FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:LINC00893-IKBKE (FusionGDB2 ID:45067)

Fusion Gene Summary for LINC00893-IKBKE

check button Fusion gene summary
Fusion gene informationFusion gene name: LINC00893-IKBKE
Fusion gene ID: 45067
HgeneTgene
Gene symbol

LINC00893

IKBKE

Gene ID

100131434

9641

Gene namelong intergenic non-protein coding RNA 893inhibitor of nuclear factor kappa B kinase subunit epsilon
Synonyms-IKK-E|IKK-i|IKKE|IKKI
Cytomap

Xq28

1q32.1

Type of genencRNAprotein-coding
Descriptiongene Winhibitor of nuclear factor kappa-B kinase subunit epsilonI-kappa-B kinase epsilonIKK-epsilonIKK-related kinase epsiloninducible I kappa-B kinaseinducible IkappaB kinaseinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
Modification date2020031320200313
UniProtAcc.

Q14164

Ensembl transtripts involved in fusion geneENST00000447209, ENST00000451969, 
ENST00000608616, ENST00000609161, 
ENST00000412882, ENST00000430173, 
ENST00000431025, ENST00000431214, 
ENST00000436708, ENST00000437981, 
ENST00000541582, ENST00000596412, 
ENST00000608342, ENST00000608355, 
ENST00000609314, ENST00000609369, 
ENST00000609651, 		ENST00000367120, 
ENST00000537984, ENST00000463979, 
Fusion gene scores* DoF score2 X 2 X 2=83 X 3 X 3=27
# samples 23
** MAII scorelog2(2/8*10)=1.32192809488736log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: LINC00893 [Title/Abstract] AND IKBKE [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointLINC00893(148615736)-IKBKE(206666356), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneIKBKE

GO:0006468

protein phosphorylation

10882136|20188669|24882218


check buttonFusion gene breakpoints across LINC00893 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across IKBKE (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-EQ-A4SO-01ALINC00893chrX

148615736

-IKBKEchr1

206666356

+


Top

Fusion Gene ORF analysis for LINC00893-IKBKE

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000447209ENST00000367120LINC00893chrX

148615736

-IKBKEchr1

206666356

+
5UTR-3CDSENST00000447209ENST00000537984LINC00893chrX

148615736

-IKBKEchr1

206666356

+
5UTR-3CDSENST00000451969ENST00000367120LINC00893chrX

148615736

-IKBKEchr1

206666356

+
5UTR-3CDSENST00000451969ENST00000537984LINC00893chrX

148615736

-IKBKEchr1

206666356

+
5UTR-3CDSENST00000608616ENST00000367120LINC00893chrX

148615736

-IKBKEchr1

206666356

+
5UTR-3CDSENST00000608616ENST00000537984LINC00893chrX

148615736

-IKBKEchr1

206666356

+
5UTR-3CDSENST00000609161ENST00000367120LINC00893chrX

148615736

-IKBKEchr1

206666356

+
5UTR-3CDSENST00000609161ENST00000537984LINC00893chrX

148615736

-IKBKEchr1

206666356

+
5UTR-intronENST00000447209ENST00000463979LINC00893chrX

148615736

-IKBKEchr1

206666356

+
5UTR-intronENST00000451969ENST00000463979LINC00893chrX

148615736

-IKBKEchr1

206666356

+
5UTR-intronENST00000608616ENST00000463979LINC00893chrX

148615736

-IKBKEchr1

206666356

+
5UTR-intronENST00000609161ENST00000463979LINC00893chrX

148615736

-IKBKEchr1

206666356

+
intron-3CDSENST00000412882ENST00000367120LINC00893chrX

148615736

-IKBKEchr1

206666356

+
intron-3CDSENST00000412882ENST00000537984LINC00893chrX

148615736

-IKBKEchr1

206666356

+
intron-3CDSENST00000430173ENST00000367120LINC00893chrX

148615736

-IKBKEchr1

206666356

+
intron-3CDSENST00000430173ENST00000537984LINC00893chrX

148615736

-IKBKEchr1

206666356

+
intron-3CDSENST00000431025ENST00000367120LINC00893chrX

148615736

-IKBKEchr1

206666356

+
intron-3CDSENST00000431025ENST00000537984LINC00893chrX

148615736

-IKBKEchr1

206666356

+
intron-3CDSENST00000431214ENST00000367120LINC00893chrX

148615736

-IKBKEchr1

206666356

+
intron-3CDSENST00000431214ENST00000537984LINC00893chrX

148615736

-IKBKEchr1

206666356

+
intron-3CDSENST00000436708ENST00000367120LINC00893chrX

148615736

-IKBKEchr1

206666356

+
intron-3CDSENST00000436708ENST00000537984LINC00893chrX

148615736

-IKBKEchr1

206666356

+
intron-3CDSENST00000437981ENST00000367120LINC00893chrX

148615736

-IKBKEchr1

206666356

+
intron-3CDSENST00000437981ENST00000537984LINC00893chrX

148615736

-IKBKEchr1

206666356

+
intron-3CDSENST00000541582ENST00000367120LINC00893chrX

148615736

-IKBKEchr1

206666356

+
intron-3CDSENST00000541582ENST00000537984LINC00893chrX

148615736

-IKBKEchr1

206666356

+
intron-3CDSENST00000596412ENST00000367120LINC00893chrX

148615736

-IKBKEchr1

206666356

+
intron-3CDSENST00000596412ENST00000537984LINC00893chrX

148615736

-IKBKEchr1

206666356

+
intron-3CDSENST00000608342ENST00000367120LINC00893chrX

148615736

-IKBKEchr1

206666356

+
intron-3CDSENST00000608342ENST00000537984LINC00893chrX

148615736

-IKBKEchr1

206666356

+
intron-3CDSENST00000608355ENST00000367120LINC00893chrX

148615736

-IKBKEchr1

206666356

+
intron-3CDSENST00000608355ENST00000537984LINC00893chrX

148615736

-IKBKEchr1

206666356

+
intron-3CDSENST00000609314ENST00000367120LINC00893chrX

148615736

-IKBKEchr1

206666356

+
intron-3CDSENST00000609314ENST00000537984LINC00893chrX

148615736

-IKBKEchr1

206666356

+
intron-3CDSENST00000609369ENST00000367120LINC00893chrX

148615736

-IKBKEchr1

206666356

+
intron-3CDSENST00000609369ENST00000537984LINC00893chrX

148615736

-IKBKEchr1

206666356

+
intron-3CDSENST00000609651ENST00000367120LINC00893chrX

148615736

-IKBKEchr1

206666356

+
intron-3CDSENST00000609651ENST00000537984LINC00893chrX

148615736

-IKBKEchr1

206666356

+
intron-intronENST00000412882ENST00000463979LINC00893chrX

148615736

-IKBKEchr1

206666356

+
intron-intronENST00000430173ENST00000463979LINC00893chrX

148615736

-IKBKEchr1

206666356

+
intron-intronENST00000431025ENST00000463979LINC00893chrX

148615736

-IKBKEchr1

206666356

+
intron-intronENST00000431214ENST00000463979LINC00893chrX

148615736

-IKBKEchr1

206666356

+
intron-intronENST00000436708ENST00000463979LINC00893chrX

148615736

-IKBKEchr1

206666356

+
intron-intronENST00000437981ENST00000463979LINC00893chrX

148615736

-IKBKEchr1

206666356

+
intron-intronENST00000541582ENST00000463979LINC00893chrX

148615736

-IKBKEchr1

206666356

+
intron-intronENST00000596412ENST00000463979LINC00893chrX

148615736

-IKBKEchr1

206666356

+
intron-intronENST00000608342ENST00000463979LINC00893chrX

148615736

-IKBKEchr1

206666356

+
intron-intronENST00000608355ENST00000463979LINC00893chrX

148615736

-IKBKEchr1

206666356

+
intron-intronENST00000609314ENST00000463979LINC00893chrX

148615736

-IKBKEchr1

206666356

+
intron-intronENST00000609369ENST00000463979LINC00893chrX

148615736

-IKBKEchr1

206666356

+
intron-intronENST00000609651ENST00000463979LINC00893chrX

148615736

-IKBKEchr1

206666356

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

Top

Fusion Genomic Features for LINC00893-IKBKE


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
LINC00893chrX148615735-IKBKEchr1206666355+0.0085634660.99143654
LINC00893chrX148615735-IKBKEchr1206666355+0.0085634660.99143654

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for LINC00893-IKBKE


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:148615736/:206666356)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.IKBKE

Q14164

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Serine/threonine kinase that plays an essential role in regulating inflammatory responses to viral infection, through the activation of the type I IFN, NF-kappa-B and STAT signaling. Also involved in TNFA and inflammatory cytokines, like Interleukin-1, signaling. Following activation of viral RNA sensors, such as RIG-I-like receptors, associates with DDX3X and phosphorylates interferon regulatory factors (IRFs), IRF3 and IRF7, as well as DDX3X. This activity allows subsequent homodimerization and nuclear translocation of the IRF3 leading to transcriptional activation of pro-inflammatory and antiviral genes including IFNB. In order to establish such an antiviral state, IKBKE forms several different complexes whose composition depends on the type of cell and cellular stimuli. Thus, several scaffolding molecules including IPS1/MAVS, TANK, AZI2/NAP1 or TBKBP1/SINTBAD can be recruited to the IKBKE-containing-complexes. Activated by polyubiquitination in response to TNFA and interleukin-1, regulates the NF-kappa-B signaling pathway through, at least, the phosphorylation of CYLD. Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. In addition, is also required for the induction of a subset of ISGs which displays antiviral activity, may be through the phosphorylation of STAT1 at 'Ser-708'. Phosphorylation of STAT1 at 'Ser-708' seems also to promote the assembly and DNA binding of ISGF3 (STAT1:STAT2:IRF9) complexes compared to GAF (STAT1:STAT1) complexes, in this way regulating the balance between type I and type II IFN responses. Protects cells against DNA damage-induced cell death. Also plays an important role in energy balance regulation by sustaining a state of chronic, low-grade inflammation in obesity, wich leads to a negative impact on insulin sensitivity. Phosphorylates AKT1. {ECO:0000269|PubMed:17568778, ECO:0000269|PubMed:18583960, ECO:0000269|PubMed:19153231, ECO:0000269|PubMed:20188669, ECO:0000269|PubMed:21138416, ECO:0000269|PubMed:21464307, ECO:0000269|PubMed:22532683, ECO:0000269|PubMed:23453969, ECO:0000269|PubMed:23478265}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

Fusion Gene Sequence for LINC00893-IKBKE


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

Top

Fusion Gene PPI Analysis for LINC00893-IKBKE


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for LINC00893-IKBKE


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for LINC00893-IKBKE


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource