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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:LIMK1-TYW1 (FusionGDB2 ID:44717)

Fusion Gene Summary for LIMK1-TYW1

check button Fusion gene summary
Fusion gene informationFusion gene name: LIMK1-TYW1
Fusion gene ID: 44717
HgeneTgene
Gene symbol

LIMK1

TYW1

Gene ID

3984

55253

Gene nameLIM domain kinase 1tRNA-yW synthesizing protein 1 homolog
SynonymsLIMK|LIMK-1RSAFD1|TYW1A|YPL207W
Cytomap

7q11.23

7q11.21

Type of geneprotein-codingprotein-coding
DescriptionLIM domain kinase 1LIM motif-containing protein kinaseS-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase TYW1S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthaseradical S-adenosyl methionine and flavodoxin domain-containing protein 1radical S-adenosyl methionine and flavodoxin
Modification date2020031320200313
UniProtAcc

P53667

.
Ensembl transtripts involved in fusion geneENST00000336180, ENST00000418310, 
ENST00000538333, ENST00000491052, 
ENST00000491969, ENST00000359626, 
Fusion gene scores* DoF score7 X 6 X 4=16811 X 9 X 5=495
# samples 611
** MAII scorelog2(6/168*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/495*10)=-2.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: LIMK1 [Title/Abstract] AND TYW1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointLIMK1(73526328)-TYW1(66489887), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneLIMK1

GO:0006468

protein phosphorylation

17512523|22328514

HgeneLIMK1

GO:0032233

positive regulation of actin filament bundle assembly

17512523

HgeneLIMK1

GO:0051444

negative regulation of ubiquitin-protein transferase activity

17512523


check buttonFusion gene breakpoints across LIMK1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TYW1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-DX-A1L1-01ALIMK1chr7

73526328

+TYW1chr7

66489887

+


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Fusion Gene ORF analysis for LIMK1-TYW1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000336180ENST00000491969LIMK1chr7

73526328

+TYW1chr7

66489887

+
5CDS-intronENST00000418310ENST00000491969LIMK1chr7

73526328

+TYW1chr7

66489887

+
5CDS-intronENST00000538333ENST00000491969LIMK1chr7

73526328

+TYW1chr7

66489887

+
In-frameENST00000336180ENST00000359626LIMK1chr7

73526328

+TYW1chr7

66489887

+
In-frameENST00000418310ENST00000359626LIMK1chr7

73526328

+TYW1chr7

66489887

+
In-frameENST00000538333ENST00000359626LIMK1chr7

73526328

+TYW1chr7

66489887

+
intron-3CDSENST00000491052ENST00000359626LIMK1chr7

73526328

+TYW1chr7

66489887

+
intron-intronENST00000491052ENST00000491969LIMK1chr7

73526328

+TYW1chr7

66489887

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000418310LIMK1chr773526328+ENST00000359626TYW1chr766489887+39251602962939947
ENST00000336180LIMK1chr773526328+ENST00000359626TYW1chr766489887+37841461512798915
ENST00000538333LIMK1chr773526328+ENST00000359626TYW1chr766489887+380214791712816881

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000418310ENST00000359626LIMK1chr773526328+TYW1chr766489887+0.0006451820.9993548
ENST00000336180ENST00000359626LIMK1chr773526328+TYW1chr766489887+0.0006598720.9993401
ENST00000538333ENST00000359626LIMK1chr773526328+TYW1chr766489887+0.0010305610.99896944

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Fusion Genomic Features for LIMK1-TYW1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
LIMK1chr773526328+TYW1chr766489886+6.07E-111
LIMK1chr773526328+TYW1chr766489886+6.07E-111

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for LIMK1-TYW1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:73526328/chr7:66489887)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LIMK1

