Home

Download

Statistics

Examples

Help

Contact

	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:LITAF-DBNL (FusionGDB2 ID:45672)

Fusion Gene Summary for LITAF-DBNL

Fusion gene summary

Fusion gene information	Fusion gene name: LITAF-DBNL
	Fusion gene ID: 45672
		Hgene	Tgene
	Gene symbol	LITAF	DBNL
	Gene ID	9516	28988
	Gene name	lipopolysaccharide induced TNF factor	drebrin like
	Synonyms	PIG7\|SIMPLE\|TP53I7	ABP1\|HIP-55\|HIP55\|SH3P7
	Cytomap	16p13.13	7p13
	Type of gene	protein-coding	protein-coding
	Description	lipopolysaccharide-induced tumor necrosis factor-alpha factorLPS-induced TNF-alpha factorlipopolysaccharide-induced TNF-alpha factorp53-induced gene 7 proteinsmall integral membrane protein of lysosome/late endosometumor protein p53 inducible protein	drebrin-like proteinHPK1-interacting protein of 55 kDaSH3 domain-containing protein 7actin-binding protein 1cervical SH3P7cervical mucin-associated proteindrebrin-Fsrc homology 3 domain-containing protein HIP-55
	Modification date	20200328	20200313
	UniProtAcc	Q99732	Q9UJU6
	Ensembl transtripts involved in fusion gene	ENST00000339430, ENST00000381810, ENST00000413364, ENST00000570904, ENST00000571459, ENST00000571688, ENST00000571976, ENST00000572255, ENST00000574703, ENST00000574763, ENST00000576036,	ENST00000440166, ENST00000448521, ENST00000452943, ENST00000456905, ENST00000468694, ENST00000490734, ENST00000494774, ENST00000497184,
Fusion gene scores	* DoF score	11 X 12 X 6=792	4 X 4 X 1=16
	# samples	17	4
	** MAII score	log2(17/792*10)=-2.21996568394191 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(4/16*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: LITAF [Title/Abstract] AND DBNL [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	LITAF(11642974)-DBNL(44085791), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across LITAF (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across DBNL (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS5.0	N/A	BE830303	LITAF	chr16	11642974	-	DBNL	chr7	44085791	+

Top

Fusion Gene ORF analysis for LITAF-DBNL

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-intron	ENST00000339430	ENST00000440166	LITAF	chr16	11642974	-	DBNL	chr7	44085791	+
intron-intron	ENST00000339430	ENST00000448521	LITAF	chr16	11642974	-	DBNL	chr7	44085791	+
intron-intron	ENST00000339430	ENST00000452943	LITAF	chr16	11642974	-	DBNL	chr7	44085791	+
intron-intron	ENST00000339430	ENST00000456905	LITAF	chr16	11642974	-	DBNL	chr7	44085791	+
intron-intron	ENST00000339430	ENST00000468694	LITAF	chr16	11642974	-	DBNL	chr7	44085791	+
intron-intron	ENST00000339430	ENST00000490734	LITAF	chr16	11642974	-	DBNL	chr7	44085791	+
intron-intron	ENST00000339430	ENST00000494774	LITAF	chr16	11642974	-	DBNL	chr7	44085791	+
intron-intron	ENST00000339430	ENST00000497184	LITAF	chr16	11642974	-	DBNL	chr7	44085791	+
intron-intron	ENST00000381810	ENST00000440166	LITAF	chr16	11642974	-	DBNL	chr7	44085791	+
intron-intron	ENST00000381810	ENST00000448521	LITAF	chr16	11642974	-	DBNL	chr7	44085791	+
intron-intron	ENST00000381810	ENST00000452943	LITAF	chr16	11642974	-	DBNL	chr7	44085791	+
intron-intron	ENST00000381810	ENST00000456905	LITAF	chr16	11642974	-	DBNL	chr7	44085791	+
intron-intron	ENST00000381810	ENST00000468694	LITAF	chr16	11642974	-	DBNL	chr7	44085791	+
intron-intron	ENST00000381810	ENST00000490734	LITAF	chr16	11642974	-	DBNL	chr7	44085791	+
intron-intron	ENST00000381810	ENST00000494774	LITAF	chr16	11642974	-	DBNL	chr7	44085791	+
intron-intron	ENST00000381810	ENST00000497184	LITAF	chr16	11642974	-	DBNL	chr7	44085791	+
intron-intron	ENST00000413364	ENST00000440166	LITAF	chr16	11642974	-	DBNL	chr7	44085791	+
intron-intron	ENST00000413364	ENST00000448521	LITAF	chr16	11642974	-	DBNL	chr7	44085791	+
intron-intron	ENST00000413364	ENST00000452943	LITAF	chr16	11642974	-	DBNL	chr7	44085791	+
intron-intron	ENST00000413364	ENST00000456905	LITAF	chr16	11642974	-	DBNL	chr7	44085791	+
intron-intron	ENST00000413364	ENST00000468694	LITAF	chr16	11642974	-	DBNL	chr7	44085791	+
intron-intron	ENST00000413364	ENST00000490734	LITAF	chr16	11642974	-	DBNL	chr7	44085791	+
intron-intron	ENST00000413364	ENST00000494774	LITAF	chr16	11642974	-	DBNL	chr7	44085791	+
intron-intron	ENST00000413364	ENST00000497184	LITAF	chr16	11642974	-	DBNL	chr7	44085791	+
intron-intron	ENST00000570904	ENST00000440166	LITAF	chr16	11642974	-	DBNL	chr7	44085791	+
intron-intron	ENST00000570904	ENST00000448521	LITAF	chr16	11642974	-	DBNL	chr7	44085791	+
intron-intron	ENST00000570904	ENST00000452943	LITAF	chr16	11642974	-	DBNL	chr7	44085791	+
intron-intron	ENST00000570904	ENST00000456905	LITAF	chr16	11642974	-	DBNL	chr7	44085791	+
intron-intron	ENST00000570904	ENST00000468694	LITAF	chr16	11642974	-	DBNL	chr7	44085791	+
intron-intron	ENST00000570904	ENST00000490734	LITAF	chr16	11642974	-	DBNL	chr7	44085791	+
intron-intron	ENST00000570904	ENST00000494774	LITAF	chr16	11642974	-	DBNL	chr7	44085791	+
intron-intron	ENST00000570904	ENST00000497184	LITAF	chr16	11642974	-	DBNL	chr7	44085791	+
intron-intron	ENST00000571459	ENST00000440166	LITAF	chr16	11642974	-	DBNL	chr7	44085791	+
intron-intron	ENST00000571459	ENST00000448521	LITAF	chr16	11642974	-	DBNL	chr7	44085791	+
intron-intron	ENST00000571459	ENST00000452943	LITAF	chr16	11642974	-	DBNL	chr7	44085791	+
intron-intron	ENST00000571459	ENST00000456905	LITAF	chr16	11642974	-	DBNL	chr7	44085791	+
intron-intron	ENST00000571459	ENST00000468694	LITAF	chr16	11642974	-	DBNL	chr7	44085791	+
intron-intron	ENST00000571459	ENST00000490734	LITAF	chr16	11642974	-	DBNL	chr7	44085791	+
intron-intron	ENST00000571459	ENST00000494774	LITAF	chr16	11642974	-	DBNL	chr7	44085791	+
intron-intron	ENST00000571459	ENST00000497184	LITAF	chr16	11642974	-	DBNL	chr7	44085791	+
intron-intron	ENST00000571688	ENST00000440166	LITAF	chr16	11642974	-	DBNL	chr7	44085791	+
intron-intron	ENST00000571688	ENST00000448521	LITAF	chr16	11642974	-	DBNL	chr7	44085791	+
intron-intron	ENST00000571688	ENST00000452943	LITAF	chr16	11642974	-	DBNL	chr7	44085791	+
intron-intron	ENST00000571688	ENST00000456905	LITAF	chr16	11642974	-	DBNL	chr7	44085791	+
intron-intron	ENST00000571688	ENST00000468694	LITAF	chr16	11642974	-	DBNL	chr7	44085791	+
intron-intron	ENST00000571688	ENST00000490734	LITAF	chr16	11642974	-	DBNL	chr7	44085791	+
intron-intron	ENST00000571688	ENST00000494774	LITAF	chr16	11642974	-	DBNL	chr7	44085791	+
intron-intron	ENST00000571688	ENST00000497184	LITAF	chr16	11642974	-	DBNL	chr7	44085791	+
intron-intron	ENST00000571976	ENST00000440166	LITAF	chr16	11642974	-	DBNL	chr7	44085791	+
intron-intron	ENST00000571976	ENST00000448521	LITAF	chr16	11642974	-	DBNL	chr7	44085791	+
intron-intron	ENST00000571976	ENST00000452943	LITAF	chr16	11642974	-	DBNL	chr7	44085791	+
intron-intron	ENST00000571976	ENST00000456905	LITAF	chr16	11642974	-	DBNL	chr7	44085791	+
intron-intron	ENST00000571976	ENST00000468694	LITAF	chr16	11642974	-	DBNL	chr7	44085791	+
intron-intron	ENST00000571976	ENST00000490734	LITAF	chr16	11642974	-	DBNL	chr7	44085791	+
intron-intron	ENST00000571976	ENST00000494774	LITAF	chr16	11642974	-	DBNL	chr7	44085791	+
intron-intron	ENST00000571976	ENST00000497184	LITAF	chr16	11642974	-	DBNL	chr7	44085791	+
intron-intron	ENST00000572255	ENST00000440166	LITAF	chr16	11642974	-	DBNL	chr7	44085791	+
intron-intron	ENST00000572255	ENST00000448521	LITAF	chr16	11642974	-	DBNL	chr7	44085791	+
intron-intron	ENST00000572255	ENST00000452943	LITAF	chr16	11642974	-	DBNL	chr7	44085791	+
intron-intron	ENST00000572255	ENST00000456905	LITAF	chr16	11642974	-	DBNL	chr7	44085791	+
intron-intron	ENST00000572255	ENST00000468694	LITAF	chr16	11642974	-	DBNL	chr7	44085791	+
intron-intron	ENST00000572255	ENST00000490734	LITAF	chr16	11642974	-	DBNL	chr7	44085791	+
intron-intron	ENST00000572255	ENST00000494774	LITAF	chr16	11642974	-	DBNL	chr7	44085791	+
intron-intron	ENST00000572255	ENST00000497184	LITAF	chr16	11642974	-	DBNL	chr7	44085791	+
intron-intron	ENST00000574703	ENST00000440166	LITAF	chr16	11642974	-	DBNL	chr7	44085791	+
intron-intron	ENST00000574703	ENST00000448521	LITAF	chr16	11642974	-	DBNL	chr7	44085791	+
intron-intron	ENST00000574703	ENST00000452943	LITAF	chr16	11642974	-	DBNL	chr7	44085791	+
intron-intron	ENST00000574703	ENST00000456905	LITAF	chr16	11642974	-	DBNL	chr7	44085791	+
intron-intron	ENST00000574703	ENST00000468694	LITAF	chr16	11642974	-	DBNL	chr7	44085791	+
intron-intron	ENST00000574703	ENST00000490734	LITAF	chr16	11642974	-	DBNL	chr7	44085791	+
intron-intron	ENST00000574703	ENST00000494774	LITAF	chr16	11642974	-	DBNL	chr7	44085791	+
intron-intron	ENST00000574703	ENST00000497184	LITAF	chr16	11642974	-	DBNL	chr7	44085791	+
intron-intron	ENST00000574763	ENST00000440166	LITAF	chr16	11642974	-	DBNL	chr7	44085791	+
intron-intron	ENST00000574763	ENST00000448521	LITAF	chr16	11642974	-	DBNL	chr7	44085791	+
intron-intron	ENST00000574763	ENST00000452943	LITAF	chr16	11642974	-	DBNL	chr7	44085791	+
intron-intron	ENST00000574763	ENST00000456905	LITAF	chr16	11642974	-	DBNL	chr7	44085791	+
intron-intron	ENST00000574763	ENST00000468694	LITAF	chr16	11642974	-	DBNL	chr7	44085791	+
intron-intron	ENST00000574763	ENST00000490734	LITAF	chr16	11642974	-	DBNL	chr7	44085791	+
intron-intron	ENST00000574763	ENST00000494774	LITAF	chr16	11642974	-	DBNL	chr7	44085791	+
intron-intron	ENST00000574763	ENST00000497184	LITAF	chr16	11642974	-	DBNL	chr7	44085791	+
intron-intron	ENST00000576036	ENST00000440166	LITAF	chr16	11642974	-	DBNL	chr7	44085791	+
intron-intron	ENST00000576036	ENST00000448521	LITAF	chr16	11642974	-	DBNL	chr7	44085791	+
intron-intron	ENST00000576036	ENST00000452943	LITAF	chr16	11642974	-	DBNL	chr7	44085791	+
intron-intron	ENST00000576036	ENST00000456905	LITAF	chr16	11642974	-	DBNL	chr7	44085791	+
intron-intron	ENST00000576036	ENST00000468694	LITAF	chr16	11642974	-	DBNL	chr7	44085791	+
intron-intron	ENST00000576036	ENST00000490734	LITAF	chr16	11642974	-	DBNL	chr7	44085791	+
intron-intron	ENST00000576036	ENST00000494774	LITAF	chr16	11642974	-	DBNL	chr7	44085791	+
intron-intron	ENST00000576036	ENST00000497184	LITAF	chr16	11642974	-	DBNL	chr7	44085791	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

Top

Fusion Genomic Features for LITAF-DBNL

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for LITAF-DBNL

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:11642974/:44085791)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
LITAF Q99732	DBNL Q9UJU6
FUNCTION: Plays a role in endosomal protein trafficking and in targeting proteins for lysosomal degradation (PubMed:23166352). Plays a role in targeting endocytosed EGFR and ERGG3 for lysosomal degradation, and thereby helps downregulate downstream signaling cascades (PubMed:23166352). Helps recruit the ESCRT complex components TSG101, HGS and STAM to cytoplasmic membranes (PubMed:23166352). Probably plays a role in regulating protein degradation via its interaction with NEDD4 (PubMed:15776429). May also contribute to the regulation of gene expression in the nucleus (PubMed:10200294, PubMed:15793005). Binds DNA (in vitro) and may play a synergistic role with STAT6 in the nucleus in regulating the expression of various cytokines (PubMed:15793005). May regulate the expression of numerous cytokines, such as TNF, CCL2, CCL5, CXCL1, IL1A and IL10 (PubMed:10200294, PubMed:15793005). {ECO:0000269\|PubMed:15793005, ECO:0000269\|PubMed:23166352, ECO:0000303\|PubMed:15776429, ECO:0000305\|PubMed:10200294}.	FUNCTION: Adapter protein that binds F-actin and DNM1, and thereby plays a role in receptor-mediated endocytosis. Plays a role in the reorganization of the actin cytoskeleton, formation of cell projections, such as neurites, in neuron morphogenesis and synapse formation via its interaction with WASL and COBL. Does not bind G-actin and promote actin polymerization by itself. Required for the formation of organized podosome rosettes (By similarity). May act as a common effector of antigen receptor-signaling pathways in leukocytes. Acts as a key component of the immunological synapse that regulates T-cell activation by bridging TCRs and the actin cytoskeleton to gene activation and endocytic processes. {ECO:0000250, ECO:0000269\|PubMed:14729663}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Top

Fusion Gene Sequence for LITAF-DBNL

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

Top

Fusion Gene PPI Analysis for LITAF-DBNL

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for LITAF-DBNL

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for LITAF-DBNL

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source