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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:LMAN2-KIAA0226 (FusionGDB2 ID:45722)

Fusion Gene Summary for LMAN2-KIAA0226

check button Fusion gene summary
Fusion gene informationFusion gene name: LMAN2-KIAA0226
Fusion gene ID: 45722
HgeneTgene
Gene symbol

LMAN2

KIAA0226

Gene ID

10960

9711

Gene namelectin, mannose binding 2rubicon autophagy regulator
SynonymsC5orf8|GP36B|VIP36KIAA0226|RUBICON|SCAR15
Cytomap

5q35.3

3q29

Type of geneprotein-codingprotein-coding
Descriptionvesicular integral-membrane protein VIP36epididymis secretory sperm binding proteinglycoprotein GP36bvesicular integral protein of 36 kDavesicular integral-membrane protein 36run domain Beclin-1-interacting and cysteine-rich domain-containing proteinRUN and cysteine rich domain containing beclin 1 interacting proteinRUN domain and cysteine-rich domain containing, Beclin 1-interacting proteinbaronbeclin-1 associated RUN dom
Modification date2020031320200313
UniProtAcc

Q12907

.
Ensembl transtripts involved in fusion geneENST00000303127, ENST00000515209, 
ENST00000506310, 		ENST00000449205, 
ENST00000467303, ENST00000273582, 
ENST00000296343, ENST00000389665, 
Fusion gene scores* DoF score10 X 6 X 11=6602 X 2 X 2=8
# samples 112
** MAII scorelog2(11/660*10)=-2.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/8*10)=1.32192809488736
Context

PubMed: LMAN2 [Title/Abstract] AND KIAA0226 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointLMAN2(176761285)-KIAA0226(197411088), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneKIAA0226

GO:0043553

negative regulation of phosphatidylinositol 3-kinase activity

21062745


check buttonFusion gene breakpoints across LMAN2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across KIAA0226 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4UCECTCGA-AJ-A3NH-01ALMAN2chr5

176761285

-KIAA0226chr3

197411088

-


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Fusion Gene ORF analysis for LMAN2-KIAA0226

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000303127ENST00000449205LMAN2chr5

176761285

-KIAA0226chr3

197411088

-
5CDS-intronENST00000303127ENST00000467303LMAN2chr5

176761285

-KIAA0226chr3

197411088

-
5CDS-intronENST00000515209ENST00000449205LMAN2chr5

176761285

-KIAA0226chr3

197411088

-
5CDS-intronENST00000515209ENST00000467303LMAN2chr5

176761285

-KIAA0226chr3

197411088

-
In-frameENST00000303127ENST00000273582LMAN2chr5

176761285

-KIAA0226chr3

197411088

-
In-frameENST00000303127ENST00000296343LMAN2chr5

176761285

-KIAA0226chr3

197411088

-
In-frameENST00000303127ENST00000389665LMAN2chr5

176761285

-KIAA0226chr3

197411088

-
In-frameENST00000515209ENST00000273582LMAN2chr5

176761285

-KIAA0226chr3

197411088

-
In-frameENST00000515209ENST00000296343LMAN2chr5

176761285

-KIAA0226chr3

197411088

-
In-frameENST00000515209ENST00000389665LMAN2chr5

176761285

-KIAA0226chr3

197411088

-
intron-3CDSENST00000506310ENST00000273582LMAN2chr5

176761285

-KIAA0226chr3

197411088

-
intron-3CDSENST00000506310ENST00000296343LMAN2chr5

176761285

-KIAA0226chr3

197411088

-
intron-3CDSENST00000506310ENST00000389665LMAN2chr5

176761285

-KIAA0226chr3

197411088

-
intron-intronENST00000506310ENST00000449205LMAN2chr5

176761285

-KIAA0226chr3

197411088

-
intron-intronENST00000506310ENST00000467303LMAN2chr5

176761285

-KIAA0226chr3

197411088

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000303127LMAN2chr5176761285-ENST00000273582KIAA0226chr3197411088-587311152052247680
ENST00000303127LMAN2chr5176761285-ENST00000296343KIAA0226chr3197411088-224811152052247681
ENST00000303127LMAN2chr5176761285-ENST00000389665KIAA0226chr3197411088-202011152052019605
ENST00000515209LMAN2chr5176761285-ENST00000273582KIAA0226chr3197411088-566891002042680
ENST00000515209LMAN2chr5176761285-ENST00000296343KIAA0226chr3197411088-204391002042680
ENST00000515209LMAN2chr5176761285-ENST00000389665KIAA0226chr3197411088-181591001814604

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000303127ENST00000273582LMAN2chr5176761285-KIAA0226chr3197411088-0.0033669470.9966331
ENST00000303127ENST00000296343LMAN2chr5176761285-KIAA0226chr3197411088-0.021992930.978007
ENST00000303127ENST00000389665LMAN2chr5176761285-KIAA0226chr3197411088-0.0332936270.96670634
ENST00000515209ENST00000273582LMAN2chr5176761285-KIAA0226chr3197411088-0.0029085970.9970914
ENST00000515209ENST00000296343LMAN2chr5176761285-KIAA0226chr3197411088-0.0199343820.98006564
ENST00000515209ENST00000389665LMAN2chr5176761285-KIAA0226chr3197411088-0.031977970.96802205

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Fusion Genomic Features for LMAN2-KIAA0226


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for LMAN2-KIAA0226


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:176761285/chr3:197411088)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LMAN2

Q12907

.
FUNCTION: Plays a role as an intracellular lectin in the early secretory pathway. Interacts with N-acetyl-D-galactosamine and high-mannose type glycans and may also bind to O-linked glycans. Involved in the transport and sorting of glycoproteins carrying high mannose-type glycans (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLMAN2chr5:176761285chr3:197411088ENST00000303127-7852_276303357.0DomainL-type lectin-like
HgeneLMAN2chr5:176761285chr3:197411088ENST00000303127-78164_166303357.0RegionCarbohydrate binding
HgeneLMAN2chr5:176761285chr3:197411088ENST00000303127-78260_262303357.0RegionCarbohydrate binding
TgeneKIAA0226chr5:176761285chr3:197411088ENST000002735821121567_625550928.0Compositional biasNote=Ser-rich
TgeneKIAA0226chr5:176761285chr3:197411088ENST000002735821121881_932550928.0Compositional biasNote=Cys-rich
TgeneKIAA0226chr5:176761285chr3:197411088ENST000002963431020881_932595973.0Compositional biasNote=Cys-rich
TgeneKIAA0226chr5:176761285chr3:197411088ENST000003896651119881_932620922.0Compositional biasNote=Cys-rich

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLMAN2chr5:176761285chr3:197411088ENST00000303127-78346_356303357.0Topological domainCytoplasmic
HgeneLMAN2chr5:176761285chr3:197411088ENST00000303127-7845_322303357.0Topological domainLumenal
HgeneLMAN2chr5:176761285chr3:197411088ENST00000303127-78323_345303357.0TransmembraneHelical
TgeneKIAA0226chr5:176761285chr3:197411088ENST000002735821121204_447550928.0Compositional biasNote=Ser-rich
TgeneKIAA0226chr5:176761285chr3:197411088ENST000002963431020204_447595973.0Compositional biasNote=Ser-rich
TgeneKIAA0226chr5:176761285chr3:197411088ENST000002963431020567_625595973.0Compositional biasNote=Ser-rich
TgeneKIAA0226chr5:176761285chr3:197411088ENST000003896651119204_447620922.0Compositional biasNote=Ser-rich
TgeneKIAA0226chr5:176761285chr3:197411088ENST000003896651119567_625620922.0Compositional biasNote=Ser-rich
TgeneKIAA0226chr5:176761285chr3:197411088ENST00000273582112148_189550928.0DomainRUN
TgeneKIAA0226chr5:176761285chr3:197411088ENST00000296343102048_189595973.0DomainRUN
TgeneKIAA0226chr5:176761285chr3:197411088ENST00000389665111948_189620922.0DomainRUN


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Fusion Gene Sequence for LMAN2-KIAA0226


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>45722_45722_1_LMAN2-KIAA0226_LMAN2_chr5_176761285_ENST00000303127_KIAA0226_chr3_197411088_ENST00000273582_length(transcript)=5873nt_BP=1115nt
CTTGGAGCCTCTAAGGAGATGAAACTGCACTCAACCAGGATGAGAGGCTGCCCGGCCAATGCAGCTGCCGCCCCGTCTGCTGCGGAGGCT
TTGCTTTTTGACTCCCTGGCGACAGTAAAGTTGAAGAGCTTCCGGCCGGAGGCCAATAGATGGGACCCCCGGAAGGCGGAAGTTCTAGGG
CGGAAGTGGCCGAGAGGAGAGGAGAATGGCGGCGGAAGGCTGGATTTGGCGTTGGGGCTGGGGCCGGCGGTGCCTGGGAAGGCCTGGGCT
TCTCGGCCCCGGCCCTGGCCCCACTACACCTCTCTTTCTTCTTTTGTTGTTGGGGTCTGTGACTGCGGATATAACTGACGGCAACAGTGA
ACATCTCAAGCGGGAGCATTCGCTCATTAAGCCCTACCAAGGGGTCGGTTCCAGCTCTATGCCCCTCTGGGACTTCCAGGGCAGCACTAT
GCTCACGAGCCAGTACGTACGTCTGACCCCTGACGAGCGCAGCAAAGAGGGCTCTATCTGGAACCACCAGCCGTGCTTCCTCAAAGACTG
GGAAATGCACGTCCACTTCAAAGTCCACGGCACAGGGAAGAAGAACCTCCATGGAGACGGCATCGCCTTGTGGTACACCCGGGACCGCCT
CGTGCCAGGGCCTGTGTTTGGAAGCAAAGATAACTTCCACGGCTTAGCCATCTTCCTGGACACCTACCCCAATGATGAGACCACTGAGCG
CGTGTTCCCGTACATCTCGGTGATGGTGAACAATGGCTCCCTGTCCTACGACCACAGCAAGGATGGGCGCTGGACCGAGCTGGCGGGCTG
CACGGCTGACTTCCGCAACCGCGATCACGACACCTTCCTGGCTGTGCGCTACTCCCGGGGCCGTCTGACGGTGATGACCGACCTGGAGGA
CAAGAACGAGTGGAAGAACTGCATTGACATCACGGGAGTGCGCCTGCCCACCGGCTACTACTTCGGGGCCTCCGCCGGCACCGGCGACCT
GTCTGACAATCATGACATCATCTCCATGAAGCTGTTCCAGCTGATGGTGGAGCACACGCCCGACGAGGAGAGCATCGACTGGACCAAGAT
CGAGCCCAGCGTCAACTTCCTCAAGTCGCCCAAAGATGCTGACATCAGAAGGAACACAGCCTCAAGCAGCAAATCCTTCGTTTCCTCCCA
GTCCTTCTCCCACTGCTTCCTGCACTCCACGTCTGCTGAGGCGGTGGCCATGGGGCTCCTGAAGCAGTTTGAGGGGATGCAGCTTCCAGC
CGCCTCGGAGCTGGAGTGGCTTGTCCCGGAGCATGATGCCCCTCAGAAGCTCCTGCCCATTCCTGACTCACTGCCCATCTCACCGGATGA
CGGGCAGCACGCTGACATCTACAAGCTGCGGATTCGTGTTCGTGGCAACTTGGAGTGGGCCCCGCCCCGGCCTCAGATAATTTTTAATGT
TCATCCAGCCCCAACGAGGAAAATTGCCGTGGCCAAGCAGAATTACCGCTGTGCAGGATGTGGCATCCGGACTGACCCTGATTACATCAA
GCGACTGCGGTACTGTGAGTACCTGGGCAAGTACTTCTGCCAGTGCTGCCACGAGAATGCCCAGATGGCCATCCCCAGCCGGGTTCTGCG
CAAGTGGGACTTCAGCAAGTACTACGTCAGCAACTTCTCCAAGGACCTGCTCATTAAGATCTGGAATGATCCTCTCTTCAACGTGCAGGA
CATAAACAGTGCCCTCTATAGGAAGGTCAAGCTGCTCAATCAAGTCCGGCTGCTGCGGGTCCAGCTGTGTCACATGAAGAACATGTTCAA
GACTTGCCGACTGGCCAAGGAGCTTCTGGATTCCTTTGACACAGTCCCAGGCCACCTGACAGAGGACCTCCACCTGTACTCACTGAATGA
CCTGACTGCGACCAGGAAGGGGGAGCTGGGGCCCCGGCTTGCTGAGCTCACCAGGGCAGGGGCTACCCATGTGGAGAGATGCATGCTCTG
CCAAGCCAAAGGCTTCATCTGTGAGTTCTGTCAGAATGAGGATGACATCATCTTTCCCTTTGAGCTCCATAAGTGCCGGACCTGTGAAGA
GTGTAAAGCGTGTTACCATAAAGCCTGCTTCAAGTCTGGAAGCTGTCCGCGCTGCGAGCGGCTGCAGGCCCGGCGGGAGGCACTGGCCAG
GCAGAGCCTGGAGTCTTACCTGTCAGACTACGAGGAGGAGCCCGCGGAAGCGCTGGCCCTGGAAGCCGCCGTCCTGGAGGCCACCTGAAG
AAAGCACGTGCAGCCCTCCCTCCGGGCCGGGTCACACCTGTTGCAGAACTGAGCCACTCTTTGAAGGACTCGCCCCACCTGGGGCTTCTT
TTTTTTTTTTTTTTTTTAATTATCATCATCTTTTTTTTTTTTTTTACTGACTTGTCTGACGTCTGTGTGCAGTCAGCCGTCGGCAGGTTG
ATGGGTCCAGAGTCTGTGGTGACAGATAATTTGTAAACACCAGGTGTTTCCATCAGAACTGACATGCGGGTCCTTCAGTGAAGCTTCTAG
TGCCTCTGTCAGTGGAAGAGACAGCAAGACCAAGTTCTTCCAGCGTCTGTGGCCTTCTCCTCTAGGTTTCACCTGCATGTCAGGTATCAT
TTCCAATTTTCCTTTGTTTCAGTTCTGGAGCTTCTGAGCCAGGCCTTTCTCAACCACCTCTCCTGCTGCTGAAACGGGGATGGCGTTTTC
CCTCTCCCTGTCCTGGACTGGGGTCAGACTGTGCCCCGAGGAGAAGCAGCAGAGAATAGGACTACGTCATGGGCATTTCGTCCACTTATT
TGGGTATTTTGGGGGCCACAGAACAATCCTGACTATCCTAGACTCCTCAGAGACCTCAGAGGCAGCTGTGAATGTCCCTATGTTGCCGGG
AGTTCCTGTTTGAAATATTTGAAGCATAGAGGATGCCACAAGCTGACTTTCTTCATCTACCTTGGTGATCTTGAAGCAAAGAACAGAACT
GATGCTCAGGCCAGGCTCACCTGTAGCCTTACGCCGCAAGCATACGTGAGGCGCCAGCTCTGTCGCTGAAGGAGCGCTTACTCAGAGGAG
CGGTCGGCCCCCTCTTGGTGTTAAGGTCTCTTAGTTAACCTGGCTTTTTGGTGCAGGTGTGATCTTTGAAGCTCAGGCAGGTCCCTGATG
CCATCCTAAGGTGAGGACAGGAACCTCACCCACCATCTTCTTAGCGTGTCCCTGATGACTCTGTCCTCTGTTAGATGGTCGTTGTGCTTC
TGAGTAAAAGTACAACCCGACTCCGTTCTCTCCCCTTCCTGCAGCAGAGCTGGGTCCTTCCCTGGTGGCCGAGTCTCTCTTGCCTTAGCT
TCTTTGGTCAAAGTTGGAGAAAAGCTTCCTGCTATTAGTGCTGTTACAGAACTTGACGGTTTGTGGATGTGAGTGTGAATGTCCCTGTGT
TCTTGGGATAACAAGAGCCTTTATGCCAATTATGCACTTAACTCTGTGTAGCCTGGTAATGTTTATCTGTTCATTTGATAATGCTGATTT
TAGTGTGCTGCCCCCCTCCCCCCGTTAATGTGTGTTGATGGTGAAGTCCTTTTGATAATGCTGATTTTGGTGTGCTGCCTCCCCCTTCCC
CCCCGTTAATGTGTGTGTTGACAGTGAAGTCCTTGGGTGGGGCCATGTGTGTGTTTGTGATGTTCCTTAAGTTGATGCAGCTTCTAACCT
CTGTGAAAACACTGGTCAGAGTGGCTTCTCCAAGAGCTGGCAGCTCTGTGAACTAAAGCCTGCATCATTTTTGTTCTGGGATTGAATTCT
GCCCATGGGCATGTCTTCTCATAGTTGCTTGCTGGTAGGAAAGAAATGGGCGTGGGTGCTGCCCTGGAAGCTGAGCGGAAAGTTGCCTGT
GGTTGGTGGAAGCTGATGAGAGCTTGAGCTGGCGGTAAGAAGGAGTCTCCCAGGGAAGTGGGAGAGGCATTAAGGTGATGGCCAGGGCTG
AGGCTCCACCAGCGTGAGAGGGAACATGTGGGAACTGGCCCCTGCCCTTGATTCCTCTGCCTCAAAGTTGGGATCTGAAAGCCATGTAGG
GCTAGAAGACCCTGAGGCTGTTCTCCCTTCTGTTCATAGTGAGACTCAAAAAGCCAAGTCCCAGAAGTTCTGAAGGGCTGTGACTAGAAG
TGCCCAGGTCCTTCAGGGAGCTTTAAGAATGACCCCACAGAACTCAAGTTTAACTAGGGGTTAGGTCCCAGATTCAGACCCAGGAGTTTA
TAAAAATGAGCTCTACTTCCAGTTTTGGTTTAAATTACACATCCAGGCCAGGCACAGTGGCTCACACCTGTAATCCCAGCACTTTGGGAG
GCCAGTGCGGGCGGATCATGAGGTCAGGAGTTTGAGACCAGCCTGGCCAATGTGGTGAAACCCTGTCTCTTCCAAAAATACAAAAATTAG
CTGGGCGTGGTGGCACACGCCTGTAATCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATCGCTTGAACCTGGGAGGCAGAGGTTGCAGTG
AGCCGAGATTGCGCCACCGCACTCCAGCCTGGGTGACAGAGTGAGACTCCGTCTCAAAAAACAAAAAGGTGACACATCCAGCTCTTTCTC
CAGGTCACTGCGCTGGAGGACAGATGTGCCGTCTTGTCCTGCCTGTTTCACATCAGCATAGGATCAAAGGATGACAATGCTGACAGCTTC
TGAAGCCGAACTCAACAGTCTCATAGGCTCCTCACTTGTCACTTATTTTTCCCTAGCTCCCTCAACCGCACCCCATCCCTTTAGATCGTG
CGTCTGTTTTAGTGACTCTGACACGATGCCGTCCTCACCTTCCAAATACCCAGTTATTTATTCAAGAGGGGGGAAGTGGGTAGAGGATGG
GATGTTTTGGAAGCACTTTGCAAGTTACCACTATCTGAAAATCCCCTGCTGTTGCGGGGAGAAGCTTTGAATGCACTGAAGAGAATTCCT
TCTAAATGAAGGCAGGTGATAGTGTTCTTTCTGTAAGTAAAGGGAAAGAAAAAAAACATAGTTTGCTTACCAGGTGGAGACAAGATTCAA
GACATAGCAGAAGAGTGGAAGACAAATATTTTCCACTTAAATGAGGCTGTTTTTGACGTTCTCTGCCAAGGATTTAGAGCTTTCGTTGAA
CTAACATAAAAGGAGTGCGAGTCTTAGTAGAGATGTTCCGTGTGTGCCGCCCGTGCTCTGAACTGCGTTTCCACCTGCTGTGGTGCTTGT
GCAGCCTGGCAGTTCATTGTCATCTTTAATAAACTAAGGAAATAAAATTCTGTCTTTCGTCAGCCTGCCTTGACTGTCAAGAAATGGCAT
GTGTCCACTGTAAAGCAGGTATATCTGAACATTGAGAAGGTTTCTGTGTTATAATGTAAAGCAAACTGGACCACACACATCAAGGAAAGT
GAGGTGGAGTGGCTGTGTCTCTAACTTGCCATGAGACCTCGAGCGAACCACTTCACTTCTCTGGGTTTCTGGTGCATGGTGTAACTGTCA
CTTAAAATGAGGTGTCTTCCTCTCCGCAACATCTGACTTGCCTTAGATGCTTCAGTTCCCACTTCTGTGAGCAGCTAGCATCTTTCTCTT
CTGCTCCTGGCCCACTGGAGCTCCAGCTCTACGCTGCAACTCTCTCAACATTTCCCCTTAAATGTCCCCTTGTCATCTCCAACCAGTGTG
TCTAAAACCAGCATAAATTCCGTATTTCCAAAAACCTAACCATTAGTCACCCAGGTTTGAAAATTAATTGTCTTCAACTTCCTCTGTAAG
TGGCACACTGAGCTCATCACGCATCGTCTCATTCCTACTCCCTGTCATCAAGTTCTGTGGATGTTTTCCTCTAAAATAAATCTCTCATTA

>45722_45722_1_LMAN2-KIAA0226_LMAN2_chr5_176761285_ENST00000303127_KIAA0226_chr3_197411088_ENST00000273582_length(amino acids)=680AA_BP=303
MAAEGWIWRWGWGRRCLGRPGLLGPGPGPTTPLFLLLLLGSVTADITDGNSEHLKREHSLIKPYQGVGSSSMPLWDFQGSTMLTSQYVRL
TPDERSKEGSIWNHQPCFLKDWEMHVHFKVHGTGKKNLHGDGIALWYTRDRLVPGPVFGSKDNFHGLAIFLDTYPNDETTERVFPYISVM
VNNGSLSYDHSKDGRWTELAGCTADFRNRDHDTFLAVRYSRGRLTVMTDLEDKNEWKNCIDITGVRLPTGYYFGASAGTGDLSDNHDIIS
MKLFQLMVEHTPDEESIDWTKIEPSVNFLKSPKDADIRRNTASSSKSFVSSQSFSHCFLHSTSAEAVAMGLLKQFEGMQLPAASELEWLV
PEHDAPQKLLPIPDSLPISPDDGQHADIYKLRIRVRGNLEWAPPRPQIIFNVHPAPTRKIAVAKQNYRCAGCGIRTDPDYIKRLRYCEYL
GKYFCQCCHENAQMAIPSRVLRKWDFSKYYVSNFSKDLLIKIWNDPLFNVQDINSALYRKVKLLNQVRLLRVQLCHMKNMFKTCRLAKEL
LDSFDTVPGHLTEDLHLYSLNDLTATRKGELGPRLAELTRAGATHVERCMLCQAKGFICEFCQNEDDIIFPFELHKCRTCEECKACYHKA

--------------------------------------------------------------
>45722_45722_2_LMAN2-KIAA0226_LMAN2_chr5_176761285_ENST00000303127_KIAA0226_chr3_197411088_ENST00000296343_length(transcript)=2248nt_BP=1115nt
CTTGGAGCCTCTAAGGAGATGAAACTGCACTCAACCAGGATGAGAGGCTGCCCGGCCAATGCAGCTGCCGCCCCGTCTGCTGCGGAGGCT
TTGCTTTTTGACTCCCTGGCGACAGTAAAGTTGAAGAGCTTCCGGCCGGAGGCCAATAGATGGGACCCCCGGAAGGCGGAAGTTCTAGGG
CGGAAGTGGCCGAGAGGAGAGGAGAATGGCGGCGGAAGGCTGGATTTGGCGTTGGGGCTGGGGCCGGCGGTGCCTGGGAAGGCCTGGGCT
TCTCGGCCCCGGCCCTGGCCCCACTACACCTCTCTTTCTTCTTTTGTTGTTGGGGTCTGTGACTGCGGATATAACTGACGGCAACAGTGA
ACATCTCAAGCGGGAGCATTCGCTCATTAAGCCCTACCAAGGGGTCGGTTCCAGCTCTATGCCCCTCTGGGACTTCCAGGGCAGCACTAT
GCTCACGAGCCAGTACGTACGTCTGACCCCTGACGAGCGCAGCAAAGAGGGCTCTATCTGGAACCACCAGCCGTGCTTCCTCAAAGACTG
GGAAATGCACGTCCACTTCAAAGTCCACGGCACAGGGAAGAAGAACCTCCATGGAGACGGCATCGCCTTGTGGTACACCCGGGACCGCCT
CGTGCCAGGGCCTGTGTTTGGAAGCAAAGATAACTTCCACGGCTTAGCCATCTTCCTGGACACCTACCCCAATGATGAGACCACTGAGCG
CGTGTTCCCGTACATCTCGGTGATGGTGAACAATGGCTCCCTGTCCTACGACCACAGCAAGGATGGGCGCTGGACCGAGCTGGCGGGCTG
CACGGCTGACTTCCGCAACCGCGATCACGACACCTTCCTGGCTGTGCGCTACTCCCGGGGCCGTCTGACGGTGATGACCGACCTGGAGGA
CAAGAACGAGTGGAAGAACTGCATTGACATCACGGGAGTGCGCCTGCCCACCGGCTACTACTTCGGGGCCTCCGCCGGCACCGGCGACCT
GTCTGACAATCATGACATCATCTCCATGAAGCTGTTCCAGCTGATGGTGGAGCACACGCCCGACGAGGAGAGCATCGACTGGACCAAGAT
CGAGCCCAGCGTCAACTTCCTCAAGTCGCCCAAAGATGCTGACATCAGAAGGAACACAGCCTCAAGCAGCAAATCCTTCGTTTCCTCCCA
GTCCTTCTCCCACTGCTTCCTGCACTCCACGTCTGCTGAGGCGGTGGCCATGGGGCTCCTGAAGCAGTTTGAGGGGATGCAGCTTCCAGC
CGCCTCGGAGCTGGAGTGGCTTGTCCCGGAGCATGATGCCCCTCAGAAGCTCCTGCCCATTCCTGACTCACTGCCCATCTCACCGGATGA
CGGGCAGCACGCTGACATCTACAAGCTGCGGATTCGTGTTCGTGGCAACTTGGAGTGGGCCCCGCCCCGGCCTCAGATAATTTTTAATGT
TCATCCAGCCCCAACGAGGAAAATTGCCGTGGCCAAGCAGAATTACCGCTGTGCAGGATGTGGCATCCGGACTGACCCTGATTACATCAA
GCGACTGCGGTACTGTGAGTACCTGGGCAAGTACTTCTGCCAGTGCTGCCACGAGAATGCCCAGATGGCCATCCCCAGCCGGGTTCTGCG
CAAGTGGGACTTCAGCAAGTACTACGTCAGCAACTTCTCCAAGGACCTGCTCATTAAGATCTGGAATGATCCTCTCTTCAACGTGCAGGA
CATAAACAGTGCCCTCTATAGGAAGGTCAAGCTGCTCAATCAAGTCCGGCTGCTGCGGGTCCAGCTGTGTCACATGAAGAACATGTTCAA
GACTTGCCGACTGGCCAAGGAGCTTCTGGATTCCTTTGACACAGTCCCAGGCCACCTGACAGAGGACCTCCACCTGTACTCACTGAATGA
CCTGACTGCGACCAGGAAGGGGGAGCTGGGGCCCCGGCTTGCTGAGCTCACCAGGGCAGGGGCTACCCATGTGGAGAGATGCATGCTCTG
CCAAGCCAAAGGCTTCATCTGTGAGTTCTGTCAGAATGAGGATGACATCATCTTTCCCTTTGAGCTCCATAAGTGCCGGACCTGTGAAGA
GTGTAAAGCGTGTTACCATAAAGCCTGCTTCAAGTCTGGAAGCTGTCCGCGCTGCGAGCGGCTGCAGGCCCGGCGGGAGGCACTGGCCAG

>45722_45722_2_LMAN2-KIAA0226_LMAN2_chr5_176761285_ENST00000303127_KIAA0226_chr3_197411088_ENST00000296343_length(amino acids)=681AA_BP=303
MAAEGWIWRWGWGRRCLGRPGLLGPGPGPTTPLFLLLLLGSVTADITDGNSEHLKREHSLIKPYQGVGSSSMPLWDFQGSTMLTSQYVRL
TPDERSKEGSIWNHQPCFLKDWEMHVHFKVHGTGKKNLHGDGIALWYTRDRLVPGPVFGSKDNFHGLAIFLDTYPNDETTERVFPYISVM
VNNGSLSYDHSKDGRWTELAGCTADFRNRDHDTFLAVRYSRGRLTVMTDLEDKNEWKNCIDITGVRLPTGYYFGASAGTGDLSDNHDIIS
MKLFQLMVEHTPDEESIDWTKIEPSVNFLKSPKDADIRRNTASSSKSFVSSQSFSHCFLHSTSAEAVAMGLLKQFEGMQLPAASELEWLV
PEHDAPQKLLPIPDSLPISPDDGQHADIYKLRIRVRGNLEWAPPRPQIIFNVHPAPTRKIAVAKQNYRCAGCGIRTDPDYIKRLRYCEYL
GKYFCQCCHENAQMAIPSRVLRKWDFSKYYVSNFSKDLLIKIWNDPLFNVQDINSALYRKVKLLNQVRLLRVQLCHMKNMFKTCRLAKEL
LDSFDTVPGHLTEDLHLYSLNDLTATRKGELGPRLAELTRAGATHVERCMLCQAKGFICEFCQNEDDIIFPFELHKCRTCEECKACYHKA

--------------------------------------------------------------
>45722_45722_3_LMAN2-KIAA0226_LMAN2_chr5_176761285_ENST00000303127_KIAA0226_chr3_197411088_ENST00000389665_length(transcript)=2020nt_BP=1115nt
CTTGGAGCCTCTAAGGAGATGAAACTGCACTCAACCAGGATGAGAGGCTGCCCGGCCAATGCAGCTGCCGCCCCGTCTGCTGCGGAGGCT
TTGCTTTTTGACTCCCTGGCGACAGTAAAGTTGAAGAGCTTCCGGCCGGAGGCCAATAGATGGGACCCCCGGAAGGCGGAAGTTCTAGGG
CGGAAGTGGCCGAGAGGAGAGGAGAATGGCGGCGGAAGGCTGGATTTGGCGTTGGGGCTGGGGCCGGCGGTGCCTGGGAAGGCCTGGGCT
TCTCGGCCCCGGCCCTGGCCCCACTACACCTCTCTTTCTTCTTTTGTTGTTGGGGTCTGTGACTGCGGATATAACTGACGGCAACAGTGA
ACATCTCAAGCGGGAGCATTCGCTCATTAAGCCCTACCAAGGGGTCGGTTCCAGCTCTATGCCCCTCTGGGACTTCCAGGGCAGCACTAT
GCTCACGAGCCAGTACGTACGTCTGACCCCTGACGAGCGCAGCAAAGAGGGCTCTATCTGGAACCACCAGCCGTGCTTCCTCAAAGACTG
GGAAATGCACGTCCACTTCAAAGTCCACGGCACAGGGAAGAAGAACCTCCATGGAGACGGCATCGCCTTGTGGTACACCCGGGACCGCCT
CGTGCCAGGGCCTGTGTTTGGAAGCAAAGATAACTTCCACGGCTTAGCCATCTTCCTGGACACCTACCCCAATGATGAGACCACTGAGCG
CGTGTTCCCGTACATCTCGGTGATGGTGAACAATGGCTCCCTGTCCTACGACCACAGCAAGGATGGGCGCTGGACCGAGCTGGCGGGCTG
CACGGCTGACTTCCGCAACCGCGATCACGACACCTTCCTGGCTGTGCGCTACTCCCGGGGCCGTCTGACGGTGATGACCGACCTGGAGGA
CAAGAACGAGTGGAAGAACTGCATTGACATCACGGGAGTGCGCCTGCCCACCGGCTACTACTTCGGGGCCTCCGCCGGCACCGGCGACCT
GTCTGACAATCATGACATCATCTCCATGAAGCTGTTCCAGCTGATGGTGGAGCACACGCCCGACGAGGAGAGCATCGACTGGACCAAGAT
CGAGCCCAGCGTCAACTTCCTCAAGTCGCCCAAAGATGCTGACATCAGAAGGAACACAGCCTCAAGCAGCAAATCCTTCGTTTCCTCCCA
GTCCTTCTCCCACTGCTTCCTGCACTCCACGTCTGCTGAGGCGGTGGCCATGGGGCTCCTGAAGCAGTTTGAGGGGATGCAGCTTCCAGC
CGCCTCGGAGCTGGAGTGGCTTGTCCCGGAGCATGATGCCCCTCAGAAGCTCCTGCCCATTCCTGACTCACTGCCCATCTCACCGGATGA
CGGGCAGCACGCTGACATCTACAAGCTGCGGATTCGTGTTCGTGGCAACTTGGAGTGGGCCCCGCCCCGGCCTCAGATAATTTTTAATGT
TCATCCAGCCCCAACGAGGAAAATTGCCGTGGCCAAGCAGAATTACCGCTGTGCAGGATGTGGCATCCGGACTGACCCTGATTACATCAA
GCGACTGCGGTACTGTGAGTACCTGGGCAAGTACTTCTGCCAGTGCTGCCACGAGAATGCCCAGATGGCCATCCCCAGCCGGGTTCTGCG
CAAGTGGGACTTCAGCAAGTACTACGTCAGCAACTTCTCCAAGGACCTGCTCATTAAGATCTGGAATGATCCTCTCTTCAACGTGCAGGA
CATAAACAGTGCCCTCTATAGGAAGGTCAAGCTGCTCAATCAAGTCCGGCTGCTGCGGGTCCAGCTGTGTCACATGAAGAACATGTTCAA
GACTTGCCGACTGGCCAAGGAGCTTCTGGATTCCTTTGACACAGTCCCAGGCCACCTGACAGAGGACCTCCACCTGTACTCACTGAATGA
CCTGACTGCGACCAGGAAGGGGGAGCTGGGGCCCCGGCTTGCTGAGCTCACCAGGGCAGGGGCTACCCATGTGGAGAGATGCATGGTGAG

>45722_45722_3_LMAN2-KIAA0226_LMAN2_chr5_176761285_ENST00000303127_KIAA0226_chr3_197411088_ENST00000389665_length(amino acids)=605AA_BP=303
MAAEGWIWRWGWGRRCLGRPGLLGPGPGPTTPLFLLLLLGSVTADITDGNSEHLKREHSLIKPYQGVGSSSMPLWDFQGSTMLTSQYVRL
TPDERSKEGSIWNHQPCFLKDWEMHVHFKVHGTGKKNLHGDGIALWYTRDRLVPGPVFGSKDNFHGLAIFLDTYPNDETTERVFPYISVM
VNNGSLSYDHSKDGRWTELAGCTADFRNRDHDTFLAVRYSRGRLTVMTDLEDKNEWKNCIDITGVRLPTGYYFGASAGTGDLSDNHDIIS
MKLFQLMVEHTPDEESIDWTKIEPSVNFLKSPKDADIRRNTASSSKSFVSSQSFSHCFLHSTSAEAVAMGLLKQFEGMQLPAASELEWLV
PEHDAPQKLLPIPDSLPISPDDGQHADIYKLRIRVRGNLEWAPPRPQIIFNVHPAPTRKIAVAKQNYRCAGCGIRTDPDYIKRLRYCEYL
GKYFCQCCHENAQMAIPSRVLRKWDFSKYYVSNFSKDLLIKIWNDPLFNVQDINSALYRKVKLLNQVRLLRVQLCHMKNMFKTCRLAKEL

--------------------------------------------------------------
>45722_45722_4_LMAN2-KIAA0226_LMAN2_chr5_176761285_ENST00000515209_KIAA0226_chr3_197411088_ENST00000273582_length(transcript)=5668nt_BP=910nt
ATGGCGGCGGAAGGCTGGATTTGGCGTTGGGGCTGGGGCCGGCGGTGCCTGGGAAGGCCTGGGCTTCTCGGCCCCGGCCCTGGCCCCACT
ACACCTCTCTTTCTTCTTTTGTTGTTGGGGTCTGTGACTGCGGATATAACTGACGGCAACAGTGAACATCTCAAGCGGGAGCATTCGCTC
ATTAAGCCCTACCAAGGGGTCGGTTCCAGCTCTATGCCCCTCTGGGACTTCCAGGGCAGCACTATGCTCACGAGCCAGTACGTACGTCTG
ACCCCTGACGAGCGCAGCAAAGAGGGCTCTATCTGGAACCACCAGCCGTGCTTCCTCAAAGACTGGGAAATGCACGTCCACTTCAAAGTC
CACGGCACAGGGAAGAAGAACCTCCATGGAGACGGCATCGCCTTGTGGTACACCCGGGACCGCCTCGTGCCAGGGCCTGTGTTTGGAAGC
AAAGATAACTTCCACGGCTTAGCCATCTTCCTGGACACCTACCCCAATGATGAGACCACTGAGCGCGTGTTCCCGTACATCTCGGTGATG
GTGAACAATGGCTCCCTGTCCTACGACCACAGCAAGGATGGGCGCTGGACCGAGCTGGCGGGCTGCACGGCTGACTTCCGCAACCGCGAT
CACGACACCTTCCTGGCTGTGCGCTACTCCCGGGGCCGTCTGACGGTGATGACCGACCTGGAGGACAAGAACGAGTGGAAGAACTGCATT
GACATCACGGGAGTGCGCCTGCCCACCGGCTACTACTTCGGGGCCTCCGCCGGCACCGGCGACCTGTCTGACAATCATGACATCATCTCC
ATGAAGCTGTTCCAGCTGATGGTGGAGCACACGCCCGACGAGGAGAGCATCGACTGGACCAAGATCGAGCCCAGCGTCAACTTCCTCAAG
TCGCCCAAAGATGCTGACATCAGAAGGAACACAGCCTCAAGCAGCAAATCCTTCGTTTCCTCCCAGTCCTTCTCCCACTGCTTCCTGCAC
TCCACGTCTGCTGAGGCGGTGGCCATGGGGCTCCTGAAGCAGTTTGAGGGGATGCAGCTTCCAGCCGCCTCGGAGCTGGAGTGGCTTGTC
CCGGAGCATGATGCCCCTCAGAAGCTCCTGCCCATTCCTGACTCACTGCCCATCTCACCGGATGACGGGCAGCACGCTGACATCTACAAG
CTGCGGATTCGTGTTCGTGGCAACTTGGAGTGGGCCCCGCCCCGGCCTCAGATAATTTTTAATGTTCATCCAGCCCCAACGAGGAAAATT
GCCGTGGCCAAGCAGAATTACCGCTGTGCAGGATGTGGCATCCGGACTGACCCTGATTACATCAAGCGACTGCGGTACTGTGAGTACCTG
GGCAAGTACTTCTGCCAGTGCTGCCACGAGAATGCCCAGATGGCCATCCCCAGCCGGGTTCTGCGCAAGTGGGACTTCAGCAAGTACTAC
GTCAGCAACTTCTCCAAGGACCTGCTCATTAAGATCTGGAATGATCCTCTCTTCAACGTGCAGGACATAAACAGTGCCCTCTATAGGAAG
GTCAAGCTGCTCAATCAAGTCCGGCTGCTGCGGGTCCAGCTGTGTCACATGAAGAACATGTTCAAGACTTGCCGACTGGCCAAGGAGCTT
CTGGATTCCTTTGACACAGTCCCAGGCCACCTGACAGAGGACCTCCACCTGTACTCACTGAATGACCTGACTGCGACCAGGAAGGGGGAG
CTGGGGCCCCGGCTTGCTGAGCTCACCAGGGCAGGGGCTACCCATGTGGAGAGATGCATGCTCTGCCAAGCCAAAGGCTTCATCTGTGAG
TTCTGTCAGAATGAGGATGACATCATCTTTCCCTTTGAGCTCCATAAGTGCCGGACCTGTGAAGAGTGTAAAGCGTGTTACCATAAAGCC
TGCTTCAAGTCTGGAAGCTGTCCGCGCTGCGAGCGGCTGCAGGCCCGGCGGGAGGCACTGGCCAGGCAGAGCCTGGAGTCTTACCTGTCA
GACTACGAGGAGGAGCCCGCGGAAGCGCTGGCCCTGGAAGCCGCCGTCCTGGAGGCCACCTGAAGAAAGCACGTGCAGCCCTCCCTCCGG
GCCGGGTCACACCTGTTGCAGAACTGAGCCACTCTTTGAAGGACTCGCCCCACCTGGGGCTTCTTTTTTTTTTTTTTTTTTTAATTATCA
TCATCTTTTTTTTTTTTTTTACTGACTTGTCTGACGTCTGTGTGCAGTCAGCCGTCGGCAGGTTGATGGGTCCAGAGTCTGTGGTGACAG
ATAATTTGTAAACACCAGGTGTTTCCATCAGAACTGACATGCGGGTCCTTCAGTGAAGCTTCTAGTGCCTCTGTCAGTGGAAGAGACAGC
AAGACCAAGTTCTTCCAGCGTCTGTGGCCTTCTCCTCTAGGTTTCACCTGCATGTCAGGTATCATTTCCAATTTTCCTTTGTTTCAGTTC
TGGAGCTTCTGAGCCAGGCCTTTCTCAACCACCTCTCCTGCTGCTGAAACGGGGATGGCGTTTTCCCTCTCCCTGTCCTGGACTGGGGTC
AGACTGTGCCCCGAGGAGAAGCAGCAGAGAATAGGACTACGTCATGGGCATTTCGTCCACTTATTTGGGTATTTTGGGGGCCACAGAACA
ATCCTGACTATCCTAGACTCCTCAGAGACCTCAGAGGCAGCTGTGAATGTCCCTATGTTGCCGGGAGTTCCTGTTTGAAATATTTGAAGC
ATAGAGGATGCCACAAGCTGACTTTCTTCATCTACCTTGGTGATCTTGAAGCAAAGAACAGAACTGATGCTCAGGCCAGGCTCACCTGTA
GCCTTACGCCGCAAGCATACGTGAGGCGCCAGCTCTGTCGCTGAAGGAGCGCTTACTCAGAGGAGCGGTCGGCCCCCTCTTGGTGTTAAG
GTCTCTTAGTTAACCTGGCTTTTTGGTGCAGGTGTGATCTTTGAAGCTCAGGCAGGTCCCTGATGCCATCCTAAGGTGAGGACAGGAACC
TCACCCACCATCTTCTTAGCGTGTCCCTGATGACTCTGTCCTCTGTTAGATGGTCGTTGTGCTTCTGAGTAAAAGTACAACCCGACTCCG
TTCTCTCCCCTTCCTGCAGCAGAGCTGGGTCCTTCCCTGGTGGCCGAGTCTCTCTTGCCTTAGCTTCTTTGGTCAAAGTTGGAGAAAAGC
TTCCTGCTATTAGTGCTGTTACAGAACTTGACGGTTTGTGGATGTGAGTGTGAATGTCCCTGTGTTCTTGGGATAACAAGAGCCTTTATG
CCAATTATGCACTTAACTCTGTGTAGCCTGGTAATGTTTATCTGTTCATTTGATAATGCTGATTTTAGTGTGCTGCCCCCCTCCCCCCGT
TAATGTGTGTTGATGGTGAAGTCCTTTTGATAATGCTGATTTTGGTGTGCTGCCTCCCCCTTCCCCCCCGTTAATGTGTGTGTTGACAGT
GAAGTCCTTGGGTGGGGCCATGTGTGTGTTTGTGATGTTCCTTAAGTTGATGCAGCTTCTAACCTCTGTGAAAACACTGGTCAGAGTGGC
TTCTCCAAGAGCTGGCAGCTCTGTGAACTAAAGCCTGCATCATTTTTGTTCTGGGATTGAATTCTGCCCATGGGCATGTCTTCTCATAGT
TGCTTGCTGGTAGGAAAGAAATGGGCGTGGGTGCTGCCCTGGAAGCTGAGCGGAAAGTTGCCTGTGGTTGGTGGAAGCTGATGAGAGCTT
GAGCTGGCGGTAAGAAGGAGTCTCCCAGGGAAGTGGGAGAGGCATTAAGGTGATGGCCAGGGCTGAGGCTCCACCAGCGTGAGAGGGAAC
ATGTGGGAACTGGCCCCTGCCCTTGATTCCTCTGCCTCAAAGTTGGGATCTGAAAGCCATGTAGGGCTAGAAGACCCTGAGGCTGTTCTC
CCTTCTGTTCATAGTGAGACTCAAAAAGCCAAGTCCCAGAAGTTCTGAAGGGCTGTGACTAGAAGTGCCCAGGTCCTTCAGGGAGCTTTA
AGAATGACCCCACAGAACTCAAGTTTAACTAGGGGTTAGGTCCCAGATTCAGACCCAGGAGTTTATAAAAATGAGCTCTACTTCCAGTTT
TGGTTTAAATTACACATCCAGGCCAGGCACAGTGGCTCACACCTGTAATCCCAGCACTTTGGGAGGCCAGTGCGGGCGGATCATGAGGTC
AGGAGTTTGAGACCAGCCTGGCCAATGTGGTGAAACCCTGTCTCTTCCAAAAATACAAAAATTAGCTGGGCGTGGTGGCACACGCCTGTA
ATCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATCGCTTGAACCTGGGAGGCAGAGGTTGCAGTGAGCCGAGATTGCGCCACCGCACTCC
AGCCTGGGTGACAGAGTGAGACTCCGTCTCAAAAAACAAAAAGGTGACACATCCAGCTCTTTCTCCAGGTCACTGCGCTGGAGGACAGAT
GTGCCGTCTTGTCCTGCCTGTTTCACATCAGCATAGGATCAAAGGATGACAATGCTGACAGCTTCTGAAGCCGAACTCAACAGTCTCATA
GGCTCCTCACTTGTCACTTATTTTTCCCTAGCTCCCTCAACCGCACCCCATCCCTTTAGATCGTGCGTCTGTTTTAGTGACTCTGACACG
ATGCCGTCCTCACCTTCCAAATACCCAGTTATTTATTCAAGAGGGGGGAAGTGGGTAGAGGATGGGATGTTTTGGAAGCACTTTGCAAGT
TACCACTATCTGAAAATCCCCTGCTGTTGCGGGGAGAAGCTTTGAATGCACTGAAGAGAATTCCTTCTAAATGAAGGCAGGTGATAGTGT
TCTTTCTGTAAGTAAAGGGAAAGAAAAAAAACATAGTTTGCTTACCAGGTGGAGACAAGATTCAAGACATAGCAGAAGAGTGGAAGACAA
ATATTTTCCACTTAAATGAGGCTGTTTTTGACGTTCTCTGCCAAGGATTTAGAGCTTTCGTTGAACTAACATAAAAGGAGTGCGAGTCTT
AGTAGAGATGTTCCGTGTGTGCCGCCCGTGCTCTGAACTGCGTTTCCACCTGCTGTGGTGCTTGTGCAGCCTGGCAGTTCATTGTCATCT
TTAATAAACTAAGGAAATAAAATTCTGTCTTTCGTCAGCCTGCCTTGACTGTCAAGAAATGGCATGTGTCCACTGTAAAGCAGGTATATC
TGAACATTGAGAAGGTTTCTGTGTTATAATGTAAAGCAAACTGGACCACACACATCAAGGAAAGTGAGGTGGAGTGGCTGTGTCTCTAAC
TTGCCATGAGACCTCGAGCGAACCACTTCACTTCTCTGGGTTTCTGGTGCATGGTGTAACTGTCACTTAAAATGAGGTGTCTTCCTCTCC
GCAACATCTGACTTGCCTTAGATGCTTCAGTTCCCACTTCTGTGAGCAGCTAGCATCTTTCTCTTCTGCTCCTGGCCCACTGGAGCTCCA
GCTCTACGCTGCAACTCTCTCAACATTTCCCCTTAAATGTCCCCTTGTCATCTCCAACCAGTGTGTCTAAAACCAGCATAAATTCCGTAT
TTCCAAAAACCTAACCATTAGTCACCCAGGTTTGAAAATTAATTGTCTTCAACTTCCTCTGTAAGTGGCACACTGAGCTCATCACGCATC

>45722_45722_4_LMAN2-KIAA0226_LMAN2_chr5_176761285_ENST00000515209_KIAA0226_chr3_197411088_ENST00000273582_length(amino acids)=680AA_BP=303
MAAEGWIWRWGWGRRCLGRPGLLGPGPGPTTPLFLLLLLGSVTADITDGNSEHLKREHSLIKPYQGVGSSSMPLWDFQGSTMLTSQYVRL
TPDERSKEGSIWNHQPCFLKDWEMHVHFKVHGTGKKNLHGDGIALWYTRDRLVPGPVFGSKDNFHGLAIFLDTYPNDETTERVFPYISVM
VNNGSLSYDHSKDGRWTELAGCTADFRNRDHDTFLAVRYSRGRLTVMTDLEDKNEWKNCIDITGVRLPTGYYFGASAGTGDLSDNHDIIS
MKLFQLMVEHTPDEESIDWTKIEPSVNFLKSPKDADIRRNTASSSKSFVSSQSFSHCFLHSTSAEAVAMGLLKQFEGMQLPAASELEWLV
PEHDAPQKLLPIPDSLPISPDDGQHADIYKLRIRVRGNLEWAPPRPQIIFNVHPAPTRKIAVAKQNYRCAGCGIRTDPDYIKRLRYCEYL
GKYFCQCCHENAQMAIPSRVLRKWDFSKYYVSNFSKDLLIKIWNDPLFNVQDINSALYRKVKLLNQVRLLRVQLCHMKNMFKTCRLAKEL
LDSFDTVPGHLTEDLHLYSLNDLTATRKGELGPRLAELTRAGATHVERCMLCQAKGFICEFCQNEDDIIFPFELHKCRTCEECKACYHKA

--------------------------------------------------------------
>45722_45722_5_LMAN2-KIAA0226_LMAN2_chr5_176761285_ENST00000515209_KIAA0226_chr3_197411088_ENST00000296343_length(transcript)=2043nt_BP=910nt
ATGGCGGCGGAAGGCTGGATTTGGCGTTGGGGCTGGGGCCGGCGGTGCCTGGGAAGGCCTGGGCTTCTCGGCCCCGGCCCTGGCCCCACT
ACACCTCTCTTTCTTCTTTTGTTGTTGGGGTCTGTGACTGCGGATATAACTGACGGCAACAGTGAACATCTCAAGCGGGAGCATTCGCTC
ATTAAGCCCTACCAAGGGGTCGGTTCCAGCTCTATGCCCCTCTGGGACTTCCAGGGCAGCACTATGCTCACGAGCCAGTACGTACGTCTG
ACCCCTGACGAGCGCAGCAAAGAGGGCTCTATCTGGAACCACCAGCCGTGCTTCCTCAAAGACTGGGAAATGCACGTCCACTTCAAAGTC
CACGGCACAGGGAAGAAGAACCTCCATGGAGACGGCATCGCCTTGTGGTACACCCGGGACCGCCTCGTGCCAGGGCCTGTGTTTGGAAGC
AAAGATAACTTCCACGGCTTAGCCATCTTCCTGGACACCTACCCCAATGATGAGACCACTGAGCGCGTGTTCCCGTACATCTCGGTGATG
GTGAACAATGGCTCCCTGTCCTACGACCACAGCAAGGATGGGCGCTGGACCGAGCTGGCGGGCTGCACGGCTGACTTCCGCAACCGCGAT
CACGACACCTTCCTGGCTGTGCGCTACTCCCGGGGCCGTCTGACGGTGATGACCGACCTGGAGGACAAGAACGAGTGGAAGAACTGCATT
GACATCACGGGAGTGCGCCTGCCCACCGGCTACTACTTCGGGGCCTCCGCCGGCACCGGCGACCTGTCTGACAATCATGACATCATCTCC
ATGAAGCTGTTCCAGCTGATGGTGGAGCACACGCCCGACGAGGAGAGCATCGACTGGACCAAGATCGAGCCCAGCGTCAACTTCCTCAAG
TCGCCCAAAGATGCTGACATCAGAAGGAACACAGCCTCAAGCAGCAAATCCTTCGTTTCCTCCCAGTCCTTCTCCCACTGCTTCCTGCAC
TCCACGTCTGCTGAGGCGGTGGCCATGGGGCTCCTGAAGCAGTTTGAGGGGATGCAGCTTCCAGCCGCCTCGGAGCTGGAGTGGCTTGTC
CCGGAGCATGATGCCCCTCAGAAGCTCCTGCCCATTCCTGACTCACTGCCCATCTCACCGGATGACGGGCAGCACGCTGACATCTACAAG
CTGCGGATTCGTGTTCGTGGCAACTTGGAGTGGGCCCCGCCCCGGCCTCAGATAATTTTTAATGTTCATCCAGCCCCAACGAGGAAAATT
GCCGTGGCCAAGCAGAATTACCGCTGTGCAGGATGTGGCATCCGGACTGACCCTGATTACATCAAGCGACTGCGGTACTGTGAGTACCTG
GGCAAGTACTTCTGCCAGTGCTGCCACGAGAATGCCCAGATGGCCATCCCCAGCCGGGTTCTGCGCAAGTGGGACTTCAGCAAGTACTAC
GTCAGCAACTTCTCCAAGGACCTGCTCATTAAGATCTGGAATGATCCTCTCTTCAACGTGCAGGACATAAACAGTGCCCTCTATAGGAAG
GTCAAGCTGCTCAATCAAGTCCGGCTGCTGCGGGTCCAGCTGTGTCACATGAAGAACATGTTCAAGACTTGCCGACTGGCCAAGGAGCTT
CTGGATTCCTTTGACACAGTCCCAGGCCACCTGACAGAGGACCTCCACCTGTACTCACTGAATGACCTGACTGCGACCAGGAAGGGGGAG
CTGGGGCCCCGGCTTGCTGAGCTCACCAGGGCAGGGGCTACCCATGTGGAGAGATGCATGCTCTGCCAAGCCAAAGGCTTCATCTGTGAG
TTCTGTCAGAATGAGGATGACATCATCTTTCCCTTTGAGCTCCATAAGTGCCGGACCTGTGAAGAGTGTAAAGCGTGTTACCATAAAGCC
TGCTTCAAGTCTGGAAGCTGTCCGCGCTGCGAGCGGCTGCAGGCCCGGCGGGAGGCACTGGCCAGGCAGAGCCTGGAGTCTTACCTGTCA

>45722_45722_5_LMAN2-KIAA0226_LMAN2_chr5_176761285_ENST00000515209_KIAA0226_chr3_197411088_ENST00000296343_length(amino acids)=680AA_BP=303
MAAEGWIWRWGWGRRCLGRPGLLGPGPGPTTPLFLLLLLGSVTADITDGNSEHLKREHSLIKPYQGVGSSSMPLWDFQGSTMLTSQYVRL
TPDERSKEGSIWNHQPCFLKDWEMHVHFKVHGTGKKNLHGDGIALWYTRDRLVPGPVFGSKDNFHGLAIFLDTYPNDETTERVFPYISVM
VNNGSLSYDHSKDGRWTELAGCTADFRNRDHDTFLAVRYSRGRLTVMTDLEDKNEWKNCIDITGVRLPTGYYFGASAGTGDLSDNHDIIS
MKLFQLMVEHTPDEESIDWTKIEPSVNFLKSPKDADIRRNTASSSKSFVSSQSFSHCFLHSTSAEAVAMGLLKQFEGMQLPAASELEWLV
PEHDAPQKLLPIPDSLPISPDDGQHADIYKLRIRVRGNLEWAPPRPQIIFNVHPAPTRKIAVAKQNYRCAGCGIRTDPDYIKRLRYCEYL
GKYFCQCCHENAQMAIPSRVLRKWDFSKYYVSNFSKDLLIKIWNDPLFNVQDINSALYRKVKLLNQVRLLRVQLCHMKNMFKTCRLAKEL
LDSFDTVPGHLTEDLHLYSLNDLTATRKGELGPRLAELTRAGATHVERCMLCQAKGFICEFCQNEDDIIFPFELHKCRTCEECKACYHKA

--------------------------------------------------------------
>45722_45722_6_LMAN2-KIAA0226_LMAN2_chr5_176761285_ENST00000515209_KIAA0226_chr3_197411088_ENST00000389665_length(transcript)=1815nt_BP=910nt
ATGGCGGCGGAAGGCTGGATTTGGCGTTGGGGCTGGGGCCGGCGGTGCCTGGGAAGGCCTGGGCTTCTCGGCCCCGGCCCTGGCCCCACT
ACACCTCTCTTTCTTCTTTTGTTGTTGGGGTCTGTGACTGCGGATATAACTGACGGCAACAGTGAACATCTCAAGCGGGAGCATTCGCTC
ATTAAGCCCTACCAAGGGGTCGGTTCCAGCTCTATGCCCCTCTGGGACTTCCAGGGCAGCACTATGCTCACGAGCCAGTACGTACGTCTG
ACCCCTGACGAGCGCAGCAAAGAGGGCTCTATCTGGAACCACCAGCCGTGCTTCCTCAAAGACTGGGAAATGCACGTCCACTTCAAAGTC
CACGGCACAGGGAAGAAGAACCTCCATGGAGACGGCATCGCCTTGTGGTACACCCGGGACCGCCTCGTGCCAGGGCCTGTGTTTGGAAGC
AAAGATAACTTCCACGGCTTAGCCATCTTCCTGGACACCTACCCCAATGATGAGACCACTGAGCGCGTGTTCCCGTACATCTCGGTGATG
GTGAACAATGGCTCCCTGTCCTACGACCACAGCAAGGATGGGCGCTGGACCGAGCTGGCGGGCTGCACGGCTGACTTCCGCAACCGCGAT
CACGACACCTTCCTGGCTGTGCGCTACTCCCGGGGCCGTCTGACGGTGATGACCGACCTGGAGGACAAGAACGAGTGGAAGAACTGCATT
GACATCACGGGAGTGCGCCTGCCCACCGGCTACTACTTCGGGGCCTCCGCCGGCACCGGCGACCTGTCTGACAATCATGACATCATCTCC
ATGAAGCTGTTCCAGCTGATGGTGGAGCACACGCCCGACGAGGAGAGCATCGACTGGACCAAGATCGAGCCCAGCGTCAACTTCCTCAAG
TCGCCCAAAGATGCTGACATCAGAAGGAACACAGCCTCAAGCAGCAAATCCTTCGTTTCCTCCCAGTCCTTCTCCCACTGCTTCCTGCAC
TCCACGTCTGCTGAGGCGGTGGCCATGGGGCTCCTGAAGCAGTTTGAGGGGATGCAGCTTCCAGCCGCCTCGGAGCTGGAGTGGCTTGTC
CCGGAGCATGATGCCCCTCAGAAGCTCCTGCCCATTCCTGACTCACTGCCCATCTCACCGGATGACGGGCAGCACGCTGACATCTACAAG
CTGCGGATTCGTGTTCGTGGCAACTTGGAGTGGGCCCCGCCCCGGCCTCAGATAATTTTTAATGTTCATCCAGCCCCAACGAGGAAAATT
GCCGTGGCCAAGCAGAATTACCGCTGTGCAGGATGTGGCATCCGGACTGACCCTGATTACATCAAGCGACTGCGGTACTGTGAGTACCTG
GGCAAGTACTTCTGCCAGTGCTGCCACGAGAATGCCCAGATGGCCATCCCCAGCCGGGTTCTGCGCAAGTGGGACTTCAGCAAGTACTAC
GTCAGCAACTTCTCCAAGGACCTGCTCATTAAGATCTGGAATGATCCTCTCTTCAACGTGCAGGACATAAACAGTGCCCTCTATAGGAAG
GTCAAGCTGCTCAATCAAGTCCGGCTGCTGCGGGTCCAGCTGTGTCACATGAAGAACATGTTCAAGACTTGCCGACTGGCCAAGGAGCTT
CTGGATTCCTTTGACACAGTCCCAGGCCACCTGACAGAGGACCTCCACCTGTACTCACTGAATGACCTGACTGCGACCAGGAAGGGGGAG
CTGGGGCCCCGGCTTGCTGAGCTCACCAGGGCAGGGGCTACCCATGTGGAGAGATGCATGGTGAGAAAGTCTCACTGTAGCATGCAGCTG

>45722_45722_6_LMAN2-KIAA0226_LMAN2_chr5_176761285_ENST00000515209_KIAA0226_chr3_197411088_ENST00000389665_length(amino acids)=604AA_BP=303
MAAEGWIWRWGWGRRCLGRPGLLGPGPGPTTPLFLLLLLGSVTADITDGNSEHLKREHSLIKPYQGVGSSSMPLWDFQGSTMLTSQYVRL
TPDERSKEGSIWNHQPCFLKDWEMHVHFKVHGTGKKNLHGDGIALWYTRDRLVPGPVFGSKDNFHGLAIFLDTYPNDETTERVFPYISVM
VNNGSLSYDHSKDGRWTELAGCTADFRNRDHDTFLAVRYSRGRLTVMTDLEDKNEWKNCIDITGVRLPTGYYFGASAGTGDLSDNHDIIS
MKLFQLMVEHTPDEESIDWTKIEPSVNFLKSPKDADIRRNTASSSKSFVSSQSFSHCFLHSTSAEAVAMGLLKQFEGMQLPAASELEWLV
PEHDAPQKLLPIPDSLPISPDDGQHADIYKLRIRVRGNLEWAPPRPQIIFNVHPAPTRKIAVAKQNYRCAGCGIRTDPDYIKRLRYCEYL
GKYFCQCCHENAQMAIPSRVLRKWDFSKYYVSNFSKDLLIKIWNDPLFNVQDINSALYRKVKLLNQVRLLRVQLCHMKNMFKTCRLAKEL

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Fusion Gene PPI Analysis for LMAN2-KIAA0226


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneKIAA0226chr5:176761285chr3:197411088ENST000002735821121672_760550.3333333333334928.0CARD9
TgeneKIAA0226chr5:176761285chr3:197411088ENST000002963431020672_760595.3333333333334973.0CARD9
TgeneKIAA0226chr5:176761285chr3:197411088ENST000003896651119672_760620.3333333333334922.0CARD9
TgeneKIAA0226chr5:176761285chr3:197411088ENST000002735821121721_972550.3333333333334928.0Rab7
TgeneKIAA0226chr5:176761285chr3:197411088ENST000002963431020721_972595.3333333333334973.0Rab7
TgeneKIAA0226chr5:176761285chr3:197411088ENST000003896651119721_972620.3333333333334922.0Rab7


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneKIAA0226chr5:176761285chr3:197411088ENST000002735821121505_557550.3333333333334928.0BECN1
TgeneKIAA0226chr5:176761285chr3:197411088ENST000002963431020505_557595.3333333333334973.0BECN1
TgeneKIAA0226chr5:176761285chr3:197411088ENST000003896651119505_557620.3333333333334922.0BECN1
TgeneKIAA0226chr5:176761285chr3:197411088ENST00000273582112149_180550.3333333333334928.0PIK3C3
TgeneKIAA0226chr5:176761285chr3:197411088ENST00000296343102049_180595.3333333333334973.0PIK3C3
TgeneKIAA0226chr5:176761285chr3:197411088ENST00000389665111949_180620.3333333333334922.0PIK3C3
TgeneKIAA0226chr5:176761285chr3:197411088ENST000002735821121300_600550.3333333333334928.0UVRAG
TgeneKIAA0226chr5:176761285chr3:197411088ENST000002963431020300_600595.3333333333334973.0UVRAG
TgeneKIAA0226chr5:176761285chr3:197411088ENST000003896651119300_600620.3333333333334922.0UVRAG


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for LMAN2-KIAA0226


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for LMAN2-KIAA0226


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource