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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:LMF1-CCDC154 (FusionGDB2 ID:45772)

Fusion Gene Summary for LMF1-CCDC154

Fusion gene summary

Fusion gene information	Fusion gene name: LMF1-CCDC154
	Fusion gene ID: 45772
		Hgene	Tgene
	Gene symbol	LMF1	CCDC154
	Gene ID	64788	645811
	Gene name	lipase maturation factor 1	coiled-coil domain containing 154
	Synonyms	C16orf26\|HMFN1876\|JFP11\|TMEM112\|TMEM112A	C16orf29
	Cytomap	16p13.3	16p13.3
	Type of gene	protein-coding	protein-coding
	Description	lipase maturation factor 1transmembrane protein 112	coiled-coil domain-containing protein 154
	Modification date	20200313	20200313
	UniProtAcc	Q96S06	.
	Ensembl transtripts involved in fusion gene	ENST00000539379, ENST00000262301, ENST00000399843, ENST00000568897, ENST00000543238, ENST00000568268,	ENST00000389176, ENST00000409671,
Fusion gene scores	* DoF score	1 X 1 X 1=1	1 X 1 X 1=1
	# samples	1	1
	** MAII score	log2(1/1*10)=3.32192809488736	log2(1/1*10)=3.32192809488736
Context	PubMed: LMF1 [Title/Abstract] AND CCDC154 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	LMF1(960931)-CCDC154(1489127), # samples:2
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across LMF1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across CCDC154 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LGG	TCGA-DU-A6S2-01A	LMF1	chr16	960931	-	CCDC154	chr16	1489127	-

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Fusion Gene ORF analysis for LMF1-CCDC154

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
3UTR-3CDS	ENST00000539379	ENST00000389176	LMF1	chr16	960931	-	CCDC154	chr16	1489127	-
3UTR-3CDS	ENST00000539379	ENST00000409671	LMF1	chr16	960931	-	CCDC154	chr16	1489127	-
In-frame	ENST00000262301	ENST00000389176	LMF1	chr16	960931	-	CCDC154	chr16	1489127	-
In-frame	ENST00000262301	ENST00000409671	LMF1	chr16	960931	-	CCDC154	chr16	1489127	-
In-frame	ENST00000399843	ENST00000389176	LMF1	chr16	960931	-	CCDC154	chr16	1489127	-
In-frame	ENST00000399843	ENST00000409671	LMF1	chr16	960931	-	CCDC154	chr16	1489127	-
In-frame	ENST00000568897	ENST00000389176	LMF1	chr16	960931	-	CCDC154	chr16	1489127	-
In-frame	ENST00000568897	ENST00000409671	LMF1	chr16	960931	-	CCDC154	chr16	1489127	-
intron-3CDS	ENST00000543238	ENST00000389176	LMF1	chr16	960931	-	CCDC154	chr16	1489127	-
intron-3CDS	ENST00000543238	ENST00000409671	LMF1	chr16	960931	-	CCDC154	chr16	1489127	-
intron-3CDS	ENST00000568268	ENST00000389176	LMF1	chr16	960931	-	CCDC154	chr16	1489127	-
intron-3CDS	ENST00000568268	ENST00000409671	LMF1	chr16	960931	-	CCDC154	chr16	1489127	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000262301	LMF1	chr16	960931	-	ENST00000409671	CCDC154	chr16	1489127	-	2034	682	19	2010	663
ENST00000262301	LMF1	chr16	960931	-	ENST00000389176	CCDC154	chr16	1489127	-	2052	682	19	2031	670
ENST00000399843	LMF1	chr16	960931	-	ENST00000409671	CCDC154	chr16	1489127	-	2017	665	2	1993	663
ENST00000399843	LMF1	chr16	960931	-	ENST00000389176	CCDC154	chr16	1489127	-	2035	665	2	2014	670
ENST00000568897	LMF1	chr16	960931	-	ENST00000409671	CCDC154	chr16	1489127	-	1894	542	386	1870	494
ENST00000568897	LMF1	chr16	960931	-	ENST00000389176	CCDC154	chr16	1489127	-	1912	542	386	1891	501

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000262301	ENST00000409671	LMF1	chr16	960931	-	CCDC154	chr16	1489127	-	0.043009564	0.9569905
ENST00000262301	ENST00000389176	LMF1	chr16	960931	-	CCDC154	chr16	1489127	-	0.04437499	0.955625
ENST00000399843	ENST00000409671	LMF1	chr16	960931	-	CCDC154	chr16	1489127	-	0.0427162	0.9572838
ENST00000399843	ENST00000389176	LMF1	chr16	960931	-	CCDC154	chr16	1489127	-	0.04399601	0.95600396
ENST00000568897	ENST00000409671	LMF1	chr16	960931	-	CCDC154	chr16	1489127	-	0.016946755	0.98305327
ENST00000568897	ENST00000389176	LMF1	chr16	960931	-	CCDC154	chr16	1489127	-	0.017507967	0.98249197

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Fusion Genomic Features for LMF1-CCDC154

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for LMF1-CCDC154

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:960931/chr16:1489127)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
LMF1 Q96S06	.
FUNCTION: Involved in the maturation of specific proteins in the endoplasmic reticulum. Required for maturation and transport of active lipoprotein lipase (LPL) through the secretory pathway. Each LMF1 molecule chaperones 50 or more molecules of LPL. {ECO:0000250\|UniProtKB:Q3U3R4, ECO:0000269\|PubMed:24909692}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

LMF1

chr16:960931

chr16:1489127

ENST00000262301

152_207

221

568.0

Topological domain

Cytoplasmic

Hgene

LMF1

chr16:960931

chr16:1489127

ENST00000262301

1_49

221

568.0

Topological domain

Cytoplasmic

Hgene

LMF1

chr16:960931

chr16:1489127

ENST00000262301

73_127

221

568.0

Topological domain

Lumenal

Hgene

LMF1

chr16:960931

chr16:1489127

ENST00000262301

128_151

221

568.0

Transmembrane

Helical

Hgene

LMF1

chr16:960931

chr16:1489127

ENST00000262301

208_221

221

568.0

Transmembrane

Helical

Hgene

LMF1

chr16:960931

chr16:1489127

ENST00000262301

50_72

221

568.0

Transmembrane

Helical

Tgene

CCDC154

chr16:960931

chr16:1489127

ENST00000389176

384_410

225

675.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

CCDC154

chr16:960931

chr16:1489127

ENST00000389176

457_521

225

675.0

Coiled coil

Ontology_term=ECO:0000255

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

LMF1

chr16:960931

chr16:1489127

ENST00000262301

222_292

221

568.0

Topological domain

Lumenal

Hgene

LMF1

chr16:960931

chr16:1489127

ENST00000262301

322_367

221

568.0

Topological domain

Cytoplasmic

Hgene

LMF1

chr16:960931

chr16:1489127

ENST00000262301

389_567

221

568.0

Topological domain

Lumenal

Hgene

LMF1

chr16:960931

chr16:1489127

ENST00000262301

293_321

221

568.0

Transmembrane

Helical

Hgene

LMF1

chr16:960931

chr16:1489127

ENST00000262301

368_388

221

568.0

Transmembrane

Helical

Tgene

CCDC154

chr16:960931

chr16:1489127

ENST00000389176

215_302

225

675.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

CCDC154

chr16:960931

chr16:1489127

ENST00000389176

76_182

225

675.0

Coiled coil

Ontology_term=ECO:0000255

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Fusion Gene Sequence for LMF1-CCDC154

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>45772_45772_1_LMF1-CCDC154_LMF1_chr16_960931_ENST00000262301_CCDC154_chr16_1489127_ENST00000389176_length(transcript)=2052nt_BP=682nt
GAGTGCGCCCTCCCCGCACATGCGCCCTGACAGCCCAACAATGGCGGCGCCCGCGGAGTCGCTGAGGAGGCGGAAGACTGGGTACTCGGA
TCCGGAGCCTGAGTCGCCGCCCGCGCCGGGGCGTGGCCCCGCAGGCTCTCCGGCCCATCTCCACACGGGCACCTTCTGGCTGACCCGGAT
CGTGCTCCTGAAGGCCCTAGCCTTCGTGTACTTCGTGGCATTCCTGGTGGCTTTCCATCAGAACAAGCAGCTCATCGGTGACAGGGGGCT
GCTTCCCTGCAGAGTGTTCCTGAAGAACTTCCAGCAGTACTTCCAGGACAGGACGAGCTGGGAAGTCTTCAGCTACATGCCCACCATCCT
CTGGCTGATGGACTGGTCAGACATGAACTCCAACCTGGACTTGCTGGCTCTTCTCGGACTGGGCATCTCGTCTTTCGTACTGATCACGGG
CTGCGCCAACATGCTTCTCATGGCTGCCCTGTGGGGCCTCTACATGTCCCTGGTTAATGTGGGCCATGTCTGGTACTCTTTCGGATGGGA
GTCCCAGCTTCTGGAGACGGGGTTCCTGGGGATCTTCCTGTGCCCTCTGTGGACGCTGTCAAGGCTGCCCCAGCATACCCCCACATCCCG
GATTGTCCTGTGGGGCTTCCGGTGGCTGATCTTCAGGATCATGCTTGGAGCAGCCCAGGTGACCAAGCTCGGCGAAGAGGTGAGCCTGCG
CTTCCTGAAGAGGGAGGCCAAGCTGTGCGGCTTCCTGCAGAAGAGCTTCCTGGCCCTGGAGAAGAGAATGAAGGCCTCGGAGAGCTCACG
GCTGAAGCTGGAGGGCAGCCTGCGGGGCGAGCTGGAGAGCCGGTGGGAGAAGCTTCGGGGGCTGATGGAGGAGCGCCTGCGGGCCCTGCA
GGGGCAGCATGAGGTGGGGCCGGGCGGGCGGCGGGCAGAGGAGAGCCACCTCCTGGAGCAGTGCCAGGGCCTGGATGCTGCCGTGGCCCA
GCTGACCAAGTTTGTGCAGCAGAACCAGGCGTCGCTGAACCGTGTCCTACTGGCCGAGGAGAAAGCCTGGGACGCCAAGGGGCGCTTGGA
GGAAAGCCGGGCTGGGGAGCTGGCCGCCTATGTGCAGGAGAACCTGGAGGCCGCACAGCTGGCTGGCGAGCTGGCCCGGCAGGAGATGCA
TGGAGAGCTGGTGCTGCTCCGAGAGAAGAGCCGGGCTCTGGAGGCATCCGTGGCGCAGCTGGCCGGGCAGTTAAAGGAGCTGAGTGGCCA
TCTCCCGGCTCTGAGCAGCCGGCTCGATCTGCAGGAGCAGATGCTGGGCCTCAGGCTGTCCGAGGCAAAGACCGAATGGGAAGGTGCAGA
GAGGAAGTCCCTGGAGGACCTGGCCAGGTGGCGGAAGGAGGTGACCGAACACCTGCGAGGGGTGCGGGAGAAGGTGGATGGCCTCCCCCA
GCAGATAGAGAGTGTCTCCGACAAGTGCCTGCTTCATAAGAGCGACTCAGACCTCAGGATTTCCGCCGAAGGCAAGGCCAGGGAGTTCAA
GGTTGGGGCCCTGCGGCAGGAGCTGGCCACGCTACTATCATCCGTGCAGCTGCTAAAGGAAGACAACCCTGGGCGGAAGATCGCGGAGAT
GCAGGGCAAGCTGGCCACGAACCAAATAATGAAGCTGGAAAACTGCGTCCAGGCCAACAAGACCATCCAGAACCTCAGGTTCAACACTGA
GGCCCGGCTGCGCACGCAGGAGATGGCCACCCTGTGGGAGAGTGTGCTCCGGCTGTGGAGTGAGGAGGGCCCGCGGACGCCGCTGGGCAG
CTGGAAGGCGCTCCCATCCCTGGTGAGGCCGCGGGTCTTCATCAAGGACATGGCGCCTGGCAAGGTGGTGCCCATGAACTGCTGGGGCGT
GTACCAGGCTGTGAGGTGGCTGCGCTGGAAGGCGTCCCTCATAAAGCTCAGGGCCCTGCGGAGGCCAGGAGGGGTCCTGGAGAAGCCCCA

>45772_45772_1_LMF1-CCDC154_LMF1_chr16_960931_ENST00000262301_CCDC154_chr16_1489127_ENST00000389176_length(amino acids)=670AA_BP=221
MRPDSPTMAAPAESLRRRKTGYSDPEPESPPAPGRGPAGSPAHLHTGTFWLTRIVLLKALAFVYFVAFLVAFHQNKQLIGDRGLLPCRVF
LKNFQQYFQDRTSWEVFSYMPTILWLMDWSDMNSNLDLLALLGLGISSFVLITGCANMLLMAALWGLYMSLVNVGHVWYSFGWESQLLET
GFLGIFLCPLWTLSRLPQHTPTSRIVLWGFRWLIFRIMLGAAQVTKLGEEVSLRFLKREAKLCGFLQKSFLALEKRMKASESSRLKLEGS
LRGELESRWEKLRGLMEERLRALQGQHEVGPGGRRAEESHLLEQCQGLDAAVAQLTKFVQQNQASLNRVLLAEEKAWDAKGRLEESRAGE
LAAYVQENLEAAQLAGELARQEMHGELVLLREKSRALEASVAQLAGQLKELSGHLPALSSRLDLQEQMLGLRLSEAKTEWEGAERKSLED
LARWRKEVTEHLRGVREKVDGLPQQIESVSDKCLLHKSDSDLRISAEGKAREFKVGALRQELATLLSSVQLLKEDNPGRKIAEMQGKLAT
NQIMKLENCVQANKTIQNLRFNTEARLRTQEMATLWESVLRLWSEEGPRTPLGSWKALPSLVRPRVFIKDMAPGKVVPMNCWGVYQAVRW

--------------------------------------------------------------
>45772_45772_2_LMF1-CCDC154_LMF1_chr16_960931_ENST00000262301_CCDC154_chr16_1489127_ENST00000409671_length(transcript)=2034nt_BP=682nt
GAGTGCGCCCTCCCCGCACATGCGCCCTGACAGCCCAACAATGGCGGCGCCCGCGGAGTCGCTGAGGAGGCGGAAGACTGGGTACTCGGA
TCCGGAGCCTGAGTCGCCGCCCGCGCCGGGGCGTGGCCCCGCAGGCTCTCCGGCCCATCTCCACACGGGCACCTTCTGGCTGACCCGGAT
CGTGCTCCTGAAGGCCCTAGCCTTCGTGTACTTCGTGGCATTCCTGGTGGCTTTCCATCAGAACAAGCAGCTCATCGGTGACAGGGGGCT
GCTTCCCTGCAGAGTGTTCCTGAAGAACTTCCAGCAGTACTTCCAGGACAGGACGAGCTGGGAAGTCTTCAGCTACATGCCCACCATCCT
CTGGCTGATGGACTGGTCAGACATGAACTCCAACCTGGACTTGCTGGCTCTTCTCGGACTGGGCATCTCGTCTTTCGTACTGATCACGGG
CTGCGCCAACATGCTTCTCATGGCTGCCCTGTGGGGCCTCTACATGTCCCTGGTTAATGTGGGCCATGTCTGGTACTCTTTCGGATGGGA
GTCCCAGCTTCTGGAGACGGGGTTCCTGGGGATCTTCCTGTGCCCTCTGTGGACGCTGTCAAGGCTGCCCCAGCATACCCCCACATCCCG
GATTGTCCTGTGGGGCTTCCGGTGGCTGATCTTCAGGATCATGCTTGGAGCAGCCCAGGTGACCAAGCTCGGCGAAGAGGTGAGCCTGCG
CTTCCTGAAGAGGGAGGCCAAGCTGTGCGGCTTCCTGCAGAAGAGCTTCCTGGCCCTGGAGAAGAGAATGAAGGCCTCGGAGAGCTCACG
GCTGAAGCTGGAGGGCAGCCTGCGGGGCGAGCTGGAGAGCCGGTGGGAGAAGCTTCGGGGGCTGATGGAGGAGCGCCTGCGGGCCCTGCA
GGGGCAGCATGAGGAGAGCCACCTCCTGGAGCAGTGCCAGGGCCTGGATGCTGCCGTGGCCCAGCTGACCAAGTTTGTGCAGCAGAACCA
GGCGTCGCTGAACCGTGTCCTACTGGCCGAGGAGAAAGCCTGGGACGCCAAGGGGCGCTTGGAGGAAAGCCGGGCTGGGGAGCTGGCCGC
CTATGTGCAGGAGAACCTGGAGGCCGCACAGCTGGCTGGCGAGCTGGCCCGGCAGGAGATGCATGGAGAGCTGGTGCTGCTCCGAGAGAA
GAGCCGGGCTCTGGAGGCATCCGTGGCGCAGCTGGCCGGGCAGTTAAAGGAGCTGAGTGGCCATCTCCCGGCTCTGAGCAGCCGGCTCGA
TCTGCAGGAGCAGATGCTGGGCCTCAGGCTGTCCGAGGCAAAGACCGAATGGGAAGGTGCAGAGAGGAAGTCCCTGGAGGACCTGGCCAG
GTGGCGGAAGGAGGTGACCGAACACCTGCGAGGGGTGCGGGAGAAGGTGGATGGCCTCCCCCAGCAGATAGAGAGTGTCTCCGACAAGTG
CCTGCTTCATAAGAGCGACTCAGACCTCAGGATTTCCGCCGAAGGCAAGGCCAGGGAGTTCAAGGTTGGGGCCCTGCGGCAGGAGCTGGC
CACGCTACTATCATCCGTGCAGCTGCTAAAGGAAGACAACCCTGGGCGGAAGATCGCGGAGATGCAGGGCAAGCTGGCCACGTTTCAGAA
CCAAATAATGAAGCTGGAAAACTGCGTCCAGGCCAACAAGACCATCCAGAACCTCAGGTTCAACACTGAGGCCCGGCTGCGCACGCAGGA
GATGGCCACCCTGTGGGAGAGTGTGCTCCGGCTGTGGAGTGAGGAGGGCCCGCGGACGCCGCTGGGCAGCTGGAAGGCGCTCCCATCCCT
GGTGAGGCCGCGGGTCTTCATCAAGGACATGGCGCCTGGCAAGGTGGTGCCCATGAACTGCTGGGGCGTGTACCAGGCTGTGAGGTGGCT
GCGCTGGAAGGCGTCCCTCATAAAGCTCAGGGCCCTGCGGAGGCCAGGAGGGGTCCTGGAGAAGCCCCACAGCCAGGAGCAGGTGCAGCA

>45772_45772_2_LMF1-CCDC154_LMF1_chr16_960931_ENST00000262301_CCDC154_chr16_1489127_ENST00000409671_length(amino acids)=663AA_BP=221
MRPDSPTMAAPAESLRRRKTGYSDPEPESPPAPGRGPAGSPAHLHTGTFWLTRIVLLKALAFVYFVAFLVAFHQNKQLIGDRGLLPCRVF
LKNFQQYFQDRTSWEVFSYMPTILWLMDWSDMNSNLDLLALLGLGISSFVLITGCANMLLMAALWGLYMSLVNVGHVWYSFGWESQLLET
GFLGIFLCPLWTLSRLPQHTPTSRIVLWGFRWLIFRIMLGAAQVTKLGEEVSLRFLKREAKLCGFLQKSFLALEKRMKASESSRLKLEGS
LRGELESRWEKLRGLMEERLRALQGQHEESHLLEQCQGLDAAVAQLTKFVQQNQASLNRVLLAEEKAWDAKGRLEESRAGELAAYVQENL
EAAQLAGELARQEMHGELVLLREKSRALEASVAQLAGQLKELSGHLPALSSRLDLQEQMLGLRLSEAKTEWEGAERKSLEDLARWRKEVT
EHLRGVREKVDGLPQQIESVSDKCLLHKSDSDLRISAEGKAREFKVGALRQELATLLSSVQLLKEDNPGRKIAEMQGKLATFQNQIMKLE
NCVQANKTIQNLRFNTEARLRTQEMATLWESVLRLWSEEGPRTPLGSWKALPSLVRPRVFIKDMAPGKVVPMNCWGVYQAVRWLRWKASL

--------------------------------------------------------------
>45772_45772_3_LMF1-CCDC154_LMF1_chr16_960931_ENST00000399843_CCDC154_chr16_1489127_ENST00000389176_length(transcript)=2035nt_BP=665nt
ACATGCGCCCTGACAGCCCAACAATGGCGGCGCCCGCGGAGTCGCTGAGGAGGCGGAAGACTGGGTACTCGGATCCGGAGCCTGAGTCGC
CGCCCGCGCCGGGGCGTGGCCCCGCAGGCTCTCCGGCCCATCTCCACACGGGCACCTTCTGGCTGACCCGGATCGTGCTCCTGAAGGCCC
TAGCCTTCGTGTACTTCGTGGCATTCCTGGTGGCTTTCCATCAGAACAAGCAGCTCATCGGTGACAGGGGGCTGCTTCCCTGCAGAGTGT
TCCTGAAGAACTTCCAGCAGTACTTCCAGGACAGGACGAGCTGGGAAGTCTTCAGCTACATGCCCACCATCCTCTGGCTGATGGACTGGT
CAGACATGAACTCCAACCTGGACTTGCTGGCTCTTCTCGGACTGGGCATCTCGTCTTTCGTACTGATCACGGGCTGCGCCAACATGCTTC
TCATGGCTGCCCTGTGGGGCCTCTACATGTCCCTGGTTAATGTGGGCCATGTCTGGTATTCCTTCAGATGGGAGTCCCAGCTTCTGGAGA
CGGGGTTCCTGGGGATCTTCCTGTGCCCTCTGTGGACGCTGTCAAGGCTGCCCCAGCATACCCCCACATCCCGGATTGTCCTGTGGGGCT
TCCGGTGGCTGATCTTCAGGATCATGCTTGGAGCAGCCCAGGTGACCAAGCTCGGCGAAGAGGTGAGCCTGCGCTTCCTGAAGAGGGAGG
CCAAGCTGTGCGGCTTCCTGCAGAAGAGCTTCCTGGCCCTGGAGAAGAGAATGAAGGCCTCGGAGAGCTCACGGCTGAAGCTGGAGGGCA
GCCTGCGGGGCGAGCTGGAGAGCCGGTGGGAGAAGCTTCGGGGGCTGATGGAGGAGCGCCTGCGGGCCCTGCAGGGGCAGCATGAGGTGG
GGCCGGGCGGGCGGCGGGCAGAGGAGAGCCACCTCCTGGAGCAGTGCCAGGGCCTGGATGCTGCCGTGGCCCAGCTGACCAAGTTTGTGC
AGCAGAACCAGGCGTCGCTGAACCGTGTCCTACTGGCCGAGGAGAAAGCCTGGGACGCCAAGGGGCGCTTGGAGGAAAGCCGGGCTGGGG
AGCTGGCCGCCTATGTGCAGGAGAACCTGGAGGCCGCACAGCTGGCTGGCGAGCTGGCCCGGCAGGAGATGCATGGAGAGCTGGTGCTGC
TCCGAGAGAAGAGCCGGGCTCTGGAGGCATCCGTGGCGCAGCTGGCCGGGCAGTTAAAGGAGCTGAGTGGCCATCTCCCGGCTCTGAGCA
GCCGGCTCGATCTGCAGGAGCAGATGCTGGGCCTCAGGCTGTCCGAGGCAAAGACCGAATGGGAAGGTGCAGAGAGGAAGTCCCTGGAGG
ACCTGGCCAGGTGGCGGAAGGAGGTGACCGAACACCTGCGAGGGGTGCGGGAGAAGGTGGATGGCCTCCCCCAGCAGATAGAGAGTGTCT
CCGACAAGTGCCTGCTTCATAAGAGCGACTCAGACCTCAGGATTTCCGCCGAAGGCAAGGCCAGGGAGTTCAAGGTTGGGGCCCTGCGGC
AGGAGCTGGCCACGCTACTATCATCCGTGCAGCTGCTAAAGGAAGACAACCCTGGGCGGAAGATCGCGGAGATGCAGGGCAAGCTGGCCA
CGAACCAAATAATGAAGCTGGAAAACTGCGTCCAGGCCAACAAGACCATCCAGAACCTCAGGTTCAACACTGAGGCCCGGCTGCGCACGC
AGGAGATGGCCACCCTGTGGGAGAGTGTGCTCCGGCTGTGGAGTGAGGAGGGCCCGCGGACGCCGCTGGGCAGCTGGAAGGCGCTCCCAT
CCCTGGTGAGGCCGCGGGTCTTCATCAAGGACATGGCGCCTGGCAAGGTGGTGCCCATGAACTGCTGGGGCGTGTACCAGGCTGTGAGGT
GGCTGCGCTGGAAGGCGTCCCTCATAAAGCTCAGGGCCCTGCGGAGGCCAGGAGGGGTCCTGGAGAAGCCCCACAGCCAGGAGCAGGTGC

>45772_45772_3_LMF1-CCDC154_LMF1_chr16_960931_ENST00000399843_CCDC154_chr16_1489127_ENST00000389176_length(amino acids)=670AA_BP=221
MRPDSPTMAAPAESLRRRKTGYSDPEPESPPAPGRGPAGSPAHLHTGTFWLTRIVLLKALAFVYFVAFLVAFHQNKQLIGDRGLLPCRVF
LKNFQQYFQDRTSWEVFSYMPTILWLMDWSDMNSNLDLLALLGLGISSFVLITGCANMLLMAALWGLYMSLVNVGHVWYSFRWESQLLET
GFLGIFLCPLWTLSRLPQHTPTSRIVLWGFRWLIFRIMLGAAQVTKLGEEVSLRFLKREAKLCGFLQKSFLALEKRMKASESSRLKLEGS
LRGELESRWEKLRGLMEERLRALQGQHEVGPGGRRAEESHLLEQCQGLDAAVAQLTKFVQQNQASLNRVLLAEEKAWDAKGRLEESRAGE
LAAYVQENLEAAQLAGELARQEMHGELVLLREKSRALEASVAQLAGQLKELSGHLPALSSRLDLQEQMLGLRLSEAKTEWEGAERKSLED
LARWRKEVTEHLRGVREKVDGLPQQIESVSDKCLLHKSDSDLRISAEGKAREFKVGALRQELATLLSSVQLLKEDNPGRKIAEMQGKLAT
NQIMKLENCVQANKTIQNLRFNTEARLRTQEMATLWESVLRLWSEEGPRTPLGSWKALPSLVRPRVFIKDMAPGKVVPMNCWGVYQAVRW

--------------------------------------------------------------
>45772_45772_4_LMF1-CCDC154_LMF1_chr16_960931_ENST00000399843_CCDC154_chr16_1489127_ENST00000409671_length(transcript)=2017nt_BP=665nt
ACATGCGCCCTGACAGCCCAACAATGGCGGCGCCCGCGGAGTCGCTGAGGAGGCGGAAGACTGGGTACTCGGATCCGGAGCCTGAGTCGC
CGCCCGCGCCGGGGCGTGGCCCCGCAGGCTCTCCGGCCCATCTCCACACGGGCACCTTCTGGCTGACCCGGATCGTGCTCCTGAAGGCCC
TAGCCTTCGTGTACTTCGTGGCATTCCTGGTGGCTTTCCATCAGAACAAGCAGCTCATCGGTGACAGGGGGCTGCTTCCCTGCAGAGTGT
TCCTGAAGAACTTCCAGCAGTACTTCCAGGACAGGACGAGCTGGGAAGTCTTCAGCTACATGCCCACCATCCTCTGGCTGATGGACTGGT
CAGACATGAACTCCAACCTGGACTTGCTGGCTCTTCTCGGACTGGGCATCTCGTCTTTCGTACTGATCACGGGCTGCGCCAACATGCTTC
TCATGGCTGCCCTGTGGGGCCTCTACATGTCCCTGGTTAATGTGGGCCATGTCTGGTATTCCTTCAGATGGGAGTCCCAGCTTCTGGAGA
CGGGGTTCCTGGGGATCTTCCTGTGCCCTCTGTGGACGCTGTCAAGGCTGCCCCAGCATACCCCCACATCCCGGATTGTCCTGTGGGGCT
TCCGGTGGCTGATCTTCAGGATCATGCTTGGAGCAGCCCAGGTGACCAAGCTCGGCGAAGAGGTGAGCCTGCGCTTCCTGAAGAGGGAGG
CCAAGCTGTGCGGCTTCCTGCAGAAGAGCTTCCTGGCCCTGGAGAAGAGAATGAAGGCCTCGGAGAGCTCACGGCTGAAGCTGGAGGGCA
GCCTGCGGGGCGAGCTGGAGAGCCGGTGGGAGAAGCTTCGGGGGCTGATGGAGGAGCGCCTGCGGGCCCTGCAGGGGCAGCATGAGGAGA
GCCACCTCCTGGAGCAGTGCCAGGGCCTGGATGCTGCCGTGGCCCAGCTGACCAAGTTTGTGCAGCAGAACCAGGCGTCGCTGAACCGTG
TCCTACTGGCCGAGGAGAAAGCCTGGGACGCCAAGGGGCGCTTGGAGGAAAGCCGGGCTGGGGAGCTGGCCGCCTATGTGCAGGAGAACC
TGGAGGCCGCACAGCTGGCTGGCGAGCTGGCCCGGCAGGAGATGCATGGAGAGCTGGTGCTGCTCCGAGAGAAGAGCCGGGCTCTGGAGG
CATCCGTGGCGCAGCTGGCCGGGCAGTTAAAGGAGCTGAGTGGCCATCTCCCGGCTCTGAGCAGCCGGCTCGATCTGCAGGAGCAGATGC
TGGGCCTCAGGCTGTCCGAGGCAAAGACCGAATGGGAAGGTGCAGAGAGGAAGTCCCTGGAGGACCTGGCCAGGTGGCGGAAGGAGGTGA
CCGAACACCTGCGAGGGGTGCGGGAGAAGGTGGATGGCCTCCCCCAGCAGATAGAGAGTGTCTCCGACAAGTGCCTGCTTCATAAGAGCG
ACTCAGACCTCAGGATTTCCGCCGAAGGCAAGGCCAGGGAGTTCAAGGTTGGGGCCCTGCGGCAGGAGCTGGCCACGCTACTATCATCCG
TGCAGCTGCTAAAGGAAGACAACCCTGGGCGGAAGATCGCGGAGATGCAGGGCAAGCTGGCCACGTTTCAGAACCAAATAATGAAGCTGG
AAAACTGCGTCCAGGCCAACAAGACCATCCAGAACCTCAGGTTCAACACTGAGGCCCGGCTGCGCACGCAGGAGATGGCCACCCTGTGGG
AGAGTGTGCTCCGGCTGTGGAGTGAGGAGGGCCCGCGGACGCCGCTGGGCAGCTGGAAGGCGCTCCCATCCCTGGTGAGGCCGCGGGTCT
TCATCAAGGACATGGCGCCTGGCAAGGTGGTGCCCATGAACTGCTGGGGCGTGTACCAGGCTGTGAGGTGGCTGCGCTGGAAGGCGTCCC
TCATAAAGCTCAGGGCCCTGCGGAGGCCAGGAGGGGTCCTGGAGAAGCCCCACAGCCAGGAGCAGGTGCAGCAGCTCACACCCTCACTGT

>45772_45772_4_LMF1-CCDC154_LMF1_chr16_960931_ENST00000399843_CCDC154_chr16_1489127_ENST00000409671_length(amino acids)=663AA_BP=221
MRPDSPTMAAPAESLRRRKTGYSDPEPESPPAPGRGPAGSPAHLHTGTFWLTRIVLLKALAFVYFVAFLVAFHQNKQLIGDRGLLPCRVF
LKNFQQYFQDRTSWEVFSYMPTILWLMDWSDMNSNLDLLALLGLGISSFVLITGCANMLLMAALWGLYMSLVNVGHVWYSFRWESQLLET
GFLGIFLCPLWTLSRLPQHTPTSRIVLWGFRWLIFRIMLGAAQVTKLGEEVSLRFLKREAKLCGFLQKSFLALEKRMKASESSRLKLEGS
LRGELESRWEKLRGLMEERLRALQGQHEESHLLEQCQGLDAAVAQLTKFVQQNQASLNRVLLAEEKAWDAKGRLEESRAGELAAYVQENL
EAAQLAGELARQEMHGELVLLREKSRALEASVAQLAGQLKELSGHLPALSSRLDLQEQMLGLRLSEAKTEWEGAERKSLEDLARWRKEVT
EHLRGVREKVDGLPQQIESVSDKCLLHKSDSDLRISAEGKAREFKVGALRQELATLLSSVQLLKEDNPGRKIAEMQGKLATFQNQIMKLE
NCVQANKTIQNLRFNTEARLRTQEMATLWESVLRLWSEEGPRTPLGSWKALPSLVRPRVFIKDMAPGKVVPMNCWGVYQAVRWLRWKASL

--------------------------------------------------------------
>45772_45772_5_LMF1-CCDC154_LMF1_chr16_960931_ENST00000568897_CCDC154_chr16_1489127_ENST00000389176_length(transcript)=1912nt_BP=542nt
GGCTCTCCGGCCCATCTCCACACGGGCACCTTCTGGCTGACCCGGATCGTGCTCCTGAAGGCCCTAGCCTTCGTGTACTTCGTGGCATTC
CTGGTGGCTTTCCATCAGAACAAGCAGCTCATCGGTGACAGGGGGCTGCTTCCCTGCAGAGTGTTCCTGAAGAACTTCCAGCAGTACTTC
CAGGACAGGACGAGCTGGGAAGTCTTCAGCTACATGCCCACCATCCTCTGGCTGATGGACTGGTCAGACATGAACTCCAACCTGGACTTG
CTGGCTCTTCTCGGACTGGGCATCTCGTCTTTCGTACTGATCACGGGCTGCGCCAACATGCTTCTCATGGCTGCCCTGTGGGGCCTCTAC
ATGTCCCTGGTTAATGTGGGCCATGTCTGGTGAGATGGGAGTCCCAGCTTCTGGAGACGGGGTTCCTGGGGATCTTCCTGTGCCCTCTGT
GGACGCTGTCAAGGCTGCCCCAGCATACCCCCACATCCCGGATTGTCCTGTGGGGCTTCCGGTGGCTGATCTTCAGGATCATGCTTGGAG
CAGCCCAGGTGACCAAGCTCGGCGAAGAGGTGAGCCTGCGCTTCCTGAAGAGGGAGGCCAAGCTGTGCGGCTTCCTGCAGAAGAGCTTCC
TGGCCCTGGAGAAGAGAATGAAGGCCTCGGAGAGCTCACGGCTGAAGCTGGAGGGCAGCCTGCGGGGCGAGCTGGAGAGCCGGTGGGAGA
AGCTTCGGGGGCTGATGGAGGAGCGCCTGCGGGCCCTGCAGGGGCAGCATGAGGTGGGGCCGGGCGGGCGGCGGGCAGAGGAGAGCCACC
TCCTGGAGCAGTGCCAGGGCCTGGATGCTGCCGTGGCCCAGCTGACCAAGTTTGTGCAGCAGAACCAGGCGTCGCTGAACCGTGTCCTAC
TGGCCGAGGAGAAAGCCTGGGACGCCAAGGGGCGCTTGGAGGAAAGCCGGGCTGGGGAGCTGGCCGCCTATGTGCAGGAGAACCTGGAGG
CCGCACAGCTGGCTGGCGAGCTGGCCCGGCAGGAGATGCATGGAGAGCTGGTGCTGCTCCGAGAGAAGAGCCGGGCTCTGGAGGCATCCG
TGGCGCAGCTGGCCGGGCAGTTAAAGGAGCTGAGTGGCCATCTCCCGGCTCTGAGCAGCCGGCTCGATCTGCAGGAGCAGATGCTGGGCC
TCAGGCTGTCCGAGGCAAAGACCGAATGGGAAGGTGCAGAGAGGAAGTCCCTGGAGGACCTGGCCAGGTGGCGGAAGGAGGTGACCGAAC
ACCTGCGAGGGGTGCGGGAGAAGGTGGATGGCCTCCCCCAGCAGATAGAGAGTGTCTCCGACAAGTGCCTGCTTCATAAGAGCGACTCAG
ACCTCAGGATTTCCGCCGAAGGCAAGGCCAGGGAGTTCAAGGTTGGGGCCCTGCGGCAGGAGCTGGCCACGCTACTATCATCCGTGCAGC
TGCTAAAGGAAGACAACCCTGGGCGGAAGATCGCGGAGATGCAGGGCAAGCTGGCCACGAACCAAATAATGAAGCTGGAAAACTGCGTCC
AGGCCAACAAGACCATCCAGAACCTCAGGTTCAACACTGAGGCCCGGCTGCGCACGCAGGAGATGGCCACCCTGTGGGAGAGTGTGCTCC
GGCTGTGGAGTGAGGAGGGCCCGCGGACGCCGCTGGGCAGCTGGAAGGCGCTCCCATCCCTGGTGAGGCCGCGGGTCTTCATCAAGGACA
TGGCGCCTGGCAAGGTGGTGCCCATGAACTGCTGGGGCGTGTACCAGGCTGTGAGGTGGCTGCGCTGGAAGGCGTCCCTCATAAAGCTCA
GGGCCCTGCGGAGGCCAGGAGGGGTCCTGGAGAAGCCCCACAGCCAGGAGCAGGTGCAGCAGCTCACACCCTCACTGTTTATCCAGAAAT

>45772_45772_5_LMF1-CCDC154_LMF1_chr16_960931_ENST00000568897_CCDC154_chr16_1489127_ENST00000389176_length(amino acids)=501AA_BP=52
MVRWESQLLETGFLGIFLCPLWTLSRLPQHTPTSRIVLWGFRWLIFRIMLGAAQVTKLGEEVSLRFLKREAKLCGFLQKSFLALEKRMKA
SESSRLKLEGSLRGELESRWEKLRGLMEERLRALQGQHEVGPGGRRAEESHLLEQCQGLDAAVAQLTKFVQQNQASLNRVLLAEEKAWDA
KGRLEESRAGELAAYVQENLEAAQLAGELARQEMHGELVLLREKSRALEASVAQLAGQLKELSGHLPALSSRLDLQEQMLGLRLSEAKTE
WEGAERKSLEDLARWRKEVTEHLRGVREKVDGLPQQIESVSDKCLLHKSDSDLRISAEGKAREFKVGALRQELATLLSSVQLLKEDNPGR
KIAEMQGKLATNQIMKLENCVQANKTIQNLRFNTEARLRTQEMATLWESVLRLWSEEGPRTPLGSWKALPSLVRPRVFIKDMAPGKVVPM

--------------------------------------------------------------
>45772_45772_6_LMF1-CCDC154_LMF1_chr16_960931_ENST00000568897_CCDC154_chr16_1489127_ENST00000409671_length(transcript)=1894nt_BP=542nt
GGCTCTCCGGCCCATCTCCACACGGGCACCTTCTGGCTGACCCGGATCGTGCTCCTGAAGGCCCTAGCCTTCGTGTACTTCGTGGCATTC
CTGGTGGCTTTCCATCAGAACAAGCAGCTCATCGGTGACAGGGGGCTGCTTCCCTGCAGAGTGTTCCTGAAGAACTTCCAGCAGTACTTC
CAGGACAGGACGAGCTGGGAAGTCTTCAGCTACATGCCCACCATCCTCTGGCTGATGGACTGGTCAGACATGAACTCCAACCTGGACTTG
CTGGCTCTTCTCGGACTGGGCATCTCGTCTTTCGTACTGATCACGGGCTGCGCCAACATGCTTCTCATGGCTGCCCTGTGGGGCCTCTAC
ATGTCCCTGGTTAATGTGGGCCATGTCTGGTGAGATGGGAGTCCCAGCTTCTGGAGACGGGGTTCCTGGGGATCTTCCTGTGCCCTCTGT
GGACGCTGTCAAGGCTGCCCCAGCATACCCCCACATCCCGGATTGTCCTGTGGGGCTTCCGGTGGCTGATCTTCAGGATCATGCTTGGAG
CAGCCCAGGTGACCAAGCTCGGCGAAGAGGTGAGCCTGCGCTTCCTGAAGAGGGAGGCCAAGCTGTGCGGCTTCCTGCAGAAGAGCTTCC
TGGCCCTGGAGAAGAGAATGAAGGCCTCGGAGAGCTCACGGCTGAAGCTGGAGGGCAGCCTGCGGGGCGAGCTGGAGAGCCGGTGGGAGA
AGCTTCGGGGGCTGATGGAGGAGCGCCTGCGGGCCCTGCAGGGGCAGCATGAGGAGAGCCACCTCCTGGAGCAGTGCCAGGGCCTGGATG
CTGCCGTGGCCCAGCTGACCAAGTTTGTGCAGCAGAACCAGGCGTCGCTGAACCGTGTCCTACTGGCCGAGGAGAAAGCCTGGGACGCCA
AGGGGCGCTTGGAGGAAAGCCGGGCTGGGGAGCTGGCCGCCTATGTGCAGGAGAACCTGGAGGCCGCACAGCTGGCTGGCGAGCTGGCCC
GGCAGGAGATGCATGGAGAGCTGGTGCTGCTCCGAGAGAAGAGCCGGGCTCTGGAGGCATCCGTGGCGCAGCTGGCCGGGCAGTTAAAGG
AGCTGAGTGGCCATCTCCCGGCTCTGAGCAGCCGGCTCGATCTGCAGGAGCAGATGCTGGGCCTCAGGCTGTCCGAGGCAAAGACCGAAT
GGGAAGGTGCAGAGAGGAAGTCCCTGGAGGACCTGGCCAGGTGGCGGAAGGAGGTGACCGAACACCTGCGAGGGGTGCGGGAGAAGGTGG
ATGGCCTCCCCCAGCAGATAGAGAGTGTCTCCGACAAGTGCCTGCTTCATAAGAGCGACTCAGACCTCAGGATTTCCGCCGAAGGCAAGG
CCAGGGAGTTCAAGGTTGGGGCCCTGCGGCAGGAGCTGGCCACGCTACTATCATCCGTGCAGCTGCTAAAGGAAGACAACCCTGGGCGGA
AGATCGCGGAGATGCAGGGCAAGCTGGCCACGTTTCAGAACCAAATAATGAAGCTGGAAAACTGCGTCCAGGCCAACAAGACCATCCAGA
ACCTCAGGTTCAACACTGAGGCCCGGCTGCGCACGCAGGAGATGGCCACCCTGTGGGAGAGTGTGCTCCGGCTGTGGAGTGAGGAGGGCC
CGCGGACGCCGCTGGGCAGCTGGAAGGCGCTCCCATCCCTGGTGAGGCCGCGGGTCTTCATCAAGGACATGGCGCCTGGCAAGGTGGTGC
CCATGAACTGCTGGGGCGTGTACCAGGCTGTGAGGTGGCTGCGCTGGAAGGCGTCCCTCATAAAGCTCAGGGCCCTGCGGAGGCCAGGAG
GGGTCCTGGAGAAGCCCCACAGCCAGGAGCAGGTGCAGCAGCTCACACCCTCACTGTTTATCCAGAAATAAACGTGCTGGCTTTGTACTC

>45772_45772_6_LMF1-CCDC154_LMF1_chr16_960931_ENST00000568897_CCDC154_chr16_1489127_ENST00000409671_length(amino acids)=494AA_BP=52
MVRWESQLLETGFLGIFLCPLWTLSRLPQHTPTSRIVLWGFRWLIFRIMLGAAQVTKLGEEVSLRFLKREAKLCGFLQKSFLALEKRMKA
SESSRLKLEGSLRGELESRWEKLRGLMEERLRALQGQHEESHLLEQCQGLDAAVAQLTKFVQQNQASLNRVLLAEEKAWDAKGRLEESRA
GELAAYVQENLEAAQLAGELARQEMHGELVLLREKSRALEASVAQLAGQLKELSGHLPALSSRLDLQEQMLGLRLSEAKTEWEGAERKSL
EDLARWRKEVTEHLRGVREKVDGLPQQIESVSDKCLLHKSDSDLRISAEGKAREFKVGALRQELATLLSSVQLLKEDNPGRKIAEMQGKL
ATFQNQIMKLENCVQANKTIQNLRFNTEARLRTQEMATLWESVLRLWSEEGPRTPLGSWKALPSLVRPRVFIKDMAPGKVVPMNCWGVYQ

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for LMF1-CCDC154

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for LMF1-CCDC154

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for LMF1-CCDC154

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source