820	+	UCHL1	chr4	41270004	+
intron-intron	ENST00000381753	ENST00000508768	LIMCH1	chr4	41526495	+	UCHL1	chr4	41258610	+
intron-intron	ENST00000381753	ENST00000508768	LIMCH1	chr4	41496623	+	UCHL1	chr4	41258610	+
intron-intron	ENST00000381753	ENST00000512788	LIMCH1	chr4	41362953	+	UCHL1	chr4	41265242	+
intron-intron	ENST00000381753	ENST00000512788	LIMCH1	chr4	41362953	+	UCHL1	chr4	41266120	+
intron-intron	ENST00000381753	ENST00000512788	LIMCH1	chr4	41362957	+	UCHL1	chr4	41265246	+
intron-intron	ENST00000381753	ENST00000512788	LIMCH1	chr4	41361820	+	UCHL1	chr4	41270004	+
intron-intron	ENST00000381753	ENST00000512788	LIMCH1	chr4	41526495	+	UCHL1	chr4	41258610	+
intron-intron	ENST00000381753	ENST00000512788	LIMCH1	chr4	41496623	+	UCHL1	chr4	41258610	+
intron-intron	ENST00000396595	ENST00000284440	LIMCH1	chr4	41526495	+	UCHL1	chr4	41258610	+
intron-intron	ENST00000396595	ENST00000284440	LIMCH1	chr4	41496623	+	UCHL1	chr4	41258610	+
intron-intron	ENST00000396595	ENST00000503431	LIMCH1	chr4	41526495	+	UCHL1	chr4	41258610	+
intron-intron	ENST00000396595	ENST00000503431	LIMCH1	chr4	41496623	+	UCHL1	chr4	41258610	+
intron-intron	ENST00000396595	ENST00000504818	LIMCH1	chr4	41362953	+	UCHL1	chr4	41265242	+
intron-intron	ENST00000396595	ENST00000504818	LIMCH1	chr4	41362953	+	UCHL1	chr4	41266120	+
intron-intron	ENST00000396595	ENST00000504818	LIMCH1	chr4	41362957	+	UCHL1	chr4	41265246	+
intron-intron	ENST00000396595	ENST00000504818	LIMCH1	chr4	41361820	+	UCHL1	chr4	41270004	+
intron-intron	ENST00000396595	ENST00000504818	LIMCH1	chr4	41526495	+	UCHL1	chr4	41258610	+
intron-intron	ENST00000396595	ENST00000504818	LIMCH1	chr4	41496623	+	UCHL1	chr4	41258610	+
intron-intron	ENST00000396595	ENST00000508768	LIMCH1	chr4	41362953	+	UCHL1	chr4	41265242	+
intron-intron	ENST00000396595	ENST00000508768	LIMCH1	chr4	41362953	+	UCHL1	chr4	41266120	+
intron-intron	ENST00000396595	ENST00000508768	LIMCH1	chr4	41362957	+	UCHL1	chr4	41265246	+
intron-intron	ENST00000396595	ENST00000508768	LIMCH1	chr4	41361820	+	UCHL1	chr4	41270004	+
intron-intron	ENST00000396595	ENST00000508768	LIMCH1	chr4	41526495	+	UCHL1	chr4	41258610	+
intron-intron	ENST00000396595	ENST00000508768	LIMCH1	chr4	41496623	+	UCHL1	chr4	41258610	+
intron-intron	ENST00000396595	ENST00000512788	LIMCH1	chr4	41362953	+	UCHL1	chr4	41265242	+
intron-intron	ENST00000396595	ENST00000512788	LIMCH1	chr4	41362953	+	UCHL1	chr4	41266120	+
intron-intron	ENST00000396595	ENST00000512788	LIMCH1	chr4	41362957	+	UCHL1	chr4	41265246	+
intron-intron	ENST00000396595	ENST00000512788	LIMCH1	chr4	41361820	+	UCHL1	chr4	41270004	+
intron-intron	ENST00000396595	ENST00000512788	LIMCH1	chr4	41526495	+	UCHL1	chr4	41258610	+
intron-intron	ENST00000396595	ENST00000512788	LIMCH1	chr4	41496623	+	UCHL1	chr4	41258610	+
intron-intron	ENST00000503057	ENST00000284440	LIMCH1	chr4	41526495	+	UCHL1	chr4	41258610	+
intron-intron	ENST00000503057	ENST00000284440	LIMCH1	chr4	41496623	+	UCHL1	chr4	41258610	+
intron-intron	ENST00000503057	ENST00000503431	LIMCH1	chr4	41526495	+	UCHL1	chr4	41258610	+
intron-intron	ENST00000503057	ENST00000503431	LIMCH1	chr4	41496623	+	UCHL1	chr4	41258610	+
intron-intron	ENST00000503057	ENST00000504818	LIMCH1	chr4	41362953	+	UCHL1	chr4	41265242	+
intron-intron	ENST00000503057	ENST00000504818	LIMCH1	chr4	41362953	+	UCHL1	chr4	41266120	+
intron-intron	ENST00000503057	ENST00000504818	LIMCH1	chr4	41362957	+	UCHL1	chr4	41265246	+
intron-intron	ENST00000503057	ENST00000504818	LIMCH1	chr4	41361820	+	UCHL1	chr4	41270004	+
intron-intron	ENST00000503057	ENST00000504818	LIMCH1	chr4	41526495	+	UCHL1	chr4	41258610	+
intron-intron	ENST00000503057	ENST00000504818	LIMCH1	chr4	41496623	+	UCHL1	chr4	41258610	+
intron-intron	ENST00000503057	ENST00000508768	LIMCH1	chr4	41362953	+	UCHL1	chr4	41265242	+
intron-intron	ENST00000503057	ENST00000508768	LIMCH1	chr4	41362953	+	UCHL1	chr4	41266120	+
intron-intron	ENST00000503057	ENST00000508768	LIMCH1	chr4	41362957	+	UCHL1	chr4	41265246	+
intron-intron	ENST00000503057	ENST00000508768	LIMCH1	chr4	41361820	+	UCHL1	chr4	41270004	+
intron-intron	ENST00000503057	ENST00000508768	LIMCH1	chr4	41526495	+	UCHL1	chr4	41258610	+
intron-intron	ENST00000503057	ENST00000508768	LIMCH1	chr4	41496623	+	UCHL1	chr4	41258610	+
intron-intron	ENST00000503057	ENST00000512788	LIMCH1	chr4	41362953	+	UCHL1	chr4	41265242	+
intron-intron	ENST00000503057	ENST00000512788	LIMCH1	chr4	41362953	+	UCHL1	chr4	41266120	+
intron-intron	ENST00000503057	ENST00000512788	LIMCH1	chr4	41362957	+	UCHL1	chr4	41265246	+
intron-intron	ENST00000503057	ENST00000512788	LIMCH1	chr4	41361820	+	UCHL1	chr4	41270004	+
intron-intron	ENST00000503057	ENST00000512788	LIMCH1	chr4	41526495	+	UCHL1	chr4	41258610	+
intron-intron	ENST00000503057	ENST00000512788	LIMCH1	chr4	41496623	+	UCHL1	chr4	41258610	+
intron-intron	ENST00000508501	ENST00000504818	LIMCH1	chr4	41361820	+	UCHL1	chr4	41270004	+
intron-intron	ENST00000508501	ENST00000508768	LIMCH1	chr4	41361820	+	UCHL1	chr4	41270004	+
intron-intron	ENST00000508501	ENST00000512788	LIMCH1	chr4	41361820	+	UCHL1	chr4	41270004	+
intron-intron	ENST00000509277	ENST00000284440	LIMCH1	chr4	41526495	+	UCHL1	chr4	41258610	+
intron-intron	ENST00000509277	ENST00000284440	LIMCH1	chr4	41496623	+	UCHL1	chr4	41258610	+
intron-intron	ENST00000509277	ENST00000503431	LIMCH1	chr4	41526495	+	UCHL1	chr4	41258610	+
intron-intron	ENST00000509277	ENST00000503431	LIMCH1	chr4	41496623	+	UCHL1	chr4	41258610	+
intron-intron	ENST00000509277	ENST00000504818	LIMCH1	chr4	41362953	+	UCHL1	chr4	41265242	+
intron-intron	ENST00000509277	ENST00000504818	LIMCH1	chr4	41362953	+	UCHL1	chr4	41266120	+
intron-intron	ENST00000509277	ENST00000504818	LIMCH1	chr4	41362957	+	UCHL1	chr4	41265246	+
intron-intron	ENST00000509277	ENST00000504818	LIMCH1	chr4	41361820	+	UCHL1	chr4	41270004	+
intron-intron	ENST00000509277	ENST00000504818	LIMCH1	chr4	41526495	+	UCHL1	chr4	41258610	+
intron-intron	ENST00000509277	ENST00000504818	LIMCH1	chr4	41496623	+	UCHL1	chr4	41258610	+
intron-intron	ENST00000509277	ENST00000508768	LIMCH1	chr4	41362953	+	UCHL1	chr4	41265242	+
intron-intron	ENST00000509277	ENST00000508768	LIMCH1	chr4	41362953	+	UCHL1	chr4	41266120	+
intron-intron	ENST00000509277	ENST00000508768	LIMCH1	chr4	41362957	+	UCHL1	chr4	41265246	+
intron-intron	ENST00000509277	ENST00000508768	LIMCH1	chr4	41361820	+	UCHL1	chr4	41270004	+
intron-intron	ENST00000509277	ENST00000508768	LIMCH1	chr4	41526495	+	UCHL1	chr4	41258610	+
intron-intron	ENST00000509277	ENST00000508768	LIMCH1	chr4	41496623	+	UCHL1	chr4	41258610	+
intron-intron	ENST00000509277	ENST00000512788	LIMCH1	chr4	41362953	+	UCHL1	chr4	41265242	+
intron-intron	ENST00000509277	ENST00000512788	LIMCH1	chr4	41362953	+	UCHL1	chr4	41266120	+
intron-intron	ENST00000509277	ENST00000512788	LIMCH1	chr4	41362957	+	UCHL1	chr4	41265246	+
intron-intron	ENST00000509277	ENST00000512788	LIMCH1	chr4	41361820	+	UCHL1	chr4	41270004	+
intron-intron	ENST00000509277	ENST00000512788	LIMCH1	chr4	41526495	+	UCHL1	chr4	41258610	+
intron-intron	ENST00000509277	ENST00000512788	LIMCH1	chr4	41496623	+	UCHL1	chr4	41258610	+
intron-intron	ENST00000509454	ENST00000284440	LIMCH1	chr4	41526495	+	UCHL1	chr4	41258610	+
intron-intron	ENST00000509454	ENST00000284440	LIMCH1	chr4	41496623	+	UCHL1	chr4	41258610	+
intron-intron	ENST00000509454	ENST00000503431	LIMCH1	chr4	41526495	+	UCHL1	chr4	41258610	+
intron-intron	ENST00000509454	ENST00000503431	LIMCH1	chr4	41496623	+	UCHL1	chr4	41258610	+
intron-intron	ENST00000509454	ENST00000504818	LIMCH1	chr4	41362953	+	UCHL1	chr4	41265242	+
intron-intron	ENST00000509454	ENST00000504818	LIMCH1	chr4	41362953	+	UCHL1	chr4	41266120	+
intron-intron	ENST00000509454	ENST00000504818	LIMCH1	chr4	41362957	+	UCHL1	chr4	41265246	+
intron-intron	ENST00000509454	ENST00000504818	LIMCH1	chr4	41361820	+	UCHL1	chr4	41270004	+
intron-intron	ENST00000509454	ENST00000504818	LIMCH1	chr4	41526495	+	UCHL1	chr4	41258610	+
intron-intron	ENST00000509454	ENST00000504818	LIMCH1	chr4	41496623	+	UCHL1	chr4	41258610	+
intron-intron	ENST00000509454	ENST00000508768	LIMCH1	chr4	41362953	+	UCHL1	chr4	41265242	+
intron-intron	ENST00000509454	ENST00000508768	LIMCH1	chr4	41362953	+	UCHL1	chr4	41266120	+
intron-intron	ENST00000509454	ENST00000508768	LIMCH1	chr4	41362957	+	UCHL1	chr4	41265246	+
intron-intron	ENST00000509454	ENST00000508768	LIMCH1	chr4	41361820	+	UCHL1	chr4	41270004	+
intron-intron	ENST00000509454	ENST00000508768	LIMCH1	chr4	41526495	+	UCHL1	chr4	41258610	+
intron-intron	ENST00000509454	ENST00000508768	LIMCH1	chr4	41496623	+	UCHL1	chr4	41258610	+
intron-intron	ENST00000509454	ENST00000512788	LIMCH1	chr4	41362953	+	UCHL1	chr4	41265242	+
intron-intron	ENST00000509454	ENST00000512788	LIMCH1	chr4	41362953	+	UCHL1	chr4	41266120	+
intron-intron	ENST00000509454	ENST00000512788	LIMCH1	chr4	41362957	+	UCHL1	chr4	41265246	+
intron-intron	ENST00000509454	ENST00000512788	LIMCH1	chr4	41361820	+	UCHL1	chr4	41270004	+
intron-intron	ENST00000509454	ENST00000512788	LIMCH1	chr4	41526495	+	UCHL1	chr4	41258610	+
intron-intron	ENST00000509454	ENST00000512788	LIMCH1	chr4	41496623	+	UCHL1	chr4	41258610	+
intron-intron	ENST00000509638	ENST00000284440	LIMCH1	chr4	41496623	+	UCHL1	chr4	41258610	+
intron-intron	ENST00000509638	ENST00000503431	LIMCH1	chr4	41496623	+	UCHL1	chr4	41258610	+
intron-intron	ENST00000509638	ENST00000504818	LIMCH1	chr4	41361820	+	UCHL1	chr4	41270004	+
intron-intron	ENST00000509638	ENST00000504818	LIMCH1	chr4	41496623	+	UCHL1	chr4	41258610	+
intron-intron	ENST00000509638	ENST00000508768	LIMCH1	chr4	41361820	+	UCHL1	chr4	41270004	+
intron-intron	ENST00000509638	ENST00000508768	LIMCH1	chr4	41496623	+	UCHL1	chr4	41258610	+
intron-intron	ENST00000509638	ENST00000512788	LIMCH1	chr4	41361820	+	UCHL1	chr4	41270004	+
intron-intron	ENST00000509638	ENST00000512788	LIMCH1	chr4	41496623	+	UCHL1	chr4	41258610	+
intron-intron	ENST00000511496	ENST00000284440	LIMCH1	chr4	41526495	+	UCHL1	chr4	41258610	+
intron-intron	ENST00000511496	ENST00000284440	LIMCH1	chr4	41496623	+	UCHL1	chr4	41258610	+
intron-intron	ENST00000511496	ENST00000503431	LIMCH1	chr4	41526495	+	UCHL1	chr4	41258610	+
intron-intron	ENST00000511496	ENST00000503431	LIMCH1	chr4	41496623	+	UCHL1	chr4	41258610	+
intron-intron	ENST00000511496	ENST00000504818	LIMCH1	chr4	41362953	+	UCHL1	chr4	41265242	+
intron-intron	ENST00000511496	ENST00000504818	LIMCH1	chr4	41362953	+	UCHL1	chr4	41266120	+
intron-intron	ENST00000511496	ENST00000504818	LIMCH1	chr4	41362957	+	UCHL1	chr4	41265246	+
intron-intron	ENST00000511496	ENST00000504818	LIMCH1	chr4	41361820	+	UCHL1	chr4	41270004	+
intron-intron	ENST00000511496	ENST00000504818	LIMCH1	chr4	41526495	+	UCHL1	chr4	41258610	+
intron-intron	ENST00000511496	ENST00000504818	LIMCH1	chr4	41496623	+	UCHL1	chr4	41258610	+
intron-intron	ENST00000511496	ENST00000508768	LIMCH1	chr4	41362953	+	UCHL1	chr4	41265242	+
intron-intron	ENST00000511496	ENST00000508768	LIMCH1	chr4	41362953	+	UCHL1	chr4	41266120	+
intron-intron	ENST00000511496	ENST00000508768	LIMCH1	chr4	41362957	+	UCHL1	chr4	41265246	+
intron-intron	ENST00000511496	ENST00000508768	LIMCH1	chr4	41361820	+	UCHL1	chr4	41270004	+
intron-intron	ENST00000511496	ENST00000508768	LIMCH1	chr4	41526495	+	UCHL1	chr4	41258610	+
intron-intron	ENST00000511496	ENST00000508768	LIMCH1	chr4	41496623	+	UCHL1	chr4	41258610	+
intron-intron	ENST00000511496	ENST00000512788	LIMCH1	chr4	41362953	+	UCHL1	chr4	41265242	+
intron-intron	ENST00000511496	ENST00000512788	LIMCH1	chr4	41362953	+	UCHL1	chr4	41266120	+
intron-intron	ENST00000511496	ENST00000512788	LIMCH1	chr4	41362957	+	UCHL1	chr4	41265246	+
intron-intron	ENST00000511496	ENST00000512788	LIMCH1	chr4	41361820	+	UCHL1	chr4	41270004	+
intron-intron	ENST00000511496	ENST00000512788	LIMCH1	chr4	41526495	+	UCHL1	chr4	41258610	+
intron-intron	ENST00000511496	ENST00000512788	LIMCH1	chr4	41496623	+	UCHL1	chr4	41258610	+
intron-intron	ENST00000512632	ENST00000504818	LIMCH1	chr4	41361820	+	UCHL1	chr4	41270004	+
intron-intron	ENST00000512632	ENST00000508768	LIMCH1	chr4	41361820	+	UCHL1	chr4	41270004	+
intron-intron	ENST00000512632	ENST00000512788	LIMCH1	chr4	41361820	+	UCHL1	chr4	41270004	+
intron-intron	ENST00000512820	ENST00000504818	LIMCH1	chr4	41361820	+	UCHL1	chr4	41270004	+
intron-intron	ENST00000512820	ENST00000508768	LIMCH1	chr4	41361820	+	UCHL1	chr4	41270004	+
intron-intron	ENST00000512820	ENST00000512788	LIMCH1	chr4	41361820	+	UCHL1	chr4	41270004	+
intron-intron	ENST00000512946	ENST00000504818	LIMCH1	chr4	41361820	+	UCHL1	chr4	41270004	+
intron-intron	ENST00000512946	ENST00000508768	LIMCH1	chr4	41361820	+	UCHL1	chr4	41270004	+
intron-intron	ENST00000512946	ENST00000512788	LIMCH1	chr4	41361820	+	UCHL1	chr4	41270004	+
intron-intron	ENST00000513024	ENST00000504818	LIMCH1	chr4	41362953	+	UCHL1	chr4	41265242	+
intron-intron	ENST00000513024	ENST00000504818	LIMCH1	chr4	41362953	+	UCHL1	chr4	41266120	+
intron-intron	ENST00000513024	ENST00000504818	LIMCH1	chr4	41362957	+	UCHL1	chr4	41265246	+
intron-intron	ENST00000513024	ENST00000508768	LIMCH1	chr4	41362953	+	UCHL1	chr4	41265242	+
intron-intron	ENST00000513024	ENST00000508768	LIMCH1	chr4	41362953	+	UCHL1	chr4	41266120	+
intron-intron	ENST00000513024	ENST00000508768	LIMCH1	chr4	41362957	+	UCHL1	chr4	41265246	+
intron-intron	ENST00000513024	ENST00000512788	LIMCH1	chr4	41362953	+	UCHL1	chr4	41265242	+
intron-intron	ENST00000513024	ENST00000512788	LIMCH1	chr4	41362953	+	UCHL1	chr4	41266120	+
intron-intron	ENST00000513024	ENST00000512788	LIMCH1	chr4	41362957	+	UCHL1	chr4	41265246	+
intron-intron	ENST00000514096	ENST00000284440	LIMCH1	chr4	41526495	+	UCHL1	chr4	41258610	+
intron-intron	ENST00000514096	ENST00000284440	LIMCH1	chr4	41496623	+	UCHL1	chr4	41258610	+
intron-intron	ENST00000514096	ENST00000503431	LIMCH1	chr4	41526495	+	UCHL1	chr4	41258610	+
intron-intron	ENST00000514096	ENST00000503431	LIMCH1	chr4	41496623	+	UCHL1	chr4	41258610	+
intron-intron	ENST00000514096	ENST00000504818	LIMCH1	chr4	41362953	+	UCHL1	chr4	41265242	+
intron-intron	ENST00000514096	ENST00000504818	LIMCH1	chr4	41362953	+	UCHL1	chr4	41266120	+
intron-intron	ENST00000514096	ENST00000504818	LIMCH1	chr4	41362957	+	UCHL1	chr4	41265246	+
intron-intron	ENST00000514096	ENST00000504818	LIMCH1	chr4	41361820	+	UCHL1	chr4	41270004	+
intron-intron	ENST00000514096	ENST00000504818	LIMCH1	chr4	41526495	+	UCHL1	chr4	41258610	+
intron-intron	ENST00000514096	ENST00000504818	LIMCH1	chr4	41496623	+	UCHL1	chr4	41258610	+
intron-intron	ENST00000514096	ENST00000508768	LIMCH1	chr4	41362953	+	UCHL1	chr4	41265242	+
intron-intron	ENST00000514096	ENST00000508768	LIMCH1	chr4	41362953	+	UCHL1	chr4	41266120	+
intron-intron	ENST00000514096	ENST00000508768	LIMCH1	chr4	41362957	+	UCHL1	chr4	41265246	+
intron-intron	ENST00000514096	ENST00000508768	LIMCH1	chr4	41361820	+	UCHL1	chr4	41270004	+
intron-intron	ENST00000514096	ENST00000508768	LIMCH1	chr4	41526495	+	UCHL1	chr4	41258610	+
intron-intron	ENST00000514096	ENST00000508768	LIMCH1	chr4	41496623	+	UCHL1	chr4	41258610	+
intron-intron	ENST00000514096	ENST00000512788	LIMCH1	chr4	41362953	+	UCHL1	chr4	41265242	+
intron-intron	ENST00000514096	ENST00000512788	LIMCH1	chr4	41362953	+	UCHL1	chr4	41266120	+
intron-intron	ENST00000514096	ENST00000512788	LIMCH1	chr4	41362957	+	UCHL1	chr4	41265246	+
intron-intron	ENST00000514096	ENST00000512788	LIMCH1	chr4	41361820	+	UCHL1	chr4	41270004	+
intron-intron	ENST00000514096	ENST00000512788	LIMCH1	chr4	41526495	+	UCHL1	chr4	41258610	+
intron-intron	ENST00000514096	ENST00000512788	LIMCH1	chr4	41496623	+	UCHL1	chr4	41258610	+
intron-intron	ENST00000515785	ENST00000284440	LIMCH1	chr4	41526495	+	UCHL1	chr4	41258610	+
intron-intron	ENST00000515785	ENST00000284440	LIMCH1	chr4	41496623	+	UCHL1	chr4	41258610	+
intron-intron	ENST00000515785	ENST00000503431	LIMCH1	chr4	41526495	+	UCHL1	chr4	41258610	+
intron-intron	ENST00000515785	ENST00000503431	LIMCH1	chr4	41496623	+	UCHL1	chr4	41258610	+
intron-intron	ENST00000515785	ENST00000504818	LIMCH1	chr4	41362953	+	UCHL1	chr4	41265242	+
intron-intron	ENST00000515785	ENST00000504818	LIMCH1	chr4	41362953	+	UCHL1	chr4	41266120	+
intron-intron	ENST00000515785	ENST00000504818	LIMCH1	chr4	41362957	+	UCHL1	chr4	41265246	+
intron-intron	ENST00000515785	ENST00000504818	LIMCH1	chr4	41361820	+	UCHL1	chr4	41270004	+
intron-intron	ENST00000515785	ENST00000504818	LIMCH1	chr4	41526495	+	UCHL1	chr4	41258610	+
intron-intron	ENST00000515785	ENST00000504818	LIMCH1	chr4	41496623	+	UCHL1	chr4	41258610	+
intron-intron	ENST00000515785	ENST00000508768	LIMCH1	chr4	41362953	+	UCHL1	chr4	41265242	+
intron-intron	ENST00000515785	ENST00000508768	LIMCH1	chr4	41362953	+	UCHL1	chr4	41266120	+
intron-intron	ENST00000515785	ENST00000508768	LIMCH1	chr4	41362957	+	UCHL1	chr4	41265246	+
intron-intron	ENST00000515785	ENST00000508768	LIMCH1	chr4	41361820	+	UCHL1	chr4	41270004	+
intron-intron	ENST00000515785	ENST00000508768	LIMCH1	chr4	41526495	+	UCHL1	chr4	41258610	+
intron-intron	ENST00000515785	ENST00000508768	LIMCH1	chr4	41496623	+	UCHL1	chr4	41258610	+
intron-intron	ENST00000515785	ENST00000512788	LIMCH1	chr4	41362953	+	UCHL1	chr4	41265242	+
intron-intron	ENST00000515785	ENST00000512788	LIMCH1	chr4	41362953	+	UCHL1	chr4	41266120	+
intron-intron	ENST00000515785	ENST00000512788	LIMCH1	chr4	41362957	+	UCHL1	chr4	41265246	+
intron-intron	ENST00000515785	ENST00000512788	LIMCH1	chr4	41361820	+	UCHL1	chr4	41270004	+
intron-intron	ENST00000515785	ENST00000512788	LIMCH1	chr4	41526495	+	UCHL1	chr4	41258610	+
intron-intron	ENST00000515785	ENST00000512788	LIMCH1	chr4	41496623	+	UCHL1	chr4	41258610	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Genomic Features for LIMCH1-UCHL1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
LIMCH1	chr4	41361820	+	UCHL1	chr4	41270003	+	0.026983347	0.9730166
LIMCH1	chr4	41362953	+	UCHL1	chr4	41266119	+	4.69E-05	0.99995303
LIMCH1	chr4	41362953	+	UCHL1	chr4	41265241	+	6.14E-09	1
LIMCH1	chr4	41361820	+	UCHL1	chr4	41270003	+	0.026983347	0.9730166
LIMCH1	chr4	41362953	+	UCHL1	chr4	41266119	+	4.69E-05	0.99995303
LIMCH1	chr4	41362953	+	UCHL1	chr4	41265241	+	6.14E-09	1

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for LIMCH1-UCHL1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr4:41526495/chr4:41258610)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
LIMCH1 Q9UPQ0	.
FUNCTION: Actin stress fibers-associated protein that activates non-muscle myosin IIa. Activates the non-muscle myosin IIa complex by promoting the phosphorylation of its regulatory subunit MRLC/MYL9. Through the activation of non-muscle myosin IIa, positively regulates actin stress fibers assembly and stabilizes focal adhesions. It therefore negatively regulates cell spreading and cell migration. {ECO:0000269\|PubMed:28228547}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

LIMCH1

chr4:41362953

chr4:41265242

ENST00000313860

354_439

1084.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

LIMCH1

chr4:41362953

chr4:41265242

ENST00000313860

782_823

1084.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

LIMCH1

chr4:41362953

chr4:41265242

ENST00000381753

354_439

891.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

LIMCH1

chr4:41362953

chr4:41265242

ENST00000381753

782_823

891.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

LIMCH1

chr4:41362953

chr4:41265242

ENST00000396595

354_439

903.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

LIMCH1

chr4:41362953

chr4:41265242

ENST00000396595

782_823

903.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

LIMCH1

chr4:41362953

chr4:41265242

ENST00000508501

354_439

1057.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

LIMCH1

chr4:41362953

chr4:41265242

ENST00000508501

782_823

1057.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

LIMCH1

chr4:41362953

chr4:41265242

ENST00000511496

354_439

898.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

LIMCH1

chr4:41362953

chr4:41265242

ENST00000511496

782_823

898.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

LIMCH1

chr4:41362953

chr4:41265242

ENST00000512820

354_439

1070.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

LIMCH1

chr4:41362953

chr4:41265242

ENST00000512820

782_823

1070.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

LIMCH1

chr4:41362953

chr4:41265242

ENST00000512946

354_439

1058.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

LIMCH1

chr4:41362953

chr4:41265242

ENST00000512946

782_823

1058.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

LIMCH1

chr4:41362953

chr4:41265242

ENST00000513024

354_439

911.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

LIMCH1

chr4:41362953

chr4:41265242

ENST00000513024

782_823

911.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

LIMCH1

chr4:41362957

chr4:41265246

ENST00000313860

354_439

1084.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

LIMCH1

chr4:41362957

chr4:41265246

ENST00000313860

782_823

1084.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

LIMCH1

chr4:41362957

chr4:41265246

ENST00000381753

354_439

891.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

LIMCH1

chr4:41362957

chr4:41265246

ENST00000381753

782_823

891.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

LIMCH1

chr4:41362957

chr4:41265246

ENST00000396595

354_439

903.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

LIMCH1

chr4:41362957

chr4:41265246

ENST00000396595

782_823

903.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

LIMCH1

chr4:41362957

chr4:41265246

ENST00000508501

354_439

1057.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

LIMCH1

chr4:41362957

chr4:41265246

ENST00000508501

782_823

1057.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

LIMCH1

chr4:41362957

chr4:41265246

ENST00000511496

354_439

898.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

LIMCH1

chr4:41362957

chr4:41265246

ENST00000511496

782_823

898.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

LIMCH1

chr4:41362957

chr4:41265246

ENST00000512820

354_439

1070.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

LIMCH1

chr4:41362957

chr4:41265246

ENST00000512820

782_823

1070.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

LIMCH1

chr4:41362957

chr4:41265246

ENST00000512946

354_439

1058.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

LIMCH1

chr4:41362957

chr4:41265246

ENST00000512946

782_823

1058.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

LIMCH1

chr4:41362957

chr4:41265246

ENST00000513024

354_439

911.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

LIMCH1

chr4:41362957

chr4:41265246

ENST00000513024

782_823

911.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

LIMCH1

chr4:41362953

chr4:41265242

ENST00000313860

1011_1077

1084.0

Domain

LIM zinc-binding

Hgene

LIMCH1

chr4:41362953

chr4:41265242

ENST00000313860

21_125

1084.0

Domain

Calponin-homology (CH)

Hgene

LIMCH1

chr4:41362953

chr4:41265242

ENST00000381753

1011_1077

891.0

Domain

LIM zinc-binding

Hgene

LIMCH1

chr4:41362953

chr4:41265242

ENST00000381753

21_125

891.0

Domain

Calponin-homology (CH)

Hgene

LIMCH1

chr4:41362953

chr4:41265242

ENST00000396595

1011_1077

903.0

Domain

LIM zinc-binding

Hgene

LIMCH1

chr4:41362953

chr4:41265242

ENST00000396595

21_125

903.0

Domain

Calponin-homology (CH)

Hgene

LIMCH1

chr4:41362953

chr4:41265242

ENST00000508501

1011_1077

1057.0

Domain

LIM zinc-binding

Hgene

LIMCH1

chr4:41362953

chr4:41265242

ENST00000508501

21_125

1057.0

Domain

Calponin-homology (CH)

Hgene

LIMCH1

chr4:41362953

chr4:41265242

ENST00000511496

1011_1077

898.0

Domain

LIM zinc-binding

Hgene

LIMCH1

chr4:41362953

chr4:41265242

ENST00000511496

21_125

898.0

Domain

Calponin-homology (CH)

Hgene

LIMCH1

chr4:41362953

chr4:41265242

ENST00000512820

1011_1077

1070.0

Domain

LIM zinc-binding

Hgene

LIMCH1

chr4:41362953

chr4:41265242

ENST00000512820

21_125

1070.0

Domain

Calponin-homology (CH)

Hgene

LIMCH1

chr4:41362953

chr4:41265242

ENST00000512946

1011_1077

1058.0

Domain

LIM zinc-binding

Hgene

LIMCH1

chr4:41362953

chr4:41265242

ENST00000512946

21_125

1058.0

Domain

Calponin-homology (CH)

Hgene

LIMCH1

chr4:41362953

chr4:41265242

ENST00000513024

1011_1077

911.0

Domain

LIM zinc-binding

Hgene

LIMCH1

chr4:41362953

chr4:41265242

ENST00000513024

21_125

911.0

Domain

Calponin-homology (CH)

Hgene

LIMCH1

chr4:41362957

chr4:41265246

ENST00000313860

1011_1077

1084.0

Domain

LIM zinc-binding

Hgene

LIMCH1

chr4:41362957

chr4:41265246

ENST00000313860

21_125

1084.0

Domain

Calponin-homology (CH)

Hgene

LIMCH1

chr4:41362957

chr4:41265246

ENST00000381753

1011_1077

891.0

Domain

LIM zinc-binding

Hgene

LIMCH1

chr4:41362957

chr4:41265246

ENST00000381753

21_125

891.0

Domain

Calponin-homology (CH)

Hgene

LIMCH1

chr4:41362957

chr4:41265246

ENST00000396595

1011_1077

903.0

Domain

LIM zinc-binding

Hgene

LIMCH1

chr4:41362957

chr4:41265246

ENST00000396595

21_125

903.0

Domain

Calponin-homology (CH)

Hgene

LIMCH1

chr4:41362957

chr4:41265246

ENST00000508501

1011_1077

1057.0

Domain

LIM zinc-binding

Hgene

LIMCH1

chr4:41362957

chr4:41265246

ENST00000508501

21_125

1057.0

Domain

Calponin-homology (CH)

Hgene

LIMCH1

chr4:41362957

chr4:41265246

ENST00000511496

1011_1077

898.0

Domain

LIM zinc-binding

Hgene

LIMCH1

chr4:41362957

chr4:41265246

ENST00000511496

21_125

898.0

Domain

Calponin-homology (CH)

Hgene

LIMCH1

chr4:41362957

chr4:41265246

ENST00000512820

1011_1077

1070.0

Domain

LIM zinc-binding

Hgene

LIMCH1

chr4:41362957

chr4:41265246

ENST00000512820

21_125

1070.0

Domain

Calponin-homology (CH)

Hgene

LIMCH1

chr4:41362957

chr4:41265246

ENST00000512946

1011_1077

1058.0

Domain

LIM zinc-binding

Hgene

LIMCH1

chr4:41362957

chr4:41265246

ENST00000512946

21_125

1058.0

Domain

Calponin-homology (CH)

Hgene

LIMCH1

chr4:41362957

chr4:41265246

ENST00000513024

1011_1077

911.0

Domain

LIM zinc-binding

Hgene

LIMCH1

chr4:41362957

chr4:41265246

ENST00000513024

21_125

911.0

Domain

Calponin-homology (CH)

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Fusion Gene Sequence for LIMCH1-UCHL1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for LIMCH1-UCHL1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Still interaction with
Tgene	UCHL1	chr4:41362953	chr4:41265242	ENST00000284440		5	9	211_216	153.0	224.0	ubiquitin
Tgene	UCHL1	chr4:41362953	chr4:41265242	ENST00000503431		6	10	211_216	153.0	224.0	ubiquitin
Tgene	UCHL1	chr4:41362957	chr4:41265246	ENST00000284440		5	9	211_216	153.0	224.0	ubiquitin
Tgene	UCHL1	chr4:41362957	chr4:41265246	ENST00000503431		6	10	211_216	153.0	224.0	ubiquitin

- Lost PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Tgene	UCHL1	chr4:41362953	chr4:41265242	ENST00000284440		5	9	5_10	153.0	224.0	ubiquitin
Tgene	UCHL1	chr4:41362953	chr4:41265242	ENST00000503431		6	10	5_10	153.0	224.0	ubiquitin
Tgene	UCHL1	chr4:41362957	chr4:41265246	ENST00000284440		5	9	5_10	153.0	224.0	ubiquitin
Tgene	UCHL1	chr4:41362957	chr4:41265246	ENST00000503431		6	10	5_10	153.0	224.0	ubiquitin

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for LIMCH1-UCHL1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for LIMCH1-UCHL1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source