Home

Download

Statistics

Examples

Help

Contact

	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:LIPH-VPS8 (FusionGDB2 ID:45660)

Fusion Gene Summary for LIPH-VPS8

Fusion gene summary

Fusion gene information	Fusion gene name: LIPH-VPS8
	Fusion gene ID: 45660
		Hgene	Tgene
	Gene symbol	LIPH	VPS8
	Gene ID	200879	23355
	Gene name	lipase H	VPS8 subunit of CORVET complex
	Synonyms	AH\|ARWH2\|HYPT7\|LAH2\|LPDLR\|PLA1B\|mPA-PLA1	KIAA0804
	Cytomap	3q27.2	3q27.2
	Type of gene	protein-coding	protein-coding
	Description	lipase member HLPD lipase-related proteinlipase, member HmPA-PLA1 alphamembrane-associated phosphatidic acid-selective phospholipase A1-alphamembrane-bound phosphatidic acid-selective phospholipase A1phospholipase A(1)phospholipase A1 member B	vacuolar protein sorting-associated protein 8 homologVPS8, CORVET complex subunitvacuolar protein sorting 8 homolog
	Modification date	20200313	20200313
	UniProtAcc	Q8WWY8	.
	Ensembl transtripts involved in fusion gene	ENST00000296252, ENST00000424591,	ENST00000424463, ENST00000463687, ENST00000287546, ENST00000436792, ENST00000437079, ENST00000446204,
Fusion gene scores	* DoF score	6 X 4 X 5=120	9 X 10 X 6=540
	# samples	6	9
	** MAII score	log2(6/120*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(9/540*10)=-2.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: LIPH [Title/Abstract] AND VPS8 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	LIPH(185270210)-VPS8(184766266), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	LIPH	GO:0016042	lipid catabolic process	12963729

Fusion gene breakpoints across LIPH (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across VPS8 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	OV	TCGA-13-0765	LIPH	chr3	185270210	-	VPS8	chr3	184766266	+

Top

Fusion Gene ORF analysis for LIPH-VPS8

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000296252	ENST00000424463	LIPH	chr3	185270210	-	VPS8	chr3	184766266	+
5CDS-intron	ENST00000296252	ENST00000463687	LIPH	chr3	185270210	-	VPS8	chr3	184766266	+
5CDS-intron	ENST00000424591	ENST00000424463	LIPH	chr3	185270210	-	VPS8	chr3	184766266	+
5CDS-intron	ENST00000424591	ENST00000463687	LIPH	chr3	185270210	-	VPS8	chr3	184766266	+
In-frame	ENST00000296252	ENST00000287546	LIPH	chr3	185270210	-	VPS8	chr3	184766266	+
In-frame	ENST00000296252	ENST00000436792	LIPH	chr3	185270210	-	VPS8	chr3	184766266	+
In-frame	ENST00000296252	ENST00000437079	LIPH	chr3	185270210	-	VPS8	chr3	184766266	+
In-frame	ENST00000296252	ENST00000446204	LIPH	chr3	185270210	-	VPS8	chr3	184766266	+
In-frame	ENST00000424591	ENST00000287546	LIPH	chr3	185270210	-	VPS8	chr3	184766266	+
In-frame	ENST00000424591	ENST00000436792	LIPH	chr3	185270210	-	VPS8	chr3	184766266	+
In-frame	ENST00000424591	ENST00000437079	LIPH	chr3	185270210	-	VPS8	chr3	184766266	+
In-frame	ENST00000424591	ENST00000446204	LIPH	chr3	185270210	-	VPS8	chr3	184766266	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000296252	LIPH	chr3	185270210	-	ENST00000437079	VPS8	chr3	184766266	+	1011	191	616	197	139
ENST00000296252	LIPH	chr3	185270210	-	ENST00000287546	VPS8	chr3	184766266	+	1011	191	616	197	139
ENST00000296252	LIPH	chr3	185270210	-	ENST00000436792	VPS8	chr3	184766266	+	1009	191	582	316	88
ENST00000296252	LIPH	chr3	185270210	-	ENST00000446204	VPS8	chr3	184766266	+	1001	191	616	197	139
ENST00000424591	LIPH	chr3	185270210	-	ENST00000437079	VPS8	chr3	184766266	+	956	136	561	142	139
ENST00000424591	LIPH	chr3	185270210	-	ENST00000287546	VPS8	chr3	184766266	+	956	136	561	142	139
ENST00000424591	LIPH	chr3	185270210	-	ENST00000436792	VPS8	chr3	184766266	+	954	136	527	261	88
ENST00000424591	LIPH	chr3	185270210	-	ENST00000446204	VPS8	chr3	184766266	+	946	136	561	142	139

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000296252	ENST00000437079	LIPH	chr3	185270210	-	VPS8	chr3	184766266	+	0.7540323	0.2459677
ENST00000296252	ENST00000287546	LIPH	chr3	185270210	-	VPS8	chr3	184766266	+	0.7540323	0.2459677
ENST00000296252	ENST00000436792	LIPH	chr3	185270210	-	VPS8	chr3	184766266	+	0.7517145	0.24828547
ENST00000296252	ENST00000446204	LIPH	chr3	185270210	-	VPS8	chr3	184766266	+	0.7945878	0.20541225
ENST00000424591	ENST00000437079	LIPH	chr3	185270210	-	VPS8	chr3	184766266	+	0.77385825	0.2261417
ENST00000424591	ENST00000287546	LIPH	chr3	185270210	-	VPS8	chr3	184766266	+	0.77385825	0.2261417
ENST00000424591	ENST00000436792	LIPH	chr3	185270210	-	VPS8	chr3	184766266	+	0.7714195	0.22858047
ENST00000424591	ENST00000446204	LIPH	chr3	185270210	-	VPS8	chr3	184766266	+	0.7962695	0.20373051

Top

Fusion Genomic Features for LIPH-VPS8

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
LIPH	chr3	185270210	-	VPS8	chr3	184766266	+	0.013061918	0.9869381
LIPH	chr3	185270210	-	VPS8	chr3	184766266	+	0.013061918	0.9869381

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for LIPH-VPS8

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:185270210/chr3:184766266)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
LIPH Q8WWY8	.
FUNCTION: Hydrolyzes specifically phosphatidic acid (PA) to produce 2-acyl lysophosphatidic acid (LPA; a potent bioactive lipid mediator) and fatty acid. Does not hydrolyze other phospholipids, like phosphatidylserine (PS), phosphatidylcholine (PC) and phosphatidylethanolamine (PE) or triacylglycerol (TG). {ECO:0000269\|PubMed:12063250, ECO:0000269\|PubMed:12963729}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

VPS8

chr3:185270210

chr3:184766266

ENST00000446204

1258_1310

1260

1337.0

Zinc finger

RING-type%3B atypical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

VPS8

chr3:185270210

chr3:184766266

ENST00000436792

195_236

1350

1427.0

Repeat

Note=WD

Tgene

VPS8

chr3:185270210

chr3:184766266

ENST00000437079

195_236

1352

1429.0

Repeat

Note=WD

Tgene

VPS8

chr3:185270210

chr3:184766266

ENST00000446204

195_236

1260

1337.0

Repeat

Note=WD

Tgene

VPS8

chr3:185270210

chr3:184766266

ENST00000436792

1258_1310

1350

1427.0

Zinc finger

RING-type%3B atypical

Tgene

VPS8

chr3:185270210

chr3:184766266

ENST00000437079

1258_1310

1352

1429.0

Zinc finger

RING-type%3B atypical

Top

Fusion Gene Sequence for LIPH-VPS8

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>45660_45660_1_LIPH-VPS8_LIPH_chr3_185270210_ENST00000296252_VPS8_chr3_184766266_ENST00000287546_length(transcript)=1011nt_BP=191nt
AGTCCCTAGGGAACTTCCTGTTGTCACCACACCTCTGAGTCGTCTGAGCTCACTGTGAGCAAAATCCCACAGTGGAAACTCTTAAGCCTC
TGCGAAGTAAATCATTCTTGTGAATGTGACACACGATCTCTCCAGTTTCCATATGTTGAGATTCTACTTATTCATCAGTTTGTTGTGCTT
GTCAAGATCAGGGAACCTCAGAACCTGTTCTGGATCCACAGCAAATCCAAGCATTTGATCAGCTTTGCCGTCTCTACCGAGGAAGCTCCA
GGCTGGCTCTCCTCACGGAACTCTCCCAGAATCGCAGCAGCGAGAGCTATAGGCCATTCAGTGGCTCGCAGAGTGCTCCTGCTTTCAACA
GCATCTTCCAGAATGAGAACTTCCAGCTGCAGCTCATTCCTCCACCTGTGACTGAGGATTGATGACTCCATGGAGCCTGGCCCAGGAGAA
CCAGAGATGATCCCGAGGCAGCTGGGGAGAGGCCCCGCCTCTGGTGGGCTTGGCCTCCACCACCTCCCACGCTTCTGAGAAGAGGTTCCA
AATTGGGCTTCTGTGCCCAGAGCGTCCACAGCACCATTCCCAGTGTAGACTCCCAGTCTTCTCCACATTGCTGTCATGGCGTCAGTTCAC
CAGACTCATTGATTTTGTTTTGCTTGTTAAGCAAAGGAATGTCACATACCTCTGTCCAGCTTTTTAGGAAATACATTTCGCCTATTGCGA
CTTTTTCCATTTACCCTGAAGCCTAGAAAGTAGGTGGAACTCACACAAATGGCATTCCAGAGTCTGCCATACTCCGTCTCCTCCAGCTGC
TGGATAATACAGAGGAACTTCAACTTCTACAGGGAACAGTGGTTGGCCAGGCTGCAGTATAACTGAAGCATGCCTTGGAGAGAGCAGACA
CTGTGGGGGCCAGGGCCATCTCCCTTTAATGTGTTCATGTTAAAACCTATTTGAGTGTAAGACTTGCCCTTTCTAACAATAAATGCTCCG

>45660_45660_1_LIPH-VPS8_LIPH_chr3_185270210_ENST00000296252_VPS8_chr3_184766266_ENST00000287546_length(amino acids)=139AA_BP=
MTAMWRRLGVYTGNGAVDALGTEAQFGTSSQKRGRWWRPSPPEAGPLPSCLGIISGSPGPGSMESSILSHRWRNELQLEVLILEDAVESR

--------------------------------------------------------------
>45660_45660_2_LIPH-VPS8_LIPH_chr3_185270210_ENST00000296252_VPS8_chr3_184766266_ENST00000436792_length(transcript)=1009nt_BP=191nt
AGTCCCTAGGGAACTTCCTGTTGTCACCACACCTCTGAGTCGTCTGAGCTCACTGTGAGCAAAATCCCACAGTGGAAACTCTTAAGCCTC
TGCGAAGTAAATCATTCTTGTGAATGTGACACACGATCTCTCCAGTTTCCATATGTTGAGATTCTACTTATTCATCAGTTTGTTGTGCTT
GTCAAGATCAGGGAACCTCAGAACCTGTTCTGGATCCACAGCAAATCCAAGCATTTGATCAGCTTTGCCGTCTCTACCGAGGAAGCTCCA
GGCTGGCTCTCCTCACGGAACTCTCCCAGAATCGCAGCAGCGAGAGCTATAGGCCATTCAGTGGCTCGCAGAGTGCTCCTGCTTTCAACA
GCATCTTCCAGAATGAGAACTTCCAGCTGCAGCTCATTCCTCCACCTGTGACTGAGGATTGATGACTCCATGGAGCCTGGCCCAGGAGAA
CCAGAGATGATCCCGAGGCAGCTGGGGAGAGGCCCCGCCTCTGGTGGGCTTGGCCTCCACCACCTCCCACGCTTCTGAGAAGAGGTTCCA
AATTGGGCTTCTGTGCCCAGAGCGTCCACAGCACCATTCCCAGTGTAGACTCCCAGTCTTCTCCACATTGCTGTCATGGCGTCAGTTCAC
CAGACTCATTGATTTTGTTTTGCTTGTTAAGCAAAGGAATGTCACATACCTCTGTCCAGCTTTTTAGGAAATACATTTCGCCTATTGCGA
CTTTTTCCATTTACCCTGAAGCCTAGAAAGTAGGTGGAACTCACACAAATGGCATTCCAGAGTCTGCCATACTCCGTCTCCTCCAGCTGC
TGGATAATACAGAGGAACTTCAACTTCTACAGGGAACAGTGGTTGGCCAGGCTGCAGTATAACTGAAGCATGCCTTGGAGAGAGCAGACA
CTGTGGGGGCCAGGGCCATCTCCCTTTAATGTGTTCATGTTAAAACCTATTTGAGTGTAAGACTTGCCCTTTCTAACAATAAATGCTCCG

>45660_45660_2_LIPH-VPS8_LIPH_chr3_185270210_ENST00000296252_VPS8_chr3_184766266_ENST00000436792_length(amino acids)=88AA_BP=

--------------------------------------------------------------
>45660_45660_3_LIPH-VPS8_LIPH_chr3_185270210_ENST00000296252_VPS8_chr3_184766266_ENST00000437079_length(transcript)=1011nt_BP=191nt
AGTCCCTAGGGAACTTCCTGTTGTCACCACACCTCTGAGTCGTCTGAGCTCACTGTGAGCAAAATCCCACAGTGGAAACTCTTAAGCCTC
TGCGAAGTAAATCATTCTTGTGAATGTGACACACGATCTCTCCAGTTTCCATATGTTGAGATTCTACTTATTCATCAGTTTGTTGTGCTT
GTCAAGATCAGGGAACCTCAGAACCTGTTCTGGATCCACAGCAAATCCAAGCATTTGATCAGCTTTGCCGTCTCTACCGAGGAAGCTCCA
GGCTGGCTCTCCTCACGGAACTCTCCCAGAATCGCAGCAGCGAGAGCTATAGGCCATTCAGTGGCTCGCAGAGTGCTCCTGCTTTCAACA
GCATCTTCCAGAATGAGAACTTCCAGCTGCAGCTCATTCCTCCACCTGTGACTGAGGATTGATGACTCCATGGAGCCTGGCCCAGGAGAA
CCAGAGATGATCCCGAGGCAGCTGGGGAGAGGCCCCGCCTCTGGTGGGCTTGGCCTCCACCACCTCCCACGCTTCTGAGAAGAGGTTCCA
AATTGGGCTTCTGTGCCCAGAGCGTCCACAGCACCATTCCCAGTGTAGACTCCCAGTCTTCTCCACATTGCTGTCATGGCGTCAGTTCAC
CAGACTCATTGATTTTGTTTTGCTTGTTAAGCAAAGGAATGTCACATACCTCTGTCCAGCTTTTTAGGAAATACATTTCGCCTATTGCGA
CTTTTTCCATTTACCCTGAAGCCTAGAAAGTAGGTGGAACTCACACAAATGGCATTCCAGAGTCTGCCATACTCCGTCTCCTCCAGCTGC
TGGATAATACAGAGGAACTTCAACTTCTACAGGGAACAGTGGTTGGCCAGGCTGCAGTATAACTGAAGCATGCCTTGGAGAGAGCAGACA
CTGTGGGGGCCAGGGCCATCTCCCTTTAATGTGTTCATGTTAAAACCTATTTGAGTGTAAGACTTGCCCTTTCTAACAATAAATGCTCCG

>45660_45660_3_LIPH-VPS8_LIPH_chr3_185270210_ENST00000296252_VPS8_chr3_184766266_ENST00000437079_length(amino acids)=139AA_BP=
MTAMWRRLGVYTGNGAVDALGTEAQFGTSSQKRGRWWRPSPPEAGPLPSCLGIISGSPGPGSMESSILSHRWRNELQLEVLILEDAVESR

--------------------------------------------------------------
>45660_45660_4_LIPH-VPS8_LIPH_chr3_185270210_ENST00000296252_VPS8_chr3_184766266_ENST00000446204_length(transcript)=1001nt_BP=191nt
AGTCCCTAGGGAACTTCCTGTTGTCACCACACCTCTGAGTCGTCTGAGCTCACTGTGAGCAAAATCCCACAGTGGAAACTCTTAAGCCTC
TGCGAAGTAAATCATTCTTGTGAATGTGACACACGATCTCTCCAGTTTCCATATGTTGAGATTCTACTTATTCATCAGTTTGTTGTGCTT
GTCAAGATCAGGGAACCTCAGAACCTGTTCTGGATCCACAGCAAATCCAAGCATTTGATCAGCTTTGCCGTCTCTACCGAGGAAGCTCCA
GGCTGGCTCTCCTCACGGAACTCTCCCAGAATCGCAGCAGCGAGAGCTATAGGCCATTCAGTGGCTCGCAGAGTGCTCCTGCTTTCAACA
GCATCTTCCAGAATGAGAACTTCCAGCTGCAGCTCATTCCTCCACCTGTGACTGAGGATTGATGACTCCATGGAGCCTGGCCCAGGAGAA
CCAGAGATGATCCCGAGGCAGCTGGGGAGAGGCCCCGCCTCTGGTGGGCTTGGCCTCCACCACCTCCCACGCTTCTGAGAAGAGGTTCCA
AATTGGGCTTCTGTGCCCAGAGCGTCCACAGCACCATTCCCAGTGTAGACTCCCAGTCTTCTCCACATTGCTGTCATGGCGTCAGTTCAC
CAGACTCATTGATTTTGTTTTGCTTGTTAAGCAAAGGAATGTCACATACCTCTGTCCAGCTTTTTAGGAAATACATTTCGCCTATTGCGA
CTTTTTCCATTTACCCTGAAGCCTAGAAAGTAGGTGGAACTCACACAAATGGCATTCCAGAGTCTGCCATACTCCGTCTCCTCCAGCTGC
TGGATAATACAGAGGAACTTCAACTTCTACAGGGAACAGTGGTTGGCCAGGCTGCAGTATAACTGAAGCATGCCTTGGAGAGAGCAGACA
CTGTGGGGGCCAGGGCCATCTCCCTTTAATGTGTTCATGTTAAAACCTATTTGAGTGTAAGACTTGCCCTTTCTAACAATAAATGCTCCG

>45660_45660_4_LIPH-VPS8_LIPH_chr3_185270210_ENST00000296252_VPS8_chr3_184766266_ENST00000446204_length(amino acids)=139AA_BP=
MTAMWRRLGVYTGNGAVDALGTEAQFGTSSQKRGRWWRPSPPEAGPLPSCLGIISGSPGPGSMESSILSHRWRNELQLEVLILEDAVESR

--------------------------------------------------------------
>45660_45660_5_LIPH-VPS8_LIPH_chr3_185270210_ENST00000424591_VPS8_chr3_184766266_ENST00000287546_length(transcript)=956nt_BP=136nt
TGAGCAAAATCCCACAGTGGAAACTCTTAAGCCTCTGCGAAGTAAATCATTCTTGTGAATGTGACACACGATCTCTCCAGTTTCCATATG
TTGAGATTCTACTTATTCATCAGTTTGTTGTGCTTGTCAAGATCAGGGAACCTCAGAACCTGTTCTGGATCCACAGCAAATCCAAGCATT
TGATCAGCTTTGCCGTCTCTACCGAGGAAGCTCCAGGCTGGCTCTCCTCACGGAACTCTCCCAGAATCGCAGCAGCGAGAGCTATAGGCC
ATTCAGTGGCTCGCAGAGTGCTCCTGCTTTCAACAGCATCTTCCAGAATGAGAACTTCCAGCTGCAGCTCATTCCTCCACCTGTGACTGA
GGATTGATGACTCCATGGAGCCTGGCCCAGGAGAACCAGAGATGATCCCGAGGCAGCTGGGGAGAGGCCCCGCCTCTGGTGGGCTTGGCC
TCCACCACCTCCCACGCTTCTGAGAAGAGGTTCCAAATTGGGCTTCTGTGCCCAGAGCGTCCACAGCACCATTCCCAGTGTAGACTCCCA
GTCTTCTCCACATTGCTGTCATGGCGTCAGTTCACCAGACTCATTGATTTTGTTTTGCTTGTTAAGCAAAGGAATGTCACATACCTCTGT
CCAGCTTTTTAGGAAATACATTTCGCCTATTGCGACTTTTTCCATTTACCCTGAAGCCTAGAAAGTAGGTGGAACTCACACAAATGGCAT
TCCAGAGTCTGCCATACTCCGTCTCCTCCAGCTGCTGGATAATACAGAGGAACTTCAACTTCTACAGGGAACAGTGGTTGGCCAGGCTGC
AGTATAACTGAAGCATGCCTTGGAGAGAGCAGACACTGTGGGGGCCAGGGCCATCTCCCTTTAATGTGTTCATGTTAAAACCTATTTGAG

>45660_45660_5_LIPH-VPS8_LIPH_chr3_185270210_ENST00000424591_VPS8_chr3_184766266_ENST00000287546_length(amino acids)=139AA_BP=
MTAMWRRLGVYTGNGAVDALGTEAQFGTSSQKRGRWWRPSPPEAGPLPSCLGIISGSPGPGSMESSILSHRWRNELQLEVLILEDAVESR

--------------------------------------------------------------
>45660_45660_6_LIPH-VPS8_LIPH_chr3_185270210_ENST00000424591_VPS8_chr3_184766266_ENST00000436792_length(transcript)=954nt_BP=136nt
TGAGCAAAATCCCACAGTGGAAACTCTTAAGCCTCTGCGAAGTAAATCATTCTTGTGAATGTGACACACGATCTCTCCAGTTTCCATATG
TTGAGATTCTACTTATTCATCAGTTTGTTGTGCTTGTCAAGATCAGGGAACCTCAGAACCTGTTCTGGATCCACAGCAAATCCAAGCATT
TGATCAGCTTTGCCGTCTCTACCGAGGAAGCTCCAGGCTGGCTCTCCTCACGGAACTCTCCCAGAATCGCAGCAGCGAGAGCTATAGGCC
ATTCAGTGGCTCGCAGAGTGCTCCTGCTTTCAACAGCATCTTCCAGAATGAGAACTTCCAGCTGCAGCTCATTCCTCCACCTGTGACTGA
GGATTGATGACTCCATGGAGCCTGGCCCAGGAGAACCAGAGATGATCCCGAGGCAGCTGGGGAGAGGCCCCGCCTCTGGTGGGCTTGGCC
TCCACCACCTCCCACGCTTCTGAGAAGAGGTTCCAAATTGGGCTTCTGTGCCCAGAGCGTCCACAGCACCATTCCCAGTGTAGACTCCCA
GTCTTCTCCACATTGCTGTCATGGCGTCAGTTCACCAGACTCATTGATTTTGTTTTGCTTGTTAAGCAAAGGAATGTCACATACCTCTGT
CCAGCTTTTTAGGAAATACATTTCGCCTATTGCGACTTTTTCCATTTACCCTGAAGCCTAGAAAGTAGGTGGAACTCACACAAATGGCAT
TCCAGAGTCTGCCATACTCCGTCTCCTCCAGCTGCTGGATAATACAGAGGAACTTCAACTTCTACAGGGAACAGTGGTTGGCCAGGCTGC
AGTATAACTGAAGCATGCCTTGGAGAGAGCAGACACTGTGGGGGCCAGGGCCATCTCCCTTTAATGTGTTCATGTTAAAACCTATTTGAG

>45660_45660_6_LIPH-VPS8_LIPH_chr3_185270210_ENST00000424591_VPS8_chr3_184766266_ENST00000436792_length(amino acids)=88AA_BP=

--------------------------------------------------------------
>45660_45660_7_LIPH-VPS8_LIPH_chr3_185270210_ENST00000424591_VPS8_chr3_184766266_ENST00000437079_length(transcript)=956nt_BP=136nt
TGAGCAAAATCCCACAGTGGAAACTCTTAAGCCTCTGCGAAGTAAATCATTCTTGTGAATGTGACACACGATCTCTCCAGTTTCCATATG
TTGAGATTCTACTTATTCATCAGTTTGTTGTGCTTGTCAAGATCAGGGAACCTCAGAACCTGTTCTGGATCCACAGCAAATCCAAGCATT
TGATCAGCTTTGCCGTCTCTACCGAGGAAGCTCCAGGCTGGCTCTCCTCACGGAACTCTCCCAGAATCGCAGCAGCGAGAGCTATAGGCC
ATTCAGTGGCTCGCAGAGTGCTCCTGCTTTCAACAGCATCTTCCAGAATGAGAACTTCCAGCTGCAGCTCATTCCTCCACCTGTGACTGA
GGATTGATGACTCCATGGAGCCTGGCCCAGGAGAACCAGAGATGATCCCGAGGCAGCTGGGGAGAGGCCCCGCCTCTGGTGGGCTTGGCC
TCCACCACCTCCCACGCTTCTGAGAAGAGGTTCCAAATTGGGCTTCTGTGCCCAGAGCGTCCACAGCACCATTCCCAGTGTAGACTCCCA
GTCTTCTCCACATTGCTGTCATGGCGTCAGTTCACCAGACTCATTGATTTTGTTTTGCTTGTTAAGCAAAGGAATGTCACATACCTCTGT
CCAGCTTTTTAGGAAATACATTTCGCCTATTGCGACTTTTTCCATTTACCCTGAAGCCTAGAAAGTAGGTGGAACTCACACAAATGGCAT
TCCAGAGTCTGCCATACTCCGTCTCCTCCAGCTGCTGGATAATACAGAGGAACTTCAACTTCTACAGGGAACAGTGGTTGGCCAGGCTGC
AGTATAACTGAAGCATGCCTTGGAGAGAGCAGACACTGTGGGGGCCAGGGCCATCTCCCTTTAATGTGTTCATGTTAAAACCTATTTGAG

>45660_45660_7_LIPH-VPS8_LIPH_chr3_185270210_ENST00000424591_VPS8_chr3_184766266_ENST00000437079_length(amino acids)=139AA_BP=
MTAMWRRLGVYTGNGAVDALGTEAQFGTSSQKRGRWWRPSPPEAGPLPSCLGIISGSPGPGSMESSILSHRWRNELQLEVLILEDAVESR

--------------------------------------------------------------
>45660_45660_8_LIPH-VPS8_LIPH_chr3_185270210_ENST00000424591_VPS8_chr3_184766266_ENST00000446204_length(transcript)=946nt_BP=136nt
TGAGCAAAATCCCACAGTGGAAACTCTTAAGCCTCTGCGAAGTAAATCATTCTTGTGAATGTGACACACGATCTCTCCAGTTTCCATATG
TTGAGATTCTACTTATTCATCAGTTTGTTGTGCTTGTCAAGATCAGGGAACCTCAGAACCTGTTCTGGATCCACAGCAAATCCAAGCATT
TGATCAGCTTTGCCGTCTCTACCGAGGAAGCTCCAGGCTGGCTCTCCTCACGGAACTCTCCCAGAATCGCAGCAGCGAGAGCTATAGGCC
ATTCAGTGGCTCGCAGAGTGCTCCTGCTTTCAACAGCATCTTCCAGAATGAGAACTTCCAGCTGCAGCTCATTCCTCCACCTGTGACTGA
GGATTGATGACTCCATGGAGCCTGGCCCAGGAGAACCAGAGATGATCCCGAGGCAGCTGGGGAGAGGCCCCGCCTCTGGTGGGCTTGGCC
TCCACCACCTCCCACGCTTCTGAGAAGAGGTTCCAAATTGGGCTTCTGTGCCCAGAGCGTCCACAGCACCATTCCCAGTGTAGACTCCCA
GTCTTCTCCACATTGCTGTCATGGCGTCAGTTCACCAGACTCATTGATTTTGTTTTGCTTGTTAAGCAAAGGAATGTCACATACCTCTGT
CCAGCTTTTTAGGAAATACATTTCGCCTATTGCGACTTTTTCCATTTACCCTGAAGCCTAGAAAGTAGGTGGAACTCACACAAATGGCAT
TCCAGAGTCTGCCATACTCCGTCTCCTCCAGCTGCTGGATAATACAGAGGAACTTCAACTTCTACAGGGAACAGTGGTTGGCCAGGCTGC
AGTATAACTGAAGCATGCCTTGGAGAGAGCAGACACTGTGGGGGCCAGGGCCATCTCCCTTTAATGTGTTCATGTTAAAACCTATTTGAG

>45660_45660_8_LIPH-VPS8_LIPH_chr3_185270210_ENST00000424591_VPS8_chr3_184766266_ENST00000446204_length(amino acids)=139AA_BP=
MTAMWRRLGVYTGNGAVDALGTEAQFGTSSQKRGRWWRPSPPEAGPLPSCLGIISGSPGPGSMESSILSHRWRNELQLEVLILEDAVESR

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for LIPH-VPS8

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for LIPH-VPS8

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for LIPH-VPS8

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source