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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ABI1-YME1L1 (FusionGDB2 ID:454)

Fusion Gene Summary for ABI1-YME1L1

check button Fusion gene summary
Fusion gene informationFusion gene name: ABI1-YME1L1
Fusion gene ID: 454
HgeneTgene
Gene symbol

ABI1

YME1L1

Gene ID

10006

10730

Gene nameabl interactor 1YME1 like 1 ATPase
SynonymsABI-1|ABLBP4|E3B1|NAP1BP|SSH3BP|SSH3BP1FTSH|MEG4|OPA11|PAMP|YME1L
Cytomap

10p12.1

10p12.1

Type of geneprotein-codingprotein-coding
Descriptionabl interactor 1Abelson interactor 1Abl-interactor protein 1 longabl-binding protein 4eps8 SH3 domain-binding proteininteractor protein AblBP4nap1 binding proteinspectrin SH3 domain-binding protein 1ATP-dependent zinc metalloprotease YME1L1ATP-dependent metalloprotease FtsH1 homologYME1-like protein 1meg-4presenilin-associated metalloprotease
Modification date2020032720200313
UniProtAcc

Q8IZP0

.
Ensembl transtripts involved in fusion geneENST00000346832, ENST00000355394, 
ENST00000359188, ENST00000376134, 
ENST00000376137, ENST00000376138, 
ENST00000376139, ENST00000376140, 
ENST00000376142, ENST00000376160, 
ENST00000376166, ENST00000376170, 
ENST00000490841, ENST00000536334, 
ENST00000473481, 		ENST00000463270, 
ENST00000477432, ENST00000326799, 
ENST00000375972, ENST00000376016, 
Fusion gene scores* DoF score15 X 10 X 8=12005 X 4 X 4=80
# samples 155
** MAII scorelog2(15/1200*10)=-3
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/80*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ABI1 [Title/Abstract] AND YME1L1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointABI1(27112067)-YME1L1(27409478), # samples:1
Anticipated loss of major functional domain due to fusion event.ABI1-YME1L1 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
ABI1-YME1L1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
ABI1-YME1L1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneABI1

GO:0018108

peptidyl-tyrosine phosphorylation

17101133

TgeneYME1L1

GO:0034214

protein hexamerization

27786171


check buttonFusion gene breakpoints across ABI1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across YME1L1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ADA016422ABI1chr10

27112067

-YME1L1chr10

27409478

-


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Fusion Gene ORF analysis for ABI1-YME1L1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000346832ENST00000463270ABI1chr10

27112067

-YME1L1chr10

27409478

-
5CDS-intronENST00000346832ENST00000477432ABI1chr10

27112067

-YME1L1chr10

27409478

-
5CDS-intronENST00000355394ENST00000463270ABI1chr10

27112067

-YME1L1chr10

27409478

-
5CDS-intronENST00000355394ENST00000477432ABI1chr10

27112067

-YME1L1chr10

27409478

-
5CDS-intronENST00000359188ENST00000463270ABI1chr10

27112067

-YME1L1chr10

27409478

-
5CDS-intronENST00000359188ENST00000477432ABI1chr10

27112067

-YME1L1chr10

27409478

-
5CDS-intronENST00000376134ENST00000463270ABI1chr10

27112067

-YME1L1chr10

27409478

-
5CDS-intronENST00000376134ENST00000477432ABI1chr10

27112067

-YME1L1chr10

27409478

-
5CDS-intronENST00000376137ENST00000463270ABI1chr10

27112067

-YME1L1chr10

27409478

-
5CDS-intronENST00000376137ENST00000477432ABI1chr10

27112067

-YME1L1chr10

27409478

-
5CDS-intronENST00000376138ENST00000463270ABI1chr10

27112067

-YME1L1chr10

27409478

-
5CDS-intronENST00000376138ENST00000477432ABI1chr10

27112067

-YME1L1chr10

27409478

-
5CDS-intronENST00000376139ENST00000463270ABI1chr10

27112067

-YME1L1chr10

27409478

-
5CDS-intronENST00000376139ENST00000477432ABI1chr10

27112067

-YME1L1chr10

27409478

-
5CDS-intronENST00000376140ENST00000463270ABI1chr10

27112067

-YME1L1chr10

27409478

-
5CDS-intronENST00000376140ENST00000477432ABI1chr10

27112067

-YME1L1chr10

27409478

-
5CDS-intronENST00000376142ENST00000463270ABI1chr10

27112067

-YME1L1chr10

27409478

-
5CDS-intronENST00000376142ENST00000477432ABI1chr10

27112067

-YME1L1chr10

27409478

-
5CDS-intronENST00000376160ENST00000463270ABI1chr10

27112067

-YME1L1chr10

27409478

-
5CDS-intronENST00000376160ENST00000477432ABI1chr10

27112067

-YME1L1chr10

27409478

-
5CDS-intronENST00000376166ENST00000463270ABI1chr10

27112067

-YME1L1chr10

27409478

-
5CDS-intronENST00000376166ENST00000477432ABI1chr10

27112067

-YME1L1chr10

27409478

-
5CDS-intronENST00000376170ENST00000463270ABI1chr10

27112067

-YME1L1chr10

27409478

-
5CDS-intronENST00000376170ENST00000477432ABI1chr10

27112067

-YME1L1chr10

27409478

-
5CDS-intronENST00000490841ENST00000463270ABI1chr10

27112067

-YME1L1chr10

27409478

-
5CDS-intronENST00000490841ENST00000477432ABI1chr10

27112067

-YME1L1chr10

27409478

-
5CDS-intronENST00000536334ENST00000463270ABI1chr10

27112067

-YME1L1chr10

27409478

-
5CDS-intronENST00000536334ENST00000477432ABI1chr10

27112067

-YME1L1chr10

27409478

-
5UTR-3CDSENST00000473481ENST00000326799ABI1chr10

27112067

-YME1L1chr10

27409478

-
5UTR-3CDSENST00000473481ENST00000375972ABI1chr10

27112067

-YME1L1chr10

27409478

-
5UTR-3CDSENST00000473481ENST00000376016ABI1chr10

27112067

-YME1L1chr10

27409478

-
5UTR-intronENST00000473481ENST00000463270ABI1chr10

27112067

-YME1L1chr10

27409478

-
5UTR-intronENST00000473481ENST00000477432ABI1chr10

27112067

-YME1L1chr10

27409478

-
Frame-shiftENST00000346832ENST00000326799ABI1chr10

27112067

-YME1L1chr10

27409478

-
Frame-shiftENST00000346832ENST00000375972ABI1chr10

27112067

-YME1L1chr10

27409478

-
Frame-shiftENST00000346832ENST00000376016ABI1chr10

27112067

-YME1L1chr10

27409478

-
Frame-shiftENST00000355394ENST00000326799ABI1chr10

27112067

-YME1L1chr10

27409478

-
Frame-shiftENST00000355394ENST00000375972ABI1chr10

27112067

-YME1L1chr10

27409478

-
Frame-shiftENST00000355394ENST00000376016ABI1chr10

27112067

-YME1L1chr10

27409478

-
Frame-shiftENST00000359188ENST00000326799ABI1chr10

27112067

-YME1L1chr10

27409478

-
Frame-shiftENST00000359188ENST00000375972ABI1chr10

27112067

-YME1L1chr10

27409478

-
Frame-shiftENST00000359188ENST00000376016ABI1chr10

27112067

-YME1L1chr10

27409478

-
Frame-shiftENST00000376134ENST00000326799ABI1chr10

27112067

-YME1L1chr10

27409478

-
Frame-shiftENST00000376134ENST00000375972ABI1chr10

27112067

-YME1L1chr10

27409478

-
Frame-shiftENST00000376134ENST00000376016ABI1chr10

27112067

-YME1L1chr10

27409478

-
Frame-shiftENST00000376137ENST00000326799ABI1chr10

27112067

-YME1L1chr10

27409478

-
Frame-shiftENST00000376137ENST00000375972ABI1chr10

27112067

-YME1L1chr10

27409478

-
Frame-shiftENST00000376137ENST00000376016ABI1chr10

27112067

-YME1L1chr10

27409478

-
Frame-shiftENST00000376138ENST00000326799ABI1chr10

27112067

-YME1L1chr10

27409478

-
Frame-shiftENST00000376138ENST00000375972ABI1chr10

27112067

-YME1L1chr10

27409478

-
Frame-shiftENST00000376138ENST00000376016ABI1chr10

27112067

-YME1L1chr10

27409478

-
Frame-shiftENST00000376139ENST00000326799ABI1chr10

27112067

-YME1L1chr10

27409478

-
Frame-shiftENST00000376139ENST00000375972ABI1chr10

27112067

-YME1L1chr10

27409478

-
Frame-shiftENST00000376139ENST00000376016ABI1chr10

27112067

-YME1L1chr10

27409478

-
Frame-shiftENST00000376140ENST00000326799ABI1chr10

27112067

-YME1L1chr10

27409478

-
Frame-shiftENST00000376140ENST00000375972ABI1chr10

27112067

-YME1L1chr10

27409478

-
Frame-shiftENST00000376140ENST00000376016ABI1chr10

27112067

-YME1L1chr10

27409478

-
Frame-shiftENST00000376142ENST00000326799ABI1chr10

27112067

-YME1L1chr10

27409478

-
Frame-shiftENST00000376142ENST00000375972ABI1chr10

27112067

-YME1L1chr10

27409478

-
Frame-shiftENST00000376142ENST00000376016ABI1chr10

27112067

-YME1L1chr10

27409478

-
Frame-shiftENST00000376160ENST00000326799ABI1chr10

27112067

-YME1L1chr10

27409478

-
Frame-shiftENST00000376160ENST00000375972ABI1chr10

27112067

-YME1L1chr10

27409478

-
Frame-shiftENST00000376160ENST00000376016ABI1chr10

27112067

-YME1L1chr10

27409478

-
Frame-shiftENST00000376166ENST00000326799ABI1chr10

27112067

-YME1L1chr10

27409478

-
Frame-shiftENST00000376166ENST00000375972ABI1chr10

27112067

-YME1L1chr10

27409478

-
Frame-shiftENST00000376166ENST00000376016ABI1chr10

27112067

-YME1L1chr10

27409478

-
Frame-shiftENST00000376170ENST00000326799ABI1chr10

27112067

-YME1L1chr10

27409478

-
Frame-shiftENST00000376170ENST00000375972ABI1chr10

27112067

-YME1L1chr10

27409478

-
Frame-shiftENST00000376170ENST00000376016ABI1chr10

27112067

-YME1L1chr10

27409478

-
Frame-shiftENST00000490841ENST00000326799ABI1chr10

27112067

-YME1L1chr10

27409478

-
Frame-shiftENST00000490841ENST00000375972ABI1chr10

27112067

-YME1L1chr10

27409478

-
Frame-shiftENST00000490841ENST00000376016ABI1chr10

27112067

-YME1L1chr10

27409478

-
Frame-shiftENST00000536334ENST00000326799ABI1chr10

27112067

-YME1L1chr10

27409478

-
Frame-shiftENST00000536334ENST00000375972ABI1chr10

27112067

-YME1L1chr10

27409478

-
Frame-shiftENST00000536334ENST00000376016ABI1chr10

27112067

-YME1L1chr10

27409478

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for ABI1-YME1L1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ABI1-YME1L1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:27112067/:27409478)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ABI1

Q8IZP0

.
FUNCTION: May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. May play a role in regulation of EGF-induced Erk pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1/c-Abl-mediated phosphorylation of ENAH. Recruits WASF1 to lamellipodia and there seems to regulate WASF1 protein level. In brain, seems to regulate the dendritic outgrowth and branching as well as to determine the shape and number of synaptic contacts of developing neurons. {ECO:0000269|PubMed:11003655, ECO:0000269|PubMed:18328268}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for ABI1-YME1L1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for ABI1-YME1L1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ABI1-YME1L1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ABI1-YME1L1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource