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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:LMBR1L-KCNK6 (FusionGDB2 ID:45737)

Fusion Gene Summary for LMBR1L-KCNK6

check button Fusion gene summary
Fusion gene informationFusion gene name: LMBR1L-KCNK6
Fusion gene ID: 45737
HgeneTgene
Gene symbol

LMBR1L

KCNK6

Gene ID

55716

9424

Gene namelimb development membrane protein 1 likepotassium two pore domain channel subfamily K member 6
SynonymsLIMRK2p6.1|KCNK8|TOSS|TWIK-2|TWIK2
Cytomap

12q13.12

19q13.2

Type of geneprotein-codingprotein-coding
Descriptionprotein LMBR1Llimb region 1 homolog-likelimb region 1 protein homolog-likelimb region 1-like protein -likelipocalin-1 interacting membrane receptorlipocalin-interacting membrane receptorpotassium channel subfamily K member 6K2P6.1 potassium channelTWIK-originated similarity sequenceTWIK-originated sodium similarity sequenceinward rectifying potassium channel protein TWIK-2potassium channel, two pore domain subfamily K, member 6
Modification date2020031320200313
UniProtAcc

Q6UX01

Q9Y257

Ensembl transtripts involved in fusion geneENST00000267102, ENST00000395141, 
ENST00000547382, ENST00000553204, 
ENST00000588137, ENST00000263372, 
Fusion gene scores* DoF score6 X 6 X 4=1443 X 3 X 2=18
# samples 53
** MAII scorelog2(5/144*10)=-1.52606881166759
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: LMBR1L [Title/Abstract] AND KCNK6 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointLMBR1L(49504267)-KCNK6(38817233), # samples:3
Anticipated loss of major functional domain due to fusion event.LMBR1L-KCNK6 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneLMBR1L

GO:0007165

signal transduction

11287427


check buttonFusion gene breakpoints across LMBR1L (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across KCNK6 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-CU-A0YN-01ALMBR1Lchr12

49499707

-KCNK6chr19

38817233

+
ChimerDB4BLCATCGA-CU-A0YN-01ALMBR1Lchr12

49500744

-KCNK6chr19

38817233

+
ChimerDB4BLCATCGA-CU-A0YN-01ALMBR1Lchr12

49504267

-KCNK6chr19

38817233

+


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Fusion Gene ORF analysis for LMBR1L-KCNK6

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000267102ENST00000588137LMBR1Lchr12

49499707

-KCNK6chr19

38817233

+
5CDS-intronENST00000267102ENST00000588137LMBR1Lchr12

49500744

-KCNK6chr19

38817233

+
5CDS-intronENST00000267102ENST00000588137LMBR1Lchr12

49504267

-KCNK6chr19

38817233

+
5CDS-intronENST00000395141ENST00000588137LMBR1Lchr12

49499707

-KCNK6chr19

38817233

+
5CDS-intronENST00000547382ENST00000588137LMBR1Lchr12

49499707

-KCNK6chr19

38817233

+
5CDS-intronENST00000547382ENST00000588137LMBR1Lchr12

49500744

-KCNK6chr19

38817233

+
5CDS-intronENST00000547382ENST00000588137LMBR1Lchr12

49504267

-KCNK6chr19

38817233

+
5UTR-3CDSENST00000553204ENST00000263372LMBR1Lchr12

49499707

-KCNK6chr19

38817233

+
5UTR-3CDSENST00000553204ENST00000263372LMBR1Lchr12

49500744

-KCNK6chr19

38817233

+
5UTR-3CDSENST00000553204ENST00000263372LMBR1Lchr12

49504267

-KCNK6chr19

38817233

+
5UTR-intronENST00000553204ENST00000588137LMBR1Lchr12

49499707

-KCNK6chr19

38817233

+
5UTR-intronENST00000553204ENST00000588137LMBR1Lchr12

49500744

-KCNK6chr19

38817233

+
5UTR-intronENST00000553204ENST00000588137LMBR1Lchr12

49504267

-KCNK6chr19

38817233

+
Frame-shiftENST00000267102ENST00000263372LMBR1Lchr12

49499707

-KCNK6chr19

38817233

+
Frame-shiftENST00000267102ENST00000263372LMBR1Lchr12

49504267

-KCNK6chr19

38817233

+
Frame-shiftENST00000395141ENST00000263372LMBR1Lchr12

49499707

-KCNK6chr19

38817233

+
Frame-shiftENST00000547382ENST00000263372LMBR1Lchr12

49499707

-KCNK6chr19

38817233

+
Frame-shiftENST00000547382ENST00000263372LMBR1Lchr12

49504267

-KCNK6chr19

38817233

+
In-frameENST00000267102ENST00000263372LMBR1Lchr12

49500744

-KCNK6chr19

38817233

+
In-frameENST00000547382ENST00000263372LMBR1Lchr12

49500744

-KCNK6chr19

38817233

+
intron-3CDSENST00000395141ENST00000263372LMBR1Lchr12

49500744

-KCNK6chr19

38817233

+
intron-3CDSENST00000395141ENST00000263372LMBR1Lchr12

49504267

-KCNK6chr19

38817233

+
intron-intronENST00000395141ENST00000588137LMBR1Lchr12

49500744

-KCNK6chr19

38817233

+
intron-intronENST00000395141ENST00000588137LMBR1Lchr12

49504267

-KCNK6chr19

38817233

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000267102LMBR1Lchr1249500744-ENST00000263372KCNK6chr1938817233+27375001901119309
ENST00000547382LMBR1Lchr1249500744-ENST00000263372KCNK6chr1938817233+26894521421071309

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000267102ENST00000263372LMBR1Lchr1249500744-KCNK6chr1938817233+0.039950880.96004915
ENST00000547382ENST00000263372LMBR1Lchr1249500744-KCNK6chr1938817233+0.0441080630.95589197

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Fusion Genomic Features for LMBR1L-KCNK6


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
LMBR1Lchr1249500743-KCNK6chr1938817232+3.29E-050.9999671
LMBR1Lchr1249499706-KCNK6chr1938817232+5.98E-070.9999994
LMBR1Lchr1249504266-KCNK6chr1938817232+2.08E-091
LMBR1Lchr1249500743-KCNK6chr1938817232+3.29E-050.9999671
LMBR1Lchr1249499706-KCNK6chr1938817232+5.98E-070.9999994
LMBR1Lchr1249504266-KCNK6chr1938817232+2.08E-091

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for LMBR1L-KCNK6


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:49504267/chr19:38817233)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LMBR1L

Q6UX01

KCNK6

Q9Y257

FUNCTION: Plays an essential role in lymphocyte development by negatively regulating the canonical Wnt signaling pathway (By similarity). In association with UBAC2 and E3 ubiquitin-protein ligase AMFR, promotes the ubiquitin-mediated degradation of CTNNB1 and Wnt receptors FZD6 and LRP6 (By similarity). LMBR1L stabilizes the beta-catenin destruction complex that is required for regulating CTNNB1 levels (By similarity). Acts as a LCN1 receptor and can mediate its endocytosis (PubMed:11287427, PubMed:12591932, PubMed:23964685). {ECO:0000250|UniProtKB:Q9D1E5, ECO:0000269|PubMed:11287427, ECO:0000269|PubMed:12591932, ECO:0000269|PubMed:23964685}.FUNCTION: Exhibits outward rectification in a physiological K(+) gradient and mild inward rectification in symmetrical K(+) conditions.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLMBR1Lchr12:49500744chr19:38817233ENST00000267102-2171_2152490.0Topological domainExtracellular
HgeneLMBR1Lchr12:49500744chr19:38817233ENST00000547382-2171_2152470.0Topological domainExtracellular
HgeneLMBR1Lchr12:49500744chr19:38817233ENST00000267102-21722_4252490.0TransmembraneHelical
HgeneLMBR1Lchr12:49500744chr19:38817233ENST00000547382-21722_4252470.0TransmembraneHelical
TgeneKCNK6chr12:49500744chr19:38817233ENST0000026337203199_223107314.0IntramembranePore-forming%3B Name%3DPore-forming 2
TgeneKCNK6chr12:49500744chr19:38817233ENST0000026337203142_172107314.0Topological domainCytoplasmic
TgeneKCNK6chr12:49500744chr19:38817233ENST0000026337203257_313107314.0Topological domainCytoplasmic
TgeneKCNK6chr12:49500744chr19:38817233ENST0000026337203121_141107314.0TransmembraneHelical
TgeneKCNK6chr12:49500744chr19:38817233ENST0000026337203173_193107314.0TransmembraneHelical
TgeneKCNK6chr12:49500744chr19:38817233ENST0000026337203236_256107314.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLMBR1Lchr12:49500744chr19:38817233ENST00000267102-2171_7652490.0RegionLCN1-binding
HgeneLMBR1Lchr12:49500744chr19:38817233ENST00000395141-1161_760485.0RegionLCN1-binding
HgeneLMBR1Lchr12:49500744chr19:38817233ENST00000547382-2171_7652470.0RegionLCN1-binding
HgeneLMBR1Lchr12:49500744chr19:38817233ENST00000267102-217136_15452490.0Topological domainCytoplasmic
HgeneLMBR1Lchr12:49500744chr19:38817233ENST00000267102-217176_19652490.0Topological domainExtracellular
HgeneLMBR1Lchr12:49500744chr19:38817233ENST00000267102-217218_30552490.0Topological domainCytoplasmic
HgeneLMBR1Lchr12:49500744chr19:38817233ENST00000267102-217327_35052490.0Topological domainExtracellular
HgeneLMBR1Lchr12:49500744chr19:38817233ENST00000267102-217372_38852490.0Topological domainCytoplasmic
HgeneLMBR1Lchr12:49500744chr19:38817233ENST00000267102-217410_43152490.0Topological domainExtracellular
HgeneLMBR1Lchr12:49500744chr19:38817233ENST00000267102-21743_6652490.0Topological domainCytoplasmic
HgeneLMBR1Lchr12:49500744chr19:38817233ENST00000267102-217453_48952490.0Topological domainCytoplasmic
HgeneLMBR1Lchr12:49500744chr19:38817233ENST00000267102-21788_11452490.0Topological domainExtracellular
HgeneLMBR1Lchr12:49500744chr19:38817233ENST00000395141-116136_1540485.0Topological domainCytoplasmic
HgeneLMBR1Lchr12:49500744chr19:38817233ENST00000395141-116176_1960485.0Topological domainExtracellular
HgeneLMBR1Lchr12:49500744chr19:38817233ENST00000395141-1161_210485.0Topological domainExtracellular
HgeneLMBR1Lchr12:49500744chr19:38817233ENST00000395141-116218_3050485.0Topological domainCytoplasmic
HgeneLMBR1Lchr12:49500744chr19:38817233ENST00000395141-116327_3500485.0Topological domainExtracellular
HgeneLMBR1Lchr12:49500744chr19:38817233ENST00000395141-116372_3880485.0Topological domainCytoplasmic
HgeneLMBR1Lchr12:49500744chr19:38817233ENST00000395141-116410_4310485.0Topological domainExtracellular
HgeneLMBR1Lchr12:49500744chr19:38817233ENST00000395141-11643_660485.0Topological domainCytoplasmic
HgeneLMBR1Lchr12:49500744chr19:38817233ENST00000395141-116453_4890485.0Topological domainCytoplasmic
HgeneLMBR1Lchr12:49500744chr19:38817233ENST00000395141-11688_1140485.0Topological domainExtracellular
HgeneLMBR1Lchr12:49500744chr19:38817233ENST00000547382-217136_15452470.0Topological domainCytoplasmic
HgeneLMBR1Lchr12:49500744chr19:38817233ENST00000547382-217176_19652470.0Topological domainExtracellular
HgeneLMBR1Lchr12:49500744chr19:38817233ENST00000547382-217218_30552470.0Topological domainCytoplasmic
HgeneLMBR1Lchr12:49500744chr19:38817233ENST00000547382-217327_35052470.0Topological domainExtracellular
HgeneLMBR1Lchr12:49500744chr19:38817233ENST00000547382-217372_38852470.0Topological domainCytoplasmic
HgeneLMBR1Lchr12:49500744chr19:38817233ENST00000547382-217410_43152470.0Topological domainExtracellular
HgeneLMBR1Lchr12:49500744chr19:38817233ENST00000547382-21743_6652470.0Topological domainCytoplasmic
HgeneLMBR1Lchr12:49500744chr19:38817233ENST00000547382-217453_48952470.0Topological domainCytoplasmic
HgeneLMBR1Lchr12:49500744chr19:38817233ENST00000547382-21788_11452470.0Topological domainExtracellular
HgeneLMBR1Lchr12:49500744chr19:38817233ENST00000267102-217115_13552490.0TransmembraneHelical
HgeneLMBR1Lchr12:49500744chr19:38817233ENST00000267102-217155_17552490.0TransmembraneHelical
HgeneLMBR1Lchr12:49500744chr19:38817233ENST00000267102-217197_21752490.0TransmembraneHelical
HgeneLMBR1Lchr12:49500744chr19:38817233ENST00000267102-217306_32652490.0TransmembraneHelical
HgeneLMBR1Lchr12:49500744chr19:38817233ENST00000267102-217351_37152490.0TransmembraneHelical
HgeneLMBR1Lchr12:49500744chr19:38817233ENST00000267102-217389_40952490.0TransmembraneHelical
HgeneLMBR1Lchr12:49500744chr19:38817233ENST00000267102-217432_45252490.0TransmembraneHelical
HgeneLMBR1Lchr12:49500744chr19:38817233ENST00000267102-21767_8752490.0TransmembraneHelical
HgeneLMBR1Lchr12:49500744chr19:38817233ENST00000395141-116115_1350485.0TransmembraneHelical
HgeneLMBR1Lchr12:49500744chr19:38817233ENST00000395141-116155_1750485.0TransmembraneHelical
HgeneLMBR1Lchr12:49500744chr19:38817233ENST00000395141-116197_2170485.0TransmembraneHelical
HgeneLMBR1Lchr12:49500744chr19:38817233ENST00000395141-11622_420485.0TransmembraneHelical
HgeneLMBR1Lchr12:49500744chr19:38817233ENST00000395141-116306_3260485.0TransmembraneHelical
HgeneLMBR1Lchr12:49500744chr19:38817233ENST00000395141-116351_3710485.0TransmembraneHelical
HgeneLMBR1Lchr12:49500744chr19:38817233ENST00000395141-116389_4090485.0TransmembraneHelical
HgeneLMBR1Lchr12:49500744chr19:38817233ENST00000395141-116432_4520485.0TransmembraneHelical
HgeneLMBR1Lchr12:49500744chr19:38817233ENST00000395141-11667_870485.0TransmembraneHelical
HgeneLMBR1Lchr12:49500744chr19:38817233ENST00000547382-217115_13552470.0TransmembraneHelical
HgeneLMBR1Lchr12:49500744chr19:38817233ENST00000547382-217155_17552470.0TransmembraneHelical
HgeneLMBR1Lchr12:49500744chr19:38817233ENST00000547382-217197_21752470.0TransmembraneHelical
HgeneLMBR1Lchr12:49500744chr19:38817233ENST00000547382-217306_32652470.0TransmembraneHelical
HgeneLMBR1Lchr12:49500744chr19:38817233ENST00000547382-217351_37152470.0TransmembraneHelical
HgeneLMBR1Lchr12:49500744chr19:38817233ENST00000547382-217389_40952470.0TransmembraneHelical
HgeneLMBR1Lchr12:49500744chr19:38817233ENST00000547382-217432_45252470.0TransmembraneHelical
HgeneLMBR1Lchr12:49500744chr19:38817233ENST00000547382-21767_8752470.0TransmembraneHelical
TgeneKCNK6chr12:49500744chr19:38817233ENST000002633720390_115107314.0IntramembranePore-forming%3B Name%3DPore-forming 1
TgeneKCNK6chr12:49500744chr19:38817233ENST00000263372031_4107314.0Topological domainCytoplasmic
TgeneKCNK6chr12:49500744chr19:38817233ENST00000263372035_25107314.0TransmembraneHelical


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Fusion Gene Sequence for LMBR1L-KCNK6


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>45737_45737_1_LMBR1L-KCNK6_LMBR1L_chr12_49500744_ENST00000267102_KCNK6_chr19_38817233_ENST00000263372_length(transcript)=2737nt_BP=500nt
TGTGTCGTCACTAGATCTCTTAAAAAGATGGACCCTCAGCGGCGCTTCCTCGTAGCGAGCCTAGTGGCGGGTGTTTGCATTGAAACGTGA
GCGCGACCCGACCTTAAAGAGTGGGGAGCAAAGGGAGGACAGAGCCCTTTAAAACGAGGCGGGTGGTGCCTGCCCCTTTAAGGGCGGGGC
GTCCGGACGACTGTATCTGAGCCCCAGACTGCCCCGAGTTTCTGTCGCAGGCTGCGAGGAAAGGCCCCTAGGCTGGGTCTGGGTGCTTGG
CGGCGGCGGCTTCCTCCCCGCTCGTCCTCCCCGGGCCCAGAGGCACCTCGGCTTCAGTCATGCTGAGCAGAGTATGGAAGCACCTGACTA
CGAAGTGCTATCCGTGCGAGAACAGCTATTCCACGAGAGGATCCGCGAGTGTATTATATCAACACTTCTGTTTGCAACACTGTACATCCT
CTGCCACATCTTCCTGACCCGCTTCAAGAAGCCTGCTGAGTTCACCACAGGCTATGGGTACACAACGCCACTGACTGATGCGGGCAAGGC
CTTCTCCATCGCCTTTGCGCTCCTGGGCGTGCCGACCACCATGCTGCTGCTGACCGCCTCAGCCCAGCGCCTGTCACTGCTGCTGACTCA
CGTGCCCCTGTCTTGGCTGAGCATGCGTTGGGGCTGGGACCCCCGGCGGGCGGCCTGCTGGCACTTGGTGGCCCTGTTGGGGGTCGTAGT
GACCGTCTGCTTTCTGGTGCCGGCTGTGATCTTTGCCCACCTCGAGGAGGCCTGGAGCTTCTTGGATGCCTTCTACTTCTGCTTTATCTC
TCTGTCCACCATCGGCCTGGGCGACTACGTGCCCGGGGAGGCCCCTGGCCAGCCCTACCGGGCCCTCTACAAGGTGCTGGTCACAGTCTA
CCTCTTCCTGGGCCTGGTGGCCATGGTGCTGGTGCTGCAGACCTTCCGCCACGTGTCCGACCTCCACGGCCTCACGGAGCTCATCCTGCT
GCCCCCTCCGTGCCCTGCCAGTTTCAATGCGGATGAGGACGATCGGGTGGACATCCTGGGCCCCCAGCCGGAGTCGCACCAGCAACTCTC
TGCCAGCTCCCACACCGACTACGCTTCCATCCCCAGGTAGCTGGGGCAGCCTCTGCCAGGCTTGGGTGTGCCTGGCCTGGGACTGAGGGG
TCCAGGCGACCAGAGCTGGCTGTACAGGAATGTCCACGAGCACAGCAGGTGATCTTGAGGCCTTGCCGTCCACCGTCTCTCCTTTGTTTC
CCAGCATCTGGCTGGGATGTGAAGGGCAGCACTCCCTGTCCCCATGTCCCGGGCTCCACTGGGCACCAACATAACCTTGTTCTCTGTCCT
TTCTCTCATCCTCTTTACACTGTGTCTCTCTGGCTCTCTGGCATTCTCGCTGCCTCTGTCTTTCCCTCTTGCTGTCTCTGTTTCTCATTC
TCTTTCATGTTCCGTCTGTGTCTCTCAATTAACCACTCGTCAACTGCTGATTCTACTGGGCTGTGGGCTCAGACCTCATTTCAGGCACCA
GATTGGTCGCTACACCCTGGACAAGTGACTGCCCGTCTCTGAGCCTTGATTTCCTCAGCTGCCAAATGGGAAGAATAGAAGAATTTGCCC
CTAAACCCCTCCTGTGTGCTGGCCCTGTGCTAGACAGTGCTGGAGACATAGTTGGGGGTGGAGAACTGCCCTTATGGAGCTTGCAGTCCA
GTGAGGTGGACAGACCTGTCCCCAGACAGTGATGGCCCAAAATGGTCAGGACTTTAATGGAGGAGGTGAGGTGTTGAAAGCACAGGCAGA
GTGGTCAGGGCTGAAGTCGGAGAAGCATAGGGACTAGGCCCAATCCAGCCTGGAAAGTCAGGGAGGACTTCCTAGAGGAAGGGACATCGA
ACTAAGACCTGAACTATGAGAAATAGGCAGGAAGAAGTTGTACCTGACTCATTTTTCTCAGGTGTCTCCAGGGAGCAGGACCCATGGAGG
GACCCCTGGTGTAGGCCTGGGCGATAGACTCTTCCTCAGCAGCCTGGCAGGCAGGAAACAGACATAGGACCCCAGCCCAGATCTGAATGG
CATGGGAGGTGCTGCCCTTAACCATGACACCATTGTAAGAGCTGTCCACATTTGTATGTTGTGCCCTGGAATCAGCCTGGTTGAGCTCAA
ATCCCAACTTAGCCACGTCTGGCCTGTGTCCTTGGGCAGTCACACTACCTCTCTGATTTTGTTTCCTTATCTGTAAAATGGTGATCATCA
TAATACAACTTCAAAAGGATTTCAGGCTGAGTGTGGTGGCTCACGCCTATACACCCAGCACTTTGGAAGGCTGAGGAAGGAGGATCGCTT
GAGGCCAGGAGTTTGAGACTAGCCTAGGCAACACAGTGAGGCCTTATCTCAACAACAACCACAAAATCTAAAAATTAGCTGGGTGTGGTG
GTGCATGCCTGTGATCCTGGCTACTTCAGAGGCTGAGGTGGAAGGATCACTTGAGGCCAGGAGTTTGAGGCTGCAGTGAGTTATGATGGC
ACTGCTGCACTCCAGCCTGCGGGACAGAGTGAGACCCTGTCTGAAAGAAAGAGAGAAAGAAAGAAAGAAAGAGAGAGAAAGAAAGAAAGA
AAGAAAGGGAAAGATGGAAGGAAGGAAGGAAAAAGAAAGAGAAAGAGAGAGAGAGAGAAAGAAAAAGAAAGAAAAGTAAGAAAGAAAAAA

>45737_45737_1_LMBR1L-KCNK6_LMBR1L_chr12_49500744_ENST00000267102_KCNK6_chr19_38817233_ENST00000263372_length(amino acids)=309AA_BP=103
MYLSPRLPRVSVAGCEERPLGWVWVLGGGGFLPARPPRAQRHLGFSHAEQSMEAPDYEVLSVREQLFHERIRECIISTLLFATLYILCHI
FLTRFKKPAEFTTGYGYTTPLTDAGKAFSIAFALLGVPTTMLLLTASAQRLSLLLTHVPLSWLSMRWGWDPRRAACWHLVALLGVVVTVC
FLVPAVIFAHLEEAWSFLDAFYFCFISLSTIGLGDYVPGEAPGQPYRALYKVLVTVYLFLGLVAMVLVLQTFRHVSDLHGLTELILLPPP

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>45737_45737_2_LMBR1L-KCNK6_LMBR1L_chr12_49500744_ENST00000547382_KCNK6_chr19_38817233_ENST00000263372_length(transcript)=2689nt_BP=452nt
CTCGTAGCGAGCCTAGTGGCGGGTGTTTGCATTGAAACGTGAGCGCGACCCGACCTTAAAGAGTGGGGAGCAAAGGGAGGACAGAGCCCT
TTAAAACGAGGCGGGTGGTGCCTGCCCCTTTAAGGGCGGGGCGTCCGGACGACTGTATCTGAGCCCCAGACTGCCCCGAGTTTCTGTCGC
AGGCTGCGAGGAAAGGCCCCTAGGCTGGGTCTGGGTGCTTGGCGGCGGCGGCTTCCTCCCCGCTCGTCCTCCCCGGGCCCAGAGGCACCT
CGGCTTCAGTCATGCTGAGCAGAGTATGGAAGCACCTGACTACGAAGTGCTATCCGTGCGAGAACAGCTATTCCACGAGAGGATCCGCGA
GTGTATTATATCAACACTTCTGTTTGCAACACTGTACATCCTCTGCCACATCTTCCTGACCCGCTTCAAGAAGCCTGCTGAGTTCACCAC
AGGCTATGGGTACACAACGCCACTGACTGATGCGGGCAAGGCCTTCTCCATCGCCTTTGCGCTCCTGGGCGTGCCGACCACCATGCTGCT
GCTGACCGCCTCAGCCCAGCGCCTGTCACTGCTGCTGACTCACGTGCCCCTGTCTTGGCTGAGCATGCGTTGGGGCTGGGACCCCCGGCG
GGCGGCCTGCTGGCACTTGGTGGCCCTGTTGGGGGTCGTAGTGACCGTCTGCTTTCTGGTGCCGGCTGTGATCTTTGCCCACCTCGAGGA
GGCCTGGAGCTTCTTGGATGCCTTCTACTTCTGCTTTATCTCTCTGTCCACCATCGGCCTGGGCGACTACGTGCCCGGGGAGGCCCCTGG
CCAGCCCTACCGGGCCCTCTACAAGGTGCTGGTCACAGTCTACCTCTTCCTGGGCCTGGTGGCCATGGTGCTGGTGCTGCAGACCTTCCG
CCACGTGTCCGACCTCCACGGCCTCACGGAGCTCATCCTGCTGCCCCCTCCGTGCCCTGCCAGTTTCAATGCGGATGAGGACGATCGGGT
GGACATCCTGGGCCCCCAGCCGGAGTCGCACCAGCAACTCTCTGCCAGCTCCCACACCGACTACGCTTCCATCCCCAGGTAGCTGGGGCA
GCCTCTGCCAGGCTTGGGTGTGCCTGGCCTGGGACTGAGGGGTCCAGGCGACCAGAGCTGGCTGTACAGGAATGTCCACGAGCACAGCAG
GTGATCTTGAGGCCTTGCCGTCCACCGTCTCTCCTTTGTTTCCCAGCATCTGGCTGGGATGTGAAGGGCAGCACTCCCTGTCCCCATGTC
CCGGGCTCCACTGGGCACCAACATAACCTTGTTCTCTGTCCTTTCTCTCATCCTCTTTACACTGTGTCTCTCTGGCTCTCTGGCATTCTC
GCTGCCTCTGTCTTTCCCTCTTGCTGTCTCTGTTTCTCATTCTCTTTCATGTTCCGTCTGTGTCTCTCAATTAACCACTCGTCAACTGCT
GATTCTACTGGGCTGTGGGCTCAGACCTCATTTCAGGCACCAGATTGGTCGCTACACCCTGGACAAGTGACTGCCCGTCTCTGAGCCTTG
ATTTCCTCAGCTGCCAAATGGGAAGAATAGAAGAATTTGCCCCTAAACCCCTCCTGTGTGCTGGCCCTGTGCTAGACAGTGCTGGAGACA
TAGTTGGGGGTGGAGAACTGCCCTTATGGAGCTTGCAGTCCAGTGAGGTGGACAGACCTGTCCCCAGACAGTGATGGCCCAAAATGGTCA
GGACTTTAATGGAGGAGGTGAGGTGTTGAAAGCACAGGCAGAGTGGTCAGGGCTGAAGTCGGAGAAGCATAGGGACTAGGCCCAATCCAG
CCTGGAAAGTCAGGGAGGACTTCCTAGAGGAAGGGACATCGAACTAAGACCTGAACTATGAGAAATAGGCAGGAAGAAGTTGTACCTGAC
TCATTTTTCTCAGGTGTCTCCAGGGAGCAGGACCCATGGAGGGACCCCTGGTGTAGGCCTGGGCGATAGACTCTTCCTCAGCAGCCTGGC
AGGCAGGAAACAGACATAGGACCCCAGCCCAGATCTGAATGGCATGGGAGGTGCTGCCCTTAACCATGACACCATTGTAAGAGCTGTCCA
CATTTGTATGTTGTGCCCTGGAATCAGCCTGGTTGAGCTCAAATCCCAACTTAGCCACGTCTGGCCTGTGTCCTTGGGCAGTCACACTAC
CTCTCTGATTTTGTTTCCTTATCTGTAAAATGGTGATCATCATAATACAACTTCAAAAGGATTTCAGGCTGAGTGTGGTGGCTCACGCCT
ATACACCCAGCACTTTGGAAGGCTGAGGAAGGAGGATCGCTTGAGGCCAGGAGTTTGAGACTAGCCTAGGCAACACAGTGAGGCCTTATC
TCAACAACAACCACAAAATCTAAAAATTAGCTGGGTGTGGTGGTGCATGCCTGTGATCCTGGCTACTTCAGAGGCTGAGGTGGAAGGATC
ACTTGAGGCCAGGAGTTTGAGGCTGCAGTGAGTTATGATGGCACTGCTGCACTCCAGCCTGCGGGACAGAGTGAGACCCTGTCTGAAAGA
AAGAGAGAAAGAAAGAAAGAAAGAGAGAGAAAGAAAGAAAGAAAGAAAGGGAAAGATGGAAGGAAGGAAGGAAAAAGAAAGAGAAAGAGA

>45737_45737_2_LMBR1L-KCNK6_LMBR1L_chr12_49500744_ENST00000547382_KCNK6_chr19_38817233_ENST00000263372_length(amino acids)=309AA_BP=103
MYLSPRLPRVSVAGCEERPLGWVWVLGGGGFLPARPPRAQRHLGFSHAEQSMEAPDYEVLSVREQLFHERIRECIISTLLFATLYILCHI
FLTRFKKPAEFTTGYGYTTPLTDAGKAFSIAFALLGVPTTMLLLTASAQRLSLLLTHVPLSWLSMRWGWDPRRAACWHLVALLGVVVTVC
FLVPAVIFAHLEEAWSFLDAFYFCFISLSTIGLGDYVPGEAPGQPYRALYKVLVTVYLFLGLVAMVLVLQTFRHVSDLHGLTELILLPPP

--------------------------------------------------------------

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Fusion Gene PPI Analysis for LMBR1L-KCNK6


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneLMBR1Lchr12:49500744chr19:38817233ENST00000267102-2171_5952.333333333333336490.0LGB
HgeneLMBR1Lchr12:49500744chr19:38817233ENST00000395141-1161_590.0485.0LGB
HgeneLMBR1Lchr12:49500744chr19:38817233ENST00000547382-2171_5952.333333333333336470.0LGB


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for LMBR1L-KCNK6


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for LMBR1L-KCNK6


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource