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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ABI2-CYP20A1 (FusionGDB2 ID:457)

Fusion Gene Summary for ABI2-CYP20A1

check button Fusion gene summary
Fusion gene informationFusion gene name: ABI2-CYP20A1
Fusion gene ID: 457
HgeneTgene
Gene symbol

ABI2

CYP20A1

Gene ID

10152

57404

Gene nameabl interactor 2cytochrome P450 family 20 subfamily A member 1
SynonymsABI-2|ABI2B|AIP-1|AIP1|AblBP3|SSH3BP2|argBP1|argBPIA|argBPIBCYP-M
Cytomap

2q33.2

2q33.2

Type of geneprotein-codingprotein-coding
Descriptionabl interactor 2abelson interactor 2abl binding protein 3abl-interacting protein 1 (SH3-containing protein)abl-interactor protein 2barg protein tyrosine kinase-binding proteinarg-binding protein 1cytochrome P450 20A1cytochrome P450 monooxygenasecytochrome P450, family 20, subfamily A, polypeptide 1
Modification date2020032720200313
UniProtAcc

Q9NYB9

Q6UW02

Ensembl transtripts involved in fusion geneENST00000261016, ENST00000261017, 
ENST00000295851, ENST00000422511, 
ENST00000424558, ENST00000430418, 
ENST00000261018, ENST00000430574, 
ENST00000429815, ENST00000461371, 
ENST00000356079, 
Fusion gene scores* DoF score14 X 7 X 8=7848 X 11 X 5=440
# samples 179
** MAII scorelog2(17/784*10)=-2.20531890797751
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/440*10)=-2.28950661719499
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ABI2 [Title/Abstract] AND CYP20A1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointABI2(204193354)-CYP20A1(204154488), # samples:2
CYP20A1(204144836)-ABI2(204267299), # samples:1
Anticipated loss of major functional domain due to fusion event.ABI2-CYP20A1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
ABI2-CYP20A1 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
ABI2-CYP20A1 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneABI2

GO:0016601

Rac protein signal transduction

21107423

HgeneABI2

GO:0018108

peptidyl-tyrosine phosphorylation

17101133

HgeneABI2

GO:2000601

positive regulation of Arp2/3 complex-mediated actin nucleation

21107423


check buttonFusion gene breakpoints across ABI2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CYP20A1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A7-A26G-01AABI2chr2

204193354

+CYP20A1chr2

204154488

+
ChimerDB4BRCATCGA-A7-A26G-01AABI2chr2

204231767

+CYP20A1chr2

204161197

+
ChimerDB4BRCATCGA-A7-A26G-01AABI2chr2

204231767

+CYP20A1chr2

204161481

+
ChimerDB4OVTCGA-13-0908-01BABI2chr2

204193354

+CYP20A1chr2

204156985

+


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Fusion Gene ORF analysis for ABI2-CYP20A1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000261016ENST00000429815ABI2chr2

204231767

+CYP20A1chr2

204161197

+
5CDS-3UTRENST00000261016ENST00000429815ABI2chr2

204231767

+CYP20A1chr2

204161481

+
5CDS-3UTRENST00000261016ENST00000461371ABI2chr2

204231767

+CYP20A1chr2

204161197

+
5CDS-3UTRENST00000261016ENST00000461371ABI2chr2

204231767

+CYP20A1chr2

204161481

+
5CDS-3UTRENST00000261017ENST00000429815ABI2chr2

204193354

+CYP20A1chr2

204154488

+
5CDS-3UTRENST00000261017ENST00000429815ABI2chr2

204231767

+CYP20A1chr2

204161197

+
5CDS-3UTRENST00000261017ENST00000429815ABI2chr2

204231767

+CYP20A1chr2

204161481

+
5CDS-3UTRENST00000261017ENST00000429815ABI2chr2

204193354

+CYP20A1chr2

204156985

+
5CDS-3UTRENST00000261017ENST00000461371ABI2chr2

204193354

+CYP20A1chr2

204154488

+
5CDS-3UTRENST00000261017ENST00000461371ABI2chr2

204231767

+CYP20A1chr2

204161197

+
5CDS-3UTRENST00000261017ENST00000461371ABI2chr2

204231767

+CYP20A1chr2

204161481

+
5CDS-3UTRENST00000261017ENST00000461371ABI2chr2

204193354

+CYP20A1chr2

204156985

+
5CDS-3UTRENST00000295851ENST00000429815ABI2chr2

204193354

+CYP20A1chr2

204154488

+
5CDS-3UTRENST00000295851ENST00000429815ABI2chr2

204231767

+CYP20A1chr2

204161197

+
5CDS-3UTRENST00000295851ENST00000429815ABI2chr2

204231767

+CYP20A1chr2

204161481

+
5CDS-3UTRENST00000295851ENST00000429815ABI2chr2

204193354

+CYP20A1chr2

204156985

+
5CDS-3UTRENST00000295851ENST00000461371ABI2chr2

204193354

+CYP20A1chr2

204154488

+
5CDS-3UTRENST00000295851ENST00000461371ABI2chr2

204231767

+CYP20A1chr2

204161197

+
5CDS-3UTRENST00000295851ENST00000461371ABI2chr2

204231767

+CYP20A1chr2

204161481

+
5CDS-3UTRENST00000295851ENST00000461371ABI2chr2

204193354

+CYP20A1chr2

204156985

+
5CDS-3UTRENST00000422511ENST00000429815ABI2chr2

204193354

+CYP20A1chr2

204154488

+
5CDS-3UTRENST00000422511ENST00000429815ABI2chr2

204231767

+CYP20A1chr2

204161197

+
5CDS-3UTRENST00000422511ENST00000429815ABI2chr2

204231767

+CYP20A1chr2

204161481

+
5CDS-3UTRENST00000422511ENST00000429815ABI2chr2

204193354

+CYP20A1chr2

204156985

+
5CDS-3UTRENST00000422511ENST00000461371ABI2chr2

204193354

+CYP20A1chr2

204154488

+
5CDS-3UTRENST00000422511ENST00000461371ABI2chr2

204231767

+CYP20A1chr2

204161197

+
5CDS-3UTRENST00000422511ENST00000461371ABI2chr2

204231767

+CYP20A1chr2

204161481

+
5CDS-3UTRENST00000422511ENST00000461371ABI2chr2

204193354

+CYP20A1chr2

204156985

+
5CDS-3UTRENST00000424558ENST00000429815ABI2chr2

204193354

+CYP20A1chr2

204154488

+
5CDS-3UTRENST00000424558ENST00000429815ABI2chr2

204231767

+CYP20A1chr2

204161197

+
5CDS-3UTRENST00000424558ENST00000429815ABI2chr2

204231767

+CYP20A1chr2

204161481

+
5CDS-3UTRENST00000424558ENST00000429815ABI2chr2

204193354

+CYP20A1chr2

204156985

+
5CDS-3UTRENST00000424558ENST00000461371ABI2chr2

204193354

+CYP20A1chr2

204154488

+
5CDS-3UTRENST00000424558ENST00000461371ABI2chr2

204231767

+CYP20A1chr2

204161197

+
5CDS-3UTRENST00000424558ENST00000461371ABI2chr2

204231767

+CYP20A1chr2

204161481

+
5CDS-3UTRENST00000424558ENST00000461371ABI2chr2

204193354

+CYP20A1chr2

204156985

+
5CDS-3UTRENST00000430418ENST00000429815ABI2chr2

204193354

+CYP20A1chr2

204154488

+
5CDS-3UTRENST00000430418ENST00000429815ABI2chr2

204231767

+CYP20A1chr2

204161197

+
5CDS-3UTRENST00000430418ENST00000429815ABI2chr2

204231767

+CYP20A1chr2

204161481

+
5CDS-3UTRENST00000430418ENST00000429815ABI2chr2

204193354

+CYP20A1chr2

204156985

+
5CDS-3UTRENST00000430418ENST00000461371ABI2chr2

204193354

+CYP20A1chr2

204154488

+
5CDS-3UTRENST00000430418ENST00000461371ABI2chr2

204231767

+CYP20A1chr2

204161197

+
5CDS-3UTRENST00000430418ENST00000461371ABI2chr2

204231767

+CYP20A1chr2

204161481

+
5CDS-3UTRENST00000430418ENST00000461371ABI2chr2

204193354

+CYP20A1chr2

204156985

+
5UTR-3CDSENST00000261016ENST00000356079ABI2chr2

204193354

+CYP20A1chr2

204154488

+
5UTR-3CDSENST00000261016ENST00000356079ABI2chr2

204193354

+CYP20A1chr2

204156985

+
5UTR-3UTRENST00000261016ENST00000429815ABI2chr2

204193354

+CYP20A1chr2

204154488

+
5UTR-3UTRENST00000261016ENST00000429815ABI2chr2

204193354

+CYP20A1chr2

204156985

+
5UTR-3UTRENST00000261016ENST00000461371ABI2chr2

204193354

+CYP20A1chr2

204154488

+
5UTR-3UTRENST00000261016ENST00000461371ABI2chr2

204193354

+CYP20A1chr2

204156985

+
Frame-shiftENST00000261016ENST00000356079ABI2chr2

204231767

+CYP20A1chr2

204161481

+
Frame-shiftENST00000261017ENST00000356079ABI2chr2

204193354

+CYP20A1chr2

204154488

+
Frame-shiftENST00000261017ENST00000356079ABI2chr2

204231767

+CYP20A1chr2

204161197

+
Frame-shiftENST00000261017ENST00000356079ABI2chr2

204231767

+CYP20A1chr2

204161481

+
Frame-shiftENST00000295851ENST00000356079ABI2chr2

204193354

+CYP20A1chr2

204154488

+
Frame-shiftENST00000295851ENST00000356079ABI2chr2

204231767

+CYP20A1chr2

204161197

+
Frame-shiftENST00000295851ENST00000356079ABI2chr2

204231767

+CYP20A1chr2

204161481

+
Frame-shiftENST00000422511ENST00000356079ABI2chr2

204193354

+CYP20A1chr2

204154488

+
Frame-shiftENST00000422511ENST00000356079ABI2chr2

204231767

+CYP20A1chr2

204161197

+
Frame-shiftENST00000422511ENST00000356079ABI2chr2

204231767

+CYP20A1chr2

204161481

+
Frame-shiftENST00000424558ENST00000356079ABI2chr2

204193354

+CYP20A1chr2

204154488

+
Frame-shiftENST00000424558ENST00000356079ABI2chr2

204231767

+CYP20A1chr2

204161197

+
Frame-shiftENST00000424558ENST00000356079ABI2chr2

204231767

+CYP20A1chr2

204161481

+
Frame-shiftENST00000430418ENST00000356079ABI2chr2

204193354

+CYP20A1chr2

204154488

+
Frame-shiftENST00000430418ENST00000356079ABI2chr2

204231767

+CYP20A1chr2

204161197

+
Frame-shiftENST00000430418ENST00000356079ABI2chr2

204231767

+CYP20A1chr2

204161481

+
In-frameENST00000261016ENST00000356079ABI2chr2

204231767

+CYP20A1chr2

204161197

+
In-frameENST00000261017ENST00000356079ABI2chr2

204193354

+CYP20A1chr2

204156985

+
In-frameENST00000295851ENST00000356079ABI2chr2

204193354

+CYP20A1chr2

204156985

+
In-frameENST00000422511ENST00000356079ABI2chr2

204193354

+CYP20A1chr2

204156985

+
In-frameENST00000424558ENST00000356079ABI2chr2

204193354

+CYP20A1chr2

204156985

+
In-frameENST00000430418ENST00000356079ABI2chr2

204193354

+CYP20A1chr2

204156985

+
intron-3CDSENST00000261018ENST00000356079ABI2chr2

204193354

+CYP20A1chr2

204154488

+
intron-3CDSENST00000261018ENST00000356079ABI2chr2

204231767

+CYP20A1chr2

204161197

+
intron-3CDSENST00000261018ENST00000356079ABI2chr2

204231767

+CYP20A1chr2

204161481

+
intron-3CDSENST00000261018ENST00000356079ABI2chr2

204193354

+CYP20A1chr2

204156985

+
intron-3CDSENST00000430574ENST00000356079ABI2chr2

204193354

+CYP20A1chr2

204154488

+
intron-3CDSENST00000430574ENST00000356079ABI2chr2

204231767

+CYP20A1chr2

204161197

+
intron-3CDSENST00000430574ENST00000356079ABI2chr2

204231767

+CYP20A1chr2

204161481

+
intron-3CDSENST00000430574ENST00000356079ABI2chr2

204193354

+CYP20A1chr2

204156985

+
intron-3UTRENST00000261018ENST00000429815ABI2chr2

204193354

+CYP20A1chr2

204154488

+
intron-3UTRENST00000261018ENST00000429815ABI2chr2

204231767

+CYP20A1chr2

204161197

+
intron-3UTRENST00000261018ENST00000429815ABI2chr2

204231767

+CYP20A1chr2

204161481

+
intron-3UTRENST00000261018ENST00000429815ABI2chr2

204193354

+CYP20A1chr2

204156985

+
intron-3UTRENST00000261018ENST00000461371ABI2chr2

204193354

+CYP20A1chr2

204154488

+
intron-3UTRENST00000261018ENST00000461371ABI2chr2

204231767

+CYP20A1chr2

204161197

+
intron-3UTRENST00000261018ENST00000461371ABI2chr2

204231767

+CYP20A1chr2

204161481

+
intron-3UTRENST00000261018ENST00000461371ABI2chr2

204193354

+CYP20A1chr2

204156985

+
intron-3UTRENST00000430574ENST00000429815ABI2chr2

204193354

+CYP20A1chr2

204154488

+
intron-3UTRENST00000430574ENST00000429815ABI2chr2

204231767

+CYP20A1chr2

204161197

+
intron-3UTRENST00000430574ENST00000429815ABI2chr2

204231767

+CYP20A1chr2

204161481

+
intron-3UTRENST00000430574ENST00000429815ABI2chr2

204193354

+CYP20A1chr2

204156985

+
intron-3UTRENST00000430574ENST00000461371ABI2chr2

204193354

+CYP20A1chr2

204154488

+
intron-3UTRENST00000430574ENST00000461371ABI2chr2

204231767

+CYP20A1chr2

204161197

+
intron-3UTRENST00000430574ENST00000461371ABI2chr2

204231767

+CYP20A1chr2

204161481

+
intron-3UTRENST00000430574ENST00000461371ABI2chr2

204193354

+CYP20A1chr2

204156985

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for ABI2-CYP20A1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ABI2chr2204193354+CYP20A1chr2204154487+1.60E-121
ABI2chr2204231767+CYP20A1chr2204161196+4.02E-101
ABI2chr2204231767+CYP20A1chr2204161480+3.26E-101
ABI2chr2204193354+CYP20A1chr2204156984+8.28E-141
ABI2chr2204193354+CYP20A1chr2204154487+1.60E-121
ABI2chr2204231767+CYP20A1chr2204161196+4.02E-101
ABI2chr2204231767+CYP20A1chr2204161480+3.26E-101
ABI2chr2204193354+CYP20A1chr2204156984+8.28E-141

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for ABI2-CYP20A1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:204193354/chr2:204154488)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ABI2

Q9NYB9

CYP20A1

Q6UW02

FUNCTION: Regulator of actin cytoskeleton dynamics underlying cell motility and adhesion. Functions as a component of the WAVE complex, which activates actin nucleating machinery Arp2/3 to drive lamellipodia formation (PubMed:21107423). Acts as regulator and substrate of nonreceptor tyrosine kinases ABL1 and ABL2 involved in processes linked to cell growth and differentiation. Positively regulates ABL1-mediated phosphorylation of ENAH, which is required for proper polymerization of nucleated actin filaments at the leading edge (PubMed:7590236, PubMed:8649853, PubMed:10498863). Contributes to the regulation of actin assembly at the tips of neuron projections. In particular, controls dendritic spine morphogenesis and may promote dendritic spine specification toward large mushroom-type spines known as repositories of memory in the brain (By similarity). In hippocampal neurons, may mediate actin-dependent BDNF-NTRK2 early endocytic trafficking that triggers dendrite outgrowth (By similarity). Participates in ocular lens morphogenesis, likely by regulating lamellipodia-driven adherens junction formation at the epithelial cell-secondary lens fiber interface (By similarity). Also required for nascent adherens junction assembly in epithelial cells (PubMed:15572692). {ECO:0000250|UniProtKB:P62484, ECO:0000269|PubMed:10498863, ECO:0000269|PubMed:15572692, ECO:0000269|PubMed:21107423, ECO:0000269|PubMed:7590236, ECO:0000269|PubMed:8649853}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneABI2chr2:204193354chr2:204156985ENST00000261016+110172_4230402.0Compositional biasNote=Pro-rich
HgeneABI2chr2:204193354chr2:204156985ENST00000261017+110172_42339476.0Compositional biasNote=Pro-rich
HgeneABI2chr2:204193354chr2:204156985ENST00000424558+110172_42339508.0Compositional biasNote=Pro-rich
HgeneABI2chr2:204231767chr2:204161197ENST00000261016+210172_42324402.0Compositional biasNote=Pro-rich
HgeneABI2chr2:204231767chr2:204161197ENST00000261017+210172_42395476.0Compositional biasNote=Pro-rich
HgeneABI2chr2:204231767chr2:204161197ENST00000424558+210172_42395508.0Compositional biasNote=Pro-rich
HgeneABI2chr2:204193354chr2:204156985ENST00000261016+110451_5100402.0DomainSH3
HgeneABI2chr2:204193354chr2:204156985ENST00000261016+11045_1070402.0Domaint-SNARE coiled-coil homology
HgeneABI2chr2:204193354chr2:204156985ENST00000261017+110451_51039476.0DomainSH3
HgeneABI2chr2:204193354chr2:204156985ENST00000261017+11045_10739476.0Domaint-SNARE coiled-coil homology
HgeneABI2chr2:204193354chr2:204156985ENST00000424558+110451_51039508.0DomainSH3
HgeneABI2chr2:204193354chr2:204156985ENST00000424558+11045_10739508.0Domaint-SNARE coiled-coil homology
HgeneABI2chr2:204231767chr2:204161197ENST00000261016+210451_51024402.0DomainSH3
HgeneABI2chr2:204231767chr2:204161197ENST00000261016+21045_10724402.0Domaint-SNARE coiled-coil homology
HgeneABI2chr2:204231767chr2:204161197ENST00000261017+210451_51095476.0DomainSH3
HgeneABI2chr2:204231767chr2:204161197ENST00000261017+21045_10795476.0Domaint-SNARE coiled-coil homology
HgeneABI2chr2:204231767chr2:204161197ENST00000424558+210451_51095508.0DomainSH3
HgeneABI2chr2:204231767chr2:204161197ENST00000424558+21045_10795508.0Domaint-SNARE coiled-coil homology
TgeneCYP20A1chr2:204193354chr2:204156985ENST000003560799134_24361463.0TransmembraneHelical
TgeneCYP20A1chr2:204231767chr2:204161197ENST0000035607910134_24382463.0TransmembraneHelical


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Fusion Gene Sequence for ABI2-CYP20A1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for ABI2-CYP20A1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ABI2-CYP20A1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ABI2-CYP20A1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource