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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:LMAN2-NOP16 (FusionGDB2 ID:45728)

Fusion Gene Summary for LMAN2-NOP16

check button Fusion gene summary
Fusion gene informationFusion gene name: LMAN2-NOP16
Fusion gene ID: 45728
HgeneTgene
Gene symbol

LMAN2

NOP16

Gene ID

10960

51491

Gene namelectin, mannose binding 2NOP16 nucleolar protein
SynonymsC5orf8|GP36B|VIP36HSPC111|HSPC185
Cytomap

5q35.3

5q35.2

Type of geneprotein-codingprotein-coding
Descriptionvesicular integral-membrane protein VIP36epididymis secretory sperm binding proteinglycoprotein GP36bvesicular integral protein of 36 kDavesicular integral-membrane protein 36nucleolar protein 16HBV pre-S2 trans-regulated protein 3NOP16 nucleolar protein homologhypothetical protein HSPC111nucleolar protein 16 homolog
Modification date2020031320200313
UniProtAcc

Q12907

Q9Y3C1

Ensembl transtripts involved in fusion geneENST00000303127, ENST00000515209, 
ENST00000506310, 
ENST00000507413, 
ENST00000509257, ENST00000389158, 
ENST00000510123, 
Fusion gene scores* DoF score10 X 6 X 11=6605 X 8 X 3=120
# samples 116
** MAII scorelog2(11/660*10)=-2.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/120*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: LMAN2 [Title/Abstract] AND NOP16 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointLMAN2(176778174)-NOP16(175813910), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across LMAN2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across NOP16 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4CESCTCGA-C5-A7X3-01ALMAN2chr5

176778174

-NOP16chr5

175813910

-


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Fusion Gene ORF analysis for LMAN2-NOP16

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000303127ENST00000507413LMAN2chr5

176778174

-NOP16chr5

175813910

-
5CDS-intronENST00000303127ENST00000509257LMAN2chr5

176778174

-NOP16chr5

175813910

-
5CDS-intronENST00000515209ENST00000507413LMAN2chr5

176778174

-NOP16chr5

175813910

-
5CDS-intronENST00000515209ENST00000509257LMAN2chr5

176778174

-NOP16chr5

175813910

-
5UTR-3CDSENST00000506310ENST00000389158LMAN2chr5

176778174

-NOP16chr5

175813910

-
5UTR-3CDSENST00000506310ENST00000510123LMAN2chr5

176778174

-NOP16chr5

175813910

-
5UTR-intronENST00000506310ENST00000507413LMAN2chr5

176778174

-NOP16chr5

175813910

-
5UTR-intronENST00000506310ENST00000509257LMAN2chr5

176778174

-NOP16chr5

175813910

-
In-frameENST00000303127ENST00000389158LMAN2chr5

176778174

-NOP16chr5

175813910

-
In-frameENST00000303127ENST00000510123LMAN2chr5

176778174

-NOP16chr5

175813910

-
In-frameENST00000515209ENST00000389158LMAN2chr5

176778174

-NOP16chr5

175813910

-
In-frameENST00000515209ENST00000510123LMAN2chr5

176778174

-NOP16chr5

175813910

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000303127LMAN2chr5176778174-ENST00000510123NOP16chr5175813910-10335202051014269
ENST00000303127LMAN2chr5176778174-ENST00000389158NOP16chr5175813910-112452096310317
ENST00000515209LMAN2chr5176778174-ENST00000510123NOP16chr5175813910-8283150809269
ENST00000515209LMAN2chr5176778174-ENST00000389158NOP16chr5175813910-9193157580253

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000303127ENST00000510123LMAN2chr5176778174-NOP16chr5175813910-0.233749270.7662507
ENST00000303127ENST00000389158LMAN2chr5176778174-NOP16chr5175813910-0.010258460.98974156
ENST00000515209ENST00000510123LMAN2chr5176778174-NOP16chr5175813910-0.233245040.7667549
ENST00000515209ENST00000389158LMAN2chr5176778174-NOP16chr5175813910-0.006929540.9930704

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Fusion Genomic Features for LMAN2-NOP16


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for LMAN2-NOP16


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:176778174/chr5:175813910)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LMAN2

Q12907

NOP16

Q9Y3C1

FUNCTION: Plays a role as an intracellular lectin in the early secretory pathway. Interacts with N-acetyl-D-galactosamine and high-mannose type glycans and may also bind to O-linked glycans. Involved in the transport and sorting of glycoproteins carrying high mannose-type glycans (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLMAN2chr5:176778174chr5:175813910ENST00000303127-2852_276105357.0DomainL-type lectin-like
HgeneLMAN2chr5:176778174chr5:175813910ENST00000303127-28164_166105357.0RegionCarbohydrate binding
HgeneLMAN2chr5:176778174chr5:175813910ENST00000303127-28260_262105357.0RegionCarbohydrate binding
HgeneLMAN2chr5:176778174chr5:175813910ENST00000303127-28346_356105357.0Topological domainCytoplasmic
HgeneLMAN2chr5:176778174chr5:175813910ENST00000303127-2845_322105357.0Topological domainLumenal
HgeneLMAN2chr5:176778174chr5:175813910ENST00000303127-28323_345105357.0TransmembraneHelical


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Fusion Gene Sequence for LMAN2-NOP16


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>45728_45728_1_LMAN2-NOP16_LMAN2_chr5_176778174_ENST00000303127_NOP16_chr5_175813910_ENST00000389158_length(transcript)=1124nt_BP=520nt
CTTGGAGCCTCTAAGGAGATGAAACTGCACTCAACCAGGATGAGAGGCTGCCCGGCCAATGCAGCTGCCGCCCCGTCTGCTGCGGAGGCT
TTGCTTTTTGACTCCCTGGCGACAGTAAAGTTGAAGAGCTTCCGGCCGGAGGCCAATAGATGGGACCCCCGGAAGGCGGAAGTTCTAGGG
CGGAAGTGGCCGAGAGGAGAGGAGAATGGCGGCGGAAGGCTGGATTTGGCGTTGGGGCTGGGGCCGGCGGTGCCTGGGAAGGCCTGGGCT
TCTCGGCCCCGGCCCTGGCCCCACTACACCTCTCTTTCTTCTTTTGTTGTTGGGGTCTGTGACTGCGGATATAACTGACGGCAACAGTGA
ACATCTCAAGCGGGAGCATTCGCTCATTAAGCCCTACCAAGGGGTCGGTTCCAGCTCTATGCCCCTCTGGGACTTCCAGGGCAGCACTAT
GCTCACGAGCCAGTACGTACGTCTGACCCCTGACGAGCGCAGCAAAGAGGGCTCTATCTGGAACCACCAGGTGAAGGCCATGGAGGTGGA
CATAGAGGAGAGGCCTAAAGAGCTTGTACGGAAGCCCTATGTGCTGAATGACCTGGAGGCAGAAGCCAGCCTTCCAGAAAAGAAAGGAAA
TACTCTGTCTCGGGACCTCATTGACTATGTACGCTACATGGTAGAGAACCACGGGGAGGACTATAAGGCCATGGCCCGTGATGAGAAGAA
TTACTATCAAGATACCCCAAAACAGATTCGGAGTAAGATCAACGTCTATAAACGCTTTTACCCAGCAGAGTGGCAAGACTTCCTCGATTC
TTTGCAGAAGAGGAAGATGGAGGTGGAGTGACTGGTTTACATCACAGCTGCCCCAGGCTGAGGCGTCCCCCGGACCAGTGAAGCTGGAGC
CAGGGTGTAAGGCAAGGAGGTGCTGTGTGGCTCCAGAGGAGCTGGCCAGGTCCCATGGAATCAGAAGGTTACACACACGTGCACACTCCC
CGCTCTGGGGAAGGAACTGTTCTCAGAGGCTCCAATTTATATTCATCTGGGGGTTCACGGAAAAGCCAGAACCTGCTGTTTTCAGGGTGG

>45728_45728_1_LMAN2-NOP16_LMAN2_chr5_176778174_ENST00000303127_NOP16_chr5_175813910_ENST00000389158_length(amino acids)=317AA_BP=125
MIPWDLASSSGATQHLLALHPGSSFTGPGDASAWGSCDVNQSLHLHLPLLQRIEEVLPLCWVKAFIDVDLTPNLFWGILIVILLITGHGL
IVLPVVLYHVAYIVNEVPRQSISFLFWKAGFCLQVIQHIGLPYKLFRPLLYVHLHGLHLVVPDRALFAALVRGQTYVLAREHSAALEVPE
GHRAGTDPLVGLNERMLPLEMFTVAVSYIRSHRPQQQKKKERCSGARAGAEKPRPSQAPPAPAPTPNPAFRRHSPLLSATSALELPPSGG

--------------------------------------------------------------
>45728_45728_2_LMAN2-NOP16_LMAN2_chr5_176778174_ENST00000303127_NOP16_chr5_175813910_ENST00000510123_length(transcript)=1033nt_BP=520nt
CTTGGAGCCTCTAAGGAGATGAAACTGCACTCAACCAGGATGAGAGGCTGCCCGGCCAATGCAGCTGCCGCCCCGTCTGCTGCGGAGGCT
TTGCTTTTTGACTCCCTGGCGACAGTAAAGTTGAAGAGCTTCCGGCCGGAGGCCAATAGATGGGACCCCCGGAAGGCGGAAGTTCTAGGG
CGGAAGTGGCCGAGAGGAGAGGAGAATGGCGGCGGAAGGCTGGATTTGGCGTTGGGGCTGGGGCCGGCGGTGCCTGGGAAGGCCTGGGCT
TCTCGGCCCCGGCCCTGGCCCCACTACACCTCTCTTTCTTCTTTTGTTGTTGGGGTCTGTGACTGCGGATATAACTGACGGCAACAGTGA
ACATCTCAAGCGGGAGCATTCGCTCATTAAGCCCTACCAAGGGGTCGGTTCCAGCTCTATGCCCCTCTGGGACTTCCAGGGCAGCACTAT
GCTCACGAGCCAGTACGTACGTCTGACCCCTGACGAGCGCAGCAAAGAGGGCTCTATCTGGAACCACCAGGTGAAGGCCATGGAGGTGGA
CATAGAGGAGAGGCCTAAAGAGCTTGTACGGAAGCCCTATGTGCTGAATGACCTGGAGGCAGAAGCCAGCCTTCCAGAAAAGAAAGGAAA
TACTCTGTCTCGGGACCTCATTGACTATGTACGCTACATGGTAGAGAACCACGGGGAGGACTATAAGAGTGGCAAGACTTCCTCGATTCT
TTGCAGAAGAGGAAGATGGAGGTGGAGTGACTGGTTTACATCACAGCTGCCCCAGGCTGAGGCGTCCCCCGGACCAGTGAAGCTGGAGCC
AGGGTGTAAGGCAAGGAGGTGCTGTGTGGCTCCAGAGGAGCTGGCCAGGTCCCATGGAATCAGAAGGTTACACACACGTGCACACTCCCC
GCTCTGGGGAAGGAACTGTTCTCAGAGGCTCCAATTTATATTCATCTGGGGGTTCACGGAAAAGCCAGAACCTGCTGTTTTCAGGGTGGG

>45728_45728_2_LMAN2-NOP16_LMAN2_chr5_176778174_ENST00000303127_NOP16_chr5_175813910_ENST00000510123_length(amino acids)=269AA_BP=0
MAAEGWIWRWGWGRRCLGRPGLLGPGPGPTTPLFLLLLLGSVTADITDGNSEHLKREHSLIKPYQGVGSSSMPLWDFQGSTMLTSQYVRL
TPDERSKEGSIWNHQVKAMEVDIEERPKELVRKPYVLNDLEAEASLPEKKGNTLSRDLIDYVRYMVENHGEDYKSGKTSSILCRRGRWRW

--------------------------------------------------------------
>45728_45728_3_LMAN2-NOP16_LMAN2_chr5_176778174_ENST00000515209_NOP16_chr5_175813910_ENST00000389158_length(transcript)=919nt_BP=315nt
ATGGCGGCGGAAGGCTGGATTTGGCGTTGGGGCTGGGGCCGGCGGTGCCTGGGAAGGCCTGGGCTTCTCGGCCCCGGCCCTGGCCCCACT
ACACCTCTCTTTCTTCTTTTGTTGTTGGGGTCTGTGACTGCGGATATAACTGACGGCAACAGTGAACATCTCAAGCGGGAGCATTCGCTC
ATTAAGCCCTACCAAGGGGTCGGTTCCAGCTCTATGCCCCTCTGGGACTTCCAGGGCAGCACTATGCTCACGAGCCAGTACGTACGTCTG
ACCCCTGACGAGCGCAGCAAAGAGGGCTCTATCTGGAACCACCAGGTGAAGGCCATGGAGGTGGACATAGAGGAGAGGCCTAAAGAGCTT
GTACGGAAGCCCTATGTGCTGAATGACCTGGAGGCAGAAGCCAGCCTTCCAGAAAAGAAAGGAAATACTCTGTCTCGGGACCTCATTGAC
TATGTACGCTACATGGTAGAGAACCACGGGGAGGACTATAAGGCCATGGCCCGTGATGAGAAGAATTACTATCAAGATACCCCAAAACAG
ATTCGGAGTAAGATCAACGTCTATAAACGCTTTTACCCAGCAGAGTGGCAAGACTTCCTCGATTCTTTGCAGAAGAGGAAGATGGAGGTG
GAGTGACTGGTTTACATCACAGCTGCCCCAGGCTGAGGCGTCCCCCGGACCAGTGAAGCTGGAGCCAGGGTGTAAGGCAAGGAGGTGCTG
TGTGGCTCCAGAGGAGCTGGCCAGGTCCCATGGAATCAGAAGGTTACACACACGTGCACACTCCCCGCTCTGGGGAAGGAACTGTTCTCA
GAGGCTCCAATTTATATTCATCTGGGGGTTCACGGAAAAGCCAGAACCTGCTGTTTTCAGGGTGGGTGATGTAAATATAGTGTGTACATA

>45728_45728_3_LMAN2-NOP16_LMAN2_chr5_176778174_ENST00000515209_NOP16_chr5_175813910_ENST00000389158_length(amino acids)=253AA_BP=125
MIPWDLASSSGATQHLLALHPGSSFTGPGDASAWGSCDVNQSLHLHLPLLQRIEEVLPLCWVKAFIDVDLTPNLFWGILIVILLITGHGL
IVLPVVLYHVAYIVNEVPRQSISFLFWKAGFCLQVIQHIGLPYKLFRPLLYVHLHGLHLVVPDRALFAALVRGQTYVLAREHSAALEVPE

--------------------------------------------------------------
>45728_45728_4_LMAN2-NOP16_LMAN2_chr5_176778174_ENST00000515209_NOP16_chr5_175813910_ENST00000510123_length(transcript)=828nt_BP=315nt
ATGGCGGCGGAAGGCTGGATTTGGCGTTGGGGCTGGGGCCGGCGGTGCCTGGGAAGGCCTGGGCTTCTCGGCCCCGGCCCTGGCCCCACT
ACACCTCTCTTTCTTCTTTTGTTGTTGGGGTCTGTGACTGCGGATATAACTGACGGCAACAGTGAACATCTCAAGCGGGAGCATTCGCTC
ATTAAGCCCTACCAAGGGGTCGGTTCCAGCTCTATGCCCCTCTGGGACTTCCAGGGCAGCACTATGCTCACGAGCCAGTACGTACGTCTG
ACCCCTGACGAGCGCAGCAAAGAGGGCTCTATCTGGAACCACCAGGTGAAGGCCATGGAGGTGGACATAGAGGAGAGGCCTAAAGAGCTT
GTACGGAAGCCCTATGTGCTGAATGACCTGGAGGCAGAAGCCAGCCTTCCAGAAAAGAAAGGAAATACTCTGTCTCGGGACCTCATTGAC
TATGTACGCTACATGGTAGAGAACCACGGGGAGGACTATAAGAGTGGCAAGACTTCCTCGATTCTTTGCAGAAGAGGAAGATGGAGGTGG
AGTGACTGGTTTACATCACAGCTGCCCCAGGCTGAGGCGTCCCCCGGACCAGTGAAGCTGGAGCCAGGGTGTAAGGCAAGGAGGTGCTGT
GTGGCTCCAGAGGAGCTGGCCAGGTCCCATGGAATCAGAAGGTTACACACACGTGCACACTCCCCGCTCTGGGGAAGGAACTGTTCTCAG
AGGCTCCAATTTATATTCATCTGGGGGTTCACGGAAAAGCCAGAACCTGCTGTTTTCAGGGTGGGTGATGTAAATATAGTGTGTACATAA

>45728_45728_4_LMAN2-NOP16_LMAN2_chr5_176778174_ENST00000515209_NOP16_chr5_175813910_ENST00000510123_length(amino acids)=269AA_BP=0
MAAEGWIWRWGWGRRCLGRPGLLGPGPGPTTPLFLLLLLGSVTADITDGNSEHLKREHSLIKPYQGVGSSSMPLWDFQGSTMLTSQYVRL
TPDERSKEGSIWNHQVKAMEVDIEERPKELVRKPYVLNDLEAEASLPEKKGNTLSRDLIDYVRYMVENHGEDYKSGKTSSILCRRGRWRW

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Fusion Gene PPI Analysis for LMAN2-NOP16


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for LMAN2-NOP16


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for LMAN2-NOP16


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource