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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:LLGL2-CDR2L (FusionGDB2 ID:45691) |
Fusion Gene Summary for LLGL2-CDR2L |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: LLGL2-CDR2L | Fusion gene ID: 45691 | Hgene | Tgene | Gene symbol | LLGL2 | CDR2L | Gene ID | 3993 | 30850 |
| Gene name | LLGL scribble cell polarity complex component 2 | cerebellar degeneration related protein 2 like | |
| Synonyms | HGL|Hugl-2|LGL2 | HUMPPA | |
| Cytomap | 17q25.1 | 17q25.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | LLGL scribble cell polarity complex component 2LLGL2, scribble cell polarity complex componenthuman giant larvae homologlethal giant larvae homolog 2, scribble cell polarity complex componentlethal(2) giant larvae protein homolog 2 | cerebellar degeneration-related protein 2-likeparaneoplastic 62 kDa antigenparaneoplastic antigen | |
| Modification date | 20200320 | 20200313 | |
| UniProtAcc | . | Q86X02 | |
| Ensembl transtripts involved in fusion gene | ENST00000375227, ENST00000167462, ENST00000392550, ENST00000577200, ENST00000578363, | ENST00000337231, | |
| Fusion gene scores | * DoF score | 17 X 14 X 10=2380 | 7 X 4 X 6=168 |
| # samples | 20 | 8 | |
| ** MAII score | log2(20/2380*10)=-3.57288966842058 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(8/168*10)=-1.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: LLGL2 [Title/Abstract] AND CDR2L [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | LLGL2(73560588)-CDR2L(72995599), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | LLGL2-CDR2L seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | LLGL2 | GO:0032878 | regulation of establishment or maintenance of cell polarity | 12725730 |
| Fusion gene breakpoints across LLGL2 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across CDR2L (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | SKCM | TCGA-FS-A1Z4-06A | LLGL2 | chr17 | 73560588 | + | CDR2L | chr17 | 72995599 | + |
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Fusion Gene ORF analysis for LLGL2-CDR2L |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000375227 | ENST00000337231 | LLGL2 | chr17 | 73560588 | + | CDR2L | chr17 | 72995599 | + |
| In-frame | ENST00000167462 | ENST00000337231 | LLGL2 | chr17 | 73560588 | + | CDR2L | chr17 | 72995599 | + |
| In-frame | ENST00000392550 | ENST00000337231 | LLGL2 | chr17 | 73560588 | + | CDR2L | chr17 | 72995599 | + |
| In-frame | ENST00000577200 | ENST00000337231 | LLGL2 | chr17 | 73560588 | + | CDR2L | chr17 | 72995599 | + |
| In-frame | ENST00000578363 | ENST00000337231 | LLGL2 | chr17 | 73560588 | + | CDR2L | chr17 | 72995599 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000167462 | LLGL2 | chr17 | 73560588 | + | ENST00000337231 | CDR2L | chr17 | 72995599 | + | 4211 | 1166 | 130 | 2484 | 784 |
| ENST00000392550 | LLGL2 | chr17 | 73560588 | + | ENST00000337231 | CDR2L | chr17 | 72995599 | + | 4198 | 1153 | 117 | 2471 | 784 |
| ENST00000578363 | LLGL2 | chr17 | 73560588 | + | ENST00000337231 | CDR2L | chr17 | 72995599 | + | 4283 | 1238 | 1159 | 2556 | 465 |
| ENST00000577200 | LLGL2 | chr17 | 73560588 | + | ENST00000337231 | CDR2L | chr17 | 72995599 | + | 4185 | 1140 | 62 | 2458 | 798 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000167462 | ENST00000337231 | LLGL2 | chr17 | 73560588 | + | CDR2L | chr17 | 72995599 | + | 0.011148176 | 0.98885185 |
| ENST00000392550 | ENST00000337231 | LLGL2 | chr17 | 73560588 | + | CDR2L | chr17 | 72995599 | + | 0.010918711 | 0.98908126 |
| ENST00000578363 | ENST00000337231 | LLGL2 | chr17 | 73560588 | + | CDR2L | chr17 | 72995599 | + | 0.0124905 | 0.98750955 |
| ENST00000577200 | ENST00000337231 | LLGL2 | chr17 | 73560588 | + | CDR2L | chr17 | 72995599 | + | 0.012011657 | 0.98798835 |
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Fusion Genomic Features for LLGL2-CDR2L |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| LLGL2 | chr17 | 73560588 | + | CDR2L | chr17 | 72995598 | + | 1.25E-11 | 1 |
| LLGL2 | chr17 | 73560588 | + | CDR2L | chr17 | 72995598 | + | 1.25E-11 | 1 |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for LLGL2-CDR2L |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:73560588/chr17:72995599) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | CDR2L |
| FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | LLGL2 | chr17:73560588 | chr17:72995599 | ENST00000167462 | + | 10 | 25 | 132_169 | 345 | 1016.0 | Repeat | Note=WD 3 |
| Hgene | LLGL2 | chr17:73560588 | chr17:72995599 | ENST00000167462 | + | 10 | 25 | 193_227 | 345 | 1016.0 | Repeat | Note=WD 4 |
| Hgene | LLGL2 | chr17:73560588 | chr17:72995599 | ENST00000167462 | + | 10 | 25 | 233_268 | 345 | 1016.0 | Repeat | Note=WD 5 |
| Hgene | LLGL2 | chr17:73560588 | chr17:72995599 | ENST00000167462 | + | 10 | 25 | 282_324 | 345 | 1016.0 | Repeat | Note=WD 6 |
| Hgene | LLGL2 | chr17:73560588 | chr17:72995599 | ENST00000167462 | + | 10 | 25 | 36_69 | 345 | 1016.0 | Repeat | Note=WD 1 |
| Hgene | LLGL2 | chr17:73560588 | chr17:72995599 | ENST00000167462 | + | 10 | 25 | 76_117 | 345 | 1016.0 | Repeat | Note=WD 2 |
| Hgene | LLGL2 | chr17:73560588 | chr17:72995599 | ENST00000392550 | + | 10 | 26 | 132_169 | 345 | 1021.0 | Repeat | Note=WD 3 |
| Hgene | LLGL2 | chr17:73560588 | chr17:72995599 | ENST00000392550 | + | 10 | 26 | 193_227 | 345 | 1021.0 | Repeat | Note=WD 4 |
| Hgene | LLGL2 | chr17:73560588 | chr17:72995599 | ENST00000392550 | + | 10 | 26 | 233_268 | 345 | 1021.0 | Repeat | Note=WD 5 |
| Hgene | LLGL2 | chr17:73560588 | chr17:72995599 | ENST00000392550 | + | 10 | 26 | 282_324 | 345 | 1021.0 | Repeat | Note=WD 6 |
| Hgene | LLGL2 | chr17:73560588 | chr17:72995599 | ENST00000392550 | + | 10 | 26 | 36_69 | 345 | 1021.0 | Repeat | Note=WD 1 |
| Hgene | LLGL2 | chr17:73560588 | chr17:72995599 | ENST00000392550 | + | 10 | 26 | 76_117 | 345 | 1021.0 | Repeat | Note=WD 2 |
| Tgene | CDR2L | chr17:73560588 | chr17:72995599 | ENST00000337231 | 0 | 5 | 188_265 | 26 | 466.0 | Coiled coil | Ontology_term=ECO:0000255 | |
| Tgene | CDR2L | chr17:73560588 | chr17:72995599 | ENST00000337231 | 0 | 5 | 350_377 | 26 | 466.0 | Coiled coil | Ontology_term=ECO:0000255 | |
| Tgene | CDR2L | chr17:73560588 | chr17:72995599 | ENST00000337231 | 0 | 5 | 38_143 | 26 | 466.0 | Coiled coil | Ontology_term=ECO:0000255 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | LLGL2 | chr17:73560588 | chr17:72995599 | ENST00000167462 | + | 10 | 25 | 332_366 | 345 | 1016.0 | Repeat | Note=WD 7 |
| Hgene | LLGL2 | chr17:73560588 | chr17:72995599 | ENST00000167462 | + | 10 | 25 | 388_464 | 345 | 1016.0 | Repeat | Note=WD 8 |
| Hgene | LLGL2 | chr17:73560588 | chr17:72995599 | ENST00000167462 | + | 10 | 25 | 508_583 | 345 | 1016.0 | Repeat | Note=WD 9 |
| Hgene | LLGL2 | chr17:73560588 | chr17:72995599 | ENST00000167462 | + | 10 | 25 | 592_653 | 345 | 1016.0 | Repeat | Note=WD 10 |
| Hgene | LLGL2 | chr17:73560588 | chr17:72995599 | ENST00000167462 | + | 10 | 25 | 713_769 | 345 | 1016.0 | Repeat | Note=WD 11 |
| Hgene | LLGL2 | chr17:73560588 | chr17:72995599 | ENST00000167462 | + | 10 | 25 | 778_830 | 345 | 1016.0 | Repeat | Note=WD 12 |
| Hgene | LLGL2 | chr17:73560588 | chr17:72995599 | ENST00000167462 | + | 10 | 25 | 835_888 | 345 | 1016.0 | Repeat | Note=WD 13 |
| Hgene | LLGL2 | chr17:73560588 | chr17:72995599 | ENST00000167462 | + | 10 | 25 | 902_925 | 345 | 1016.0 | Repeat | Note=WD 14 |
| Hgene | LLGL2 | chr17:73560588 | chr17:72995599 | ENST00000375227 | + | 1 | 10 | 132_169 | 0 | 357.0 | Repeat | Note=WD 3 |
| Hgene | LLGL2 | chr17:73560588 | chr17:72995599 | ENST00000375227 | + | 1 | 10 | 193_227 | 0 | 357.0 | Repeat | Note=WD 4 |
| Hgene | LLGL2 | chr17:73560588 | chr17:72995599 | ENST00000375227 | + | 1 | 10 | 233_268 | 0 | 357.0 | Repeat | Note=WD 5 |
| Hgene | LLGL2 | chr17:73560588 | chr17:72995599 | ENST00000375227 | + | 1 | 10 | 282_324 | 0 | 357.0 | Repeat | Note=WD 6 |
| Hgene | LLGL2 | chr17:73560588 | chr17:72995599 | ENST00000375227 | + | 1 | 10 | 332_366 | 0 | 357.0 | Repeat | Note=WD 7 |
| Hgene | LLGL2 | chr17:73560588 | chr17:72995599 | ENST00000375227 | + | 1 | 10 | 36_69 | 0 | 357.0 | Repeat | Note=WD 1 |
| Hgene | LLGL2 | chr17:73560588 | chr17:72995599 | ENST00000375227 | + | 1 | 10 | 388_464 | 0 | 357.0 | Repeat | Note=WD 8 |
| Hgene | LLGL2 | chr17:73560588 | chr17:72995599 | ENST00000375227 | + | 1 | 10 | 508_583 | 0 | 357.0 | Repeat | Note=WD 9 |
| Hgene | LLGL2 | chr17:73560588 | chr17:72995599 | ENST00000375227 | + | 1 | 10 | 592_653 | 0 | 357.0 | Repeat | Note=WD 10 |
| Hgene | LLGL2 | chr17:73560588 | chr17:72995599 | ENST00000375227 | + | 1 | 10 | 713_769 | 0 | 357.0 | Repeat | Note=WD 11 |
| Hgene | LLGL2 | chr17:73560588 | chr17:72995599 | ENST00000375227 | + | 1 | 10 | 76_117 | 0 | 357.0 | Repeat | Note=WD 2 |
| Hgene | LLGL2 | chr17:73560588 | chr17:72995599 | ENST00000375227 | + | 1 | 10 | 778_830 | 0 | 357.0 | Repeat | Note=WD 12 |
| Hgene | LLGL2 | chr17:73560588 | chr17:72995599 | ENST00000375227 | + | 1 | 10 | 835_888 | 0 | 357.0 | Repeat | Note=WD 13 |
| Hgene | LLGL2 | chr17:73560588 | chr17:72995599 | ENST00000375227 | + | 1 | 10 | 902_925 | 0 | 357.0 | Repeat | Note=WD 14 |
| Hgene | LLGL2 | chr17:73560588 | chr17:72995599 | ENST00000392550 | + | 10 | 26 | 332_366 | 345 | 1021.0 | Repeat | Note=WD 7 |
| Hgene | LLGL2 | chr17:73560588 | chr17:72995599 | ENST00000392550 | + | 10 | 26 | 388_464 | 345 | 1021.0 | Repeat | Note=WD 8 |
| Hgene | LLGL2 | chr17:73560588 | chr17:72995599 | ENST00000392550 | + | 10 | 26 | 508_583 | 345 | 1021.0 | Repeat | Note=WD 9 |
| Hgene | LLGL2 | chr17:73560588 | chr17:72995599 | ENST00000392550 | + | 10 | 26 | 592_653 | 345 | 1021.0 | Repeat | Note=WD 10 |
| Hgene | LLGL2 | chr17:73560588 | chr17:72995599 | ENST00000392550 | + | 10 | 26 | 713_769 | 345 | 1021.0 | Repeat | Note=WD 11 |
| Hgene | LLGL2 | chr17:73560588 | chr17:72995599 | ENST00000392550 | + | 10 | 26 | 778_830 | 345 | 1021.0 | Repeat | Note=WD 12 |
| Hgene | LLGL2 | chr17:73560588 | chr17:72995599 | ENST00000392550 | + | 10 | 26 | 835_888 | 345 | 1021.0 | Repeat | Note=WD 13 |
| Hgene | LLGL2 | chr17:73560588 | chr17:72995599 | ENST00000392550 | + | 10 | 26 | 902_925 | 345 | 1021.0 | Repeat | Note=WD 14 |
| Hgene | LLGL2 | chr17:73560588 | chr17:72995599 | ENST00000578363 | + | 1 | 11 | 132_169 | 0 | 357.0 | Repeat | Note=WD 3 |
| Hgene | LLGL2 | chr17:73560588 | chr17:72995599 | ENST00000578363 | + | 1 | 11 | 193_227 | 0 | 357.0 | Repeat | Note=WD 4 |
| Hgene | LLGL2 | chr17:73560588 | chr17:72995599 | ENST00000578363 | + | 1 | 11 | 233_268 | 0 | 357.0 | Repeat | Note=WD 5 |
| Hgene | LLGL2 | chr17:73560588 | chr17:72995599 | ENST00000578363 | + | 1 | 11 | 282_324 | 0 | 357.0 | Repeat | Note=WD 6 |
| Hgene | LLGL2 | chr17:73560588 | chr17:72995599 | ENST00000578363 | + | 1 | 11 | 332_366 | 0 | 357.0 | Repeat | Note=WD 7 |
| Hgene | LLGL2 | chr17:73560588 | chr17:72995599 | ENST00000578363 | + | 1 | 11 | 36_69 | 0 | 357.0 | Repeat | Note=WD 1 |
| Hgene | LLGL2 | chr17:73560588 | chr17:72995599 | ENST00000578363 | + | 1 | 11 | 388_464 | 0 | 357.0 | Repeat | Note=WD 8 |
| Hgene | LLGL2 | chr17:73560588 | chr17:72995599 | ENST00000578363 | + | 1 | 11 | 508_583 | 0 | 357.0 | Repeat | Note=WD 9 |
| Hgene | LLGL2 | chr17:73560588 | chr17:72995599 | ENST00000578363 | + | 1 | 11 | 592_653 | 0 | 357.0 | Repeat | Note=WD 10 |
| Hgene | LLGL2 | chr17:73560588 | chr17:72995599 | ENST00000578363 | + | 1 | 11 | 713_769 | 0 | 357.0 | Repeat | Note=WD 11 |
| Hgene | LLGL2 | chr17:73560588 | chr17:72995599 | ENST00000578363 | + | 1 | 11 | 76_117 | 0 | 357.0 | Repeat | Note=WD 2 |
| Hgene | LLGL2 | chr17:73560588 | chr17:72995599 | ENST00000578363 | + | 1 | 11 | 778_830 | 0 | 357.0 | Repeat | Note=WD 12 |
| Hgene | LLGL2 | chr17:73560588 | chr17:72995599 | ENST00000578363 | + | 1 | 11 | 835_888 | 0 | 357.0 | Repeat | Note=WD 13 |
| Hgene | LLGL2 | chr17:73560588 | chr17:72995599 | ENST00000578363 | + | 1 | 11 | 902_925 | 0 | 357.0 | Repeat | Note=WD 14 |
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Fusion Gene Sequence for LLGL2-CDR2L |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >45691_45691_1_LLGL2-CDR2L_LLGL2_chr17_73560588_ENST00000167462_CDR2L_chr17_72995599_ENST00000337231_length(transcript)=4211nt_BP=1166nt CGCCCAGCAGCCCGTGGGCAGGCGCGGCGGAGCGAGCGGGGCCGGCGGCGGGCGCCGAGGGACGCCGAGGCCTCGGGCGGGGGCTGGCCC GGGGTTCCAGGTCTCCAGTGGGGGCTGCAGACTAAGCAAAATGAGGCGGTTCCTGAGGCCAGGGCATGACCCTGTGCGGGAGAGGCTCAA GCGGGACCTGTTCCAGTTTAACAAGACGGTGGAGCATGGCTTCCCGCACCAGCCCAGCGCCCTCGGCTACAGCCCGTCCCTGCGCATCCT GGCCATCGGCACCCGTTCTGGAGCCATCAAGCTCTACGGAGCCCCAGGCGTGGAGTTCATGGGGCTGCACCAGGAGAACAACGCTGTGAC GCAGATCCACCTCCTGCCCGGCCAGTGCCAGCTGGTCACCCTGCTGGATGACAACAGCCTGCACCTTTGGAGCCTGAAGGTCAAGGGCGG GGCATCGGAGCTGCAGGAGGATGAGAGCTTCACACTGCGTGGACCCCCAGGGGCTGCCCCCAGTGCCACACAGATCACCGTGGTCCTGCC ACATTCCTCCTGCGAGCTGCTCTACCTGGGCACCGAGAGTGGCAACGTGTTTGTGGTGCAGCTGCCAGCTTTTCGTGCGCTGGAGGACCG GACCATCAGCTCGGACGCGGTGCTGCAGCGGTTGCCAGAGGAGGCCCGCCACCGGCGTGTGTTCGAGATGGTGGAGGCACTGCAGGAGCA CCCTCGAGACCCCAACCAGATCCTGATCGGCTACAGCCGAGGCCTCGTTGTCATCTGGGACCTACAGGGCAGCCGCGTGCTCTACCACTT CCTCAGCAGCCAGCAACTGGAGAACATCTGGTGGCAGCGGGACGGCCGCCTGCTCGTCAGCTGTCACTCTGACGGCAGCTACTGCCAGTG GCCCGTGTCCAGCGAAGCCCAGCAACCAGAGCCCCTCCGCAGCCTCGTGCCTTACGGTCCCTTTCCTTGCAAAGCGATTACCAGAATCCT CTGGCTGACCACTAGGCAGGGGTTGCCCTTCACCATCTTCCAGGGTGGCATGCCACGGGCCAGCTACGGGGACCGCCACTGCATCTCAGT GATCCACGATGGCCAGCAGACGGCCTTCGACTTCACCTCCCGTGTCATCGGCTTCACTGTCCTCACAGAGGCAGACCCTGCAGCCAACTT GCACCTAGCTGCGGAGCTGGGGAAGACTCTGCTGGAGAGGAACAAGGAGCTGGAGGGGTCCCTGCAGCAGATGTACTCCACCAATGAGGA ACAGGTGCAGGAGATCGAGTACCTAACCAAGCAGCTGGACACGCTGCGGCACGTGAACGAGCAGCACGCCAAAGTCTATGAGCAGCTGGA CCTGACAGCCCGGGACCTGGAGCTGACCAACCACAGGCTGGTGCTGGAGAGTAAGGCTGCCCAGCAGAAGATCCATGGGCTGACGGAGAC CATTGAGCGCCTCCAGGCTCAGGTGGAGGAGCTGCAGGCCCAGGTGGAGCAACTGAGAGGCCTGGAACAGCTGCGAGTGCTCCGGGAGAA GCGGGAACGCAGGCGTACCATCCACACCTTCCCCTGCCTCAAGGAGCTGTGCACCAGCCCCCGGTGCAAGGATGCTTTCCGCCTACACAG TTCCTCCCTGGAGCTGGGCCCGCGGCCCCTGGAGCAGGAGAACGAGCGGCTGCAGACCCTGGTGGGGGCGCTGCGCTCCCAGGTGAGCCA GGAGCGGCAGCGCAAGGAGCGGGCGGAGCGCGAGTACACCGCGGTGCTGCAGGAGTACTCGGAGCTGGAGCGCCAGCTGTGCGAGATGGA GGCCTGTCGCCTGCGTGTGCAGGAGCTGGAGGCCGAGCTGCTGGAGCTGCAGCAGATGAAGCAGGCCAAGACCTACCTACTGGGTCCGGA CGACCACCTGGCCGAGGCCCTGCTCGCACCCCTCACGCAGGCCCCTGAGGCCGACGATCCCCAGCCCGGCCGCGGGGACGACTTGGGCGC CCAGGACGGGGTCTCCTCACCGGCAGCCTCTCCAGGCCACGTGGTGCGCAAGAGCTGCAGCGACACTGCGCTCAACGCCATCGTGGCCAA AGACCCAGCCAGCCGGCACGCGGGCAACCTCACACTGCACGCCAACAGCGTGCGCAAGCGGGGCATGTCCATCCTGCGGGAGGTGGACGA GCAGTACCACGCGCTGCTGGAGAAGTACGAGGAGCTGCTGAGCAAGTGCCGGCAGCACGGGGCCGGAGTGCGGCACGCCGGCGTGCAGAC CTCGCGCCCCATCTCCCGGGACAGCTCGTGGAGGGACCTGCGCGGGGGTGAGGAGGGCCAGGGTGAGGTCAAGGCAGGAGAGAAGAGCCT GAGCCAGCACGTGGAGGCCGTGGACAAGCGGCTGGAACAGAGCCAGCCCGAGTACAAGGCGCTCTTCAAAGAGATCTTCTCCAGGATCCA GAAGACCAAGGCTGACATCAACGCCACCAAAGTCAAGACGCACAGCAGCAAGTGACCCTTCTCCGGCCTGCAGCCTCCCCCAGGGTGGAA GCCGTGGGGTCCCTCAGGCCTGGGCGGTGCAGCTTCCAGAGAGCGAGCGCCCTTTAGCGGCCTGCCACCACAGCACGCGGCCTCCTGATC CGGAAGCACGCAGCATGTTCCCTGCTGAGCGGAGGCAGCCCACCTGTCCTGCCTCCCAGGAGCCCTTGGCCACCTCGCGCCAGCCCAAAG GCGCAGCTCTGAGTTCAAAGCCAAATGTCCCCACTACCCCAGGGATCCCCCAGCTCCCCCAGCCCCTGGCTTCCTGACCCTGCGCCTCAC CCTCAGACTGGTGACCAGGCTTCTGAAAGCCATTCTGGATCAGTTGGCTTTTTTTTTTTTTTTGGTTAAGTTTGTTTTTTCTAAGAGATT TGCAATGCAAGGTCTCCTTGACCCCTTGCCACAACTGGAAACACTTGAAAGGGGACCCCAGGGCCAGCTGTTTCAGGGGTTTCCTGGACC ACCCACTGCTTCTCCCCAACCCTGATGCGCTGACATTCCCTTAGCACCAGCTGTCCCACCTCCAGGGTCCTGACCAGGTCAGAGATGTCC CCTGCCATGCAGAGCAGGAAGCCTCAGCTGGGCCTGGAGTGTCCCTGCTCCAGCCCTGCCAGGGACAGGTTTCTCCCTGGATACTCTTGG CCCACCGCAGATCTGTAGCCAGTCAGAGGAGGAGGAGAAGGAGCCCCTCAGCAGAGTGGTGCAGTTTCGCTCAGAGCTTGTCTCCTTGGC TTCCAACCCCAGAAATGCCTGCTGGGCCTTAAGCTTTCCAGGGGCCGGGGCAGTGGGGAGCCCCCATCCCTTCACACCGCCACCAACTAA CCAAGCTTGGCCTCTGACTCCCGTCTCTGTGCTTGCCCCCATCTCAGGGACCATGATGTCTCAGTCACTCCACGCTCCCCACAGGCCAAC CCTGGCACAGGTCATGTCTGCAGCCCCCAGAATGTTCTGGACATGCACCACCAGCCGGTGGTCCCAATGTCCACCCCTGCCTCCCCTTCA CTGGGGACTGGGGTTTTCGCCCCATGCTGCATCGTGTTGTATTGGGATGGGGCTGAGGAACATGCTCCCTCCCTCCCTCCCATAAAATGC CTGCTCTTCACCTCCCACCTTTGTGGGGGGCTTTTGAGGACCCAGCTGCGTCAGGAGTTTTGCTTCAAGATGTCAGAAAGTCAAGTTCAG CTAAGAGACACCCAGGTCCCCAGCTTGCCCTGAGCAGCCCTTCAGGGCTTCTGGTTCCTTCTGCCGCCCTTCCTGAGACCTTAGAAACCA GAAGAGCCATACAGTCAGTGGAAGGCGGGGGGGCCCTGGCCTCTGCACCGGGATCCCAGTGGGAACCTTCATGCCTTATTTATTTCTAAT GGGTAAAGGGGTTTTCTTACCAAGCATCCCTGACCTCCTGGAGACACCACCTGCTTTCCGGGCGGCACTGTGATGGGAGCTGGTGGCGAC TGAGTCCTTCTGTACGTGCAACTGGGAAACTTTTGTCCTTTGAGGCTAGGCAGCTCCCTGCCCTCCGTGTGTGTCTGTTATCTGGGGGAG AGGAGTGTGGAAGGGTTGGGGGAAGAGCTCCAGCCTGTCTGCTCCCCAGCTCTGTAGTGGCAGACCAGCGTCACCTTTGAAGTATACGTG >45691_45691_1_LLGL2-CDR2L_LLGL2_chr17_73560588_ENST00000167462_CDR2L_chr17_72995599_ENST00000337231_length(amino acids)=784AA_BP=346 MRRFLRPGHDPVRERLKRDLFQFNKTVEHGFPHQPSALGYSPSLRILAIGTRSGAIKLYGAPGVEFMGLHQENNAVTQIHLLPGQCQLVT LLDDNSLHLWSLKVKGGASELQEDESFTLRGPPGAAPSATQITVVLPHSSCELLYLGTESGNVFVVQLPAFRALEDRTISSDAVLQRLPE EARHRRVFEMVEALQEHPRDPNQILIGYSRGLVVIWDLQGSRVLYHFLSSQQLENIWWQRDGRLLVSCHSDGSYCQWPVSSEAQQPEPLR SLVPYGPFPCKAITRILWLTTRQGLPFTIFQGGMPRASYGDRHCISVIHDGQQTAFDFTSRVIGFTVLTEADPAANLHLAAELGKTLLER NKELEGSLQQMYSTNEEQVQEIEYLTKQLDTLRHVNEQHAKVYEQLDLTARDLELTNHRLVLESKAAQQKIHGLTETIERLQAQVEELQA QVEQLRGLEQLRVLREKRERRRTIHTFPCLKELCTSPRCKDAFRLHSSSLELGPRPLEQENERLQTLVGALRSQVSQERQRKERAEREYT AVLQEYSELERQLCEMEACRLRVQELEAELLELQQMKQAKTYLLGPDDHLAEALLAPLTQAPEADDPQPGRGDDLGAQDGVSSPAASPGH VVRKSCSDTALNAIVAKDPASRHAGNLTLHANSVRKRGMSILREVDEQYHALLEKYEELLSKCRQHGAGVRHAGVQTSRPISRDSSWRDL -------------------------------------------------------------- >45691_45691_2_LLGL2-CDR2L_LLGL2_chr17_73560588_ENST00000392550_CDR2L_chr17_72995599_ENST00000337231_length(transcript)=4198nt_BP=1153nt GTGGGCAGGCGCGGCGGAGCGAGCGGGGCCGGCGGCGGGCGCCGAGGGACGCCGAGGCCTCGGGCGGGGGCTGGCCCGGGGTTCCAGGTC TCCAGTGGGGGCTGCAGACTAAGCAAAATGAGGCGGTTCCTGAGGCCAGGGCATGACCCTGTGCGGGAGAGGCTCAAGCGGGACCTGTTC CAGTTTAACAAGACGGTGGAGCATGGCTTCCCGCACCAGCCCAGCGCCCTCGGCTACAGCCCGTCCCTGCGCATCCTGGCCATCGGCACC CGTTCTGGAGCCATCAAGCTCTACGGAGCCCCAGGCGTGGAGTTCATGGGGCTGCACCAGGAGAACAACGCTGTGACGCAGATCCACCTC CTGCCCGGCCAGTGCCAGCTGGTCACCCTGCTGGATGACAACAGCCTGCACCTTTGGAGCCTGAAGGTCAAGGGCGGGGCATCGGAGCTG CAGGAGGATGAGAGCTTCACACTGCGTGGACCCCCAGGGGCTGCCCCCAGTGCCACACAGATCACCGTGGTCCTGCCACATTCCTCCTGC GAGCTGCTCTACCTGGGCACCGAGAGTGGCAACGTGTTTGTGGTGCAGCTGCCAGCTTTTCGTGCGCTGGAGGACCGGACCATCAGCTCG GACGCGGTGCTGCAGCGGTTGCCAGAGGAGGCCCGCCACCGGCGTGTGTTCGAGATGGTGGAGGCACTGCAGGAGCACCCTCGAGACCCC AACCAGATCCTGATCGGCTACAGCCGAGGCCTCGTTGTCATCTGGGACCTACAGGGCAGCCGCGTGCTCTACCACTTCCTCAGCAGCCAG CAACTGGAGAACATCTGGTGGCAGCGGGACGGCCGCCTGCTCGTCAGCTGTCACTCTGACGGCAGCTACTGCCAGTGGCCCGTGTCCAGC GAAGCCCAGCAACCAGAGCCCCTCCGCAGCCTCGTGCCTTACGGTCCCTTTCCTTGCAAAGCGATTACCAGAATCCTCTGGCTGACCACT AGGCAGGGGTTGCCCTTCACCATCTTCCAGGGTGGCATGCCACGGGCCAGCTACGGGGACCGCCACTGCATCTCAGTGATCCACGATGGC CAGCAGACGGCCTTCGACTTCACCTCCCGTGTCATCGGCTTCACTGTCCTCACAGAGGCAGACCCTGCAGCCAACTTGCACCTAGCTGCG GAGCTGGGGAAGACTCTGCTGGAGAGGAACAAGGAGCTGGAGGGGTCCCTGCAGCAGATGTACTCCACCAATGAGGAACAGGTGCAGGAG ATCGAGTACCTAACCAAGCAGCTGGACACGCTGCGGCACGTGAACGAGCAGCACGCCAAAGTCTATGAGCAGCTGGACCTGACAGCCCGG GACCTGGAGCTGACCAACCACAGGCTGGTGCTGGAGAGTAAGGCTGCCCAGCAGAAGATCCATGGGCTGACGGAGACCATTGAGCGCCTC CAGGCTCAGGTGGAGGAGCTGCAGGCCCAGGTGGAGCAACTGAGAGGCCTGGAACAGCTGCGAGTGCTCCGGGAGAAGCGGGAACGCAGG CGTACCATCCACACCTTCCCCTGCCTCAAGGAGCTGTGCACCAGCCCCCGGTGCAAGGATGCTTTCCGCCTACACAGTTCCTCCCTGGAG CTGGGCCCGCGGCCCCTGGAGCAGGAGAACGAGCGGCTGCAGACCCTGGTGGGGGCGCTGCGCTCCCAGGTGAGCCAGGAGCGGCAGCGC AAGGAGCGGGCGGAGCGCGAGTACACCGCGGTGCTGCAGGAGTACTCGGAGCTGGAGCGCCAGCTGTGCGAGATGGAGGCCTGTCGCCTG CGTGTGCAGGAGCTGGAGGCCGAGCTGCTGGAGCTGCAGCAGATGAAGCAGGCCAAGACCTACCTACTGGGTCCGGACGACCACCTGGCC GAGGCCCTGCTCGCACCCCTCACGCAGGCCCCTGAGGCCGACGATCCCCAGCCCGGCCGCGGGGACGACTTGGGCGCCCAGGACGGGGTC TCCTCACCGGCAGCCTCTCCAGGCCACGTGGTGCGCAAGAGCTGCAGCGACACTGCGCTCAACGCCATCGTGGCCAAAGACCCAGCCAGC CGGCACGCGGGCAACCTCACACTGCACGCCAACAGCGTGCGCAAGCGGGGCATGTCCATCCTGCGGGAGGTGGACGAGCAGTACCACGCG CTGCTGGAGAAGTACGAGGAGCTGCTGAGCAAGTGCCGGCAGCACGGGGCCGGAGTGCGGCACGCCGGCGTGCAGACCTCGCGCCCCATC TCCCGGGACAGCTCGTGGAGGGACCTGCGCGGGGGTGAGGAGGGCCAGGGTGAGGTCAAGGCAGGAGAGAAGAGCCTGAGCCAGCACGTG GAGGCCGTGGACAAGCGGCTGGAACAGAGCCAGCCCGAGTACAAGGCGCTCTTCAAAGAGATCTTCTCCAGGATCCAGAAGACCAAGGCT GACATCAACGCCACCAAAGTCAAGACGCACAGCAGCAAGTGACCCTTCTCCGGCCTGCAGCCTCCCCCAGGGTGGAAGCCGTGGGGTCCC TCAGGCCTGGGCGGTGCAGCTTCCAGAGAGCGAGCGCCCTTTAGCGGCCTGCCACCACAGCACGCGGCCTCCTGATCCGGAAGCACGCAG CATGTTCCCTGCTGAGCGGAGGCAGCCCACCTGTCCTGCCTCCCAGGAGCCCTTGGCCACCTCGCGCCAGCCCAAAGGCGCAGCTCTGAG TTCAAAGCCAAATGTCCCCACTACCCCAGGGATCCCCCAGCTCCCCCAGCCCCTGGCTTCCTGACCCTGCGCCTCACCCTCAGACTGGTG ACCAGGCTTCTGAAAGCCATTCTGGATCAGTTGGCTTTTTTTTTTTTTTTGGTTAAGTTTGTTTTTTCTAAGAGATTTGCAATGCAAGGT CTCCTTGACCCCTTGCCACAACTGGAAACACTTGAAAGGGGACCCCAGGGCCAGCTGTTTCAGGGGTTTCCTGGACCACCCACTGCTTCT CCCCAACCCTGATGCGCTGACATTCCCTTAGCACCAGCTGTCCCACCTCCAGGGTCCTGACCAGGTCAGAGATGTCCCCTGCCATGCAGA GCAGGAAGCCTCAGCTGGGCCTGGAGTGTCCCTGCTCCAGCCCTGCCAGGGACAGGTTTCTCCCTGGATACTCTTGGCCCACCGCAGATC TGTAGCCAGTCAGAGGAGGAGGAGAAGGAGCCCCTCAGCAGAGTGGTGCAGTTTCGCTCAGAGCTTGTCTCCTTGGCTTCCAACCCCAGA AATGCCTGCTGGGCCTTAAGCTTTCCAGGGGCCGGGGCAGTGGGGAGCCCCCATCCCTTCACACCGCCACCAACTAACCAAGCTTGGCCT CTGACTCCCGTCTCTGTGCTTGCCCCCATCTCAGGGACCATGATGTCTCAGTCACTCCACGCTCCCCACAGGCCAACCCTGGCACAGGTC ATGTCTGCAGCCCCCAGAATGTTCTGGACATGCACCACCAGCCGGTGGTCCCAATGTCCACCCCTGCCTCCCCTTCACTGGGGACTGGGG TTTTCGCCCCATGCTGCATCGTGTTGTATTGGGATGGGGCTGAGGAACATGCTCCCTCCCTCCCTCCCATAAAATGCCTGCTCTTCACCT CCCACCTTTGTGGGGGGCTTTTGAGGACCCAGCTGCGTCAGGAGTTTTGCTTCAAGATGTCAGAAAGTCAAGTTCAGCTAAGAGACACCC AGGTCCCCAGCTTGCCCTGAGCAGCCCTTCAGGGCTTCTGGTTCCTTCTGCCGCCCTTCCTGAGACCTTAGAAACCAGAAGAGCCATACA GTCAGTGGAAGGCGGGGGGGCCCTGGCCTCTGCACCGGGATCCCAGTGGGAACCTTCATGCCTTATTTATTTCTAATGGGTAAAGGGGTT TTCTTACCAAGCATCCCTGACCTCCTGGAGACACCACCTGCTTTCCGGGCGGCACTGTGATGGGAGCTGGTGGCGACTGAGTCCTTCTGT ACGTGCAACTGGGAAACTTTTGTCCTTTGAGGCTAGGCAGCTCCCTGCCCTCCGTGTGTGTCTGTTATCTGGGGGAGAGGAGTGTGGAAG GGTTGGGGGAAGAGCTCCAGCCTGTCTGCTCCCCAGCTCTGTAGTGGCAGACCAGCGTCACCTTTGAAGTATACGTGAGAGAAATATATT >45691_45691_2_LLGL2-CDR2L_LLGL2_chr17_73560588_ENST00000392550_CDR2L_chr17_72995599_ENST00000337231_length(amino acids)=784AA_BP=346 MRRFLRPGHDPVRERLKRDLFQFNKTVEHGFPHQPSALGYSPSLRILAIGTRSGAIKLYGAPGVEFMGLHQENNAVTQIHLLPGQCQLVT LLDDNSLHLWSLKVKGGASELQEDESFTLRGPPGAAPSATQITVVLPHSSCELLYLGTESGNVFVVQLPAFRALEDRTISSDAVLQRLPE EARHRRVFEMVEALQEHPRDPNQILIGYSRGLVVIWDLQGSRVLYHFLSSQQLENIWWQRDGRLLVSCHSDGSYCQWPVSSEAQQPEPLR SLVPYGPFPCKAITRILWLTTRQGLPFTIFQGGMPRASYGDRHCISVIHDGQQTAFDFTSRVIGFTVLTEADPAANLHLAAELGKTLLER NKELEGSLQQMYSTNEEQVQEIEYLTKQLDTLRHVNEQHAKVYEQLDLTARDLELTNHRLVLESKAAQQKIHGLTETIERLQAQVEELQA QVEQLRGLEQLRVLREKRERRRTIHTFPCLKELCTSPRCKDAFRLHSSSLELGPRPLEQENERLQTLVGALRSQVSQERQRKERAEREYT AVLQEYSELERQLCEMEACRLRVQELEAELLELQQMKQAKTYLLGPDDHLAEALLAPLTQAPEADDPQPGRGDDLGAQDGVSSPAASPGH VVRKSCSDTALNAIVAKDPASRHAGNLTLHANSVRKRGMSILREVDEQYHALLEKYEELLSKCRQHGAGVRHAGVQTSRPISRDSSWRDL -------------------------------------------------------------- >45691_45691_3_LLGL2-CDR2L_LLGL2_chr17_73560588_ENST00000577200_CDR2L_chr17_72995599_ENST00000337231_length(transcript)=4185nt_BP=1140nt GGCTCACTGCAACCTCTGCCTCCCGGGTTCAAGCAATTCTCCTGCCTCGGCCTCCTGAGTAGCTGGGATTACAGGTCTCCAGTGGGGGCT GCAGACTAAGCAAAATGAGGCGGTTCCTGAGGCCAGGGCATGACCCTGTGCGGGAGAGGCTCAAGCGGGACCTGTTCCAGTTTAACAAGA CGGTGGAGCATGGCTTCCCGCACCAGCCCAGCGCCCTCGGCTACAGCCCGTCCCTGCGCATCCTGGCCATCGGCACCCGTTCTGGAGCCA TCAAGCTCTACGGAGCCCCAGGCGTGGAGTTCATGGGGCTGCACCAGGAGAACAACGCTGTGACGCAGATCCACCTCCTGCCCGGCCAGT GCCAGCTGGTCACCCTGCTGGATGACAACAGCCTGCACCTTTGGAGCCTGAAGGTCAAGGGCGGGGCATCGGAGCTGCAGGAGGATGAGA GCTTCACACTGCGTGGACCCCCAGGGGCTGCCCCCAGTGCCACACAGATCACCGTGGTCCTGCCACATTCCTCCTGCGAGCTGCTCTACC TGGGCACCGAGAGTGGCAACGTGTTTGTGGTGCAGCTGCCAGCTTTTCGTGCGCTGGAGGACCGGACCATCAGCTCGGACGCGGTGCTGC AGCGGTTGCCAGAGGAGGCCCGCCACCGGCGTGTGTTCGAGATGGTGGAGGCACTGCAGGAGCACCCTCGAGACCCCAACCAGATCCTGA TCGGCTACAGCCGAGGCCTCGTTGTCATCTGGGACCTACAGGGCAGCCGCGTGCTCTACCACTTCCTCAGCAGCCAGCAACTGGAGAACA TCTGGTGGCAGCGGGACGGCCGCCTGCTCGTCAGCTGTCACTCTGACGGCAGCTACTGCCAGTGGCCCGTGTCCAGCGAAGCCCAGCAAC CAGAGCCCCTCCGCAGCCTCGTGCCTTACGGTCCCTTTCCTTGCAAAGCGATTACCAGAATCCTCTGGCTGACCACTAGGCAGGGGTTGC CCTTCACCATCTTCCAGGGTGGCATGCCACGGGCCAGCTACGGGGACCGCCACTGCATCTCAGTGATCCACGATGGCCAGCAGACGGCCT TCGACTTCACCTCCCGTGTCATCGGCTTCACTGTCCTCACAGAGGCAGACCCTGCAGCCAACTTGCACCTAGCTGCGGAGCTGGGGAAGA CTCTGCTGGAGAGGAACAAGGAGCTGGAGGGGTCCCTGCAGCAGATGTACTCCACCAATGAGGAACAGGTGCAGGAGATCGAGTACCTAA CCAAGCAGCTGGACACGCTGCGGCACGTGAACGAGCAGCACGCCAAAGTCTATGAGCAGCTGGACCTGACAGCCCGGGACCTGGAGCTGA CCAACCACAGGCTGGTGCTGGAGAGTAAGGCTGCCCAGCAGAAGATCCATGGGCTGACGGAGACCATTGAGCGCCTCCAGGCTCAGGTGG AGGAGCTGCAGGCCCAGGTGGAGCAACTGAGAGGCCTGGAACAGCTGCGAGTGCTCCGGGAGAAGCGGGAACGCAGGCGTACCATCCACA CCTTCCCCTGCCTCAAGGAGCTGTGCACCAGCCCCCGGTGCAAGGATGCTTTCCGCCTACACAGTTCCTCCCTGGAGCTGGGCCCGCGGC CCCTGGAGCAGGAGAACGAGCGGCTGCAGACCCTGGTGGGGGCGCTGCGCTCCCAGGTGAGCCAGGAGCGGCAGCGCAAGGAGCGGGCGG AGCGCGAGTACACCGCGGTGCTGCAGGAGTACTCGGAGCTGGAGCGCCAGCTGTGCGAGATGGAGGCCTGTCGCCTGCGTGTGCAGGAGC TGGAGGCCGAGCTGCTGGAGCTGCAGCAGATGAAGCAGGCCAAGACCTACCTACTGGGTCCGGACGACCACCTGGCCGAGGCCCTGCTCG CACCCCTCACGCAGGCCCCTGAGGCCGACGATCCCCAGCCCGGCCGCGGGGACGACTTGGGCGCCCAGGACGGGGTCTCCTCACCGGCAG CCTCTCCAGGCCACGTGGTGCGCAAGAGCTGCAGCGACACTGCGCTCAACGCCATCGTGGCCAAAGACCCAGCCAGCCGGCACGCGGGCA ACCTCACACTGCACGCCAACAGCGTGCGCAAGCGGGGCATGTCCATCCTGCGGGAGGTGGACGAGCAGTACCACGCGCTGCTGGAGAAGT ACGAGGAGCTGCTGAGCAAGTGCCGGCAGCACGGGGCCGGAGTGCGGCACGCCGGCGTGCAGACCTCGCGCCCCATCTCCCGGGACAGCT CGTGGAGGGACCTGCGCGGGGGTGAGGAGGGCCAGGGTGAGGTCAAGGCAGGAGAGAAGAGCCTGAGCCAGCACGTGGAGGCCGTGGACA AGCGGCTGGAACAGAGCCAGCCCGAGTACAAGGCGCTCTTCAAAGAGATCTTCTCCAGGATCCAGAAGACCAAGGCTGACATCAACGCCA CCAAAGTCAAGACGCACAGCAGCAAGTGACCCTTCTCCGGCCTGCAGCCTCCCCCAGGGTGGAAGCCGTGGGGTCCCTCAGGCCTGGGCG GTGCAGCTTCCAGAGAGCGAGCGCCCTTTAGCGGCCTGCCACCACAGCACGCGGCCTCCTGATCCGGAAGCACGCAGCATGTTCCCTGCT GAGCGGAGGCAGCCCACCTGTCCTGCCTCCCAGGAGCCCTTGGCCACCTCGCGCCAGCCCAAAGGCGCAGCTCTGAGTTCAAAGCCAAAT GTCCCCACTACCCCAGGGATCCCCCAGCTCCCCCAGCCCCTGGCTTCCTGACCCTGCGCCTCACCCTCAGACTGGTGACCAGGCTTCTGA AAGCCATTCTGGATCAGTTGGCTTTTTTTTTTTTTTTGGTTAAGTTTGTTTTTTCTAAGAGATTTGCAATGCAAGGTCTCCTTGACCCCT TGCCACAACTGGAAACACTTGAAAGGGGACCCCAGGGCCAGCTGTTTCAGGGGTTTCCTGGACCACCCACTGCTTCTCCCCAACCCTGAT GCGCTGACATTCCCTTAGCACCAGCTGTCCCACCTCCAGGGTCCTGACCAGGTCAGAGATGTCCCCTGCCATGCAGAGCAGGAAGCCTCA GCTGGGCCTGGAGTGTCCCTGCTCCAGCCCTGCCAGGGACAGGTTTCTCCCTGGATACTCTTGGCCCACCGCAGATCTGTAGCCAGTCAG AGGAGGAGGAGAAGGAGCCCCTCAGCAGAGTGGTGCAGTTTCGCTCAGAGCTTGTCTCCTTGGCTTCCAACCCCAGAAATGCCTGCTGGG CCTTAAGCTTTCCAGGGGCCGGGGCAGTGGGGAGCCCCCATCCCTTCACACCGCCACCAACTAACCAAGCTTGGCCTCTGACTCCCGTCT CTGTGCTTGCCCCCATCTCAGGGACCATGATGTCTCAGTCACTCCACGCTCCCCACAGGCCAACCCTGGCACAGGTCATGTCTGCAGCCC CCAGAATGTTCTGGACATGCACCACCAGCCGGTGGTCCCAATGTCCACCCCTGCCTCCCCTTCACTGGGGACTGGGGTTTTCGCCCCATG CTGCATCGTGTTGTATTGGGATGGGGCTGAGGAACATGCTCCCTCCCTCCCTCCCATAAAATGCCTGCTCTTCACCTCCCACCTTTGTGG GGGGCTTTTGAGGACCCAGCTGCGTCAGGAGTTTTGCTTCAAGATGTCAGAAAGTCAAGTTCAGCTAAGAGACACCCAGGTCCCCAGCTT GCCCTGAGCAGCCCTTCAGGGCTTCTGGTTCCTTCTGCCGCCCTTCCTGAGACCTTAGAAACCAGAAGAGCCATACAGTCAGTGGAAGGC GGGGGGGCCCTGGCCTCTGCACCGGGATCCCAGTGGGAACCTTCATGCCTTATTTATTTCTAATGGGTAAAGGGGTTTTCTTACCAAGCA TCCCTGACCTCCTGGAGACACCACCTGCTTTCCGGGCGGCACTGTGATGGGAGCTGGTGGCGACTGAGTCCTTCTGTACGTGCAACTGGG AAACTTTTGTCCTTTGAGGCTAGGCAGCTCCCTGCCCTCCGTGTGTGTCTGTTATCTGGGGGAGAGGAGTGTGGAAGGGTTGGGGGAAGA GCTCCAGCCTGTCTGCTCCCCAGCTCTGTAGTGGCAGACCAGCGTCACCTTTGAAGTATACGTGAGAGAAATATATTTACAAATGCTTTA >45691_45691_3_LLGL2-CDR2L_LLGL2_chr17_73560588_ENST00000577200_CDR2L_chr17_72995599_ENST00000337231_length(amino acids)=798AA_BP=360 MGLQVSSGGCRLSKMRRFLRPGHDPVRERLKRDLFQFNKTVEHGFPHQPSALGYSPSLRILAIGTRSGAIKLYGAPGVEFMGLHQENNAV TQIHLLPGQCQLVTLLDDNSLHLWSLKVKGGASELQEDESFTLRGPPGAAPSATQITVVLPHSSCELLYLGTESGNVFVVQLPAFRALED RTISSDAVLQRLPEEARHRRVFEMVEALQEHPRDPNQILIGYSRGLVVIWDLQGSRVLYHFLSSQQLENIWWQRDGRLLVSCHSDGSYCQ WPVSSEAQQPEPLRSLVPYGPFPCKAITRILWLTTRQGLPFTIFQGGMPRASYGDRHCISVIHDGQQTAFDFTSRVIGFTVLTEADPAAN LHLAAELGKTLLERNKELEGSLQQMYSTNEEQVQEIEYLTKQLDTLRHVNEQHAKVYEQLDLTARDLELTNHRLVLESKAAQQKIHGLTE TIERLQAQVEELQAQVEQLRGLEQLRVLREKRERRRTIHTFPCLKELCTSPRCKDAFRLHSSSLELGPRPLEQENERLQTLVGALRSQVS QERQRKERAEREYTAVLQEYSELERQLCEMEACRLRVQELEAELLELQQMKQAKTYLLGPDDHLAEALLAPLTQAPEADDPQPGRGDDLG AQDGVSSPAASPGHVVRKSCSDTALNAIVAKDPASRHAGNLTLHANSVRKRGMSILREVDEQYHALLEKYEELLSKCRQHGAGVRHAGVQ -------------------------------------------------------------- >45691_45691_4_LLGL2-CDR2L_LLGL2_chr17_73560588_ENST00000578363_CDR2L_chr17_72995599_ENST00000337231_length(transcript)=4283nt_BP=1238nt GCCGAGGGACGCCGAGGCCTCGGGCGGGGGCTGGCCCGGGGTTCCAGATGTTGGATGTGATCCTTAAACAAAGCAAAGATGTCTGCCGTC GTTGAAAGTTGTTTCTAAAAGGTCTCCAGTGGGGGCTGCAGACTAAGCAAAATGAGGCGGTTCCTGAGGCCAGGGCATGACCCTGTGCGG GAGAGGCTCAAGCGGGACCTGTTCCAGTTTAACAAGACGGTGGAGCATGGCTTCCCGCACCAGCCCAGCGCCCTCGGCTACAGCCCGTCC CTGCGCATCCTGGCCATCGGCACCCGTTCTGGAGCCATCAAGCTCTACGGAGCCCCAGGCGTGGAGTTCATGGGGCTGCACCAGGAGAAC AACGCTGTGACGCAGATCCACCTCCTGCCCGGCCAGTGCCAGCTGGTCACCCTGCTGGATGACAACAGCCTGCACCTTTGGAGCCTGAAG GTCAAGGGCGGGGCATCGGAGCTGCAGGAGGATGAGAGCTTCACACTGCGTGGACCCCCAGGGGCTGCCCCCAGTGCCACACAGATCACC GTGGTCCTGCCACATTCCTCCTGCGAGCTGCTCTACCTGGGCACCGAGAGTGGCAACGTGTTTGTGGTGCAGCTGCCAGCTTTTCGTGCG CTGGAGGACCGGACCATCAGCTCGGACGCGGTGCTGCAGCGGTTGCCAGAGGAGGCCCGCCACCGGCGTGTGTTCGAGATGGTGGAGGCA CTGCAGGAGCACCCTCGAGACCCCAACCAGATCCTGATCGGCTACAGCCGAGGCCTCGTTGTCATCTGGGACCTACAGGGCAGCCGCGTG CTCTACCACTTCCTCAGCAGCCAGCAACTGGAGAACATCTGGTGGCAGCGGGACGGCCGCCTGCTCGTCAGCTGTCACTCTGACGGCAGC TACTGCCAGTGGCCCGTGTCCAGCGAAGCCCAGCAACCAGAGCCCCTCCGCAGCCTCGTGCCTTACGGTCCCTTTCCTTGCAAAGCGATT ACCAGAATCCTCTGGCTGACCACTAGGCAGGGGTAGGAGAGCTTCGGGAGTGGGTGCCCAGGGTTAGGTGTGGGAGGCATGGGGCAGGAC CATCAGTAAAGACAGGGCCAGGTGCAGTGGCTCCTGCCTGTAACCCCAGTGCTGTGGGAGGCCAAGGTGGTAGGATCGCTTGAACCCAGG AGTTCAAGTCCAGCCTGGACAACGTAGGGAGACCCTTGTCTCTACAAAAAATAAAAAAATTAGCCAGGACTTGCACCTAGCTGCGGAGCT GGGGAAGACTCTGCTGGAGAGGAACAAGGAGCTGGAGGGGTCCCTGCAGCAGATGTACTCCACCAATGAGGAACAGGTGCAGGAGATCGA GTACCTAACCAAGCAGCTGGACACGCTGCGGCACGTGAACGAGCAGCACGCCAAAGTCTATGAGCAGCTGGACCTGACAGCCCGGGACCT GGAGCTGACCAACCACAGGCTGGTGCTGGAGAGTAAGGCTGCCCAGCAGAAGATCCATGGGCTGACGGAGACCATTGAGCGCCTCCAGGC TCAGGTGGAGGAGCTGCAGGCCCAGGTGGAGCAACTGAGAGGCCTGGAACAGCTGCGAGTGCTCCGGGAGAAGCGGGAACGCAGGCGTAC CATCCACACCTTCCCCTGCCTCAAGGAGCTGTGCACCAGCCCCCGGTGCAAGGATGCTTTCCGCCTACACAGTTCCTCCCTGGAGCTGGG CCCGCGGCCCCTGGAGCAGGAGAACGAGCGGCTGCAGACCCTGGTGGGGGCGCTGCGCTCCCAGGTGAGCCAGGAGCGGCAGCGCAAGGA GCGGGCGGAGCGCGAGTACACCGCGGTGCTGCAGGAGTACTCGGAGCTGGAGCGCCAGCTGTGCGAGATGGAGGCCTGTCGCCTGCGTGT GCAGGAGCTGGAGGCCGAGCTGCTGGAGCTGCAGCAGATGAAGCAGGCCAAGACCTACCTACTGGGTCCGGACGACCACCTGGCCGAGGC CCTGCTCGCACCCCTCACGCAGGCCCCTGAGGCCGACGATCCCCAGCCCGGCCGCGGGGACGACTTGGGCGCCCAGGACGGGGTCTCCTC ACCGGCAGCCTCTCCAGGCCACGTGGTGCGCAAGAGCTGCAGCGACACTGCGCTCAACGCCATCGTGGCCAAAGACCCAGCCAGCCGGCA CGCGGGCAACCTCACACTGCACGCCAACAGCGTGCGCAAGCGGGGCATGTCCATCCTGCGGGAGGTGGACGAGCAGTACCACGCGCTGCT GGAGAAGTACGAGGAGCTGCTGAGCAAGTGCCGGCAGCACGGGGCCGGAGTGCGGCACGCCGGCGTGCAGACCTCGCGCCCCATCTCCCG GGACAGCTCGTGGAGGGACCTGCGCGGGGGTGAGGAGGGCCAGGGTGAGGTCAAGGCAGGAGAGAAGAGCCTGAGCCAGCACGTGGAGGC CGTGGACAAGCGGCTGGAACAGAGCCAGCCCGAGTACAAGGCGCTCTTCAAAGAGATCTTCTCCAGGATCCAGAAGACCAAGGCTGACAT CAACGCCACCAAAGTCAAGACGCACAGCAGCAAGTGACCCTTCTCCGGCCTGCAGCCTCCCCCAGGGTGGAAGCCGTGGGGTCCCTCAGG CCTGGGCGGTGCAGCTTCCAGAGAGCGAGCGCCCTTTAGCGGCCTGCCACCACAGCACGCGGCCTCCTGATCCGGAAGCACGCAGCATGT TCCCTGCTGAGCGGAGGCAGCCCACCTGTCCTGCCTCCCAGGAGCCCTTGGCCACCTCGCGCCAGCCCAAAGGCGCAGCTCTGAGTTCAA AGCCAAATGTCCCCACTACCCCAGGGATCCCCCAGCTCCCCCAGCCCCTGGCTTCCTGACCCTGCGCCTCACCCTCAGACTGGTGACCAG GCTTCTGAAAGCCATTCTGGATCAGTTGGCTTTTTTTTTTTTTTTGGTTAAGTTTGTTTTTTCTAAGAGATTTGCAATGCAAGGTCTCCT TGACCCCTTGCCACAACTGGAAACACTTGAAAGGGGACCCCAGGGCCAGCTGTTTCAGGGGTTTCCTGGACCACCCACTGCTTCTCCCCA ACCCTGATGCGCTGACATTCCCTTAGCACCAGCTGTCCCACCTCCAGGGTCCTGACCAGGTCAGAGATGTCCCCTGCCATGCAGAGCAGG AAGCCTCAGCTGGGCCTGGAGTGTCCCTGCTCCAGCCCTGCCAGGGACAGGTTTCTCCCTGGATACTCTTGGCCCACCGCAGATCTGTAG CCAGTCAGAGGAGGAGGAGAAGGAGCCCCTCAGCAGAGTGGTGCAGTTTCGCTCAGAGCTTGTCTCCTTGGCTTCCAACCCCAGAAATGC CTGCTGGGCCTTAAGCTTTCCAGGGGCCGGGGCAGTGGGGAGCCCCCATCCCTTCACACCGCCACCAACTAACCAAGCTTGGCCTCTGAC TCCCGTCTCTGTGCTTGCCCCCATCTCAGGGACCATGATGTCTCAGTCACTCCACGCTCCCCACAGGCCAACCCTGGCACAGGTCATGTC TGCAGCCCCCAGAATGTTCTGGACATGCACCACCAGCCGGTGGTCCCAATGTCCACCCCTGCCTCCCCTTCACTGGGGACTGGGGTTTTC GCCCCATGCTGCATCGTGTTGTATTGGGATGGGGCTGAGGAACATGCTCCCTCCCTCCCTCCCATAAAATGCCTGCTCTTCACCTCCCAC CTTTGTGGGGGGCTTTTGAGGACCCAGCTGCGTCAGGAGTTTTGCTTCAAGATGTCAGAAAGTCAAGTTCAGCTAAGAGACACCCAGGTC CCCAGCTTGCCCTGAGCAGCCCTTCAGGGCTTCTGGTTCCTTCTGCCGCCCTTCCTGAGACCTTAGAAACCAGAAGAGCCATACAGTCAG TGGAAGGCGGGGGGGCCCTGGCCTCTGCACCGGGATCCCAGTGGGAACCTTCATGCCTTATTTATTTCTAATGGGTAAAGGGGTTTTCTT ACCAAGCATCCCTGACCTCCTGGAGACACCACCTGCTTTCCGGGCGGCACTGTGATGGGAGCTGGTGGCGACTGAGTCCTTCTGTACGTG CAACTGGGAAACTTTTGTCCTTTGAGGCTAGGCAGCTCCCTGCCCTCCGTGTGTGTCTGTTATCTGGGGGAGAGGAGTGTGGAAGGGTTG GGGGAAGAGCTCCAGCCTGTCTGCTCCCCAGCTCTGTAGTGGCAGACCAGCGTCACCTTTGAAGTATACGTGAGAGAAATATATTTACAA >45691_45691_4_LLGL2-CDR2L_LLGL2_chr17_73560588_ENST00000578363_CDR2L_chr17_72995599_ENST00000337231_length(amino acids)=465AA_BP=16 MNPGVQVQPGQRRETLVSTKNKKISQDLHLAAELGKTLLERNKELEGSLQQMYSTNEEQVQEIEYLTKQLDTLRHVNEQHAKVYEQLDLT ARDLELTNHRLVLESKAAQQKIHGLTETIERLQAQVEELQAQVEQLRGLEQLRVLREKRERRRTIHTFPCLKELCTSPRCKDAFRLHSSS LELGPRPLEQENERLQTLVGALRSQVSQERQRKERAEREYTAVLQEYSELERQLCEMEACRLRVQELEAELLELQQMKQAKTYLLGPDDH LAEALLAPLTQAPEADDPQPGRGDDLGAQDGVSSPAASPGHVVRKSCSDTALNAIVAKDPASRHAGNLTLHANSVRKRGMSILREVDEQY HALLEKYEELLSKCRQHGAGVRHAGVQTSRPISRDSSWRDLRGGEEGQGEVKAGEKSLSQHVEAVDKRLEQSQPEYKALFKEIFSRIQKT -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for LLGL2-CDR2L |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for LLGL2-CDR2L |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for LLGL2-CDR2L |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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