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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:LLGL2-TMEM104 (FusionGDB2 ID:45705)

Fusion Gene Summary for LLGL2-TMEM104

check button Fusion gene summary
Fusion gene informationFusion gene name: LLGL2-TMEM104
Fusion gene ID: 45705
HgeneTgene
Gene symbol

LLGL2

TMEM104

Gene ID

3993

54868

Gene nameLLGL scribble cell polarity complex component 2transmembrane protein 104
SynonymsHGL|Hugl-2|LGL2-
Cytomap

17q25.1

17q25.1

Type of geneprotein-codingprotein-coding
DescriptionLLGL scribble cell polarity complex component 2LLGL2, scribble cell polarity complex componenthuman giant larvae homologlethal giant larvae homolog 2, scribble cell polarity complex componentlethal(2) giant larvae protein homolog 2transmembrane protein 104
Modification date2020032020200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000167462, ENST00000392550, 
ENST00000577200, ENST00000375227, 
ENST00000578363, 		ENST00000417024, 
ENST00000582330, ENST00000582773, 
ENST00000584171, ENST00000335464, 
Fusion gene scores* DoF score17 X 14 X 10=23808 X 7 X 7=392
# samples 209
** MAII scorelog2(20/2380*10)=-3.57288966842058
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/392*10)=-2.12285674778553
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: LLGL2 [Title/Abstract] AND TMEM104 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointLLGL2(73568145)-TMEM104(72832066), # samples:2
Anticipated loss of major functional domain due to fusion event.LLGL2-TMEM104 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneLLGL2

GO:0032878

regulation of establishment or maintenance of cell polarity

12725730


check buttonFusion gene breakpoints across LLGL2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TMEM104 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-24-0970-01BLLGL2chr17

73567181

+TMEM104chr17

72832066

+
ChimerDB4OVTCGA-24-0970-01BLLGL2chr17

73568145

+TMEM104chr17

72832066

+
ChimerDB4OVTCGA-24-0970LLGL2chr17

73568145

+TMEM104chr17

72832065

+


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Fusion Gene ORF analysis for LLGL2-TMEM104

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000167462ENST00000417024LLGL2chr17

73567181

+TMEM104chr17

72832066

+
5CDS-intronENST00000167462ENST00000417024LLGL2chr17

73568145

+TMEM104chr17

72832066

+
5CDS-intronENST00000167462ENST00000417024LLGL2chr17

73568145

+TMEM104chr17

72832065

+
5CDS-intronENST00000167462ENST00000582330LLGL2chr17

73567181

+TMEM104chr17

72832066

+
5CDS-intronENST00000167462ENST00000582330LLGL2chr17

73568145

+TMEM104chr17

72832066

+
5CDS-intronENST00000167462ENST00000582330LLGL2chr17

73568145

+TMEM104chr17

72832065

+
5CDS-intronENST00000167462ENST00000582773LLGL2chr17

73567181

+TMEM104chr17

72832066

+
5CDS-intronENST00000167462ENST00000582773LLGL2chr17

73568145

+TMEM104chr17

72832066

+
5CDS-intronENST00000167462ENST00000582773LLGL2chr17

73568145

+TMEM104chr17

72832065

+
5CDS-intronENST00000167462ENST00000584171LLGL2chr17

73567181

+TMEM104chr17

72832066

+
5CDS-intronENST00000167462ENST00000584171LLGL2chr17

73568145

+TMEM104chr17

72832066

+
5CDS-intronENST00000167462ENST00000584171LLGL2chr17

73568145

+TMEM104chr17

72832065

+
5CDS-intronENST00000392550ENST00000417024LLGL2chr17

73567181

+TMEM104chr17

72832066

+
5CDS-intronENST00000392550ENST00000417024LLGL2chr17

73568145

+TMEM104chr17

72832066

+
5CDS-intronENST00000392550ENST00000417024LLGL2chr17

73568145

+TMEM104chr17

72832065

+
5CDS-intronENST00000392550ENST00000582330LLGL2chr17

73567181

+TMEM104chr17

72832066

+
5CDS-intronENST00000392550ENST00000582330LLGL2chr17

73568145

+TMEM104chr17

72832066

+
5CDS-intronENST00000392550ENST00000582330LLGL2chr17

73568145

+TMEM104chr17

72832065

+
5CDS-intronENST00000392550ENST00000582773LLGL2chr17

73567181

+TMEM104chr17

72832066

+
5CDS-intronENST00000392550ENST00000582773LLGL2chr17

73568145

+TMEM104chr17

72832066

+
5CDS-intronENST00000392550ENST00000582773LLGL2chr17

73568145

+TMEM104chr17

72832065

+
5CDS-intronENST00000392550ENST00000584171LLGL2chr17

73567181

+TMEM104chr17

72832066

+
5CDS-intronENST00000392550ENST00000584171LLGL2chr17

73568145

+TMEM104chr17

72832066

+
5CDS-intronENST00000392550ENST00000584171LLGL2chr17

73568145

+TMEM104chr17

72832065

+
5CDS-intronENST00000577200ENST00000417024LLGL2chr17

73567181

+TMEM104chr17

72832066

+
5CDS-intronENST00000577200ENST00000417024LLGL2chr17

73568145

+TMEM104chr17

72832066

+
5CDS-intronENST00000577200ENST00000417024LLGL2chr17

73568145

+TMEM104chr17

72832065

+
5CDS-intronENST00000577200ENST00000582330LLGL2chr17

73567181

+TMEM104chr17

72832066

+
5CDS-intronENST00000577200ENST00000582330LLGL2chr17

73568145

+TMEM104chr17

72832066

+
5CDS-intronENST00000577200ENST00000582330LLGL2chr17

73568145

+TMEM104chr17

72832065

+
5CDS-intronENST00000577200ENST00000582773LLGL2chr17

73567181

+TMEM104chr17

72832066

+
5CDS-intronENST00000577200ENST00000582773LLGL2chr17

73568145

+TMEM104chr17

72832066

+
5CDS-intronENST00000577200ENST00000582773LLGL2chr17

73568145

+TMEM104chr17

72832065

+
5CDS-intronENST00000577200ENST00000584171LLGL2chr17

73567181

+TMEM104chr17

72832066

+
5CDS-intronENST00000577200ENST00000584171LLGL2chr17

73568145

+TMEM104chr17

72832066

+
5CDS-intronENST00000577200ENST00000584171LLGL2chr17

73568145

+TMEM104chr17

72832065

+
Frame-shiftENST00000167462ENST00000335464LLGL2chr17

73568145

+TMEM104chr17

72832066

+
Frame-shiftENST00000167462ENST00000335464LLGL2chr17

73568145

+TMEM104chr17

72832065

+
Frame-shiftENST00000392550ENST00000335464LLGL2chr17

73568145

+TMEM104chr17

72832066

+
Frame-shiftENST00000392550ENST00000335464LLGL2chr17

73568145

+TMEM104chr17

72832065

+
Frame-shiftENST00000577200ENST00000335464LLGL2chr17

73568145

+TMEM104chr17

72832066

+
Frame-shiftENST00000577200ENST00000335464LLGL2chr17

73568145

+TMEM104chr17

72832065

+
In-frameENST00000167462ENST00000335464LLGL2chr17

73567181

+TMEM104chr17

72832066

+
In-frameENST00000392550ENST00000335464LLGL2chr17

73567181

+TMEM104chr17

72832066

+
In-frameENST00000577200ENST00000335464LLGL2chr17

73567181

+TMEM104chr17

72832066

+
intron-3CDSENST00000375227ENST00000335464LLGL2chr17

73567181

+TMEM104chr17

72832066

+
intron-3CDSENST00000375227ENST00000335464LLGL2chr17

73568145

+TMEM104chr17

72832066

+
intron-3CDSENST00000375227ENST00000335464LLGL2chr17

73568145

+TMEM104chr17

72832065

+
intron-3CDSENST00000578363ENST00000335464LLGL2chr17

73567181

+TMEM104chr17

72832066

+
intron-3CDSENST00000578363ENST00000335464LLGL2chr17

73568145

+TMEM104chr17

72832066

+
intron-3CDSENST00000578363ENST00000335464LLGL2chr17

73568145

+TMEM104chr17

72832065

+
intron-intronENST00000375227ENST00000417024LLGL2chr17

73567181

+TMEM104chr17

72832066

+
intron-intronENST00000375227ENST00000417024LLGL2chr17

73568145

+TMEM104chr17

72832066

+
intron-intronENST00000375227ENST00000417024LLGL2chr17

73568145

+TMEM104chr17

72832065

+
intron-intronENST00000375227ENST00000582330LLGL2chr17

73567181

+TMEM104chr17

72832066

+
intron-intronENST00000375227ENST00000582330LLGL2chr17

73568145

+TMEM104chr17

72832066

+
intron-intronENST00000375227ENST00000582330LLGL2chr17

73568145

+TMEM104chr17

72832065

+
intron-intronENST00000375227ENST00000582773LLGL2chr17

73567181

+TMEM104chr17

72832066

+
intron-intronENST00000375227ENST00000582773LLGL2chr17

73568145

+TMEM104chr17

72832066

+
intron-intronENST00000375227ENST00000582773LLGL2chr17

73568145

+TMEM104chr17

72832065

+
intron-intronENST00000375227ENST00000584171LLGL2chr17

73567181

+TMEM104chr17

72832066

+
intron-intronENST00000375227ENST00000584171LLGL2chr17

73568145

+TMEM104chr17

72832066

+
intron-intronENST00000375227ENST00000584171LLGL2chr17

73568145

+TMEM104chr17

72832065

+
intron-intronENST00000578363ENST00000417024LLGL2chr17

73567181

+TMEM104chr17

72832066

+
intron-intronENST00000578363ENST00000417024LLGL2chr17

73568145

+TMEM104chr17

72832066

+
intron-intronENST00000578363ENST00000417024LLGL2chr17

73568145

+TMEM104chr17

72832065

+
intron-intronENST00000578363ENST00000582330LLGL2chr17

73567181

+TMEM104chr17

72832066

+
intron-intronENST00000578363ENST00000582330LLGL2chr17

73568145

+TMEM104chr17

72832066

+
intron-intronENST00000578363ENST00000582330LLGL2chr17

73568145

+TMEM104chr17

72832065

+
intron-intronENST00000578363ENST00000582773LLGL2chr17

73567181

+TMEM104chr17

72832066

+
intron-intronENST00000578363ENST00000582773LLGL2chr17

73568145

+TMEM104chr17

72832066

+
intron-intronENST00000578363ENST00000582773LLGL2chr17

73568145

+TMEM104chr17

72832065

+
intron-intronENST00000578363ENST00000584171LLGL2chr17

73567181

+TMEM104chr17

72832066

+
intron-intronENST00000578363ENST00000584171LLGL2chr17

73568145

+TMEM104chr17

72832066

+
intron-intronENST00000578363ENST00000584171LLGL2chr17

73568145

+TMEM104chr17

72832065

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000167462LLGL2chr1773567181+ENST00000335464TMEM104chr1772832066+615923061303066978
ENST00000392550LLGL2chr1773567181+ENST00000335464TMEM104chr1772832066+614622931173053978
ENST00000577200LLGL2chr1773567181+ENST00000335464TMEM104chr1772832066+61332280623040992

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000167462ENST00000335464LLGL2chr1773567181+TMEM104chr1772832066+0.0035492490.9964508
ENST00000392550ENST00000335464LLGL2chr1773567181+TMEM104chr1772832066+0.0035004450.99649954
ENST00000577200ENST00000335464LLGL2chr1773567181+TMEM104chr1772832066+0.0036980920.9963019

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Fusion Genomic Features for LLGL2-TMEM104


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
LLGL2chr1773568145+TMEM104chr1772832065+6.85E-050.99993145
LLGL2chr1773568145+TMEM104chr1772832065+6.85E-050.99993145
LLGL2chr1773567181+TMEM104chr1772832065+1.73E-060.99999833
LLGL2chr1773568145+TMEM104chr1772832065+6.85E-050.99993145
LLGL2chr1773568145+TMEM104chr1772832065+6.85E-050.99993145
LLGL2chr1773567181+TMEM104chr1772832065+1.73E-060.99999833

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for LLGL2-TMEM104


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:73568145/chr17:72832066)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLLGL2chr17:73567181chr17:72832066ENST00000167462+1725132_1697251016.0RepeatNote=WD 3
HgeneLLGL2chr17:73567181chr17:72832066ENST00000167462+1725193_2277251016.0RepeatNote=WD 4
HgeneLLGL2chr17:73567181chr17:72832066ENST00000167462+1725233_2687251016.0RepeatNote=WD 5
HgeneLLGL2chr17:73567181chr17:72832066ENST00000167462+1725282_3247251016.0RepeatNote=WD 6
HgeneLLGL2chr17:73567181chr17:72832066ENST00000167462+1725332_3667251016.0RepeatNote=WD 7
HgeneLLGL2chr17:73567181chr17:72832066ENST00000167462+172536_697251016.0RepeatNote=WD 1
HgeneLLGL2chr17:73567181chr17:72832066ENST00000167462+1725388_4647251016.0RepeatNote=WD 8
HgeneLLGL2chr17:73567181chr17:72832066ENST00000167462+1725508_5837251016.0RepeatNote=WD 9
HgeneLLGL2chr17:73567181chr17:72832066ENST00000167462+1725592_6537251016.0RepeatNote=WD 10
HgeneLLGL2chr17:73567181chr17:72832066ENST00000167462+172576_1177251016.0RepeatNote=WD 2
HgeneLLGL2chr17:73567181chr17:72832066ENST00000392550+1726132_1697251021.0RepeatNote=WD 3
HgeneLLGL2chr17:73567181chr17:72832066ENST00000392550+1726193_2277251021.0RepeatNote=WD 4
HgeneLLGL2chr17:73567181chr17:72832066ENST00000392550+1726233_2687251021.0RepeatNote=WD 5
HgeneLLGL2chr17:73567181chr17:72832066ENST00000392550+1726282_3247251021.0RepeatNote=WD 6
HgeneLLGL2chr17:73567181chr17:72832066ENST00000392550+1726332_3667251021.0RepeatNote=WD 7
HgeneLLGL2chr17:73567181chr17:72832066ENST00000392550+172636_697251021.0RepeatNote=WD 1
HgeneLLGL2chr17:73567181chr17:72832066ENST00000392550+1726388_4647251021.0RepeatNote=WD 8
HgeneLLGL2chr17:73567181chr17:72832066ENST00000392550+1726508_5837251021.0RepeatNote=WD 9
HgeneLLGL2chr17:73567181chr17:72832066ENST00000392550+1726592_6537251021.0RepeatNote=WD 10
HgeneLLGL2chr17:73567181chr17:72832066ENST00000392550+172676_1177251021.0RepeatNote=WD 2
TgeneTMEM104chr17:73567181chr17:72832066ENST00000335464810255_276243497.0Topological domainExtracellular
TgeneTMEM104chr17:73567181chr17:72832066ENST00000335464810298_306243497.0Topological domainCytoplasmic
TgeneTMEM104chr17:73567181chr17:72832066ENST00000335464810328_354243497.0Topological domainExtracellular
TgeneTMEM104chr17:73567181chr17:72832066ENST00000335464810376_397243497.0Topological domainCytoplasmic
TgeneTMEM104chr17:73567181chr17:72832066ENST00000335464810419_421243497.0Topological domainExtracellular
TgeneTMEM104chr17:73567181chr17:72832066ENST00000335464810443_470243497.0Topological domainCytoplasmic
TgeneTMEM104chr17:73567181chr17:72832066ENST00000335464810492_496243497.0Topological domainExtracellular
TgeneTMEM104chr17:73567181chr17:72832066ENST00000582330810255_276243497.0Topological domainExtracellular
TgeneTMEM104chr17:73567181chr17:72832066ENST00000582330810298_306243497.0Topological domainCytoplasmic
TgeneTMEM104chr17:73567181chr17:72832066ENST00000582330810328_354243497.0Topological domainExtracellular
TgeneTMEM104chr17:73567181chr17:72832066ENST00000582330810376_397243497.0Topological domainCytoplasmic
TgeneTMEM104chr17:73567181chr17:72832066ENST00000582330810419_421243497.0Topological domainExtracellular
TgeneTMEM104chr17:73567181chr17:72832066ENST00000582330810443_470243497.0Topological domainCytoplasmic
TgeneTMEM104chr17:73567181chr17:72832066ENST00000582330810492_496243497.0Topological domainExtracellular
TgeneTMEM104chr17:73567181chr17:72832066ENST00000582773010168_2040315.0Topological domainExtracellular
TgeneTMEM104chr17:73567181chr17:72832066ENST000005827730101_100315.0Topological domainCytoplasmic
TgeneTMEM104chr17:73567181chr17:72832066ENST00000582773010226_2330315.0Topological domainCytoplasmic
TgeneTMEM104chr17:73567181chr17:72832066ENST00000582773010255_2760315.0Topological domainExtracellular
TgeneTMEM104chr17:73567181chr17:72832066ENST00000582773010298_3060315.0Topological domainCytoplasmic
TgeneTMEM104chr17:73567181chr17:72832066ENST00000582773010328_3540315.0Topological domainExtracellular
TgeneTMEM104chr17:73567181chr17:72832066ENST0000058277301032_360315.0Topological domainExtracellular
TgeneTMEM104chr17:73567181chr17:72832066ENST00000582773010376_3970315.0Topological domainCytoplasmic
TgeneTMEM104chr17:73567181chr17:72832066ENST00000582773010419_4210315.0Topological domainExtracellular
TgeneTMEM104chr17:73567181chr17:72832066ENST00000582773010443_4700315.0Topological domainCytoplasmic
TgeneTMEM104chr17:73567181chr17:72832066ENST00000582773010492_4960315.0Topological domainExtracellular
TgeneTMEM104chr17:73567181chr17:72832066ENST0000058277301058_1460315.0Topological domainCytoplasmic
TgeneTMEM104chr17:73567181chr17:72832066ENST00000335464810277_297243497.0TransmembraneHelical
TgeneTMEM104chr17:73567181chr17:72832066ENST00000335464810307_327243497.0TransmembraneHelical
TgeneTMEM104chr17:73567181chr17:72832066ENST00000335464810355_375243497.0TransmembraneHelical
TgeneTMEM104chr17:73567181chr17:72832066ENST00000335464810398_418243497.0TransmembraneHelical
TgeneTMEM104chr17:73567181chr17:72832066ENST00000335464810422_442243497.0TransmembraneHelical
TgeneTMEM104chr17:73567181chr17:72832066ENST00000335464810471_491243497.0TransmembraneHelical
TgeneTMEM104chr17:73567181chr17:72832066ENST00000582330810277_297243497.0TransmembraneHelical
TgeneTMEM104chr17:73567181chr17:72832066ENST00000582330810307_327243497.0TransmembraneHelical
TgeneTMEM104chr17:73567181chr17:72832066ENST00000582330810355_375243497.0TransmembraneHelical
TgeneTMEM104chr17:73567181chr17:72832066ENST00000582330810398_418243497.0TransmembraneHelical
TgeneTMEM104chr17:73567181chr17:72832066ENST00000582330810422_442243497.0TransmembraneHelical
TgeneTMEM104chr17:73567181chr17:72832066ENST00000582330810471_491243497.0TransmembraneHelical
TgeneTMEM104chr17:73567181chr17:72832066ENST0000058277301011_310315.0TransmembraneHelical
TgeneTMEM104chr17:73567181chr17:72832066ENST00000582773010147_1670315.0TransmembraneHelical
TgeneTMEM104chr17:73567181chr17:72832066ENST00000582773010205_2250315.0TransmembraneHelical
TgeneTMEM104chr17:73567181chr17:72832066ENST00000582773010234_2540315.0TransmembraneHelical
TgeneTMEM104chr17:73567181chr17:72832066ENST00000582773010277_2970315.0TransmembraneHelical
TgeneTMEM104chr17:73567181chr17:72832066ENST00000582773010307_3270315.0TransmembraneHelical
TgeneTMEM104chr17:73567181chr17:72832066ENST00000582773010355_3750315.0TransmembraneHelical
TgeneTMEM104chr17:73567181chr17:72832066ENST0000058277301037_570315.0TransmembraneHelical
TgeneTMEM104chr17:73567181chr17:72832066ENST00000582773010398_4180315.0TransmembraneHelical
TgeneTMEM104chr17:73567181chr17:72832066ENST00000582773010422_4420315.0TransmembraneHelical
TgeneTMEM104chr17:73567181chr17:72832066ENST00000582773010471_4910315.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLLGL2chr17:73567181chr17:72832066ENST00000167462+1725713_7697251016.0RepeatNote=WD 11
HgeneLLGL2chr17:73567181chr17:72832066ENST00000167462+1725778_8307251016.0RepeatNote=WD 12
HgeneLLGL2chr17:73567181chr17:72832066ENST00000167462+1725835_8887251016.0RepeatNote=WD 13
HgeneLLGL2chr17:73567181chr17:72832066ENST00000167462+1725902_9257251016.0RepeatNote=WD 14
HgeneLLGL2chr17:73567181chr17:72832066ENST00000375227+110132_1690357.0RepeatNote=WD 3
HgeneLLGL2chr17:73567181chr17:72832066ENST00000375227+110193_2270357.0RepeatNote=WD 4
HgeneLLGL2chr17:73567181chr17:72832066ENST00000375227+110233_2680357.0RepeatNote=WD 5
HgeneLLGL2chr17:73567181chr17:72832066ENST00000375227+110282_3240357.0RepeatNote=WD 6
HgeneLLGL2chr17:73567181chr17:72832066ENST00000375227+110332_3660357.0RepeatNote=WD 7
HgeneLLGL2chr17:73567181chr17:72832066ENST00000375227+11036_690357.0RepeatNote=WD 1
HgeneLLGL2chr17:73567181chr17:72832066ENST00000375227+110388_4640357.0RepeatNote=WD 8
HgeneLLGL2chr17:73567181chr17:72832066ENST00000375227+110508_5830357.0RepeatNote=WD 9
HgeneLLGL2chr17:73567181chr17:72832066ENST00000375227+110592_6530357.0RepeatNote=WD 10
HgeneLLGL2chr17:73567181chr17:72832066ENST00000375227+110713_7690357.0RepeatNote=WD 11
HgeneLLGL2chr17:73567181chr17:72832066ENST00000375227+11076_1170357.0RepeatNote=WD 2
HgeneLLGL2chr17:73567181chr17:72832066ENST00000375227+110778_8300357.0RepeatNote=WD 12
HgeneLLGL2chr17:73567181chr17:72832066ENST00000375227+110835_8880357.0RepeatNote=WD 13
HgeneLLGL2chr17:73567181chr17:72832066ENST00000375227+110902_9250357.0RepeatNote=WD 14
HgeneLLGL2chr17:73567181chr17:72832066ENST00000392550+1726713_7697251021.0RepeatNote=WD 11
HgeneLLGL2chr17:73567181chr17:72832066ENST00000392550+1726778_8307251021.0RepeatNote=WD 12
HgeneLLGL2chr17:73567181chr17:72832066ENST00000392550+1726835_8887251021.0RepeatNote=WD 13
HgeneLLGL2chr17:73567181chr17:72832066ENST00000392550+1726902_9257251021.0RepeatNote=WD 14
HgeneLLGL2chr17:73567181chr17:72832066ENST00000578363+111132_1690357.0RepeatNote=WD 3
HgeneLLGL2chr17:73567181chr17:72832066ENST00000578363+111193_2270357.0RepeatNote=WD 4
HgeneLLGL2chr17:73567181chr17:72832066ENST00000578363+111233_2680357.0RepeatNote=WD 5
HgeneLLGL2chr17:73567181chr17:72832066ENST00000578363+111282_3240357.0RepeatNote=WD 6
HgeneLLGL2chr17:73567181chr17:72832066ENST00000578363+111332_3660357.0RepeatNote=WD 7
HgeneLLGL2chr17:73567181chr17:72832066ENST00000578363+11136_690357.0RepeatNote=WD 1
HgeneLLGL2chr17:73567181chr17:72832066ENST00000578363+111388_4640357.0RepeatNote=WD 8
HgeneLLGL2chr17:73567181chr17:72832066ENST00000578363+111508_5830357.0RepeatNote=WD 9
HgeneLLGL2chr17:73567181chr17:72832066ENST00000578363+111592_6530357.0RepeatNote=WD 10
HgeneLLGL2chr17:73567181chr17:72832066ENST00000578363+111713_7690357.0RepeatNote=WD 11
HgeneLLGL2chr17:73567181chr17:72832066ENST00000578363+11176_1170357.0RepeatNote=WD 2
HgeneLLGL2chr17:73567181chr17:72832066ENST00000578363+111778_8300357.0RepeatNote=WD 12
HgeneLLGL2chr17:73567181chr17:72832066ENST00000578363+111835_8880357.0RepeatNote=WD 13
HgeneLLGL2chr17:73567181chr17:72832066ENST00000578363+111902_9250357.0RepeatNote=WD 14
TgeneTMEM104chr17:73567181chr17:72832066ENST00000335464810168_204243497.0Topological domainExtracellular
TgeneTMEM104chr17:73567181chr17:72832066ENST000003354648101_10243497.0Topological domainCytoplasmic
TgeneTMEM104chr17:73567181chr17:72832066ENST00000335464810226_233243497.0Topological domainCytoplasmic
TgeneTMEM104chr17:73567181chr17:72832066ENST0000033546481032_36243497.0Topological domainExtracellular
TgeneTMEM104chr17:73567181chr17:72832066ENST0000033546481058_146243497.0Topological domainCytoplasmic
TgeneTMEM104chr17:73567181chr17:72832066ENST00000582330810168_204243497.0Topological domainExtracellular
TgeneTMEM104chr17:73567181chr17:72832066ENST000005823308101_10243497.0Topological domainCytoplasmic
TgeneTMEM104chr17:73567181chr17:72832066ENST00000582330810226_233243497.0Topological domainCytoplasmic
TgeneTMEM104chr17:73567181chr17:72832066ENST0000058233081032_36243497.0Topological domainExtracellular
TgeneTMEM104chr17:73567181chr17:72832066ENST0000058233081058_146243497.0Topological domainCytoplasmic
TgeneTMEM104chr17:73567181chr17:72832066ENST0000033546481011_31243497.0TransmembraneHelical
TgeneTMEM104chr17:73567181chr17:72832066ENST00000335464810147_167243497.0TransmembraneHelical
TgeneTMEM104chr17:73567181chr17:72832066ENST00000335464810205_225243497.0TransmembraneHelical
TgeneTMEM104chr17:73567181chr17:72832066ENST00000335464810234_254243497.0TransmembraneHelical
TgeneTMEM104chr17:73567181chr17:72832066ENST0000033546481037_57243497.0TransmembraneHelical
TgeneTMEM104chr17:73567181chr17:72832066ENST0000058233081011_31243497.0TransmembraneHelical
TgeneTMEM104chr17:73567181chr17:72832066ENST00000582330810147_167243497.0TransmembraneHelical
TgeneTMEM104chr17:73567181chr17:72832066ENST00000582330810205_225243497.0TransmembraneHelical
TgeneTMEM104chr17:73567181chr17:72832066ENST00000582330810234_254243497.0TransmembraneHelical
TgeneTMEM104chr17:73567181chr17:72832066ENST0000058233081037_57243497.0TransmembraneHelical


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Fusion Gene Sequence for LLGL2-TMEM104


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>45705_45705_1_LLGL2-TMEM104_LLGL2_chr17_73567181_ENST00000167462_TMEM104_chr17_72832066_ENST00000335464_length(transcript)=6159nt_BP=2306nt
CGCCCAGCAGCCCGTGGGCAGGCGCGGCGGAGCGAGCGGGGCCGGCGGCGGGCGCCGAGGGACGCCGAGGCCTCGGGCGGGGGCTGGCCC
GGGGTTCCAGGTCTCCAGTGGGGGCTGCAGACTAAGCAAAATGAGGCGGTTCCTGAGGCCAGGGCATGACCCTGTGCGGGAGAGGCTCAA
GCGGGACCTGTTCCAGTTTAACAAGACGGTGGAGCATGGCTTCCCGCACCAGCCCAGCGCCCTCGGCTACAGCCCGTCCCTGCGCATCCT
GGCCATCGGCACCCGTTCTGGAGCCATCAAGCTCTACGGAGCCCCAGGCGTGGAGTTCATGGGGCTGCACCAGGAGAACAACGCTGTGAC
GCAGATCCACCTCCTGCCCGGCCAGTGCCAGCTGGTCACCCTGCTGGATGACAACAGCCTGCACCTTTGGAGCCTGAAGGTCAAGGGCGG
GGCATCGGAGCTGCAGGAGGATGAGAGCTTCACACTGCGTGGACCCCCAGGGGCTGCCCCCAGTGCCACACAGATCACCGTGGTCCTGCC
ACATTCCTCCTGCGAGCTGCTCTACCTGGGCACCGAGAGTGGCAACGTGTTTGTGGTGCAGCTGCCAGCTTTTCGTGCGCTGGAGGACCG
GACCATCAGCTCGGACGCGGTGCTGCAGCGGTTGCCAGAGGAGGCCCGCCACCGGCGTGTGTTCGAGATGGTGGAGGCACTGCAGGAGCA
CCCTCGAGACCCCAACCAGATCCTGATCGGCTACAGCCGAGGCCTCGTTGTCATCTGGGACCTACAGGGCAGCCGCGTGCTCTACCACTT
CCTCAGCAGCCAGCAACTGGAGAACATCTGGTGGCAGCGGGACGGCCGCCTGCTCGTCAGCTGTCACTCTGACGGCAGCTACTGCCAGTG
GCCCGTGTCCAGCGAAGCCCAGCAACCAGAGCCCCTCCGCAGCCTCGTGCCTTACGGTCCCTTTCCTTGCAAAGCGATTACCAGAATCCT
CTGGCTGACCACTAGGCAGGGGTTGCCCTTCACCATCTTCCAGGGTGGCATGCCACGGGCCAGCTACGGGGACCGCCACTGCATCTCAGT
GATCCACGATGGCCAGCAGACGGCCTTCGACTTCACCTCCCGTGTCATCGGCTTCACTGTCCTCACAGAGGCAGACCCTGCAGCCACCTT
TGACGACCCCTATGCCCTGGTGGTGCTGGCTGAGGAGGAGCTGGTGGTGATTGACCTGCAGACAGCAGGCTGGCCACCGGTCCAGCTGCC
CTACCTGGCTTCTCTGCACTGTTCCGCCATCACCTGCTCTCACCACGTCTCCAACATCCCGCTGAAGCTGTGGGAGCGGATCATTGCCGC
CGGCAGCCGGCAGAACGCACACTTCTCCACCATGGAGTGGCCAATTGATGGTGGCACCAGCCTGACCCCAGCCCCACCCCAGAGGGACCT
GCTGCTCACAGGGCACGAGGACGGCACGGTGCGGTTCTGGGATGCCTCGGGTGTCTGCCTGCGGCTGCTCTACAAACTCAGCACTGTGCG
CGTGTTCCTCACCGACACGGACCCCAACGAGAACTTCAGTGCCCAGGGCGAGGACGAGTGGCCCCCACTCCGCAAGGTGGGCTCCTTTGA
CCCCTACAGTGATGACCCCCGGCTGGGCATCCAGAAGATCTTCCTCTGCAAGTACAGCGGCTACCTGGCTGTGGCAGGCACGGCAGGGCA
GGTGCTGGTACTGGAACTGAATGACGAGGCAGCGGAGCAGGCTGTGGAGCAGGTGGAGGCCGACCTGCTGCAGGACCAAGAGGGCTACCG
CTGGAAGGGGCACGAGCGCCTGGCAGCCCGCTCAGGGCCCGTGCGCTTTGAGCCTGGCTTTCAGCCCTTCGTGTTGGTGCAGTGTCAGCC
CCCGGCTGTGGTCACCTCCTTGGCCCTGCACTCTGAGTGGCGGCTCGTGGCCTTCGGCACCAGCCATGGCTTTGGCCTCTTTGACCACCA
GCAGCGGCGGCAGGTCTTTGTTAAGTGCACACTGCACCCCAGTGACCAGCTGGCCTTGGAGGGCCCACTCTCCCGCGTCAAGTCCCTCAA
GAAGTCCTTGCGTCAGTCATTCCGCCGGATGCGTCGGAGCCGGGTGTCCAGCCGGAAGCGGCACCCGGCTGGCCCCCCAGGAGAGGCACA
GGAGGGGAGTGCCAAGGCTGAGCGGCCAGGCCTCCAGAACATGGAGCTGGCGCCTGTGCAGCGCAAGATCGAGGCTCGCTCGGCAGAGGA
CTCCTTCACAGGCTTCGTCCGGACCCTGTACTTTGCTGACACCTACCTGAAGGACACTTTCGCCGTCATGATTGTGCTGGCCCTGATCCG
CATCGGGCACGGACAAGGGGAGGGGCACCCGCCCCTGGCTGACTTCTCGGGGGTCCGGAACCTGTTTGGGGTGTGCGTCTACTCCTTCAT
GTGCCAGCACTCTCTGCCATCCCTCATTACCCCCGTCTCCTCCAAGCGCCACCTCACAAGGCTGGTGTTCCTGGACTACGTGCTGATCCT
GGCCTTCTACGGCCTCCTCTCCTTCACCGCCATCTTCTGCTTCCGCGGCGACAGCCTCATGGACATGTACACCCTCAACTTCGCGCGCTG
TGACGTCGTGGGCCTGGCCGCTGTGCGCTTTTTCCTGGGCCTCTTCCCCGTCTTCACCATCAGCACCAACTTCCCCATCATTGCCGTGAC
CCTGCGCAACAACTGGAAGACACTCTTCCACCGCGAGGGCGGCACGTACCCGTGGGTGGTGGACCGCGTCGTGTTTCCCACCATCACCCT
GGTGCCGCCTGTGCTGGTGGCCTTCTGCACCCACGACCTGGAGTCCCTGGTGGGCATCACAGGGGCCTACGCGGGCACCGGCATCCAGTA
CGTCATCCCCGCCTTCCTGGTGTACCACTGCCGCAGGGACACCCAGCTGGCCTTTGGCTGTGGGGTCAGCAACAAGCACAGGTCCCCTTT
CCGCCACACCTTCTGGGTGGGCTTCGTGCTGCTCTGGGCTTTCTCCTGCTTCATTTTCGTCACGGCCAATATCATCCTCAGCGAGACCAA
GCTCTGATGGCAGGACAGGCAGGTCTAGTGACAGGAGGCATAGGGGCCCCAGCCCCACCCCTCGCCCGCAGAGCCCAGATTTAGTTGCTC
CCAGGTCTTCATGGGGCAGGTGGGACTGTGGCTCTAGGGGAAACCCCCTGTCCAGCTGGGGTTGTTCTCCCCACCCACCTTCCACCCAGT
CTGCACCTGTCCTCACTCCCCCGGGCAGCTCTCCCACCAGGTCCTTCTGCCTGGGTGACGCGTGGCTGCTCCCAAGTTCTAAGACTCATT
ACTGGAATCACACCTCTCCCACATCTTCCAACACGCTTCACCCCCAACCCTACTTCCAGGGCGGGCTACTCCCTGCACAATGGGAGATGC
AGTGCTGGCACTGCCATCATTTGTCCCAGACCCATGCCCCTCCCCTCTCCTGCCCCATCCTGCGTCCTTGTCTAAGAAACCTCCACTAGC
AGCTGCTGCCTCTTCAGAGGCGAATCCCAGGCTGGAAGTATCCTAGCCAGGTCTGCCTGTGACGGCAGGGCCCACCCTCCCACCAGGCCT
GGGAGGCGGTAGGTGCCACCTCAGAGAGGGCCTGGCTGGCCCCATGACAAGAACAAGAAGTGCTAACTGGTACCAGAGTCCCCAGATAGA
GCTGCGAGGGCCCTCGCTGTGGGCGCGAGCTCCGGAGTAGCAGGCTGGATGGAGCATCCCTTCTACAGGGACACAGCCGCCTGCCAGCTG
GGCCTAAAGTCTGGAGCTTGTCTCTGAAAGGGACCGTCTGCTGCCCTCGCTGCCCCACTGGAGCCCTCAGGGCCTCCTACAGTGCAGGTG
GTCCTACTAGAGGGAAGCCATCCCCACCTGGCACCTCAGCGGCTTGGCAGTGACATGGCAGTGGGAGGGCTCTGAGGTTCCCACCCTGAC
AATGGTCAGGCTGCCCGTGCTCCCACTCCAACACTAAAAGCGGCTCCCTTAGGGGCTGAGCGTGGGTGCTCAGTGTTCACGCTATATCCC
TTGGGCAATGTGGGGTTGGATGGGGCCCCCACTTCCATTCCCATGGAAGGAGGCCAGGTCCCCAGCCACCTCCCACTCAGCCATGCACGC
ACTTGCTGGGCTGGCCTCCTGGGAAACACAGGTGACTCGAATGAACTCTGCATTTTCAACGTGCCTTCTACTGCTTCAGGACCTGGGGGT
CCCCCTGACCCTCACTGGCTTGCCCCCAGCCCTGGGCCTGGCCCCACCTGTCCTGGAGCCCAGAGCCCCTGGCCTGGAGCTACCTCTCTG
GGGTGGGTCTCAGGCCCCACCCCTCCCTCTTTTGAGTTCAGTGCCTTGCTCAGCCCCTCCCCTGTATCTCAGCGTCTTCAGACCTCTGAC
AGAGCGACGATGTAGGGTCTCCCGGGGCCCAAGGTGGTCTCAGGGTCAGGGGTGGGATTTGCAGGGAACTCGGGGAGCCCACGGGCTGCG
CCACCTCTGCCCTGGCAGCTGAAGCCTGGGAGAGTCCCTGCGTGGTGTAATTGGCCTCAGCCCGCTTTCTCTGTGCCGTCGCACCTCAGT
GTTTCTCATAGCTTGTCCCCACGTGTCACTTTCCATCCACGGGAAAAACAAATGCCCCTTCTCCATCTATCATTGCGACTTCCTCCCAGG
AGGCCTCTCAGGTTGGGTAGAGCAGGGGCCTGCAGTGGTCAGGCCAAGAGCAAGGAAGACCTGGCTGCCCCACTGTGGCTGAAAACTCAA
AACATCTGGAACTACCCTTCTCCAATTACGTTCCCTCTTGCTTAAAGACAAAGCTAATTAAATCATCCTGCCACCCGAGGCTCCAAACCA
AATCTTGGACGCAAATTCATTAGCTTCATAAAGCCCAGGTTGATTTATGTGACAGTCTGGAACCGCCCAGCCATGGAGTCGGTGGCCGTG
TTCCCTGCCCTGGAGGGAACTGGCCAGCAGTGACCACATCGCTGATGCCAAGTGGGGACCCTCACCACTGCCGTTGTCTAGCTGCTTTGC
TCCTCAGTGTCCTCCTGCTGTAAGTCAGATGAGGTCACCTTCCTCTCCATCGATGCCAGGCTTCTGCCGCTGACGGCCAATGGGGCTTGG
GGCCAGGGGCAGAGAACCCCAACAGCAAGAGAGCCCCAGGTGATGCTGGCTCTCCACGTGCATCCGGCACGTTTCACTGCAGCCATCATC
AACTTGGCAAAGTAGGCAAGCTCAGCTTGTGGTTTCCATTTTGCAGATGGGCCCCCGGGGTCAGTGATGGGAAGAGCAGAAGAGGATGCC
AGCCCAGCCTGGCCCAGGAGCAGGTGTCGTTGTGGAGGAAAGCTTAAACTCAACAGCCTCTACCCAACATCTGCCACCTGCATGGCCCCA
GATGCCCCCGGTGCAGGCCAGGTCAAGGTGGGAGTAAACTTTCTTTGCCTCCCTCCCCACAGAAGCACCAGACCCACCTGAGCCCCAGAG
CCTCATGCCAGCAGCTCCTGGCTGTTCCTCACCTGAGGCTAGAGCAGCAGCTGCCAGCTTATAGATGGGGCGGATGGCAGGTGATAGACT
GGGAAGCACTGCTGGGTGGTGGAGGTGGGCAGTGGCACCATGACGGGCCCCTAGCCACACAGCTGTCCTCACTACGGGGCAGGGAGCAGC
CTCGGCAACAGGCAAAGGCCAGAGTCAGAGTGGTGGGGAGGACAGGGGCTGCTGCCCCGCTCCTGGAAAGCCACTGCAGAGGGGCAGTGG
CTGGCAGTGCCAGGCCTGGGGGAAGTGGAAGCGTCCTGTCTGGGGGCAGATTCCCAAGCAAGGGTGACCCATGGTTAAGGGCCACTGGAA
AGCTGGAGAGAGCTTGGGATCCCTTCCACCTGGGGCCAATGGTGTTGATTGCAGACTGGAGGGGTAACCTCCGCTGAGGGTCATTATGTG
CCAGGCATGGCATTGGGTACTTTCTGCATTGGGACCAGGCAGCCGGGCCTGCCATTTGAGGCAGCGAGCCTCCGTGACCTGTCCTCCCTC
ATTTGTAAAGTGGGGTAACAGCTATGTCACTGGCCAGTTGTGGGGATTAAAGTGCTGAGCTTAGTGCCCAGCCCAAAATGCTCAATAAAG

>45705_45705_1_LLGL2-TMEM104_LLGL2_chr17_73567181_ENST00000167462_TMEM104_chr17_72832066_ENST00000335464_length(amino acids)=978AA_BP=726
MRRFLRPGHDPVRERLKRDLFQFNKTVEHGFPHQPSALGYSPSLRILAIGTRSGAIKLYGAPGVEFMGLHQENNAVTQIHLLPGQCQLVT
LLDDNSLHLWSLKVKGGASELQEDESFTLRGPPGAAPSATQITVVLPHSSCELLYLGTESGNVFVVQLPAFRALEDRTISSDAVLQRLPE
EARHRRVFEMVEALQEHPRDPNQILIGYSRGLVVIWDLQGSRVLYHFLSSQQLENIWWQRDGRLLVSCHSDGSYCQWPVSSEAQQPEPLR
SLVPYGPFPCKAITRILWLTTRQGLPFTIFQGGMPRASYGDRHCISVIHDGQQTAFDFTSRVIGFTVLTEADPAATFDDPYALVVLAEEE
LVVIDLQTAGWPPVQLPYLASLHCSAITCSHHVSNIPLKLWERIIAAGSRQNAHFSTMEWPIDGGTSLTPAPPQRDLLLTGHEDGTVRFW
DASGVCLRLLYKLSTVRVFLTDTDPNENFSAQGEDEWPPLRKVGSFDPYSDDPRLGIQKIFLCKYSGYLAVAGTAGQVLVLELNDEAAEQ
AVEQVEADLLQDQEGYRWKGHERLAARSGPVRFEPGFQPFVLVQCQPPAVVTSLALHSEWRLVAFGTSHGFGLFDHQQRRQVFVKCTLHP
SDQLALEGPLSRVKSLKKSLRQSFRRMRRSRVSSRKRHPAGPPGEAQEGSAKAERPGLQNMELAPVQRKIEARSAEDSFTGFVRTLYFAD
TYLKDTFAVMIVLALIRIGHGQGEGHPPLADFSGVRNLFGVCVYSFMCQHSLPSLITPVSSKRHLTRLVFLDYVLILAFYGLLSFTAIFC
FRGDSLMDMYTLNFARCDVVGLAAVRFFLGLFPVFTISTNFPIIAVTLRNNWKTLFHREGGTYPWVVDRVVFPTITLVPPVLVAFCTHDL

--------------------------------------------------------------
>45705_45705_2_LLGL2-TMEM104_LLGL2_chr17_73567181_ENST00000392550_TMEM104_chr17_72832066_ENST00000335464_length(transcript)=6146nt_BP=2293nt
GTGGGCAGGCGCGGCGGAGCGAGCGGGGCCGGCGGCGGGCGCCGAGGGACGCCGAGGCCTCGGGCGGGGGCTGGCCCGGGGTTCCAGGTC
TCCAGTGGGGGCTGCAGACTAAGCAAAATGAGGCGGTTCCTGAGGCCAGGGCATGACCCTGTGCGGGAGAGGCTCAAGCGGGACCTGTTC
CAGTTTAACAAGACGGTGGAGCATGGCTTCCCGCACCAGCCCAGCGCCCTCGGCTACAGCCCGTCCCTGCGCATCCTGGCCATCGGCACC
CGTTCTGGAGCCATCAAGCTCTACGGAGCCCCAGGCGTGGAGTTCATGGGGCTGCACCAGGAGAACAACGCTGTGACGCAGATCCACCTC
CTGCCCGGCCAGTGCCAGCTGGTCACCCTGCTGGATGACAACAGCCTGCACCTTTGGAGCCTGAAGGTCAAGGGCGGGGCATCGGAGCTG
CAGGAGGATGAGAGCTTCACACTGCGTGGACCCCCAGGGGCTGCCCCCAGTGCCACACAGATCACCGTGGTCCTGCCACATTCCTCCTGC
GAGCTGCTCTACCTGGGCACCGAGAGTGGCAACGTGTTTGTGGTGCAGCTGCCAGCTTTTCGTGCGCTGGAGGACCGGACCATCAGCTCG
GACGCGGTGCTGCAGCGGTTGCCAGAGGAGGCCCGCCACCGGCGTGTGTTCGAGATGGTGGAGGCACTGCAGGAGCACCCTCGAGACCCC
AACCAGATCCTGATCGGCTACAGCCGAGGCCTCGTTGTCATCTGGGACCTACAGGGCAGCCGCGTGCTCTACCACTTCCTCAGCAGCCAG
CAACTGGAGAACATCTGGTGGCAGCGGGACGGCCGCCTGCTCGTCAGCTGTCACTCTGACGGCAGCTACTGCCAGTGGCCCGTGTCCAGC
GAAGCCCAGCAACCAGAGCCCCTCCGCAGCCTCGTGCCTTACGGTCCCTTTCCTTGCAAAGCGATTACCAGAATCCTCTGGCTGACCACT
AGGCAGGGGTTGCCCTTCACCATCTTCCAGGGTGGCATGCCACGGGCCAGCTACGGGGACCGCCACTGCATCTCAGTGATCCACGATGGC
CAGCAGACGGCCTTCGACTTCACCTCCCGTGTCATCGGCTTCACTGTCCTCACAGAGGCAGACCCTGCAGCCACCTTTGACGACCCCTAT
GCCCTGGTGGTGCTGGCTGAGGAGGAGCTGGTGGTGATTGACCTGCAGACAGCAGGCTGGCCACCGGTCCAGCTGCCCTACCTGGCTTCT
CTGCACTGTTCCGCCATCACCTGCTCTCACCACGTCTCCAACATCCCGCTGAAGCTGTGGGAGCGGATCATTGCCGCCGGCAGCCGGCAG
AACGCACACTTCTCCACCATGGAGTGGCCAATTGATGGTGGCACCAGCCTGACCCCAGCCCCACCCCAGAGGGACCTGCTGCTCACAGGG
CACGAGGACGGCACGGTGCGGTTCTGGGATGCCTCGGGTGTCTGCCTGCGGCTGCTCTACAAACTCAGCACTGTGCGCGTGTTCCTCACC
GACACGGACCCCAACGAGAACTTCAGTGCCCAGGGCGAGGACGAGTGGCCCCCACTCCGCAAGGTGGGCTCCTTTGACCCCTACAGTGAT
GACCCCCGGCTGGGCATCCAGAAGATCTTCCTCTGCAAGTACAGCGGCTACCTGGCTGTGGCAGGCACGGCAGGGCAGGTGCTGGTACTG
GAACTGAATGACGAGGCAGCGGAGCAGGCTGTGGAGCAGGTGGAGGCCGACCTGCTGCAGGACCAAGAGGGCTACCGCTGGAAGGGGCAC
GAGCGCCTGGCAGCCCGCTCAGGGCCCGTGCGCTTTGAGCCTGGCTTTCAGCCCTTCGTGTTGGTGCAGTGTCAGCCCCCGGCTGTGGTC
ACCTCCTTGGCCCTGCACTCTGAGTGGCGGCTCGTGGCCTTCGGCACCAGCCATGGCTTTGGCCTCTTTGACCACCAGCAGCGGCGGCAG
GTCTTTGTTAAGTGCACACTGCACCCCAGTGACCAGCTGGCCTTGGAGGGCCCACTCTCCCGCGTCAAGTCCCTCAAGAAGTCCTTGCGT
CAGTCATTCCGCCGGATGCGTCGGAGCCGGGTGTCCAGCCGGAAGCGGCACCCGGCTGGCCCCCCAGGAGAGGCACAGGAGGGGAGTGCC
AAGGCTGAGCGGCCAGGCCTCCAGAACATGGAGCTGGCGCCTGTGCAGCGCAAGATCGAGGCTCGCTCGGCAGAGGACTCCTTCACAGGC
TTCGTCCGGACCCTGTACTTTGCTGACACCTACCTGAAGGACACTTTCGCCGTCATGATTGTGCTGGCCCTGATCCGCATCGGGCACGGA
CAAGGGGAGGGGCACCCGCCCCTGGCTGACTTCTCGGGGGTCCGGAACCTGTTTGGGGTGTGCGTCTACTCCTTCATGTGCCAGCACTCT
CTGCCATCCCTCATTACCCCCGTCTCCTCCAAGCGCCACCTCACAAGGCTGGTGTTCCTGGACTACGTGCTGATCCTGGCCTTCTACGGC
CTCCTCTCCTTCACCGCCATCTTCTGCTTCCGCGGCGACAGCCTCATGGACATGTACACCCTCAACTTCGCGCGCTGTGACGTCGTGGGC
CTGGCCGCTGTGCGCTTTTTCCTGGGCCTCTTCCCCGTCTTCACCATCAGCACCAACTTCCCCATCATTGCCGTGACCCTGCGCAACAAC
TGGAAGACACTCTTCCACCGCGAGGGCGGCACGTACCCGTGGGTGGTGGACCGCGTCGTGTTTCCCACCATCACCCTGGTGCCGCCTGTG
CTGGTGGCCTTCTGCACCCACGACCTGGAGTCCCTGGTGGGCATCACAGGGGCCTACGCGGGCACCGGCATCCAGTACGTCATCCCCGCC
TTCCTGGTGTACCACTGCCGCAGGGACACCCAGCTGGCCTTTGGCTGTGGGGTCAGCAACAAGCACAGGTCCCCTTTCCGCCACACCTTC
TGGGTGGGCTTCGTGCTGCTCTGGGCTTTCTCCTGCTTCATTTTCGTCACGGCCAATATCATCCTCAGCGAGACCAAGCTCTGATGGCAG
GACAGGCAGGTCTAGTGACAGGAGGCATAGGGGCCCCAGCCCCACCCCTCGCCCGCAGAGCCCAGATTTAGTTGCTCCCAGGTCTTCATG
GGGCAGGTGGGACTGTGGCTCTAGGGGAAACCCCCTGTCCAGCTGGGGTTGTTCTCCCCACCCACCTTCCACCCAGTCTGCACCTGTCCT
CACTCCCCCGGGCAGCTCTCCCACCAGGTCCTTCTGCCTGGGTGACGCGTGGCTGCTCCCAAGTTCTAAGACTCATTACTGGAATCACAC
CTCTCCCACATCTTCCAACACGCTTCACCCCCAACCCTACTTCCAGGGCGGGCTACTCCCTGCACAATGGGAGATGCAGTGCTGGCACTG
CCATCATTTGTCCCAGACCCATGCCCCTCCCCTCTCCTGCCCCATCCTGCGTCCTTGTCTAAGAAACCTCCACTAGCAGCTGCTGCCTCT
TCAGAGGCGAATCCCAGGCTGGAAGTATCCTAGCCAGGTCTGCCTGTGACGGCAGGGCCCACCCTCCCACCAGGCCTGGGAGGCGGTAGG
TGCCACCTCAGAGAGGGCCTGGCTGGCCCCATGACAAGAACAAGAAGTGCTAACTGGTACCAGAGTCCCCAGATAGAGCTGCGAGGGCCC
TCGCTGTGGGCGCGAGCTCCGGAGTAGCAGGCTGGATGGAGCATCCCTTCTACAGGGACACAGCCGCCTGCCAGCTGGGCCTAAAGTCTG
GAGCTTGTCTCTGAAAGGGACCGTCTGCTGCCCTCGCTGCCCCACTGGAGCCCTCAGGGCCTCCTACAGTGCAGGTGGTCCTACTAGAGG
GAAGCCATCCCCACCTGGCACCTCAGCGGCTTGGCAGTGACATGGCAGTGGGAGGGCTCTGAGGTTCCCACCCTGACAATGGTCAGGCTG
CCCGTGCTCCCACTCCAACACTAAAAGCGGCTCCCTTAGGGGCTGAGCGTGGGTGCTCAGTGTTCACGCTATATCCCTTGGGCAATGTGG
GGTTGGATGGGGCCCCCACTTCCATTCCCATGGAAGGAGGCCAGGTCCCCAGCCACCTCCCACTCAGCCATGCACGCACTTGCTGGGCTG
GCCTCCTGGGAAACACAGGTGACTCGAATGAACTCTGCATTTTCAACGTGCCTTCTACTGCTTCAGGACCTGGGGGTCCCCCTGACCCTC
ACTGGCTTGCCCCCAGCCCTGGGCCTGGCCCCACCTGTCCTGGAGCCCAGAGCCCCTGGCCTGGAGCTACCTCTCTGGGGTGGGTCTCAG
GCCCCACCCCTCCCTCTTTTGAGTTCAGTGCCTTGCTCAGCCCCTCCCCTGTATCTCAGCGTCTTCAGACCTCTGACAGAGCGACGATGT
AGGGTCTCCCGGGGCCCAAGGTGGTCTCAGGGTCAGGGGTGGGATTTGCAGGGAACTCGGGGAGCCCACGGGCTGCGCCACCTCTGCCCT
GGCAGCTGAAGCCTGGGAGAGTCCCTGCGTGGTGTAATTGGCCTCAGCCCGCTTTCTCTGTGCCGTCGCACCTCAGTGTTTCTCATAGCT
TGTCCCCACGTGTCACTTTCCATCCACGGGAAAAACAAATGCCCCTTCTCCATCTATCATTGCGACTTCCTCCCAGGAGGCCTCTCAGGT
TGGGTAGAGCAGGGGCCTGCAGTGGTCAGGCCAAGAGCAAGGAAGACCTGGCTGCCCCACTGTGGCTGAAAACTCAAAACATCTGGAACT
ACCCTTCTCCAATTACGTTCCCTCTTGCTTAAAGACAAAGCTAATTAAATCATCCTGCCACCCGAGGCTCCAAACCAAATCTTGGACGCA
AATTCATTAGCTTCATAAAGCCCAGGTTGATTTATGTGACAGTCTGGAACCGCCCAGCCATGGAGTCGGTGGCCGTGTTCCCTGCCCTGG
AGGGAACTGGCCAGCAGTGACCACATCGCTGATGCCAAGTGGGGACCCTCACCACTGCCGTTGTCTAGCTGCTTTGCTCCTCAGTGTCCT
CCTGCTGTAAGTCAGATGAGGTCACCTTCCTCTCCATCGATGCCAGGCTTCTGCCGCTGACGGCCAATGGGGCTTGGGGCCAGGGGCAGA
GAACCCCAACAGCAAGAGAGCCCCAGGTGATGCTGGCTCTCCACGTGCATCCGGCACGTTTCACTGCAGCCATCATCAACTTGGCAAAGT
AGGCAAGCTCAGCTTGTGGTTTCCATTTTGCAGATGGGCCCCCGGGGTCAGTGATGGGAAGAGCAGAAGAGGATGCCAGCCCAGCCTGGC
CCAGGAGCAGGTGTCGTTGTGGAGGAAAGCTTAAACTCAACAGCCTCTACCCAACATCTGCCACCTGCATGGCCCCAGATGCCCCCGGTG
CAGGCCAGGTCAAGGTGGGAGTAAACTTTCTTTGCCTCCCTCCCCACAGAAGCACCAGACCCACCTGAGCCCCAGAGCCTCATGCCAGCA
GCTCCTGGCTGTTCCTCACCTGAGGCTAGAGCAGCAGCTGCCAGCTTATAGATGGGGCGGATGGCAGGTGATAGACTGGGAAGCACTGCT
GGGTGGTGGAGGTGGGCAGTGGCACCATGACGGGCCCCTAGCCACACAGCTGTCCTCACTACGGGGCAGGGAGCAGCCTCGGCAACAGGC
AAAGGCCAGAGTCAGAGTGGTGGGGAGGACAGGGGCTGCTGCCCCGCTCCTGGAAAGCCACTGCAGAGGGGCAGTGGCTGGCAGTGCCAG
GCCTGGGGGAAGTGGAAGCGTCCTGTCTGGGGGCAGATTCCCAAGCAAGGGTGACCCATGGTTAAGGGCCACTGGAAAGCTGGAGAGAGC
TTGGGATCCCTTCCACCTGGGGCCAATGGTGTTGATTGCAGACTGGAGGGGTAACCTCCGCTGAGGGTCATTATGTGCCAGGCATGGCAT
TGGGTACTTTCTGCATTGGGACCAGGCAGCCGGGCCTGCCATTTGAGGCAGCGAGCCTCCGTGACCTGTCCTCCCTCATTTGTAAAGTGG
GGTAACAGCTATGTCACTGGCCAGTTGTGGGGATTAAAGTGCTGAGCTTAGTGCCCAGCCCAAAATGCTCAATAAAGCTATTCAGTGATA

>45705_45705_2_LLGL2-TMEM104_LLGL2_chr17_73567181_ENST00000392550_TMEM104_chr17_72832066_ENST00000335464_length(amino acids)=978AA_BP=726
MRRFLRPGHDPVRERLKRDLFQFNKTVEHGFPHQPSALGYSPSLRILAIGTRSGAIKLYGAPGVEFMGLHQENNAVTQIHLLPGQCQLVT
LLDDNSLHLWSLKVKGGASELQEDESFTLRGPPGAAPSATQITVVLPHSSCELLYLGTESGNVFVVQLPAFRALEDRTISSDAVLQRLPE
EARHRRVFEMVEALQEHPRDPNQILIGYSRGLVVIWDLQGSRVLYHFLSSQQLENIWWQRDGRLLVSCHSDGSYCQWPVSSEAQQPEPLR
SLVPYGPFPCKAITRILWLTTRQGLPFTIFQGGMPRASYGDRHCISVIHDGQQTAFDFTSRVIGFTVLTEADPAATFDDPYALVVLAEEE
LVVIDLQTAGWPPVQLPYLASLHCSAITCSHHVSNIPLKLWERIIAAGSRQNAHFSTMEWPIDGGTSLTPAPPQRDLLLTGHEDGTVRFW
DASGVCLRLLYKLSTVRVFLTDTDPNENFSAQGEDEWPPLRKVGSFDPYSDDPRLGIQKIFLCKYSGYLAVAGTAGQVLVLELNDEAAEQ
AVEQVEADLLQDQEGYRWKGHERLAARSGPVRFEPGFQPFVLVQCQPPAVVTSLALHSEWRLVAFGTSHGFGLFDHQQRRQVFVKCTLHP
SDQLALEGPLSRVKSLKKSLRQSFRRMRRSRVSSRKRHPAGPPGEAQEGSAKAERPGLQNMELAPVQRKIEARSAEDSFTGFVRTLYFAD
TYLKDTFAVMIVLALIRIGHGQGEGHPPLADFSGVRNLFGVCVYSFMCQHSLPSLITPVSSKRHLTRLVFLDYVLILAFYGLLSFTAIFC
FRGDSLMDMYTLNFARCDVVGLAAVRFFLGLFPVFTISTNFPIIAVTLRNNWKTLFHREGGTYPWVVDRVVFPTITLVPPVLVAFCTHDL

--------------------------------------------------------------
>45705_45705_3_LLGL2-TMEM104_LLGL2_chr17_73567181_ENST00000577200_TMEM104_chr17_72832066_ENST00000335464_length(transcript)=6133nt_BP=2280nt
GGCTCACTGCAACCTCTGCCTCCCGGGTTCAAGCAATTCTCCTGCCTCGGCCTCCTGAGTAGCTGGGATTACAGGTCTCCAGTGGGGGCT
GCAGACTAAGCAAAATGAGGCGGTTCCTGAGGCCAGGGCATGACCCTGTGCGGGAGAGGCTCAAGCGGGACCTGTTCCAGTTTAACAAGA
CGGTGGAGCATGGCTTCCCGCACCAGCCCAGCGCCCTCGGCTACAGCCCGTCCCTGCGCATCCTGGCCATCGGCACCCGTTCTGGAGCCA
TCAAGCTCTACGGAGCCCCAGGCGTGGAGTTCATGGGGCTGCACCAGGAGAACAACGCTGTGACGCAGATCCACCTCCTGCCCGGCCAGT
GCCAGCTGGTCACCCTGCTGGATGACAACAGCCTGCACCTTTGGAGCCTGAAGGTCAAGGGCGGGGCATCGGAGCTGCAGGAGGATGAGA
GCTTCACACTGCGTGGACCCCCAGGGGCTGCCCCCAGTGCCACACAGATCACCGTGGTCCTGCCACATTCCTCCTGCGAGCTGCTCTACC
TGGGCACCGAGAGTGGCAACGTGTTTGTGGTGCAGCTGCCAGCTTTTCGTGCGCTGGAGGACCGGACCATCAGCTCGGACGCGGTGCTGC
AGCGGTTGCCAGAGGAGGCCCGCCACCGGCGTGTGTTCGAGATGGTGGAGGCACTGCAGGAGCACCCTCGAGACCCCAACCAGATCCTGA
TCGGCTACAGCCGAGGCCTCGTTGTCATCTGGGACCTACAGGGCAGCCGCGTGCTCTACCACTTCCTCAGCAGCCAGCAACTGGAGAACA
TCTGGTGGCAGCGGGACGGCCGCCTGCTCGTCAGCTGTCACTCTGACGGCAGCTACTGCCAGTGGCCCGTGTCCAGCGAAGCCCAGCAAC
CAGAGCCCCTCCGCAGCCTCGTGCCTTACGGTCCCTTTCCTTGCAAAGCGATTACCAGAATCCTCTGGCTGACCACTAGGCAGGGGTTGC
CCTTCACCATCTTCCAGGGTGGCATGCCACGGGCCAGCTACGGGGACCGCCACTGCATCTCAGTGATCCACGATGGCCAGCAGACGGCCT
TCGACTTCACCTCCCGTGTCATCGGCTTCACTGTCCTCACAGAGGCAGACCCTGCAGCCACCTTTGACGACCCCTATGCCCTGGTGGTGC
TGGCTGAGGAGGAGCTGGTGGTGATTGACCTGCAGACAGCAGGCTGGCCACCGGTCCAGCTGCCCTACCTGGCTTCTCTGCACTGTTCCG
CCATCACCTGCTCTCACCACGTCTCCAACATCCCGCTGAAGCTGTGGGAGCGGATCATTGCCGCCGGCAGCCGGCAGAACGCACACTTCT
CCACCATGGAGTGGCCAATTGATGGTGGCACCAGCCTGACCCCAGCCCCACCCCAGAGGGACCTGCTGCTCACAGGGCACGAGGACGGCA
CGGTGCGGTTCTGGGATGCCTCGGGTGTCTGCCTGCGGCTGCTCTACAAACTCAGCACTGTGCGCGTGTTCCTCACCGACACGGACCCCA
ACGAGAACTTCAGTGCCCAGGGCGAGGACGAGTGGCCCCCACTCCGCAAGGTGGGCTCCTTTGACCCCTACAGTGATGACCCCCGGCTGG
GCATCCAGAAGATCTTCCTCTGCAAGTACAGCGGCTACCTGGCTGTGGCAGGCACGGCAGGGCAGGTGCTGGTACTGGAACTGAATGACG
AGGCAGCGGAGCAGGCTGTGGAGCAGGTGGAGGCCGACCTGCTGCAGGACCAAGAGGGCTACCGCTGGAAGGGGCACGAGCGCCTGGCAG
CCCGCTCAGGGCCCGTGCGCTTTGAGCCTGGCTTTCAGCCCTTCGTGTTGGTGCAGTGTCAGCCCCCGGCTGTGGTCACCTCCTTGGCCC
TGCACTCTGAGTGGCGGCTCGTGGCCTTCGGCACCAGCCATGGCTTTGGCCTCTTTGACCACCAGCAGCGGCGGCAGGTCTTTGTTAAGT
GCACACTGCACCCCAGTGACCAGCTGGCCTTGGAGGGCCCACTCTCCCGCGTCAAGTCCCTCAAGAAGTCCTTGCGTCAGTCATTCCGCC
GGATGCGTCGGAGCCGGGTGTCCAGCCGGAAGCGGCACCCGGCTGGCCCCCCAGGAGAGGCACAGGAGGGGAGTGCCAAGGCTGAGCGGC
CAGGCCTCCAGAACATGGAGCTGGCGCCTGTGCAGCGCAAGATCGAGGCTCGCTCGGCAGAGGACTCCTTCACAGGCTTCGTCCGGACCC
TGTACTTTGCTGACACCTACCTGAAGGACACTTTCGCCGTCATGATTGTGCTGGCCCTGATCCGCATCGGGCACGGACAAGGGGAGGGGC
ACCCGCCCCTGGCTGACTTCTCGGGGGTCCGGAACCTGTTTGGGGTGTGCGTCTACTCCTTCATGTGCCAGCACTCTCTGCCATCCCTCA
TTACCCCCGTCTCCTCCAAGCGCCACCTCACAAGGCTGGTGTTCCTGGACTACGTGCTGATCCTGGCCTTCTACGGCCTCCTCTCCTTCA
CCGCCATCTTCTGCTTCCGCGGCGACAGCCTCATGGACATGTACACCCTCAACTTCGCGCGCTGTGACGTCGTGGGCCTGGCCGCTGTGC
GCTTTTTCCTGGGCCTCTTCCCCGTCTTCACCATCAGCACCAACTTCCCCATCATTGCCGTGACCCTGCGCAACAACTGGAAGACACTCT
TCCACCGCGAGGGCGGCACGTACCCGTGGGTGGTGGACCGCGTCGTGTTTCCCACCATCACCCTGGTGCCGCCTGTGCTGGTGGCCTTCT
GCACCCACGACCTGGAGTCCCTGGTGGGCATCACAGGGGCCTACGCGGGCACCGGCATCCAGTACGTCATCCCCGCCTTCCTGGTGTACC
ACTGCCGCAGGGACACCCAGCTGGCCTTTGGCTGTGGGGTCAGCAACAAGCACAGGTCCCCTTTCCGCCACACCTTCTGGGTGGGCTTCG
TGCTGCTCTGGGCTTTCTCCTGCTTCATTTTCGTCACGGCCAATATCATCCTCAGCGAGACCAAGCTCTGATGGCAGGACAGGCAGGTCT
AGTGACAGGAGGCATAGGGGCCCCAGCCCCACCCCTCGCCCGCAGAGCCCAGATTTAGTTGCTCCCAGGTCTTCATGGGGCAGGTGGGAC
TGTGGCTCTAGGGGAAACCCCCTGTCCAGCTGGGGTTGTTCTCCCCACCCACCTTCCACCCAGTCTGCACCTGTCCTCACTCCCCCGGGC
AGCTCTCCCACCAGGTCCTTCTGCCTGGGTGACGCGTGGCTGCTCCCAAGTTCTAAGACTCATTACTGGAATCACACCTCTCCCACATCT
TCCAACACGCTTCACCCCCAACCCTACTTCCAGGGCGGGCTACTCCCTGCACAATGGGAGATGCAGTGCTGGCACTGCCATCATTTGTCC
CAGACCCATGCCCCTCCCCTCTCCTGCCCCATCCTGCGTCCTTGTCTAAGAAACCTCCACTAGCAGCTGCTGCCTCTTCAGAGGCGAATC
CCAGGCTGGAAGTATCCTAGCCAGGTCTGCCTGTGACGGCAGGGCCCACCCTCCCACCAGGCCTGGGAGGCGGTAGGTGCCACCTCAGAG
AGGGCCTGGCTGGCCCCATGACAAGAACAAGAAGTGCTAACTGGTACCAGAGTCCCCAGATAGAGCTGCGAGGGCCCTCGCTGTGGGCGC
GAGCTCCGGAGTAGCAGGCTGGATGGAGCATCCCTTCTACAGGGACACAGCCGCCTGCCAGCTGGGCCTAAAGTCTGGAGCTTGTCTCTG
AAAGGGACCGTCTGCTGCCCTCGCTGCCCCACTGGAGCCCTCAGGGCCTCCTACAGTGCAGGTGGTCCTACTAGAGGGAAGCCATCCCCA
CCTGGCACCTCAGCGGCTTGGCAGTGACATGGCAGTGGGAGGGCTCTGAGGTTCCCACCCTGACAATGGTCAGGCTGCCCGTGCTCCCAC
TCCAACACTAAAAGCGGCTCCCTTAGGGGCTGAGCGTGGGTGCTCAGTGTTCACGCTATATCCCTTGGGCAATGTGGGGTTGGATGGGGC
CCCCACTTCCATTCCCATGGAAGGAGGCCAGGTCCCCAGCCACCTCCCACTCAGCCATGCACGCACTTGCTGGGCTGGCCTCCTGGGAAA
CACAGGTGACTCGAATGAACTCTGCATTTTCAACGTGCCTTCTACTGCTTCAGGACCTGGGGGTCCCCCTGACCCTCACTGGCTTGCCCC
CAGCCCTGGGCCTGGCCCCACCTGTCCTGGAGCCCAGAGCCCCTGGCCTGGAGCTACCTCTCTGGGGTGGGTCTCAGGCCCCACCCCTCC
CTCTTTTGAGTTCAGTGCCTTGCTCAGCCCCTCCCCTGTATCTCAGCGTCTTCAGACCTCTGACAGAGCGACGATGTAGGGTCTCCCGGG
GCCCAAGGTGGTCTCAGGGTCAGGGGTGGGATTTGCAGGGAACTCGGGGAGCCCACGGGCTGCGCCACCTCTGCCCTGGCAGCTGAAGCC
TGGGAGAGTCCCTGCGTGGTGTAATTGGCCTCAGCCCGCTTTCTCTGTGCCGTCGCACCTCAGTGTTTCTCATAGCTTGTCCCCACGTGT
CACTTTCCATCCACGGGAAAAACAAATGCCCCTTCTCCATCTATCATTGCGACTTCCTCCCAGGAGGCCTCTCAGGTTGGGTAGAGCAGG
GGCCTGCAGTGGTCAGGCCAAGAGCAAGGAAGACCTGGCTGCCCCACTGTGGCTGAAAACTCAAAACATCTGGAACTACCCTTCTCCAAT
TACGTTCCCTCTTGCTTAAAGACAAAGCTAATTAAATCATCCTGCCACCCGAGGCTCCAAACCAAATCTTGGACGCAAATTCATTAGCTT
CATAAAGCCCAGGTTGATTTATGTGACAGTCTGGAACCGCCCAGCCATGGAGTCGGTGGCCGTGTTCCCTGCCCTGGAGGGAACTGGCCA
GCAGTGACCACATCGCTGATGCCAAGTGGGGACCCTCACCACTGCCGTTGTCTAGCTGCTTTGCTCCTCAGTGTCCTCCTGCTGTAAGTC
AGATGAGGTCACCTTCCTCTCCATCGATGCCAGGCTTCTGCCGCTGACGGCCAATGGGGCTTGGGGCCAGGGGCAGAGAACCCCAACAGC
AAGAGAGCCCCAGGTGATGCTGGCTCTCCACGTGCATCCGGCACGTTTCACTGCAGCCATCATCAACTTGGCAAAGTAGGCAAGCTCAGC
TTGTGGTTTCCATTTTGCAGATGGGCCCCCGGGGTCAGTGATGGGAAGAGCAGAAGAGGATGCCAGCCCAGCCTGGCCCAGGAGCAGGTG
TCGTTGTGGAGGAAAGCTTAAACTCAACAGCCTCTACCCAACATCTGCCACCTGCATGGCCCCAGATGCCCCCGGTGCAGGCCAGGTCAA
GGTGGGAGTAAACTTTCTTTGCCTCCCTCCCCACAGAAGCACCAGACCCACCTGAGCCCCAGAGCCTCATGCCAGCAGCTCCTGGCTGTT
CCTCACCTGAGGCTAGAGCAGCAGCTGCCAGCTTATAGATGGGGCGGATGGCAGGTGATAGACTGGGAAGCACTGCTGGGTGGTGGAGGT
GGGCAGTGGCACCATGACGGGCCCCTAGCCACACAGCTGTCCTCACTACGGGGCAGGGAGCAGCCTCGGCAACAGGCAAAGGCCAGAGTC
AGAGTGGTGGGGAGGACAGGGGCTGCTGCCCCGCTCCTGGAAAGCCACTGCAGAGGGGCAGTGGCTGGCAGTGCCAGGCCTGGGGGAAGT
GGAAGCGTCCTGTCTGGGGGCAGATTCCCAAGCAAGGGTGACCCATGGTTAAGGGCCACTGGAAAGCTGGAGAGAGCTTGGGATCCCTTC
CACCTGGGGCCAATGGTGTTGATTGCAGACTGGAGGGGTAACCTCCGCTGAGGGTCATTATGTGCCAGGCATGGCATTGGGTACTTTCTG
CATTGGGACCAGGCAGCCGGGCCTGCCATTTGAGGCAGCGAGCCTCCGTGACCTGTCCTCCCTCATTTGTAAAGTGGGGTAACAGCTATG
TCACTGGCCAGTTGTGGGGATTAAAGTGCTGAGCTTAGTGCCCAGCCCAAAATGCTCAATAAAGCTATTCAGTGATACCTGTTTCCCACA

>45705_45705_3_LLGL2-TMEM104_LLGL2_chr17_73567181_ENST00000577200_TMEM104_chr17_72832066_ENST00000335464_length(amino acids)=992AA_BP=740
MGLQVSSGGCRLSKMRRFLRPGHDPVRERLKRDLFQFNKTVEHGFPHQPSALGYSPSLRILAIGTRSGAIKLYGAPGVEFMGLHQENNAV
TQIHLLPGQCQLVTLLDDNSLHLWSLKVKGGASELQEDESFTLRGPPGAAPSATQITVVLPHSSCELLYLGTESGNVFVVQLPAFRALED
RTISSDAVLQRLPEEARHRRVFEMVEALQEHPRDPNQILIGYSRGLVVIWDLQGSRVLYHFLSSQQLENIWWQRDGRLLVSCHSDGSYCQ
WPVSSEAQQPEPLRSLVPYGPFPCKAITRILWLTTRQGLPFTIFQGGMPRASYGDRHCISVIHDGQQTAFDFTSRVIGFTVLTEADPAAT
FDDPYALVVLAEEELVVIDLQTAGWPPVQLPYLASLHCSAITCSHHVSNIPLKLWERIIAAGSRQNAHFSTMEWPIDGGTSLTPAPPQRD
LLLTGHEDGTVRFWDASGVCLRLLYKLSTVRVFLTDTDPNENFSAQGEDEWPPLRKVGSFDPYSDDPRLGIQKIFLCKYSGYLAVAGTAG
QVLVLELNDEAAEQAVEQVEADLLQDQEGYRWKGHERLAARSGPVRFEPGFQPFVLVQCQPPAVVTSLALHSEWRLVAFGTSHGFGLFDH
QQRRQVFVKCTLHPSDQLALEGPLSRVKSLKKSLRQSFRRMRRSRVSSRKRHPAGPPGEAQEGSAKAERPGLQNMELAPVQRKIEARSAE
DSFTGFVRTLYFADTYLKDTFAVMIVLALIRIGHGQGEGHPPLADFSGVRNLFGVCVYSFMCQHSLPSLITPVSSKRHLTRLVFLDYVLI
LAFYGLLSFTAIFCFRGDSLMDMYTLNFARCDVVGLAAVRFFLGLFPVFTISTNFPIIAVTLRNNWKTLFHREGGTYPWVVDRVVFPTIT
LVPPVLVAFCTHDLESLVGITGAYAGTGIQYVIPAFLVYHCRRDTQLAFGCGVSNKHRSPFRHTFWVGFVLLWAFSCFIFVTANIILSET

--------------------------------------------------------------

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Fusion Gene PPI Analysis for LLGL2-TMEM104


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for LLGL2-TMEM104


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for LLGL2-TMEM104


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource