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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:LINC01088-SNCA (FusionGDB2 ID:45161)

Fusion Gene Summary for LINC01088-SNCA

Fusion gene summary

Fusion gene information	Fusion gene name: LINC01088-SNCA
	Fusion gene ID: 45161
		Hgene	Tgene
	Gene symbol	LINC01088	SNCA
	Gene ID	100505875	6622
	Gene name	long intergenic non-protein coding RNA 1088	synuclein alpha
	Synonyms	-	NACP\|PARK1\|PARK4\|PD1
	Cytomap	4q21.21	4q22.1
	Type of gene	ncRNA	protein-coding
	Description	-	alpha-synucleinI+/--synucleinnon A-beta component of AD amyloidsynuclein alpha-140synuclein, alpha (non A4 component of amyloid precursor)truncated alpha synuclein
	Modification date	20200313	20200329
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000509088, ENST00000510667, ENST00000513153, ENST00000437737, ENST00000505149, ENST00000507476, ENST00000507761, ENST00000511241, ENST00000511895, ENST00000512130, ENST00000515597,	ENST00000336904, ENST00000345009, ENST00000394986, ENST00000394989, ENST00000394991, ENST00000420646, ENST00000502987, ENST00000505199, ENST00000506244, ENST00000508895,
Fusion gene scores	* DoF score	2 X 2 X 2=8	2 X 2 X 2=8
	# samples	2	2
	** MAII score	log2(2/8*10)=1.32192809488736	log2(2/8*10)=1.32192809488736
Context	PubMed: LINC01088 [Title/Abstract] AND SNCA [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	LINC01088(80007416)-SNCA(90650428), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	SNCA	GO:0001921	positive regulation of receptor recycling	18980610
Tgene	SNCA	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	21050448
Tgene	SNCA	GO:0010040	response to iron(II) ion	11850416
Tgene	SNCA	GO:0010517	regulation of phospholipase activity	15641770
Tgene	SNCA	GO:0010642	negative regulation of platelet-derived growth factor receptor signaling pathway	12239163
Tgene	SNCA	GO:0016079	synaptic vesicle exocytosis	28288128
Tgene	SNCA	GO:0031115	negative regulation of microtubule polymerization	21127069
Tgene	SNCA	GO:0031623	receptor internalization	18980610
Tgene	SNCA	GO:0031648	protein destabilization	21320589
Tgene	SNCA	GO:0032026	response to magnesium ion	11850416
Tgene	SNCA	GO:0032410	negative regulation of transporter activity	16882008
Tgene	SNCA	GO:0032496	response to lipopolysaccharide	12406186
Tgene	SNCA	GO:0032769	negative regulation of monooxygenase activity	11943812
Tgene	SNCA	GO:0034341	response to interferon-gamma	19157893
Tgene	SNCA	GO:0035067	negative regulation of histone acetylation	16959795
Tgene	SNCA	GO:0035493	SNARE complex assembly	20798282
Tgene	SNCA	GO:0035543	positive regulation of SNARE complex assembly	20798282
Tgene	SNCA	GO:0045807	positive regulation of endocytosis	18980610
Tgene	SNCA	GO:0050729	positive regulation of inflammatory response	25533483
Tgene	SNCA	GO:0051262	protein tetramerization	21841800
Tgene	SNCA	GO:0051281	positive regulation of release of sequestered calcium ion into cytosol	15641770
Tgene	SNCA	GO:0051585	negative regulation of dopamine uptake involved in synaptic transmission	12958153
Tgene	SNCA	GO:0051612	negative regulation of serotonin uptake	16882008
Tgene	SNCA	GO:0051622	negative regulation of norepinephrine uptake	17156375
Tgene	SNCA	GO:0055074	calcium ion homeostasis	12239163
Tgene	SNCA	GO:0055114	oxidation-reduction process	21320589
Tgene	SNCA	GO:0060732	positive regulation of inositol phosphate biosynthetic process	15641770
Tgene	SNCA	GO:0070495	negative regulation of thrombin-activated receptor signaling pathway	12239163
Tgene	SNCA	GO:0070555	response to interleukin-1	12406186
Tgene	SNCA	GO:0071280	cellular response to copper ion	21320589
Tgene	SNCA	GO:0071902	positive regulation of protein serine/threonine kinase activity	21127069
Tgene	SNCA	GO:1901215	negative regulation of neuron death	15863497
Tgene	SNCA	GO:1901216	positive regulation of neuron death	25533483
Tgene	SNCA	GO:1903284	positive regulation of glutathione peroxidase activity	23507046
Tgene	SNCA	GO:1903285	positive regulation of hydrogen peroxide catabolic process	23507046

Fusion gene breakpoints across LINC01088 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across SNCA (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	SARC	TCGA-X9-A971-01A	LINC01088	chr4	80007416	+	SNCA	chr4	90650428	-

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Fusion Gene ORF analysis for LINC01088-SNCA

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
3UTR-intron	ENST00000509088	ENST00000336904	LINC01088	chr4	80007416	+	SNCA	chr4	90650428	-
3UTR-intron	ENST00000509088	ENST00000345009	LINC01088	chr4	80007416	+	SNCA	chr4	90650428	-
3UTR-intron	ENST00000509088	ENST00000394986	LINC01088	chr4	80007416	+	SNCA	chr4	90650428	-
3UTR-intron	ENST00000509088	ENST00000394989	LINC01088	chr4	80007416	+	SNCA	chr4	90650428	-
3UTR-intron	ENST00000509088	ENST00000394991	LINC01088	chr4	80007416	+	SNCA	chr4	90650428	-
3UTR-intron	ENST00000509088	ENST00000420646	LINC01088	chr4	80007416	+	SNCA	chr4	90650428	-
3UTR-intron	ENST00000509088	ENST00000502987	LINC01088	chr4	80007416	+	SNCA	chr4	90650428	-
3UTR-intron	ENST00000509088	ENST00000505199	LINC01088	chr4	80007416	+	SNCA	chr4	90650428	-
3UTR-intron	ENST00000509088	ENST00000506244	LINC01088	chr4	80007416	+	SNCA	chr4	90650428	-
3UTR-intron	ENST00000509088	ENST00000508895	LINC01088	chr4	80007416	+	SNCA	chr4	90650428	-
3UTR-intron	ENST00000510667	ENST00000336904	LINC01088	chr4	80007416	+	SNCA	chr4	90650428	-
3UTR-intron	ENST00000510667	ENST00000345009	LINC01088	chr4	80007416	+	SNCA	chr4	90650428	-
3UTR-intron	ENST00000510667	ENST00000394986	LINC01088	chr4	80007416	+	SNCA	chr4	90650428	-
3UTR-intron	ENST00000510667	ENST00000394989	LINC01088	chr4	80007416	+	SNCA	chr4	90650428	-
3UTR-intron	ENST00000510667	ENST00000394991	LINC01088	chr4	80007416	+	SNCA	chr4	90650428	-
3UTR-intron	ENST00000510667	ENST00000420646	LINC01088	chr4	80007416	+	SNCA	chr4	90650428	-
3UTR-intron	ENST00000510667	ENST00000502987	LINC01088	chr4	80007416	+	SNCA	chr4	90650428	-
3UTR-intron	ENST00000510667	ENST00000505199	LINC01088	chr4	80007416	+	SNCA	chr4	90650428	-
3UTR-intron	ENST00000510667	ENST00000506244	LINC01088	chr4	80007416	+	SNCA	chr4	90650428	-
3UTR-intron	ENST00000510667	ENST00000508895	LINC01088	chr4	80007416	+	SNCA	chr4	90650428	-
3UTR-intron	ENST00000513153	ENST00000336904	LINC01088	chr4	80007416	+	SNCA	chr4	90650428	-
3UTR-intron	ENST00000513153	ENST00000345009	LINC01088	chr4	80007416	+	SNCA	chr4	90650428	-
3UTR-intron	ENST00000513153	ENST00000394986	LINC01088	chr4	80007416	+	SNCA	chr4	90650428	-
3UTR-intron	ENST00000513153	ENST00000394989	LINC01088	chr4	80007416	+	SNCA	chr4	90650428	-
3UTR-intron	ENST00000513153	ENST00000394991	LINC01088	chr4	80007416	+	SNCA	chr4	90650428	-
3UTR-intron	ENST00000513153	ENST00000420646	LINC01088	chr4	80007416	+	SNCA	chr4	90650428	-
3UTR-intron	ENST00000513153	ENST00000502987	LINC01088	chr4	80007416	+	SNCA	chr4	90650428	-
3UTR-intron	ENST00000513153	ENST00000505199	LINC01088	chr4	80007416	+	SNCA	chr4	90650428	-
3UTR-intron	ENST00000513153	ENST00000506244	LINC01088	chr4	80007416	+	SNCA	chr4	90650428	-
3UTR-intron	ENST00000513153	ENST00000508895	LINC01088	chr4	80007416	+	SNCA	chr4	90650428	-
intron-intron	ENST00000437737	ENST00000336904	LINC01088	chr4	80007416	+	SNCA	chr4	90650428	-
intron-intron	ENST00000437737	ENST00000345009	LINC01088	chr4	80007416	+	SNCA	chr4	90650428	-
intron-intron	ENST00000437737	ENST00000394986	LINC01088	chr4	80007416	+	SNCA	chr4	90650428	-
intron-intron	ENST00000437737	ENST00000394989	LINC01088	chr4	80007416	+	SNCA	chr4	90650428	-
intron-intron	ENST00000437737	ENST00000394991	LINC01088	chr4	80007416	+	SNCA	chr4	90650428	-
intron-intron	ENST00000437737	ENST00000420646	LINC01088	chr4	80007416	+	SNCA	chr4	90650428	-
intron-intron	ENST00000437737	ENST00000502987	LINC01088	chr4	80007416	+	SNCA	chr4	90650428	-
intron-intron	ENST00000437737	ENST00000505199	LINC01088	chr4	80007416	+	SNCA	chr4	90650428	-
intron-intron	ENST00000437737	ENST00000506244	LINC01088	chr4	80007416	+	SNCA	chr4	90650428	-
intron-intron	ENST00000437737	ENST00000508895	LINC01088	chr4	80007416	+	SNCA	chr4	90650428	-
intron-intron	ENST00000505149	ENST00000336904	LINC01088	chr4	80007416	+	SNCA	chr4	90650428	-
intron-intron	ENST00000505149	ENST00000345009	LINC01088	chr4	80007416	+	SNCA	chr4	90650428	-
intron-intron	ENST00000505149	ENST00000394986	LINC01088	chr4	80007416	+	SNCA	chr4	90650428	-
intron-intron	ENST00000505149	ENST00000394989	LINC01088	chr4	80007416	+	SNCA	chr4	90650428	-
intron-intron	ENST00000505149	ENST00000394991	LINC01088	chr4	80007416	+	SNCA	chr4	90650428	-
intron-intron	ENST00000505149	ENST00000420646	LINC01088	chr4	80007416	+	SNCA	chr4	90650428	-
intron-intron	ENST00000505149	ENST00000502987	LINC01088	chr4	80007416	+	SNCA	chr4	90650428	-
intron-intron	ENST00000505149	ENST00000505199	LINC01088	chr4	80007416	+	SNCA	chr4	90650428	-
intron-intron	ENST00000505149	ENST00000506244	LINC01088	chr4	80007416	+	SNCA	chr4	90650428	-
intron-intron	ENST00000505149	ENST00000508895	LINC01088	chr4	80007416	+	SNCA	chr4	90650428	-
intron-intron	ENST00000507476	ENST00000336904	LINC01088	chr4	80007416	+	SNCA	chr4	90650428	-
intron-intron	ENST00000507476	ENST00000345009	LINC01088	chr4	80007416	+	SNCA	chr4	90650428	-
intron-intron	ENST00000507476	ENST00000394986	LINC01088	chr4	80007416	+	SNCA	chr4	90650428	-
intron-intron	ENST00000507476	ENST00000394989	LINC01088	chr4	80007416	+	SNCA	chr4	90650428	-
intron-intron	ENST00000507476	ENST00000394991	LINC01088	chr4	80007416	+	SNCA	chr4	90650428	-
intron-intron	ENST00000507476	ENST00000420646	LINC01088	chr4	80007416	+	SNCA	chr4	90650428	-
intron-intron	ENST00000507476	ENST00000502987	LINC01088	chr4	80007416	+	SNCA	chr4	90650428	-
intron-intron	ENST00000507476	ENST00000505199	LINC01088	chr4	80007416	+	SNCA	chr4	90650428	-
intron-intron	ENST00000507476	ENST00000506244	LINC01088	chr4	80007416	+	SNCA	chr4	90650428	-
intron-intron	ENST00000507476	ENST00000508895	LINC01088	chr4	80007416	+	SNCA	chr4	90650428	-
intron-intron	ENST00000507761	ENST00000336904	LINC01088	chr4	80007416	+	SNCA	chr4	90650428	-
intron-intron	ENST00000507761	ENST00000345009	LINC01088	chr4	80007416	+	SNCA	chr4	90650428	-
intron-intron	ENST00000507761	ENST00000394986	LINC01088	chr4	80007416	+	SNCA	chr4	90650428	-
intron-intron	ENST00000507761	ENST00000394989	LINC01088	chr4	80007416	+	SNCA	chr4	90650428	-
intron-intron	ENST00000507761	ENST00000394991	LINC01088	chr4	80007416	+	SNCA	chr4	90650428	-
intron-intron	ENST00000507761	ENST00000420646	LINC01088	chr4	80007416	+	SNCA	chr4	90650428	-
intron-intron	ENST00000507761	ENST00000502987	LINC01088	chr4	80007416	+	SNCA	chr4	90650428	-
intron-intron	ENST00000507761	ENST00000505199	LINC01088	chr4	80007416	+	SNCA	chr4	90650428	-
intron-intron	ENST00000507761	ENST00000506244	LINC01088	chr4	80007416	+	SNCA	chr4	90650428	-
intron-intron	ENST00000507761	ENST00000508895	LINC01088	chr4	80007416	+	SNCA	chr4	90650428	-
intron-intron	ENST00000511241	ENST00000336904	LINC01088	chr4	80007416	+	SNCA	chr4	90650428	-
intron-intron	ENST00000511241	ENST00000345009	LINC01088	chr4	80007416	+	SNCA	chr4	90650428	-
intron-intron	ENST00000511241	ENST00000394986	LINC01088	chr4	80007416	+	SNCA	chr4	90650428	-
intron-intron	ENST00000511241	ENST00000394989	LINC01088	chr4	80007416	+	SNCA	chr4	90650428	-
intron-intron	ENST00000511241	ENST00000394991	LINC01088	chr4	80007416	+	SNCA	chr4	90650428	-
intron-intron	ENST00000511241	ENST00000420646	LINC01088	chr4	80007416	+	SNCA	chr4	90650428	-
intron-intron	ENST00000511241	ENST00000502987	LINC01088	chr4	80007416	+	SNCA	chr4	90650428	-
intron-intron	ENST00000511241	ENST00000505199	LINC01088	chr4	80007416	+	SNCA	chr4	90650428	-
intron-intron	ENST00000511241	ENST00000506244	LINC01088	chr4	80007416	+	SNCA	chr4	90650428	-
intron-intron	ENST00000511241	ENST00000508895	LINC01088	chr4	80007416	+	SNCA	chr4	90650428	-
intron-intron	ENST00000511895	ENST00000336904	LINC01088	chr4	80007416	+	SNCA	chr4	90650428	-
intron-intron	ENST00000511895	ENST00000345009	LINC01088	chr4	80007416	+	SNCA	chr4	90650428	-
intron-intron	ENST00000511895	ENST00000394986	LINC01088	chr4	80007416	+	SNCA	chr4	90650428	-
intron-intron	ENST00000511895	ENST00000394989	LINC01088	chr4	80007416	+	SNCA	chr4	90650428	-
intron-intron	ENST00000511895	ENST00000394991	LINC01088	chr4	80007416	+	SNCA	chr4	90650428	-
intron-intron	ENST00000511895	ENST00000420646	LINC01088	chr4	80007416	+	SNCA	chr4	90650428	-
intron-intron	ENST00000511895	ENST00000502987	LINC01088	chr4	80007416	+	SNCA	chr4	90650428	-
intron-intron	ENST00000511895	ENST00000505199	LINC01088	chr4	80007416	+	SNCA	chr4	90650428	-
intron-intron	ENST00000511895	ENST00000506244	LINC01088	chr4	80007416	+	SNCA	chr4	90650428	-
intron-intron	ENST00000511895	ENST00000508895	LINC01088	chr4	80007416	+	SNCA	chr4	90650428	-
intron-intron	ENST00000512130	ENST00000336904	LINC01088	chr4	80007416	+	SNCA	chr4	90650428	-
intron-intron	ENST00000512130	ENST00000345009	LINC01088	chr4	80007416	+	SNCA	chr4	90650428	-
intron-intron	ENST00000512130	ENST00000394986	LINC01088	chr4	80007416	+	SNCA	chr4	90650428	-
intron-intron	ENST00000512130	ENST00000394989	LINC01088	chr4	80007416	+	SNCA	chr4	90650428	-
intron-intron	ENST00000512130	ENST00000394991	LINC01088	chr4	80007416	+	SNCA	chr4	90650428	-
intron-intron	ENST00000512130	ENST00000420646	LINC01088	chr4	80007416	+	SNCA	chr4	90650428	-
intron-intron	ENST00000512130	ENST00000502987	LINC01088	chr4	80007416	+	SNCA	chr4	90650428	-
intron-intron	ENST00000512130	ENST00000505199	LINC01088	chr4	80007416	+	SNCA	chr4	90650428	-
intron-intron	ENST00000512130	ENST00000506244	LINC01088	chr4	80007416	+	SNCA	chr4	90650428	-
intron-intron	ENST00000512130	ENST00000508895	LINC01088	chr4	80007416	+	SNCA	chr4	90650428	-
intron-intron	ENST00000515597	ENST00000336904	LINC01088	chr4	80007416	+	SNCA	chr4	90650428	-
intron-intron	ENST00000515597	ENST00000345009	LINC01088	chr4	80007416	+	SNCA	chr4	90650428	-
intron-intron	ENST00000515597	ENST00000394986	LINC01088	chr4	80007416	+	SNCA	chr4	90650428	-
intron-intron	ENST00000515597	ENST00000394989	LINC01088	chr4	80007416	+	SNCA	chr4	90650428	-
intron-intron	ENST00000515597	ENST00000394991	LINC01088	chr4	80007416	+	SNCA	chr4	90650428	-
intron-intron	ENST00000515597	ENST00000420646	LINC01088	chr4	80007416	+	SNCA	chr4	90650428	-
intron-intron	ENST00000515597	ENST00000502987	LINC01088	chr4	80007416	+	SNCA	chr4	90650428	-
intron-intron	ENST00000515597	ENST00000505199	LINC01088	chr4	80007416	+	SNCA	chr4	90650428	-
intron-intron	ENST00000515597	ENST00000506244	LINC01088	chr4	80007416	+	SNCA	chr4	90650428	-
intron-intron	ENST00000515597	ENST00000508895	LINC01088	chr4	80007416	+	SNCA	chr4	90650428	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Genomic Features for LINC01088-SNCA

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for LINC01088-SNCA

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:80007416/:90650428)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for LINC01088-SNCA

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for LINC01088-SNCA

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for LINC01088-SNCA

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for LINC01088-SNCA

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source