P53667

.
FUNCTION: Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics. Acts downstream of several Rho family GTPase signal transduction pathways (PubMed:10436159, PubMed:11832213, PubMed:12807904, PubMed:15660133, PubMed:16230460, PubMed:18028908, PubMed:22328514, PubMed:23633677). Activated by upstream kinases including ROCK1, PAK1 and PAK4, which phosphorylate LIMK1 on a threonine residue located in its activation loop (PubMed:10436159). LIMK1 subsequently phosphorylates and inactivates the actin binding/depolymerizing factors cofilin-1/CFL1, cofilin-2/CFL2 and destrin/DSTN, thereby preventing the cleavage of filamentous actin (F-actin), and stabilizing the actin cytoskeleton (PubMed:11832213, PubMed:15660133, PubMed:16230460, PubMed:23633677). In this way LIMK1 regulates several actin-dependent biological processes including cell motility, cell cycle progression, and differentiation (PubMed:11832213, PubMed:15660133, PubMed:16230460, PubMed:23633677). Phosphorylates TPPP on serine residues, thereby promoting microtubule disassembly (PubMed:18028908). Stimulates axonal outgrowth and may be involved in brain development (PubMed:18028908). {ECO:0000269|PubMed:10436159, ECO:0000269|PubMed:11832213, ECO:0000269|PubMed:12807904, ECO:0000269|PubMed:15660133, ECO:0000269|PubMed:16230460, ECO:0000269|PubMed:18028908, ECO:0000269|PubMed:22328514, ECO:0000269|PubMed:23633677}.; FUNCTION: [Isoform 3]: Has a dominant negative effect on actin cytoskeletal changes. Required for atypical chemokine receptor ACKR2-induced phosphorylation of cofilin (CFL1). {ECO:0000269|PubMed:10196227}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLIMK1chr7:73526328chr7:66489887ENST00000336180+1216165_258470648.0DomainPDZ
HgeneLIMK1chr7:73526328chr7:66489887ENST00000336180+121625_75470648.0DomainLIM zinc-binding 1
HgeneLIMK1chr7:73526328chr7:66489887ENST00000336180+121684_137470648.0DomainLIM zinc-binding 2
HgeneLIMK1chr7:73526328chr7:66489887ENST00000538333+1115165_258436614.0DomainPDZ
HgeneLIMK1chr7:73526328chr7:66489887ENST00000538333+111525_75436614.0DomainLIM zinc-binding 1
HgeneLIMK1chr7:73526328chr7:66489887ENST00000538333+111584_137436614.0DomainLIM zinc-binding 2
HgeneLIMK1chr7:73526328chr7:66489887ENST00000336180+1216345_353470648.0Nucleotide bindingATP
HgeneLIMK1chr7:73526328chr7:66489887ENST00000538333+1115345_353436614.0Nucleotide bindingATP
TgeneTYW1chr7:73526328chr7:66489887ENST00000359626516400_644287733.0DomainRadical SAM core

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLIMK1chr7:73526328chr7:66489887ENST00000336180+1216339_604470648.0DomainProtein kinase
HgeneLIMK1chr7:73526328chr7:66489887ENST00000538333+1115339_604436614.0DomainProtein kinase
TgeneTYW1chr7:73526328chr7:66489887ENST0000035962651679_237287733.0DomainFlavodoxin-like
TgeneTYW1chr7:73526328chr7:66489887ENST00000359626516176_208287733.0Nucleotide bindingFMN
TgeneTYW1chr7:73526328chr7:66489887ENST0000035962651685_89287733.0Nucleotide bindingFMN


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Fusion Gene Sequence for LIMK1-TYW1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>44717_44717_1_LIMK1-TYW1_LIMK1_chr7_73526328_ENST00000336180_TYW1_chr7_66489887_ENST00000359626_length(transcript)=3784nt_BP=1461nt
CCCGGCCGCCCCCAGCCCCAGCCCCGCCGGGCCCCGCCCCCCGTCGAGTGCATGAGGTTGACGCTACTTTGTTGCACCTGGAGGGAAGAA
CGTATGGGAGAGGAAGGAAGCGAGTTGCCCGTGTGTGCAAGCTGCGGCCAGAGGATCTATGATGGCCAGTACCTCCAGGCCCTGAACGCG
GACTGGCACGCAGACTGCTTCAGGTGTTGTGACTGCAGTGCCTCCCTGTCGCACCAGTACTATGAGAAGGATGGGCAGCTCTTCTGCAAG
AAGGACTACTGGGCCCGCTATGGCGAGTCCTGCCATGGGTGCTCTGAGCAAATCACCAAGGGACTGGTTATGGTGGCTGGGGAGCTGAAG
TACCACCCCGAGTGTTTCATCTGCCTCACGTGTGGGACCTTTATCGGTGACGGGGACACCTACACGCTGGTGGAGCACTCCAAGCTGTAC
TGCGGGCACTGCTACTACCAGACTGTGGTGACCCCCGTCATCGAGCAGATCCTGCCTGACTCCCCTGGCTCCCACCTGCCCCACACCGTC
ACCCTGGTGTCCATCCCAGCCTCATCTCATGGCAAGCGTGGACTTTCAGTCTCCATTGACCCCCCGCACGGCCCACCGGGCTGTGGCACC
GAGCACTCACACACCGTCCGCGTCCAGGGAGTGGATCCGGGCTGCATGAGCCCAGATGTGAAGAATTCCATCCACGTCGGAGACCGGATC
TTGGAAATCAATGGCACGCCCATCCGAAATGTGCCCCTGGACGAGATTGACCTGCTGATTCAGGAAACCAGCCGCCTGCTCCAGCTGACC
CTCGAGCATGACCCTCACGATACACTGGGCCACGGGCTGGGGCCTGAGACCAGCCCCCTGAGCTCTCCGGCTTATACTCCCAGCGGGGAG
GCGGGCAGCTCTGCCCGGCAGAAACCTGTCTTGAGGAGCTGCAGCATCGACAGGTCTCCGGGCGCTGGCTCACTGGGCTCCCCGGCCTCC
CAGCGCAAGGACCTGGGTCGCTCTGAGTCCCTCCGCGTAGTCTGCCGGCCACACCGCATCTTCCGGCCGTCGGACCTCATCCACGGGGAG
GTGCTGGGCAAGGGCTGCTTCGGCCAGGCTATCAAGGTGACACACCGTGAGACAGGTGAGGTGATGGTGATGAAGGAGCTGATCCGGTTC
GACGAGGAGACCCAGAGGACGTTCCTCAAGGAGGTGAAGGTCATGCGATGCCTGGAACACCCCAACGTGCTCAAGTTCATCGGGGTGCTC
TACAAGGACAAGAGGCTCAACTTCATCACTGAGTACATCAAGGGCGGCACGCTCCGGGGCATCATCAAGAGCATGGACAGCCAGTACCCA
TGGAGCCAGAGAGTGAGCTTTGCCAAGGACATCGCATCAGGGATGGCCTACCTCCACTCCATGAACATCATCCACCGAGACCTCAACTCC
CACAACTGCCTGGTCCGCGAGGAGGAAGAACCCTTTGAGAGCTCCAGTGAAGAAGAGTTTGGTGGTGAGGACCATCAGAGCCTAAATTCC
ATTGTTGATGTTGAAGATTTGGGCAAAATTATGGATCATGTGAAGAAAGAAAAGAGAGAAAAGGAACAGCAGGAAGAGAAGTCTGGTTTG
TTCAGGAACATGGGGAGGAATGAAGATGGTGAAAGAAGAGCTATGATAACTCCTGCTCTCCGAGAAGCCCTTACTAAACAAGGTTATCAG
TTGATTGGGAGCCACTCGGGGGTGAAGCTTTGCAGGTGGACAAAGTCCATGCTCCGAGGGAGAGGAGGTTGTTACAAACACACATTCTAT
GGAATTGAGAGCCATCGCTGCATGGAAACCACCCCGAGCTTGGCGTGTGCTAATAAATGTGTCTTCTGTTGGCGGCACCACACCAACCCC
GTGGGCACTGAGTGGCGGTGGAAGATGGACCAGCCTGAAATGATCTTGAAGGAAGCCATTGAAAACCATCAGAACATGATTAAGCAGTTT
AAAGGAGTACCGGGCGTCAAAGCAGAACGCTTTGAAGAAGGAATGACGGTAAAGCACTGTGCATTGTCCCTCGTGGGAGAACCAATAATG
TACCCAGAGATCAACAGGTTTTTGAAGCTACTCCACCAGTGTAAAATTTCCAGCTTCCTGGTCACAAACGCACAATTTCCTGCGGAAATC
AGGAACCTCGAGCCGGTTACTCAGCTGTATGTCAGTGTGGATGCCAGTACCAAAGACAGCCTGAAGAAAATCGACCGCCCACTCTTCAAG
GATTTCTGGCAGAGATTCCTTGACAGTTTAAAAGCCTTGGCAGTCAAGCAACAACGAACTGTCTACAGACTGACGCTCGTGAAAGCATGG
AACGTGGACGAGCTCCAGGCCTACGCGCAGCTCGTGTCCCTGGGGAATCCTGACTTCATCGAAGTGAAGGGCGTTACCTACTGCGGAGAA
AGTTCAGCAAGCAGTCTTACCATGGCCCACGTGCCCTGGCATGAGGAAGTGGTACAGTTTGTCCACGAGTTGGTGGATCTGATCCCCGAA
TATGAAATTGCATGTGAACACGAACACTCTAATTGCCTCCTGATAGCACACAGAAAGTTTAAAATTGGTGGTGAATGGTGGACATGGATC
GATTATAACCGCTTCCAGGAGCTCATCCAGGAATATGAAGATAGTGGTGGATCAAAAACGTTCAGCGCAAAGGATTATATGGCCAGAACT
CCTCACTGGGCATTATTTGGTGCCAGTGAAAGAGGCTTTGATCCCAAGGACACAAGACATCAGAGAAAGAACAAATCAAAGGCTATTTCT
GGATGTTGAGATTATCTGATTTCAAGGTACTGAAGGACAAAAACTTGGATGGCCTCAAAAGGTTCTTGAACACCACTGTGATTCTCCAAG
GACGAATTACGTAAATTATACTTTCATACAAAGGAGACGATAAGGCAGTAAACATGGAGACACGGGGGACAGCGTCCACACTCAGAGGGC
CTGGGCCACAGCCCCGATGTTTCTTTTCAGAACTCAGCCCCTTTCCTGATTTTACTTCTAAGAGGAAAATTATTTTGGGGAGGAACTACA
CAGTCGTGATTAGAATTTATCTGATGGTTTTGTATTATAACTTGTAAGACCTGCCAGAATGCTAGTCCCGAGAGTGTCAGACAAGGAAGA
AGTCCCTGGGCCTCTTCCCCTTACCCGGCCCTTAGATTTCATGGAGCAGCCACTTAGCATTGAATTGCACTACCCTGAGCTAAACGTGTC
TGTGCTTTCTAAGATAAGAGCTTGATCCCTTTCTTCTATCTTAAGACAGCACCTCCTGAAAAGAATCGAAGTTGTCACAACTCTCAATTA
TTTTTTAAATACTGCATAGATTGAGTTTTGGTTTATTACCAACCCTTCCCAGAATTGCGTTGGATCTAAAACTACTAGATCTCATCCCAT
TCCCATGTAAATTACCACAGACCGCAGTACCGGGGCTGGAGCGGAGTGAAGCTGTCTGCTGTAAGAGGAGTGGCCATGTGAGGGCATGGA
GTCATTAGTCTCACAAACACACTTTGGACTGAAGAGGATCATTTCTTTTTGTTCGTGAGGTCACTGTCCAGGCCTCTCATATCATGACCA
GACGGCGGGTCTCCATCTTCTTTCACTCCTGTGGCCCTGGCTGCTTTACACAATCTGTTCTATAAGGTTCAGGTGTTTTCAAGTTGGAAA
GATCATAAATACTCAAAATTGTTTTCAAGTTAGCAAGTTCTTTTAACAGTCTTTTATGCAAAAATTGAATTAATAAAATAATCTTTTGTA

>44717_44717_1_LIMK1-TYW1_LIMK1_chr7_73526328_ENST00000336180_TYW1_chr7_66489887_ENST00000359626_length(amino acids)=915AA_BP=470
MRLTLLCCTWREERMGEEGSELPVCASCGQRIYDGQYLQALNADWHADCFRCCDCSASLSHQYYEKDGQLFCKKDYWARYGESCHGCSEQ
ITKGLVMVAGELKYHPECFICLTCGTFIGDGDTYTLVEHSKLYCGHCYYQTVVTPVIEQILPDSPGSHLPHTVTLVSIPASSHGKRGLSV
SIDPPHGPPGCGTEHSHTVRVQGVDPGCMSPDVKNSIHVGDRILEINGTPIRNVPLDEIDLLIQETSRLLQLTLEHDPHDTLGHGLGPET
SPLSSPAYTPSGEAGSSARQKPVLRSCSIDRSPGAGSLGSPASQRKDLGRSESLRVVCRPHRIFRPSDLIHGEVLGKGCFGQAIKVTHRE
TGEVMVMKELIRFDEETQRTFLKEVKVMRCLEHPNVLKFIGVLYKDKRLNFITEYIKGGTLRGIIKSMDSQYPWSQRVSFAKDIASGMAY
LHSMNIIHRDLNSHNCLVREEEEPFESSSEEEFGGEDHQSLNSIVDVEDLGKIMDHVKKEKREKEQQEEKSGLFRNMGRNEDGERRAMIT
PALREALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDQPEMILK
EAIENHQNMIKQFKGVPGVKAERFEEGMTVKHCALSLVGEPIMYPEINRFLKLLHQCKISSFLVTNAQFPAEIRNLEPVTQLYVSVDAST
KDSLKKIDRPLFKDFWQRFLDSLKALAVKQQRTVYRLTLVKAWNVDELQAYAQLVSLGNPDFIEVKGVTYCGESSASSLTMAHVPWHEEV
VQFVHELVDLIPEYEIACEHEHSNCLLIAHRKFKIGGEWWTWIDYNRFQELIQEYEDSGGSKTFSAKDYMARTPHWALFGASERGFDPKD

--------------------------------------------------------------
>44717_44717_2_LIMK1-TYW1_LIMK1_chr7_73526328_ENST00000418310_TYW1_chr7_66489887_ENST00000359626_length(transcript)=3925nt_BP=1602nt
ACTGGGTTCACGTGGGCACGTGGCTCCACTCCGGTCACTGCTTCCTGGGCAGAGGGATGACGTGGAAGGTAGACCTAGGGGGGACAGGGT
TGCTTCCTGCCCATGTCCAGCATTCTAGAATTGTCCACATCTAGGCAGGGCGTTCCACCATCAGTGCTGGACTGGACCACCCAATTCCTT
TGGACGCTTGACTCAGCCCAAACCCGTGCTCCCTCCAGGACCCTGGGCAGGGCAGCCCCAGCTCCAGGAAGCGAGTTGCCCGTGTGTGCA
AGCTGCGGCCAGAGGATCTATGATGGCCAGTACCTCCAGGCCCTGAACGCGGACTGGCACGCAGACTGCTTCAGGTGTTGTGACTGCAGT
GCCTCCCTGTCGCACCAGTACTATGAGAAGGATGGGCAGCTCTTCTGCAAGAAGGACTACTGGGCCCGCTATGGCGAGTCCTGCCATGGG
TGCTCTGAGCAAATCACCAAGGGACTGGTTATGGTGGCTGGGGAGCTGAAGTACCACCCCGAGTGTTTCATCTGCCTCACGTGTGGGACC
TTTATCGGTGACGGGGACACCTACACGCTGGTGGAGCACTCCAAGCTGTACTGCGGGCACTGCTACTACCAGACTGTGGTGACCCCCGTC
ATCGAGCAGATCCTGCCTGACTCCCCTGGCTCCCACCTGCCCCACACCGTCACCCTGGTGTCCATCCCAGCCTCATCTCATGGCAAGCGT
GGACTTTCAGTCTCCATTGACCCCCCGCACGGCCCACCGGGCTGTGGCACCGAGCACTCACACACCGTCCGCGTCCAGGGAGTGGATCCG
GGCTGCATGAGCCCAGATGTGAAGAATTCCATCCACGTCGGAGACCGGATCTTGGAAATCAATGGCACGCCCATCCGAAATGTGCCCCTG
GACGAGATTGACCTGCTGATTCAGGAAACCAGCCGCCTGCTCCAGCTGACCCTCGAGCATGACCCTCACGATACACTGGGCCACGGGCTG
GGGCCTGAGACCAGCCCCCTGAGCTCTCCGGCTTATACTCCCAGCGGGGAGGCGGGCAGCTCTGCCCGGCAGAAACCTGTCTTGAGGAGC
TGCAGCATCGACAGGTCTCCGGGCGCTGGCTCACTGGGCTCCCCGGCCTCCCAGCGCAAGGACCTGGGTCGCTCTGAGTCCCTCCGCGTA
GTCTGCCGGCCACACCGCATCTTCCGGCCGTCGGACCTCATCCACGGGGAGGTGCTGGGCAAGGGCTGCTTCGGCCAGGCTATCAAGGTG
ACACACCGTGAGACAGGTGAGGTGATGGTGATGAAGGAGCTGATCCGGTTCGACGAGGAGACCCAGAGGACGTTCCTCAAGGAGGTGAAG
GTCATGCGATGCCTGGAACACCCCAACGTGCTCAAGTTCATCGGGGTGCTCTACAAGGACAAGAGGCTCAACTTCATCACTGAGTACATC
AAGGGCGGCACGCTCCGGGGCATCATCAAGAGCATGGACAGCCAGTACCCATGGAGCCAGAGAGTGAGCTTTGCCAAGGACATCGCATCA
GGGATGGCCTACCTCCACTCCATGAACATCATCCACCGAGACCTCAACTCCCACAACTGCCTGGTCCGCGAGGAGGAAGAACCCTTTGAG
AGCTCCAGTGAAGAAGAGTTTGGTGGTGAGGACCATCAGAGCCTAAATTCCATTGTTGATGTTGAAGATTTGGGCAAAATTATGGATCAT
GTGAAGAAAGAAAAGAGAGAAAAGGAACAGCAGGAAGAGAAGTCTGGTTTGTTCAGGAACATGGGGAGGAATGAAGATGGTGAAAGAAGA
GCTATGATAACTCCTGCTCTCCGAGAAGCCCTTACTAAACAAGGTTATCAGTTGATTGGGAGCCACTCGGGGGTGAAGCTTTGCAGGTGG
ACAAAGTCCATGCTCCGAGGGAGAGGAGGTTGTTACAAACACACATTCTATGGAATTGAGAGCCATCGCTGCATGGAAACCACCCCGAGC
TTGGCGTGTGCTAATAAATGTGTCTTCTGTTGGCGGCACCACACCAACCCCGTGGGCACTGAGTGGCGGTGGAAGATGGACCAGCCTGAA
ATGATCTTGAAGGAAGCCATTGAAAACCATCAGAACATGATTAAGCAGTTTAAAGGAGTACCGGGCGTCAAAGCAGAACGCTTTGAAGAA
GGAATGACGGTAAAGCACTGTGCATTGTCCCTCGTGGGAGAACCAATAATGTACCCAGAGATCAACAGGTTTTTGAAGCTACTCCACCAG
TGTAAAATTTCCAGCTTCCTGGTCACAAACGCACAATTTCCTGCGGAAATCAGGAACCTCGAGCCGGTTACTCAGCTGTATGTCAGTGTG
GATGCCAGTACCAAAGACAGCCTGAAGAAAATCGACCGCCCACTCTTCAAGGATTTCTGGCAGAGATTCCTTGACAGTTTAAAAGCCTTG
GCAGTCAAGCAACAACGAACTGTCTACAGACTGACGCTCGTGAAAGCATGGAACGTGGACGAGCTCCAGGCCTACGCGCAGCTCGTGTCC
CTGGGGAATCCTGACTTCATCGAAGTGAAGGGCGTTACCTACTGCGGAGAAAGTTCAGCAAGCAGTCTTACCATGGCCCACGTGCCCTGG
CATGAGGAAGTGGTACAGTTTGTCCACGAGTTGGTGGATCTGATCCCCGAATATGAAATTGCATGTGAACACGAACACTCTAATTGCCTC
CTGATAGCACACAGAAAGTTTAAAATTGGTGGTGAATGGTGGACATGGATCGATTATAACCGCTTCCAGGAGCTCATCCAGGAATATGAA
GATAGTGGTGGATCAAAAACGTTCAGCGCAAAGGATTATATGGCCAGAACTCCTCACTGGGCATTATTTGGTGCCAGTGAAAGAGGCTTT
GATCCCAAGGACACAAGACATCAGAGAAAGAACAAATCAAAGGCTATTTCTGGATGTTGAGATTATCTGATTTCAAGGTACTGAAGGACA
AAAACTTGGATGGCCTCAAAAGGTTCTTGAACACCACTGTGATTCTCCAAGGACGAATTACGTAAATTATACTTTCATACAAAGGAGACG
ATAAGGCAGTAAACATGGAGACACGGGGGACAGCGTCCACACTCAGAGGGCCTGGGCCACAGCCCCGATGTTTCTTTTCAGAACTCAGCC
CCTTTCCTGATTTTACTTCTAAGAGGAAAATTATTTTGGGGAGGAACTACACAGTCGTGATTAGAATTTATCTGATGGTTTTGTATTATA
ACTTGTAAGACCTGCCAGAATGCTAGTCCCGAGAGTGTCAGACAAGGAAGAAGTCCCTGGGCCTCTTCCCCTTACCCGGCCCTTAGATTT
CATGGAGCAGCCACTTAGCATTGAATTGCACTACCCTGAGCTAAACGTGTCTGTGCTTTCTAAGATAAGAGCTTGATCCCTTTCTTCTAT
CTTAAGACAGCACCTCCTGAAAAGAATCGAAGTTGTCACAACTCTCAATTATTTTTTAAATACTGCATAGATTGAGTTTTGGTTTATTAC
CAACCCTTCCCAGAATTGCGTTGGATCTAAAACTACTAGATCTCATCCCATTCCCATGTAAATTACCACAGACCGCAGTACCGGGGCTGG
AGCGGAGTGAAGCTGTCTGCTGTAAGAGGAGTGGCCATGTGAGGGCATGGAGTCATTAGTCTCACAAACACACTTTGGACTGAAGAGGAT
CATTTCTTTTTGTTCGTGAGGTCACTGTCCAGGCCTCTCATATCATGACCAGACGGCGGGTCTCCATCTTCTTTCACTCCTGTGGCCCTG
GCTGCTTTACACAATCTGTTCTATAAGGTTCAGGTGTTTTCAAGTTGGAAAGATCATAAATACTCAAAATTGTTTTCAAGTTAGCAAGTT

>44717_44717_2_LIMK1-TYW1_LIMK1_chr7_73526328_ENST00000418310_TYW1_chr7_66489887_ENST00000359626_length(amino acids)=947AA_BP=502
MPMSSILELSTSRQGVPPSVLDWTTQFLWTLDSAQTRAPSRTLGRAAPAPGSELPVCASCGQRIYDGQYLQALNADWHADCFRCCDCSAS
LSHQYYEKDGQLFCKKDYWARYGESCHGCSEQITKGLVMVAGELKYHPECFICLTCGTFIGDGDTYTLVEHSKLYCGHCYYQTVVTPVIE
QILPDSPGSHLPHTVTLVSIPASSHGKRGLSVSIDPPHGPPGCGTEHSHTVRVQGVDPGCMSPDVKNSIHVGDRILEINGTPIRNVPLDE
IDLLIQETSRLLQLTLEHDPHDTLGHGLGPETSPLSSPAYTPSGEAGSSARQKPVLRSCSIDRSPGAGSLGSPASQRKDLGRSESLRVVC
RPHRIFRPSDLIHGEVLGKGCFGQAIKVTHRETGEVMVMKELIRFDEETQRTFLKEVKVMRCLEHPNVLKFIGVLYKDKRLNFITEYIKG
GTLRGIIKSMDSQYPWSQRVSFAKDIASGMAYLHSMNIIHRDLNSHNCLVREEEEPFESSSEEEFGGEDHQSLNSIVDVEDLGKIMDHVK
KEKREKEQQEEKSGLFRNMGRNEDGERRAMITPALREALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLA
CANKCVFCWRHHTNPVGTEWRWKMDQPEMILKEAIENHQNMIKQFKGVPGVKAERFEEGMTVKHCALSLVGEPIMYPEINRFLKLLHQCK
ISSFLVTNAQFPAEIRNLEPVTQLYVSVDASTKDSLKKIDRPLFKDFWQRFLDSLKALAVKQQRTVYRLTLVKAWNVDELQAYAQLVSLG
NPDFIEVKGVTYCGESSASSLTMAHVPWHEEVVQFVHELVDLIPEYEIACEHEHSNCLLIAHRKFKIGGEWWTWIDYNRFQELIQEYEDS

--------------------------------------------------------------
>44717_44717_3_LIMK1-TYW1_LIMK1_chr7_73526328_ENST00000538333_TYW1_chr7_66489887_ENST00000359626_length(transcript)=3802nt_BP=1479nt
AAGTCCCCTGGCACCCACGCGGCTGCAGCCTCCTCCTGTGCGCTGCAGCCACGCTGGCCCCACCCTCTGCAGCCTCCAATCCTGAGCCCC
TGAGGGAGGATGGGGAAGCAGCTGGTCTGGCCACCCCTGCCCTCCCTTAGACCTCCAGAGCCCCCAGTGTAGCCACAGAGGATGCTGTTG
GCTTCAGCCCCAAGAAGACGCCGCTTCCTCCAGAGGGCTAAGTGTTGTGACTGCAGTGCCTCCCTGTCGCACCAGTACTATGAGAAGGAT
GGGCAGCTCTTCTGCAAGAAGGACTACTGGGCCCGCTATGGCGAGTCCTGCCATGGGTGCTCTGAGCAAATCACCAAGGGACTGGTTATG
GTGGCTGGGGAGCTGAAGTACCACCCCGAGTGTTTCATCTGCCTCACGTGTGGGACCTTTATCGGTGACGGGGACACCTACACGCTGGTG
GAGCACTCCAAGCTGTACTGCGGGCACTGCTACTACCAGACTGTGGTGACCCCCGTCATCGAGCAGATCCTGCCTGACTCCCCTGGCTCC
CACCTGCCCCACACCGTCACCCTGGTGTCCATCCCAGCCTCATCTCATGGCAAGCGTGGACTTTCAGTCTCCATTGACCCCCCGCACGGC
CCACCGGGCTGTGGCACCGAGCACTCACACACCGTCCGCGTCCAGGGAGTGGATCCGGGCTGCATGAGCCCAGATGTGAAGAATTCCATC
CACGTCGGAGACCGGATCTTGGAAATCAATGGCACGCCCATCCGAAATGTGCCCCTGGACGAGATTGACCTGCTGATTCAGGAAACCAGC
CGCCTGCTCCAGCTGACCCTCGAGCATGACCCTCACGATACACTGGGCCACGGGCTGGGGCCTGAGACCAGCCCCCTGAGCTCTCCGGCT
TATACTCCCAGCGGGGAGGCGGGCAGCTCTGCCCGGCAGAAACCTGTCTTGAGGAGCTGCAGCATCGACAGGTCTCCGGGCGCTGGCTCA
CTGGGCTCCCCGGCCTCCCAGCGCAAGGACCTGGGTCGCTCTGAGTCCCTCCGCGTAGTCTGCCGGCCACACCGCATCTTCCGGCCGTCG
GACCTCATCCACGGGGAGGTGCTGGGCAAGGGCTGCTTCGGCCAGGCTATCAAGGTGACACACCGTGAGACAGGTGAGGTGATGGTGATG
AAGGAGCTGATCCGGTTCGACGAGGAGACCCAGAGGACGTTCCTCAAGGAGGTGAAGGTCATGCGATGCCTGGAACACCCCAACGTGCTC
AAGTTCATCGGGGTGCTCTACAAGGACAAGAGGCTCAACTTCATCACTGAGTACATCAAGGGCGGCACGCTCCGGGGCATCATCAAGAGC
ATGGACAGCCAGTACCCATGGAGCCAGAGAGTGAGCTTTGCCAAGGACATCGCATCAGGGATGGCCTACCTCCACTCCATGAACATCATC
CACCGAGACCTCAACTCCCACAACTGCCTGGTCCGCGAGGAGGAAGAACCCTTTGAGAGCTCCAGTGAAGAAGAGTTTGGTGGTGAGGAC
CATCAGAGCCTAAATTCCATTGTTGATGTTGAAGATTTGGGCAAAATTATGGATCATGTGAAGAAAGAAAAGAGAGAAAAGGAACAGCAG
GAAGAGAAGTCTGGTTTGTTCAGGAACATGGGGAGGAATGAAGATGGTGAAAGAAGAGCTATGATAACTCCTGCTCTCCGAGAAGCCCTT
ACTAAACAAGGTTATCAGTTGATTGGGAGCCACTCGGGGGTGAAGCTTTGCAGGTGGACAAAGTCCATGCTCCGAGGGAGAGGAGGTTGT
TACAAACACACATTCTATGGAATTGAGAGCCATCGCTGCATGGAAACCACCCCGAGCTTGGCGTGTGCTAATAAATGTGTCTTCTGTTGG
CGGCACCACACCAACCCCGTGGGCACTGAGTGGCGGTGGAAGATGGACCAGCCTGAAATGATCTTGAAGGAAGCCATTGAAAACCATCAG
AACATGATTAAGCAGTTTAAAGGAGTACCGGGCGTCAAAGCAGAACGCTTTGAAGAAGGAATGACGGTAAAGCACTGTGCATTGTCCCTC
GTGGGAGAACCAATAATGTACCCAGAGATCAACAGGTTTTTGAAGCTACTCCACCAGTGTAAAATTTCCAGCTTCCTGGTCACAAACGCA
CAATTTCCTGCGGAAATCAGGAACCTCGAGCCGGTTACTCAGCTGTATGTCAGTGTGGATGCCAGTACCAAAGACAGCCTGAAGAAAATC
GACCGCCCACTCTTCAAGGATTTCTGGCAGAGATTCCTTGACAGTTTAAAAGCCTTGGCAGTCAAGCAACAACGAACTGTCTACAGACTG
ACGCTCGTGAAAGCATGGAACGTGGACGAGCTCCAGGCCTACGCGCAGCTCGTGTCCCTGGGGAATCCTGACTTCATCGAAGTGAAGGGC
GTTACCTACTGCGGAGAAAGTTCAGCAAGCAGTCTTACCATGGCCCACGTGCCCTGGCATGAGGAAGTGGTACAGTTTGTCCACGAGTTG
GTGGATCTGATCCCCGAATATGAAATTGCATGTGAACACGAACACTCTAATTGCCTCCTGATAGCACACAGAAAGTTTAAAATTGGTGGT
GAATGGTGGACATGGATCGATTATAACCGCTTCCAGGAGCTCATCCAGGAATATGAAGATAGTGGTGGATCAAAAACGTTCAGCGCAAAG
GATTATATGGCCAGAACTCCTCACTGGGCATTATTTGGTGCCAGTGAAAGAGGCTTTGATCCCAAGGACACAAGACATCAGAGAAAGAAC
AAATCAAAGGCTATTTCTGGATGTTGAGATTATCTGATTTCAAGGTACTGAAGGACAAAAACTTGGATGGCCTCAAAAGGTTCTTGAACA
CCACTGTGATTCTCCAAGGACGAATTACGTAAATTATACTTTCATACAAAGGAGACGATAAGGCAGTAAACATGGAGACACGGGGGACAG
CGTCCACACTCAGAGGGCCTGGGCCACAGCCCCGATGTTTCTTTTCAGAACTCAGCCCCTTTCCTGATTTTACTTCTAAGAGGAAAATTA
TTTTGGGGAGGAACTACACAGTCGTGATTAGAATTTATCTGATGGTTTTGTATTATAACTTGTAAGACCTGCCAGAATGCTAGTCCCGAG
AGTGTCAGACAAGGAAGAAGTCCCTGGGCCTCTTCCCCTTACCCGGCCCTTAGATTTCATGGAGCAGCCACTTAGCATTGAATTGCACTA
CCCTGAGCTAAACGTGTCTGTGCTTTCTAAGATAAGAGCTTGATCCCTTTCTTCTATCTTAAGACAGCACCTCCTGAAAAGAATCGAAGT
TGTCACAACTCTCAATTATTTTTTAAATACTGCATAGATTGAGTTTTGGTTTATTACCAACCCTTCCCAGAATTGCGTTGGATCTAAAAC
TACTAGATCTCATCCCATTCCCATGTAAATTACCACAGACCGCAGTACCGGGGCTGGAGCGGAGTGAAGCTGTCTGCTGTAAGAGGAGTG
GCCATGTGAGGGCATGGAGTCATTAGTCTCACAAACACACTTTGGACTGAAGAGGATCATTTCTTTTTGTTCGTGAGGTCACTGTCCAGG
CCTCTCATATCATGACCAGACGGCGGGTCTCCATCTTCTTTCACTCCTGTGGCCCTGGCTGCTTTACACAATCTGTTCTATAAGGTTCAG
GTGTTTTCAAGTTGGAAAGATCATAAATACTCAAAATTGTTTTCAAGTTAGCAAGTTCTTTTAACAGTCTTTTATGCAAAAATTGAATTA

>44717_44717_3_LIMK1-TYW1_LIMK1_chr7_73526328_ENST00000538333_TYW1_chr7_66489887_ENST00000359626_length(amino acids)=881AA_BP=436
MLLASAPRRRRFLQRAKCCDCSASLSHQYYEKDGQLFCKKDYWARYGESCHGCSEQITKGLVMVAGELKYHPECFICLTCGTFIGDGDTY
TLVEHSKLYCGHCYYQTVVTPVIEQILPDSPGSHLPHTVTLVSIPASSHGKRGLSVSIDPPHGPPGCGTEHSHTVRVQGVDPGCMSPDVK
NSIHVGDRILEINGTPIRNVPLDEIDLLIQETSRLLQLTLEHDPHDTLGHGLGPETSPLSSPAYTPSGEAGSSARQKPVLRSCSIDRSPG
AGSLGSPASQRKDLGRSESLRVVCRPHRIFRPSDLIHGEVLGKGCFGQAIKVTHRETGEVMVMKELIRFDEETQRTFLKEVKVMRCLEHP
NVLKFIGVLYKDKRLNFITEYIKGGTLRGIIKSMDSQYPWSQRVSFAKDIASGMAYLHSMNIIHRDLNSHNCLVREEEEPFESSSEEEFG
GEDHQSLNSIVDVEDLGKIMDHVKKEKREKEQQEEKSGLFRNMGRNEDGERRAMITPALREALTKQGYQLIGSHSGVKLCRWTKSMLRGR
GGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDQPEMILKEAIENHQNMIKQFKGVPGVKAERFEEGMTVKHCA
LSLVGEPIMYPEINRFLKLLHQCKISSFLVTNAQFPAEIRNLEPVTQLYVSVDASTKDSLKKIDRPLFKDFWQRFLDSLKALAVKQQRTV
YRLTLVKAWNVDELQAYAQLVSLGNPDFIEVKGVTYCGESSASSLTMAHVPWHEEVVQFVHELVDLIPEYEIACEHEHSNCLLIAHRKFK

--------------------------------------------------------------

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Fusion Gene PPI Analysis for LIMK1-TYW1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for LIMK1-TYW1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for LIMK1-TYW1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource