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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:LLPH-ADK (FusionGDB2 ID:45708)

Fusion Gene Summary for LLPH-ADK

check button Fusion gene summary
Fusion gene informationFusion gene name: LLPH-ADK
Fusion gene ID: 45708
HgeneTgene
Gene symbol

LLPH

ADK

Gene ID

84298

132

Gene nameLLP homolog, long-term synaptic facilitation factoradenosine kinase
SynonymsC12orf31|hLLPAK
Cytomap

12q14.3

10q22.2|10q11-q24

Type of geneprotein-codingprotein-coding
Descriptionprotein LLP homologLLP homolog, long-term synaptic facilitation (Aplysia)human LAPS18-like proteinadenosine kinaseadenosine 5'-phosphotransferasetesticular tissue protein Li 14
Modification date2020031320200313
UniProtAcc

Q9BRT6

P55263

Ensembl transtripts involved in fusion geneENST00000266604, ENST00000446587, 
ENST00000467840, ENST00000286621, 
ENST00000372734, ENST00000539909, 
ENST00000541550, 
Fusion gene scores* DoF score2 X 3 X 2=1230 X 17 X 14=7140
# samples 364
** MAII scorelog2(3/12*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(64/7140*10)=-3.4797802640291
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: LLPH [Title/Abstract] AND ADK [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointLLPH(66524485)-ADK(76349040), # samples:1
LLPH(66522675)-ADK(76349039), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across LLPH (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ADK (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-E2-A10C-01ALLPHchr12

66524485

-ADKchr10

76349040

+
ChimerDB4BRCATCGA-E2-A10CLLPHchr12

66522675

-ADKchr10

76349039

+


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Fusion Gene ORF analysis for LLPH-ADK

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000266604ENST00000467840LLPHchr12

66522675

-ADKchr10

76349039

+
5CDS-intronENST00000446587ENST00000467840LLPHchr12

66522675

-ADKchr10

76349039

+
5UTR-3CDSENST00000266604ENST00000286621LLPHchr12

66524485

-ADKchr10

76349040

+
5UTR-3CDSENST00000266604ENST00000372734LLPHchr12

66524485

-ADKchr10

76349040

+
5UTR-3CDSENST00000266604ENST00000539909LLPHchr12

66524485

-ADKchr10

76349040

+
5UTR-3CDSENST00000266604ENST00000541550LLPHchr12

66524485

-ADKchr10

76349040

+
5UTR-intronENST00000266604ENST00000467840LLPHchr12

66524485

-ADKchr10

76349040

+
In-frameENST00000266604ENST00000286621LLPHchr12

66522675

-ADKchr10

76349039

+
In-frameENST00000266604ENST00000372734LLPHchr12

66522675

-ADKchr10

76349039

+
In-frameENST00000266604ENST00000539909LLPHchr12

66522675

-ADKchr10

76349039

+
In-frameENST00000266604ENST00000541550LLPHchr12

66522675

-ADKchr10

76349039

+
In-frameENST00000446587ENST00000286621LLPHchr12

66522675

-ADKchr10

76349039

+
In-frameENST00000446587ENST00000372734LLPHchr12

66522675

-ADKchr10

76349039

+
In-frameENST00000446587ENST00000539909LLPHchr12

66522675

-ADKchr10

76349039

+
In-frameENST00000446587ENST00000541550LLPHchr12

66522675

-ADKchr10

76349039

+
intron-3CDSENST00000446587ENST00000286621LLPHchr12

66524485

-ADKchr10

76349040

+
intron-3CDSENST00000446587ENST00000372734LLPHchr12

66524485

-ADKchr10

76349040

+
intron-3CDSENST00000446587ENST00000539909LLPHchr12

66524485

-ADKchr10

76349040

+
intron-3CDSENST00000446587ENST00000541550LLPHchr12

66524485

-ADKchr10

76349040

+
intron-intronENST00000446587ENST00000467840LLPHchr12

66524485

-ADKchr10

76349040

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000266604LLPHchr1266522675-ENST00000539909ADKchr1076349039+899282273644123
ENST00000266604LLPHchr1266522675-ENST00000286621ADKchr1076349039+675282273644123
ENST00000266604LLPHchr1266522675-ENST00000372734ADKchr1076349039+1503282273644123
ENST00000266604LLPHchr1266522675-ENST00000541550ADKchr1076349039+738282273644123
ENST00000446587LLPHchr1266522675-ENST00000539909ADKchr1076349039+1082465456827123
ENST00000446587LLPHchr1266522675-ENST00000286621ADKchr1076349039+858465456827123
ENST00000446587LLPHchr1266522675-ENST00000372734ADKchr1076349039+1686465456827123
ENST00000446587LLPHchr1266522675-ENST00000541550ADKchr1076349039+921465456827123

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000266604ENST00000539909LLPHchr1266522675-ADKchr1076349039+0.0202816460.9797183
ENST00000266604ENST00000286621LLPHchr1266522675-ADKchr1076349039+0.0336586130.96634144
ENST00000266604ENST00000372734LLPHchr1266522675-ADKchr1076349039+0.0219509770.978049
ENST00000266604ENST00000541550LLPHchr1266522675-ADKchr1076349039+0.031412130.9685878
ENST00000446587ENST00000539909LLPHchr1266522675-ADKchr1076349039+0.0477444340.9522556
ENST00000446587ENST00000286621LLPHchr1266522675-ADKchr1076349039+0.0521826150.9478173
ENST00000446587ENST00000372734LLPHchr1266522675-ADKchr1076349039+0.0452473650.95475256
ENST00000446587ENST00000541550LLPHchr1266522675-ADKchr1076349039+0.0603269450.93967307

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Fusion Genomic Features for LLPH-ADK


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
LLPHchr1266524484-ADKchr1076349039+3.74E-050.99996257
LLPHchr1266522675-ADKchr1076349039+2.56E-050.99997437
LLPHchr1266524484-ADKchr1076349039+3.74E-050.99996257
LLPHchr1266522675-ADKchr1076349039+2.56E-050.99997437

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for LLPH-ADK


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:66524485/chr10:76349040)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LLPH

Q9BRT6

ADK

P55263

FUNCTION: In hippocampal neurons, regulates dendritic and spine growth and synaptic transmission. {ECO:0000250|UniProtKB:Q9D945}.FUNCTION: ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives. Serves as a potential regulator of concentrations of extracellular adenosine and intracellular adenine nucleotides.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLLPHchr12:66522675chr10:76349039ENST00000266604-233_12570130.0Compositional biasNote=Lys-rich
HgeneLLPHchr12:66522675chr10:76349039ENST00000446587-233_12570130.0Compositional biasNote=Lys-rich
TgeneADKchr12:66522675chr10:76349039ENST000002866216118_16242363.0MotifNuclear localization signal
TgeneADKchr12:66522675chr10:76349039ENST000003727346118_16225346.0MotifNuclear localization signal
TgeneADKchr12:66522675chr10:76349039ENST000005399095108_16185306.0MotifNuclear localization signal
TgeneADKchr12:66522675chr10:76349039ENST000005415505108_16207328.0MotifNuclear localization signal


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Fusion Gene Sequence for LLPH-ADK


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>45708_45708_1_LLPH-ADK_LLPH_chr12_66522675_ENST00000266604_ADK_chr10_76349039_ENST00000286621_length(transcript)=675nt_BP=282nt
GGAAGACGGAAGTGCAAAGACTTCCGGTCGGCGTGAGCGTGAGGTGTGGGTGTTCGTTTCTCAGGTAAAACATGGCTAAAAGCTTACGGA
GTAAGTGGAAAAGAAAGATGCGTGCTGAAAAGAGAAAAAAGAATGCCCCAAAGGAGGCCAGCAGGCTTAAAAGTATTCTCAAACTAGACG
GTGATGTTTTAATGAAAGATGTTCAAGAGATAGCAACTGTGGTGGTACCCAAACCCAAACATTGCCAAGAGAAAATGCAATGTGAGGTAA
AAGATGAAAAAGGAAGCTGCCACTTTTGCTAGAGAGCAAGGCTTTGAGACTAAAGACATTAAAGAGATAGCCAAAAAGACACAAGCCCTG
CCAAAGATGAACTCAAAGAGGCAGCGAATCGTGATCTTCACCCAAGGGAGAGATGACACTATAATGGCTACAGAAAGTGAAGTCACTGCT
TTTGCTGTCTTGGATCAAGACCAGAAAGAAATTATTGATACCAATGGAGCTGGAGATGCATTTGTTGGAGGTTTTCTGTCTCAACTGGTC
TCTGACAAGCCTCTGACTGAATGTATCCGTGCTGGCCACTATGCAGCAAGCATCATAATTAGACGGACTGGCTGCACCTTTCCTGAGAAG

>45708_45708_1_LLPH-ADK_LLPH_chr12_66522675_ENST00000266604_ADK_chr10_76349039_ENST00000286621_length(amino acids)=123AA_BP=3
MKKEAATFAREQGFETKDIKEIAKKTQALPKMNSKRQRIVIFTQGRDDTIMATESEVTAFAVLDQDQKEIIDTNGAGDAFVGGFLSQLVS

--------------------------------------------------------------
>45708_45708_2_LLPH-ADK_LLPH_chr12_66522675_ENST00000266604_ADK_chr10_76349039_ENST00000372734_length(transcript)=1503nt_BP=282nt
GGAAGACGGAAGTGCAAAGACTTCCGGTCGGCGTGAGCGTGAGGTGTGGGTGTTCGTTTCTCAGGTAAAACATGGCTAAAAGCTTACGGA
GTAAGTGGAAAAGAAAGATGCGTGCTGAAAAGAGAAAAAAGAATGCCCCAAAGGAGGCCAGCAGGCTTAAAAGTATTCTCAAACTAGACG
GTGATGTTTTAATGAAAGATGTTCAAGAGATAGCAACTGTGGTGGTACCCAAACCCAAACATTGCCAAGAGAAAATGCAATGTGAGGTAA
AAGATGAAAAAGGAAGCTGCCACTTTTGCTAGAGAGCAAGGCTTTGAGACTAAAGACATTAAAGAGATAGCCAAAAAGACACAAGCCCTG
CCAAAGATGAACTCAAAGAGGCAGCGAATCGTGATCTTCACCCAAGGGAGAGATGACACTATAATGGCTACAGAAAGTGAAGTCACTGCT
TTTGCTGTCTTGGATCAAGACCAGAAAGAAATTATTGATACCAATGGAGCTGGAGATGCATTTGTTGGAGGTTTTCTGTCTCAACTGGTC
TCTGACAAGCCTCTGACTGAATGTATCCGTGCTGGCCACTATGCAGCAAGCATCATAATTAGACGGACTGGCTGCACCTTTCCTGAGAAG
CCAGACTTCCACTGATGGAAGAGCTGAAAACACAAGCCCAGGAGTGCAGACACTGCCCTAATTGCTTCCTGAGAATTCCCATATTAATAA
AGAAGAAAATTATCTGCCATTTTTTCCTACTATAATAATGCTGAATCTTAATTTAGAGGGTACAAGGGTATGGTAATGCTTGTAGAATCT
TTATTATCTCAACAATCTAAAAAATGATGTTTATTTCCATAGTTTGATAGTGCCACTTAAATGCCAATTAAACAAGAATATAACATTTCA
ATAGAAATTTTTATTTCATTTTCAATTACTTTGTAAATTCGTGTGTATTTAGTACACTGATTTGTTTTTTTACATTTCTGCTTTGAATGC
AGATGCAATTTAATATAATAGATTTTTTAATGAATTAATCTTAACATAGTAATCTTTAGCTTTTTATACAAATATATTTAATTTAGGAGT
ATATGTGTGTCTATACACACACATACATAAATATACCACATATACACCTGATAGTCAAATAAGGTACAGAAATTTTATCTTGTCAATTAT
GCCAAATAATCTCTTTAATGTGCACTCAAACATGTAATAAACTTTGGATAATTAAATAATGTGCCAAATTTAAGTTGTACCACAATATTC
AAATCATAGTCTTATGGAACTCTGTAATTGGACACAAACAAAAACTTGTCATATAGGAATTTTTTTCTGTCTTTTCCCTGTGTACAGCAA
ACTGAGGAAGAAAGATCATTATTTAATACTGGGCCCTGAAATGACACCCAATTTGTTAATGGAATTATGAAGAACAGCAATATAATACAC

>45708_45708_2_LLPH-ADK_LLPH_chr12_66522675_ENST00000266604_ADK_chr10_76349039_ENST00000372734_length(amino acids)=123AA_BP=3
MKKEAATFAREQGFETKDIKEIAKKTQALPKMNSKRQRIVIFTQGRDDTIMATESEVTAFAVLDQDQKEIIDTNGAGDAFVGGFLSQLVS

--------------------------------------------------------------
>45708_45708_3_LLPH-ADK_LLPH_chr12_66522675_ENST00000266604_ADK_chr10_76349039_ENST00000539909_length(transcript)=899nt_BP=282nt
GGAAGACGGAAGTGCAAAGACTTCCGGTCGGCGTGAGCGTGAGGTGTGGGTGTTCGTTTCTCAGGTAAAACATGGCTAAAAGCTTACGGA
GTAAGTGGAAAAGAAAGATGCGTGCTGAAAAGAGAAAAAAGAATGCCCCAAAGGAGGCCAGCAGGCTTAAAAGTATTCTCAAACTAGACG
GTGATGTTTTAATGAAAGATGTTCAAGAGATAGCAACTGTGGTGGTACCCAAACCCAAACATTGCCAAGAGAAAATGCAATGTGAGGTAA
AAGATGAAAAAGGAAGCTGCCACTTTTGCTAGAGAGCAAGGCTTTGAGACTAAAGACATTAAAGAGATAGCCAAAAAGACACAAGCCCTG
CCAAAGATGAACTCAAAGAGGCAGCGAATCGTGATCTTCACCCAAGGGAGAGATGACACTATAATGGCTACAGAAAGTGAAGTCACTGCT
TTTGCTGTCTTGGATCAAGACCAGAAAGAAATTATTGATACCAATGGAGCTGGAGATGCATTTGTTGGAGGTTTTCTGTCTCAACTGGTC
TCTGACAAGCCTCTGACTGAATGTATCCGTGCTGGCCACTATGCAGCAAGCATCATAATTAGACGGACTGGCTGCACCTTTCCTGAGAAG
CCAGACTTCCACTGATGGAAGAGCTGAAAACACAAGCCCAGGAGTGCAGACACTGCCCTAATTGCTTCCTGAGAATTCCCATATTAATAA
AGAAGAAAATTATCTGCCATTTTTTCCTACTATAATAATGCTGAATCTTAATTTAGAGGGTACAAGGGTATGGTAATGCTTGTAGAATCT

>45708_45708_3_LLPH-ADK_LLPH_chr12_66522675_ENST00000266604_ADK_chr10_76349039_ENST00000539909_length(amino acids)=123AA_BP=3
MKKEAATFAREQGFETKDIKEIAKKTQALPKMNSKRQRIVIFTQGRDDTIMATESEVTAFAVLDQDQKEIIDTNGAGDAFVGGFLSQLVS

--------------------------------------------------------------
>45708_45708_4_LLPH-ADK_LLPH_chr12_66522675_ENST00000266604_ADK_chr10_76349039_ENST00000541550_length(transcript)=738nt_BP=282nt
GGAAGACGGAAGTGCAAAGACTTCCGGTCGGCGTGAGCGTGAGGTGTGGGTGTTCGTTTCTCAGGTAAAACATGGCTAAAAGCTTACGGA
GTAAGTGGAAAAGAAAGATGCGTGCTGAAAAGAGAAAAAAGAATGCCCCAAAGGAGGCCAGCAGGCTTAAAAGTATTCTCAAACTAGACG
GTGATGTTTTAATGAAAGATGTTCAAGAGATAGCAACTGTGGTGGTACCCAAACCCAAACATTGCCAAGAGAAAATGCAATGTGAGGTAA
AAGATGAAAAAGGAAGCTGCCACTTTTGCTAGAGAGCAAGGCTTTGAGACTAAAGACATTAAAGAGATAGCCAAAAAGACACAAGCCCTG
CCAAAGATGAACTCAAAGAGGCAGCGAATCGTGATCTTCACCCAAGGGAGAGATGACACTATAATGGCTACAGAAAGTGAAGTCACTGCT
TTTGCTGTCTTGGATCAAGACCAGAAAGAAATTATTGATACCAATGGAGCTGGAGATGCATTTGTTGGAGGTTTTCTGTCTCAACTGGTC
TCTGACAAGCCTCTGACTGAATGTATCCGTGCTGGCCACTATGCAGCAAGCATCATAATTAGACGGACTGGCTGCACCTTTCCTGAGAAG
CCAGACTTCCACTGATGGAAGAGCTGAAAACACAAGCCCAGGAGTGCAGACACTGCCCTAATTGCTTCCTGAGAATTCCCATATTAATAA

>45708_45708_4_LLPH-ADK_LLPH_chr12_66522675_ENST00000266604_ADK_chr10_76349039_ENST00000541550_length(amino acids)=123AA_BP=3
MKKEAATFAREQGFETKDIKEIAKKTQALPKMNSKRQRIVIFTQGRDDTIMATESEVTAFAVLDQDQKEIIDTNGAGDAFVGGFLSQLVS

--------------------------------------------------------------
>45708_45708_5_LLPH-ADK_LLPH_chr12_66522675_ENST00000446587_ADK_chr10_76349039_ENST00000286621_length(transcript)=858nt_BP=465nt
GAGTTCGGTTCCTCACCGGTCCAGTGACACATGGGACTTGGGGCTTGATTCCGCCACCCTTGGAGAATTTCGTTTCTTGACACTCGCTGG
GCTATACTTGAGCTCCAGTCCGGAGATGCAGGCCTTGTTGAGGGCGAGGGTTCCCCTTGCTCTTTTTGGTGGGGGCCCTCCGGCTTCCGA
GTGCACTGGATAAAGTGGAGCCCACCCCTGTCGTTCACTCCCGCTGAAGTTAACTTCGGCCCTCAAGGTAAAACATGGCTAAAAGCTTAC
GGAGTAAGTGGAAAAGAAAGATGCGTGCTGAAAAGAGAAAAAAGAATGCCCCAAAGGAGGCCAGCAGGCTTAAAAGTATTCTCAAACTAG
ACGGTGATGTTTTAATGAAAGATGTTCAAGAGATAGCAACTGTGGTGGTACCCAAACCCAAACATTGCCAAGAGAAAATGCAATGTGAGG
TAAAAGATGAAAAAGGAAGCTGCCACTTTTGCTAGAGAGCAAGGCTTTGAGACTAAAGACATTAAAGAGATAGCCAAAAAGACACAAGCC
CTGCCAAAGATGAACTCAAAGAGGCAGCGAATCGTGATCTTCACCCAAGGGAGAGATGACACTATAATGGCTACAGAAAGTGAAGTCACT
GCTTTTGCTGTCTTGGATCAAGACCAGAAAGAAATTATTGATACCAATGGAGCTGGAGATGCATTTGTTGGAGGTTTTCTGTCTCAACTG
GTCTCTGACAAGCCTCTGACTGAATGTATCCGTGCTGGCCACTATGCAGCAAGCATCATAATTAGACGGACTGGCTGCACCTTTCCTGAG

>45708_45708_5_LLPH-ADK_LLPH_chr12_66522675_ENST00000446587_ADK_chr10_76349039_ENST00000286621_length(amino acids)=123AA_BP=3
MKKEAATFAREQGFETKDIKEIAKKTQALPKMNSKRQRIVIFTQGRDDTIMATESEVTAFAVLDQDQKEIIDTNGAGDAFVGGFLSQLVS

--------------------------------------------------------------
>45708_45708_6_LLPH-ADK_LLPH_chr12_66522675_ENST00000446587_ADK_chr10_76349039_ENST00000372734_length(transcript)=1686nt_BP=465nt
GAGTTCGGTTCCTCACCGGTCCAGTGACACATGGGACTTGGGGCTTGATTCCGCCACCCTTGGAGAATTTCGTTTCTTGACACTCGCTGG
GCTATACTTGAGCTCCAGTCCGGAGATGCAGGCCTTGTTGAGGGCGAGGGTTCCCCTTGCTCTTTTTGGTGGGGGCCCTCCGGCTTCCGA
GTGCACTGGATAAAGTGGAGCCCACCCCTGTCGTTCACTCCCGCTGAAGTTAACTTCGGCCCTCAAGGTAAAACATGGCTAAAAGCTTAC
GGAGTAAGTGGAAAAGAAAGATGCGTGCTGAAAAGAGAAAAAAGAATGCCCCAAAGGAGGCCAGCAGGCTTAAAAGTATTCTCAAACTAG
ACGGTGATGTTTTAATGAAAGATGTTCAAGAGATAGCAACTGTGGTGGTACCCAAACCCAAACATTGCCAAGAGAAAATGCAATGTGAGG
TAAAAGATGAAAAAGGAAGCTGCCACTTTTGCTAGAGAGCAAGGCTTTGAGACTAAAGACATTAAAGAGATAGCCAAAAAGACACAAGCC
CTGCCAAAGATGAACTCAAAGAGGCAGCGAATCGTGATCTTCACCCAAGGGAGAGATGACACTATAATGGCTACAGAAAGTGAAGTCACT
GCTTTTGCTGTCTTGGATCAAGACCAGAAAGAAATTATTGATACCAATGGAGCTGGAGATGCATTTGTTGGAGGTTTTCTGTCTCAACTG
GTCTCTGACAAGCCTCTGACTGAATGTATCCGTGCTGGCCACTATGCAGCAAGCATCATAATTAGACGGACTGGCTGCACCTTTCCTGAG
AAGCCAGACTTCCACTGATGGAAGAGCTGAAAACACAAGCCCAGGAGTGCAGACACTGCCCTAATTGCTTCCTGAGAATTCCCATATTAA
TAAAGAAGAAAATTATCTGCCATTTTTTCCTACTATAATAATGCTGAATCTTAATTTAGAGGGTACAAGGGTATGGTAATGCTTGTAGAA
TCTTTATTATCTCAACAATCTAAAAAATGATGTTTATTTCCATAGTTTGATAGTGCCACTTAAATGCCAATTAAACAAGAATATAACATT
TCAATAGAAATTTTTATTTCATTTTCAATTACTTTGTAAATTCGTGTGTATTTAGTACACTGATTTGTTTTTTTACATTTCTGCTTTGAA
TGCAGATGCAATTTAATATAATAGATTTTTTAATGAATTAATCTTAACATAGTAATCTTTAGCTTTTTATACAAATATATTTAATTTAGG
AGTATATGTGTGTCTATACACACACATACATAAATATACCACATATACACCTGATAGTCAAATAAGGTACAGAAATTTTATCTTGTCAAT
TATGCCAAATAATCTCTTTAATGTGCACTCAAACATGTAATAAACTTTGGATAATTAAATAATGTGCCAAATTTAAGTTGTACCACAATA
TTCAAATCATAGTCTTATGGAACTCTGTAATTGGACACAAACAAAAACTTGTCATATAGGAATTTTTTTCTGTCTTTTCCCTGTGTACAG
CAAACTGAGGAAGAAAGATCATTATTTAATACTGGGCCCTGAAATGACACCCAATTTGTTAATGGAATTATGAAGAACAGCAATATAATA

>45708_45708_6_LLPH-ADK_LLPH_chr12_66522675_ENST00000446587_ADK_chr10_76349039_ENST00000372734_length(amino acids)=123AA_BP=3
MKKEAATFAREQGFETKDIKEIAKKTQALPKMNSKRQRIVIFTQGRDDTIMATESEVTAFAVLDQDQKEIIDTNGAGDAFVGGFLSQLVS

--------------------------------------------------------------
>45708_45708_7_LLPH-ADK_LLPH_chr12_66522675_ENST00000446587_ADK_chr10_76349039_ENST00000539909_length(transcript)=1082nt_BP=465nt
GAGTTCGGTTCCTCACCGGTCCAGTGACACATGGGACTTGGGGCTTGATTCCGCCACCCTTGGAGAATTTCGTTTCTTGACACTCGCTGG
GCTATACTTGAGCTCCAGTCCGGAGATGCAGGCCTTGTTGAGGGCGAGGGTTCCCCTTGCTCTTTTTGGTGGGGGCCCTCCGGCTTCCGA
GTGCACTGGATAAAGTGGAGCCCACCCCTGTCGTTCACTCCCGCTGAAGTTAACTTCGGCCCTCAAGGTAAAACATGGCTAAAAGCTTAC
GGAGTAAGTGGAAAAGAAAGATGCGTGCTGAAAAGAGAAAAAAGAATGCCCCAAAGGAGGCCAGCAGGCTTAAAAGTATTCTCAAACTAG
ACGGTGATGTTTTAATGAAAGATGTTCAAGAGATAGCAACTGTGGTGGTACCCAAACCCAAACATTGCCAAGAGAAAATGCAATGTGAGG
TAAAAGATGAAAAAGGAAGCTGCCACTTTTGCTAGAGAGCAAGGCTTTGAGACTAAAGACATTAAAGAGATAGCCAAAAAGACACAAGCC
CTGCCAAAGATGAACTCAAAGAGGCAGCGAATCGTGATCTTCACCCAAGGGAGAGATGACACTATAATGGCTACAGAAAGTGAAGTCACT
GCTTTTGCTGTCTTGGATCAAGACCAGAAAGAAATTATTGATACCAATGGAGCTGGAGATGCATTTGTTGGAGGTTTTCTGTCTCAACTG
GTCTCTGACAAGCCTCTGACTGAATGTATCCGTGCTGGCCACTATGCAGCAAGCATCATAATTAGACGGACTGGCTGCACCTTTCCTGAG
AAGCCAGACTTCCACTGATGGAAGAGCTGAAAACACAAGCCCAGGAGTGCAGACACTGCCCTAATTGCTTCCTGAGAATTCCCATATTAA
TAAAGAAGAAAATTATCTGCCATTTTTTCCTACTATAATAATGCTGAATCTTAATTTAGAGGGTACAAGGGTATGGTAATGCTTGTAGAA
TCTTTATTATCTCAACAATCTAAAAAATGATGTTTATTTCCATAGTTTGATAGTGCCACTTAAATGCCAATTAAACAAGAATATAACATT

>45708_45708_7_LLPH-ADK_LLPH_chr12_66522675_ENST00000446587_ADK_chr10_76349039_ENST00000539909_length(amino acids)=123AA_BP=3
MKKEAATFAREQGFETKDIKEIAKKTQALPKMNSKRQRIVIFTQGRDDTIMATESEVTAFAVLDQDQKEIIDTNGAGDAFVGGFLSQLVS

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>45708_45708_8_LLPH-ADK_LLPH_chr12_66522675_ENST00000446587_ADK_chr10_76349039_ENST00000541550_length(transcript)=921nt_BP=465nt
GAGTTCGGTTCCTCACCGGTCCAGTGACACATGGGACTTGGGGCTTGATTCCGCCACCCTTGGAGAATTTCGTTTCTTGACACTCGCTGG
GCTATACTTGAGCTCCAGTCCGGAGATGCAGGCCTTGTTGAGGGCGAGGGTTCCCCTTGCTCTTTTTGGTGGGGGCCCTCCGGCTTCCGA
GTGCACTGGATAAAGTGGAGCCCACCCCTGTCGTTCACTCCCGCTGAAGTTAACTTCGGCCCTCAAGGTAAAACATGGCTAAAAGCTTAC
GGAGTAAGTGGAAAAGAAAGATGCGTGCTGAAAAGAGAAAAAAGAATGCCCCAAAGGAGGCCAGCAGGCTTAAAAGTATTCTCAAACTAG
ACGGTGATGTTTTAATGAAAGATGTTCAAGAGATAGCAACTGTGGTGGTACCCAAACCCAAACATTGCCAAGAGAAAATGCAATGTGAGG
TAAAAGATGAAAAAGGAAGCTGCCACTTTTGCTAGAGAGCAAGGCTTTGAGACTAAAGACATTAAAGAGATAGCCAAAAAGACACAAGCC
CTGCCAAAGATGAACTCAAAGAGGCAGCGAATCGTGATCTTCACCCAAGGGAGAGATGACACTATAATGGCTACAGAAAGTGAAGTCACT
GCTTTTGCTGTCTTGGATCAAGACCAGAAAGAAATTATTGATACCAATGGAGCTGGAGATGCATTTGTTGGAGGTTTTCTGTCTCAACTG
GTCTCTGACAAGCCTCTGACTGAATGTATCCGTGCTGGCCACTATGCAGCAAGCATCATAATTAGACGGACTGGCTGCACCTTTCCTGAG
AAGCCAGACTTCCACTGATGGAAGAGCTGAAAACACAAGCCCAGGAGTGCAGACACTGCCCTAATTGCTTCCTGAGAATTCCCATATTAA

>45708_45708_8_LLPH-ADK_LLPH_chr12_66522675_ENST00000446587_ADK_chr10_76349039_ENST00000541550_length(amino acids)=123AA_BP=3
MKKEAATFAREQGFETKDIKEIAKKTQALPKMNSKRQRIVIFTQGRDDTIMATESEVTAFAVLDQDQKEIIDTNGAGDAFVGGFLSQLVS

--------------------------------------------------------------

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Fusion Gene PPI Analysis for LLPH-ADK


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for LLPH-ADK


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for LLPH-ADK


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource