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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:LIMK2-ATXN10 (FusionGDB2 ID:44719)

Fusion Gene Summary for LIMK2-ATXN10

check button Fusion gene summary
Fusion gene informationFusion gene name: LIMK2-ATXN10
Fusion gene ID: 44719
HgeneTgene
Gene symbol

LIMK2

ATXN10

Gene ID

3985

25814

Gene nameLIM domain kinase 2ataxin 10
Synonyms-E46L|HUMEEP|SCA10
Cytomap

22q12.2

22q13.31

Type of geneprotein-codingprotein-coding
DescriptionLIM domain kinase 2ataxin-10brain protein E46 homologspinocerebellar ataxia type 10 protein
Modification date2020031320200313
UniProtAcc.

Q9UBB4

Ensembl transtripts involved in fusion geneENST00000331728, ENST00000333611, 
ENST00000340552, ENST00000406516, 
ENST00000444929, ENST00000467301, 
ENST00000402380, ENST00000498009, 
ENST00000252934, ENST00000381061, 
Fusion gene scores* DoF score11 X 7 X 7=53924 X 19 X 12=5472
# samples 1328
** MAII scorelog2(13/539*10)=-2.05177364972405
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(28/5472*10)=-4.28856949794093
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: LIMK2 [Title/Abstract] AND ATXN10 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointLIMK2(31654412)-ATXN10(46202839), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneLIMK2

GO:0006468

protein phosphorylation

22328514

HgeneLIMK2

GO:0030953

astral microtubule organization

22328514

TgeneATXN10

GO:0031175

neuron projection development

16498633


check buttonFusion gene breakpoints across LIMK2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ATXN10 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4HNSCTCGA-CV-6941-01ALIMK2chr22

31654412

-ATXN10chr22

46202839

+
ChimerDB4HNSCTCGA-CV-6941-01ALIMK2chr22

31654412

+ATXN10chr22

46202839

+
ChimerDB4HNSCTCGA-CV-6941LIMK2chr22

31654412

+ATXN10chr22

46202839

+


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Fusion Gene ORF analysis for LIMK2-ATXN10

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000331728ENST00000402380LIMK2chr22

31654412

+ATXN10chr22

46202839

+
5CDS-intronENST00000331728ENST00000498009LIMK2chr22

31654412

+ATXN10chr22

46202839

+
5CDS-intronENST00000333611ENST00000402380LIMK2chr22

31654412

+ATXN10chr22

46202839

+
5CDS-intronENST00000333611ENST00000498009LIMK2chr22

31654412

+ATXN10chr22

46202839

+
5CDS-intronENST00000340552ENST00000402380LIMK2chr22

31654412

+ATXN10chr22

46202839

+
5CDS-intronENST00000340552ENST00000498009LIMK2chr22

31654412

+ATXN10chr22

46202839

+
5CDS-intronENST00000406516ENST00000402380LIMK2chr22

31654412

+ATXN10chr22

46202839

+
5CDS-intronENST00000406516ENST00000498009LIMK2chr22

31654412

+ATXN10chr22

46202839

+
In-frameENST00000331728ENST00000252934LIMK2chr22

31654412

+ATXN10chr22

46202839

+
In-frameENST00000331728ENST00000381061LIMK2chr22

31654412

+ATXN10chr22

46202839

+
In-frameENST00000333611ENST00000252934LIMK2chr22

31654412

+ATXN10chr22

46202839

+
In-frameENST00000333611ENST00000381061LIMK2chr22

31654412

+ATXN10chr22

46202839

+
In-frameENST00000340552ENST00000252934LIMK2chr22

31654412

+ATXN10chr22

46202839

+
In-frameENST00000340552ENST00000381061LIMK2chr22

31654412

+ATXN10chr22

46202839

+
In-frameENST00000406516ENST00000252934LIMK2chr22

31654412

+ATXN10chr22

46202839

+
In-frameENST00000406516ENST00000381061LIMK2chr22

31654412

+ATXN10chr22

46202839

+
intron-3CDSENST00000444929ENST00000252934LIMK2chr22

31654412

+ATXN10chr22

46202839

+
intron-3CDSENST00000444929ENST00000381061LIMK2chr22

31654412

+ATXN10chr22

46202839

+
intron-3CDSENST00000467301ENST00000252934LIMK2chr22

31654412

+ATXN10chr22

46202839

+
intron-3CDSENST00000467301ENST00000381061LIMK2chr22

31654412

+ATXN10chr22

46202839

+
intron-intronENST00000444929ENST00000402380LIMK2chr22

31654412

+ATXN10chr22

46202839

+
intron-intronENST00000444929ENST00000498009LIMK2chr22

31654412

+ATXN10chr22

46202839

+
intron-intronENST00000467301ENST00000402380LIMK2chr22

31654412

+ATXN10chr22

46202839

+
intron-intronENST00000467301ENST00000498009LIMK2chr22

31654412

+ATXN10chr22

46202839

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000406516LIMK2chr2231654412+ENST00000381061ATXN10chr2246202839+217528777541154
ENST00000406516LIMK2chr2231654412+ENST00000252934ATXN10chr2246202839+217828777541154
ENST00000331728LIMK2chr2231654412+ENST00000381061ATXN10chr2246202839+225436666620184
ENST00000331728LIMK2chr2231654412+ENST00000252934ATXN10chr2246202839+225736666620184
ENST00000333611LIMK2chr2231654412+ENST00000381061ATXN10chr2246202839+2392504141758205
ENST00000333611LIMK2chr2231654412+ENST00000252934ATXN10chr2246202839+2395504141758205
ENST00000340552LIMK2chr2231654412+ENST00000381061ATXN10chr2246202839+230741956673205
ENST00000340552LIMK2chr2231654412+ENST00000252934ATXN10chr2246202839+231041956673205

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000406516ENST00000381061LIMK2chr2231654412+ATXN10chr2246202839+0.0378534460.9621465
ENST00000406516ENST00000252934LIMK2chr2231654412+ATXN10chr2246202839+0.0398839820.9601161
ENST00000331728ENST00000381061LIMK2chr2231654412+ATXN10chr2246202839+0.0021589150.9978411
ENST00000331728ENST00000252934LIMK2chr2231654412+ATXN10chr2246202839+0.0021593840.99784064
ENST00000333611ENST00000381061LIMK2chr2231654412+ATXN10chr2246202839+0.0276689940.97233105
ENST00000333611ENST00000252934LIMK2chr2231654412+ATXN10chr2246202839+0.0254880920.97451186
ENST00000340552ENST00000381061LIMK2chr2231654412+ATXN10chr2246202839+0.0447867960.95521325
ENST00000340552ENST00000252934LIMK2chr2231654412+ATXN10chr2246202839+0.044901770.9550983

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Fusion Genomic Features for LIMK2-ATXN10


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
LIMK2chr2231654412+ATXN10chr2246202838+6.73E-050.99993277
LIMK2chr2231654412+ATXN10chr2246202838+6.73E-050.99993277
LIMK2chr2231654412+ATXN10chr2246202838+6.73E-050.99993277
LIMK2chr2231654412+ATXN10chr2246202838+6.73E-050.99993277

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for LIMK2-ATXN10


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr22:31654412/chr22:46202839)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.ATXN10

Q9UBB4

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Necessary for the survival of cerebellar neurons. Induces neuritogenesis by activating the Ras-MAP kinase pathway. May play a role in the maintenance of a critical intracellular glycosylation level and homeostasis. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLIMK2chr22:31654412chr22:46202839ENST00000331728+31612_6384639.0DomainLIM zinc-binding 1
HgeneLIMK2chr22:31654412chr22:46202839ENST00000333611+21512_6363618.0DomainLIM zinc-binding 1
HgeneLIMK2chr22:31654412chr22:46202839ENST00000340552+21512_6363687.0DomainLIM zinc-binding 1

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLIMK2chr22:31654412chr22:46202839ENST00000331728+316152_23984639.0DomainPDZ
HgeneLIMK2chr22:31654412chr22:46202839ENST00000331728+316331_60884639.0DomainProtein kinase
HgeneLIMK2chr22:31654412chr22:46202839ENST00000331728+31672_12484639.0DomainLIM zinc-binding 2
HgeneLIMK2chr22:31654412chr22:46202839ENST00000333611+215152_23963618.0DomainPDZ
HgeneLIMK2chr22:31654412chr22:46202839ENST00000333611+215331_60863618.0DomainProtein kinase
HgeneLIMK2chr22:31654412chr22:46202839ENST00000333611+21572_12463618.0DomainLIM zinc-binding 2
HgeneLIMK2chr22:31654412chr22:46202839ENST00000340552+215152_23963687.0DomainPDZ
HgeneLIMK2chr22:31654412chr22:46202839ENST00000340552+215331_60863687.0DomainProtein kinase
HgeneLIMK2chr22:31654412chr22:46202839ENST00000340552+21572_12463687.0DomainLIM zinc-binding 2
HgeneLIMK2chr22:31654412chr22:46202839ENST00000331728+316337_34584639.0Nucleotide bindingATP
HgeneLIMK2chr22:31654412chr22:46202839ENST00000333611+215337_34563618.0Nucleotide bindingATP
HgeneLIMK2chr22:31654412chr22:46202839ENST00000340552+215337_34563687.0Nucleotide bindingATP


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Fusion Gene Sequence for LIMK2-ATXN10


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>44719_44719_1_LIMK2-ATXN10_LIMK2_chr22_31654412_ENST00000331728_ATXN10_chr22_46202839_ENST00000252934_length(transcript)=2257nt_BP=366nt
GTGGTCTTCCCGCGCCTGAGGCGGCGGCGGCAGGAGCTGAGGGGAGTTGTAGGGAACTGAGGGGAGCTGCTGTGTCCCCCGCCTCCTCCT
CCCCATTTCCGCGCTCCCGGGACCATGTCCGCGCTGGCGGGTGAAGATGTCTGGAGGTGTCCAGGCTGTGGGGACCACATTGCTCCAAGC
CAGATATGGTACAGGACTGTCAACGAAACCTGGCACGGCTCTTGCTTCCGGTGTTCAGAATGCCAGGATTCCCTCACCAACTGGTACTAT
GAGAAGGATGGGAAGCTCTACTGCCCCAAGGACTACTGGGGGAAGTTTGGGGAGTTCTGTCATGGGTGCTCCCTGCTGATGACAGGGCCT
TTTATGGTAAATGAGCTGGATGGTATCCCGTTGATCCTGGACAACTGCAACATCAGTGACAGTAACCCCTTTCTGACCCAGTGGGTGATA
TATGCCATCCGAAACCTTACCGAAGACAACAGCCAAAACCAAGATTTGATTGCAAAGATGGAGGAACAGGGGCTGGCAGATGCATCCCTA
CTTAAAAAAGTGGGTTTTGAAGTTGAAAAGAAAGGCGAAAAGCTGATCCTGAAATCTACTAGAGACACCCCTAAGCCATGAATGAACTAC
ATCCAAATACCTGAATTTTTGGAATCTGTTTCATGGATTTTTCATCTTCTACCGTATGTGAAATTGCAAGTGTTTGAAGATTTATAAGTA
CAAATTTGGGAACATACAAATCTTTTAGGTAGTAGAGTTTAACGTGTATAAGCTAAAAGTGAAAGTAACTGAGTGTTCTCTTGTTTCTTT
GCATTAATGTAACTGTGTGGTTTGCCTTTGTCCCCCTGGATAGAACGTGCATTTAAAGAATATATTGTACTTACTGTGACAGCAGATAAT
AAACCAGTCTCTTGGAGGGCACAACCCTTATTTGACAAAACTTGGATGTTGGCTTGACTGTGTTTGTCCCTTCAGATGGCAAGTCAGCAT
CATTCTTTATATTCCTCTTCTCATTGGGTTTTCTGAACTCTGGCAGGCGGTTGAAGTAGTTTCTCACTGTGATTAATTCTAGCAATCTCT
TTTCACCCCTCTGCCTTTCCAAAACATTGACAAGACTCATTTCCAGTTAATTAATTCGAGAACCCTCCCTCTTCATTTTGGGTACTGGGC
TGTCTTGTCACTGAGCCCTATCCCTTTGGAATGTGGCAGGGAGTGAGGTTGGTGAGAGAACATGTGGGCACTTAACTCTTCATGTTCCAG
TTCATCCCAGAAGTAGACATCCCAGGACCCATTCTGTGTCAAGGTGAATGCCTGTGTCCTCCCCAGCTTCATGCCTCTGTCATGGGGGAA
GGAATAGCTTATGTTCTGCTCTGGTGCAGTGCCGTAGATTAAAGGTACATTTCTATCTTCTTTGATTTAAAAAGCACCAGTCTCATAAAG
GTGCCACTCAGTTTTAGCCATGTCTTCACTGAAATTGCAAAAGTACTTTTAGGGAGCAGGAGTTTATTTGACATCTAGTTATCTGTCTGT
CTGTTCATCTATCTATCTGTCTGCTGTATGAGAGGTAGGACTGGATTAAATGACCACTGAACTCACTGAATCCAGATCATTCATATCATC
AACAAAAGCTCTAGGGGGAGGTCACGTTGTGAATGCTTAAAACATATTATTTTCTTCAACAACCATATCGCTAAACTAATATATCCAGAG
ATTTTGCACAATTCGTGTTGAACCTTCCAAAACAAAAATAAAGACCTGTCCAAAAGTTTTGACAAAAATACTGATTGCTCCCAAATAAAG
TGCTTCTAAGCTTTGTGTAGACATAGTTTAACTGATTTGTAAAAATAGCTTAAGCATGTTGAGAATGAAGTAAAAGTTTTCCCATGTGCT
GTCTAATGTACTCTGTGTAACTCTGAAGACACATCAGCTTCTAGGATTGCAGCAATCTATGAATAACATTTTTTCTCTCATTTATGACTT
TCCATCAGTAAAGAAGCCATTGCAGAATTTAAAATTACACAAAGGAGTCATTCTCTCCTGGGACATAAAGAGTTAAAGCTCTGTCCTCTA
AATAGAAGCCTGGCCAAAGGGAGAAAACAGTGGGAGTCCCTTTTCCCTTTTAACAAGTTTGCAATAGACACTTCTTTTTTTCCTGTCTCA
ATGGATGTGTGCACACCAGTGGAATCGCACAAACTTGTCGGTATGAGCTATATAATAACAAACACAAATAAATAAAAGGGAGCCTTGTGA

>44719_44719_1_LIMK2-ATXN10_LIMK2_chr22_31654412_ENST00000331728_ATXN10_chr22_46202839_ENST00000252934_length(amino acids)=184AA_BP=100
MLCPPPPPPHFRAPGTMSALAGEDVWRCPGCGDHIAPSQIWYRTVNETWHGSCFRCSECQDSLTNWYYEKDGKLYCPKDYWGKFGEFCHG
CSLLMTGPFMVNELDGIPLILDNCNISDSNPFLTQWVIYAIRNLTEDNSQNQDLIAKMEEQGLADASLLKKVGFEVEKKGEKLILKSTRD

--------------------------------------------------------------
>44719_44719_2_LIMK2-ATXN10_LIMK2_chr22_31654412_ENST00000331728_ATXN10_chr22_46202839_ENST00000381061_length(transcript)=2254nt_BP=366nt
GTGGTCTTCCCGCGCCTGAGGCGGCGGCGGCAGGAGCTGAGGGGAGTTGTAGGGAACTGAGGGGAGCTGCTGTGTCCCCCGCCTCCTCCT
CCCCATTTCCGCGCTCCCGGGACCATGTCCGCGCTGGCGGGTGAAGATGTCTGGAGGTGTCCAGGCTGTGGGGACCACATTGCTCCAAGC
CAGATATGGTACAGGACTGTCAACGAAACCTGGCACGGCTCTTGCTTCCGGTGTTCAGAATGCCAGGATTCCCTCACCAACTGGTACTAT
GAGAAGGATGGGAAGCTCTACTGCCCCAAGGACTACTGGGGGAAGTTTGGGGAGTTCTGTCATGGGTGCTCCCTGCTGATGACAGGGCCT
TTTATGGTAAATGAGCTGGATGGTATCCCGTTGATCCTGGACAACTGCAACATCAGTGACAGTAACCCCTTTCTGACCCAGTGGGTGATA
TATGCCATCCGAAACCTTACCGAAGACAACAGCCAAAACCAAGATTTGATTGCAAAGATGGAGGAACAGGGGCTGGCAGATGCATCCCTA
CTTAAAAAAGTGGGTTTTGAAGTTGAAAAGAAAGGCGAAAAGCTGATCCTGAAATCTACTAGAGACACCCCTAAGCCATGAATGAACTAC
ATCCAAATACCTGAATTTTTGGAATCTGTTTCATGGATTTTTCATCTTCTACCGTATGTGAAATTGCAAGTGTTTGAAGATTTATAAGTA
CAAATTTGGGAACATACAAATCTTTTAGGTAGTAGAGTTTAACGTGTATAAGCTAAAAGTGAAAGTAACTGAGTGTTCTCTTGTTTCTTT
GCATTAATGTAACTGTGTGGTTTGCCTTTGTCCCCCTGGATAGAACGTGCATTTAAAGAATATATTGTACTTACTGTGACAGCAGATAAT
AAACCAGTCTCTTGGAGGGCACAACCCTTATTTGACAAAACTTGGATGTTGGCTTGACTGTGTTTGTCCCTTCAGATGGCAAGTCAGCAT
CATTCTTTATATTCCTCTTCTCATTGGGTTTTCTGAACTCTGGCAGGCGGTTGAAGTAGTTTCTCACTGTGATTAATTCTAGCAATCTCT
TTTCACCCCTCTGCCTTTCCAAAACATTGACAAGACTCATTTCCAGTTAATTAATTCGAGAACCCTCCCTCTTCATTTTGGGTACTGGGC
TGTCTTGTCACTGAGCCCTATCCCTTTGGAATGTGGCAGGGAGTGAGGTTGGTGAGAGAACATGTGGGCACTTAACTCTTCATGTTCCAG
TTCATCCCAGAAGTAGACATCCCAGGACCCATTCTGTGTCAAGGTGAATGCCTGTGTCCTCCCCAGCTTCATGCCTCTGTCATGGGGGAA
GGAATAGCTTATGTTCTGCTCTGGTGCAGTGCCGTAGATTAAAGGTACATTTCTATCTTCTTTGATTTAAAAAGCACCAGTCTCATAAAG
GTGCCACTCAGTTTTAGCCATGTCTTCACTGAAATTGCAAAAGTACTTTTAGGGAGCAGGAGTTTATTTGACATCTAGTTATCTGTCTGT
CTGTTCATCTATCTATCTGTCTGCTGTATGAGAGGTAGGACTGGATTAAATGACCACTGAACTCACTGAATCCAGATCATTCATATCATC
AACAAAAGCTCTAGGGGGAGGTCACGTTGTGAATGCTTAAAACATATTATTTTCTTCAACAACCATATCGCTAAACTAATATATCCAGAG
ATTTTGCACAATTCGTGTTGAACCTTCCAAAACAAAAATAAAGACCTGTCCAAAAGTTTTGACAAAAATACTGATTGCTCCCAAATAAAG
TGCTTCTAAGCTTTGTGTAGACATAGTTTAACTGATTTGTAAAAATAGCTTAAGCATGTTGAGAATGAAGTAAAAGTTTTCCCATGTGCT
GTCTAATGTACTCTGTGTAACTCTGAAGACACATCAGCTTCTAGGATTGCAGCAATCTATGAATAACATTTTTTCTCTCATTTATGACTT
TCCATCAGTAAAGAAGCCATTGCAGAATTTAAAATTACACAAAGGAGTCATTCTCTCCTGGGACATAAAGAGTTAAAGCTCTGTCCTCTA
AATAGAAGCCTGGCCAAAGGGAGAAAACAGTGGGAGTCCCTTTTCCCTTTTAACAAGTTTGCAATAGACACTTCTTTTTTTCCTGTCTCA
ATGGATGTGTGCACACCAGTGGAATCGCACAAACTTGTCGGTATGAGCTATATAATAACAAACACAAATAAATAAAAGGGAGCCTTGTGA

>44719_44719_2_LIMK2-ATXN10_LIMK2_chr22_31654412_ENST00000331728_ATXN10_chr22_46202839_ENST00000381061_length(amino acids)=184AA_BP=100
MLCPPPPPPHFRAPGTMSALAGEDVWRCPGCGDHIAPSQIWYRTVNETWHGSCFRCSECQDSLTNWYYEKDGKLYCPKDYWGKFGEFCHG
CSLLMTGPFMVNELDGIPLILDNCNISDSNPFLTQWVIYAIRNLTEDNSQNQDLIAKMEEQGLADASLLKKVGFEVEKKGEKLILKSTRD

--------------------------------------------------------------
>44719_44719_3_LIMK2-ATXN10_LIMK2_chr22_31654412_ENST00000333611_ATXN10_chr22_46202839_ENST00000252934_length(transcript)=2395nt_BP=504nt
CTCAAGAATGCCAGTGTGTGTGTAGCCTCCACAGAGAGGTCGTTTTCTCGGAGTCCAGAGGGGCCGCCTGAGCTTCTGAGAACTAGGGAG
GAGCCATCCCAGCCATGAGCCCCTGTGGGAATCTGCTGGGGGCCAAGTGGCCTGGAGTCCTCAGGCTCCCGCAGCTGCTCCGGAGGGAGA
GGTGAGCTCAGGGCAGCCTGCCTGCAGCCAGAGGTGCCGGGAGCCCCGGGCCTGTCATGGTGGCCATCTACAGCCGGCCTGAGGCAGTCA
CAGACGGATTTGCAGCTGAGCCTGTCTATCTGGTGTGGGAAGAAGATGGGGAGTTACTTGTCAGTCCCGGCTTACTTCACCTCCAGAGAC
CTGTTTCGGTGTTCAGAATGCCAGGATTCCCTCACCAACTGGTACTATGAGAAGGATGGGAAGCTCTACTGCCCCAAGGACTACTGGGGG
AAGTTTGGGGAGTTCTGTCATGGGTGCTCCCTGCTGATGACAGGGCCTTTTATGGTAAATGAGCTGGATGGTATCCCGTTGATCCTGGAC
AACTGCAACATCAGTGACAGTAACCCCTTTCTGACCCAGTGGGTGATATATGCCATCCGAAACCTTACCGAAGACAACAGCCAAAACCAA
GATTTGATTGCAAAGATGGAGGAACAGGGGCTGGCAGATGCATCCCTACTTAAAAAAGTGGGTTTTGAAGTTGAAAAGAAAGGCGAAAAG
CTGATCCTGAAATCTACTAGAGACACCCCTAAGCCATGAATGAACTACATCCAAATACCTGAATTTTTGGAATCTGTTTCATGGATTTTT
CATCTTCTACCGTATGTGAAATTGCAAGTGTTTGAAGATTTATAAGTACAAATTTGGGAACATACAAATCTTTTAGGTAGTAGAGTTTAA
CGTGTATAAGCTAAAAGTGAAAGTAACTGAGTGTTCTCTTGTTTCTTTGCATTAATGTAACTGTGTGGTTTGCCTTTGTCCCCCTGGATA
GAACGTGCATTTAAAGAATATATTGTACTTACTGTGACAGCAGATAATAAACCAGTCTCTTGGAGGGCACAACCCTTATTTGACAAAACT
TGGATGTTGGCTTGACTGTGTTTGTCCCTTCAGATGGCAAGTCAGCATCATTCTTTATATTCCTCTTCTCATTGGGTTTTCTGAACTCTG
GCAGGCGGTTGAAGTAGTTTCTCACTGTGATTAATTCTAGCAATCTCTTTTCACCCCTCTGCCTTTCCAAAACATTGACAAGACTCATTT
CCAGTTAATTAATTCGAGAACCCTCCCTCTTCATTTTGGGTACTGGGCTGTCTTGTCACTGAGCCCTATCCCTTTGGAATGTGGCAGGGA
GTGAGGTTGGTGAGAGAACATGTGGGCACTTAACTCTTCATGTTCCAGTTCATCCCAGAAGTAGACATCCCAGGACCCATTCTGTGTCAA
GGTGAATGCCTGTGTCCTCCCCAGCTTCATGCCTCTGTCATGGGGGAAGGAATAGCTTATGTTCTGCTCTGGTGCAGTGCCGTAGATTAA
AGGTACATTTCTATCTTCTTTGATTTAAAAAGCACCAGTCTCATAAAGGTGCCACTCAGTTTTAGCCATGTCTTCACTGAAATTGCAAAA
GTACTTTTAGGGAGCAGGAGTTTATTTGACATCTAGTTATCTGTCTGTCTGTTCATCTATCTATCTGTCTGCTGTATGAGAGGTAGGACT
GGATTAAATGACCACTGAACTCACTGAATCCAGATCATTCATATCATCAACAAAAGCTCTAGGGGGAGGTCACGTTGTGAATGCTTAAAA
CATATTATTTTCTTCAACAACCATATCGCTAAACTAATATATCCAGAGATTTTGCACAATTCGTGTTGAACCTTCCAAAACAAAAATAAA
GACCTGTCCAAAAGTTTTGACAAAAATACTGATTGCTCCCAAATAAAGTGCTTCTAAGCTTTGTGTAGACATAGTTTAACTGATTTGTAA
AAATAGCTTAAGCATGTTGAGAATGAAGTAAAAGTTTTCCCATGTGCTGTCTAATGTACTCTGTGTAACTCTGAAGACACATCAGCTTCT
AGGATTGCAGCAATCTATGAATAACATTTTTTCTCTCATTTATGACTTTCCATCAGTAAAGAAGCCATTGCAGAATTTAAAATTACACAA
AGGAGTCATTCTCTCCTGGGACATAAAGAGTTAAAGCTCTGTCCTCTAAATAGAAGCCTGGCCAAAGGGAGAAAACAGTGGGAGTCCCTT
TTCCCTTTTAACAAGTTTGCAATAGACACTTCTTTTTTTCCTGTCTCAATGGATGTGTGCACACCAGTGGAATCGCACAAACTTGTCGGT

>44719_44719_3_LIMK2-ATXN10_LIMK2_chr22_31654412_ENST00000333611_ATXN10_chr22_46202839_ENST00000252934_length(amino acids)=205AA_BP=121
MESSGSRSCSGGRGELRAACLQPEVPGAPGLSWWPSTAGLRQSQTDLQLSLSIWCGKKMGSYLSVPAYFTSRDLFRCSECQDSLTNWYYE
KDGKLYCPKDYWGKFGEFCHGCSLLMTGPFMVNELDGIPLILDNCNISDSNPFLTQWVIYAIRNLTEDNSQNQDLIAKMEEQGLADASLL

--------------------------------------------------------------
>44719_44719_4_LIMK2-ATXN10_LIMK2_chr22_31654412_ENST00000333611_ATXN10_chr22_46202839_ENST00000381061_length(transcript)=2392nt_BP=504nt
CTCAAGAATGCCAGTGTGTGTGTAGCCTCCACAGAGAGGTCGTTTTCTCGGAGTCCAGAGGGGCCGCCTGAGCTTCTGAGAACTAGGGAG
GAGCCATCCCAGCCATGAGCCCCTGTGGGAATCTGCTGGGGGCCAAGTGGCCTGGAGTCCTCAGGCTCCCGCAGCTGCTCCGGAGGGAGA
GGTGAGCTCAGGGCAGCCTGCCTGCAGCCAGAGGTGCCGGGAGCCCCGGGCCTGTCATGGTGGCCATCTACAGCCGGCCTGAGGCAGTCA
CAGACGGATTTGCAGCTGAGCCTGTCTATCTGGTGTGGGAAGAAGATGGGGAGTTACTTGTCAGTCCCGGCTTACTTCACCTCCAGAGAC
CTGTTTCGGTGTTCAGAATGCCAGGATTCCCTCACCAACTGGTACTATGAGAAGGATGGGAAGCTCTACTGCCCCAAGGACTACTGGGGG
AAGTTTGGGGAGTTCTGTCATGGGTGCTCCCTGCTGATGACAGGGCCTTTTATGGTAAATGAGCTGGATGGTATCCCGTTGATCCTGGAC
AACTGCAACATCAGTGACAGTAACCCCTTTCTGACCCAGTGGGTGATATATGCCATCCGAAACCTTACCGAAGACAACAGCCAAAACCAA
GATTTGATTGCAAAGATGGAGGAACAGGGGCTGGCAGATGCATCCCTACTTAAAAAAGTGGGTTTTGAAGTTGAAAAGAAAGGCGAAAAG
CTGATCCTGAAATCTACTAGAGACACCCCTAAGCCATGAATGAACTACATCCAAATACCTGAATTTTTGGAATCTGTTTCATGGATTTTT
CATCTTCTACCGTATGTGAAATTGCAAGTGTTTGAAGATTTATAAGTACAAATTTGGGAACATACAAATCTTTTAGGTAGTAGAGTTTAA
CGTGTATAAGCTAAAAGTGAAAGTAACTGAGTGTTCTCTTGTTTCTTTGCATTAATGTAACTGTGTGGTTTGCCTTTGTCCCCCTGGATA
GAACGTGCATTTAAAGAATATATTGTACTTACTGTGACAGCAGATAATAAACCAGTCTCTTGGAGGGCACAACCCTTATTTGACAAAACT
TGGATGTTGGCTTGACTGTGTTTGTCCCTTCAGATGGCAAGTCAGCATCATTCTTTATATTCCTCTTCTCATTGGGTTTTCTGAACTCTG
GCAGGCGGTTGAAGTAGTTTCTCACTGTGATTAATTCTAGCAATCTCTTTTCACCCCTCTGCCTTTCCAAAACATTGACAAGACTCATTT
CCAGTTAATTAATTCGAGAACCCTCCCTCTTCATTTTGGGTACTGGGCTGTCTTGTCACTGAGCCCTATCCCTTTGGAATGTGGCAGGGA
GTGAGGTTGGTGAGAGAACATGTGGGCACTTAACTCTTCATGTTCCAGTTCATCCCAGAAGTAGACATCCCAGGACCCATTCTGTGTCAA
GGTGAATGCCTGTGTCCTCCCCAGCTTCATGCCTCTGTCATGGGGGAAGGAATAGCTTATGTTCTGCTCTGGTGCAGTGCCGTAGATTAA
AGGTACATTTCTATCTTCTTTGATTTAAAAAGCACCAGTCTCATAAAGGTGCCACTCAGTTTTAGCCATGTCTTCACTGAAATTGCAAAA
GTACTTTTAGGGAGCAGGAGTTTATTTGACATCTAGTTATCTGTCTGTCTGTTCATCTATCTATCTGTCTGCTGTATGAGAGGTAGGACT
GGATTAAATGACCACTGAACTCACTGAATCCAGATCATTCATATCATCAACAAAAGCTCTAGGGGGAGGTCACGTTGTGAATGCTTAAAA
CATATTATTTTCTTCAACAACCATATCGCTAAACTAATATATCCAGAGATTTTGCACAATTCGTGTTGAACCTTCCAAAACAAAAATAAA
GACCTGTCCAAAAGTTTTGACAAAAATACTGATTGCTCCCAAATAAAGTGCTTCTAAGCTTTGTGTAGACATAGTTTAACTGATTTGTAA
AAATAGCTTAAGCATGTTGAGAATGAAGTAAAAGTTTTCCCATGTGCTGTCTAATGTACTCTGTGTAACTCTGAAGACACATCAGCTTCT
AGGATTGCAGCAATCTATGAATAACATTTTTTCTCTCATTTATGACTTTCCATCAGTAAAGAAGCCATTGCAGAATTTAAAATTACACAA
AGGAGTCATTCTCTCCTGGGACATAAAGAGTTAAAGCTCTGTCCTCTAAATAGAAGCCTGGCCAAAGGGAGAAAACAGTGGGAGTCCCTT
TTCCCTTTTAACAAGTTTGCAATAGACACTTCTTTTTTTCCTGTCTCAATGGATGTGTGCACACCAGTGGAATCGCACAAACTTGTCGGT

>44719_44719_4_LIMK2-ATXN10_LIMK2_chr22_31654412_ENST00000333611_ATXN10_chr22_46202839_ENST00000381061_length(amino acids)=205AA_BP=121
MESSGSRSCSGGRGELRAACLQPEVPGAPGLSWWPSTAGLRQSQTDLQLSLSIWCGKKMGSYLSVPAYFTSRDLFRCSECQDSLTNWYYE
KDGKLYCPKDYWGKFGEFCHGCSLLMTGPFMVNELDGIPLILDNCNISDSNPFLTQWVIYAIRNLTEDNSQNQDLIAKMEEQGLADASLL

--------------------------------------------------------------
>44719_44719_5_LIMK2-ATXN10_LIMK2_chr22_31654412_ENST00000340552_ATXN10_chr22_46202839_ENST00000252934_length(transcript)=2310nt_BP=419nt
GGGAGGAGCCATCCCAGCCATGAGCCCCTGTGGGAATCTGCTGGGGGCCAAGTGGCCTGGAGTCCTCAGGCTCCCGCAGCTGCTCCGGAG
GGAGAGGTGAGCTCAGGGCAGCCTGCCTGCAGCCAGAGGTGCCGGGAGCCCCGGGCCTGTCATGGTGGCCATCTACAGCCGGCCTGAGGC
AGTCACAGACGGATTTGCAGCTGAGCCTGTCTATCTGGTGTGGGAAGAAGATGGGGAGTTACTTGTCAGTCCCGGCTTACTTCACCTCCA
GAGACCTGTTTCGGTGTTCAGAATGCCAGGATTCCCTCACCAACTGGTACTATGAGAAGGATGGGAAGCTCTACTGCCCCAAGGACTACT
GGGGGAAGTTTGGGGAGTTCTGTCATGGGTGCTCCCTGCTGATGACAGGGCCTTTTATGGTAAATGAGCTGGATGGTATCCCGTTGATCC
TGGACAACTGCAACATCAGTGACAGTAACCCCTTTCTGACCCAGTGGGTGATATATGCCATCCGAAACCTTACCGAAGACAACAGCCAAA
ACCAAGATTTGATTGCAAAGATGGAGGAACAGGGGCTGGCAGATGCATCCCTACTTAAAAAAGTGGGTTTTGAAGTTGAAAAGAAAGGCG
AAAAGCTGATCCTGAAATCTACTAGAGACACCCCTAAGCCATGAATGAACTACATCCAAATACCTGAATTTTTGGAATCTGTTTCATGGA
TTTTTCATCTTCTACCGTATGTGAAATTGCAAGTGTTTGAAGATTTATAAGTACAAATTTGGGAACATACAAATCTTTTAGGTAGTAGAG
TTTAACGTGTATAAGCTAAAAGTGAAAGTAACTGAGTGTTCTCTTGTTTCTTTGCATTAATGTAACTGTGTGGTTTGCCTTTGTCCCCCT
GGATAGAACGTGCATTTAAAGAATATATTGTACTTACTGTGACAGCAGATAATAAACCAGTCTCTTGGAGGGCACAACCCTTATTTGACA
AAACTTGGATGTTGGCTTGACTGTGTTTGTCCCTTCAGATGGCAAGTCAGCATCATTCTTTATATTCCTCTTCTCATTGGGTTTTCTGAA
CTCTGGCAGGCGGTTGAAGTAGTTTCTCACTGTGATTAATTCTAGCAATCTCTTTTCACCCCTCTGCCTTTCCAAAACATTGACAAGACT
CATTTCCAGTTAATTAATTCGAGAACCCTCCCTCTTCATTTTGGGTACTGGGCTGTCTTGTCACTGAGCCCTATCCCTTTGGAATGTGGC
AGGGAGTGAGGTTGGTGAGAGAACATGTGGGCACTTAACTCTTCATGTTCCAGTTCATCCCAGAAGTAGACATCCCAGGACCCATTCTGT
GTCAAGGTGAATGCCTGTGTCCTCCCCAGCTTCATGCCTCTGTCATGGGGGAAGGAATAGCTTATGTTCTGCTCTGGTGCAGTGCCGTAG
ATTAAAGGTACATTTCTATCTTCTTTGATTTAAAAAGCACCAGTCTCATAAAGGTGCCACTCAGTTTTAGCCATGTCTTCACTGAAATTG
CAAAAGTACTTTTAGGGAGCAGGAGTTTATTTGACATCTAGTTATCTGTCTGTCTGTTCATCTATCTATCTGTCTGCTGTATGAGAGGTA
GGACTGGATTAAATGACCACTGAACTCACTGAATCCAGATCATTCATATCATCAACAAAAGCTCTAGGGGGAGGTCACGTTGTGAATGCT
TAAAACATATTATTTTCTTCAACAACCATATCGCTAAACTAATATATCCAGAGATTTTGCACAATTCGTGTTGAACCTTCCAAAACAAAA
ATAAAGACCTGTCCAAAAGTTTTGACAAAAATACTGATTGCTCCCAAATAAAGTGCTTCTAAGCTTTGTGTAGACATAGTTTAACTGATT
TGTAAAAATAGCTTAAGCATGTTGAGAATGAAGTAAAAGTTTTCCCATGTGCTGTCTAATGTACTCTGTGTAACTCTGAAGACACATCAG
CTTCTAGGATTGCAGCAATCTATGAATAACATTTTTTCTCTCATTTATGACTTTCCATCAGTAAAGAAGCCATTGCAGAATTTAAAATTA
CACAAAGGAGTCATTCTCTCCTGGGACATAAAGAGTTAAAGCTCTGTCCTCTAAATAGAAGCCTGGCCAAAGGGAGAAAACAGTGGGAGT
CCCTTTTCCCTTTTAACAAGTTTGCAATAGACACTTCTTTTTTTCCTGTCTCAATGGATGTGTGCACACCAGTGGAATCGCACAAACTTG

>44719_44719_5_LIMK2-ATXN10_LIMK2_chr22_31654412_ENST00000340552_ATXN10_chr22_46202839_ENST00000252934_length(amino acids)=205AA_BP=121
MESSGSRSCSGGRGELRAACLQPEVPGAPGLSWWPSTAGLRQSQTDLQLSLSIWCGKKMGSYLSVPAYFTSRDLFRCSECQDSLTNWYYE
KDGKLYCPKDYWGKFGEFCHGCSLLMTGPFMVNELDGIPLILDNCNISDSNPFLTQWVIYAIRNLTEDNSQNQDLIAKMEEQGLADASLL

--------------------------------------------------------------
>44719_44719_6_LIMK2-ATXN10_LIMK2_chr22_31654412_ENST00000340552_ATXN10_chr22_46202839_ENST00000381061_length(transcript)=2307nt_BP=419nt
GGGAGGAGCCATCCCAGCCATGAGCCCCTGTGGGAATCTGCTGGGGGCCAAGTGGCCTGGAGTCCTCAGGCTCCCGCAGCTGCTCCGGAG
GGAGAGGTGAGCTCAGGGCAGCCTGCCTGCAGCCAGAGGTGCCGGGAGCCCCGGGCCTGTCATGGTGGCCATCTACAGCCGGCCTGAGGC
AGTCACAGACGGATTTGCAGCTGAGCCTGTCTATCTGGTGTGGGAAGAAGATGGGGAGTTACTTGTCAGTCCCGGCTTACTTCACCTCCA
GAGACCTGTTTCGGTGTTCAGAATGCCAGGATTCCCTCACCAACTGGTACTATGAGAAGGATGGGAAGCTCTACTGCCCCAAGGACTACT
GGGGGAAGTTTGGGGAGTTCTGTCATGGGTGCTCCCTGCTGATGACAGGGCCTTTTATGGTAAATGAGCTGGATGGTATCCCGTTGATCC
TGGACAACTGCAACATCAGTGACAGTAACCCCTTTCTGACCCAGTGGGTGATATATGCCATCCGAAACCTTACCGAAGACAACAGCCAAA
ACCAAGATTTGATTGCAAAGATGGAGGAACAGGGGCTGGCAGATGCATCCCTACTTAAAAAAGTGGGTTTTGAAGTTGAAAAGAAAGGCG
AAAAGCTGATCCTGAAATCTACTAGAGACACCCCTAAGCCATGAATGAACTACATCCAAATACCTGAATTTTTGGAATCTGTTTCATGGA
TTTTTCATCTTCTACCGTATGTGAAATTGCAAGTGTTTGAAGATTTATAAGTACAAATTTGGGAACATACAAATCTTTTAGGTAGTAGAG
TTTAACGTGTATAAGCTAAAAGTGAAAGTAACTGAGTGTTCTCTTGTTTCTTTGCATTAATGTAACTGTGTGGTTTGCCTTTGTCCCCCT
GGATAGAACGTGCATTTAAAGAATATATTGTACTTACTGTGACAGCAGATAATAAACCAGTCTCTTGGAGGGCACAACCCTTATTTGACA
AAACTTGGATGTTGGCTTGACTGTGTTTGTCCCTTCAGATGGCAAGTCAGCATCATTCTTTATATTCCTCTTCTCATTGGGTTTTCTGAA
CTCTGGCAGGCGGTTGAAGTAGTTTCTCACTGTGATTAATTCTAGCAATCTCTTTTCACCCCTCTGCCTTTCCAAAACATTGACAAGACT
CATTTCCAGTTAATTAATTCGAGAACCCTCCCTCTTCATTTTGGGTACTGGGCTGTCTTGTCACTGAGCCCTATCCCTTTGGAATGTGGC
AGGGAGTGAGGTTGGTGAGAGAACATGTGGGCACTTAACTCTTCATGTTCCAGTTCATCCCAGAAGTAGACATCCCAGGACCCATTCTGT
GTCAAGGTGAATGCCTGTGTCCTCCCCAGCTTCATGCCTCTGTCATGGGGGAAGGAATAGCTTATGTTCTGCTCTGGTGCAGTGCCGTAG
ATTAAAGGTACATTTCTATCTTCTTTGATTTAAAAAGCACCAGTCTCATAAAGGTGCCACTCAGTTTTAGCCATGTCTTCACTGAAATTG
CAAAAGTACTTTTAGGGAGCAGGAGTTTATTTGACATCTAGTTATCTGTCTGTCTGTTCATCTATCTATCTGTCTGCTGTATGAGAGGTA
GGACTGGATTAAATGACCACTGAACTCACTGAATCCAGATCATTCATATCATCAACAAAAGCTCTAGGGGGAGGTCACGTTGTGAATGCT
TAAAACATATTATTTTCTTCAACAACCATATCGCTAAACTAATATATCCAGAGATTTTGCACAATTCGTGTTGAACCTTCCAAAACAAAA
ATAAAGACCTGTCCAAAAGTTTTGACAAAAATACTGATTGCTCCCAAATAAAGTGCTTCTAAGCTTTGTGTAGACATAGTTTAACTGATT
TGTAAAAATAGCTTAAGCATGTTGAGAATGAAGTAAAAGTTTTCCCATGTGCTGTCTAATGTACTCTGTGTAACTCTGAAGACACATCAG
CTTCTAGGATTGCAGCAATCTATGAATAACATTTTTTCTCTCATTTATGACTTTCCATCAGTAAAGAAGCCATTGCAGAATTTAAAATTA
CACAAAGGAGTCATTCTCTCCTGGGACATAAAGAGTTAAAGCTCTGTCCTCTAAATAGAAGCCTGGCCAAAGGGAGAAAACAGTGGGAGT
CCCTTTTCCCTTTTAACAAGTTTGCAATAGACACTTCTTTTTTTCCTGTCTCAATGGATGTGTGCACACCAGTGGAATCGCACAAACTTG

>44719_44719_6_LIMK2-ATXN10_LIMK2_chr22_31654412_ENST00000340552_ATXN10_chr22_46202839_ENST00000381061_length(amino acids)=205AA_BP=121
MESSGSRSCSGGRGELRAACLQPEVPGAPGLSWWPSTAGLRQSQTDLQLSLSIWCGKKMGSYLSVPAYFTSRDLFRCSECQDSLTNWYYE
KDGKLYCPKDYWGKFGEFCHGCSLLMTGPFMVNELDGIPLILDNCNISDSNPFLTQWVIYAIRNLTEDNSQNQDLIAKMEEQGLADASLL

--------------------------------------------------------------
>44719_44719_7_LIMK2-ATXN10_LIMK2_chr22_31654412_ENST00000406516_ATXN10_chr22_46202839_ENST00000252934_length(transcript)=2178nt_BP=287nt
ATCCCGTTCGCGCCTGGGGCTGTGGTCTTCCCGCGCCTGAGGCGGCGGCGGCAGGAGCTGAGGGGAGTTGTAGGGAACTGAGGGGAGCTG
CTGTGTCCCCCGCCTCCTCCTCCCCATTTCCGCGCTCCCGGGACCATGTCCGCGCTGGCGGGTGTTCAGAATGCCAGGATTCCCTCACCA
ACTGGTACTATGAGAAGGATGGGAAGCTCTACTGCCCCAAGGACTACTGGGGGAAGTTTGGGGAGTTCTGTCATGGGTGCTCCCTGCTGA
TGACAGGGCCTTTTATGGTAAATGAGCTGGATGGTATCCCGTTGATCCTGGACAACTGCAACATCAGTGACAGTAACCCCTTTCTGACCC
AGTGGGTGATATATGCCATCCGAAACCTTACCGAAGACAACAGCCAAAACCAAGATTTGATTGCAAAGATGGAGGAACAGGGGCTGGCAG
ATGCATCCCTACTTAAAAAAGTGGGTTTTGAAGTTGAAAAGAAAGGCGAAAAGCTGATCCTGAAATCTACTAGAGACACCCCTAAGCCAT
GAATGAACTACATCCAAATACCTGAATTTTTGGAATCTGTTTCATGGATTTTTCATCTTCTACCGTATGTGAAATTGCAAGTGTTTGAAG
ATTTATAAGTACAAATTTGGGAACATACAAATCTTTTAGGTAGTAGAGTTTAACGTGTATAAGCTAAAAGTGAAAGTAACTGAGTGTTCT
CTTGTTTCTTTGCATTAATGTAACTGTGTGGTTTGCCTTTGTCCCCCTGGATAGAACGTGCATTTAAAGAATATATTGTACTTACTGTGA
CAGCAGATAATAAACCAGTCTCTTGGAGGGCACAACCCTTATTTGACAAAACTTGGATGTTGGCTTGACTGTGTTTGTCCCTTCAGATGG
CAAGTCAGCATCATTCTTTATATTCCTCTTCTCATTGGGTTTTCTGAACTCTGGCAGGCGGTTGAAGTAGTTTCTCACTGTGATTAATTC
TAGCAATCTCTTTTCACCCCTCTGCCTTTCCAAAACATTGACAAGACTCATTTCCAGTTAATTAATTCGAGAACCCTCCCTCTTCATTTT
GGGTACTGGGCTGTCTTGTCACTGAGCCCTATCCCTTTGGAATGTGGCAGGGAGTGAGGTTGGTGAGAGAACATGTGGGCACTTAACTCT
TCATGTTCCAGTTCATCCCAGAAGTAGACATCCCAGGACCCATTCTGTGTCAAGGTGAATGCCTGTGTCCTCCCCAGCTTCATGCCTCTG
TCATGGGGGAAGGAATAGCTTATGTTCTGCTCTGGTGCAGTGCCGTAGATTAAAGGTACATTTCTATCTTCTTTGATTTAAAAAGCACCA
GTCTCATAAAGGTGCCACTCAGTTTTAGCCATGTCTTCACTGAAATTGCAAAAGTACTTTTAGGGAGCAGGAGTTTATTTGACATCTAGT
TATCTGTCTGTCTGTTCATCTATCTATCTGTCTGCTGTATGAGAGGTAGGACTGGATTAAATGACCACTGAACTCACTGAATCCAGATCA
TTCATATCATCAACAAAAGCTCTAGGGGGAGGTCACGTTGTGAATGCTTAAAACATATTATTTTCTTCAACAACCATATCGCTAAACTAA
TATATCCAGAGATTTTGCACAATTCGTGTTGAACCTTCCAAAACAAAAATAAAGACCTGTCCAAAAGTTTTGACAAAAATACTGATTGCT
CCCAAATAAAGTGCTTCTAAGCTTTGTGTAGACATAGTTTAACTGATTTGTAAAAATAGCTTAAGCATGTTGAGAATGAAGTAAAAGTTT
TCCCATGTGCTGTCTAATGTACTCTGTGTAACTCTGAAGACACATCAGCTTCTAGGATTGCAGCAATCTATGAATAACATTTTTTCTCTC
ATTTATGACTTTCCATCAGTAAAGAAGCCATTGCAGAATTTAAAATTACACAAAGGAGTCATTCTCTCCTGGGACATAAAGAGTTAAAGC
TCTGTCCTCTAAATAGAAGCCTGGCCAAAGGGAGAAAACAGTGGGAGTCCCTTTTCCCTTTTAACAAGTTTGCAATAGACACTTCTTTTT
TTCCTGTCTCAATGGATGTGTGCACACCAGTGGAATCGCACAAACTTGTCGGTATGAGCTATATAATAACAAACACAAATAAATAAAAGG

>44719_44719_7_LIMK2-ATXN10_LIMK2_chr22_31654412_ENST00000406516_ATXN10_chr22_46202839_ENST00000252934_length(amino acids)=154AA_BP=70
MRGAAVSPASSSPFPRSRDHVRAGGCSECQDSLTNWYYEKDGKLYCPKDYWGKFGEFCHGCSLLMTGPFMVNELDGIPLILDNCNISDSN

--------------------------------------------------------------
>44719_44719_8_LIMK2-ATXN10_LIMK2_chr22_31654412_ENST00000406516_ATXN10_chr22_46202839_ENST00000381061_length(transcript)=2175nt_BP=287nt
ATCCCGTTCGCGCCTGGGGCTGTGGTCTTCCCGCGCCTGAGGCGGCGGCGGCAGGAGCTGAGGGGAGTTGTAGGGAACTGAGGGGAGCTG
CTGTGTCCCCCGCCTCCTCCTCCCCATTTCCGCGCTCCCGGGACCATGTCCGCGCTGGCGGGTGTTCAGAATGCCAGGATTCCCTCACCA
ACTGGTACTATGAGAAGGATGGGAAGCTCTACTGCCCCAAGGACTACTGGGGGAAGTTTGGGGAGTTCTGTCATGGGTGCTCCCTGCTGA
TGACAGGGCCTTTTATGGTAAATGAGCTGGATGGTATCCCGTTGATCCTGGACAACTGCAACATCAGTGACAGTAACCCCTTTCTGACCC
AGTGGGTGATATATGCCATCCGAAACCTTACCGAAGACAACAGCCAAAACCAAGATTTGATTGCAAAGATGGAGGAACAGGGGCTGGCAG
ATGCATCCCTACTTAAAAAAGTGGGTTTTGAAGTTGAAAAGAAAGGCGAAAAGCTGATCCTGAAATCTACTAGAGACACCCCTAAGCCAT
GAATGAACTACATCCAAATACCTGAATTTTTGGAATCTGTTTCATGGATTTTTCATCTTCTACCGTATGTGAAATTGCAAGTGTTTGAAG
ATTTATAAGTACAAATTTGGGAACATACAAATCTTTTAGGTAGTAGAGTTTAACGTGTATAAGCTAAAAGTGAAAGTAACTGAGTGTTCT
CTTGTTTCTTTGCATTAATGTAACTGTGTGGTTTGCCTTTGTCCCCCTGGATAGAACGTGCATTTAAAGAATATATTGTACTTACTGTGA
CAGCAGATAATAAACCAGTCTCTTGGAGGGCACAACCCTTATTTGACAAAACTTGGATGTTGGCTTGACTGTGTTTGTCCCTTCAGATGG
CAAGTCAGCATCATTCTTTATATTCCTCTTCTCATTGGGTTTTCTGAACTCTGGCAGGCGGTTGAAGTAGTTTCTCACTGTGATTAATTC
TAGCAATCTCTTTTCACCCCTCTGCCTTTCCAAAACATTGACAAGACTCATTTCCAGTTAATTAATTCGAGAACCCTCCCTCTTCATTTT
GGGTACTGGGCTGTCTTGTCACTGAGCCCTATCCCTTTGGAATGTGGCAGGGAGTGAGGTTGGTGAGAGAACATGTGGGCACTTAACTCT
TCATGTTCCAGTTCATCCCAGAAGTAGACATCCCAGGACCCATTCTGTGTCAAGGTGAATGCCTGTGTCCTCCCCAGCTTCATGCCTCTG
TCATGGGGGAAGGAATAGCTTATGTTCTGCTCTGGTGCAGTGCCGTAGATTAAAGGTACATTTCTATCTTCTTTGATTTAAAAAGCACCA
GTCTCATAAAGGTGCCACTCAGTTTTAGCCATGTCTTCACTGAAATTGCAAAAGTACTTTTAGGGAGCAGGAGTTTATTTGACATCTAGT
TATCTGTCTGTCTGTTCATCTATCTATCTGTCTGCTGTATGAGAGGTAGGACTGGATTAAATGACCACTGAACTCACTGAATCCAGATCA
TTCATATCATCAACAAAAGCTCTAGGGGGAGGTCACGTTGTGAATGCTTAAAACATATTATTTTCTTCAACAACCATATCGCTAAACTAA
TATATCCAGAGATTTTGCACAATTCGTGTTGAACCTTCCAAAACAAAAATAAAGACCTGTCCAAAAGTTTTGACAAAAATACTGATTGCT
CCCAAATAAAGTGCTTCTAAGCTTTGTGTAGACATAGTTTAACTGATTTGTAAAAATAGCTTAAGCATGTTGAGAATGAAGTAAAAGTTT
TCCCATGTGCTGTCTAATGTACTCTGTGTAACTCTGAAGACACATCAGCTTCTAGGATTGCAGCAATCTATGAATAACATTTTTTCTCTC
ATTTATGACTTTCCATCAGTAAAGAAGCCATTGCAGAATTTAAAATTACACAAAGGAGTCATTCTCTCCTGGGACATAAAGAGTTAAAGC
TCTGTCCTCTAAATAGAAGCCTGGCCAAAGGGAGAAAACAGTGGGAGTCCCTTTTCCCTTTTAACAAGTTTGCAATAGACACTTCTTTTT
TTCCTGTCTCAATGGATGTGTGCACACCAGTGGAATCGCACAAACTTGTCGGTATGAGCTATATAATAACAAACACAAATAAATAAAAGG

>44719_44719_8_LIMK2-ATXN10_LIMK2_chr22_31654412_ENST00000406516_ATXN10_chr22_46202839_ENST00000381061_length(amino acids)=154AA_BP=70
MRGAAVSPASSSPFPRSRDHVRAGGCSECQDSLTNWYYEKDGKLYCPKDYWGKFGEFCHGCSLLMTGPFMVNELDGIPLILDNCNISDSN

--------------------------------------------------------------

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Fusion Gene PPI Analysis for LIMK2-ATXN10


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for LIMK2-ATXN10


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for LIMK2-ATXN10


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource