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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:LIPF-C3orf20 (FusionGDB2 ID:45639)

Fusion Gene Summary for LIPF-C3orf20

Fusion gene summary

Fusion gene information	Fusion gene name: LIPF-C3orf20
	Fusion gene ID: 45639
		Hgene	Tgene
	Gene symbol	LIPF	C3orf20
	Gene ID	8513	84077
	Gene name	lipase F, gastric type	chromosome 3 open reading frame 20
	Synonyms	GL\|HGL\|HLAL	-
	Cytomap	10q23.31	3p25.1
	Type of gene	protein-coding	protein-coding
	Description	gastric triacylglycerol lipasegastric lipaselipase, gastric	uncharacterized protein C3orf20
	Modification date	20200313	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000238983, ENST00000394375, ENST00000355843, ENST00000608620,	ENST00000412910, ENST00000435614, ENST00000495387, ENST00000253697,
Fusion gene scores	* DoF score	14 X 28 X 4=1568	4 X 4 X 3=48
	# samples	16	4
	** MAII score	log2(16/1568*10)=-3.29278174922785 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: LIPF [Title/Abstract] AND C3orf20 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	LIPF(90428394)-C3orf20(14724311), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across LIPF (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across C3orf20 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	Non-Cancer	TCGA-CG-5721-11A	LIPF	chr10	90428394	+	C3orf20	chr3	14724311	+

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Fusion Gene ORF analysis for LIPF-C3orf20

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000238983	ENST00000412910	LIPF	chr10	90428394	+	C3orf20	chr3	14724311	+
5CDS-intron	ENST00000238983	ENST00000435614	LIPF	chr10	90428394	+	C3orf20	chr3	14724311	+
5CDS-intron	ENST00000238983	ENST00000495387	LIPF	chr10	90428394	+	C3orf20	chr3	14724311	+
5CDS-intron	ENST00000394375	ENST00000412910	LIPF	chr10	90428394	+	C3orf20	chr3	14724311	+
5CDS-intron	ENST00000394375	ENST00000435614	LIPF	chr10	90428394	+	C3orf20	chr3	14724311	+
5CDS-intron	ENST00000394375	ENST00000495387	LIPF	chr10	90428394	+	C3orf20	chr3	14724311	+
In-frame	ENST00000238983	ENST00000253697	LIPF	chr10	90428394	+	C3orf20	chr3	14724311	+
In-frame	ENST00000394375	ENST00000253697	LIPF	chr10	90428394	+	C3orf20	chr3	14724311	+
intron-3CDS	ENST00000355843	ENST00000253697	LIPF	chr10	90428394	+	C3orf20	chr3	14724311	+
intron-3CDS	ENST00000608620	ENST00000253697	LIPF	chr10	90428394	+	C3orf20	chr3	14724311	+
intron-intron	ENST00000355843	ENST00000412910	LIPF	chr10	90428394	+	C3orf20	chr3	14724311	+
intron-intron	ENST00000355843	ENST00000435614	LIPF	chr10	90428394	+	C3orf20	chr3	14724311	+
intron-intron	ENST00000355843	ENST00000495387	LIPF	chr10	90428394	+	C3orf20	chr3	14724311	+
intron-intron	ENST00000608620	ENST00000412910	LIPF	chr10	90428394	+	C3orf20	chr3	14724311	+
intron-intron	ENST00000608620	ENST00000435614	LIPF	chr10	90428394	+	C3orf20	chr3	14724311	+
intron-intron	ENST00000608620	ENST00000495387	LIPF	chr10	90428394	+	C3orf20	chr3	14724311	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000394375

LIPF

chr10

90428394

ENST00000253697

C3orf20

chr3

14724311

3268

485

367

3108

913

ENST00000238983

LIPF

chr10

90428394

ENST00000253697

C3orf20

chr3

14724311

3171

388

270

3011

913

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000394375	ENST00000253697	LIPF	chr10	90428394	+	C3orf20	chr3	14724311	+	0.008723961	0.991276
ENST00000238983	ENST00000253697	LIPF	chr10	90428394	+	C3orf20	chr3	14724311	+	0.008983798	0.99101615

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Fusion Genomic Features for LIPF-C3orf20

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for LIPF-C3orf20

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:90428394/chr3:14724311)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

C3orf20

chr10:90428394

chr3:14724311

ENST00000253697

575_578

905.0

Compositional bias

Note=Poly-Glu

Tgene

C3orf20

chr10:90428394

chr3:14724311

ENST00000253697

857_860

905.0

Compositional bias

Note=Poly-Ser

Tgene

C3orf20

chr10:90428394

chr3:14724311

ENST00000253697

94_105

905.0

Compositional bias

Note=Poly-Pro

Tgene

C3orf20

chr10:90428394

chr3:14724311

ENST00000412910

575_578

783.0

Compositional bias

Note=Poly-Glu

Tgene

C3orf20

chr10:90428394

chr3:14724311

ENST00000412910

857_860

783.0

Compositional bias

Note=Poly-Ser

Tgene

C3orf20

chr10:90428394

chr3:14724311

ENST00000412910

94_105

783.0

Compositional bias

Note=Poly-Pro

Tgene

C3orf20

chr10:90428394

chr3:14724311

ENST00000435614

575_578

783.0

Compositional bias

Note=Poly-Glu

Tgene

C3orf20

chr10:90428394

chr3:14724311

ENST00000435614

857_860

783.0

Compositional bias

Note=Poly-Ser

Tgene

C3orf20

chr10:90428394

chr3:14724311

ENST00000435614

94_105

783.0

Compositional bias

Note=Poly-Pro

Tgene

C3orf20

chr10:90428394

chr3:14724311

ENST00000253697

778_798

905.0

Transmembrane

Helical

Tgene

C3orf20

chr10:90428394

chr3:14724311

ENST00000412910

778_798

783.0

Transmembrane

Helical

Tgene

C3orf20

chr10:90428394

chr3:14724311

ENST00000435614

778_798

783.0

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

LIPF

chr10:90428394

chr3:14724311

ENST00000238983

78_377

399.0

Domain

AB hydrolase-1

Hgene

LIPF

chr10:90428394

chr3:14724311

ENST00000355843

78_377

376.0

Domain

AB hydrolase-1

Hgene

LIPF

chr10:90428394

chr3:14724311

ENST00000394375

78_377

409.0

Domain

AB hydrolase-1

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Fusion Gene Sequence for LIPF-C3orf20

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>45639_45639_1_LIPF-C3orf20_LIPF_chr10_90428394_ENST00000238983_C3orf20_chr3_14724311_ENST00000253697_length(transcript)=3171nt_BP=388nt
AGAGAAACAGAATCCTAACTATTTCTGAGGAAACTGCAGGTCCAAAATGTGGCTGCTTTTAACAATGGCAAGTTTGATATCTGTACTGGG
GACTACACATGGTTTGTTTGGAAAATTACATCCTGGAAGCCCTGAAGTGACTATGAACATTAGTCAGATGATTACTTATTGGGGATACCC
AAATGAAGAATATGAAGTTGTGACTGAAGATGGTTATATTCTTGAAGTCAATAGAATTCCTTATGGGAAGAAAAATTCAGGGAATACAGC
TTGCCTTCATTCTGGCAGATGCTGGTTATGATGTGTGGCTGGGCAACAGCAGAGGAAACACCTGGGCCAGAAGAAACTTGTACTATTCAC
CAGATTCAGTTGAATTCTGGGCTTTCAGTCTGCCAGAATGCAGGCATTTCTGTACCAAAAGGCATCAGAAACATCTTTGAGTTCACTTGG
GAAGAGCTCATCAGTGACCCTTCAGTGCCTACCCCGTCCGACATCTTGGGCCTGGAGGTCAGCTTTGGAGCCCCCCTGGTGGTGCTCATG
GAACCCACCTTTGTGCAGGTCCCCACACTGAAGAAGCCACTACCTCCACCACCACCAGCACCACCACGTCCAGTGCTGCTGGCAACCACT
GGGGCAGCCAAGCGCTCCACCCTCTCTCCCACCATGGCCCGTCAGGTGCGCACCCACCAGGAGACCCTGAACAGGTTTCAGCAGCAGTCC
ATCCACCTGCTGACGGAGCTCCTCAGACTGAAGATGAAGGCCATGGTGGAGTCTATGTCGGTGGGTGCCAACCCCTTGGACATCACCAGG
CGCTTTGTGGAGGCCAGCCAGCTCCTCCACCTCAATGCCAAGGAGATGGCCTTCAACTGCCTGATCAGCACAGCCGGGAGAAGTGGCTAC
AGCAGCGGACAGTTGTGGAAAGAGTCCCTCGCAAACATGTCCGCCATTGGGGTGAACTCGCCTTACCAGCTGATCTACCACTCTTCCACA
GCCTGTCTGAGCTTTTCTCTCTCTGCTGGAAAAGAAGCCAAGAAGAAAATAGGCAAATCTAGAACTACAGAAGATGTCAGCATGCCGCCC
CTGCATCGAGGAGTGGGAACCCCTGCCAACAGCCTGGAGTTCAGCGACCCCTGCCCTGAGGCCCGGGAGAAGCTGCAGGAGTTGTGTCGC
CACATAGAAGCTGAAAGGGCCACATGGAAAGGGAGGAATATCTCCTACCCCATGATCTTACGAAACTACAAGGCAAAGATGCCCTCTCAT
CTAATGTTGGCCCGCAAAGGAGACTCTCAGACCCCGGGTTTACATTACCCTCCCACTGCAGGTGCTCAGACTCTCAGCCCCACCTCTCAC
CCATCTTCTGCCAACCATCATTTCAGTCAGCATTGTCAAGAGGGGAAGGCACCCAAGAAGGCCTTCAAGTTTCATTACACCTTCTATGAT
GGCTCCTCCTTCGTTTACTATCCCTCTGGAAACGTCGCTGTATGTCAGATCCCCACATGCTGCAGAGGGAGAACCATCACCTGCCTCTTT
AATGACATACCTGGATTCTCCTTGCTGGCCCTATTCAATACTGAAGGCCAGGGCTGTGTTCACTACAACCTAAAAACCAGTTGCCCATAT
GTCTTAATCTTGGATGAGGAAGGTGGGACCACCAATGACCAGCAGGGCTATGTAGTCCACAAGTGGAGCTGGACTTCCAGGACAGAGACC
CTGCTTTCCCTGGAATACAAGGTGAATGAGGAAATGAAACTAAAGGTACTGGGACAGGACTCCATCACAGTCACCTTCACCTCCCTGAAT
GAGACAGTAACACTCACTGTGTCGGCCAACAATTGTCCCCATGGAATGGCATATGACAAACGGCTGAACCGCAGAATCAGCAACATGGAC
GACAAGGTGTATAAGATGAGCCGAGCCCTGGCTGAGATCAAGAAGCGGTTTCAGAAGACAGTGACTCAGTTCATTAATTCTATCTTGCTG
GCCGCAGGTCTGTTTACCATTGAATATCCCACCAAAAAGGAGGAGGAAGAATTTGTTCGGTTCAAGATGAGATCCAGAACTCATCCCGAG
CGGCTCCCCAAGCTAAGTTTATACTCAGGAGAAAGTCTTTTACGATCTCAGTCAGGCCACCTGGAATCCTCAATTGCAGAGACTTTGAAG
GATGAGCCTGAGTCTGCTCCTGTGAGCCCAGTTCGGAAGACCACCAAAATCCACACCAAAGCCAAGGTCACATCCAGAGGGAAGGCCCGC
GAGGGGCGCAGCCCCACCAGGTGGGCGGCCTTGCCCTCAGACTGCCCGCTGGTGCTGCGGAAGCTCATGCTCAAGGAAGACACCCGTGCT
GGCTGCAAGTGCCTGGTGAAGGCGCCCCTGGTCTCTGACGTGGAGCTGGAGCGCTTCCTGTTGGCGCCCCGAGACCCCAGCCAAGTGCTG
GTGTTTGGGATCATCTCAAGCCAGAACTACACCAGCACTGGGCAGCTCCAGTGGCTGCTGAACACTCTCTACAACCACCAGCAGCGGGGC
CGTGGCTCCCCCTGCATCCAGTGCCGGTATGACTCCTACCGCCTGCTGCAGTATGACCTGGACAGCCCCCTGCAGGAGGACCCTCCCCTG
ATGGTGAAGAAGAACTCTGTGGTGCAGGGGATGATTCTGATGTTTGCCGGGGGGAAGCTCATTTTTGGGGGCCGTGTTTTGAATGGATAT
GGCCTCAGCAAGCAGAATCTGCTGAAACAGATCTTCCGGTCTCAACAGGATTACAAGATGGGCTACTTCCTGCCGGATGACTACAAATTC
AGTGTTCCCAACTCTGTCCTGAGCCTGGAGGATTCTGAATCAGTCAAGAAAGCCGAGTCAGAAGATATCCAAGGAAGCAGCTCCTCATTG
GCCCTGGAAGACTATGTGGAGAAGGAGTTATCTCTGGAGGCTGAGAAGACAAGAGAGCCTGAAGTGGAGCTACATCCTCTCAGCAGGGAC
AGCAAGATAACTAGTTGGAAGAAGCAGGCCTCCAAGAAGTAGCGCCATCCTGGCAGCAGCCAAGTGAGCCAGGCCCCGGCCCGGGGTGCT
GGGGCTTCTTGCCAGCCCAGCCCTGCCTCCCCGGTCTCCCACCCTGTCCTCCAAGCTTCTATAATAAACCAGCGGGCCTCCAGCATTGGG

>45639_45639_1_LIPF-C3orf20_LIPF_chr10_90428394_ENST00000238983_C3orf20_chr3_14724311_ENST00000253697_length(amino acids)=913AA_BP=40
MPSFWQMLVMMCGWATAEETPGPEETCTIHQIQLNSGLSVCQNAGISVPKGIRNIFEFTWEELISDPSVPTPSDILGLEVSFGAPLVVLM
EPTFVQVPTLKKPLPPPPPAPPRPVLLATTGAAKRSTLSPTMARQVRTHQETLNRFQQQSIHLLTELLRLKMKAMVESMSVGANPLDITR
RFVEASQLLHLNAKEMAFNCLISTAGRSGYSSGQLWKESLANMSAIGVNSPYQLIYHSSTACLSFSLSAGKEAKKKIGKSRTTEDVSMPP
LHRGVGTPANSLEFSDPCPEAREKLQELCRHIEAERATWKGRNISYPMILRNYKAKMPSHLMLARKGDSQTPGLHYPPTAGAQTLSPTSH
PSSANHHFSQHCQEGKAPKKAFKFHYTFYDGSSFVYYPSGNVAVCQIPTCCRGRTITCLFNDIPGFSLLALFNTEGQGCVHYNLKTSCPY
VLILDEEGGTTNDQQGYVVHKWSWTSRTETLLSLEYKVNEEMKLKVLGQDSITVTFTSLNETVTLTVSANNCPHGMAYDKRLNRRISNMD
DKVYKMSRALAEIKKRFQKTVTQFINSILLAAGLFTIEYPTKKEEEEFVRFKMRSRTHPERLPKLSLYSGESLLRSQSGHLESSIAETLK
DEPESAPVSPVRKTTKIHTKAKVTSRGKAREGRSPTRWAALPSDCPLVLRKLMLKEDTRAGCKCLVKAPLVSDVELERFLLAPRDPSQVL
VFGIISSQNYTSTGQLQWLLNTLYNHQQRGRGSPCIQCRYDSYRLLQYDLDSPLQEDPPLMVKKNSVVQGMILMFAGGKLIFGGRVLNGY
GLSKQNLLKQIFRSQQDYKMGYFLPDDYKFSVPNSVLSLEDSESVKKAESEDIQGSSSSLALEDYVEKELSLEAEKTREPEVELHPLSRD

--------------------------------------------------------------
>45639_45639_2_LIPF-C3orf20_LIPF_chr10_90428394_ENST00000394375_C3orf20_chr3_14724311_ENST00000253697_length(transcript)=3268nt_BP=485nt
AAAATACTAACCAGCCAGAGAAACAGAATCCTAACTATTTCTGAGGAAACTGACTTGGCAACAAGCATTTTGAGAAATTTATTCTGCCCT
TGAACATCTTTGAGCCCATTGAGATGTTCTCCAACGCAAACAGCAGGTCCAAAATGTGGCTGCTTTTAACAATGGCAAGTTTGATATCTG
TACTGGGGACTACACATGGTTTGTTTGGAAAATTACATCCTGGAAGCCCTGAAGTGACTATGAACATTAGTCAGATGATTACTTATTGGG
GATACCCAAATGAAGAATATGAAGTTGTGACTGAAGATGGTTATATTCTTGAAGTCAATAGAATTCCTTATGGGAAGAAAAATTCAGGGA
ATACAGCTTGCCTTCATTCTGGCAGATGCTGGTTATGATGTGTGGCTGGGCAACAGCAGAGGAAACACCTGGGCCAGAAGAAACTTGTAC
TATTCACCAGATTCAGTTGAATTCTGGGCTTTCAGTCTGCCAGAATGCAGGCATTTCTGTACCAAAAGGCATCAGAAACATCTTTGAGTT
CACTTGGGAAGAGCTCATCAGTGACCCTTCAGTGCCTACCCCGTCCGACATCTTGGGCCTGGAGGTCAGCTTTGGAGCCCCCCTGGTGGT
GCTCATGGAACCCACCTTTGTGCAGGTCCCCACACTGAAGAAGCCACTACCTCCACCACCACCAGCACCACCACGTCCAGTGCTGCTGGC
AACCACTGGGGCAGCCAAGCGCTCCACCCTCTCTCCCACCATGGCCCGTCAGGTGCGCACCCACCAGGAGACCCTGAACAGGTTTCAGCA
GCAGTCCATCCACCTGCTGACGGAGCTCCTCAGACTGAAGATGAAGGCCATGGTGGAGTCTATGTCGGTGGGTGCCAACCCCTTGGACAT
CACCAGGCGCTTTGTGGAGGCCAGCCAGCTCCTCCACCTCAATGCCAAGGAGATGGCCTTCAACTGCCTGATCAGCACAGCCGGGAGAAG
TGGCTACAGCAGCGGACAGTTGTGGAAAGAGTCCCTCGCAAACATGTCCGCCATTGGGGTGAACTCGCCTTACCAGCTGATCTACCACTC
TTCCACAGCCTGTCTGAGCTTTTCTCTCTCTGCTGGAAAAGAAGCCAAGAAGAAAATAGGCAAATCTAGAACTACAGAAGATGTCAGCAT
GCCGCCCCTGCATCGAGGAGTGGGAACCCCTGCCAACAGCCTGGAGTTCAGCGACCCCTGCCCTGAGGCCCGGGAGAAGCTGCAGGAGTT
GTGTCGCCACATAGAAGCTGAAAGGGCCACATGGAAAGGGAGGAATATCTCCTACCCCATGATCTTACGAAACTACAAGGCAAAGATGCC
CTCTCATCTAATGTTGGCCCGCAAAGGAGACTCTCAGACCCCGGGTTTACATTACCCTCCCACTGCAGGTGCTCAGACTCTCAGCCCCAC
CTCTCACCCATCTTCTGCCAACCATCATTTCAGTCAGCATTGTCAAGAGGGGAAGGCACCCAAGAAGGCCTTCAAGTTTCATTACACCTT
CTATGATGGCTCCTCCTTCGTTTACTATCCCTCTGGAAACGTCGCTGTATGTCAGATCCCCACATGCTGCAGAGGGAGAACCATCACCTG
CCTCTTTAATGACATACCTGGATTCTCCTTGCTGGCCCTATTCAATACTGAAGGCCAGGGCTGTGTTCACTACAACCTAAAAACCAGTTG
CCCATATGTCTTAATCTTGGATGAGGAAGGTGGGACCACCAATGACCAGCAGGGCTATGTAGTCCACAAGTGGAGCTGGACTTCCAGGAC
AGAGACCCTGCTTTCCCTGGAATACAAGGTGAATGAGGAAATGAAACTAAAGGTACTGGGACAGGACTCCATCACAGTCACCTTCACCTC
CCTGAATGAGACAGTAACACTCACTGTGTCGGCCAACAATTGTCCCCATGGAATGGCATATGACAAACGGCTGAACCGCAGAATCAGCAA
CATGGACGACAAGGTGTATAAGATGAGCCGAGCCCTGGCTGAGATCAAGAAGCGGTTTCAGAAGACAGTGACTCAGTTCATTAATTCTAT
CTTGCTGGCCGCAGGTCTGTTTACCATTGAATATCCCACCAAAAAGGAGGAGGAAGAATTTGTTCGGTTCAAGATGAGATCCAGAACTCA
TCCCGAGCGGCTCCCCAAGCTAAGTTTATACTCAGGAGAAAGTCTTTTACGATCTCAGTCAGGCCACCTGGAATCCTCAATTGCAGAGAC
TTTGAAGGATGAGCCTGAGTCTGCTCCTGTGAGCCCAGTTCGGAAGACCACCAAAATCCACACCAAAGCCAAGGTCACATCCAGAGGGAA
GGCCCGCGAGGGGCGCAGCCCCACCAGGTGGGCGGCCTTGCCCTCAGACTGCCCGCTGGTGCTGCGGAAGCTCATGCTCAAGGAAGACAC
CCGTGCTGGCTGCAAGTGCCTGGTGAAGGCGCCCCTGGTCTCTGACGTGGAGCTGGAGCGCTTCCTGTTGGCGCCCCGAGACCCCAGCCA
AGTGCTGGTGTTTGGGATCATCTCAAGCCAGAACTACACCAGCACTGGGCAGCTCCAGTGGCTGCTGAACACTCTCTACAACCACCAGCA
GCGGGGCCGTGGCTCCCCCTGCATCCAGTGCCGGTATGACTCCTACCGCCTGCTGCAGTATGACCTGGACAGCCCCCTGCAGGAGGACCC
TCCCCTGATGGTGAAGAAGAACTCTGTGGTGCAGGGGATGATTCTGATGTTTGCCGGGGGGAAGCTCATTTTTGGGGGCCGTGTTTTGAA
TGGATATGGCCTCAGCAAGCAGAATCTGCTGAAACAGATCTTCCGGTCTCAACAGGATTACAAGATGGGCTACTTCCTGCCGGATGACTA
CAAATTCAGTGTTCCCAACTCTGTCCTGAGCCTGGAGGATTCTGAATCAGTCAAGAAAGCCGAGTCAGAAGATATCCAAGGAAGCAGCTC
CTCATTGGCCCTGGAAGACTATGTGGAGAAGGAGTTATCTCTGGAGGCTGAGAAGACAAGAGAGCCTGAAGTGGAGCTACATCCTCTCAG
CAGGGACAGCAAGATAACTAGTTGGAAGAAGCAGGCCTCCAAGAAGTAGCGCCATCCTGGCAGCAGCCAAGTGAGCCAGGCCCCGGCCCG
GGGTGCTGGGGCTTCTTGCCAGCCCAGCCCTGCCTCCCCGGTCTCCCACCCTGTCCTCCAAGCTTCTATAATAAACCAGCGGGCCTCCAG

>45639_45639_2_LIPF-C3orf20_LIPF_chr10_90428394_ENST00000394375_C3orf20_chr3_14724311_ENST00000253697_length(amino acids)=913AA_BP=40
MPSFWQMLVMMCGWATAEETPGPEETCTIHQIQLNSGLSVCQNAGISVPKGIRNIFEFTWEELISDPSVPTPSDILGLEVSFGAPLVVLM
EPTFVQVPTLKKPLPPPPPAPPRPVLLATTGAAKRSTLSPTMARQVRTHQETLNRFQQQSIHLLTELLRLKMKAMVESMSVGANPLDITR
RFVEASQLLHLNAKEMAFNCLISTAGRSGYSSGQLWKESLANMSAIGVNSPYQLIYHSSTACLSFSLSAGKEAKKKIGKSRTTEDVSMPP
LHRGVGTPANSLEFSDPCPEAREKLQELCRHIEAERATWKGRNISYPMILRNYKAKMPSHLMLARKGDSQTPGLHYPPTAGAQTLSPTSH
PSSANHHFSQHCQEGKAPKKAFKFHYTFYDGSSFVYYPSGNVAVCQIPTCCRGRTITCLFNDIPGFSLLALFNTEGQGCVHYNLKTSCPY
VLILDEEGGTTNDQQGYVVHKWSWTSRTETLLSLEYKVNEEMKLKVLGQDSITVTFTSLNETVTLTVSANNCPHGMAYDKRLNRRISNMD
DKVYKMSRALAEIKKRFQKTVTQFINSILLAAGLFTIEYPTKKEEEEFVRFKMRSRTHPERLPKLSLYSGESLLRSQSGHLESSIAETLK
DEPESAPVSPVRKTTKIHTKAKVTSRGKAREGRSPTRWAALPSDCPLVLRKLMLKEDTRAGCKCLVKAPLVSDVELERFLLAPRDPSQVL
VFGIISSQNYTSTGQLQWLLNTLYNHQQRGRGSPCIQCRYDSYRLLQYDLDSPLQEDPPLMVKKNSVVQGMILMFAGGKLIFGGRVLNGY
GLSKQNLLKQIFRSQQDYKMGYFLPDDYKFSVPNSVLSLEDSESVKKAESEDIQGSSSSLALEDYVEKELSLEAEKTREPEVELHPLSRD

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Fusion Gene PPI Analysis for LIPF-C3orf20

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for LIPF-C3orf20

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for LIPF-C3orf20

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source