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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:LLGL2-XRCC1 (FusionGDB2 ID:45707)

Fusion Gene Summary for LLGL2-XRCC1

check button Fusion gene summary
Fusion gene informationFusion gene name: LLGL2-XRCC1
Fusion gene ID: 45707
HgeneTgene
Gene symbol

LLGL2

XRCC1

Gene ID

3993

7515

Gene nameLLGL scribble cell polarity complex component 2X-ray repair cross complementing 1
SynonymsHGL|Hugl-2|LGL2RCC|SCAR26
Cytomap

17q25.1

19q13.31

Type of geneprotein-codingprotein-coding
DescriptionLLGL scribble cell polarity complex component 2LLGL2, scribble cell polarity complex componenthuman giant larvae homologlethal giant larvae homolog 2, scribble cell polarity complex componentlethal(2) giant larvae protein homolog 2DNA repair protein XRCC1X-ray repair complementing defective repair in Chinese hamster cells 1X-ray repair cross-complementing protein 1
Modification date2020032020200329
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000167462, ENST00000392550, 
ENST00000577200, ENST00000375227, 
ENST00000578363, 		ENST00000262887, 
ENST00000543982, 
Fusion gene scores* DoF score17 X 14 X 10=23804 X 4 X 4=64
# samples 205
** MAII scorelog2(20/2380*10)=-3.57288966842058
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/64*10)=-0.356143810225275
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: LLGL2 [Title/Abstract] AND XRCC1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointLLGL2(73565165)-XRCC1(44057048), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneLLGL2

GO:0032878

regulation of establishment or maintenance of cell polarity

12725730

TgeneXRCC1

GO:0033194

response to hydroperoxide

28002403


check buttonFusion gene breakpoints across LLGL2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across XRCC1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ABG979482LLGL2chr17

73565165

+XRCC1chr19

44057048

-


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Fusion Gene ORF analysis for LLGL2-XRCC1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000167462ENST00000262887LLGL2chr17

73565165

+XRCC1chr19

44057048

-
In-frameENST00000167462ENST00000543982LLGL2chr17

73565165

+XRCC1chr19

44057048

-
In-frameENST00000392550ENST00000262887LLGL2chr17

73565165

+XRCC1chr19

44057048

-
In-frameENST00000392550ENST00000543982LLGL2chr17

73565165

+XRCC1chr19

44057048

-
In-frameENST00000577200ENST00000262887LLGL2chr17

73565165

+XRCC1chr19

44057048

-
In-frameENST00000577200ENST00000543982LLGL2chr17

73565165

+XRCC1chr19

44057048

-
intron-3CDSENST00000375227ENST00000262887LLGL2chr17

73565165

+XRCC1chr19

44057048

-
intron-3CDSENST00000375227ENST00000543982LLGL2chr17

73565165

+XRCC1chr19

44057048

-
intron-3CDSENST00000578363ENST00000262887LLGL2chr17

73565165

+XRCC1chr19

44057048

-
intron-3CDSENST00000578363ENST00000543982LLGL2chr17

73565165

+XRCC1chr19

44057048

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000167462LLGL2chr1773565165+ENST00000262887XRCC1chr1944057048-303014991301560476
ENST00000167462LLGL2chr1773565165+ENST00000543982XRCC1chr1944057048-275814991301560476
ENST00000392550LLGL2chr1773565165+ENST00000262887XRCC1chr1944057048-301714861171547476
ENST00000392550LLGL2chr1773565165+ENST00000543982XRCC1chr1944057048-274514861171547476
ENST00000577200LLGL2chr1773565165+ENST00000262887XRCC1chr1944057048-30041473621534490
ENST00000577200LLGL2chr1773565165+ENST00000543982XRCC1chr1944057048-27321473621534490

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000167462ENST00000262887LLGL2chr1773565165+XRCC1chr1944057048-0.176361440.82363856
ENST00000167462ENST00000543982LLGL2chr1773565165+XRCC1chr1944057048-0.182867450.8171326
ENST00000392550ENST00000262887LLGL2chr1773565165+XRCC1chr1944057048-0.174275090.8257249
ENST00000392550ENST00000543982LLGL2chr1773565165+XRCC1chr1944057048-0.181658580.8183414
ENST00000577200ENST00000262887LLGL2chr1773565165+XRCC1chr1944057048-0.179114040.82088596
ENST00000577200ENST00000543982LLGL2chr1773565165+XRCC1chr1944057048-0.186664570.8133354

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Fusion Genomic Features for LLGL2-XRCC1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for LLGL2-XRCC1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:73565165/chr19:44057048)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneXRCC1chr17:73565165chr19:44057048ENST00000262887017315_4030634.0DomainBRCT 1
TgeneXRCC1chr17:73565165chr19:44057048ENST00000262887017538_6290634.0DomainBRCT 2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLLGL2chr17:73565165chr19:44057048ENST00000167462+125132_16901016.0RepeatNote=WD 3
HgeneLLGL2chr17:73565165chr19:44057048ENST00000167462+125193_22701016.0RepeatNote=WD 4
HgeneLLGL2chr17:73565165chr19:44057048ENST00000167462+125233_26801016.0RepeatNote=WD 5
HgeneLLGL2chr17:73565165chr19:44057048ENST00000167462+125282_32401016.0RepeatNote=WD 6
HgeneLLGL2chr17:73565165chr19:44057048ENST00000167462+125332_36601016.0RepeatNote=WD 7
HgeneLLGL2chr17:73565165chr19:44057048ENST00000167462+12536_6901016.0RepeatNote=WD 1
HgeneLLGL2chr17:73565165chr19:44057048ENST00000167462+125388_46401016.0RepeatNote=WD 8
HgeneLLGL2chr17:73565165chr19:44057048ENST00000167462+125508_58301016.0RepeatNote=WD 9
HgeneLLGL2chr17:73565165chr19:44057048ENST00000167462+125592_65301016.0RepeatNote=WD 10
HgeneLLGL2chr17:73565165chr19:44057048ENST00000167462+125713_76901016.0RepeatNote=WD 11
HgeneLLGL2chr17:73565165chr19:44057048ENST00000167462+12576_11701016.0RepeatNote=WD 2
HgeneLLGL2chr17:73565165chr19:44057048ENST00000167462+125778_83001016.0RepeatNote=WD 12
HgeneLLGL2chr17:73565165chr19:44057048ENST00000167462+125835_88801016.0RepeatNote=WD 13
HgeneLLGL2chr17:73565165chr19:44057048ENST00000167462+125902_92501016.0RepeatNote=WD 14
HgeneLLGL2chr17:73565165chr19:44057048ENST00000375227+110132_1690357.0RepeatNote=WD 3
HgeneLLGL2chr17:73565165chr19:44057048ENST00000375227+110193_2270357.0RepeatNote=WD 4
HgeneLLGL2chr17:73565165chr19:44057048ENST00000375227+110233_2680357.0RepeatNote=WD 5
HgeneLLGL2chr17:73565165chr19:44057048ENST00000375227+110282_3240357.0RepeatNote=WD 6
HgeneLLGL2chr17:73565165chr19:44057048ENST00000375227+110332_3660357.0RepeatNote=WD 7
HgeneLLGL2chr17:73565165chr19:44057048ENST00000375227+11036_690357.0RepeatNote=WD 1
HgeneLLGL2chr17:73565165chr19:44057048ENST00000375227+110388_4640357.0RepeatNote=WD 8
HgeneLLGL2chr17:73565165chr19:44057048ENST00000375227+110508_5830357.0RepeatNote=WD 9
HgeneLLGL2chr17:73565165chr19:44057048ENST00000375227+110592_6530357.0RepeatNote=WD 10
HgeneLLGL2chr17:73565165chr19:44057048ENST00000375227+110713_7690357.0RepeatNote=WD 11
HgeneLLGL2chr17:73565165chr19:44057048ENST00000375227+11076_1170357.0RepeatNote=WD 2
HgeneLLGL2chr17:73565165chr19:44057048ENST00000375227+110778_8300357.0RepeatNote=WD 12
HgeneLLGL2chr17:73565165chr19:44057048ENST00000375227+110835_8880357.0RepeatNote=WD 13
HgeneLLGL2chr17:73565165chr19:44057048ENST00000375227+110902_9250357.0RepeatNote=WD 14
HgeneLLGL2chr17:73565165chr19:44057048ENST00000392550+126132_16901021.0RepeatNote=WD 3
HgeneLLGL2chr17:73565165chr19:44057048ENST00000392550+126193_22701021.0RepeatNote=WD 4
HgeneLLGL2chr17:73565165chr19:44057048ENST00000392550+126233_26801021.0RepeatNote=WD 5
HgeneLLGL2chr17:73565165chr19:44057048ENST00000392550+126282_32401021.0RepeatNote=WD 6
HgeneLLGL2chr17:73565165chr19:44057048ENST00000392550+126332_36601021.0RepeatNote=WD 7
HgeneLLGL2chr17:73565165chr19:44057048ENST00000392550+12636_6901021.0RepeatNote=WD 1
HgeneLLGL2chr17:73565165chr19:44057048ENST00000392550+126388_46401021.0RepeatNote=WD 8
HgeneLLGL2chr17:73565165chr19:44057048ENST00000392550+126508_58301021.0RepeatNote=WD 9
HgeneLLGL2chr17:73565165chr19:44057048ENST00000392550+126592_65301021.0RepeatNote=WD 10
HgeneLLGL2chr17:73565165chr19:44057048ENST00000392550+126713_76901021.0RepeatNote=WD 11
HgeneLLGL2chr17:73565165chr19:44057048ENST00000392550+12676_11701021.0RepeatNote=WD 2
HgeneLLGL2chr17:73565165chr19:44057048ENST00000392550+126778_83001021.0RepeatNote=WD 12
HgeneLLGL2chr17:73565165chr19:44057048ENST00000392550+126835_88801021.0RepeatNote=WD 13
HgeneLLGL2chr17:73565165chr19:44057048ENST00000392550+126902_92501021.0RepeatNote=WD 14
HgeneLLGL2chr17:73565165chr19:44057048ENST00000578363+111132_1690357.0RepeatNote=WD 3
HgeneLLGL2chr17:73565165chr19:44057048ENST00000578363+111193_2270357.0RepeatNote=WD 4
HgeneLLGL2chr17:73565165chr19:44057048ENST00000578363+111233_2680357.0RepeatNote=WD 5
HgeneLLGL2chr17:73565165chr19:44057048ENST00000578363+111282_3240357.0RepeatNote=WD 6
HgeneLLGL2chr17:73565165chr19:44057048ENST00000578363+111332_3660357.0RepeatNote=WD 7
HgeneLLGL2chr17:73565165chr19:44057048ENST00000578363+11136_690357.0RepeatNote=WD 1
HgeneLLGL2chr17:73565165chr19:44057048ENST00000578363+111388_4640357.0RepeatNote=WD 8
HgeneLLGL2chr17:73565165chr19:44057048ENST00000578363+111508_5830357.0RepeatNote=WD 9
HgeneLLGL2chr17:73565165chr19:44057048ENST00000578363+111592_6530357.0RepeatNote=WD 10
HgeneLLGL2chr17:73565165chr19:44057048ENST00000578363+111713_7690357.0RepeatNote=WD 11
HgeneLLGL2chr17:73565165chr19:44057048ENST00000578363+11176_1170357.0RepeatNote=WD 2
HgeneLLGL2chr17:73565165chr19:44057048ENST00000578363+111778_8300357.0RepeatNote=WD 12
HgeneLLGL2chr17:73565165chr19:44057048ENST00000578363+111835_8880357.0RepeatNote=WD 13
HgeneLLGL2chr17:73565165chr19:44057048ENST00000578363+111902_9250357.0RepeatNote=WD 14


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Fusion Gene Sequence for LLGL2-XRCC1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>45707_45707_1_LLGL2-XRCC1_LLGL2_chr17_73565165_ENST00000167462_XRCC1_chr19_44057048_ENST00000262887_length(transcript)=3030nt_BP=1499nt
CGCCCAGCAGCCCGTGGGCAGGCGCGGCGGAGCGAGCGGGGCCGGCGGCGGGCGCCGAGGGACGCCGAGGCCTCGGGCGGGGGCTGGCCC
GGGGTTCCAGGTCTCCAGTGGGGGCTGCAGACTAAGCAAAATGAGGCGGTTCCTGAGGCCAGGGCATGACCCTGTGCGGGAGAGGCTCAA
GCGGGACCTGTTCCAGTTTAACAAGACGGTGGAGCATGGCTTCCCGCACCAGCCCAGCGCCCTCGGCTACAGCCCGTCCCTGCGCATCCT
GGCCATCGGCACCCGTTCTGGAGCCATCAAGCTCTACGGAGCCCCAGGCGTGGAGTTCATGGGGCTGCACCAGGAGAACAACGCTGTGAC
GCAGATCCACCTCCTGCCCGGCCAGTGCCAGCTGGTCACCCTGCTGGATGACAACAGCCTGCACCTTTGGAGCCTGAAGGTCAAGGGCGG
GGCATCGGAGCTGCAGGAGGATGAGAGCTTCACACTGCGTGGACCCCCAGGGGCTGCCCCCAGTGCCACACAGATCACCGTGGTCCTGCC
ACATTCCTCCTGCGAGCTGCTCTACCTGGGCACCGAGAGTGGCAACGTGTTTGTGGTGCAGCTGCCAGCTTTTCGTGCGCTGGAGGACCG
GACCATCAGCTCGGACGCGGTGCTGCAGCGGTTGCCAGAGGAGGCCCGCCACCGGCGTGTGTTCGAGATGGTGGAGGCACTGCAGGAGCA
CCCTCGAGACCCCAACCAGATCCTGATCGGCTACAGCCGAGGCCTCGTTGTCATCTGGGACCTACAGGGCAGCCGCGTGCTCTACCACTT
CCTCAGCAGCCAGCAACTGGAGAACATCTGGTGGCAGCGGGACGGCCGCCTGCTCGTCAGCTGTCACTCTGACGGCAGCTACTGCCAGTG
GCCCGTGTCCAGCGAAGCCCAGCAACCAGAGCCCCTCCGCAGCCTCGTGCCTTACGGTCCCTTTCCTTGCAAAGCGATTACCAGAATCCT
CTGGCTGACCACTAGGCAGGGGTTGCCCTTCACCATCTTCCAGGGTGGCATGCCACGGGCCAGCTACGGGGACCGCCACTGCATCTCAGT
GATCCACGATGGCCAGCAGACGGCCTTCGACTTCACCTCCCGTGTCATCGGCTTCACTGTCCTCACAGAGGCAGACCCTGCAGCCACCTT
TGACGACCCCTATGCCCTGGTGGTGCTGGCTGAGGAGGAGCTGGTGGTGATTGACCTGCAGACAGCAGGCTGGCCACCGGTCCAGCTGCC
CTACCTGGCTTCTCTGCACTGTTCCGCCATCACCTGCTCTCACCACGTCTCCAACATCCCGCTGAAGCTGTGGGAGCGGATCATTGCCGC
CGGCAGCCGGCAGAACGCACACTTCTCCACCATGGAGTGGCCAATTGATGGTGGCACCAGCCTGACCCCAGCCCCACCCCAGAGGGACCT
GCTGCTCACAGGAGAACTTCAGTGCCCAGGGCGAGGACGAGTGGCCCCCACTCCGCAAGGCCCTGATGGACAACCCCTCCCTGGCATTCG
TTCGTCCCCGATGGATCTACAGTTGCAATGAGAAGCAGAAGTTACTTCCTCACCAGCTCTATGGGGTGGTGCCGCAAGCCTGAAGTATGT
GCTATACACACACACACACACACACACACACACACACACACACGATGCATTTAATAAAGATGAGTTGGTTCTCATCCAAGAGTCTCCCAA
AACTCTAAGAGGCTCCCTGGGACCTGGGGAAGAATGCTGGGCACCTCCGTCAGAGATCTGGTAGAGAAGGAACTCTTTGTCTCTTCTGCT
TGGCCCCTTATCCCTGTGTTGGCAAGAGGCAGGGAACTGGGAATCTGACCCTCAGCACTGCCCCTCAACTTTTTCTGGCCCTCTGAGCCA
CACCTGTATCTTGGCTGTCCCTTTGTGGCTGGAGGCCTGGGTACCCATGAGGCTTGTCTCTCTCCTGAAGCCTCAGGAGCTCGAGGACAA
TATGAGTGACCGGGTTCAGTTTGTGATCACAGCACAGGAATGGGATCCCAGCTTTGAGGAGATTTCTTCCAGGGCAAGCACTTCTTTCTT
TACGGGGAGTTCCCTGGGGACGAGCGGCGGAAACTCATCCGATACGTCACAGCCTTCAATGGGGTGGCAGAGCAGAAGGAACACAGACTG
CCCCCTGGCCAGGAGGAGAATGGGGAAGACCCGTATGCAGGCTCCACGGATGAGAACACGGACAGTGAGGAACACCAGGAGCCTCCTGAT
CTGCCAGTCCCTGAGCTCCCAGAAGGACAGGACAATGGGGCGGAAGATTCTGGGGACACAGAGGATGAGCTGAGGAGCAACCCCAGACCA
AAACCAAGCCCACTCAGGCAGCTGGACCCAGCTCACCCCAGAAGCCCCCAACCCCTGAAGAGACCAAAGCAGCCTCACCAGTGCTCCAGG
AAGATATAGACATTGAGGGGGTACAGTCAGGTACCTCATGGCAGGGCCAGGTTCCAGCAGTGAGGAGGATGAGGCCTCTCACAGCGGTGG
CAGCGGAGATGAAGCCCCCAAGCTTCCTCAGAAGCTGTGCCTTTGCCAACACCCCCAAGTACAGCCAGGTCCTAGGCCTGGGAGGCCGCA
TCGTGCGTAAGGAGTGGGTGCTGGACTGTCACCGCATGCGTCGGCGGCTGCCCTCCCAGAGTGCCAGCTCCAACTCGTACCCCAGCCACA
GCCCCAGTCCCTGCCCGAGCACAGGGGGCAGTGACAGGCAAACCCCGAGGAGAAGGCACCGAGCCCAGACGACCCCGAGCTGGCCCAGAG
GAGCTGGGGAAGATCCTTCAGGGTGTGGTAGTGGTGCTGAGTGGCTTCCAGAACCCCTTCCGCTCCGAGCTGCGAGATAAGGCCCTAGAG
CTTGGGGCCAAGTATCGGCCAGACTGGACCCGGGACAGCACGCACCTCATCCCAAAGGGAAGAGGAAGTTGGATTTGAACCAAGAAGAAA

>45707_45707_1_LLGL2-XRCC1_LLGL2_chr17_73565165_ENST00000167462_XRCC1_chr19_44057048_ENST00000262887_length(amino acids)=476AA_BP=
MRRFLRPGHDPVRERLKRDLFQFNKTVEHGFPHQPSALGYSPSLRILAIGTRSGAIKLYGAPGVEFMGLHQENNAVTQIHLLPGQCQLVT
LLDDNSLHLWSLKVKGGASELQEDESFTLRGPPGAAPSATQITVVLPHSSCELLYLGTESGNVFVVQLPAFRALEDRTISSDAVLQRLPE
EARHRRVFEMVEALQEHPRDPNQILIGYSRGLVVIWDLQGSRVLYHFLSSQQLENIWWQRDGRLLVSCHSDGSYCQWPVSSEAQQPEPLR
SLVPYGPFPCKAITRILWLTTRQGLPFTIFQGGMPRASYGDRHCISVIHDGQQTAFDFTSRVIGFTVLTEADPAATFDDPYALVVLAEEE
LVVIDLQTAGWPPVQLPYLASLHCSAITCSHHVSNIPLKLWERIIAAGSRQNAHFSTMEWPIDGGTSLTPAPPQRDLLLTGELQCPGRGR

--------------------------------------------------------------
>45707_45707_2_LLGL2-XRCC1_LLGL2_chr17_73565165_ENST00000167462_XRCC1_chr19_44057048_ENST00000543982_length(transcript)=2758nt_BP=1499nt
CGCCCAGCAGCCCGTGGGCAGGCGCGGCGGAGCGAGCGGGGCCGGCGGCGGGCGCCGAGGGACGCCGAGGCCTCGGGCGGGGGCTGGCCC
GGGGTTCCAGGTCTCCAGTGGGGGCTGCAGACTAAGCAAAATGAGGCGGTTCCTGAGGCCAGGGCATGACCCTGTGCGGGAGAGGCTCAA
GCGGGACCTGTTCCAGTTTAACAAGACGGTGGAGCATGGCTTCCCGCACCAGCCCAGCGCCCTCGGCTACAGCCCGTCCCTGCGCATCCT
GGCCATCGGCACCCGTTCTGGAGCCATCAAGCTCTACGGAGCCCCAGGCGTGGAGTTCATGGGGCTGCACCAGGAGAACAACGCTGTGAC
GCAGATCCACCTCCTGCCCGGCCAGTGCCAGCTGGTCACCCTGCTGGATGACAACAGCCTGCACCTTTGGAGCCTGAAGGTCAAGGGCGG
GGCATCGGAGCTGCAGGAGGATGAGAGCTTCACACTGCGTGGACCCCCAGGGGCTGCCCCCAGTGCCACACAGATCACCGTGGTCCTGCC
ACATTCCTCCTGCGAGCTGCTCTACCTGGGCACCGAGAGTGGCAACGTGTTTGTGGTGCAGCTGCCAGCTTTTCGTGCGCTGGAGGACCG
GACCATCAGCTCGGACGCGGTGCTGCAGCGGTTGCCAGAGGAGGCCCGCCACCGGCGTGTGTTCGAGATGGTGGAGGCACTGCAGGAGCA
CCCTCGAGACCCCAACCAGATCCTGATCGGCTACAGCCGAGGCCTCGTTGTCATCTGGGACCTACAGGGCAGCCGCGTGCTCTACCACTT
CCTCAGCAGCCAGCAACTGGAGAACATCTGGTGGCAGCGGGACGGCCGCCTGCTCGTCAGCTGTCACTCTGACGGCAGCTACTGCCAGTG
GCCCGTGTCCAGCGAAGCCCAGCAACCAGAGCCCCTCCGCAGCCTCGTGCCTTACGGTCCCTTTCCTTGCAAAGCGATTACCAGAATCCT
CTGGCTGACCACTAGGCAGGGGTTGCCCTTCACCATCTTCCAGGGTGGCATGCCACGGGCCAGCTACGGGGACCGCCACTGCATCTCAGT
GATCCACGATGGCCAGCAGACGGCCTTCGACTTCACCTCCCGTGTCATCGGCTTCACTGTCCTCACAGAGGCAGACCCTGCAGCCACCTT
TGACGACCCCTATGCCCTGGTGGTGCTGGCTGAGGAGGAGCTGGTGGTGATTGACCTGCAGACAGCAGGCTGGCCACCGGTCCAGCTGCC
CTACCTGGCTTCTCTGCACTGTTCCGCCATCACCTGCTCTCACCACGTCTCCAACATCCCGCTGAAGCTGTGGGAGCGGATCATTGCCGC
CGGCAGCCGGCAGAACGCACACTTCTCCACCATGGAGTGGCCAATTGATGGTGGCACCAGCCTGACCCCAGCCCCACCCCAGAGGGACCT
GCTGCTCACAGGAGAACTTCAGTGCCCAGGGCGAGGACGAGTGGCCCCCACTCCGCAAGGCCCTGATGGACAACCCCTCCCTGGCATTCG
TTCGTCCCCGATGGATCTACAGTTGCAATGAGAAGCAGAAGTTACTTCCTCACCAGCTCTATGGGGTGGTGCCGCAAGCCTGAAGTATGT
GCTATACACACACACACACACACACACACACACACACACACACGATGCATTTAATAAAGATGAGTTGGTTCTCGGAGCTCGAGGACAATA
TGAGTGACCGGGTTCAGTTTGTGATCACAGCACAGGAATGGGATCCCAGCTTTGAGGAGATTTCTTCCAGGGCAAGCACTTCTTTCTTTA
CGGGGAGTTCCCTGGGGACGAGCGGCGGAAACTCATCCGATACGTCACAGCCTTCAATGGGGTGGCAGAGCAGAAGGAACACAGACTGCC
CCCTGGCCAGGAGGAGAATGGGGAAGACCCGTATGCAGGCTCCACGGATGAGAACACGGACAGTGAGGAACACCAGGAGCCTCCTGATCT
GCCAGTCCCTGAGCTCCCAGAAGGACAGGACAATGGGGCGGAAGATTCTGGGGACACAGAGGATGAGCTGAGGAGCAACCCCAGACCAAA
ACCAAGCCCACTCAGGCAGCTGGACCCAGCTCACCCCAGAAGCCCCCAACCCCTGAAGAGACCAAAGCAGCCTCACCAGTGCTCCAGGAA
GATATAGACATTGAGGGGGTACAGTCAGGTACCTCATGGCAGGGCCAGGTTCCAGCAGTGAGGAGGATGAGGCCTCTCACAGCGGTGGCA
GCGGAGATGAAGCCCCCAAGCTTCCTCAGAAGCTGTGCCTTTGCCAACACCCCCAAGTACAGCCAGGTCCTAGGCCTGGGAGGCCGCATC
GTGCGTAAGGAGTGGGTGCTGGACTGTCACCGCATGCGTCGGCGGCTGCCCTCCCAGAGTGCCAGCTCCAACTCGTACCCCAGCCACAGC
CCCAGTCCCTGCCCGAGCACAGGGGGCAGTGACAGGCAAACCCCGAGGAGAAGGCACCGAGCCCAGACGACCCCGAGCTGGCCCAGAGGA
GCTGGGGAAGATCCTTCAGGGTGTGGTAGTGGTGCTGAGTGGCTTCCAGAACCCCTTCCGCTCCGAGCTGCGAGATAAGGCCCTAGAGCT
TGGGGCCAAGTATCGGCCAGACTGGACCCGGGACAGCACGCACCTCATCCCAAAGGGAAGAGGAAGTTGGATTTGAACCAAGAAGAAAAG

>45707_45707_2_LLGL2-XRCC1_LLGL2_chr17_73565165_ENST00000167462_XRCC1_chr19_44057048_ENST00000543982_length(amino acids)=476AA_BP=
MRRFLRPGHDPVRERLKRDLFQFNKTVEHGFPHQPSALGYSPSLRILAIGTRSGAIKLYGAPGVEFMGLHQENNAVTQIHLLPGQCQLVT
LLDDNSLHLWSLKVKGGASELQEDESFTLRGPPGAAPSATQITVVLPHSSCELLYLGTESGNVFVVQLPAFRALEDRTISSDAVLQRLPE
EARHRRVFEMVEALQEHPRDPNQILIGYSRGLVVIWDLQGSRVLYHFLSSQQLENIWWQRDGRLLVSCHSDGSYCQWPVSSEAQQPEPLR
SLVPYGPFPCKAITRILWLTTRQGLPFTIFQGGMPRASYGDRHCISVIHDGQQTAFDFTSRVIGFTVLTEADPAATFDDPYALVVLAEEE
LVVIDLQTAGWPPVQLPYLASLHCSAITCSHHVSNIPLKLWERIIAAGSRQNAHFSTMEWPIDGGTSLTPAPPQRDLLLTGELQCPGRGR

--------------------------------------------------------------
>45707_45707_3_LLGL2-XRCC1_LLGL2_chr17_73565165_ENST00000392550_XRCC1_chr19_44057048_ENST00000262887_length(transcript)=3017nt_BP=1486nt
GTGGGCAGGCGCGGCGGAGCGAGCGGGGCCGGCGGCGGGCGCCGAGGGACGCCGAGGCCTCGGGCGGGGGCTGGCCCGGGGTTCCAGGTC
TCCAGTGGGGGCTGCAGACTAAGCAAAATGAGGCGGTTCCTGAGGCCAGGGCATGACCCTGTGCGGGAGAGGCTCAAGCGGGACCTGTTC
CAGTTTAACAAGACGGTGGAGCATGGCTTCCCGCACCAGCCCAGCGCCCTCGGCTACAGCCCGTCCCTGCGCATCCTGGCCATCGGCACC
CGTTCTGGAGCCATCAAGCTCTACGGAGCCCCAGGCGTGGAGTTCATGGGGCTGCACCAGGAGAACAACGCTGTGACGCAGATCCACCTC
CTGCCCGGCCAGTGCCAGCTGGTCACCCTGCTGGATGACAACAGCCTGCACCTTTGGAGCCTGAAGGTCAAGGGCGGGGCATCGGAGCTG
CAGGAGGATGAGAGCTTCACACTGCGTGGACCCCCAGGGGCTGCCCCCAGTGCCACACAGATCACCGTGGTCCTGCCACATTCCTCCTGC
GAGCTGCTCTACCTGGGCACCGAGAGTGGCAACGTGTTTGTGGTGCAGCTGCCAGCTTTTCGTGCGCTGGAGGACCGGACCATCAGCTCG
GACGCGGTGCTGCAGCGGTTGCCAGAGGAGGCCCGCCACCGGCGTGTGTTCGAGATGGTGGAGGCACTGCAGGAGCACCCTCGAGACCCC
AACCAGATCCTGATCGGCTACAGCCGAGGCCTCGTTGTCATCTGGGACCTACAGGGCAGCCGCGTGCTCTACCACTTCCTCAGCAGCCAG
CAACTGGAGAACATCTGGTGGCAGCGGGACGGCCGCCTGCTCGTCAGCTGTCACTCTGACGGCAGCTACTGCCAGTGGCCCGTGTCCAGC
GAAGCCCAGCAACCAGAGCCCCTCCGCAGCCTCGTGCCTTACGGTCCCTTTCCTTGCAAAGCGATTACCAGAATCCTCTGGCTGACCACT
AGGCAGGGGTTGCCCTTCACCATCTTCCAGGGTGGCATGCCACGGGCCAGCTACGGGGACCGCCACTGCATCTCAGTGATCCACGATGGC
CAGCAGACGGCCTTCGACTTCACCTCCCGTGTCATCGGCTTCACTGTCCTCACAGAGGCAGACCCTGCAGCCACCTTTGACGACCCCTAT
GCCCTGGTGGTGCTGGCTGAGGAGGAGCTGGTGGTGATTGACCTGCAGACAGCAGGCTGGCCACCGGTCCAGCTGCCCTACCTGGCTTCT
CTGCACTGTTCCGCCATCACCTGCTCTCACCACGTCTCCAACATCCCGCTGAAGCTGTGGGAGCGGATCATTGCCGCCGGCAGCCGGCAG
AACGCACACTTCTCCACCATGGAGTGGCCAATTGATGGTGGCACCAGCCTGACCCCAGCCCCACCCCAGAGGGACCTGCTGCTCACAGGA
GAACTTCAGTGCCCAGGGCGAGGACGAGTGGCCCCCACTCCGCAAGGCCCTGATGGACAACCCCTCCCTGGCATTCGTTCGTCCCCGATG
GATCTACAGTTGCAATGAGAAGCAGAAGTTACTTCCTCACCAGCTCTATGGGGTGGTGCCGCAAGCCTGAAGTATGTGCTATACACACAC
ACACACACACACACACACACACACACACACGATGCATTTAATAAAGATGAGTTGGTTCTCATCCAAGAGTCTCCCAAAACTCTAAGAGGC
TCCCTGGGACCTGGGGAAGAATGCTGGGCACCTCCGTCAGAGATCTGGTAGAGAAGGAACTCTTTGTCTCTTCTGCTTGGCCCCTTATCC
CTGTGTTGGCAAGAGGCAGGGAACTGGGAATCTGACCCTCAGCACTGCCCCTCAACTTTTTCTGGCCCTCTGAGCCACACCTGTATCTTG
GCTGTCCCTTTGTGGCTGGAGGCCTGGGTACCCATGAGGCTTGTCTCTCTCCTGAAGCCTCAGGAGCTCGAGGACAATATGAGTGACCGG
GTTCAGTTTGTGATCACAGCACAGGAATGGGATCCCAGCTTTGAGGAGATTTCTTCCAGGGCAAGCACTTCTTTCTTTACGGGGAGTTCC
CTGGGGACGAGCGGCGGAAACTCATCCGATACGTCACAGCCTTCAATGGGGTGGCAGAGCAGAAGGAACACAGACTGCCCCCTGGCCAGG
AGGAGAATGGGGAAGACCCGTATGCAGGCTCCACGGATGAGAACACGGACAGTGAGGAACACCAGGAGCCTCCTGATCTGCCAGTCCCTG
AGCTCCCAGAAGGACAGGACAATGGGGCGGAAGATTCTGGGGACACAGAGGATGAGCTGAGGAGCAACCCCAGACCAAAACCAAGCCCAC
TCAGGCAGCTGGACCCAGCTCACCCCAGAAGCCCCCAACCCCTGAAGAGACCAAAGCAGCCTCACCAGTGCTCCAGGAAGATATAGACAT
TGAGGGGGTACAGTCAGGTACCTCATGGCAGGGCCAGGTTCCAGCAGTGAGGAGGATGAGGCCTCTCACAGCGGTGGCAGCGGAGATGAA
GCCCCCAAGCTTCCTCAGAAGCTGTGCCTTTGCCAACACCCCCAAGTACAGCCAGGTCCTAGGCCTGGGAGGCCGCATCGTGCGTAAGGA
GTGGGTGCTGGACTGTCACCGCATGCGTCGGCGGCTGCCCTCCCAGAGTGCCAGCTCCAACTCGTACCCCAGCCACAGCCCCAGTCCCTG
CCCGAGCACAGGGGGCAGTGACAGGCAAACCCCGAGGAGAAGGCACCGAGCCCAGACGACCCCGAGCTGGCCCAGAGGAGCTGGGGAAGA
TCCTTCAGGGTGTGGTAGTGGTGCTGAGTGGCTTCCAGAACCCCTTCCGCTCCGAGCTGCGAGATAAGGCCCTAGAGCTTGGGGCCAAGT
ATCGGCCAGACTGGACCCGGGACAGCACGCACCTCATCCCAAAGGGAAGAGGAAGTTGGATTTGAACCAAGAAGAAAAGAAGACCCCCAG

>45707_45707_3_LLGL2-XRCC1_LLGL2_chr17_73565165_ENST00000392550_XRCC1_chr19_44057048_ENST00000262887_length(amino acids)=476AA_BP=
MRRFLRPGHDPVRERLKRDLFQFNKTVEHGFPHQPSALGYSPSLRILAIGTRSGAIKLYGAPGVEFMGLHQENNAVTQIHLLPGQCQLVT
LLDDNSLHLWSLKVKGGASELQEDESFTLRGPPGAAPSATQITVVLPHSSCELLYLGTESGNVFVVQLPAFRALEDRTISSDAVLQRLPE
EARHRRVFEMVEALQEHPRDPNQILIGYSRGLVVIWDLQGSRVLYHFLSSQQLENIWWQRDGRLLVSCHSDGSYCQWPVSSEAQQPEPLR
SLVPYGPFPCKAITRILWLTTRQGLPFTIFQGGMPRASYGDRHCISVIHDGQQTAFDFTSRVIGFTVLTEADPAATFDDPYALVVLAEEE
LVVIDLQTAGWPPVQLPYLASLHCSAITCSHHVSNIPLKLWERIIAAGSRQNAHFSTMEWPIDGGTSLTPAPPQRDLLLTGELQCPGRGR

--------------------------------------------------------------
>45707_45707_4_LLGL2-XRCC1_LLGL2_chr17_73565165_ENST00000392550_XRCC1_chr19_44057048_ENST00000543982_length(transcript)=2745nt_BP=1486nt
GTGGGCAGGCGCGGCGGAGCGAGCGGGGCCGGCGGCGGGCGCCGAGGGACGCCGAGGCCTCGGGCGGGGGCTGGCCCGGGGTTCCAGGTC
TCCAGTGGGGGCTGCAGACTAAGCAAAATGAGGCGGTTCCTGAGGCCAGGGCATGACCCTGTGCGGGAGAGGCTCAAGCGGGACCTGTTC
CAGTTTAACAAGACGGTGGAGCATGGCTTCCCGCACCAGCCCAGCGCCCTCGGCTACAGCCCGTCCCTGCGCATCCTGGCCATCGGCACC
CGTTCTGGAGCCATCAAGCTCTACGGAGCCCCAGGCGTGGAGTTCATGGGGCTGCACCAGGAGAACAACGCTGTGACGCAGATCCACCTC
CTGCCCGGCCAGTGCCAGCTGGTCACCCTGCTGGATGACAACAGCCTGCACCTTTGGAGCCTGAAGGTCAAGGGCGGGGCATCGGAGCTG
CAGGAGGATGAGAGCTTCACACTGCGTGGACCCCCAGGGGCTGCCCCCAGTGCCACACAGATCACCGTGGTCCTGCCACATTCCTCCTGC
GAGCTGCTCTACCTGGGCACCGAGAGTGGCAACGTGTTTGTGGTGCAGCTGCCAGCTTTTCGTGCGCTGGAGGACCGGACCATCAGCTCG
GACGCGGTGCTGCAGCGGTTGCCAGAGGAGGCCCGCCACCGGCGTGTGTTCGAGATGGTGGAGGCACTGCAGGAGCACCCTCGAGACCCC
AACCAGATCCTGATCGGCTACAGCCGAGGCCTCGTTGTCATCTGGGACCTACAGGGCAGCCGCGTGCTCTACCACTTCCTCAGCAGCCAG
CAACTGGAGAACATCTGGTGGCAGCGGGACGGCCGCCTGCTCGTCAGCTGTCACTCTGACGGCAGCTACTGCCAGTGGCCCGTGTCCAGC
GAAGCCCAGCAACCAGAGCCCCTCCGCAGCCTCGTGCCTTACGGTCCCTTTCCTTGCAAAGCGATTACCAGAATCCTCTGGCTGACCACT
AGGCAGGGGTTGCCCTTCACCATCTTCCAGGGTGGCATGCCACGGGCCAGCTACGGGGACCGCCACTGCATCTCAGTGATCCACGATGGC
CAGCAGACGGCCTTCGACTTCACCTCCCGTGTCATCGGCTTCACTGTCCTCACAGAGGCAGACCCTGCAGCCACCTTTGACGACCCCTAT
GCCCTGGTGGTGCTGGCTGAGGAGGAGCTGGTGGTGATTGACCTGCAGACAGCAGGCTGGCCACCGGTCCAGCTGCCCTACCTGGCTTCT
CTGCACTGTTCCGCCATCACCTGCTCTCACCACGTCTCCAACATCCCGCTGAAGCTGTGGGAGCGGATCATTGCCGCCGGCAGCCGGCAG
AACGCACACTTCTCCACCATGGAGTGGCCAATTGATGGTGGCACCAGCCTGACCCCAGCCCCACCCCAGAGGGACCTGCTGCTCACAGGA
GAACTTCAGTGCCCAGGGCGAGGACGAGTGGCCCCCACTCCGCAAGGCCCTGATGGACAACCCCTCCCTGGCATTCGTTCGTCCCCGATG
GATCTACAGTTGCAATGAGAAGCAGAAGTTACTTCCTCACCAGCTCTATGGGGTGGTGCCGCAAGCCTGAAGTATGTGCTATACACACAC
ACACACACACACACACACACACACACACACGATGCATTTAATAAAGATGAGTTGGTTCTCGGAGCTCGAGGACAATATGAGTGACCGGGT
TCAGTTTGTGATCACAGCACAGGAATGGGATCCCAGCTTTGAGGAGATTTCTTCCAGGGCAAGCACTTCTTTCTTTACGGGGAGTTCCCT
GGGGACGAGCGGCGGAAACTCATCCGATACGTCACAGCCTTCAATGGGGTGGCAGAGCAGAAGGAACACAGACTGCCCCCTGGCCAGGAG
GAGAATGGGGAAGACCCGTATGCAGGCTCCACGGATGAGAACACGGACAGTGAGGAACACCAGGAGCCTCCTGATCTGCCAGTCCCTGAG
CTCCCAGAAGGACAGGACAATGGGGCGGAAGATTCTGGGGACACAGAGGATGAGCTGAGGAGCAACCCCAGACCAAAACCAAGCCCACTC
AGGCAGCTGGACCCAGCTCACCCCAGAAGCCCCCAACCCCTGAAGAGACCAAAGCAGCCTCACCAGTGCTCCAGGAAGATATAGACATTG
AGGGGGTACAGTCAGGTACCTCATGGCAGGGCCAGGTTCCAGCAGTGAGGAGGATGAGGCCTCTCACAGCGGTGGCAGCGGAGATGAAGC
CCCCAAGCTTCCTCAGAAGCTGTGCCTTTGCCAACACCCCCAAGTACAGCCAGGTCCTAGGCCTGGGAGGCCGCATCGTGCGTAAGGAGT
GGGTGCTGGACTGTCACCGCATGCGTCGGCGGCTGCCCTCCCAGAGTGCCAGCTCCAACTCGTACCCCAGCCACAGCCCCAGTCCCTGCC
CGAGCACAGGGGGCAGTGACAGGCAAACCCCGAGGAGAAGGCACCGAGCCCAGACGACCCCGAGCTGGCCCAGAGGAGCTGGGGAAGATC
CTTCAGGGTGTGGTAGTGGTGCTGAGTGGCTTCCAGAACCCCTTCCGCTCCGAGCTGCGAGATAAGGCCCTAGAGCTTGGGGCCAAGTAT
CGGCCAGACTGGACCCGGGACAGCACGCACCTCATCCCAAAGGGAAGAGGAAGTTGGATTTGAACCAAGAAGAAAAGAAGACCCCCAGCA

>45707_45707_4_LLGL2-XRCC1_LLGL2_chr17_73565165_ENST00000392550_XRCC1_chr19_44057048_ENST00000543982_length(amino acids)=476AA_BP=
MRRFLRPGHDPVRERLKRDLFQFNKTVEHGFPHQPSALGYSPSLRILAIGTRSGAIKLYGAPGVEFMGLHQENNAVTQIHLLPGQCQLVT
LLDDNSLHLWSLKVKGGASELQEDESFTLRGPPGAAPSATQITVVLPHSSCELLYLGTESGNVFVVQLPAFRALEDRTISSDAVLQRLPE
EARHRRVFEMVEALQEHPRDPNQILIGYSRGLVVIWDLQGSRVLYHFLSSQQLENIWWQRDGRLLVSCHSDGSYCQWPVSSEAQQPEPLR
SLVPYGPFPCKAITRILWLTTRQGLPFTIFQGGMPRASYGDRHCISVIHDGQQTAFDFTSRVIGFTVLTEADPAATFDDPYALVVLAEEE
LVVIDLQTAGWPPVQLPYLASLHCSAITCSHHVSNIPLKLWERIIAAGSRQNAHFSTMEWPIDGGTSLTPAPPQRDLLLTGELQCPGRGR

--------------------------------------------------------------
>45707_45707_5_LLGL2-XRCC1_LLGL2_chr17_73565165_ENST00000577200_XRCC1_chr19_44057048_ENST00000262887_length(transcript)=3004nt_BP=1473nt
GGCTCACTGCAACCTCTGCCTCCCGGGTTCAAGCAATTCTCCTGCCTCGGCCTCCTGAGTAGCTGGGATTACAGGTCTCCAGTGGGGGCT
GCAGACTAAGCAAAATGAGGCGGTTCCTGAGGCCAGGGCATGACCCTGTGCGGGAGAGGCTCAAGCGGGACCTGTTCCAGTTTAACAAGA
CGGTGGAGCATGGCTTCCCGCACCAGCCCAGCGCCCTCGGCTACAGCCCGTCCCTGCGCATCCTGGCCATCGGCACCCGTTCTGGAGCCA
TCAAGCTCTACGGAGCCCCAGGCGTGGAGTTCATGGGGCTGCACCAGGAGAACAACGCTGTGACGCAGATCCACCTCCTGCCCGGCCAGT
GCCAGCTGGTCACCCTGCTGGATGACAACAGCCTGCACCTTTGGAGCCTGAAGGTCAAGGGCGGGGCATCGGAGCTGCAGGAGGATGAGA
GCTTCACACTGCGTGGACCCCCAGGGGCTGCCCCCAGTGCCACACAGATCACCGTGGTCCTGCCACATTCCTCCTGCGAGCTGCTCTACC
TGGGCACCGAGAGTGGCAACGTGTTTGTGGTGCAGCTGCCAGCTTTTCGTGCGCTGGAGGACCGGACCATCAGCTCGGACGCGGTGCTGC
AGCGGTTGCCAGAGGAGGCCCGCCACCGGCGTGTGTTCGAGATGGTGGAGGCACTGCAGGAGCACCCTCGAGACCCCAACCAGATCCTGA
TCGGCTACAGCCGAGGCCTCGTTGTCATCTGGGACCTACAGGGCAGCCGCGTGCTCTACCACTTCCTCAGCAGCCAGCAACTGGAGAACA
TCTGGTGGCAGCGGGACGGCCGCCTGCTCGTCAGCTGTCACTCTGACGGCAGCTACTGCCAGTGGCCCGTGTCCAGCGAAGCCCAGCAAC
CAGAGCCCCTCCGCAGCCTCGTGCCTTACGGTCCCTTTCCTTGCAAAGCGATTACCAGAATCCTCTGGCTGACCACTAGGCAGGGGTTGC
CCTTCACCATCTTCCAGGGTGGCATGCCACGGGCCAGCTACGGGGACCGCCACTGCATCTCAGTGATCCACGATGGCCAGCAGACGGCCT
TCGACTTCACCTCCCGTGTCATCGGCTTCACTGTCCTCACAGAGGCAGACCCTGCAGCCACCTTTGACGACCCCTATGCCCTGGTGGTGC
TGGCTGAGGAGGAGCTGGTGGTGATTGACCTGCAGACAGCAGGCTGGCCACCGGTCCAGCTGCCCTACCTGGCTTCTCTGCACTGTTCCG
CCATCACCTGCTCTCACCACGTCTCCAACATCCCGCTGAAGCTGTGGGAGCGGATCATTGCCGCCGGCAGCCGGCAGAACGCACACTTCT
CCACCATGGAGTGGCCAATTGATGGTGGCACCAGCCTGACCCCAGCCCCACCCCAGAGGGACCTGCTGCTCACAGGAGAACTTCAGTGCC
CAGGGCGAGGACGAGTGGCCCCCACTCCGCAAGGCCCTGATGGACAACCCCTCCCTGGCATTCGTTCGTCCCCGATGGATCTACAGTTGC
AATGAGAAGCAGAAGTTACTTCCTCACCAGCTCTATGGGGTGGTGCCGCAAGCCTGAAGTATGTGCTATACACACACACACACACACACA
CACACACACACACACACGATGCATTTAATAAAGATGAGTTGGTTCTCATCCAAGAGTCTCCCAAAACTCTAAGAGGCTCCCTGGGACCTG
GGGAAGAATGCTGGGCACCTCCGTCAGAGATCTGGTAGAGAAGGAACTCTTTGTCTCTTCTGCTTGGCCCCTTATCCCTGTGTTGGCAAG
AGGCAGGGAACTGGGAATCTGACCCTCAGCACTGCCCCTCAACTTTTTCTGGCCCTCTGAGCCACACCTGTATCTTGGCTGTCCCTTTGT
GGCTGGAGGCCTGGGTACCCATGAGGCTTGTCTCTCTCCTGAAGCCTCAGGAGCTCGAGGACAATATGAGTGACCGGGTTCAGTTTGTGA
TCACAGCACAGGAATGGGATCCCAGCTTTGAGGAGATTTCTTCCAGGGCAAGCACTTCTTTCTTTACGGGGAGTTCCCTGGGGACGAGCG
GCGGAAACTCATCCGATACGTCACAGCCTTCAATGGGGTGGCAGAGCAGAAGGAACACAGACTGCCCCCTGGCCAGGAGGAGAATGGGGA
AGACCCGTATGCAGGCTCCACGGATGAGAACACGGACAGTGAGGAACACCAGGAGCCTCCTGATCTGCCAGTCCCTGAGCTCCCAGAAGG
ACAGGACAATGGGGCGGAAGATTCTGGGGACACAGAGGATGAGCTGAGGAGCAACCCCAGACCAAAACCAAGCCCACTCAGGCAGCTGGA
CCCAGCTCACCCCAGAAGCCCCCAACCCCTGAAGAGACCAAAGCAGCCTCACCAGTGCTCCAGGAAGATATAGACATTGAGGGGGTACAG
TCAGGTACCTCATGGCAGGGCCAGGTTCCAGCAGTGAGGAGGATGAGGCCTCTCACAGCGGTGGCAGCGGAGATGAAGCCCCCAAGCTTC
CTCAGAAGCTGTGCCTTTGCCAACACCCCCAAGTACAGCCAGGTCCTAGGCCTGGGAGGCCGCATCGTGCGTAAGGAGTGGGTGCTGGAC
TGTCACCGCATGCGTCGGCGGCTGCCCTCCCAGAGTGCCAGCTCCAACTCGTACCCCAGCCACAGCCCCAGTCCCTGCCCGAGCACAGGG
GGCAGTGACAGGCAAACCCCGAGGAGAAGGCACCGAGCCCAGACGACCCCGAGCTGGCCCAGAGGAGCTGGGGAAGATCCTTCAGGGTGT
GGTAGTGGTGCTGAGTGGCTTCCAGAACCCCTTCCGCTCCGAGCTGCGAGATAAGGCCCTAGAGCTTGGGGCCAAGTATCGGCCAGACTG
GACCCGGGACAGCACGCACCTCATCCCAAAGGGAAGAGGAAGTTGGATTTGAACCAAGAAGAAAAGAAGACCCCCAGCAAACCACCAGCC

>45707_45707_5_LLGL2-XRCC1_LLGL2_chr17_73565165_ENST00000577200_XRCC1_chr19_44057048_ENST00000262887_length(amino acids)=490AA_BP=
MGLQVSSGGCRLSKMRRFLRPGHDPVRERLKRDLFQFNKTVEHGFPHQPSALGYSPSLRILAIGTRSGAIKLYGAPGVEFMGLHQENNAV
TQIHLLPGQCQLVTLLDDNSLHLWSLKVKGGASELQEDESFTLRGPPGAAPSATQITVVLPHSSCELLYLGTESGNVFVVQLPAFRALED
RTISSDAVLQRLPEEARHRRVFEMVEALQEHPRDPNQILIGYSRGLVVIWDLQGSRVLYHFLSSQQLENIWWQRDGRLLVSCHSDGSYCQ
WPVSSEAQQPEPLRSLVPYGPFPCKAITRILWLTTRQGLPFTIFQGGMPRASYGDRHCISVIHDGQQTAFDFTSRVIGFTVLTEADPAAT
FDDPYALVVLAEEELVVIDLQTAGWPPVQLPYLASLHCSAITCSHHVSNIPLKLWERIIAAGSRQNAHFSTMEWPIDGGTSLTPAPPQRD

--------------------------------------------------------------
>45707_45707_6_LLGL2-XRCC1_LLGL2_chr17_73565165_ENST00000577200_XRCC1_chr19_44057048_ENST00000543982_length(transcript)=2732nt_BP=1473nt
GGCTCACTGCAACCTCTGCCTCCCGGGTTCAAGCAATTCTCCTGCCTCGGCCTCCTGAGTAGCTGGGATTACAGGTCTCCAGTGGGGGCT
GCAGACTAAGCAAAATGAGGCGGTTCCTGAGGCCAGGGCATGACCCTGTGCGGGAGAGGCTCAAGCGGGACCTGTTCCAGTTTAACAAGA
CGGTGGAGCATGGCTTCCCGCACCAGCCCAGCGCCCTCGGCTACAGCCCGTCCCTGCGCATCCTGGCCATCGGCACCCGTTCTGGAGCCA
TCAAGCTCTACGGAGCCCCAGGCGTGGAGTTCATGGGGCTGCACCAGGAGAACAACGCTGTGACGCAGATCCACCTCCTGCCCGGCCAGT
GCCAGCTGGTCACCCTGCTGGATGACAACAGCCTGCACCTTTGGAGCCTGAAGGTCAAGGGCGGGGCATCGGAGCTGCAGGAGGATGAGA
GCTTCACACTGCGTGGACCCCCAGGGGCTGCCCCCAGTGCCACACAGATCACCGTGGTCCTGCCACATTCCTCCTGCGAGCTGCTCTACC
TGGGCACCGAGAGTGGCAACGTGTTTGTGGTGCAGCTGCCAGCTTTTCGTGCGCTGGAGGACCGGACCATCAGCTCGGACGCGGTGCTGC
AGCGGTTGCCAGAGGAGGCCCGCCACCGGCGTGTGTTCGAGATGGTGGAGGCACTGCAGGAGCACCCTCGAGACCCCAACCAGATCCTGA
TCGGCTACAGCCGAGGCCTCGTTGTCATCTGGGACCTACAGGGCAGCCGCGTGCTCTACCACTTCCTCAGCAGCCAGCAACTGGAGAACA
TCTGGTGGCAGCGGGACGGCCGCCTGCTCGTCAGCTGTCACTCTGACGGCAGCTACTGCCAGTGGCCCGTGTCCAGCGAAGCCCAGCAAC
CAGAGCCCCTCCGCAGCCTCGTGCCTTACGGTCCCTTTCCTTGCAAAGCGATTACCAGAATCCTCTGGCTGACCACTAGGCAGGGGTTGC
CCTTCACCATCTTCCAGGGTGGCATGCCACGGGCCAGCTACGGGGACCGCCACTGCATCTCAGTGATCCACGATGGCCAGCAGACGGCCT
TCGACTTCACCTCCCGTGTCATCGGCTTCACTGTCCTCACAGAGGCAGACCCTGCAGCCACCTTTGACGACCCCTATGCCCTGGTGGTGC
TGGCTGAGGAGGAGCTGGTGGTGATTGACCTGCAGACAGCAGGCTGGCCACCGGTCCAGCTGCCCTACCTGGCTTCTCTGCACTGTTCCG
CCATCACCTGCTCTCACCACGTCTCCAACATCCCGCTGAAGCTGTGGGAGCGGATCATTGCCGCCGGCAGCCGGCAGAACGCACACTTCT
CCACCATGGAGTGGCCAATTGATGGTGGCACCAGCCTGACCCCAGCCCCACCCCAGAGGGACCTGCTGCTCACAGGAGAACTTCAGTGCC
CAGGGCGAGGACGAGTGGCCCCCACTCCGCAAGGCCCTGATGGACAACCCCTCCCTGGCATTCGTTCGTCCCCGATGGATCTACAGTTGC
AATGAGAAGCAGAAGTTACTTCCTCACCAGCTCTATGGGGTGGTGCCGCAAGCCTGAAGTATGTGCTATACACACACACACACACACACA
CACACACACACACACACGATGCATTTAATAAAGATGAGTTGGTTCTCGGAGCTCGAGGACAATATGAGTGACCGGGTTCAGTTTGTGATC
ACAGCACAGGAATGGGATCCCAGCTTTGAGGAGATTTCTTCCAGGGCAAGCACTTCTTTCTTTACGGGGAGTTCCCTGGGGACGAGCGGC
GGAAACTCATCCGATACGTCACAGCCTTCAATGGGGTGGCAGAGCAGAAGGAACACAGACTGCCCCCTGGCCAGGAGGAGAATGGGGAAG
ACCCGTATGCAGGCTCCACGGATGAGAACACGGACAGTGAGGAACACCAGGAGCCTCCTGATCTGCCAGTCCCTGAGCTCCCAGAAGGAC
AGGACAATGGGGCGGAAGATTCTGGGGACACAGAGGATGAGCTGAGGAGCAACCCCAGACCAAAACCAAGCCCACTCAGGCAGCTGGACC
CAGCTCACCCCAGAAGCCCCCAACCCCTGAAGAGACCAAAGCAGCCTCACCAGTGCTCCAGGAAGATATAGACATTGAGGGGGTACAGTC
AGGTACCTCATGGCAGGGCCAGGTTCCAGCAGTGAGGAGGATGAGGCCTCTCACAGCGGTGGCAGCGGAGATGAAGCCCCCAAGCTTCCT
CAGAAGCTGTGCCTTTGCCAACACCCCCAAGTACAGCCAGGTCCTAGGCCTGGGAGGCCGCATCGTGCGTAAGGAGTGGGTGCTGGACTG
TCACCGCATGCGTCGGCGGCTGCCCTCCCAGAGTGCCAGCTCCAACTCGTACCCCAGCCACAGCCCCAGTCCCTGCCCGAGCACAGGGGG
CAGTGACAGGCAAACCCCGAGGAGAAGGCACCGAGCCCAGACGACCCCGAGCTGGCCCAGAGGAGCTGGGGAAGATCCTTCAGGGTGTGG
TAGTGGTGCTGAGTGGCTTCCAGAACCCCTTCCGCTCCGAGCTGCGAGATAAGGCCCTAGAGCTTGGGGCCAAGTATCGGCCAGACTGGA
CCCGGGACAGCACGCACCTCATCCCAAAGGGAAGAGGAAGTTGGATTTGAACCAAGAAGAAAAGAAGACCCCCAGCAAACCACCAGCCCA

>45707_45707_6_LLGL2-XRCC1_LLGL2_chr17_73565165_ENST00000577200_XRCC1_chr19_44057048_ENST00000543982_length(amino acids)=490AA_BP=
MGLQVSSGGCRLSKMRRFLRPGHDPVRERLKRDLFQFNKTVEHGFPHQPSALGYSPSLRILAIGTRSGAIKLYGAPGVEFMGLHQENNAV
TQIHLLPGQCQLVTLLDDNSLHLWSLKVKGGASELQEDESFTLRGPPGAAPSATQITVVLPHSSCELLYLGTESGNVFVVQLPAFRALED
RTISSDAVLQRLPEEARHRRVFEMVEALQEHPRDPNQILIGYSRGLVVIWDLQGSRVLYHFLSSQQLENIWWQRDGRLLVSCHSDGSYCQ
WPVSSEAQQPEPLRSLVPYGPFPCKAITRILWLTTRQGLPFTIFQGGMPRASYGDRHCISVIHDGQQTAFDFTSRVIGFTVLTEADPAAT
FDDPYALVVLAEEELVVIDLQTAGWPPVQLPYLASLHCSAITCSHHVSNIPLKLWERIIAAGSRQNAHFSTMEWPIDGGTSLTPAPPQRD

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Fusion Gene PPI Analysis for LLGL2-XRCC1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for LLGL2-XRCC1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for LLGL2-XRCC1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource