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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:LIN9-EZR (FusionGDB2 ID:44787)

Fusion Gene Summary for LIN9-EZR

Fusion gene summary

Fusion gene information	Fusion gene name: LIN9-EZR
	Fusion gene ID: 44787
		Hgene	Tgene
	Gene symbol	LIN9	EZR
	Gene ID	286826	7430
	Gene name	lin-9 DREAM MuvB core complex component	ezrin
	Synonyms	BARA\|BARPsv\|Lin-9\|TGS\|TGS1\|TGS2	CVIL\|CVL\|HEL-S-105\|VIL2
	Cytomap	1q42.12	6q25.3
	Type of gene	protein-coding	protein-coding
	Description	protein lin-9 homologTUDOR gene similar proteinbeta subunit-associated regulator of apoptosislin-9 homologpRB-associated proteinrb related pathway actortype I interferon receptor beta chain-associated protein	ezrincytovillin 2epididymis secretory protein Li 105p81villin 2 (ezrin)
	Modification date	20200313	20200322
	UniProtAcc	Q5TKA1	P15311
	Ensembl transtripts involved in fusion gene	ENST00000328205, ENST00000366801, ENST00000481685,	ENST00000476189, ENST00000337147, ENST00000367075, ENST00000392177,
Fusion gene scores	* DoF score	6 X 6 X 4=144	25 X 24 X 6=3600
	# samples	6	27
	** MAII score	log2(6/144*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(27/3600*10)=-3.73696559416621 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: LIN9 [Title/Abstract] AND EZR [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	LIN9(226485419)-EZR(159210403), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	EZR	GO:0048015	phosphatidylinositol-mediated signaling	25591774
Tgene	EZR	GO:0051017	actin filament bundle assembly	10793131

Fusion gene breakpoints across LIN9 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across EZR (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-D7-A4YV	LIN9	chr1	226485419	-	EZR	chr6	159210403	-

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Fusion Gene ORF analysis for LIN9-EZR

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000328205	ENST00000476189	LIN9	chr1	226485419	-	EZR	chr6	159210403	-
5CDS-5UTR	ENST00000366801	ENST00000476189	LIN9	chr1	226485419	-	EZR	chr6	159210403	-
5CDS-5UTR	ENST00000481685	ENST00000476189	LIN9	chr1	226485419	-	EZR	chr6	159210403	-
In-frame	ENST00000328205	ENST00000337147	LIN9	chr1	226485419	-	EZR	chr6	159210403	-
In-frame	ENST00000328205	ENST00000367075	LIN9	chr1	226485419	-	EZR	chr6	159210403	-
In-frame	ENST00000328205	ENST00000392177	LIN9	chr1	226485419	-	EZR	chr6	159210403	-
In-frame	ENST00000366801	ENST00000337147	LIN9	chr1	226485419	-	EZR	chr6	159210403	-
In-frame	ENST00000366801	ENST00000367075	LIN9	chr1	226485419	-	EZR	chr6	159210403	-
In-frame	ENST00000366801	ENST00000392177	LIN9	chr1	226485419	-	EZR	chr6	159210403	-
In-frame	ENST00000481685	ENST00000337147	LIN9	chr1	226485419	-	EZR	chr6	159210403	-
In-frame	ENST00000481685	ENST00000367075	LIN9	chr1	226485419	-	EZR	chr6	159210403	-
In-frame	ENST00000481685	ENST00000392177	LIN9	chr1	226485419	-	EZR	chr6	159210403	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000328205	LIN9	chr1	226485419	-	ENST00000337147	EZR	chr6	159210403	-	3675	753	144	2501	785
ENST00000328205	LIN9	chr1	226485419	-	ENST00000367075	EZR	chr6	159210403	-	3668	753	144	2501	785
ENST00000328205	LIN9	chr1	226485419	-	ENST00000392177	EZR	chr6	159210403	-	2424	753	144	2405	753
ENST00000366801	LIN9	chr1	226485419	-	ENST00000337147	EZR	chr6	159210403	-	3439	517	310	2265	651
ENST00000366801	LIN9	chr1	226485419	-	ENST00000367075	EZR	chr6	159210403	-	3432	517	310	2265	651
ENST00000366801	LIN9	chr1	226485419	-	ENST00000392177	EZR	chr6	159210403	-	2188	517	310	2169	619
ENST00000481685	LIN9	chr1	226485419	-	ENST00000337147	EZR	chr6	159210403	-	3196	274	67	2022	651
ENST00000481685	LIN9	chr1	226485419	-	ENST00000367075	EZR	chr6	159210403	-	3189	274	67	2022	651
ENST00000481685	LIN9	chr1	226485419	-	ENST00000392177	EZR	chr6	159210403	-	1945	274	67	1926	619

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000328205	ENST00000337147	LIN9	chr1	226485419	-	EZR	chr6	159210403	-	0.004448726	0.99555135
ENST00000328205	ENST00000367075	LIN9	chr1	226485419	-	EZR	chr6	159210403	-	0.004319898	0.9956801
ENST00000328205	ENST00000392177	LIN9	chr1	226485419	-	EZR	chr6	159210403	-	0.021508306	0.97849166
ENST00000366801	ENST00000337147	LIN9	chr1	226485419	-	EZR	chr6	159210403	-	0.003154988	0.996845
ENST00000366801	ENST00000367075	LIN9	chr1	226485419	-	EZR	chr6	159210403	-	0.003070478	0.9969296
ENST00000366801	ENST00000392177	LIN9	chr1	226485419	-	EZR	chr6	159210403	-	0.012785963	0.98721397
ENST00000481685	ENST00000337147	LIN9	chr1	226485419	-	EZR	chr6	159210403	-	0.002680471	0.9973195
ENST00000481685	ENST00000367075	LIN9	chr1	226485419	-	EZR	chr6	159210403	-	0.002589349	0.9974107
ENST00000481685	ENST00000392177	LIN9	chr1	226485419	-	EZR	chr6	159210403	-	0.014614806	0.98538524

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Fusion Genomic Features for LIN9-EZR

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for LIN9-EZR

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:226485419/chr6:159210403)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
LIN9 Q5TKA1	EZR P15311
FUNCTION: Acts as a tumor suppressor. Inhibits DNA synthesis. Its ability to inhibit oncogenic transformation is mediated through its association with RB1. Plays a role in the expression of genes required for the G1/S transition. {ECO:0000269\|PubMed:15538385, ECO:0000269\|PubMed:16730350}.	FUNCTION: Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis. {ECO:0000269\|PubMed:17881735, ECO:0000269\|PubMed:18270268, ECO:0000269\|PubMed:19111582}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

EZR

chr1:226485419

chr6:159210403

ENST00000337147

2_295

587.0

Domain

FERM

Tgene

EZR

chr1:226485419

chr6:159210403

ENST00000367075

2_295

587.0

Domain

FERM

Tgene

EZR

chr1:226485419

chr6:159210403

ENST00000337147

115_120

587.0

Motif

[IL]-x-C-x-x-[DE] motif

Tgene

EZR

chr1:226485419

chr6:159210403

ENST00000367075

115_120

587.0

Motif

[IL]-x-C-x-x-[DE] motif

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

LIN9

chr1:226485419

chr6:159210403

ENST00000328205

354_413

559.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

LIN9

chr1:226485419

chr6:159210403

ENST00000366801

354_413

508.0

Coiled coil

Ontology_term=ECO:0000255

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Fusion Gene Sequence for LIN9-EZR

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>44787_44787_1_LIN9-EZR_LIN9_chr1_226485419_ENST00000328205_EZR_chr6_159210403_ENST00000337147_length(transcript)=3675nt_BP=753nt
GCTGGGACCGAGTCCCGGACGTCGCGACGCGCAGGGGGCTGCTGCGGCCGGCGGTCTCGGGAAAAGTGAGGGGACGGAGGCGCCCAAGCA
ACGTGGGTTTCGGGAACTGTGAGTATTTCACTTTGCGTAGAGCCCCCTCGGGCAATGCGACCCAGAACCGAGGGCTTCTTTCCCCCCGCC
GGGGCCTCCCTCCCGTTCTCCACTCGGAACAAACAGCCTGCAGTTCCCGCAGCTGCAGCGCGGGCCGCGGAACATGCGCCGGGAGCGGGG
CCCGGGCGGGACTCCGGAGCTGGTACTGCTCCCCCCGCGCTCCGGCGCCGGGCCTCGCCGTGCGGCCTCCTTCCTCCCTTCCTCCCGCCC
GGCTCGGCCGGAGGCGGCGGCGGAGGGGCGAGGCGCGGCCCCCCTTCGGCGGCACCTCCTCCCCGGGCAGGCGCGGGCGGAGCCGGGCCC
GCCTCAGCCAGCCGCGGCGGGAGCAGCGCAGCGCGGCGCCGCGGGCAGCGAGCTCCGCATTCGAACCTCCCTCGCAAAGACAGTCTCCGC
CCCACAATGCACCGCGGCGGGCAGCCTTTGAAAAAGCGGCGCGGCTCGTTCAAGATGGCGGAGCTCGACCAGTTGCCTGACGAGAGCTCT
TCAGCAAAAGCCCTTGTCAGTTTAAAAGAAGGAAGCTTATCTAACACGTGGAATGAAAAGTACAGTTCTTTACAGAAAACACCTGTTTGG
AAAGGCAGGAATACAAGCTCTGCTGTGGAAATGATCAATGTCCGAGTTACCACCATGGATGCAGAGCTGGAGTTTGCAATCCAGCCAAAT
ACAACTGGAAAACAGCTTTTTGATCAGGTGGTAAAGACTATCGGCCTCCGGGAAGTGTGGTACTTTGGCCTCCACTATGTGGATAATAAA
GGATTTCCTACCTGGCTGAAGCTGGATAAGAAGGTGTCTGCCCAGGAGGTCAGGAAGGAGAATCCCCTCCAGTTCAAGTTCCGGGCCAAG
TTCTACCCTGAAGATGTGGCTGAGGAGCTCATCCAGGACATCACCCAGAAACTTTTCTTCCTCCAAGTGAAGGAAGGAATCCTTAGCGAT
GAGATCTACTGCCCCCCTGAGACTGCCGTGCTCTTGGGGTCCTACGCTGTGCAGGCCAAGTTTGGGGACTACAACAAAGAAGTGCACAAG
TCTGGGTACCTCAGCTCTGAGCGGCTGATCCCTCAAAGAGTGATGGACCAGCACAAACTTACCAGGGACCAGTGGGAGGACCGGATCCAG
GTGTGGCATGCGGAACACCGTGGGATGCTCAAAGATAATGCTATGTTGGAATACCTGAAGATTGCTCAGGACCTGGAAATGTATGGAATC
AACTATTTCGAGATAAAAAACAAGAAAGGAACAGACCTTTGGCTTGGAGTTGATGCCCTTGGACTGAATATTTATGAGAAAGATGATAAG
TTAACCCCAAAGATTGGCTTTCCTTGGAGTGAAATCAGGAACATCTCTTTCAATGACAAAAAGTTTGTCATTAAACCCATCGACAAGAAG
GCACCTGACTTTGTGTTTTATGCCCCACGTCTGAGAATCAACAAGCGGATCCTGCAGCTCTGCATGGGCAACCATGAGTTGTATATGCGC
CGCAGGAAGCCTGACACCATCGAGGTGCAGCAGATGAAGGCCCAGGCCCGGGAGGAGAAGCATCAGAAGCAGCTGGAGCGGCAACAGCTG
GAAACAGAGAAGAAAAGGAGAGAAACCGTGGAGAGAGAGAAAGAGCAGATGATGCGCGAGAAGGAGGAGTTGATGCTGCGGCTGCAGGAC
TATGAGGAGAAGACAAAGAAGGCAGAGAGAGAGCTCTCGGAGCAGATTCAGAGGGCCCTGCAGCTGGAGGAGGAGAGGAAGCGGGCACAG
GAGGAGGCCGAGCGCCTAGAGGCTGACCGTATGGCTGCACTGCGGGCTAAGGAGGAGCTGGAGAGACAGGCGGTGGATCAGATAAAGAGC
CAGGAGCAGCTGGCTGCGGAGCTTGCAGAATACACTGCCAAGATTGCCCTCCTGGAAGAGGCGCGGAGGCGCAAGGAGGATGAAGTTGAA
GAGTGGCAGCACAGGGCCAAAGAAGCCCAGGATGACCTGGTGAAGACCAAGGAGGAGCTGCACCTGGTGATGACAGCACCCCCGCCCCCA
CCACCCCCCGTGTACGAGCCGGTGAGCTACCATGTCCAGGAGAGCTTGCAGGATGAGGGCGCAGAGCCCACGGGCTACAGCGCGGAGCTG
TCTAGTGAGGGCATCCGGGATGACCGCAATGAGGAGAAGCGCATCACTGAGGCAGAGAAGAACGAGCGTGTGCAGCGGCAGCTGCTGACG
CTGAGCAGCGAGCTGTCCCAGGCCCGAGATGAGAATAAGAGGACCCACAATGACATCATCCACAACGAGAACATGAGGCAAGGCCGGGAC
AAGTACAAGACGCTGCGGCAGATCCGGCAGGGCAACACCAAGCAGCGCATCGACGAGTTCGAGGCCCTGTAACAGCCAGGCCAGGACCAA
GGGCAGAGGGGTGCTCATAGCGGGCGCTGCCAGCCCCGCCACGCTTGTGTCTTTAGTGCTCCAAGTCTAGGAACTCCCTCAGATCCCAGT
TCCTTTAGAAAGCAGTTACCCAACAGAAACATTCTGGGCTGGGAACCAGGGAGGCGCCCTGGTTTGTTTTCCCCAGTTGTAATAGTGCCA
AGCAGGCCTGATTCTCGCGATTATTCTCGAATCACCTCCTGTGTTGTGCTGGGAGCAGGACTGATTGAATTACGGAAAATGCCTGTAAAG
TCTGAGTAAGAAACTTCATGCTGGCCTGTGTGATACAAGAGTCAGCATCATTAAAGGAAACGTGGCAGGACTTCCATCTGTGCCATACTT
GTTCTGTATTCGAAATGAGCTCAAATTGATTTTTTAATTTCTATGAAGGATCCATCTTTGTATATTTACATGCTTAGAGGGGTGAAAATT
ATTTTGGAAATTGAGTCTGAAGCACTCTCGCACACACAGTGATTCCCTCCTCCCGTCACTCCACGCAGCTGGCAGAGAGCACAGTGATCA
CCAGCGTGAGTGGTGGAGGAGGACACTTGGATTTTTTTTTTTGTTTTTTTTTTTTTTGCTTAACAGTTTTAGAATACATTGTACTTATAC
ACCTTATTAATGATCAGCTATATACTATTTATATACAAGTGATAATACAGATTTGTAACATTAGTTTTAAAAAGGGAAAGTTTTGTTCTG
TATATTTTGTTACCTTTTACAGAATAAAAGAATTACATATGAAAAACCCTCTAAACCATGGCACTTGATGTGATGTGGCAGGAGGGCAGT
GGTGGAGCTGGACCTGCCTGCTGCAGTCACGTGTAAACAGGATTATTATTAGTGTTTTATGCATGTAATGGACTATGCACACTTTTAATT
TTGTCAGATTCACACATGCCACTATGAGCTTTCAGACTCCAGCTGTGAAGAGACTCTGTTTGCTTGTGTTTGTTTGTTTGCAGTCTCTCT
CTGCCATGGCCTTGGCAGGCTGCTGGAAGGCAGCTTGTGGAGGCCGTTGGTTCCGCCCACTCATTCCTTCTCGTGCACTGCTTTCTCCTT

>44787_44787_1_LIN9-EZR_LIN9_chr1_226485419_ENST00000328205_EZR_chr6_159210403_ENST00000337147_length(amino acids)=785AA_BP=203
MRPRTEGFFPPAGASLPFSTRNKQPAVPAAAARAAEHAPGAGPGRDSGAGTAPPALRRRASPCGLLPPFLPPGSAGGGGGGARRGPPSAA
PPPRAGAGGAGPASASRGGSSAARRRGQRAPHSNLPRKDSLRPTMHRGGQPLKKRRGSFKMAELDQLPDESSSAKALVSLKEGSLSNTWN
EKYSSLQKTPVWKGRNTSSAVEMINVRVTTMDAELEFAIQPNTTGKQLFDQVVKTIGLREVWYFGLHYVDNKGFPTWLKLDKKVSAQEVR
KENPLQFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYCPPETAVLLGSYAVQAKFGDYNKEVHKSGYLSSERLIPQRVMDQH
KLTRDQWEDRIQVWHAEHRGMLKDNAMLEYLKIAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGFPWSEIRNISFN
DKKFVIKPIDKKAPDFVFYAPRLRINKRILQLCMGNHELYMRRRKPDTIEVQQMKAQAREEKHQKQLERQQLETEKKRRETVEREKEQMM
REKEELMLRLQDYEEKTKKAERELSEQIQRALQLEEERKRAQEEAERLEADRMAALRAKEELERQAVDQIKSQEQLAAELAEYTAKIALL
EEARRRKEDEVEEWQHRAKEAQDDLVKTKEELHLVMTAPPPPPPPVYEPVSYHVQESLQDEGAEPTGYSAELSSEGIRDDRNEEKRITEA

--------------------------------------------------------------
>44787_44787_2_LIN9-EZR_LIN9_chr1_226485419_ENST00000328205_EZR_chr6_159210403_ENST00000367075_length(transcript)=3668nt_BP=753nt
GCTGGGACCGAGTCCCGGACGTCGCGACGCGCAGGGGGCTGCTGCGGCCGGCGGTCTCGGGAAAAGTGAGGGGACGGAGGCGCCCAAGCA
ACGTGGGTTTCGGGAACTGTGAGTATTTCACTTTGCGTAGAGCCCCCTCGGGCAATGCGACCCAGAACCGAGGGCTTCTTTCCCCCCGCC
GGGGCCTCCCTCCCGTTCTCCACTCGGAACAAACAGCCTGCAGTTCCCGCAGCTGCAGCGCGGGCCGCGGAACATGCGCCGGGAGCGGGG
CCCGGGCGGGACTCCGGAGCTGGTACTGCTCCCCCCGCGCTCCGGCGCCGGGCCTCGCCGTGCGGCCTCCTTCCTCCCTTCCTCCCGCCC
GGCTCGGCCGGAGGCGGCGGCGGAGGGGCGAGGCGCGGCCCCCCTTCGGCGGCACCTCCTCCCCGGGCAGGCGCGGGCGGAGCCGGGCCC
GCCTCAGCCAGCCGCGGCGGGAGCAGCGCAGCGCGGCGCCGCGGGCAGCGAGCTCCGCATTCGAACCTCCCTCGCAAAGACAGTCTCCGC
CCCACAATGCACCGCGGCGGGCAGCCTTTGAAAAAGCGGCGCGGCTCGTTCAAGATGGCGGAGCTCGACCAGTTGCCTGACGAGAGCTCT
TCAGCAAAAGCCCTTGTCAGTTTAAAAGAAGGAAGCTTATCTAACACGTGGAATGAAAAGTACAGTTCTTTACAGAAAACACCTGTTTGG
AAAGGCAGGAATACAAGCTCTGCTGTGGAAATGATCAATGTCCGAGTTACCACCATGGATGCAGAGCTGGAGTTTGCAATCCAGCCAAAT
ACAACTGGAAAACAGCTTTTTGATCAGGTGGTAAAGACTATCGGCCTCCGGGAAGTGTGGTACTTTGGCCTCCACTATGTGGATAATAAA
GGATTTCCTACCTGGCTGAAGCTGGATAAGAAGGTGTCTGCCCAGGAGGTCAGGAAGGAGAATCCCCTCCAGTTCAAGTTCCGGGCCAAG
TTCTACCCTGAAGATGTGGCTGAGGAGCTCATCCAGGACATCACCCAGAAACTTTTCTTCCTCCAAGTGAAGGAAGGAATCCTTAGCGAT
GAGATCTACTGCCCCCCTGAGACTGCCGTGCTCTTGGGGTCCTACGCTGTGCAGGCCAAGTTTGGGGACTACAACAAAGAAGTGCACAAG
TCTGGGTACCTCAGCTCTGAGCGGCTGATCCCTCAAAGAGTGATGGACCAGCACAAACTTACCAGGGACCAGTGGGAGGACCGGATCCAG
GTGTGGCATGCGGAACACCGTGGGATGCTCAAAGATAATGCTATGTTGGAATACCTGAAGATTGCTCAGGACCTGGAAATGTATGGAATC
AACTATTTCGAGATAAAAAACAAGAAAGGAACAGACCTTTGGCTTGGAGTTGATGCCCTTGGACTGAATATTTATGAGAAAGATGATAAG
TTAACCCCAAAGATTGGCTTTCCTTGGAGTGAAATCAGGAACATCTCTTTCAATGACAAAAAGTTTGTCATTAAACCCATCGACAAGAAG
GCACCTGACTTTGTGTTTTATGCCCCACGTCTGAGAATCAACAAGCGGATCCTGCAGCTCTGCATGGGCAACCATGAGTTGTATATGCGC
CGCAGGAAGCCTGACACCATCGAGGTGCAGCAGATGAAGGCCCAGGCCCGGGAGGAGAAGCATCAGAAGCAGCTGGAGCGGCAACAGCTG
GAAACAGAGAAGAAAAGGAGAGAAACCGTGGAGAGAGAGAAAGAGCAGATGATGCGCGAGAAGGAGGAGTTGATGCTGCGGCTGCAGGAC
TATGAGGAGAAGACAAAGAAGGCAGAGAGAGAGCTCTCGGAGCAGATTCAGAGGGCCCTGCAGCTGGAGGAGGAGAGGAAGCGGGCACAG
GAGGAGGCCGAGCGCCTAGAGGCTGACCGTATGGCTGCACTGCGGGCTAAGGAGGAGCTGGAGAGACAGGCGGTGGATCAGATAAAGAGC
CAGGAGCAGCTGGCTGCGGAGCTTGCAGAATACACTGCCAAGATTGCCCTCCTGGAAGAGGCGCGGAGGCGCAAGGAGGATGAAGTTGAA
GAGTGGCAGCACAGGGCCAAAGAAGCCCAGGATGACCTGGTGAAGACCAAGGAGGAGCTGCACCTGGTGATGACAGCACCCCCGCCCCCA
CCACCCCCCGTGTACGAGCCGGTGAGCTACCATGTCCAGGAGAGCTTGCAGGATGAGGGCGCAGAGCCCACGGGCTACAGCGCGGAGCTG
TCTAGTGAGGGCATCCGGGATGACCGCAATGAGGAGAAGCGCATCACTGAGGCAGAGAAGAACGAGCGTGTGCAGCGGCAGCTGCTGACG
CTGAGCAGCGAGCTGTCCCAGGCCCGAGATGAGAATAAGAGGACCCACAATGACATCATCCACAACGAGAACATGAGGCAAGGCCGGGAC
AAGTACAAGACGCTGCGGCAGATCCGGCAGGGCAACACCAAGCAGCGCATCGACGAGTTCGAGGCCCTGTAACAGCCAGGCCAGGACCAA
GGGCAGAGGGGTGCTCATAGCGGGCGCTGCCAGCCCCGCCACGCTTGTGTCTTTAGTGCTCCAAGTCTAGGAACTCCCTCAGATCCCAGT
TCCTTTAGAAAGCAGTTACCCAACAGAAACATTCTGGGCTGGGAACCAGGGAGGCGCCCTGGTTTGTTTTCCCCAGTTGTAATAGTGCCA
AGCAGGCCTGATTCTCGCGATTATTCTCGAATCACCTCCTGTGTTGTGCTGGGAGCAGGACTGATTGAATTACGGAAAATGCCTGTAAAG
TCTGAGTAAGAAACTTCATGCTGGCCTGTGTGATACAAGAGTCAGCATCATTAAAGGAAACGTGGCAGGACTTCCATCTGTGCCATACTT
GTTCTGTATTCGAAATGAGCTCAAATTGATTTTTTAATTTCTATGAAGGATCCATCTTTGTATATTTACATGCTTAGAGGGGTGAAAATT
ATTTTGGAAATTGAGTCTGAAGCACTCTCGCACACACAGTGATTCCCTCCTCCCGTCACTCCACGCAGCTGGCAGAGAGCACAGTGATCA
CCAGCGTGAGTGGTGGAGGAGGACACTTGGATTTTTTTTTTTGTTTTTTTTTTTTTTGCTTAACAGTTTTAGAATACATTGTACTTATAC
ACCTTATTAATGATCAGCTATATACTATTTATATACAAGTGATAATACAGATTTGTAACATTAGTTTTAAAAAGGGAAAGTTTTGTTCTG
TATATTTTGTTACCTTTTACAGAATAAAAGAATTACATATGAAAAACCCTCTAAACCATGGCACTTGATGTGATGTGGCAGGAGGGCAGT
GGTGGAGCTGGACCTGCCTGCTGCAGTCACGTGTAAACAGGATTATTATTAGTGTTTTATGCATGTAATGGACTATGCACACTTTTAATT
TTGTCAGATTCACACATGCCACTATGAGCTTTCAGACTCCAGCTGTGAAGAGACTCTGTTTGCTTGTGTTTGTTTGTTTGCAGTCTCTCT
CTGCCATGGCCTTGGCAGGCTGCTGGAAGGCAGCTTGTGGAGGCCGTTGGTTCCGCCCACTCATTCCTTCTCGTGCACTGCTTTCTCCTT

>44787_44787_2_LIN9-EZR_LIN9_chr1_226485419_ENST00000328205_EZR_chr6_159210403_ENST00000367075_length(amino acids)=785AA_BP=203
MRPRTEGFFPPAGASLPFSTRNKQPAVPAAAARAAEHAPGAGPGRDSGAGTAPPALRRRASPCGLLPPFLPPGSAGGGGGGARRGPPSAA
PPPRAGAGGAGPASASRGGSSAARRRGQRAPHSNLPRKDSLRPTMHRGGQPLKKRRGSFKMAELDQLPDESSSAKALVSLKEGSLSNTWN
EKYSSLQKTPVWKGRNTSSAVEMINVRVTTMDAELEFAIQPNTTGKQLFDQVVKTIGLREVWYFGLHYVDNKGFPTWLKLDKKVSAQEVR
KENPLQFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYCPPETAVLLGSYAVQAKFGDYNKEVHKSGYLSSERLIPQRVMDQH
KLTRDQWEDRIQVWHAEHRGMLKDNAMLEYLKIAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGFPWSEIRNISFN
DKKFVIKPIDKKAPDFVFYAPRLRINKRILQLCMGNHELYMRRRKPDTIEVQQMKAQAREEKHQKQLERQQLETEKKRRETVEREKEQMM
REKEELMLRLQDYEEKTKKAERELSEQIQRALQLEEERKRAQEEAERLEADRMAALRAKEELERQAVDQIKSQEQLAAELAEYTAKIALL
EEARRRKEDEVEEWQHRAKEAQDDLVKTKEELHLVMTAPPPPPPPVYEPVSYHVQESLQDEGAEPTGYSAELSSEGIRDDRNEEKRITEA

--------------------------------------------------------------
>44787_44787_3_LIN9-EZR_LIN9_chr1_226485419_ENST00000328205_EZR_chr6_159210403_ENST00000392177_length(transcript)=2424nt_BP=753nt
GCTGGGACCGAGTCCCGGACGTCGCGACGCGCAGGGGGCTGCTGCGGCCGGCGGTCTCGGGAAAAGTGAGGGGACGGAGGCGCCCAAGCA
ACGTGGGTTTCGGGAACTGTGAGTATTTCACTTTGCGTAGAGCCCCCTCGGGCAATGCGACCCAGAACCGAGGGCTTCTTTCCCCCCGCC
GGGGCCTCCCTCCCGTTCTCCACTCGGAACAAACAGCCTGCAGTTCCCGCAGCTGCAGCGCGGGCCGCGGAACATGCGCCGGGAGCGGGG
CCCGGGCGGGACTCCGGAGCTGGTACTGCTCCCCCCGCGCTCCGGCGCCGGGCCTCGCCGTGCGGCCTCCTTCCTCCCTTCCTCCCGCCC
GGCTCGGCCGGAGGCGGCGGCGGAGGGGCGAGGCGCGGCCCCCCTTCGGCGGCACCTCCTCCCCGGGCAGGCGCGGGCGGAGCCGGGCCC
GCCTCAGCCAGCCGCGGCGGGAGCAGCGCAGCGCGGCGCCGCGGGCAGCGAGCTCCGCATTCGAACCTCCCTCGCAAAGACAGTCTCCGC
CCCACAATGCACCGCGGCGGGCAGCCTTTGAAAAAGCGGCGCGGCTCGTTCAAGATGGCGGAGCTCGACCAGTTGCCTGACGAGAGCTCT
TCAGCAAAAGCCCTTGTCAGTTTAAAAGAAGGAAGCTTATCTAACACGTGGAATGAAAAGTACAGTTCTTTACAGAAAACACCTGTTTGG
AAAGGCAGGAATACAAGCTCTGCTGTGGAAATGATCAATGTCCGAGTTACCACCATGGATGCAGAGCTGGAGTTTGCAATCCAGCCAAAT
ACAACTGGAAAACAGCTTTTTGATCAGGTGTCTGCCCAGGAGGTCAGGAAGGAGAATCCCCTCCAGTTCAAGTTCCGGGCCAAGTTCTAC
CCTGAAGATGTGGCTGAGGAGCTCATCCAGGACATCACCCAGAAACTTTTCTTCCTCCAAGTGAAGGAAGGAATCCTTAGCGATGAGATC
TACTGCCCCCCTGAGACTGCCGTGCTCTTGGGGTCCTACGCTGTGCAGGCCAAGTTTGGGGACTACAACAAAGAAGTGCACAAGTCTGGG
TACCTCAGCTCTGAGCGGCTGATCCCTCAAAGAGTGATGGACCAGCACAAACTTACCAGGGACCAGTGGGAGGACCGGATCCAGGTGTGG
CATGCGGAACACCGTGGGATGCTCAAAGATAATGCTATGTTGGAATACCTGAAGATTGCTCAGGACCTGGAAATGTATGGAATCAACTAT
TTCGAGATAAAAAACAAGAAAGGAACAGACCTTTGGCTTGGAGTTGATGCCCTTGGACTGAATATTTATGAGAAAGATGATAAGTTAACC
CCAAAGATTGGCTTTCCTTGGAGTGAAATCAGGAACATCTCTTTCAATGACAAAAAGTTTGTCATTAAACCCATCGACAAGAAGGCACCT
GACTTTGTGTTTTATGCCCCACGTCTGAGAATCAACAAGCGGATCCTGCAGCTCTGCATGGGCAACCATGAGTTGTATATGCGCCGCAGG
AAGCCTGACACCATCGAGGTGCAGCAGATGAAGGCCCAGGCCCGGGAGGAGAAGCATCAGAAGCAGCTGGAGCGGCAACAGCTGGAAACA
GAGAAGAAAAGGAGAGAAACCGTGGAGAGAGAGAAAGAGCAGATGATGCGCGAGAAGGAGGAGTTGATGCTGCGGCTGCAGGACTATGAG
GAGAAGACAAAGAAGGCAGAGAGAGAGCTCTCGGAGCAGATTCAGAGGGCCCTGCAGCTGGAGGAGGAGAGGAAGCGGGCACAGGAGGAG
GCCGAGCGCCTAGAGGCTGACCGTATGGCTGCACTGCGGGCTAAGGAGGAGCTGGAGAGACAGGCGGTGGATCAGATAAAGAGCCAGGAG
CAGCTGGCTGCGGAGCTTGCAGAATACACTGCCAAGATTGCCCTCCTGGAAGAGGCGCGGAGGCGCAAGGAGGATGAAGTTGAAGAGTGG
CAGCACAGGGCCAAAGAAGCCCAGGATGACCTGGTGAAGACCAAGGAGGAGCTGCACCTGGTGATGACAGCACCCCCGCCCCCACCACCC
CCCGTGTACGAGCCGGTGAGCTACCATGTCCAGGAGAGCTTGCAGGATGAGGGCGCAGAGCCCACGGGCTACAGCGCGGAGCTGTCTAGT
GAGGGCATCCGGGATGACCGCAATGAGGAGAAGCGCATCACTGAGGCAGAGAAGAACGAGCGTGTGCAGCGGCAGCTGCTGACGCTGAGC
AGCGAGCTGTCCCAGGCCCGAGATGAGAATAAGAGGACCCACAATGACATCATCCACAACGAGAACATGAGGCAAGGCCGGGACAAGTAC

>44787_44787_3_LIN9-EZR_LIN9_chr1_226485419_ENST00000328205_EZR_chr6_159210403_ENST00000392177_length(amino acids)=753AA_BP=203
MRPRTEGFFPPAGASLPFSTRNKQPAVPAAAARAAEHAPGAGPGRDSGAGTAPPALRRRASPCGLLPPFLPPGSAGGGGGGARRGPPSAA
PPPRAGAGGAGPASASRGGSSAARRRGQRAPHSNLPRKDSLRPTMHRGGQPLKKRRGSFKMAELDQLPDESSSAKALVSLKEGSLSNTWN
EKYSSLQKTPVWKGRNTSSAVEMINVRVTTMDAELEFAIQPNTTGKQLFDQVSAQEVRKENPLQFKFRAKFYPEDVAEELIQDITQKLFF
LQVKEGILSDEIYCPPETAVLLGSYAVQAKFGDYNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWHAEHRGMLKDNAMLEYLK
IAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGFPWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILQL
CMGNHELYMRRRKPDTIEVQQMKAQAREEKHQKQLERQQLETEKKRRETVEREKEQMMREKEELMLRLQDYEEKTKKAERELSEQIQRAL
QLEEERKRAQEEAERLEADRMAALRAKEELERQAVDQIKSQEQLAAELAEYTAKIALLEEARRRKEDEVEEWQHRAKEAQDDLVKTKEEL
HLVMTAPPPPPPPVYEPVSYHVQESLQDEGAEPTGYSAELSSEGIRDDRNEEKRITEAEKNERVQRQLLTLSSELSQARDENKRTHNDII

--------------------------------------------------------------
>44787_44787_4_LIN9-EZR_LIN9_chr1_226485419_ENST00000366801_EZR_chr6_159210403_ENST00000337147_length(transcript)=3439nt_BP=517nt
AGCGCGGGCCGCGGAACATGCGCCGGGAGCGGGGCCCGGGCGGGACTCCGGAGCTGGTACTGCTCCCCCCGCGCTCCGGCGCCGGGCCTC
GCCGTGCGGCCTCCTTCCTCCCTTCCTCCCGCCCGGCTCGGCCGGAGGCGGCGGCGGAGGGGCGAGGCGCGGCCCCCCTTCGGCGGCACC
TCCTCCCCGGGCAGGCGCGGGCGGAGCCGGGCCCGCCTCAGCCAGCCGCGGCGGGAGCAGCGCAGCGCGGCGCCGCGGGCAGCGAGCTCC
GCATTCGAACCTCCCTCGCAAAGACAGTCTCCGCCCCACAATGCACCGCGGCGGGCAGCCTTTGAAAAAGCGGCGCGGCTCGTTCAAGAT
GGCGGAGCTCGACCAGTTGCCTGACGAGAGCTCTTCAGCAAAAGCCCTTGTCAGTTTAAAAGAAGGAAGCTTATCTAACACGTGGAATGA
AAAGTACAGTTCTTTACAGAAAACACCTGTTTGGAAAGGCAGGAATACAAGCTCTGCTGTGGAAATGATCAATGTCCGAGTTACCACCAT
GGATGCAGAGCTGGAGTTTGCAATCCAGCCAAATACAACTGGAAAACAGCTTTTTGATCAGGTGGTAAAGACTATCGGCCTCCGGGAAGT
GTGGTACTTTGGCCTCCACTATGTGGATAATAAAGGATTTCCTACCTGGCTGAAGCTGGATAAGAAGGTGTCTGCCCAGGAGGTCAGGAA
GGAGAATCCCCTCCAGTTCAAGTTCCGGGCCAAGTTCTACCCTGAAGATGTGGCTGAGGAGCTCATCCAGGACATCACCCAGAAACTTTT
CTTCCTCCAAGTGAAGGAAGGAATCCTTAGCGATGAGATCTACTGCCCCCCTGAGACTGCCGTGCTCTTGGGGTCCTACGCTGTGCAGGC
CAAGTTTGGGGACTACAACAAAGAAGTGCACAAGTCTGGGTACCTCAGCTCTGAGCGGCTGATCCCTCAAAGAGTGATGGACCAGCACAA
ACTTACCAGGGACCAGTGGGAGGACCGGATCCAGGTGTGGCATGCGGAACACCGTGGGATGCTCAAAGATAATGCTATGTTGGAATACCT
GAAGATTGCTCAGGACCTGGAAATGTATGGAATCAACTATTTCGAGATAAAAAACAAGAAAGGAACAGACCTTTGGCTTGGAGTTGATGC
CCTTGGACTGAATATTTATGAGAAAGATGATAAGTTAACCCCAAAGATTGGCTTTCCTTGGAGTGAAATCAGGAACATCTCTTTCAATGA
CAAAAAGTTTGTCATTAAACCCATCGACAAGAAGGCACCTGACTTTGTGTTTTATGCCCCACGTCTGAGAATCAACAAGCGGATCCTGCA
GCTCTGCATGGGCAACCATGAGTTGTATATGCGCCGCAGGAAGCCTGACACCATCGAGGTGCAGCAGATGAAGGCCCAGGCCCGGGAGGA
GAAGCATCAGAAGCAGCTGGAGCGGCAACAGCTGGAAACAGAGAAGAAAAGGAGAGAAACCGTGGAGAGAGAGAAAGAGCAGATGATGCG
CGAGAAGGAGGAGTTGATGCTGCGGCTGCAGGACTATGAGGAGAAGACAAAGAAGGCAGAGAGAGAGCTCTCGGAGCAGATTCAGAGGGC
CCTGCAGCTGGAGGAGGAGAGGAAGCGGGCACAGGAGGAGGCCGAGCGCCTAGAGGCTGACCGTATGGCTGCACTGCGGGCTAAGGAGGA
GCTGGAGAGACAGGCGGTGGATCAGATAAAGAGCCAGGAGCAGCTGGCTGCGGAGCTTGCAGAATACACTGCCAAGATTGCCCTCCTGGA
AGAGGCGCGGAGGCGCAAGGAGGATGAAGTTGAAGAGTGGCAGCACAGGGCCAAAGAAGCCCAGGATGACCTGGTGAAGACCAAGGAGGA
GCTGCACCTGGTGATGACAGCACCCCCGCCCCCACCACCCCCCGTGTACGAGCCGGTGAGCTACCATGTCCAGGAGAGCTTGCAGGATGA
GGGCGCAGAGCCCACGGGCTACAGCGCGGAGCTGTCTAGTGAGGGCATCCGGGATGACCGCAATGAGGAGAAGCGCATCACTGAGGCAGA
GAAGAACGAGCGTGTGCAGCGGCAGCTGCTGACGCTGAGCAGCGAGCTGTCCCAGGCCCGAGATGAGAATAAGAGGACCCACAATGACAT
CATCCACAACGAGAACATGAGGCAAGGCCGGGACAAGTACAAGACGCTGCGGCAGATCCGGCAGGGCAACACCAAGCAGCGCATCGACGA
GTTCGAGGCCCTGTAACAGCCAGGCCAGGACCAAGGGCAGAGGGGTGCTCATAGCGGGCGCTGCCAGCCCCGCCACGCTTGTGTCTTTAG
TGCTCCAAGTCTAGGAACTCCCTCAGATCCCAGTTCCTTTAGAAAGCAGTTACCCAACAGAAACATTCTGGGCTGGGAACCAGGGAGGCG
CCCTGGTTTGTTTTCCCCAGTTGTAATAGTGCCAAGCAGGCCTGATTCTCGCGATTATTCTCGAATCACCTCCTGTGTTGTGCTGGGAGC
AGGACTGATTGAATTACGGAAAATGCCTGTAAAGTCTGAGTAAGAAACTTCATGCTGGCCTGTGTGATACAAGAGTCAGCATCATTAAAG
GAAACGTGGCAGGACTTCCATCTGTGCCATACTTGTTCTGTATTCGAAATGAGCTCAAATTGATTTTTTAATTTCTATGAAGGATCCATC
TTTGTATATTTACATGCTTAGAGGGGTGAAAATTATTTTGGAAATTGAGTCTGAAGCACTCTCGCACACACAGTGATTCCCTCCTCCCGT
CACTCCACGCAGCTGGCAGAGAGCACAGTGATCACCAGCGTGAGTGGTGGAGGAGGACACTTGGATTTTTTTTTTTGTTTTTTTTTTTTT
TGCTTAACAGTTTTAGAATACATTGTACTTATACACCTTATTAATGATCAGCTATATACTATTTATATACAAGTGATAATACAGATTTGT
AACATTAGTTTTAAAAAGGGAAAGTTTTGTTCTGTATATTTTGTTACCTTTTACAGAATAAAAGAATTACATATGAAAAACCCTCTAAAC
CATGGCACTTGATGTGATGTGGCAGGAGGGCAGTGGTGGAGCTGGACCTGCCTGCTGCAGTCACGTGTAAACAGGATTATTATTAGTGTT
TTATGCATGTAATGGACTATGCACACTTTTAATTTTGTCAGATTCACACATGCCACTATGAGCTTTCAGACTCCAGCTGTGAAGAGACTC
TGTTTGCTTGTGTTTGTTTGTTTGCAGTCTCTCTCTGCCATGGCCTTGGCAGGCTGCTGGAAGGCAGCTTGTGGAGGCCGTTGGTTCCGC
CCACTCATTCCTTCTCGTGCACTGCTTTCTCCTTCACAGCTAAGATGCCATGTGCAGGTGGATTCCATGCCGCAGACATGAAATAAAAGC

>44787_44787_4_LIN9-EZR_LIN9_chr1_226485419_ENST00000366801_EZR_chr6_159210403_ENST00000337147_length(amino acids)=651AA_BP=69
MHRGGQPLKKRRGSFKMAELDQLPDESSSAKALVSLKEGSLSNTWNEKYSSLQKTPVWKGRNTSSAVEMINVRVTTMDAELEFAIQPNTT
GKQLFDQVVKTIGLREVWYFGLHYVDNKGFPTWLKLDKKVSAQEVRKENPLQFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEI
YCPPETAVLLGSYAVQAKFGDYNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWHAEHRGMLKDNAMLEYLKIAQDLEMYGINY
FEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGFPWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILQLCMGNHELYMRRR
KPDTIEVQQMKAQAREEKHQKQLERQQLETEKKRRETVEREKEQMMREKEELMLRLQDYEEKTKKAERELSEQIQRALQLEEERKRAQEE
AERLEADRMAALRAKEELERQAVDQIKSQEQLAAELAEYTAKIALLEEARRRKEDEVEEWQHRAKEAQDDLVKTKEELHLVMTAPPPPPP
PVYEPVSYHVQESLQDEGAEPTGYSAELSSEGIRDDRNEEKRITEAEKNERVQRQLLTLSSELSQARDENKRTHNDIIHNENMRQGRDKY

--------------------------------------------------------------
>44787_44787_5_LIN9-EZR_LIN9_chr1_226485419_ENST00000366801_EZR_chr6_159210403_ENST00000367075_length(transcript)=3432nt_BP=517nt
AGCGCGGGCCGCGGAACATGCGCCGGGAGCGGGGCCCGGGCGGGACTCCGGAGCTGGTACTGCTCCCCCCGCGCTCCGGCGCCGGGCCTC
GCCGTGCGGCCTCCTTCCTCCCTTCCTCCCGCCCGGCTCGGCCGGAGGCGGCGGCGGAGGGGCGAGGCGCGGCCCCCCTTCGGCGGCACC
TCCTCCCCGGGCAGGCGCGGGCGGAGCCGGGCCCGCCTCAGCCAGCCGCGGCGGGAGCAGCGCAGCGCGGCGCCGCGGGCAGCGAGCTCC
GCATTCGAACCTCCCTCGCAAAGACAGTCTCCGCCCCACAATGCACCGCGGCGGGCAGCCTTTGAAAAAGCGGCGCGGCTCGTTCAAGAT
GGCGGAGCTCGACCAGTTGCCTGACGAGAGCTCTTCAGCAAAAGCCCTTGTCAGTTTAAAAGAAGGAAGCTTATCTAACACGTGGAATGA
AAAGTACAGTTCTTTACAGAAAACACCTGTTTGGAAAGGCAGGAATACAAGCTCTGCTGTGGAAATGATCAATGTCCGAGTTACCACCAT
GGATGCAGAGCTGGAGTTTGCAATCCAGCCAAATACAACTGGAAAACAGCTTTTTGATCAGGTGGTAAAGACTATCGGCCTCCGGGAAGT
GTGGTACTTTGGCCTCCACTATGTGGATAATAAAGGATTTCCTACCTGGCTGAAGCTGGATAAGAAGGTGTCTGCCCAGGAGGTCAGGAA
GGAGAATCCCCTCCAGTTCAAGTTCCGGGCCAAGTTCTACCCTGAAGATGTGGCTGAGGAGCTCATCCAGGACATCACCCAGAAACTTTT
CTTCCTCCAAGTGAAGGAAGGAATCCTTAGCGATGAGATCTACTGCCCCCCTGAGACTGCCGTGCTCTTGGGGTCCTACGCTGTGCAGGC
CAAGTTTGGGGACTACAACAAAGAAGTGCACAAGTCTGGGTACCTCAGCTCTGAGCGGCTGATCCCTCAAAGAGTGATGGACCAGCACAA
ACTTACCAGGGACCAGTGGGAGGACCGGATCCAGGTGTGGCATGCGGAACACCGTGGGATGCTCAAAGATAATGCTATGTTGGAATACCT
GAAGATTGCTCAGGACCTGGAAATGTATGGAATCAACTATTTCGAGATAAAAAACAAGAAAGGAACAGACCTTTGGCTTGGAGTTGATGC
CCTTGGACTGAATATTTATGAGAAAGATGATAAGTTAACCCCAAAGATTGGCTTTCCTTGGAGTGAAATCAGGAACATCTCTTTCAATGA
CAAAAAGTTTGTCATTAAACCCATCGACAAGAAGGCACCTGACTTTGTGTTTTATGCCCCACGTCTGAGAATCAACAAGCGGATCCTGCA
GCTCTGCATGGGCAACCATGAGTTGTATATGCGCCGCAGGAAGCCTGACACCATCGAGGTGCAGCAGATGAAGGCCCAGGCCCGGGAGGA
GAAGCATCAGAAGCAGCTGGAGCGGCAACAGCTGGAAACAGAGAAGAAAAGGAGAGAAACCGTGGAGAGAGAGAAAGAGCAGATGATGCG
CGAGAAGGAGGAGTTGATGCTGCGGCTGCAGGACTATGAGGAGAAGACAAAGAAGGCAGAGAGAGAGCTCTCGGAGCAGATTCAGAGGGC
CCTGCAGCTGGAGGAGGAGAGGAAGCGGGCACAGGAGGAGGCCGAGCGCCTAGAGGCTGACCGTATGGCTGCACTGCGGGCTAAGGAGGA
GCTGGAGAGACAGGCGGTGGATCAGATAAAGAGCCAGGAGCAGCTGGCTGCGGAGCTTGCAGAATACACTGCCAAGATTGCCCTCCTGGA
AGAGGCGCGGAGGCGCAAGGAGGATGAAGTTGAAGAGTGGCAGCACAGGGCCAAAGAAGCCCAGGATGACCTGGTGAAGACCAAGGAGGA
GCTGCACCTGGTGATGACAGCACCCCCGCCCCCACCACCCCCCGTGTACGAGCCGGTGAGCTACCATGTCCAGGAGAGCTTGCAGGATGA
GGGCGCAGAGCCCACGGGCTACAGCGCGGAGCTGTCTAGTGAGGGCATCCGGGATGACCGCAATGAGGAGAAGCGCATCACTGAGGCAGA
GAAGAACGAGCGTGTGCAGCGGCAGCTGCTGACGCTGAGCAGCGAGCTGTCCCAGGCCCGAGATGAGAATAAGAGGACCCACAATGACAT
CATCCACAACGAGAACATGAGGCAAGGCCGGGACAAGTACAAGACGCTGCGGCAGATCCGGCAGGGCAACACCAAGCAGCGCATCGACGA
GTTCGAGGCCCTGTAACAGCCAGGCCAGGACCAAGGGCAGAGGGGTGCTCATAGCGGGCGCTGCCAGCCCCGCCACGCTTGTGTCTTTAG
TGCTCCAAGTCTAGGAACTCCCTCAGATCCCAGTTCCTTTAGAAAGCAGTTACCCAACAGAAACATTCTGGGCTGGGAACCAGGGAGGCG
CCCTGGTTTGTTTTCCCCAGTTGTAATAGTGCCAAGCAGGCCTGATTCTCGCGATTATTCTCGAATCACCTCCTGTGTTGTGCTGGGAGC
AGGACTGATTGAATTACGGAAAATGCCTGTAAAGTCTGAGTAAGAAACTTCATGCTGGCCTGTGTGATACAAGAGTCAGCATCATTAAAG
GAAACGTGGCAGGACTTCCATCTGTGCCATACTTGTTCTGTATTCGAAATGAGCTCAAATTGATTTTTTAATTTCTATGAAGGATCCATC
TTTGTATATTTACATGCTTAGAGGGGTGAAAATTATTTTGGAAATTGAGTCTGAAGCACTCTCGCACACACAGTGATTCCCTCCTCCCGT
CACTCCACGCAGCTGGCAGAGAGCACAGTGATCACCAGCGTGAGTGGTGGAGGAGGACACTTGGATTTTTTTTTTTGTTTTTTTTTTTTT
TGCTTAACAGTTTTAGAATACATTGTACTTATACACCTTATTAATGATCAGCTATATACTATTTATATACAAGTGATAATACAGATTTGT
AACATTAGTTTTAAAAAGGGAAAGTTTTGTTCTGTATATTTTGTTACCTTTTACAGAATAAAAGAATTACATATGAAAAACCCTCTAAAC
CATGGCACTTGATGTGATGTGGCAGGAGGGCAGTGGTGGAGCTGGACCTGCCTGCTGCAGTCACGTGTAAACAGGATTATTATTAGTGTT
TTATGCATGTAATGGACTATGCACACTTTTAATTTTGTCAGATTCACACATGCCACTATGAGCTTTCAGACTCCAGCTGTGAAGAGACTC
TGTTTGCTTGTGTTTGTTTGTTTGCAGTCTCTCTCTGCCATGGCCTTGGCAGGCTGCTGGAAGGCAGCTTGTGGAGGCCGTTGGTTCCGC
CCACTCATTCCTTCTCGTGCACTGCTTTCTCCTTCACAGCTAAGATGCCATGTGCAGGTGGATTCCATGCCGCAGACATGAAATAAAAGC

>44787_44787_5_LIN9-EZR_LIN9_chr1_226485419_ENST00000366801_EZR_chr6_159210403_ENST00000367075_length(amino acids)=651AA_BP=69
MHRGGQPLKKRRGSFKMAELDQLPDESSSAKALVSLKEGSLSNTWNEKYSSLQKTPVWKGRNTSSAVEMINVRVTTMDAELEFAIQPNTT
GKQLFDQVVKTIGLREVWYFGLHYVDNKGFPTWLKLDKKVSAQEVRKENPLQFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEI
YCPPETAVLLGSYAVQAKFGDYNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWHAEHRGMLKDNAMLEYLKIAQDLEMYGINY
FEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGFPWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILQLCMGNHELYMRRR
KPDTIEVQQMKAQAREEKHQKQLERQQLETEKKRRETVEREKEQMMREKEELMLRLQDYEEKTKKAERELSEQIQRALQLEEERKRAQEE
AERLEADRMAALRAKEELERQAVDQIKSQEQLAAELAEYTAKIALLEEARRRKEDEVEEWQHRAKEAQDDLVKTKEELHLVMTAPPPPPP
PVYEPVSYHVQESLQDEGAEPTGYSAELSSEGIRDDRNEEKRITEAEKNERVQRQLLTLSSELSQARDENKRTHNDIIHNENMRQGRDKY

--------------------------------------------------------------
>44787_44787_6_LIN9-EZR_LIN9_chr1_226485419_ENST00000366801_EZR_chr6_159210403_ENST00000392177_length(transcript)=2188nt_BP=517nt
AGCGCGGGCCGCGGAACATGCGCCGGGAGCGGGGCCCGGGCGGGACTCCGGAGCTGGTACTGCTCCCCCCGCGCTCCGGCGCCGGGCCTC
GCCGTGCGGCCTCCTTCCTCCCTTCCTCCCGCCCGGCTCGGCCGGAGGCGGCGGCGGAGGGGCGAGGCGCGGCCCCCCTTCGGCGGCACC
TCCTCCCCGGGCAGGCGCGGGCGGAGCCGGGCCCGCCTCAGCCAGCCGCGGCGGGAGCAGCGCAGCGCGGCGCCGCGGGCAGCGAGCTCC
GCATTCGAACCTCCCTCGCAAAGACAGTCTCCGCCCCACAATGCACCGCGGCGGGCAGCCTTTGAAAAAGCGGCGCGGCTCGTTCAAGAT
GGCGGAGCTCGACCAGTTGCCTGACGAGAGCTCTTCAGCAAAAGCCCTTGTCAGTTTAAAAGAAGGAAGCTTATCTAACACGTGGAATGA
AAAGTACAGTTCTTTACAGAAAACACCTGTTTGGAAAGGCAGGAATACAAGCTCTGCTGTGGAAATGATCAATGTCCGAGTTACCACCAT
GGATGCAGAGCTGGAGTTTGCAATCCAGCCAAATACAACTGGAAAACAGCTTTTTGATCAGGTGTCTGCCCAGGAGGTCAGGAAGGAGAA
TCCCCTCCAGTTCAAGTTCCGGGCCAAGTTCTACCCTGAAGATGTGGCTGAGGAGCTCATCCAGGACATCACCCAGAAACTTTTCTTCCT
CCAAGTGAAGGAAGGAATCCTTAGCGATGAGATCTACTGCCCCCCTGAGACTGCCGTGCTCTTGGGGTCCTACGCTGTGCAGGCCAAGTT
TGGGGACTACAACAAAGAAGTGCACAAGTCTGGGTACCTCAGCTCTGAGCGGCTGATCCCTCAAAGAGTGATGGACCAGCACAAACTTAC
CAGGGACCAGTGGGAGGACCGGATCCAGGTGTGGCATGCGGAACACCGTGGGATGCTCAAAGATAATGCTATGTTGGAATACCTGAAGAT
TGCTCAGGACCTGGAAATGTATGGAATCAACTATTTCGAGATAAAAAACAAGAAAGGAACAGACCTTTGGCTTGGAGTTGATGCCCTTGG
ACTGAATATTTATGAGAAAGATGATAAGTTAACCCCAAAGATTGGCTTTCCTTGGAGTGAAATCAGGAACATCTCTTTCAATGACAAAAA
GTTTGTCATTAAACCCATCGACAAGAAGGCACCTGACTTTGTGTTTTATGCCCCACGTCTGAGAATCAACAAGCGGATCCTGCAGCTCTG
CATGGGCAACCATGAGTTGTATATGCGCCGCAGGAAGCCTGACACCATCGAGGTGCAGCAGATGAAGGCCCAGGCCCGGGAGGAGAAGCA
TCAGAAGCAGCTGGAGCGGCAACAGCTGGAAACAGAGAAGAAAAGGAGAGAAACCGTGGAGAGAGAGAAAGAGCAGATGATGCGCGAGAA
GGAGGAGTTGATGCTGCGGCTGCAGGACTATGAGGAGAAGACAAAGAAGGCAGAGAGAGAGCTCTCGGAGCAGATTCAGAGGGCCCTGCA
GCTGGAGGAGGAGAGGAAGCGGGCACAGGAGGAGGCCGAGCGCCTAGAGGCTGACCGTATGGCTGCACTGCGGGCTAAGGAGGAGCTGGA
GAGACAGGCGGTGGATCAGATAAAGAGCCAGGAGCAGCTGGCTGCGGAGCTTGCAGAATACACTGCCAAGATTGCCCTCCTGGAAGAGGC
GCGGAGGCGCAAGGAGGATGAAGTTGAAGAGTGGCAGCACAGGGCCAAAGAAGCCCAGGATGACCTGGTGAAGACCAAGGAGGAGCTGCA
CCTGGTGATGACAGCACCCCCGCCCCCACCACCCCCCGTGTACGAGCCGGTGAGCTACCATGTCCAGGAGAGCTTGCAGGATGAGGGCGC
AGAGCCCACGGGCTACAGCGCGGAGCTGTCTAGTGAGGGCATCCGGGATGACCGCAATGAGGAGAAGCGCATCACTGAGGCAGAGAAGAA
CGAGCGTGTGCAGCGGCAGCTGCTGACGCTGAGCAGCGAGCTGTCCCAGGCCCGAGATGAGAATAAGAGGACCCACAATGACATCATCCA
CAACGAGAACATGAGGCAAGGCCGGGACAAGTACAAGACGCTGCGGCAGATCCGGCAGGGCAACACCAAGCAGCGCATCGACGAGTTCGA

>44787_44787_6_LIN9-EZR_LIN9_chr1_226485419_ENST00000366801_EZR_chr6_159210403_ENST00000392177_length(amino acids)=619AA_BP=69
MHRGGQPLKKRRGSFKMAELDQLPDESSSAKALVSLKEGSLSNTWNEKYSSLQKTPVWKGRNTSSAVEMINVRVTTMDAELEFAIQPNTT
GKQLFDQVSAQEVRKENPLQFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYCPPETAVLLGSYAVQAKFGDYNKEVHKSGYL
SSERLIPQRVMDQHKLTRDQWEDRIQVWHAEHRGMLKDNAMLEYLKIAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPK
IGFPWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILQLCMGNHELYMRRRKPDTIEVQQMKAQAREEKHQKQLERQQLETEK
KRRETVEREKEQMMREKEELMLRLQDYEEKTKKAERELSEQIQRALQLEEERKRAQEEAERLEADRMAALRAKEELERQAVDQIKSQEQL
AAELAEYTAKIALLEEARRRKEDEVEEWQHRAKEAQDDLVKTKEELHLVMTAPPPPPPPVYEPVSYHVQESLQDEGAEPTGYSAELSSEG

--------------------------------------------------------------
>44787_44787_7_LIN9-EZR_LIN9_chr1_226485419_ENST00000481685_EZR_chr6_159210403_ENST00000337147_length(transcript)=3196nt_BP=274nt
AGCGCGGCGCCGCGGGCAGCGAGCTCCGCATTCGAACCTCCCTCGCAAAGACAGTCTCCGCCCCACAATGCACCGCGGCGGGCAGCCTTT
GAAAAAGCGGCGCGGCTCGTTCAAGATGGCGGAGCTCGACCAGTTGCCTGACGAGAGCTCTTCAGCAAAAGCCCTTGTCAGTTTAAAAGA
AGGAAGCTTATCTAACACGTGGAATGAAAAGTACAGTTCTTTACAGAAAACACCTGTTTGGAAAGGCAGGAATACAAGCTCTGCTGTGGA
AATGATCAATGTCCGAGTTACCACCATGGATGCAGAGCTGGAGTTTGCAATCCAGCCAAATACAACTGGAAAACAGCTTTTTGATCAGGT
GGTAAAGACTATCGGCCTCCGGGAAGTGTGGTACTTTGGCCTCCACTATGTGGATAATAAAGGATTTCCTACCTGGCTGAAGCTGGATAA
GAAGGTGTCTGCCCAGGAGGTCAGGAAGGAGAATCCCCTCCAGTTCAAGTTCCGGGCCAAGTTCTACCCTGAAGATGTGGCTGAGGAGCT
CATCCAGGACATCACCCAGAAACTTTTCTTCCTCCAAGTGAAGGAAGGAATCCTTAGCGATGAGATCTACTGCCCCCCTGAGACTGCCGT
GCTCTTGGGGTCCTACGCTGTGCAGGCCAAGTTTGGGGACTACAACAAAGAAGTGCACAAGTCTGGGTACCTCAGCTCTGAGCGGCTGAT
CCCTCAAAGAGTGATGGACCAGCACAAACTTACCAGGGACCAGTGGGAGGACCGGATCCAGGTGTGGCATGCGGAACACCGTGGGATGCT
CAAAGATAATGCTATGTTGGAATACCTGAAGATTGCTCAGGACCTGGAAATGTATGGAATCAACTATTTCGAGATAAAAAACAAGAAAGG
AACAGACCTTTGGCTTGGAGTTGATGCCCTTGGACTGAATATTTATGAGAAAGATGATAAGTTAACCCCAAAGATTGGCTTTCCTTGGAG
TGAAATCAGGAACATCTCTTTCAATGACAAAAAGTTTGTCATTAAACCCATCGACAAGAAGGCACCTGACTTTGTGTTTTATGCCCCACG
TCTGAGAATCAACAAGCGGATCCTGCAGCTCTGCATGGGCAACCATGAGTTGTATATGCGCCGCAGGAAGCCTGACACCATCGAGGTGCA
GCAGATGAAGGCCCAGGCCCGGGAGGAGAAGCATCAGAAGCAGCTGGAGCGGCAACAGCTGGAAACAGAGAAGAAAAGGAGAGAAACCGT
GGAGAGAGAGAAAGAGCAGATGATGCGCGAGAAGGAGGAGTTGATGCTGCGGCTGCAGGACTATGAGGAGAAGACAAAGAAGGCAGAGAG
AGAGCTCTCGGAGCAGATTCAGAGGGCCCTGCAGCTGGAGGAGGAGAGGAAGCGGGCACAGGAGGAGGCCGAGCGCCTAGAGGCTGACCG
TATGGCTGCACTGCGGGCTAAGGAGGAGCTGGAGAGACAGGCGGTGGATCAGATAAAGAGCCAGGAGCAGCTGGCTGCGGAGCTTGCAGA
ATACACTGCCAAGATTGCCCTCCTGGAAGAGGCGCGGAGGCGCAAGGAGGATGAAGTTGAAGAGTGGCAGCACAGGGCCAAAGAAGCCCA
GGATGACCTGGTGAAGACCAAGGAGGAGCTGCACCTGGTGATGACAGCACCCCCGCCCCCACCACCCCCCGTGTACGAGCCGGTGAGCTA
CCATGTCCAGGAGAGCTTGCAGGATGAGGGCGCAGAGCCCACGGGCTACAGCGCGGAGCTGTCTAGTGAGGGCATCCGGGATGACCGCAA
TGAGGAGAAGCGCATCACTGAGGCAGAGAAGAACGAGCGTGTGCAGCGGCAGCTGCTGACGCTGAGCAGCGAGCTGTCCCAGGCCCGAGA
TGAGAATAAGAGGACCCACAATGACATCATCCACAACGAGAACATGAGGCAAGGCCGGGACAAGTACAAGACGCTGCGGCAGATCCGGCA
GGGCAACACCAAGCAGCGCATCGACGAGTTCGAGGCCCTGTAACAGCCAGGCCAGGACCAAGGGCAGAGGGGTGCTCATAGCGGGCGCTG
CCAGCCCCGCCACGCTTGTGTCTTTAGTGCTCCAAGTCTAGGAACTCCCTCAGATCCCAGTTCCTTTAGAAAGCAGTTACCCAACAGAAA
CATTCTGGGCTGGGAACCAGGGAGGCGCCCTGGTTTGTTTTCCCCAGTTGTAATAGTGCCAAGCAGGCCTGATTCTCGCGATTATTCTCG
AATCACCTCCTGTGTTGTGCTGGGAGCAGGACTGATTGAATTACGGAAAATGCCTGTAAAGTCTGAGTAAGAAACTTCATGCTGGCCTGT
GTGATACAAGAGTCAGCATCATTAAAGGAAACGTGGCAGGACTTCCATCTGTGCCATACTTGTTCTGTATTCGAAATGAGCTCAAATTGA
TTTTTTAATTTCTATGAAGGATCCATCTTTGTATATTTACATGCTTAGAGGGGTGAAAATTATTTTGGAAATTGAGTCTGAAGCACTCTC
GCACACACAGTGATTCCCTCCTCCCGTCACTCCACGCAGCTGGCAGAGAGCACAGTGATCACCAGCGTGAGTGGTGGAGGAGGACACTTG
GATTTTTTTTTTTGTTTTTTTTTTTTTTGCTTAACAGTTTTAGAATACATTGTACTTATACACCTTATTAATGATCAGCTATATACTATT
TATATACAAGTGATAATACAGATTTGTAACATTAGTTTTAAAAAGGGAAAGTTTTGTTCTGTATATTTTGTTACCTTTTACAGAATAAAA
GAATTACATATGAAAAACCCTCTAAACCATGGCACTTGATGTGATGTGGCAGGAGGGCAGTGGTGGAGCTGGACCTGCCTGCTGCAGTCA
CGTGTAAACAGGATTATTATTAGTGTTTTATGCATGTAATGGACTATGCACACTTTTAATTTTGTCAGATTCACACATGCCACTATGAGC
TTTCAGACTCCAGCTGTGAAGAGACTCTGTTTGCTTGTGTTTGTTTGTTTGCAGTCTCTCTCTGCCATGGCCTTGGCAGGCTGCTGGAAG
GCAGCTTGTGGAGGCCGTTGGTTCCGCCCACTCATTCCTTCTCGTGCACTGCTTTCTCCTTCACAGCTAAGATGCCATGTGCAGGTGGAT

>44787_44787_7_LIN9-EZR_LIN9_chr1_226485419_ENST00000481685_EZR_chr6_159210403_ENST00000337147_length(amino acids)=651AA_BP=69
MHRGGQPLKKRRGSFKMAELDQLPDESSSAKALVSLKEGSLSNTWNEKYSSLQKTPVWKGRNTSSAVEMINVRVTTMDAELEFAIQPNTT
GKQLFDQVVKTIGLREVWYFGLHYVDNKGFPTWLKLDKKVSAQEVRKENPLQFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEI
YCPPETAVLLGSYAVQAKFGDYNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWHAEHRGMLKDNAMLEYLKIAQDLEMYGINY
FEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGFPWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILQLCMGNHELYMRRR
KPDTIEVQQMKAQAREEKHQKQLERQQLETEKKRRETVEREKEQMMREKEELMLRLQDYEEKTKKAERELSEQIQRALQLEEERKRAQEE
AERLEADRMAALRAKEELERQAVDQIKSQEQLAAELAEYTAKIALLEEARRRKEDEVEEWQHRAKEAQDDLVKTKEELHLVMTAPPPPPP
PVYEPVSYHVQESLQDEGAEPTGYSAELSSEGIRDDRNEEKRITEAEKNERVQRQLLTLSSELSQARDENKRTHNDIIHNENMRQGRDKY

--------------------------------------------------------------
>44787_44787_8_LIN9-EZR_LIN9_chr1_226485419_ENST00000481685_EZR_chr6_159210403_ENST00000367075_length(transcript)=3189nt_BP=274nt
AGCGCGGCGCCGCGGGCAGCGAGCTCCGCATTCGAACCTCCCTCGCAAAGACAGTCTCCGCCCCACAATGCACCGCGGCGGGCAGCCTTT
GAAAAAGCGGCGCGGCTCGTTCAAGATGGCGGAGCTCGACCAGTTGCCTGACGAGAGCTCTTCAGCAAAAGCCCTTGTCAGTTTAAAAGA
AGGAAGCTTATCTAACACGTGGAATGAAAAGTACAGTTCTTTACAGAAAACACCTGTTTGGAAAGGCAGGAATACAAGCTCTGCTGTGGA
AATGATCAATGTCCGAGTTACCACCATGGATGCAGAGCTGGAGTTTGCAATCCAGCCAAATACAACTGGAAAACAGCTTTTTGATCAGGT
GGTAAAGACTATCGGCCTCCGGGAAGTGTGGTACTTTGGCCTCCACTATGTGGATAATAAAGGATTTCCTACCTGGCTGAAGCTGGATAA
GAAGGTGTCTGCCCAGGAGGTCAGGAAGGAGAATCCCCTCCAGTTCAAGTTCCGGGCCAAGTTCTACCCTGAAGATGTGGCTGAGGAGCT
CATCCAGGACATCACCCAGAAACTTTTCTTCCTCCAAGTGAAGGAAGGAATCCTTAGCGATGAGATCTACTGCCCCCCTGAGACTGCCGT
GCTCTTGGGGTCCTACGCTGTGCAGGCCAAGTTTGGGGACTACAACAAAGAAGTGCACAAGTCTGGGTACCTCAGCTCTGAGCGGCTGAT
CCCTCAAAGAGTGATGGACCAGCACAAACTTACCAGGGACCAGTGGGAGGACCGGATCCAGGTGTGGCATGCGGAACACCGTGGGATGCT
CAAAGATAATGCTATGTTGGAATACCTGAAGATTGCTCAGGACCTGGAAATGTATGGAATCAACTATTTCGAGATAAAAAACAAGAAAGG
AACAGACCTTTGGCTTGGAGTTGATGCCCTTGGACTGAATATTTATGAGAAAGATGATAAGTTAACCCCAAAGATTGGCTTTCCTTGGAG
TGAAATCAGGAACATCTCTTTCAATGACAAAAAGTTTGTCATTAAACCCATCGACAAGAAGGCACCTGACTTTGTGTTTTATGCCCCACG
TCTGAGAATCAACAAGCGGATCCTGCAGCTCTGCATGGGCAACCATGAGTTGTATATGCGCCGCAGGAAGCCTGACACCATCGAGGTGCA
GCAGATGAAGGCCCAGGCCCGGGAGGAGAAGCATCAGAAGCAGCTGGAGCGGCAACAGCTGGAAACAGAGAAGAAAAGGAGAGAAACCGT
GGAGAGAGAGAAAGAGCAGATGATGCGCGAGAAGGAGGAGTTGATGCTGCGGCTGCAGGACTATGAGGAGAAGACAAAGAAGGCAGAGAG
AGAGCTCTCGGAGCAGATTCAGAGGGCCCTGCAGCTGGAGGAGGAGAGGAAGCGGGCACAGGAGGAGGCCGAGCGCCTAGAGGCTGACCG
TATGGCTGCACTGCGGGCTAAGGAGGAGCTGGAGAGACAGGCGGTGGATCAGATAAAGAGCCAGGAGCAGCTGGCTGCGGAGCTTGCAGA
ATACACTGCCAAGATTGCCCTCCTGGAAGAGGCGCGGAGGCGCAAGGAGGATGAAGTTGAAGAGTGGCAGCACAGGGCCAAAGAAGCCCA
GGATGACCTGGTGAAGACCAAGGAGGAGCTGCACCTGGTGATGACAGCACCCCCGCCCCCACCACCCCCCGTGTACGAGCCGGTGAGCTA
CCATGTCCAGGAGAGCTTGCAGGATGAGGGCGCAGAGCCCACGGGCTACAGCGCGGAGCTGTCTAGTGAGGGCATCCGGGATGACCGCAA
TGAGGAGAAGCGCATCACTGAGGCAGAGAAGAACGAGCGTGTGCAGCGGCAGCTGCTGACGCTGAGCAGCGAGCTGTCCCAGGCCCGAGA
TGAGAATAAGAGGACCCACAATGACATCATCCACAACGAGAACATGAGGCAAGGCCGGGACAAGTACAAGACGCTGCGGCAGATCCGGCA
GGGCAACACCAAGCAGCGCATCGACGAGTTCGAGGCCCTGTAACAGCCAGGCCAGGACCAAGGGCAGAGGGGTGCTCATAGCGGGCGCTG
CCAGCCCCGCCACGCTTGTGTCTTTAGTGCTCCAAGTCTAGGAACTCCCTCAGATCCCAGTTCCTTTAGAAAGCAGTTACCCAACAGAAA
CATTCTGGGCTGGGAACCAGGGAGGCGCCCTGGTTTGTTTTCCCCAGTTGTAATAGTGCCAAGCAGGCCTGATTCTCGCGATTATTCTCG
AATCACCTCCTGTGTTGTGCTGGGAGCAGGACTGATTGAATTACGGAAAATGCCTGTAAAGTCTGAGTAAGAAACTTCATGCTGGCCTGT
GTGATACAAGAGTCAGCATCATTAAAGGAAACGTGGCAGGACTTCCATCTGTGCCATACTTGTTCTGTATTCGAAATGAGCTCAAATTGA
TTTTTTAATTTCTATGAAGGATCCATCTTTGTATATTTACATGCTTAGAGGGGTGAAAATTATTTTGGAAATTGAGTCTGAAGCACTCTC
GCACACACAGTGATTCCCTCCTCCCGTCACTCCACGCAGCTGGCAGAGAGCACAGTGATCACCAGCGTGAGTGGTGGAGGAGGACACTTG
GATTTTTTTTTTTGTTTTTTTTTTTTTTGCTTAACAGTTTTAGAATACATTGTACTTATACACCTTATTAATGATCAGCTATATACTATT
TATATACAAGTGATAATACAGATTTGTAACATTAGTTTTAAAAAGGGAAAGTTTTGTTCTGTATATTTTGTTACCTTTTACAGAATAAAA
GAATTACATATGAAAAACCCTCTAAACCATGGCACTTGATGTGATGTGGCAGGAGGGCAGTGGTGGAGCTGGACCTGCCTGCTGCAGTCA
CGTGTAAACAGGATTATTATTAGTGTTTTATGCATGTAATGGACTATGCACACTTTTAATTTTGTCAGATTCACACATGCCACTATGAGC
TTTCAGACTCCAGCTGTGAAGAGACTCTGTTTGCTTGTGTTTGTTTGTTTGCAGTCTCTCTCTGCCATGGCCTTGGCAGGCTGCTGGAAG
GCAGCTTGTGGAGGCCGTTGGTTCCGCCCACTCATTCCTTCTCGTGCACTGCTTTCTCCTTCACAGCTAAGATGCCATGTGCAGGTGGAT

>44787_44787_8_LIN9-EZR_LIN9_chr1_226485419_ENST00000481685_EZR_chr6_159210403_ENST00000367075_length(amino acids)=651AA_BP=69
MHRGGQPLKKRRGSFKMAELDQLPDESSSAKALVSLKEGSLSNTWNEKYSSLQKTPVWKGRNTSSAVEMINVRVTTMDAELEFAIQPNTT
GKQLFDQVVKTIGLREVWYFGLHYVDNKGFPTWLKLDKKVSAQEVRKENPLQFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEI
YCPPETAVLLGSYAVQAKFGDYNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWHAEHRGMLKDNAMLEYLKIAQDLEMYGINY
FEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGFPWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILQLCMGNHELYMRRR
KPDTIEVQQMKAQAREEKHQKQLERQQLETEKKRRETVEREKEQMMREKEELMLRLQDYEEKTKKAERELSEQIQRALQLEEERKRAQEE
AERLEADRMAALRAKEELERQAVDQIKSQEQLAAELAEYTAKIALLEEARRRKEDEVEEWQHRAKEAQDDLVKTKEELHLVMTAPPPPPP
PVYEPVSYHVQESLQDEGAEPTGYSAELSSEGIRDDRNEEKRITEAEKNERVQRQLLTLSSELSQARDENKRTHNDIIHNENMRQGRDKY

--------------------------------------------------------------
>44787_44787_9_LIN9-EZR_LIN9_chr1_226485419_ENST00000481685_EZR_chr6_159210403_ENST00000392177_length(transcript)=1945nt_BP=274nt
AGCGCGGCGCCGCGGGCAGCGAGCTCCGCATTCGAACCTCCCTCGCAAAGACAGTCTCCGCCCCACAATGCACCGCGGCGGGCAGCCTTT
GAAAAAGCGGCGCGGCTCGTTCAAGATGGCGGAGCTCGACCAGTTGCCTGACGAGAGCTCTTCAGCAAAAGCCCTTGTCAGTTTAAAAGA
AGGAAGCTTATCTAACACGTGGAATGAAAAGTACAGTTCTTTACAGAAAACACCTGTTTGGAAAGGCAGGAATACAAGCTCTGCTGTGGA
AATGATCAATGTCCGAGTTACCACCATGGATGCAGAGCTGGAGTTTGCAATCCAGCCAAATACAACTGGAAAACAGCTTTTTGATCAGGT
GTCTGCCCAGGAGGTCAGGAAGGAGAATCCCCTCCAGTTCAAGTTCCGGGCCAAGTTCTACCCTGAAGATGTGGCTGAGGAGCTCATCCA
GGACATCACCCAGAAACTTTTCTTCCTCCAAGTGAAGGAAGGAATCCTTAGCGATGAGATCTACTGCCCCCCTGAGACTGCCGTGCTCTT
GGGGTCCTACGCTGTGCAGGCCAAGTTTGGGGACTACAACAAAGAAGTGCACAAGTCTGGGTACCTCAGCTCTGAGCGGCTGATCCCTCA
AAGAGTGATGGACCAGCACAAACTTACCAGGGACCAGTGGGAGGACCGGATCCAGGTGTGGCATGCGGAACACCGTGGGATGCTCAAAGA
TAATGCTATGTTGGAATACCTGAAGATTGCTCAGGACCTGGAAATGTATGGAATCAACTATTTCGAGATAAAAAACAAGAAAGGAACAGA
CCTTTGGCTTGGAGTTGATGCCCTTGGACTGAATATTTATGAGAAAGATGATAAGTTAACCCCAAAGATTGGCTTTCCTTGGAGTGAAAT
CAGGAACATCTCTTTCAATGACAAAAAGTTTGTCATTAAACCCATCGACAAGAAGGCACCTGACTTTGTGTTTTATGCCCCACGTCTGAG
AATCAACAAGCGGATCCTGCAGCTCTGCATGGGCAACCATGAGTTGTATATGCGCCGCAGGAAGCCTGACACCATCGAGGTGCAGCAGAT
GAAGGCCCAGGCCCGGGAGGAGAAGCATCAGAAGCAGCTGGAGCGGCAACAGCTGGAAACAGAGAAGAAAAGGAGAGAAACCGTGGAGAG
AGAGAAAGAGCAGATGATGCGCGAGAAGGAGGAGTTGATGCTGCGGCTGCAGGACTATGAGGAGAAGACAAAGAAGGCAGAGAGAGAGCT
CTCGGAGCAGATTCAGAGGGCCCTGCAGCTGGAGGAGGAGAGGAAGCGGGCACAGGAGGAGGCCGAGCGCCTAGAGGCTGACCGTATGGC
TGCACTGCGGGCTAAGGAGGAGCTGGAGAGACAGGCGGTGGATCAGATAAAGAGCCAGGAGCAGCTGGCTGCGGAGCTTGCAGAATACAC
TGCCAAGATTGCCCTCCTGGAAGAGGCGCGGAGGCGCAAGGAGGATGAAGTTGAAGAGTGGCAGCACAGGGCCAAAGAAGCCCAGGATGA
CCTGGTGAAGACCAAGGAGGAGCTGCACCTGGTGATGACAGCACCCCCGCCCCCACCACCCCCCGTGTACGAGCCGGTGAGCTACCATGT
CCAGGAGAGCTTGCAGGATGAGGGCGCAGAGCCCACGGGCTACAGCGCGGAGCTGTCTAGTGAGGGCATCCGGGATGACCGCAATGAGGA
GAAGCGCATCACTGAGGCAGAGAAGAACGAGCGTGTGCAGCGGCAGCTGCTGACGCTGAGCAGCGAGCTGTCCCAGGCCCGAGATGAGAA
TAAGAGGACCCACAATGACATCATCCACAACGAGAACATGAGGCAAGGCCGGGACAAGTACAAGACGCTGCGGCAGATCCGGCAGGGCAA

>44787_44787_9_LIN9-EZR_LIN9_chr1_226485419_ENST00000481685_EZR_chr6_159210403_ENST00000392177_length(amino acids)=619AA_BP=69
MHRGGQPLKKRRGSFKMAELDQLPDESSSAKALVSLKEGSLSNTWNEKYSSLQKTPVWKGRNTSSAVEMINVRVTTMDAELEFAIQPNTT
GKQLFDQVSAQEVRKENPLQFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYCPPETAVLLGSYAVQAKFGDYNKEVHKSGYL
SSERLIPQRVMDQHKLTRDQWEDRIQVWHAEHRGMLKDNAMLEYLKIAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPK
IGFPWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILQLCMGNHELYMRRRKPDTIEVQQMKAQAREEKHQKQLERQQLETEK
KRRETVEREKEQMMREKEELMLRLQDYEEKTKKAERELSEQIQRALQLEEERKRAQEEAERLEADRMAALRAKEELERQAVDQIKSQEQL
AAELAEYTAKIALLEEARRRKEDEVEEWQHRAKEAQDDLVKTKEELHLVMTAPPPPPPPVYEPVSYHVQESLQDEGAEPTGYSAELSSEG

--------------------------------------------------------------

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Fusion Gene PPI Analysis for LIN9-EZR

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Still interaction with
Tgene	EZR	chr1:226485419	chr6:159210403	ENST00000337147		0	13	244_586	4.0	587.0	SCYL3
Tgene	EZR	chr1:226485419	chr6:159210403	ENST00000367075		1	14	244_586	4.0	587.0	SCYL3

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for LIN9-EZR

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for LIN9-EZR

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source