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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:LMCD1-ZNF589 (FusionGDB2 ID:45771)

Fusion Gene Summary for LMCD1-ZNF589

Fusion gene summary

Fusion gene information	Fusion gene name: LMCD1-ZNF589
	Fusion gene ID: 45771
		Hgene	Tgene
	Gene symbol	LMCD1	ZNF589
	Gene ID	29995	51385
	Gene name	LIM and cysteine rich domains 1	zinc finger protein 589
	Synonyms	-	SZF1
	Cytomap	3p25.3	3p21.31
	Type of gene	protein-coding	protein-coding
	Description	LIM and cysteine-rich domains protein 1dyxin	zinc finger protein 589KRAB-zinc finger protein SZF1-1stem cell zinc finger protein 1
	Modification date	20200313	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000157600, ENST00000535732, ENST00000397386, ENST00000454244,	ENST00000454212, ENST00000354698, ENST00000412564, ENST00000427617, ENST00000440261,
Fusion gene scores	* DoF score	2 X 2 X 2=8	5 X 4 X 3=60
	# samples	2	5
	** MAII score	log2(2/8*10)=1.32192809488736	log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: LMCD1 [Title/Abstract] AND ZNF589 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	LMCD1(8543666)-ZNF589(48302303), # samples:3
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	ZNF589	GO:0000122	negative regulation of transcription by RNA polymerase II	12097288

Fusion gene breakpoints across LMCD1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ZNF589 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	PRAD	TCGA-KK-A7B1-01A	LMCD1	chr3	8543666	-	ZNF589	chr3	48302303	+
ChimerDB4	PRAD	TCGA-KK-A7B1-01A	LMCD1	chr3	8543666	+	ZNF589	chr3	48302303	+
ChimerDB4	PRAD	TCGA-KK-A7B1	LMCD1	chr3	8543666	+	ZNF589	chr3	48302303	+

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Fusion Gene ORF analysis for LMCD1-ZNF589

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-3UTR	ENST00000157600	ENST00000454212	LMCD1	chr3	8543666	+	ZNF589	chr3	48302303	+
5CDS-3UTR	ENST00000535732	ENST00000454212	LMCD1	chr3	8543666	+	ZNF589	chr3	48302303	+
5UTR-3CDS	ENST00000397386	ENST00000354698	LMCD1	chr3	8543666	+	ZNF589	chr3	48302303	+
5UTR-3CDS	ENST00000397386	ENST00000412564	LMCD1	chr3	8543666	+	ZNF589	chr3	48302303	+
5UTR-3CDS	ENST00000397386	ENST00000427617	LMCD1	chr3	8543666	+	ZNF589	chr3	48302303	+
5UTR-3CDS	ENST00000397386	ENST00000440261	LMCD1	chr3	8543666	+	ZNF589	chr3	48302303	+
5UTR-3CDS	ENST00000454244	ENST00000354698	LMCD1	chr3	8543666	+	ZNF589	chr3	48302303	+
5UTR-3CDS	ENST00000454244	ENST00000412564	LMCD1	chr3	8543666	+	ZNF589	chr3	48302303	+
5UTR-3CDS	ENST00000454244	ENST00000427617	LMCD1	chr3	8543666	+	ZNF589	chr3	48302303	+
5UTR-3CDS	ENST00000454244	ENST00000440261	LMCD1	chr3	8543666	+	ZNF589	chr3	48302303	+
5UTR-3UTR	ENST00000397386	ENST00000454212	LMCD1	chr3	8543666	+	ZNF589	chr3	48302303	+
5UTR-3UTR	ENST00000454244	ENST00000454212	LMCD1	chr3	8543666	+	ZNF589	chr3	48302303	+
In-frame	ENST00000157600	ENST00000354698	LMCD1	chr3	8543666	+	ZNF589	chr3	48302303	+
In-frame	ENST00000157600	ENST00000412564	LMCD1	chr3	8543666	+	ZNF589	chr3	48302303	+
In-frame	ENST00000157600	ENST00000427617	LMCD1	chr3	8543666	+	ZNF589	chr3	48302303	+
In-frame	ENST00000157600	ENST00000440261	LMCD1	chr3	8543666	+	ZNF589	chr3	48302303	+
In-frame	ENST00000535732	ENST00000354698	LMCD1	chr3	8543666	+	ZNF589	chr3	48302303	+
In-frame	ENST00000535732	ENST00000412564	LMCD1	chr3	8543666	+	ZNF589	chr3	48302303	+
In-frame	ENST00000535732	ENST00000427617	LMCD1	chr3	8543666	+	ZNF589	chr3	48302303	+
In-frame	ENST00000535732	ENST00000440261	LMCD1	chr3	8543666	+	ZNF589	chr3	48302303	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000157600	LMCD1	chr3	8543666	+	ENST00000354698	ZNF589	chr3	48302303	+	3474	274	13	1272	419
ENST00000157600	LMCD1	chr3	8543666	+	ENST00000427617	ZNF589	chr3	48302303	+	1783	274	13	468	151
ENST00000157600	LMCD1	chr3	8543666	+	ENST00000412564	ZNF589	chr3	48302303	+	700	274	13	420	135
ENST00000157600	LMCD1	chr3	8543666	+	ENST00000440261	ZNF589	chr3	48302303	+	1029	274	13	711	232
ENST00000535732	LMCD1	chr3	8543666	+	ENST00000354698	ZNF589	chr3	48302303	+	3356	156	27	1154	375
ENST00000535732	LMCD1	chr3	8543666	+	ENST00000427617	ZNF589	chr3	48302303	+	1665	156	777	436	113
ENST00000535732	LMCD1	chr3	8543666	+	ENST00000412564	ZNF589	chr3	48302303	+	582	156	27	302	91
ENST00000535732	LMCD1	chr3	8543666	+	ENST00000440261	ZNF589	chr3	48302303	+	911	156	27	593	188

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000157600	ENST00000354698	LMCD1	chr3	8543666	+	ZNF589	chr3	48302303	+	0.022410743	0.9775892
ENST00000157600	ENST00000427617	LMCD1	chr3	8543666	+	ZNF589	chr3	48302303	+	0.19789597	0.80210406
ENST00000157600	ENST00000412564	LMCD1	chr3	8543666	+	ZNF589	chr3	48302303	+	0.3745124	0.62548757
ENST00000157600	ENST00000440261	LMCD1	chr3	8543666	+	ZNF589	chr3	48302303	+	0.021379787	0.9786202
ENST00000535732	ENST00000354698	LMCD1	chr3	8543666	+	ZNF589	chr3	48302303	+	0.016662313	0.9833377
ENST00000535732	ENST00000427617	LMCD1	chr3	8543666	+	ZNF589	chr3	48302303	+	0.18597122	0.8140288
ENST00000535732	ENST00000412564	LMCD1	chr3	8543666	+	ZNF589	chr3	48302303	+	0.220479	0.779521
ENST00000535732	ENST00000440261	LMCD1	chr3	8543666	+	ZNF589	chr3	48302303	+	0.015332301	0.9846677

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Fusion Genomic Features for LMCD1-ZNF589

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
LMCD1	chr3	8543666	+	ZNF589	chr3	48302302	+	9.97E-05	0.99990034
LMCD1	chr3	8543666	+	ZNF589	chr3	48302302	+	9.97E-05	0.99990034
LMCD1	chr3	8543666	+	ZNF589	chr3	48302302	+	9.97E-05	0.99990034
LMCD1	chr3	8543666	+	ZNF589	chr3	48302302	+	9.97E-05	0.99990034

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for LMCD1-ZNF589

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:8543666/chr3:48302303)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

ZNF589

chr3:8543666

chr3:48302303

ENST00000354698

35_108

365.0

Domain

KRAB

Tgene

ZNF589

chr3:8543666

chr3:48302303

ENST00000354698

248_270

365.0

Zinc finger

C2H2-type 1

Tgene

ZNF589

chr3:8543666

chr3:48302303

ENST00000354698

276_298

365.0

Zinc finger

C2H2-type 2

Tgene

ZNF589

chr3:8543666

chr3:48302303

ENST00000354698

304_326

365.0

Zinc finger

C2H2-type 3

Tgene

ZNF589

chr3:8543666

chr3:48302303

ENST00000354698

332_354

365.0

Zinc finger

C2H2-type 4

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

LMCD1

chr3:8543666

chr3:48302303

ENST00000157600

28_58

366.0

Compositional bias

Note=Cys-rich

Hgene

LMCD1

chr3:8543666

chr3:48302303

ENST00000157600

241_306

366.0

Domain

LIM zinc-binding 1

Hgene

LMCD1

chr3:8543666

chr3:48302303

ENST00000157600

307_365

366.0

Domain

LIM zinc-binding 2

Hgene

LMCD1

chr3:8543666

chr3:48302303

ENST00000157600

99_206

366.0

Domain

PET

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Fusion Gene Sequence for LMCD1-ZNF589

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>45771_45771_1_LMCD1-ZNF589_LMCD1_chr3_8543666_ENST00000157600_ZNF589_chr3_48302303_ENST00000354698_length(transcript)=3474nt_BP=274nt
GGACAGCCTCGCGCTGGGATTGGCTGGCCTCGCGCGAGCGCCGGCGCGGAGTGGCTGGCGAGGTTTTAGAGGGAGTCCCGCTCTCCAATT
AAAGCGGCCCAGCTGCGCCTGGCTGCGCACAGAGCTCCCTCCCAGGCCCGCGAACTTGGCCATTCAGCCGCCGCTGTCCCCGCTGCGCGC
CCTCGCGCCTCTGCCTGAGAAGCCAGGCGCTGTTCCCCCACCCCAGAAGAGGATGGCAAAGGTGGCTAAGGACCTCAACCCAGGAGTTAA
AAAGGGACCAGTGACTTTCGAGGATGTGGCTGTGCTTTTCACTGAGGCAGAGTGGAAGAGACTGAGCCTTGAGCAGAGGAACCTATACAA
AGAAGTGATGCTGGAAAATCTCAGGAATCTGGTCTCATTGGCAGAATCAAAGCCAGAAGTCCATACCTGCCCTTCTTGCCCTCTGGCCTT
TGGCAGTCAGCAGTTCCTCAGCCAAGATGAGCTACACAATCATCCTATTCCAGGTTTCCATGCAGGAAATCAACTCCACCCAGGAAATCC
CTGCCCAGAGGATCAGCCACAGTCACAACATCCTTCTGATAAAAATCACAGGGGGGCTGAAGCAGAAGATCAACGAGTGGAAGGAGGCGT
CAGACCCTTGTTTTGGAGTACAAATGAAAGGGGGGCTTTAGTGGGTTTCTCTAGCCTGTTCCAGAGACCACCAATAAGCTCTTGGGGAGG
CAACAGAATATTAGAGATACAGCTCAGTCCAGCCCAGAATGCAAGCTCTGAGGAAGTAGACAGAATTTCCAAGAGGGCAGAAACCCCAGG
GTTTGGAGCAGTCACGTTTGGGGAGTGTGCACTAGCTTTTAACCAGAAGTCAAACCTGTTCAGACAGAAGGCAGTCACAGCAGAAAAATC
TTCAGACAAAAGGCAGTCACAGGTGTGCAGGGAGTGTGGGCGAGGCTTTAGCAGGAAGTCACAGCTCATCATACACCAGAGGACACACAC
AGGAGAAAAGCCTTATGTCTGCGGAGAGTGTGGGCGAGGCTTTATAGTTGAGTCAGTCCTCCGCAACCACCTGAGTACACACTCCGGGGA
GAAACCTTATGTGTGCAGCCATTGTGGGCGAGGCTTTAGCTGCAAGCCATACCTCATCAGACATCAGAGGACACACACAAGGGAGAAATC
GTTTATGTGCACAGTGTGTGGGCGAGGCTTTCGTGAAAAGTCAGAGCTCATTAAGCACCAGAGAATTCACACGGGGGATAAGCCTTATGT
GTGCAGAGATTGAGGCCGAGGCTTTGTAAGGAGATCATGTCTCAACACACACCAGAGGATACATTCAGATGAGAAGCCTTTTGTTTGCAG
AGAGTGTGGGCGAGGCTTTCGTGCTAAATCAACTCTCCTCCTACACCAGTGGACACATTCAGAGGTGAAACCTCACGTGTGTGAGGAGTG
TGGGCATGGATTTAGCCAGAAGTCGTCGCTCAAATCACATCGGAGAACACACTCAGGGGAGAAGCCTTATGTGTGTGGGGAATGTGGGCG
GGGATTTAGCCGGAGGATAGTCCTCAATGGACACTGGAGGACACACACGGGAGAGAAGCCTTACACGTGCTTTGAGTGTGGGCGAAACTT
TAGCCTCAAGTCCGCTCTTAGTGTACATCAGAGGATACACTCTGGGGAGAAGCCTTATGCATGCACGGAGTGTGGGCAAGGCTTTATCAC
GAAATCACAGCTCATCAGACACCAGAGGACACACACAGGAGAAAAGCCTTATGTCTGCGGAGAGTGTGGGCGAGGCTTTATAGCTCAGTC
AACCCTCCACTACCACCGGAGTACACACTCCAAGGAAAAACCTTATGTGTGCAGCCAGTGTGGGCGAGGCTTTTGTGATAAATCAACTCT
CCTCGCACACGAGCAGACACATTCAGGGGAGAAGCCTTATGTGTGTGGGGAATGTGGGCGGGGATTTGGCCGGAAGATACTCCTCAACAG
ACACTGGAGGACACACACAGGAGAGAAACCTTACGCATGCATCGAGTGTGGGCGAAACTTTAGCCACAAGTCCACTCTCAGCTTACATCA
GAGGATACACTCGGGGGAGAAGCCTTATGCATGCGTGGAGTGTGGGCAAAGCTTTAGGAGAAAGTCACAGCTCATCATACACCAGAAGAT
ACACTCGGGGAAAAGCTTTAGAGGTGCAAGGAGTGAGGATGTGATTTTAGCAACAAGTCAGCCATCAGCCACACCAGCGGAAATGCTTAG
GGAGAAGCCTTGTTTGTAAGGTAATGTGGACAGAGCTGTACGTGGACATCATTACTTGTCACGTGTCAGAGGACACACTCGGGAGAAACC
TTCATGGAGTGAGAGTAAGGTGTTGGCTGGAAGTGGCCCCTTAAGAGATACTTGGAGTCAAATCTATCCACTGTACGCCCACCCCACTCT
TGTTCTAAGAGCTTTGGGGACAGTCTTTTGACCCCTTACATTCCTTTAGATGTGAAGATGACAGAGATCTAACTTCTGAGAGCAGAGGTG
TCAAGTGACGGTCCCCTTGGAGGAATGGTCTTTGCATCTGACTACTTCCTTCTGCAACTGTGTTCTTCCATTAGCTTCCATGACACTCTC
CTGCTTTATTTTTTTCTACATCTCTAGCCTTTGCTGTTTCCTCTCCTACCCCACCTTTAGATTTTACTCAGAGTTCAGTCTCCAGCCCTA
CAATCTGAGGGACACCTTTACCAGGTCCCCTTCCTAACCCTCCAGTCCCAAATCCAAGATTCTTTAACCACACTCTAAAAGTTCTTCAGA
CTCAGGACTTAAACATAGCCACGCCACCTTGGCCTTCAATGACAGGGATCTAGCAATGCTGCATCATCAGCCTTCCAATACCAGGTTTAA
GGGTATTTTAAACACAGCTCCTCTTAAATCCTCCAATCTCAGTACCCAGTGTTTTAGCCATGCTCGGGTGGCTAAATTACATCCAGGAAT
GGTGCCAGGGCCTTTAGCCATTTGTCTCTCCTCACACTCCAGGGCCCATATGGCCCAGGTTCTGACAGTTTGCCTTACTCCCTTGGGCTG
GGGCTAGCCCTACCTGATACCCTGTGTCAATGAGTGTACCTTGGAGAGCTATCCACTCAGGCCCCAGTGCCTCTATTTGCTAAGGGACTC
TGCCACAGAAAAGAAGGGGAGAGATGTTCATGTAACCTCAAAATACTTAGGCTTGGTTTTGATGCTAGAGAGGAAAAAGGACTTGGAGAG
AGAGAAGGAATGGCTGGTCCAGAGGCTTTTGTCCACTCCCTCTCACTGGAAGTGGTTGATCTCCAGGGAATCCCCAAGGTTAGCCTGCTT
AGGGGAAGGGCTAGGGGTACCTGGAATGTAGGATCTCCCCCATGCCTGGCCTACCACCCTAATGTGTCTGGAATTGGTGGGTTCTTGGTC

>45771_45771_1_LMCD1-ZNF589_LMCD1_chr3_8543666_ENST00000157600_ZNF589_chr3_48302303_ENST00000354698_length(amino acids)=419AA_BP=87
MGLAGLARAPARSGWRGFRGSPALQLKRPSCAWLRTELPPRPANLAIQPPLSPLRALAPLPEKPGAVPPPQKRMAKVAKDLNPGVKKGPV
TFEDVAVLFTEAEWKRLSLEQRNLYKEVMLENLRNLVSLAESKPEVHTCPSCPLAFGSQQFLSQDELHNHPIPGFHAGNQLHPGNPCPED
QPQSQHPSDKNHRGAEAEDQRVEGGVRPLFWSTNERGALVGFSSLFQRPPISSWGGNRILEIQLSPAQNASSEEVDRISKRAETPGFGAV
TFGECALAFNQKSNLFRQKAVTAEKSSDKRQSQVCRECGRGFSRKSQLIIHQRTHTGEKPYVCGECGRGFIVESVLRNHLSTHSGEKPYV

--------------------------------------------------------------
>45771_45771_2_LMCD1-ZNF589_LMCD1_chr3_8543666_ENST00000157600_ZNF589_chr3_48302303_ENST00000412564_length(transcript)=700nt_BP=274nt
GGACAGCCTCGCGCTGGGATTGGCTGGCCTCGCGCGAGCGCCGGCGCGGAGTGGCTGGCGAGGTTTTAGAGGGAGTCCCGCTCTCCAATT
AAAGCGGCCCAGCTGCGCCTGGCTGCGCACAGAGCTCCCTCCCAGGCCCGCGAACTTGGCCATTCAGCCGCCGCTGTCCCCGCTGCGCGC
CCTCGCGCCTCTGCCTGAGAAGCCAGGCGCTGTTCCCCCACCCCAGAAGAGGATGGCAAAGGTGGCTAAGGACCTCAACCCAGGAGTTAA
AAAGGGACCAGTGACTTTCGAGGATGTGGCTGTGCTTTTCACTGAGGCAGAGTGGAAGAGACTGAGCCTTGAGCAGAGGAACCTATACAA
AGAAGTGATGCTGGAAAATCTCAGGAATCTGGTCTCATTGGTGCTCTCCTATCAAATCTAGAATTGGAAGATTGATGGACAGCAACTGAG
GTGCTACCAGGATACCAAAAAGTCTGCTGGATAAACACCATCTCTATTCTAATATTATGGAGAGATCAGGATCTCCTGTGCCCAAATCAA
ACCTGTTAATACACTCAGCTGTCCTCAGTGGTAACACTGAGGTCAACACACAACTCCAACATCAGGAACAAGTCATAACCATTTTGCATC

>45771_45771_2_LMCD1-ZNF589_LMCD1_chr3_8543666_ENST00000157600_ZNF589_chr3_48302303_ENST00000412564_length(amino acids)=135AA_BP=87
MGLAGLARAPARSGWRGFRGSPALQLKRPSCAWLRTELPPRPANLAIQPPLSPLRALAPLPEKPGAVPPPQKRMAKVAKDLNPGVKKGPV

--------------------------------------------------------------
>45771_45771_3_LMCD1-ZNF589_LMCD1_chr3_8543666_ENST00000157600_ZNF589_chr3_48302303_ENST00000427617_length(transcript)=1783nt_BP=274nt
GGACAGCCTCGCGCTGGGATTGGCTGGCCTCGCGCGAGCGCCGGCGCGGAGTGGCTGGCGAGGTTTTAGAGGGAGTCCCGCTCTCCAATT
AAAGCGGCCCAGCTGCGCCTGGCTGCGCACAGAGCTCCCTCCCAGGCCCGCGAACTTGGCCATTCAGCCGCCGCTGTCCCCGCTGCGCGC
CCTCGCGCCTCTGCCTGAGAAGCCAGGCGCTGTTCCCCCACCCCAGAAGAGGATGGCAAAGGTGGCTAAGGACCTCAACCCAGGAGTTAA
AAAGGGACCAGTGACTTTCGAGGATGTGGCTGTGCTTTTCACTGAGGCAGAGTGGAAGAGACTGAGCCTTGAGCAGAGGAACCTATACAA
AGAAGTGATGCTGGAAAATCTCAGGAATCTGGTCTCATTGGTTCTGGAACTGGGAAGTCCAAGATCAGGGCTCCTGCCCCTGGACCTGAA
CCTGGATCTTTGGCTTTGATGTTGGACCTTGTGTGTGGATATGAACTTTGAACCTGCACCTTGGAACTAAACCTCTGACTTGGATTTGTT
CTGCATTTTGGAACTCACCTTAGACCTGAACCTTGGTCATGAAATGGATCTGAATCATTCTTGGGTCTTGGACATGGGACTTGGACCTCC
ATGTGTATCTTGGACTTAGGACCATGATCTGGACCTTGTAAATTGACTTGGACTTTGGACTTGGACCTTGGACTAGAATTTGTCCCTGGC
TGTGGACCTCGTCTTTGGATCTGGATCTGGACCTGGTCTTGGATGTTGGACCTAGATGCAGGCCTTGATTTGATTTGGAACATGGACTTG
GTCCTTGCACATGGCCCAACACCCGCGTCTTTGGAACTGCATCTTGGACCTTGGATCTGAAATTTAAACAGGGAGGTGACCTTCATTTCT
TGTATTTGACTTTATAACTGGAAATTCAATCTCTACCTGGATCTTGGACCTGGATCTCAGACCTTGCTTTTTATTGGGCCATGGATCTTA
TACCTTAAACATGGAAATTGTACCTGGATTTGGACCTTTGACTTGGACCTGGATCTGGACCCAGGGATAAGATTTGGACCTCACTTGCAA
ATTTTGGTAATGAAATTTTCCTTTGCTCCTGTAGTCCTTGGACCTAGGCTTCAGTCATGGATTTAGACCTTAGACGTGACCATCAGACCT
TAGAGTTGAACCTAAATTCCTGGTCCCCAGTCCTATAACTCAGAATGATTATGCATAACCTTGGACTTAGAACTTAGATCTGGATCTTAG
AGCTGATACTTGACCTGGTACTGGATATTTAACCTTGGACTTCAGACATGGATTTAATCTGGGCCTTGGGATGATTTAAGATCTAGAAGT
GGACCTAGAATTAGACCTTGGACTTATGTGCCTGAGCCTGGACTTTGGAAGTGGACTTTGGGCCTTGTAACTCAACCTTGAATATGAGCC
TCAAATGTAGACTGTGGGCCAGGCACAGTGGCTCACATCTGTAATCCCAGCACTTTGGGTGGAAAGCTGAGGCAGGTGGATCACTTGAGC
TCAGGAATTCAAGACCAGCCTGGGGAACATGGTGAAAACCTGGCTCTACAAAAAATAAAAAAATTAGCCAGGCTTGGTGGCACACACCTG
TAGTTCCAGGTACTCAGGAGGCTGAGGCAGGAGGTTCACTTGGGCCCAGGAGGCAGAGGTTGCAGTGAGCTGAGCTTGTACAGCTGCACT

>45771_45771_3_LMCD1-ZNF589_LMCD1_chr3_8543666_ENST00000157600_ZNF589_chr3_48302303_ENST00000427617_length(amino acids)=151AA_BP=87
MGLAGLARAPARSGWRGFRGSPALQLKRPSCAWLRTELPPRPANLAIQPPLSPLRALAPLPEKPGAVPPPQKRMAKVAKDLNPGVKKGPV

--------------------------------------------------------------
>45771_45771_4_LMCD1-ZNF589_LMCD1_chr3_8543666_ENST00000157600_ZNF589_chr3_48302303_ENST00000440261_length(transcript)=1029nt_BP=274nt
GGACAGCCTCGCGCTGGGATTGGCTGGCCTCGCGCGAGCGCCGGCGCGGAGTGGCTGGCGAGGTTTTAGAGGGAGTCCCGCTCTCCAATT
AAAGCGGCCCAGCTGCGCCTGGCTGCGCACAGAGCTCCCTCCCAGGCCCGCGAACTTGGCCATTCAGCCGCCGCTGTCCCCGCTGCGCGC
CCTCGCGCCTCTGCCTGAGAAGCCAGGCGCTGTTCCCCCACCCCAGAAGAGGATGGCAAAGGTGGCTAAGGACCTCAACCCAGGAGTTAA
AAAGGGACCAGTGACTTTCGAGGATGTGGCTGTGCTTTTCACTGAGGCAGAGTGGAAGAGACTGAGCCTTGAGCAGAGGAACCTATACAA
AGAAGTGATGCTGGAAAATCTCAGGAATCTGGTCTCATTGGAATCAAAGCCAGAAGTCCATACCTGCCCTTCTTGCCCTCTGGCCTTTGG
CAGTCAGCAGTTCCTCAGCCAAGATGAGCTACACAATCATCCTATTCCAGGTTTCCATGCAGGAAATCAACTCCACCCAGGAAATCCCTG
CCCAGAGGATCAGCCACAGTCACAACATCCTTCTGATAAAAATCACAGGGGGGCTGAAGCAGAAGATCAACGAGTGGAAGGAGGCGTCAG
ACCCTTGTTTTGGATTCTGGAACTGGGAAGTCCAAGATCAGGGCTCCTGCCCCTGGACCTGAACCTGGATCTTTGGCTTTGATGTTGGAC
CTTGTGTGTGGATATGAACTTTGAACCTGCACCTTGGAACTAAACCTCTGACTTGGATTTGTTCTGCATTTTGGAACTCACCTTAGACCT
GAACCTTGGTCATGAAATGGATCTGAATCATTCTTGGGTCTTGGACATGGGACTTGGACCTCCATGTGTATCTTGGACTTAGGACCATGA
TCTGGACCTTGTAAATTGACTTGGACTTTGGACTTGGACCTTGGACTAGAATTTGTCCCTGGCTGTGGACCTCGTCTTTGGATCTGGATC

>45771_45771_4_LMCD1-ZNF589_LMCD1_chr3_8543666_ENST00000157600_ZNF589_chr3_48302303_ENST00000440261_length(amino acids)=232AA_BP=87
MGLAGLARAPARSGWRGFRGSPALQLKRPSCAWLRTELPPRPANLAIQPPLSPLRALAPLPEKPGAVPPPQKRMAKVAKDLNPGVKKGPV
TFEDVAVLFTEAEWKRLSLEQRNLYKEVMLENLRNLVSLESKPEVHTCPSCPLAFGSQQFLSQDELHNHPIPGFHAGNQLHPGNPCPEDQ

--------------------------------------------------------------
>45771_45771_5_LMCD1-ZNF589_LMCD1_chr3_8543666_ENST00000535732_ZNF589_chr3_48302303_ENST00000354698_length(transcript)=3356nt_BP=156nt
ACAGAGCTCCCTCCCAGGCCCGCGAACTTGGCCATTCAGCCGCCGCTGTCCCCGCTGCGCGCCCTCGCGCCTCTGCCTGAGAAGCCAGGC
GCTGTTCCCCCACCCCAGAAGAGGATGGCAAAGGTGGCTAAGGACCTCAACCCAGGAGTTAAAAAGGGACCAGTGACTTTCGAGGATGTG
GCTGTGCTTTTCACTGAGGCAGAGTGGAAGAGACTGAGCCTTGAGCAGAGGAACCTATACAAAGAAGTGATGCTGGAAAATCTCAGGAAT
CTGGTCTCATTGGCAGAATCAAAGCCAGAAGTCCATACCTGCCCTTCTTGCCCTCTGGCCTTTGGCAGTCAGCAGTTCCTCAGCCAAGAT
GAGCTACACAATCATCCTATTCCAGGTTTCCATGCAGGAAATCAACTCCACCCAGGAAATCCCTGCCCAGAGGATCAGCCACAGTCACAA
CATCCTTCTGATAAAAATCACAGGGGGGCTGAAGCAGAAGATCAACGAGTGGAAGGAGGCGTCAGACCCTTGTTTTGGAGTACAAATGAA
AGGGGGGCTTTAGTGGGTTTCTCTAGCCTGTTCCAGAGACCACCAATAAGCTCTTGGGGAGGCAACAGAATATTAGAGATACAGCTCAGT
CCAGCCCAGAATGCAAGCTCTGAGGAAGTAGACAGAATTTCCAAGAGGGCAGAAACCCCAGGGTTTGGAGCAGTCACGTTTGGGGAGTGT
GCACTAGCTTTTAACCAGAAGTCAAACCTGTTCAGACAGAAGGCAGTCACAGCAGAAAAATCTTCAGACAAAAGGCAGTCACAGGTGTGC
AGGGAGTGTGGGCGAGGCTTTAGCAGGAAGTCACAGCTCATCATACACCAGAGGACACACACAGGAGAAAAGCCTTATGTCTGCGGAGAG
TGTGGGCGAGGCTTTATAGTTGAGTCAGTCCTCCGCAACCACCTGAGTACACACTCCGGGGAGAAACCTTATGTGTGCAGCCATTGTGGG
CGAGGCTTTAGCTGCAAGCCATACCTCATCAGACATCAGAGGACACACACAAGGGAGAAATCGTTTATGTGCACAGTGTGTGGGCGAGGC
TTTCGTGAAAAGTCAGAGCTCATTAAGCACCAGAGAATTCACACGGGGGATAAGCCTTATGTGTGCAGAGATTGAGGCCGAGGCTTTGTA
AGGAGATCATGTCTCAACACACACCAGAGGATACATTCAGATGAGAAGCCTTTTGTTTGCAGAGAGTGTGGGCGAGGCTTTCGTGCTAAA
TCAACTCTCCTCCTACACCAGTGGACACATTCAGAGGTGAAACCTCACGTGTGTGAGGAGTGTGGGCATGGATTTAGCCAGAAGTCGTCG
CTCAAATCACATCGGAGAACACACTCAGGGGAGAAGCCTTATGTGTGTGGGGAATGTGGGCGGGGATTTAGCCGGAGGATAGTCCTCAAT
GGACACTGGAGGACACACACGGGAGAGAAGCCTTACACGTGCTTTGAGTGTGGGCGAAACTTTAGCCTCAAGTCCGCTCTTAGTGTACAT
CAGAGGATACACTCTGGGGAGAAGCCTTATGCATGCACGGAGTGTGGGCAAGGCTTTATCACGAAATCACAGCTCATCAGACACCAGAGG
ACACACACAGGAGAAAAGCCTTATGTCTGCGGAGAGTGTGGGCGAGGCTTTATAGCTCAGTCAACCCTCCACTACCACCGGAGTACACAC
TCCAAGGAAAAACCTTATGTGTGCAGCCAGTGTGGGCGAGGCTTTTGTGATAAATCAACTCTCCTCGCACACGAGCAGACACATTCAGGG
GAGAAGCCTTATGTGTGTGGGGAATGTGGGCGGGGATTTGGCCGGAAGATACTCCTCAACAGACACTGGAGGACACACACAGGAGAGAAA
CCTTACGCATGCATCGAGTGTGGGCGAAACTTTAGCCACAAGTCCACTCTCAGCTTACATCAGAGGATACACTCGGGGGAGAAGCCTTAT
GCATGCGTGGAGTGTGGGCAAAGCTTTAGGAGAAAGTCACAGCTCATCATACACCAGAAGATACACTCGGGGAAAAGCTTTAGAGGTGCA
AGGAGTGAGGATGTGATTTTAGCAACAAGTCAGCCATCAGCCACACCAGCGGAAATGCTTAGGGAGAAGCCTTGTTTGTAAGGTAATGTG
GACAGAGCTGTACGTGGACATCATTACTTGTCACGTGTCAGAGGACACACTCGGGAGAAACCTTCATGGAGTGAGAGTAAGGTGTTGGCT
GGAAGTGGCCCCTTAAGAGATACTTGGAGTCAAATCTATCCACTGTACGCCCACCCCACTCTTGTTCTAAGAGCTTTGGGGACAGTCTTT
TGACCCCTTACATTCCTTTAGATGTGAAGATGACAGAGATCTAACTTCTGAGAGCAGAGGTGTCAAGTGACGGTCCCCTTGGAGGAATGG
TCTTTGCATCTGACTACTTCCTTCTGCAACTGTGTTCTTCCATTAGCTTCCATGACACTCTCCTGCTTTATTTTTTTCTACATCTCTAGC
CTTTGCTGTTTCCTCTCCTACCCCACCTTTAGATTTTACTCAGAGTTCAGTCTCCAGCCCTACAATCTGAGGGACACCTTTACCAGGTCC
CCTTCCTAACCCTCCAGTCCCAAATCCAAGATTCTTTAACCACACTCTAAAAGTTCTTCAGACTCAGGACTTAAACATAGCCACGCCACC
TTGGCCTTCAATGACAGGGATCTAGCAATGCTGCATCATCAGCCTTCCAATACCAGGTTTAAGGGTATTTTAAACACAGCTCCTCTTAAA
TCCTCCAATCTCAGTACCCAGTGTTTTAGCCATGCTCGGGTGGCTAAATTACATCCAGGAATGGTGCCAGGGCCTTTAGCCATTTGTCTC
TCCTCACACTCCAGGGCCCATATGGCCCAGGTTCTGACAGTTTGCCTTACTCCCTTGGGCTGGGGCTAGCCCTACCTGATACCCTGTGTC
AATGAGTGTACCTTGGAGAGCTATCCACTCAGGCCCCAGTGCCTCTATTTGCTAAGGGACTCTGCCACAGAAAAGAAGGGGAGAGATGTT
CATGTAACCTCAAAATACTTAGGCTTGGTTTTGATGCTAGAGAGGAAAAAGGACTTGGAGAGAGAGAAGGAATGGCTGGTCCAGAGGCTT
TTGTCCACTCCCTCTCACTGGAAGTGGTTGATCTCCAGGGAATCCCCAAGGTTAGCCTGCTTAGGGGAAGGGCTAGGGGTACCTGGAATG
TAGGATCTCCCCCATGCCTGGCCTACCACCCTAATGTGTCTGGAATTGGTGGGTTCTTGGTCTTGCTGACTTCAAGAATGAAGCCGTGGA

>45771_45771_5_LMCD1-ZNF589_LMCD1_chr3_8543666_ENST00000535732_ZNF589_chr3_48302303_ENST00000354698_length(amino acids)=375AA_BP=43
MAIQPPLSPLRALAPLPEKPGAVPPPQKRMAKVAKDLNPGVKKGPVTFEDVAVLFTEAEWKRLSLEQRNLYKEVMLENLRNLVSLAESKP
EVHTCPSCPLAFGSQQFLSQDELHNHPIPGFHAGNQLHPGNPCPEDQPQSQHPSDKNHRGAEAEDQRVEGGVRPLFWSTNERGALVGFSS
LFQRPPISSWGGNRILEIQLSPAQNASSEEVDRISKRAETPGFGAVTFGECALAFNQKSNLFRQKAVTAEKSSDKRQSQVCRECGRGFSR
KSQLIIHQRTHTGEKPYVCGECGRGFIVESVLRNHLSTHSGEKPYVCSHCGRGFSCKPYLIRHQRTHTREKSFMCTVCGRGFREKSELIK

--------------------------------------------------------------
>45771_45771_6_LMCD1-ZNF589_LMCD1_chr3_8543666_ENST00000535732_ZNF589_chr3_48302303_ENST00000412564_length(transcript)=582nt_BP=156nt
ACAGAGCTCCCTCCCAGGCCCGCGAACTTGGCCATTCAGCCGCCGCTGTCCCCGCTGCGCGCCCTCGCGCCTCTGCCTGAGAAGCCAGGC
GCTGTTCCCCCACCCCAGAAGAGGATGGCAAAGGTGGCTAAGGACCTCAACCCAGGAGTTAAAAAGGGACCAGTGACTTTCGAGGATGTG
GCTGTGCTTTTCACTGAGGCAGAGTGGAAGAGACTGAGCCTTGAGCAGAGGAACCTATACAAAGAAGTGATGCTGGAAAATCTCAGGAAT
CTGGTCTCATTGGTGCTCTCCTATCAAATCTAGAATTGGAAGATTGATGGACAGCAACTGAGGTGCTACCAGGATACCAAAAAGTCTGCT
GGATAAACACCATCTCTATTCTAATATTATGGAGAGATCAGGATCTCCTGTGCCCAAATCAAACCTGTTAATACACTCAGCTGTCCTCAG
TGGTAACACTGAGGTCAACACACAACTCCAACATCAGGAACAAGTCATAACCATTTTGCATCTGAAACAGTGCCTGACACAAAGGTGCTT

>45771_45771_6_LMCD1-ZNF589_LMCD1_chr3_8543666_ENST00000535732_ZNF589_chr3_48302303_ENST00000412564_length(amino acids)=91AA_BP=43
MAIQPPLSPLRALAPLPEKPGAVPPPQKRMAKVAKDLNPGVKKGPVTFEDVAVLFTEAEWKRLSLEQRNLYKEVMLENLRNLVSLVLSYQ

--------------------------------------------------------------
>45771_45771_7_LMCD1-ZNF589_LMCD1_chr3_8543666_ENST00000535732_ZNF589_chr3_48302303_ENST00000427617_length(transcript)=1665nt_BP=156nt
ACAGAGCTCCCTCCCAGGCCCGCGAACTTGGCCATTCAGCCGCCGCTGTCCCCGCTGCGCGCCCTCGCGCCTCTGCCTGAGAAGCCAGGC
GCTGTTCCCCCACCCCAGAAGAGGATGGCAAAGGTGGCTAAGGACCTCAACCCAGGAGTTAAAAAGGGACCAGTGACTTTCGAGGATGTG
GCTGTGCTTTTCACTGAGGCAGAGTGGAAGAGACTGAGCCTTGAGCAGAGGAACCTATACAAAGAAGTGATGCTGGAAAATCTCAGGAAT
CTGGTCTCATTGGTTCTGGAACTGGGAAGTCCAAGATCAGGGCTCCTGCCCCTGGACCTGAACCTGGATCTTTGGCTTTGATGTTGGACC
TTGTGTGTGGATATGAACTTTGAACCTGCACCTTGGAACTAAACCTCTGACTTGGATTTGTTCTGCATTTTGGAACTCACCTTAGACCTG
AACCTTGGTCATGAAATGGATCTGAATCATTCTTGGGTCTTGGACATGGGACTTGGACCTCCATGTGTATCTTGGACTTAGGACCATGAT
CTGGACCTTGTAAATTGACTTGGACTTTGGACTTGGACCTTGGACTAGAATTTGTCCCTGGCTGTGGACCTCGTCTTTGGATCTGGATCT
GGACCTGGTCTTGGATGTTGGACCTAGATGCAGGCCTTGATTTGATTTGGAACATGGACTTGGTCCTTGCACATGGCCCAACACCCGCGT
CTTTGGAACTGCATCTTGGACCTTGGATCTGAAATTTAAACAGGGAGGTGACCTTCATTTCTTGTATTTGACTTTATAACTGGAAATTCA
ATCTCTACCTGGATCTTGGACCTGGATCTCAGACCTTGCTTTTTATTGGGCCATGGATCTTATACCTTAAACATGGAAATTGTACCTGGA
TTTGGACCTTTGACTTGGACCTGGATCTGGACCCAGGGATAAGATTTGGACCTCACTTGCAAATTTTGGTAATGAAATTTTCCTTTGCTC
CTGTAGTCCTTGGACCTAGGCTTCAGTCATGGATTTAGACCTTAGACGTGACCATCAGACCTTAGAGTTGAACCTAAATTCCTGGTCCCC
AGTCCTATAACTCAGAATGATTATGCATAACCTTGGACTTAGAACTTAGATCTGGATCTTAGAGCTGATACTTGACCTGGTACTGGATAT
TTAACCTTGGACTTCAGACATGGATTTAATCTGGGCCTTGGGATGATTTAAGATCTAGAAGTGGACCTAGAATTAGACCTTGGACTTATG
TGCCTGAGCCTGGACTTTGGAAGTGGACTTTGGGCCTTGTAACTCAACCTTGAATATGAGCCTCAAATGTAGACTGTGGGCCAGGCACAG
TGGCTCACATCTGTAATCCCAGCACTTTGGGTGGAAAGCTGAGGCAGGTGGATCACTTGAGCTCAGGAATTCAAGACCAGCCTGGGGAAC
ATGGTGAAAACCTGGCTCTACAAAAAATAAAAAAATTAGCCAGGCTTGGTGGCACACACCTGTAGTTCCAGGTACTCAGGAGGCTGAGGC
AGGAGGTTCACTTGGGCCCAGGAGGCAGAGGTTGCAGTGAGCTGAGCTTGTACAGCTGCACTCCAGCCTGGAGGACAGAGTGAGACTCTG

>45771_45771_7_LMCD1-ZNF589_LMCD1_chr3_8543666_ENST00000535732_ZNF589_chr3_48302303_ENST00000427617_length(amino acids)=113AA_BP=
MKVTSLFKFQIQGPRCSSKDAGVGPCARTKSMFQIKSRPASRSNIQDQVQIQIQRRGPQPGTNSSPRSKSKVQVNLQGPDHGPKSKIHME

--------------------------------------------------------------
>45771_45771_8_LMCD1-ZNF589_LMCD1_chr3_8543666_ENST00000535732_ZNF589_chr3_48302303_ENST00000440261_length(transcript)=911nt_BP=156nt
ACAGAGCTCCCTCCCAGGCCCGCGAACTTGGCCATTCAGCCGCCGCTGTCCCCGCTGCGCGCCCTCGCGCCTCTGCCTGAGAAGCCAGGC
GCTGTTCCCCCACCCCAGAAGAGGATGGCAAAGGTGGCTAAGGACCTCAACCCAGGAGTTAAAAAGGGACCAGTGACTTTCGAGGATGTG
GCTGTGCTTTTCACTGAGGCAGAGTGGAAGAGACTGAGCCTTGAGCAGAGGAACCTATACAAAGAAGTGATGCTGGAAAATCTCAGGAAT
CTGGTCTCATTGGAATCAAAGCCAGAAGTCCATACCTGCCCTTCTTGCCCTCTGGCCTTTGGCAGTCAGCAGTTCCTCAGCCAAGATGAG
CTACACAATCATCCTATTCCAGGTTTCCATGCAGGAAATCAACTCCACCCAGGAAATCCCTGCCCAGAGGATCAGCCACAGTCACAACAT
CCTTCTGATAAAAATCACAGGGGGGCTGAAGCAGAAGATCAACGAGTGGAAGGAGGCGTCAGACCCTTGTTTTGGATTCTGGAACTGGGA
AGTCCAAGATCAGGGCTCCTGCCCCTGGACCTGAACCTGGATCTTTGGCTTTGATGTTGGACCTTGTGTGTGGATATGAACTTTGAACCT
GCACCTTGGAACTAAACCTCTGACTTGGATTTGTTCTGCATTTTGGAACTCACCTTAGACCTGAACCTTGGTCATGAAATGGATCTGAAT
CATTCTTGGGTCTTGGACATGGGACTTGGACCTCCATGTGTATCTTGGACTTAGGACCATGATCTGGACCTTGTAAATTGACTTGGACTT
TGGACTTGGACCTTGGACTAGAATTTGTCCCTGGCTGTGGACCTCGTCTTTGGATCTGGATCTGGACCTGGTCTTGGATGTTGGACCTAG

>45771_45771_8_LMCD1-ZNF589_LMCD1_chr3_8543666_ENST00000535732_ZNF589_chr3_48302303_ENST00000440261_length(amino acids)=188AA_BP=43
MAIQPPLSPLRALAPLPEKPGAVPPPQKRMAKVAKDLNPGVKKGPVTFEDVAVLFTEAEWKRLSLEQRNLYKEVMLENLRNLVSLESKPE
VHTCPSCPLAFGSQQFLSQDELHNHPIPGFHAGNQLHPGNPCPEDQPQSQHPSDKNHRGAEAEDQRVEGGVRPLFWILELGSPRSGLLPL

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for LMCD1-ZNF589

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for LMCD1-ZNF589

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for LMCD1-ZNF589

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source