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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:LMNA-MRAS (FusionGDB2 ID:45792)

Fusion Gene Summary for LMNA-MRAS

check button Fusion gene summary
Fusion gene informationFusion gene name: LMNA-MRAS
Fusion gene ID: 45792
HgeneTgene
Gene symbol

LMNA

MRAS

Gene ID

4000

22808

Gene namelamin A/Cmuscle RAS oncogene homolog
SynonymsCDCD1|CDDC|CMD1A|CMT2B1|EMD2|FPL|FPLD|FPLD2|HGPS|IDC|LDP1|LFP|LGMD1B|LMN1|LMNC|LMNL1|MADA|PRO1M-RAs|NS11|R-RAS3|RRAS3
Cytomap

1q22

3q22.3

Type of geneprotein-codingprotein-coding
Descriptionlamin70 kDa laminepididymis secretory sperm binding proteinlamin A/C-like 1mandibuloacral dysplasia type Aprelamin-A/Crenal carcinoma antigen NY-REN-32ras-related protein M-Rasmuscle and microspikes RASras-related protein R-Ras3
Modification date2020032920200313
UniProtAcc

P02545

O14807

Ensembl transtripts involved in fusion geneENST00000368301, ENST00000347559, 
ENST00000361308, ENST00000368297, 
ENST00000368299, ENST00000368300, 
ENST00000392353, ENST00000448611, 
ENST00000473598, ENST00000496738, 
ENST00000289104, ENST00000423968, 
ENST00000464896, ENST00000461114, 
ENST00000474559, 
Fusion gene scores* DoF score16 X 16 X 9=23044 X 4 X 3=48
# samples 214
** MAII scorelog2(21/2304*10)=-3.45567948377619
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: LMNA [Title/Abstract] AND MRAS [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointLMNA(156052975)-MRAS(138116164), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneLMNA

GO:0090343

positive regulation of cell aging

20458013


check buttonFusion gene breakpoints across LMNA (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across MRAS (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ADA808693LMNAchr1

156052975

+MRASchr3

138116164

+
ChiTaRS5.0N/ADA808737LMNAchr1

156052975

+MRASchr3

138116164

+


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Fusion Gene ORF analysis for LMNA-MRAS

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000368301ENST00000289104LMNAchr1

156052975

+MRASchr3

138116164

+
5UTR-3CDSENST00000368301ENST00000423968LMNAchr1

156052975

+MRASchr3

138116164

+
5UTR-5UTRENST00000368301ENST00000464896LMNAchr1

156052975

+MRASchr3

138116164

+
5UTR-intronENST00000368301ENST00000461114LMNAchr1

156052975

+MRASchr3

138116164

+
5UTR-intronENST00000368301ENST00000474559LMNAchr1

156052975

+MRASchr3

138116164

+
intron-3CDSENST00000347559ENST00000289104LMNAchr1

156052975

+MRASchr3

138116164

+
intron-3CDSENST00000347559ENST00000423968LMNAchr1

156052975

+MRASchr3

138116164

+
intron-3CDSENST00000361308ENST00000289104LMNAchr1

156052975

+MRASchr3

138116164

+
intron-3CDSENST00000361308ENST00000423968LMNAchr1

156052975

+MRASchr3

138116164

+
intron-3CDSENST00000368297ENST00000289104LMNAchr1

156052975

+MRASchr3

138116164

+
intron-3CDSENST00000368297ENST00000423968LMNAchr1

156052975

+MRASchr3

138116164

+
intron-3CDSENST00000368299ENST00000289104LMNAchr1

156052975

+MRASchr3

138116164

+
intron-3CDSENST00000368299ENST00000423968LMNAchr1

156052975

+MRASchr3

138116164

+
intron-3CDSENST00000368300ENST00000289104LMNAchr1

156052975

+MRASchr3

138116164

+
intron-3CDSENST00000368300ENST00000423968LMNAchr1

156052975

+MRASchr3

138116164

+
intron-3CDSENST00000392353ENST00000289104LMNAchr1

156052975

+MRASchr3

138116164

+
intron-3CDSENST00000392353ENST00000423968LMNAchr1

156052975

+MRASchr3

138116164

+
intron-3CDSENST00000448611ENST00000289104LMNAchr1

156052975

+MRASchr3

138116164

+
intron-3CDSENST00000448611ENST00000423968LMNAchr1

156052975

+MRASchr3

138116164

+
intron-3CDSENST00000473598ENST00000289104LMNAchr1

156052975

+MRASchr3

138116164

+
intron-3CDSENST00000473598ENST00000423968LMNAchr1

156052975

+MRASchr3

138116164

+
intron-3CDSENST00000496738ENST00000289104LMNAchr1

156052975

+MRASchr3

138116164

+
intron-3CDSENST00000496738ENST00000423968LMNAchr1

156052975

+MRASchr3

138116164

+
intron-5UTRENST00000347559ENST00000464896LMNAchr1

156052975

+MRASchr3

138116164

+
intron-5UTRENST00000361308ENST00000464896LMNAchr1

156052975

+MRASchr3

138116164

+
intron-5UTRENST00000368297ENST00000464896LMNAchr1

156052975

+MRASchr3

138116164

+
intron-5UTRENST00000368299ENST00000464896LMNAchr1

156052975

+MRASchr3

138116164

+
intron-5UTRENST00000368300ENST00000464896LMNAchr1

156052975

+MRASchr3

138116164

+
intron-5UTRENST00000392353ENST00000464896LMNAchr1

156052975

+MRASchr3

138116164

+
intron-5UTRENST00000448611ENST00000464896LMNAchr1

156052975

+MRASchr3

138116164

+
intron-5UTRENST00000473598ENST00000464896LMNAchr1

156052975

+MRASchr3

138116164

+
intron-5UTRENST00000496738ENST00000464896LMNAchr1

156052975

+MRASchr3

138116164

+
intron-intronENST00000347559ENST00000461114LMNAchr1

156052975

+MRASchr3

138116164

+
intron-intronENST00000347559ENST00000474559LMNAchr1

156052975

+MRASchr3

138116164

+
intron-intronENST00000361308ENST00000461114LMNAchr1

156052975

+MRASchr3

138116164

+
intron-intronENST00000361308ENST00000474559LMNAchr1

156052975

+MRASchr3

138116164

+
intron-intronENST00000368297ENST00000461114LMNAchr1

156052975

+MRASchr3

138116164

+
intron-intronENST00000368297ENST00000474559LMNAchr1

156052975

+MRASchr3

138116164

+
intron-intronENST00000368299ENST00000461114LMNAchr1

156052975

+MRASchr3

138116164

+
intron-intronENST00000368299ENST00000474559LMNAchr1

156052975

+MRASchr3

138116164

+
intron-intronENST00000368300ENST00000461114LMNAchr1

156052975

+MRASchr3

138116164

+
intron-intronENST00000368300ENST00000474559LMNAchr1

156052975

+MRASchr3

138116164

+
intron-intronENST00000392353ENST00000461114LMNAchr1

156052975

+MRASchr3

138116164

+
intron-intronENST00000392353ENST00000474559LMNAchr1

156052975

+MRASchr3

138116164

+
intron-intronENST00000448611ENST00000461114LMNAchr1

156052975

+MRASchr3

138116164

+
intron-intronENST00000448611ENST00000474559LMNAchr1

156052975

+MRASchr3

138116164

+
intron-intronENST00000473598ENST00000461114LMNAchr1

156052975

+MRASchr3

138116164

+
intron-intronENST00000473598ENST00000474559LMNAchr1

156052975

+MRASchr3

138116164

+
intron-intronENST00000496738ENST00000461114LMNAchr1

156052975

+MRASchr3

138116164

+
intron-intronENST00000496738ENST00000474559LMNAchr1

156052975

+MRASchr3

138116164

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for LMNA-MRAS


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
LMNAchr1156052975+MRASchr3138116165+9.65E-060.99999034
LMNAchr1156052975+MRASchr3138116165+9.65E-060.99999034

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for LMNA-MRAS


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:156052975/:138116164)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LMNA

P02545

MRAS

O14807

FUNCTION: Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. Lamin A and C are present in equal amounts in the lamina of mammals. Recruited by DNA repair proteins XRCC4 and IFFO1 to the DNA double-strand breaks (DSBs) to prevent chromosome translocation by immobilizing broken DNA ends (PubMed:31548606). Plays an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics. Required for normal development of peripheral nervous system and skeletal muscle and for muscle satellite cell proliferation (PubMed:10080180, PubMed:22431096, PubMed:10814726, PubMed:11799477, PubMed:18551513). Required for osteoblastogenesis and bone formation (PubMed:12075506, PubMed:15317753, PubMed:18611980). Also prevents fat infiltration of muscle and bone marrow, helping to maintain the volume and strength of skeletal muscle and bone (PubMed:10587585). Required for cardiac homeostasis (PubMed:10580070, PubMed:12927431, PubMed:18611980, PubMed:23666920). {ECO:0000269|PubMed:10080180, ECO:0000269|PubMed:10580070, ECO:0000269|PubMed:10587585, ECO:0000269|PubMed:10814726, ECO:0000269|PubMed:11799477, ECO:0000269|PubMed:12075506, ECO:0000269|PubMed:12927431, ECO:0000269|PubMed:15317753, ECO:0000269|PubMed:18551513, ECO:0000269|PubMed:18611980, ECO:0000269|PubMed:22431096, ECO:0000269|PubMed:23666920, ECO:0000269|PubMed:31548606}.; FUNCTION: Prelamin-A/C can accelerate smooth muscle cell senescence. It acts to disrupt mitosis and induce DNA damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature senescence.FUNCTION: Serves as an important signal transducer for a novel upstream stimuli in controlling cell proliferation. Activates the MAP kinase pathway. {ECO:0000269|PubMed:16630891, ECO:0000269|PubMed:28289718}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for LMNA-MRAS


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for LMNA-MRAS


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for LMNA-MRAS


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for LMNA-MRAS


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource