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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:LMBR1-UBE3C (FusionGDB2 ID:45751)

Fusion Gene Summary for LMBR1-UBE3C

check button Fusion gene summary
Fusion gene informationFusion gene name: LMBR1-UBE3C
Fusion gene ID: 45751
HgeneTgene
Gene symbol

LMBR1

UBE3C

Gene ID

64327

9690

Gene namelimb development membrane protein 1ubiquitin protein ligase E3C
SynonymsACHP|C7orf2|DIF14|LSS|PPD2|THYP|TPT|ZRSHECTH2
Cytomap

7q36.3

7q36.3

Type of geneprotein-codingprotein-coding
Descriptionlimb region 1 protein homologdifferentiation-related gene 14 proteinlimb region 1 homologubiquitin-protein ligase E3CHECT-type ubiquitin transferase E3Cubiquitin-protein isopeptide ligase (E3)
Modification date2020031320200313
UniProtAcc

Q8WVP7

.
Ensembl transtripts involved in fusion geneENST00000353442, ENST00000354505, 
ENST00000540390, ENST00000359422, 
ENST00000430825, 		ENST00000348165, 
ENST00000389103, 
Fusion gene scores* DoF score14 X 11 X 12=184811 X 13 X 7=1001
# samples 2013
** MAII scorelog2(20/1848*10)=-3.20789285164133
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/1001*10)=-2.94485844580754
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: LMBR1 [Title/Abstract] AND UBE3C [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointLMBR1(156685622)-UBE3C(156979528), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneUBE3C

GO:0000209

protein polyubiquitination

11278995


check buttonFusion gene breakpoints across LMBR1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across UBE3C (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-DX-A6Z0-01ALMBR1chr7

156685622

-UBE3Cchr7

156979528

+


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Fusion Gene ORF analysis for LMBR1-UBE3C

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000353442ENST00000348165LMBR1chr7

156685622

-UBE3Cchr7

156979528

+
In-frameENST00000353442ENST00000389103LMBR1chr7

156685622

-UBE3Cchr7

156979528

+
In-frameENST00000354505ENST00000348165LMBR1chr7

156685622

-UBE3Cchr7

156979528

+
In-frameENST00000354505ENST00000389103LMBR1chr7

156685622

-UBE3Cchr7

156979528

+
In-frameENST00000540390ENST00000348165LMBR1chr7

156685622

-UBE3Cchr7

156979528

+
In-frameENST00000540390ENST00000389103LMBR1chr7

156685622

-UBE3Cchr7

156979528

+
intron-3CDSENST00000359422ENST00000348165LMBR1chr7

156685622

-UBE3Cchr7

156979528

+
intron-3CDSENST00000359422ENST00000389103LMBR1chr7

156685622

-UBE3Cchr7

156979528

+
intron-3CDSENST00000430825ENST00000348165LMBR1chr7

156685622

-UBE3Cchr7

156979528

+
intron-3CDSENST00000430825ENST00000389103LMBR1chr7

156685622

-UBE3Cchr7

156979528

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000353442LMBR1chr7156685622-ENST00000348165UBE3Cchr7156979528+40293032372411724
ENST00000353442LMBR1chr7156685622-ENST00000389103UBE3Cchr7156979528+8373035772192
ENST00000354505LMBR1chr7156685622-ENST00000348165UBE3Cchr7156979528+39462201542328724
ENST00000354505LMBR1chr7156685622-ENST00000389103UBE3Cchr7156979528+7542204940165
ENST00000540390LMBR1chr7156685622-ENST00000348165UBE3Cchr7156979528+39782521862360724
ENST00000540390LMBR1chr7156685622-ENST00000389103UBE3Cchr7156979528+7862525262175

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000353442ENST00000348165LMBR1chr7156685622-UBE3Cchr7156979528+0.0010576170.99894243
ENST00000353442ENST00000389103LMBR1chr7156685622-UBE3Cchr7156979528+0.239798490.7602015
ENST00000354505ENST00000348165LMBR1chr7156685622-UBE3Cchr7156979528+0.0009662680.9990338
ENST00000354505ENST00000389103LMBR1chr7156685622-UBE3Cchr7156979528+0.259402280.7405977
ENST00000540390ENST00000348165LMBR1chr7156685622-UBE3Cchr7156979528+0.0010520680.9989479
ENST00000540390ENST00000389103LMBR1chr7156685622-UBE3Cchr7156979528+0.251499740.7485003

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Fusion Genomic Features for LMBR1-UBE3C


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
LMBR1chr7156685621-UBE3Cchr7156979527+2.58E-091
LMBR1chr7156685621-UBE3Cchr7156979527+2.58E-091

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for LMBR1-UBE3C


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:156685622/chr7:156979528)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LMBR1

Q8WVP7

.
FUNCTION: Putative membrane receptor.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLMBR1chr7:156685622chr7:156979528ENST00000353442-1171_1922491.0Topological domainExtracellular
HgeneLMBR1chr7:156685622chr7:156979528ENST00000354505-1181_1922532.0Topological domainExtracellular
TgeneUBE3Cchr7:156685622chr7:156979528ENST00000348165823744_10833811084.0DomainHECT
TgeneUBE3Cchr7:156685622chr7:156979528ENST0000038910369744_1083338405.0DomainHECT

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLMBR1chr7:156685622chr7:156979528ENST00000353442-117250_28722491.0Coiled coilOntology_term=ECO:0000255
HgeneLMBR1chr7:156685622chr7:156979528ENST00000354505-118250_28722532.0Coiled coilOntology_term=ECO:0000255
HgeneLMBR1chr7:156685622chr7:156979528ENST00000353442-117132_15122491.0Topological domainCytoplasmic
HgeneLMBR1chr7:156685622chr7:156979528ENST00000353442-117173_18722491.0Topological domainExtracellular
HgeneLMBR1chr7:156685622chr7:156979528ENST00000353442-117209_29122491.0Topological domainCytoplasmic
HgeneLMBR1chr7:156685622chr7:156979528ENST00000353442-117313_33922491.0Topological domainExtracellular
HgeneLMBR1chr7:156685622chr7:156979528ENST00000353442-117361_38322491.0Topological domainCytoplasmic
HgeneLMBR1chr7:156685622chr7:156979528ENST00000353442-117405_42622491.0Topological domainExtracellular
HgeneLMBR1chr7:156685622chr7:156979528ENST00000353442-11741_6222491.0Topological domainCytoplasmic
HgeneLMBR1chr7:156685622chr7:156979528ENST00000353442-117448_49022491.0Topological domainCytoplasmic
HgeneLMBR1chr7:156685622chr7:156979528ENST00000353442-11784_11022491.0Topological domainExtracellular
HgeneLMBR1chr7:156685622chr7:156979528ENST00000354505-118132_15122532.0Topological domainCytoplasmic
HgeneLMBR1chr7:156685622chr7:156979528ENST00000354505-118173_18722532.0Topological domainExtracellular
HgeneLMBR1chr7:156685622chr7:156979528ENST00000354505-118209_29122532.0Topological domainCytoplasmic
HgeneLMBR1chr7:156685622chr7:156979528ENST00000354505-118313_33922532.0Topological domainExtracellular
HgeneLMBR1chr7:156685622chr7:156979528ENST00000354505-118361_38322532.0Topological domainCytoplasmic
HgeneLMBR1chr7:156685622chr7:156979528ENST00000354505-118405_42622532.0Topological domainExtracellular
HgeneLMBR1chr7:156685622chr7:156979528ENST00000354505-11841_6222532.0Topological domainCytoplasmic
HgeneLMBR1chr7:156685622chr7:156979528ENST00000354505-118448_49022532.0Topological domainCytoplasmic
HgeneLMBR1chr7:156685622chr7:156979528ENST00000354505-11884_11022532.0Topological domainExtracellular
HgeneLMBR1chr7:156685622chr7:156979528ENST00000353442-117111_13122491.0TransmembraneHelical
HgeneLMBR1chr7:156685622chr7:156979528ENST00000353442-117152_17222491.0TransmembraneHelical
HgeneLMBR1chr7:156685622chr7:156979528ENST00000353442-117188_20822491.0TransmembraneHelical
HgeneLMBR1chr7:156685622chr7:156979528ENST00000353442-11720_4022491.0TransmembraneHelical
HgeneLMBR1chr7:156685622chr7:156979528ENST00000353442-117292_31222491.0TransmembraneHelical
HgeneLMBR1chr7:156685622chr7:156979528ENST00000353442-117340_36022491.0TransmembraneHelical
HgeneLMBR1chr7:156685622chr7:156979528ENST00000353442-117384_40422491.0TransmembraneHelical
HgeneLMBR1chr7:156685622chr7:156979528ENST00000353442-117427_44722491.0TransmembraneHelical
HgeneLMBR1chr7:156685622chr7:156979528ENST00000353442-11763_8322491.0TransmembraneHelical
HgeneLMBR1chr7:156685622chr7:156979528ENST00000354505-118111_13122532.0TransmembraneHelical
HgeneLMBR1chr7:156685622chr7:156979528ENST00000354505-118152_17222532.0TransmembraneHelical
HgeneLMBR1chr7:156685622chr7:156979528ENST00000354505-118188_20822532.0TransmembraneHelical
HgeneLMBR1chr7:156685622chr7:156979528ENST00000354505-11820_4022532.0TransmembraneHelical
HgeneLMBR1chr7:156685622chr7:156979528ENST00000354505-118292_31222532.0TransmembraneHelical
HgeneLMBR1chr7:156685622chr7:156979528ENST00000354505-118340_36022532.0TransmembraneHelical
HgeneLMBR1chr7:156685622chr7:156979528ENST00000354505-118384_40422532.0TransmembraneHelical
HgeneLMBR1chr7:156685622chr7:156979528ENST00000354505-118427_44722532.0TransmembraneHelical
HgeneLMBR1chr7:156685622chr7:156979528ENST00000354505-11863_8322532.0TransmembraneHelical
TgeneUBE3Cchr7:156685622chr7:156979528ENST0000034816582345_743811084.0DomainIQ
TgeneUBE3Cchr7:156685622chr7:156979528ENST000003891036945_74338405.0DomainIQ
TgeneUBE3Cchr7:156685622chr7:156979528ENST000003481658231_603811084.0RegionNote=Cis-determinant of acceptor ubiquitin-binding
TgeneUBE3Cchr7:156685622chr7:156979528ENST00000389103691_60338405.0RegionNote=Cis-determinant of acceptor ubiquitin-binding


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Fusion Gene Sequence for LMBR1-UBE3C


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>45751_45751_1_LMBR1-UBE3C_LMBR1_chr7_156685622_ENST00000353442_UBE3C_chr7_156979528_ENST00000348165_length(transcript)=4029nt_BP=303nt
GCCCCGCCCCCGCCCCGCCCCCGACTGCGCGGCGCCCGCCCTCCCTTAGTCAGAGCTGCTCGTCTGAGGCTGCTGAGGCGACGGCCGGTG
TCGTGGTCGCGGTACCTGTTCCAACACGGCTCGCGGGCCCGTGCCGGCTCCGGTCCCCGGCGCGGCTGTCCGAGCCCCTGCGGCGGGCGG
ACGATGGTGTGGCGGAGCACGCGGACGCGGGCGGCGCGGCGGCGGGCATGAAGGAGGATGGAAGGGCAGGACGAGGTGTCGGCGCGGGAG
CAGCACTTCCACAGCCAAGTGCGGGAGTCCACGGAGGATGGCAGACTGTCAGTATCATACATAACAGAGGAATGCCTGAAGAAGCTGGAC
ACAAAGCAGCAGACCAACACCCTGCTCAACCTGGTGTGGAGGGACTCTGCGAGCGAGGAGGTCTTCACCACCATGGCCTCCGTCTGCCAC
ACGCTGATGGTGCAGCACCGCATGATGGTACCCAAAGTCAGGCTTCTCTACAGTTTAGCCTTTAATGCCAGGTTTCTGAGACATCTTTGG
TTTCTAATATCTTCCATGTCAACACGGATGATCACAGGGTCTATGGTACCGTTGCTTCAGGTGATATCCAGGGGTTCTCCTATGTCTTTT
GAAGATTCTAGTCGAATCATCCCACTCTTTTATCTTTTTAGCTCCTTGTTTAGTCATTCACTAATTTCCATACATGATAACGAATTCTTC
GGTGATCCCATAGAAGTTGTAGGTCAAAGACAATCATCAATGATGCCTTTTACTTTAGAAGAGCTGATAATGTTGTCTCGATGCCTTCGA
GATGCATGCCTGGGGATCATCAAGTTGGCTTATCCAGAAACCAAGCCAGAAGTTCGAGAAGAATATATTACAGCATTTCAGAGTATTGGA
GTTACTACTAGCTCTGAAATGCAACAATGCATACAGATGGAACAGAAAAGATGGATTCAGTTATTTAAGGTTATCACCAATCTAGTGAAA
ATGTTGAAGTCCAGAGACACGAGGAGAAATTTTTGTCCTCCAAACCACTGGCTGTCAGAACAAGAAGATATTAAAGCAGATAAGGTCACT
CAGCTCTATGTGCCAGCATCCAGACATGTGTGGAGGTTCCGGCGGATGGGGAGGATAGGCCCGCTGCAGTCCACCCTGGACGTGGGTTTG
GAGTCCCCGCCGCTGTCTGTGTCTGAGGAAAGACAGCTTGCTGTCCTGACAGAGTTGCCTTTTGTGGTTCCATTTGAGGAACGAGTAAAG
ATCTTTCAGAGGTTGATTTATGCAGATAAGCAAGAAGTTCAAGGAGATGGTCCATTTCTGGATGGAATTAATGTCACAATAAGAAGAAAT
TACATTTATGAAGATGCTTATGACAAACTTTCTCCAGAAAATGAGCCTGATTTGAAAAAGCGGATCCGTGTGCACTTGCTCAATGCCCAT
GGCCTGGATGAAGCTGGCATTGATGGTGGTGGTATTTTCAGAGAGTTTTTAAATGAACTACTGAAGTCAGGATTTAACCCCAACCAGGGG
TTCTTTAAGACTACTAATGAAGGGCTTCTGTACCCCAACCCGGCTGCTCAGATGCTTGTGGGAGATTCTTTTGCCAGACATTACTACTTC
CTAGGCAGAATGCTTGGAAAGGCTCTCTATGAGAACATGCTGGTGGAGCTGCCCTTTGCAGGCTTCTTTCTTTCCAAGTTGCTTGGAACC
AGTGCCGACGTGGACATTCACCACCTCGCCTCCCTAGACCCTGAGGTGTATAAGAATTTGCTCTTTCTGAAGAGCTACGAAGACGATGTG
GAGGAGCTTGGGCTGAACTTCACTGTGGTGAACAATGACCTGGGAGAGGCGCAGGTAGTTGAACTAAAATTCGGTGGGAAAGACATCCCT
GTCACCAGCGCCAACCGGATTGCGTACATCCACTTGGTGGCAGACTACAGGCTGAACAGGCAGATCCGCCAGCACTGCCTGGCTTTCCGC
CAGGGCCTTGCCAATGTCGTCAGCCTCGAGTGGCTCCGAATGTTTGATCAGCAAGAAATTCAGGTATTAATTTCTGGTGCACAAGTTCCC
ATAAGCCTAGAGGACCTAAAATCCTTTACAAACTATTCAGGAGGCTATTCTGCAGACCATCCTGTTATTAAGGTCTTCTGGAGAGTTGTG
GAAGGGTTCACTGATGAAGAAAAGCGCAAACTGCTGAAGTTTGTAACAAGCTGCTCTCGACCCCCTCTCTTGGGGTTTAAGGAGTTGTAT
CCCGCATTTTGTATTCACAACGGAGGCTCCGACCTTGAGCGGCTCCCCACAGCCAGCACCTGCATGAACCTGCTGAAGCTCCCCGAGTTC
TATGACGAGACACTTTTGCGAAGTAAACTTCTCTATGCGATTGAATGTGCCGCTGGCTTTGAGCTGAGCTGAAGCTGATGCTGGGGTCAG
ACCCCTACAGAGAACCAGTGCTTCCTTCGTCAGCAGCGCCTCCCCAGACCCACGAGGATACTCACACTGCACGCCTGAGGCTCTCCTAAG
CTCCTTCTTTCATTCTGCCATTCCTCCCTCCCTTCCTTTTTTAAATGATTTTTATTACGGTGTGGTCACTTATTTAGATGGACATTGCTT
TTCAAATAACTTAAAATAACACGTTATGTGCCATGTGGCTACTTTAGTAATATTGCCAAGAAGAGCACAGTTTTTACACTAGTGGCATCT
CAGTGAAATTAACCAAAGATGAAGCTTTGGCTTTGCTGGTGAGATCAGAGCCCTCCTGAGCAGGCAGCGCCACTCCAGGGTTCAGACAGG
GCTGCACAGGCGGCAGAGATACAGGGTCTGAGGGCTGAGACGCCATGGGGCCGCTGCTGCTTATGTGGTTGGATTGTTTACAAGCCTCAT
TATTAAAACTGAAGGCATTTTTTTTTTCTGCTGCCTTTCCCAAAGTGGTTAGGTTTGGAAAAGAGATGATGATGGTAATATTTTATTTGT
GCTTTTTAAGCCATTTCCCCAAATGGGACTAGCATGCTTGTTTTCAGTATACCGTGGCCTGCCTCATGATGGTTTGGAGATACTGTCTGT
GGATGTGAGGTGGGGACTTCATTCATTGTCCTATTTCTATCTCCACTTTGTGCCTGGAGAGCTTTCAGGGGAGGTGGAGGAGGAGGGTCT
GCCAAGCTACTGCAACATCTGTCACCCACTATACCCAGTTACTTGGGGGAGGACAGACACTGTGGTGTCATTAAAGTTGTTTGAACCAAA
GTGGCGGCTGCATCTTTGTCCCGATGCTAGCCGTGCCGGTCTCCCATCATCCGCTCGCCCTCCTTTCCCCTGGGCTGCGCCCACTTGTCT
TCCTGGATATTTGGGGGTGACTCGCCATGCTTGGCACCCTCTGCTTCCTGGTGCTGCTCTGACTCGAAGACGGGACAGTCCCTGGTGCAC
ATCCAGGGAAGAGGAGTGTCGGTAGTTCTTGCAGTAGGCACTTTATCAGGACCTGACCTGTTGCTGGGTGATTTTAGTCTCTACAAACAG
AAAGCGTTTCAAAGCGTCAGCTGTGGGAGCAGAGTGACCCTTTGCTGATGCTGGGGGGAGGGGATCTAAATCCTCATTTATCTCTTCTAT
GTCTCGTATTTTACTGTCACTGGAGGCTCTGTGGGCTGTCATAGTTAATTGACCATAATTAGCAATATACTTTTAAAGTGGGAAAGCTGA
ATGACACTTTTAAGACAATGAACATTATCAAAACAAAATGTATAATTTCTTAATTTGAATAATAAATTAAGCGTTTAAATGCTATTTGTA
GTCTTGATATACAGAAATAAAATAATTAGGGTTGGTCTTTTTTATTTTAGGTTGTTTTATGTTGAATGTTCTATATCTTATTAGTTAATT
TGTATATTTTATTAGTATTTTGGAAATAGCATATCTGAGACTGAAGAGAAATTGACAATTCACTTATTTGTGGTTTTTTTCTCAGCTATT

>45751_45751_1_LMBR1-UBE3C_LMBR1_chr7_156685622_ENST00000353442_UBE3C_chr7_156979528_ENST00000348165_length(amino acids)=724AA_BP=22
MEGQDEVSAREQHFHSQVRESTEDGRLSVSYITEECLKKLDTKQQTNTLLNLVWRDSASEEVFTTMASVCHTLMVQHRMMVPKVRLLYSL
AFNARFLRHLWFLISSMSTRMITGSMVPLLQVISRGSPMSFEDSSRIIPLFYLFSSLFSHSLISIHDNEFFGDPIEVVGQRQSSMMPFTL
EELIMLSRCLRDACLGIIKLAYPETKPEVREEYITAFQSIGVTTSSEMQQCIQMEQKRWIQLFKVITNLVKMLKSRDTRRNFCPPNHWLS
EQEDIKADKVTQLYVPASRHVWRFRRMGRIGPLQSTLDVGLESPPLSVSEERQLAVLTELPFVVPFEERVKIFQRLIYADKQEVQGDGPF
LDGINVTIRRNYIYEDAYDKLSPENEPDLKKRIRVHLLNAHGLDEAGIDGGGIFREFLNELLKSGFNPNQGFFKTTNEGLLYPNPAAQML
VGDSFARHYYFLGRMLGKALYENMLVELPFAGFFLSKLLGTSADVDIHHLASLDPEVYKNLLFLKSYEDDVEELGLNFTVVNNDLGEAQV
VELKFGGKDIPVTSANRIAYIHLVADYRLNRQIRQHCLAFRQGLANVVSLEWLRMFDQQEIQVLISGAQVPISLEDLKSFTNYSGGYSAD
HPVIKVFWRVVEGFTDEEKRKLLKFVTSCSRPPLLGFKELYPAFCIHNGGSDLERLPTASTCMNLLKLPEFYDETLLRSKLLYAIECAAG

--------------------------------------------------------------
>45751_45751_2_LMBR1-UBE3C_LMBR1_chr7_156685622_ENST00000353442_UBE3C_chr7_156979528_ENST00000389103_length(transcript)=837nt_BP=303nt
GCCCCGCCCCCGCCCCGCCCCCGACTGCGCGGCGCCCGCCCTCCCTTAGTCAGAGCTGCTCGTCTGAGGCTGCTGAGGCGACGGCCGGTG
TCGTGGTCGCGGTACCTGTTCCAACACGGCTCGCGGGCCCGTGCCGGCTCCGGTCCCCGGCGCGGCTGTCCGAGCCCCTGCGGCGGGCGG
ACGATGGTGTGGCGGAGCACGCGGACGCGGGCGGCGCGGCGGCGGGCATGAAGGAGGATGGAAGGGCAGGACGAGGTGTCGGCGCGGGAG
CAGCACTTCCACAGCCAAGTGCGGGAGTCCACGGAGGATGGCAGACTGTCAGTATCATACATAACAGAGGAATGCCTGAAGAAGCTGGAC
ACAAAGCAGCAGACCAACACCCTGCTCAACCTGGTGTGGAGGGACTCTGCGAGCGAGGAGGTCTTCACCACCATGGCCTCCGTCTGCCAC
ACGCTGATGGTGCAGCACCGCATGATGGTACCCAAAGTCAGGGTGTACAAATGAATGTGGAGACCTTTGTACCCTGACATGGAAAGATTT
CCGAGACAGATGCGTACATGAAAACCGGGAAGACACAGGACAGTATGTAGAAGAACCGGCTTTTCCTATAAGAAGGATGGAAAAAATAGG
AATATATATTCATATTGCATAAAGAAACTTGGAAGCATATACAAGAAACTCATGAAAGTGAACACTCGTGTCTGAATATGCCGAGGAAGC
TGGGGCTGGAGCAGAAGTGCTCTTCTGAGTACACTATTTTTATATCACTTTTAAGTTTTGGATTAGGTGAATGACTTAATATTTTAAAAT

>45751_45751_2_LMBR1-UBE3C_LMBR1_chr7_156685622_ENST00000353442_UBE3C_chr7_156979528_ENST00000389103_length(amino acids)=192AA_BP=1
MCLPGFHVRICLGNLSMSGYKGLHIHLYTLTLGTIMRCCTISVWQTEAMVVKTSSLAESLHTRLSRVLVCCFVSSFFRHSSVMYDTDSLP
SSVDSRTWLWKCCSRADTSSCPSILLHARRRAARVRVLRHTIVRPPQGLGQPRRGPEPARAREPCWNRYRDHDTGRRLSSLRRAALTKGG

--------------------------------------------------------------
>45751_45751_3_LMBR1-UBE3C_LMBR1_chr7_156685622_ENST00000354505_UBE3C_chr7_156979528_ENST00000348165_length(transcript)=3946nt_BP=220nt
GCCGGTGTCGTGGTCGCGGTACCTGTTCCAACACGGCTCGCGGGCCCGTGCCGGCTCCGGTCCCCGGCGCGGCTGTCCGAGCCCCTGCGG
CGGGCGGACGATGGTGTGGCGGAGCACGCGGACGCGGGCGGCGCGGCGGCGGGCATGAAGGAGGATGGAAGGGCAGGACGAGGTGTCGGC
GCGGGAGCAGCACTTCCACAGCCAAGTGCGGGAGTCCACGGAGGATGGCAGACTGTCAGTATCATACATAACAGAGGAATGCCTGAAGAA
GCTGGACACAAAGCAGCAGACCAACACCCTGCTCAACCTGGTGTGGAGGGACTCTGCGAGCGAGGAGGTCTTCACCACCATGGCCTCCGT
CTGCCACACGCTGATGGTGCAGCACCGCATGATGGTACCCAAAGTCAGGCTTCTCTACAGTTTAGCCTTTAATGCCAGGTTTCTGAGACA
TCTTTGGTTTCTAATATCTTCCATGTCAACACGGATGATCACAGGGTCTATGGTACCGTTGCTTCAGGTGATATCCAGGGGTTCTCCTAT
GTCTTTTGAAGATTCTAGTCGAATCATCCCACTCTTTTATCTTTTTAGCTCCTTGTTTAGTCATTCACTAATTTCCATACATGATAACGA
ATTCTTCGGTGATCCCATAGAAGTTGTAGGTCAAAGACAATCATCAATGATGCCTTTTACTTTAGAAGAGCTGATAATGTTGTCTCGATG
CCTTCGAGATGCATGCCTGGGGATCATCAAGTTGGCTTATCCAGAAACCAAGCCAGAAGTTCGAGAAGAATATATTACAGCATTTCAGAG
TATTGGAGTTACTACTAGCTCTGAAATGCAACAATGCATACAGATGGAACAGAAAAGATGGATTCAGTTATTTAAGGTTATCACCAATCT
AGTGAAAATGTTGAAGTCCAGAGACACGAGGAGAAATTTTTGTCCTCCAAACCACTGGCTGTCAGAACAAGAAGATATTAAAGCAGATAA
GGTCACTCAGCTCTATGTGCCAGCATCCAGACATGTGTGGAGGTTCCGGCGGATGGGGAGGATAGGCCCGCTGCAGTCCACCCTGGACGT
GGGTTTGGAGTCCCCGCCGCTGTCTGTGTCTGAGGAAAGACAGCTTGCTGTCCTGACAGAGTTGCCTTTTGTGGTTCCATTTGAGGAACG
AGTAAAGATCTTTCAGAGGTTGATTTATGCAGATAAGCAAGAAGTTCAAGGAGATGGTCCATTTCTGGATGGAATTAATGTCACAATAAG
AAGAAATTACATTTATGAAGATGCTTATGACAAACTTTCTCCAGAAAATGAGCCTGATTTGAAAAAGCGGATCCGTGTGCACTTGCTCAA
TGCCCATGGCCTGGATGAAGCTGGCATTGATGGTGGTGGTATTTTCAGAGAGTTTTTAAATGAACTACTGAAGTCAGGATTTAACCCCAA
CCAGGGGTTCTTTAAGACTACTAATGAAGGGCTTCTGTACCCCAACCCGGCTGCTCAGATGCTTGTGGGAGATTCTTTTGCCAGACATTA
CTACTTCCTAGGCAGAATGCTTGGAAAGGCTCTCTATGAGAACATGCTGGTGGAGCTGCCCTTTGCAGGCTTCTTTCTTTCCAAGTTGCT
TGGAACCAGTGCCGACGTGGACATTCACCACCTCGCCTCCCTAGACCCTGAGGTGTATAAGAATTTGCTCTTTCTGAAGAGCTACGAAGA
CGATGTGGAGGAGCTTGGGCTGAACTTCACTGTGGTGAACAATGACCTGGGAGAGGCGCAGGTAGTTGAACTAAAATTCGGTGGGAAAGA
CATCCCTGTCACCAGCGCCAACCGGATTGCGTACATCCACTTGGTGGCAGACTACAGGCTGAACAGGCAGATCCGCCAGCACTGCCTGGC
TTTCCGCCAGGGCCTTGCCAATGTCGTCAGCCTCGAGTGGCTCCGAATGTTTGATCAGCAAGAAATTCAGGTATTAATTTCTGGTGCACA
AGTTCCCATAAGCCTAGAGGACCTAAAATCCTTTACAAACTATTCAGGAGGCTATTCTGCAGACCATCCTGTTATTAAGGTCTTCTGGAG
AGTTGTGGAAGGGTTCACTGATGAAGAAAAGCGCAAACTGCTGAAGTTTGTAACAAGCTGCTCTCGACCCCCTCTCTTGGGGTTTAAGGA
GTTGTATCCCGCATTTTGTATTCACAACGGAGGCTCCGACCTTGAGCGGCTCCCCACAGCCAGCACCTGCATGAACCTGCTGAAGCTCCC
CGAGTTCTATGACGAGACACTTTTGCGAAGTAAACTTCTCTATGCGATTGAATGTGCCGCTGGCTTTGAGCTGAGCTGAAGCTGATGCTG
GGGTCAGACCCCTACAGAGAACCAGTGCTTCCTTCGTCAGCAGCGCCTCCCCAGACCCACGAGGATACTCACACTGCACGCCTGAGGCTC
TCCTAAGCTCCTTCTTTCATTCTGCCATTCCTCCCTCCCTTCCTTTTTTAAATGATTTTTATTACGGTGTGGTCACTTATTTAGATGGAC
ATTGCTTTTCAAATAACTTAAAATAACACGTTATGTGCCATGTGGCTACTTTAGTAATATTGCCAAGAAGAGCACAGTTTTTACACTAGT
GGCATCTCAGTGAAATTAACCAAAGATGAAGCTTTGGCTTTGCTGGTGAGATCAGAGCCCTCCTGAGCAGGCAGCGCCACTCCAGGGTTC
AGACAGGGCTGCACAGGCGGCAGAGATACAGGGTCTGAGGGCTGAGACGCCATGGGGCCGCTGCTGCTTATGTGGTTGGATTGTTTACAA
GCCTCATTATTAAAACTGAAGGCATTTTTTTTTTCTGCTGCCTTTCCCAAAGTGGTTAGGTTTGGAAAAGAGATGATGATGGTAATATTT
TATTTGTGCTTTTTAAGCCATTTCCCCAAATGGGACTAGCATGCTTGTTTTCAGTATACCGTGGCCTGCCTCATGATGGTTTGGAGATAC
TGTCTGTGGATGTGAGGTGGGGACTTCATTCATTGTCCTATTTCTATCTCCACTTTGTGCCTGGAGAGCTTTCAGGGGAGGTGGAGGAGG
AGGGTCTGCCAAGCTACTGCAACATCTGTCACCCACTATACCCAGTTACTTGGGGGAGGACAGACACTGTGGTGTCATTAAAGTTGTTTG
AACCAAAGTGGCGGCTGCATCTTTGTCCCGATGCTAGCCGTGCCGGTCTCCCATCATCCGCTCGCCCTCCTTTCCCCTGGGCTGCGCCCA
CTTGTCTTCCTGGATATTTGGGGGTGACTCGCCATGCTTGGCACCCTCTGCTTCCTGGTGCTGCTCTGACTCGAAGACGGGACAGTCCCT
GGTGCACATCCAGGGAAGAGGAGTGTCGGTAGTTCTTGCAGTAGGCACTTTATCAGGACCTGACCTGTTGCTGGGTGATTTTAGTCTCTA
CAAACAGAAAGCGTTTCAAAGCGTCAGCTGTGGGAGCAGAGTGACCCTTTGCTGATGCTGGGGGGAGGGGATCTAAATCCTCATTTATCT
CTTCTATGTCTCGTATTTTACTGTCACTGGAGGCTCTGTGGGCTGTCATAGTTAATTGACCATAATTAGCAATATACTTTTAAAGTGGGA
AAGCTGAATGACACTTTTAAGACAATGAACATTATCAAAACAAAATGTATAATTTCTTAATTTGAATAATAAATTAAGCGTTTAAATGCT
ATTTGTAGTCTTGATATACAGAAATAAAATAATTAGGGTTGGTCTTTTTTATTTTAGGTTGTTTTATGTTGAATGTTCTATATCTTATTA
GTTAATTTGTATATTTTATTAGTATTTTGGAAATAGCATATCTGAGACTGAAGAGAAATTGACAATTCACTTATTTGTGGTTTTTTTCTC

>45751_45751_3_LMBR1-UBE3C_LMBR1_chr7_156685622_ENST00000354505_UBE3C_chr7_156979528_ENST00000348165_length(amino acids)=724AA_BP=22
MEGQDEVSAREQHFHSQVRESTEDGRLSVSYITEECLKKLDTKQQTNTLLNLVWRDSASEEVFTTMASVCHTLMVQHRMMVPKVRLLYSL
AFNARFLRHLWFLISSMSTRMITGSMVPLLQVISRGSPMSFEDSSRIIPLFYLFSSLFSHSLISIHDNEFFGDPIEVVGQRQSSMMPFTL
EELIMLSRCLRDACLGIIKLAYPETKPEVREEYITAFQSIGVTTSSEMQQCIQMEQKRWIQLFKVITNLVKMLKSRDTRRNFCPPNHWLS
EQEDIKADKVTQLYVPASRHVWRFRRMGRIGPLQSTLDVGLESPPLSVSEERQLAVLTELPFVVPFEERVKIFQRLIYADKQEVQGDGPF
LDGINVTIRRNYIYEDAYDKLSPENEPDLKKRIRVHLLNAHGLDEAGIDGGGIFREFLNELLKSGFNPNQGFFKTTNEGLLYPNPAAQML
VGDSFARHYYFLGRMLGKALYENMLVELPFAGFFLSKLLGTSADVDIHHLASLDPEVYKNLLFLKSYEDDVEELGLNFTVVNNDLGEAQV
VELKFGGKDIPVTSANRIAYIHLVADYRLNRQIRQHCLAFRQGLANVVSLEWLRMFDQQEIQVLISGAQVPISLEDLKSFTNYSGGYSAD
HPVIKVFWRVVEGFTDEEKRKLLKFVTSCSRPPLLGFKELYPAFCIHNGGSDLERLPTASTCMNLLKLPEFYDETLLRSKLLYAIECAAG

--------------------------------------------------------------
>45751_45751_4_LMBR1-UBE3C_LMBR1_chr7_156685622_ENST00000354505_UBE3C_chr7_156979528_ENST00000389103_length(transcript)=754nt_BP=220nt
GCCGGTGTCGTGGTCGCGGTACCTGTTCCAACACGGCTCGCGGGCCCGTGCCGGCTCCGGTCCCCGGCGCGGCTGTCCGAGCCCCTGCGG
CGGGCGGACGATGGTGTGGCGGAGCACGCGGACGCGGGCGGCGCGGCGGCGGGCATGAAGGAGGATGGAAGGGCAGGACGAGGTGTCGGC
GCGGGAGCAGCACTTCCACAGCCAAGTGCGGGAGTCCACGGAGGATGGCAGACTGTCAGTATCATACATAACAGAGGAATGCCTGAAGAA
GCTGGACACAAAGCAGCAGACCAACACCCTGCTCAACCTGGTGTGGAGGGACTCTGCGAGCGAGGAGGTCTTCACCACCATGGCCTCCGT
CTGCCACACGCTGATGGTGCAGCACCGCATGATGGTACCCAAAGTCAGGGTGTACAAATGAATGTGGAGACCTTTGTACCCTGACATGGA
AAGATTTCCGAGACAGATGCGTACATGAAAACCGGGAAGACACAGGACAGTATGTAGAAGAACCGGCTTTTCCTATAAGAAGGATGGAAA
AAATAGGAATATATATTCATATTGCATAAAGAAACTTGGAAGCATATACAAGAAACTCATGAAAGTGAACACTCGTGTCTGAATATGCCG
AGGAAGCTGGGGCTGGAGCAGAAGTGCTCTTCTGAGTACACTATTTTTATATCACTTTTAAGTTTTGGATTAGGTGAATGACTTAATATT

>45751_45751_4_LMBR1-UBE3C_LMBR1_chr7_156685622_ENST00000354505_UBE3C_chr7_156979528_ENST00000389103_length(amino acids)=165AA_BP=1
MCLPGFHVRICLGNLSMSGYKGLHIHLYTLTLGTIMRCCTISVWQTEAMVVKTSSLAESLHTRLSRVLVCCFVSSFFRHSSVMYDTDSLP

--------------------------------------------------------------
>45751_45751_5_LMBR1-UBE3C_LMBR1_chr7_156685622_ENST00000540390_UBE3C_chr7_156979528_ENST00000348165_length(transcript)=3978nt_BP=252nt
AGAGCTGCTCGTCTGAGGCTGCTGAGGCGACGGCCGGTGTCGTGGTCGCGGTACCTGTTCCAACACGGCTCGCGGGCCCGTGCCGGCTCC
GGTCCCCGGCGCGGCTGTCCGAGCCCCTGCGGCGGGCGGACGATGGTGTGGCGGAGCACGCGGACGCGGGCGGCGCGGCGGCGGGCATGA
AGGAGGATGGAAGGGCAGGACGAGGTGTCGGCGCGGGAGCAGCACTTCCACAGCCAAGTGCGGGAGTCCACGGAGGATGGCAGACTGTCA
GTATCATACATAACAGAGGAATGCCTGAAGAAGCTGGACACAAAGCAGCAGACCAACACCCTGCTCAACCTGGTGTGGAGGGACTCTGCG
AGCGAGGAGGTCTTCACCACCATGGCCTCCGTCTGCCACACGCTGATGGTGCAGCACCGCATGATGGTACCCAAAGTCAGGCTTCTCTAC
AGTTTAGCCTTTAATGCCAGGTTTCTGAGACATCTTTGGTTTCTAATATCTTCCATGTCAACACGGATGATCACAGGGTCTATGGTACCG
TTGCTTCAGGTGATATCCAGGGGTTCTCCTATGTCTTTTGAAGATTCTAGTCGAATCATCCCACTCTTTTATCTTTTTAGCTCCTTGTTT
AGTCATTCACTAATTTCCATACATGATAACGAATTCTTCGGTGATCCCATAGAAGTTGTAGGTCAAAGACAATCATCAATGATGCCTTTT
ACTTTAGAAGAGCTGATAATGTTGTCTCGATGCCTTCGAGATGCATGCCTGGGGATCATCAAGTTGGCTTATCCAGAAACCAAGCCAGAA
GTTCGAGAAGAATATATTACAGCATTTCAGAGTATTGGAGTTACTACTAGCTCTGAAATGCAACAATGCATACAGATGGAACAGAAAAGA
TGGATTCAGTTATTTAAGGTTATCACCAATCTAGTGAAAATGTTGAAGTCCAGAGACACGAGGAGAAATTTTTGTCCTCCAAACCACTGG
CTGTCAGAACAAGAAGATATTAAAGCAGATAAGGTCACTCAGCTCTATGTGCCAGCATCCAGACATGTGTGGAGGTTCCGGCGGATGGGG
AGGATAGGCCCGCTGCAGTCCACCCTGGACGTGGGTTTGGAGTCCCCGCCGCTGTCTGTGTCTGAGGAAAGACAGCTTGCTGTCCTGACA
GAGTTGCCTTTTGTGGTTCCATTTGAGGAACGAGTAAAGATCTTTCAGAGGTTGATTTATGCAGATAAGCAAGAAGTTCAAGGAGATGGT
CCATTTCTGGATGGAATTAATGTCACAATAAGAAGAAATTACATTTATGAAGATGCTTATGACAAACTTTCTCCAGAAAATGAGCCTGAT
TTGAAAAAGCGGATCCGTGTGCACTTGCTCAATGCCCATGGCCTGGATGAAGCTGGCATTGATGGTGGTGGTATTTTCAGAGAGTTTTTA
AATGAACTACTGAAGTCAGGATTTAACCCCAACCAGGGGTTCTTTAAGACTACTAATGAAGGGCTTCTGTACCCCAACCCGGCTGCTCAG
ATGCTTGTGGGAGATTCTTTTGCCAGACATTACTACTTCCTAGGCAGAATGCTTGGAAAGGCTCTCTATGAGAACATGCTGGTGGAGCTG
CCCTTTGCAGGCTTCTTTCTTTCCAAGTTGCTTGGAACCAGTGCCGACGTGGACATTCACCACCTCGCCTCCCTAGACCCTGAGGTGTAT
AAGAATTTGCTCTTTCTGAAGAGCTACGAAGACGATGTGGAGGAGCTTGGGCTGAACTTCACTGTGGTGAACAATGACCTGGGAGAGGCG
CAGGTAGTTGAACTAAAATTCGGTGGGAAAGACATCCCTGTCACCAGCGCCAACCGGATTGCGTACATCCACTTGGTGGCAGACTACAGG
CTGAACAGGCAGATCCGCCAGCACTGCCTGGCTTTCCGCCAGGGCCTTGCCAATGTCGTCAGCCTCGAGTGGCTCCGAATGTTTGATCAG
CAAGAAATTCAGGTATTAATTTCTGGTGCACAAGTTCCCATAAGCCTAGAGGACCTAAAATCCTTTACAAACTATTCAGGAGGCTATTCT
GCAGACCATCCTGTTATTAAGGTCTTCTGGAGAGTTGTGGAAGGGTTCACTGATGAAGAAAAGCGCAAACTGCTGAAGTTTGTAACAAGC
TGCTCTCGACCCCCTCTCTTGGGGTTTAAGGAGTTGTATCCCGCATTTTGTATTCACAACGGAGGCTCCGACCTTGAGCGGCTCCCCACA
GCCAGCACCTGCATGAACCTGCTGAAGCTCCCCGAGTTCTATGACGAGACACTTTTGCGAAGTAAACTTCTCTATGCGATTGAATGTGCC
GCTGGCTTTGAGCTGAGCTGAAGCTGATGCTGGGGTCAGACCCCTACAGAGAACCAGTGCTTCCTTCGTCAGCAGCGCCTCCCCAGACCC
ACGAGGATACTCACACTGCACGCCTGAGGCTCTCCTAAGCTCCTTCTTTCATTCTGCCATTCCTCCCTCCCTTCCTTTTTTAAATGATTT
TTATTACGGTGTGGTCACTTATTTAGATGGACATTGCTTTTCAAATAACTTAAAATAACACGTTATGTGCCATGTGGCTACTTTAGTAAT
ATTGCCAAGAAGAGCACAGTTTTTACACTAGTGGCATCTCAGTGAAATTAACCAAAGATGAAGCTTTGGCTTTGCTGGTGAGATCAGAGC
CCTCCTGAGCAGGCAGCGCCACTCCAGGGTTCAGACAGGGCTGCACAGGCGGCAGAGATACAGGGTCTGAGGGCTGAGACGCCATGGGGC
CGCTGCTGCTTATGTGGTTGGATTGTTTACAAGCCTCATTATTAAAACTGAAGGCATTTTTTTTTTCTGCTGCCTTTCCCAAAGTGGTTA
GGTTTGGAAAAGAGATGATGATGGTAATATTTTATTTGTGCTTTTTAAGCCATTTCCCCAAATGGGACTAGCATGCTTGTTTTCAGTATA
CCGTGGCCTGCCTCATGATGGTTTGGAGATACTGTCTGTGGATGTGAGGTGGGGACTTCATTCATTGTCCTATTTCTATCTCCACTTTGT
GCCTGGAGAGCTTTCAGGGGAGGTGGAGGAGGAGGGTCTGCCAAGCTACTGCAACATCTGTCACCCACTATACCCAGTTACTTGGGGGAG
GACAGACACTGTGGTGTCATTAAAGTTGTTTGAACCAAAGTGGCGGCTGCATCTTTGTCCCGATGCTAGCCGTGCCGGTCTCCCATCATC
CGCTCGCCCTCCTTTCCCCTGGGCTGCGCCCACTTGTCTTCCTGGATATTTGGGGGTGACTCGCCATGCTTGGCACCCTCTGCTTCCTGG
TGCTGCTCTGACTCGAAGACGGGACAGTCCCTGGTGCACATCCAGGGAAGAGGAGTGTCGGTAGTTCTTGCAGTAGGCACTTTATCAGGA
CCTGACCTGTTGCTGGGTGATTTTAGTCTCTACAAACAGAAAGCGTTTCAAAGCGTCAGCTGTGGGAGCAGAGTGACCCTTTGCTGATGC
TGGGGGGAGGGGATCTAAATCCTCATTTATCTCTTCTATGTCTCGTATTTTACTGTCACTGGAGGCTCTGTGGGCTGTCATAGTTAATTG
ACCATAATTAGCAATATACTTTTAAAGTGGGAAAGCTGAATGACACTTTTAAGACAATGAACATTATCAAAACAAAATGTATAATTTCTT
AATTTGAATAATAAATTAAGCGTTTAAATGCTATTTGTAGTCTTGATATACAGAAATAAAATAATTAGGGTTGGTCTTTTTTATTTTAGG
TTGTTTTATGTTGAATGTTCTATATCTTATTAGTTAATTTGTATATTTTATTAGTATTTTGGAAATAGCATATCTGAGACTGAAGAGAAA
TTGACAATTCACTTATTTGTGGTTTTTTTCTCAGCTATTCTGAGCTTATTTATTTATTTGTATGTTCTAATGGCTAAACATTTACATTAA

>45751_45751_5_LMBR1-UBE3C_LMBR1_chr7_156685622_ENST00000540390_UBE3C_chr7_156979528_ENST00000348165_length(amino acids)=724AA_BP=22
MEGQDEVSAREQHFHSQVRESTEDGRLSVSYITEECLKKLDTKQQTNTLLNLVWRDSASEEVFTTMASVCHTLMVQHRMMVPKVRLLYSL
AFNARFLRHLWFLISSMSTRMITGSMVPLLQVISRGSPMSFEDSSRIIPLFYLFSSLFSHSLISIHDNEFFGDPIEVVGQRQSSMMPFTL
EELIMLSRCLRDACLGIIKLAYPETKPEVREEYITAFQSIGVTTSSEMQQCIQMEQKRWIQLFKVITNLVKMLKSRDTRRNFCPPNHWLS
EQEDIKADKVTQLYVPASRHVWRFRRMGRIGPLQSTLDVGLESPPLSVSEERQLAVLTELPFVVPFEERVKIFQRLIYADKQEVQGDGPF
LDGINVTIRRNYIYEDAYDKLSPENEPDLKKRIRVHLLNAHGLDEAGIDGGGIFREFLNELLKSGFNPNQGFFKTTNEGLLYPNPAAQML
VGDSFARHYYFLGRMLGKALYENMLVELPFAGFFLSKLLGTSADVDIHHLASLDPEVYKNLLFLKSYEDDVEELGLNFTVVNNDLGEAQV
VELKFGGKDIPVTSANRIAYIHLVADYRLNRQIRQHCLAFRQGLANVVSLEWLRMFDQQEIQVLISGAQVPISLEDLKSFTNYSGGYSAD
HPVIKVFWRVVEGFTDEEKRKLLKFVTSCSRPPLLGFKELYPAFCIHNGGSDLERLPTASTCMNLLKLPEFYDETLLRSKLLYAIECAAG

--------------------------------------------------------------
>45751_45751_6_LMBR1-UBE3C_LMBR1_chr7_156685622_ENST00000540390_UBE3C_chr7_156979528_ENST00000389103_length(transcript)=786nt_BP=252nt
AGAGCTGCTCGTCTGAGGCTGCTGAGGCGACGGCCGGTGTCGTGGTCGCGGTACCTGTTCCAACACGGCTCGCGGGCCCGTGCCGGCTCC
GGTCCCCGGCGCGGCTGTCCGAGCCCCTGCGGCGGGCGGACGATGGTGTGGCGGAGCACGCGGACGCGGGCGGCGCGGCGGCGGGCATGA
AGGAGGATGGAAGGGCAGGACGAGGTGTCGGCGCGGGAGCAGCACTTCCACAGCCAAGTGCGGGAGTCCACGGAGGATGGCAGACTGTCA
GTATCATACATAACAGAGGAATGCCTGAAGAAGCTGGACACAAAGCAGCAGACCAACACCCTGCTCAACCTGGTGTGGAGGGACTCTGCG
AGCGAGGAGGTCTTCACCACCATGGCCTCCGTCTGCCACACGCTGATGGTGCAGCACCGCATGATGGTACCCAAAGTCAGGGTGTACAAA
TGAATGTGGAGACCTTTGTACCCTGACATGGAAAGATTTCCGAGACAGATGCGTACATGAAAACCGGGAAGACACAGGACAGTATGTAGA
AGAACCGGCTTTTCCTATAAGAAGGATGGAAAAAATAGGAATATATATTCATATTGCATAAAGAAACTTGGAAGCATATACAAGAAACTC
ATGAAAGTGAACACTCGTGTCTGAATATGCCGAGGAAGCTGGGGCTGGAGCAGAAGTGCTCTTCTGAGTACACTATTTTTATATCACTTT

>45751_45751_6_LMBR1-UBE3C_LMBR1_chr7_156685622_ENST00000540390_UBE3C_chr7_156979528_ENST00000389103_length(amino acids)=175AA_BP=1
MCLPGFHVRICLGNLSMSGYKGLHIHLYTLTLGTIMRCCTISVWQTEAMVVKTSSLAESLHTRLSRVLVCCFVSSFFRHSSVMYDTDSLP

--------------------------------------------------------------

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Fusion Gene PPI Analysis for LMBR1-UBE3C


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for LMBR1-UBE3C


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for LMBR1-UBE3C


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource